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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF19 Gene

protein-coding   GIFtS: 63
GCID: GC11M069513

Fibroblast Growth Factor 19

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibroblast Growth Factor 191 2
FGF-192 3

External Ids:    HGNC: 36751   Entrez Gene: 99652   Ensembl: ENSG000001623447   OMIM: 6038915   UniProtKB: O957503   

Export aliases for FGF19 gene to outside databases

Previous GC identifers: GC11M072007 GC11M071199 GC11M069760 GC11M069285 GC11M069222 GC11M065805


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF19 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes
including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth
factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal
but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required
for initiation of inner ear development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF19 Gene: 
FGF19 (fibroblast growth factor 19) is a protein-coding gene. Diseases associated with FGF19 include pseudosarcomatous fibromatosis, and functional diarrhea, and among its related super-pathways are Development FGF-family signaling and Rac1 Pathway. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF23.

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750
Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression,
following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity
requires the presence of KLB and FGFR4

Gene Wiki entry for FGF19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF19 gene promoter:
         Sp1   FOXF2   AP-1   ATF-2   c-Jun   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF19 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.1

FGF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069513:  view genomic region     (about GC identifiers)

Start:
69,513,000 bp from pter      End:
69,519,410 bp from pter
Size:
6,411 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750 (See protein sequence)
Recommended Name: Fibroblast growth factor 19 precursor  
Size: 216 amino acids; 24003 Da
Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts
with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the
presence of heparin, KL or KLB
Subcellular location: Secreted
Miscellaneous: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for
FGFR4
2 PDB 3D structures from and Proteopedia for FGF19:
1PWA (3D)        2P23 (3D)    

Explore the universe of human proteins at neXtProt for FGF19: NX_O95750

Explore proteomics data for FGF19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95750

  • FGF19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF19 Protein Expression
    REFSEQ proteins: NP_005108.1  
    ENSEMBL proteins: 
     ENSP00000294312  
    Reactome Protein details: O95750
    Human Recombinant Protein Products for FGF19: 
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    Enzo Life Sciences proteins for FGF19
    OriGene Purified Protein for FGF19
    OriGene Protein Over-expression Lysate for FGF19
    OriGene MassSpec for FGF19 
    OriGene Custom Protein Services for FGF19
    GenScript Purified and Recombinant Proteins for FGF19
    Novus Biologicals FGF19 Proteins
    Novus Biologicals FGF19 Lysates
    Sino Biological Recombinant Protein for FGF19
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FGF19
    Cloud-Clone Corp. Proteins for FGF19 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    FGF19 for ontologies           About GeneDecksing



    FGF19 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for FGF19 

    Assay Products for FGF19: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for FGF19 (FGF-19)         (see all)
    GenScript Custom Assay Services for FGF19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF19 
    Cloud-Clone Corp. CLIAs for FGF19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR017338 Fibroblast_GF_15/19/21
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry O95750

    ProtoNet protein and cluster: O95750

    1 Blocks protein domain: IPB002348 IL1/HBGF family signature

    UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750
    Similarity: Belongs to the heparin-binding growth factors family


    FGF19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF19_HUMAN, O95750
    Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression,
    following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity
    requires the presence of KLB and FGFR4
    Induction: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within
    intron 2

         Genatlas biochemistry entry for FGF19:
    fibroblast growth factor 19,heparin dependent ligand for FGFR4,expressed in fetal brain,skin,cartilage and
    retina,gall bladder,potentially playing an important role in brain development,overexpressed in colon
    adenocarcinoma cell line

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI10525310
    GO:0005515protein binding IPI18829467
    GO:0008083growth factor activity IEA--
         
    FGF19 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FGF19:
     Decreased influenza A/WSN/33 r  Increased circadian period len 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgf15):
     cardiovascular system  cellular  embryogenesis  hearing/vestibular/ear  mortality/aging 

    FGF19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FGF19: Fgf15tm1Lex Fgf15tm1Sms

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGF19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF19 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF19 

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    SwitchGear 3'UTR luciferase reporter plasmidFGF19 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for FGF19
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF19
    Sirion Biotech Customized lentivirus for stable overexpression of FGF19 
                         Customized lentivirus expression plasmids for stable overexpression of FGF19 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF19 About   (see all 33)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development FGF-family signaling
    Development FGF-family signaling0.63
    FGF Pathway0.38
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72
    5IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FGF19
        Development FGF-family signaling

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF19 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF19
        Development FGF-family signaling

    2 BioSystems Pathways for FGF19
        Neural Crest Differentiation
    FGF signaling pathway


    5/47        Reactome Pathways for FGF19 (see all 47)
        Klotho-mediated ligand binding
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Downstream signal transduction
    IRS-mediated signalling


    5/6         Kegg Pathways  (Kegg details for FGF19) (see all 6):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Proteoglycans in cancer


    FGF19 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/21 Interacting proteins for FGF19 (O957503 ENSP000002943124) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=2 STRING: ENSP00000292408
    KHDRBS3O755253I2D: score=1 
    PLSCR1O151623I2D: score=1 
    TRAF2Q129333I2D: score=1 
    FGF1ENSP000003385484STRING: ENSP00000338548
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007399nervous system development TAS9931477
    GO:0007507heart development IEA--
    GO:0008284positive regulation of cell proliferation IGI18187602

    FGF19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF19 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF19

    4 Novoseek inferred chemical compound relationships for FGF19 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chenodeoxycholic acid 69.5 4 19085950 (1), 17116003 (1), 17823458 (1)
    heparin 41.6 1 10525310 (1)
    cholesterol 29.7 2 19085950 (2)
    lipid 13.5 2 18609104 (1), 17116003 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF19 gene: 
    NM_005117.2  

