Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FGF19 Gene

protein-coding   GIFtS: 62
GCID: GC11M069513

Fibroblast Growth Factor 19

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fibroblast Growth Factor 191 2
FGF-192 3

External Ids:    HGNC: 36751   Entrez Gene: 99652   Ensembl: ENSG000001623447   OMIM: 6038915   UniProtKB: O957503   

Export aliases for FGF19 gene to outside databases

Previous GC identifers: GC11M072007 GC11M071199 GC11M069760 GC11M069285 GC11M069222 GC11M065805


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FGF19 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes
including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth
factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal
but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required
for initiation of inner ear development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF19 Gene:
FGF19 (fibroblast growth factor 19) is a protein-coding gene. Diseases associated with FGF19 include pseudosarcomatous fibromatosis, and functional diarrhea. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF23.

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750
Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression,
following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity
requires the presence of KLB and FGFR4

Gene Wiki entry for FGF19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF19 gene promoter:
         Sp1   FOXF2   AP-1   ATF-2   c-Jun   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF19 promoter sequence
   Search Chromatin IP Primers for FGF19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.1

FGF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069513:  view genomic region     (about GC identifiers)

Start:
69,513,000 bp from pter      End:
69,519,410 bp from pter
Size:
6,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750 (See protein sequence)
Recommended Name: Fibroblast growth factor 19 precursor  
Size: 216 amino acids; 24003 Da
Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts
with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the
presence of heparin, KL or KLB
Miscellaneous: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for
FGFR4
2 PDB 3D structures from and Proteopedia for FGF19:
1PWA (3D)        2P23 (3D)    

Explore the universe of human proteins at neXtProt for FGF19: NX_O95750

Explore proteomics data for FGF19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005108.1  
    ENSEMBL proteins: 
     ENSP00000294312  
    Reactome Protein details: O95750

    FGF19 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FGF19 (FGF-19)
    Enzo Life Sciences proteins for FGF19
    OriGene Purified Protein for FGF19
    OriGene Protein Over-expression Lysate for FGF19
    OriGene MassSpec for FGF19
    OriGene Custom Protein Services for FGF19
    GenScript Purified and Recombinant Proteins for FGF19
    Novus Biologicals FGF19 Proteins
    Novus Biologicals FGF19 Lysates
    Sino Biological Recombinant Protein for FGF19
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FGF19
    Cloud-Clone Corp. Proteins for FGF19

    FGF19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF19 (FGF-19)
    OriGene Antibodies for FGF19
    OriGene Custom Antibody Services for FGF19
    Novus Biologicals FGF19 Antibodies
    Abcam antibodies for FGF19
    Cloud-Clone Corp. Antibodies for FGF19
    Search ThermoFisher Antibodies for FGF19
    LSBio Antibodies in human, mouse, rat for FGF19

    FGF19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FGF19
    R&D Systems ELISAs for FGF19 (FGF-19)         (see all)
    GenScript Custom Assay Services for FGF19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF19
    Cloud-Clone Corp. CLIAs for FGF19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028302 FGF19

    Graphical View of Domain Structure for InterPro Entry O95750

    ProtoNet protein and cluster: O95750

    1 Blocks protein domain: IPB002348 IL1/HBGF family signature

    UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750
    Similarity: Belongs to the heparin-binding growth factors family


    FGF19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF19_HUMAN, O95750
    Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression,
    following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity
    requires the presence of KLB and FGFR4
    Induction: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within
    intron 2

         Genatlas biochemistry entry for FGF19:
    fibroblast growth factor 19,heparin dependent ligand for FGFR4,expressed in fetal brain,skin,cartilage and
    retina,gall bladder,potentially playing an important role in brain development,overexpressed in colon
    adenocarcinoma cell line

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI10525310
    GO:0005515protein binding IPI18829467
    GO:0008083growth factor activity IEA--
         
    FGF19 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FGF19:
     Decreased influenza A/WSN/33 r  Increased circadian period len 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgf15):
     cardiovascular system  cellular  embryogenesis  hearing/vestibular/ear  mortality/aging 

    FGF19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FGF19: Fgf15tm1Lex Fgf15tm1Sms

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF19
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF19
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF19

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FGF19 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FGF19:
    hsa-miR-9* hsa-miR-493* hsa-miR-3945 hsa-miR-513c hsa-miR-514b-5p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidFGF19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF19
    Predesigned siRNA for gene silencing in human, mouse, rat FGF19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF19

    Clone
    Products:
         
    OriGene clones in human, mouse for FGF19 (see all 7)
    OriGene ORF clones in mouse, rat for FGF19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF19 (NM_005117)
    Sino Biological Human cDNA Clone for FGF19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF19

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FGF19
    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF19 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FGF19_HUMAN, O95750: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    FGF19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FGF19 About   (see all 32)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    Development FGF family signaling0.43
    SHC-mediated cascade0.79
    FGFR4 ligand binding and activation0.00
    FRS2-mediated cascade0.70
    Klotho-mediated ligand binding0.00
    Negative regulation of FGFR signaling0.56
    betaKlotho-mediated ligand binding0.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    IRS-related events triggered by IGF1R0.92
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PI3K Cascade0.87
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF19 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF19
        Development FGF-family signaling