    Unigene Cluster for FGF19:

    Fibroblast growth factor 19
    Hs.249200  [show with all ESTs]
    Unigene Representative Sequence: NM_005117
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000294312(uc001opf.3)
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF19:
    hsa-miR-9* hsa-miR-493* hsa-miR-3945 hsa-miR-513c hsa-miR-514b-5p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidFGF19 3' UTR sequence
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    Additional mRNA sequence: 

    AB018122.1 AF110400.1 AY358302.1 BC017664.1 BT006729.1 

    1 DOTS entry:

    DT.405022 

    24/25 AceView cDNA sequences (see all 25):

    NM_005117 CR610453 BE889616 AB018122 AY358302 AF110400 BC017664 BT006729 
    AA218987 AA232080 AA220994 AL530420 AI076490 BE869144 BI919047 AI654914 
    BG328684 AI265931 AL563740 BX390234 BX350012 AA232079 AI921200 AI921179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF19 expression in normal human tissues (normalized intensities)      FGF19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTTATGA
    FGF19 Expression
    About this image


    FGF19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 11 entries
             Anterior Neural Ridge Cells Neural Plate
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
             Retina
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See FGF19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF19

    SOURCE GeneReport for Unigene cluster: Hs.249200

    UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750
    Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder

        SABiosciences Expression via Pathway-Focused PCR Array including FGF19: 
              Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF19 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf151 , 5 fibroblast growth factor 151, 5 67.31(n)1
    54.11(a)1
      7 (88.92 cM)5
    141701  NM_008003.21  NP_032029.11 
     1448965325 
    chicken
    (Gallus gallus)
    Aves FGF191 fibroblast growth factor 19 69.7(n)
    64.14(a)
      395394  NM_204674.1  NP_990005.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF196
    Uncharacterized protein
    60(a)
    1 ↔ 1
    1(55245621-55255597)
    zebrafish
    (Danio rerio)
    Actinopterygii fgf191 fibroblast growth factor 19 54.41(n)
    45.95(a)
      368245  NM_001012246.1  NP_001012246.1 


    ENSEMBL Gene Tree for FGF19 (if available)
    TreeFam Gene Tree for FGF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF19 gene
    FGF232  FGF212  
    1 SIMAP similar gene for FGF19 using alignment to 1 protein entry:     FGF19_HUMAN:
    FGF21

    FGF19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/138 SNPs in FGF19 are shown (see all 138)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160259471,2
    C,F--69512592(+) TTTCTA/GCAGGC 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1407236231,2
    --69512597(+) ACAGGC/TATCTA 1 -- ds50010--------
    rs1122462391,2
    C,F--69512609(+) TGGTGG/CGGGGT 1 -- ds50012Minor allele frequency- C:0.08CSA WA 120
    rs1479118011,2
    C--69512614(+) GGGGT-/GGGGGG 1 -- ds50010--------
    rs1127534441,2
    F--69512618(+) GTGGGG/AGGGGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1504744921,2
    --69512670(+) GAGGGC/TGAGAG 1 -- ds50010--------
    rs11929291,2
    C,A--69512674(-) GGGCCT/CCTCGC 1 -- ds50016Minor allele frequency- C:0.37NA WA EA 364
    rs1897603891,2
    --69512677(+) AGAGGC/TCCTCA 1 -- ds50010--------
    rs779549251,2
    C,F--69512739(+) GCAGAG/CAGGCC 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs791763301,2
    C,F--69512745(+) AGGCCG/ACCCTA 1 -- ds50011Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for FGF19 (69513000 - 69519410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGF19:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv16n68CNV Loss17160897
    nsv825973CNV Gain20364138
    nsv825974CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603891    OMIM disorders: --

    20/27 diseases for FGF19 (see all 27):    About MalaCards
    pseudosarcomatous fibromatosis    functional diarrhea    extrahepatic cholestasis    leptin deficiency
    reticulosarcoma    diarrhea    constipation    fibromatosis
    fatty liver disease    cushing's syndrome    cholestasis    anorexia nervosa
    colon adenocarcinoma    liver disease    insulin resistance    atherosclerosis
    obesity    colon cancer    hepatocellular carcinoma    adenocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for FGF19:
    Lymphoma     Reticulosarcoma

    FGF19 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FGF19 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diarrhea chronic 50 1 19665580 (1)

    Genetic Association Database (GAD): FGF19

    Export disorders for FGF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF19 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with FGF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. (PubMed id 10525310)1, 2, 3, 9 Xie M.-H....Gurney A.L. (1999)
    2. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. (PubMed id 9931477)1, 2, 3 Nishimura T.... Itoh N. (1999)
    3. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (PubMed id 12815072)1, 2, 9 Holt J.A....Jones S.A. (2003)
    4. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. (PubMed id 17339340)1, 2, 9 Goetz R.... Mohammadi M. (2007)
    5. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. (PubMed id 14730967)1, 2, 9 Harmer N.J....Blundell T.L. (2004)
    6. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PubMed id 17623664)1, 2, 9 Kurosu H....Kuro-o M. (2007)
    7. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. (PubMed id 18829467)1, 2 Wu X....Li Y. (2008)
    8. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (2006)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9965 HGNC: 3675 AceView: FGF19 Ensembl:ENSG00000162344 euGenes: HUgn9965
    ECgene: FGF19 Kegg: 9965 H-InvDB: FGF19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF19 gene:
    Search GeneIP for patents involving FGF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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