    2 BioSystems Pathways for FGF19
        Neural Crest Differentiation
    FGF signaling pathway


    Selected Reactome Pathways for FGF19 (see all 10)
        PI3K Cascade
    betaKlotho-mediated ligand binding
    Phospholipase C-mediated cascade
    FRS2-mediated cascade
    FGFR4 ligand binding and activation


    Selected Kegg Pathways  (Kegg details for FGF19) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton


    FGF19 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF19: 
              Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for FGF19 (O957503 ENSP000002943124) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=2 STRING: ENSP00000292408
    KHDRBS3O755253I2D: score=1 
    PLSCR1O151623I2D: score=1 
    TRAF2Q129333I2D: score=1 
    FGF1ENSP000003385484STRING: ENSP00000338548
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007399nervous system development TAS9931477
    GO:0007507heart development IEA--
    GO:0008284positive regulation of cell proliferation IGI18187602

    FGF19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF19

    4 Novoseek inferred chemical compound relationships for FGF19 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chenodeoxycholic acid 69.5 4 19085950 (1), 17116003 (1), 17823458 (1)
    heparin 41.6 1 10525310 (1)
    cholesterol 29.7 2 19085950 (2)
    lipid 13.5 2 18609104 (1), 17116003 (1)



    FGF19 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FGF19 gene: 
    NM_005117.2  

    Unigene Cluster for FGF19:

    Fibroblast growth factor 19
    Hs.249200  [show with all ESTs]
    Unigene Representative Sequence: NM_005117
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000294312(uc001opf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FGF19 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FGF19:
    hsa-miR-9* hsa-miR-493* hsa-miR-3945 hsa-miR-513c hsa-miR-514b-5p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidFGF19 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FGF19
    Predesigned siRNA for gene silencing in human, mouse, rat FGF19
    Clone
    Products:
         
    OriGene clones in human, mouse for FGF19 (see all 7)
    OriGene ORF clones in mouse, rat for FGF19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF19 (NM_005117)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF19
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF19
      QuantiTect SYBR Green Assays in human, mouse, rat FGF19
      QuantiFast Probe-based Assays in human, mouse, rat FGF19

    Additional mRNA sequence: 

    AB018122.1 AF110400.1 AY358302.1 BC017664.1 BT006729.1 

    1 DOTS entry:

    DT.405022 

    Selected AceView cDNA sequences (see all 25):

    AF110400 AB018122 BC017664 NM_005117 AY358302 BE889616 CR610453 AA232080 
    AI076490 BG328684 BE869144 AL530420 BI919047 AA220994 AI654914 BT006729 
    AA218987 AI265931 BX390234 AL563740 BX350012 AA232079 AI921179 AI921200 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FGF19 expression in normal human tissues (normalized intensities)      FGF19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTTATGA
    FGF19 Expression
    About this image


    FGF19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 12 entries
             Anterior Neural Ridge Cells Neural Plate
             Mesencephalic Ventricular Zone
             Floor plate-like cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
             Outer Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Neural Ectoderm (Nervous System)
             Anterior Neural Ridge Cells Neural Plate
    FGF19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249200

    UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750
    Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF19: 
              Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF19
    QuantiTect SYBR Green Assays in human, mouse, rat FGF19
    QuantiFast Probe-based Assays in human, mouse, rat FGF19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF19 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf151 , 5 fibroblast growth factor 151, 5 67.31(n)1
    54.11(a)1
      7 (88.92 cM)5
    141701  NM_008003.21  NP_032029.11 
     1448965325 
    chicken
    (Gallus gallus)
    Aves FGF191 fibroblast growth factor 19 69.7(n)
    64.14(a)
      395394  NM_204674.1  NP_990005.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF196
    fibroblast growth factor 19
    59(a)
    1 ↔ 1
    1(55245621-55255597)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgf191 fibroblast growth factor 19 60.88(n)
    54.74(a)
      100217329  NM_001142825.1  NP_001136297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf191 fibroblast growth factor 19 53.61(n)
    45.36(a)
      368245  NM_001012246.1  NP_001012246.1 


    ENSEMBL Gene Tree for FGF19 (if available)
    TreeFam Gene Tree for FGF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FGF19 gene
    FGF232  FGF212  
    1 SIMAP similar gene for FGF19 using alignment to 1 protein entry:     FGF19_HUMAN:
    FGF21

    FGF19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FGF19 (see all 138)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160259471,2
    C,F--69512592(+) TTTCTA/GCAGGC 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1407236231,2
    --69512597(+) ACAGGC/TATCTA 1 -- ds50010--------
    rs1122462391,2
    C,F--69512609(+) TGGTGG/CGGGGT 1 -- ds50012Minor allele frequency- C:0.08CSA WA 120
    rs1479118011,2
    C--69512614(+) GGGGT-/GGGGGG 1 -- ds50010--------
    rs1127534441,2
    F--69512618(+) GTGGGG/AGGGGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1504744921,2
    --69512670(+) GAGGGC/TGAGAG 1 -- ds50010--------
    rs11929291,2
    C,A--69512674(-) GGGCCT/CCTCGC 1 -- ds50016Minor allele frequency- C:0.37NA WA EA 364
    rs1897603891,2
    --69512677(+) AGAGGC/TCCTCA 1 -- ds50010--------
    rs779549251,2
    C,F--69512739(+) GCAGAG/CAGGCC 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs791763301,2
    C,F--69512745(+) AGGCCG/ACCCTA 1 -- ds50011Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for FGF19 (69513000 - 69519410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGF19:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv16n68CNV Loss17160897
    nsv825973CNV Gain20364138
    nsv825974CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF19
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603891    OMIM disorders: --

    Selected diseases for FGF19 (see all 29):    About MalaCards
    pseudosarcomatous fibromatosis    functional diarrhea    extrahepatic cholestasis    leptin deficiency
    reticulosarcoma    diarrhea    constipation    fatty liver disease
    fibromatosis    cushing's syndrome    anorexia nervosa    cholestasis
    irritable bowel syndrome    liver disease    colon adenocarcinoma    insulin resistance
    obesity    endotheliitis    atherosclerosis    diabetes mellitus

    2 diseases from the University of Copenhagen DISEASES database for FGF19:
    Lymphoma     Reticulosarcoma

    FGF19 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FGF19 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diarrhea chronic 50 1 19665580 (1)

    Genetic Association Database (GAD): FGF19

    Export disorders for FGF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FGF19 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with FGF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. (PubMed id 10525310)1, 2, 3, 9 Xie M.-H....Gurney A.L. (Cytokine 1999)
    2. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. (PubMed id 9931477)1, 2, 3 Nishimura T.... Itoh N. (Biochim. Biophys. Acta 1999)
    3. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (PubMed id 12815072)1, 2, 9 Holt J.A....Jones S.A. (Genes Dev. 2003)
    4. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. (PubMed id 17339340)1, 2, 9 Goetz R.... Mohammadi M. (Mol. Cell. Biol. 2007)
    5. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. (PubMed id 14730967)1, 2, 9 Harmer N.J....Blundell T.L. (Biochemistry 2004)
    6. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PubMed id 17623664)1, 2, 9 Kurosu H....Kuro-o M. (J. Biol. Chem. 2007)
    7. C-terminal tail of FGF19 determines its specificity toward Klotho co- receptors. (PubMed id 18829467)1, 2 Wu X.... Li Y. (J. Biol. Chem. 2008)
    8. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (J. Biol. Chem. 2006)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9965 HGNC: 3675 AceView: FGF19 Ensembl:ENSG00000162344 euGenes: HUgn9965
    ECgene: FGF19 Kegg: 9965 H-InvDB: FGF19

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FGF19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FGF19 gene:
    Search GeneIP for patents involving FGF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FGF19 (FGF-19)   Browse Cell Culture Products  
     ELISAs for FGF19 (FGF-19)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FGF19 (FGF-19)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for FGF19 (FGF-19)  
     OriGene Antibodies for FGF19   OriGene RNAi products in human, mouse, rat for FGF19  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FGF19  
     OriGene MassSpec something-or-other for FGF19   OriGene clones in human, mouse for FGF19  
     OriGene qSTAR qPCR primer pairs in human, mouse for FGF19   OriGene Purified Protein for FGF19  
     OriGene ORF clones in mouse, rat for FGF19   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FGF19   OriGene Custom Protein Services for FGF19  

     
     
     Block miRNA regulation of human, mouse, rat FGF19 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FGF19
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF19 Predesigned siRNA for gene silencing in human, mouse, rat FGF19
     QuantiFast Probe-based Assays in human, mouse, rat FGF19 QuantiTect SYBR Green Assays in human, mouse, rat FGF19
     PCR Arrays including human, mouse, rat FGF19 Search Chromatin IP Primers for FGF19
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF19  GeneGlobe Interaction Network for FGF19
     Regulatory tfbs in FGF19 promoter
     GenScript Purified and Recombinant Proteins for FGF19 GenScript cDNA clones with any tag delivered in your preferred vector for FGF19
     GenScript Custom Assay Services for FGF19 GenScript Custom overexpressing Cell Line Services for FGF19
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FGF19
     Proteins for FGF19
     Browse Sino Biological Cell Lysates
     cDNA Clones for FGF19
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for FGF19
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FGF19 antibodies
     FGF19 proteins
     FGF19 lysates
     Antibodies for FGF19
     See all of Abcam's Antibodies, Kits and Proteins for FGF19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FGF19
     Proteins for FGF19
     Antibodies for FGF19
     ELISAs for FGF19
     CLIAs for FGF19



     Browse ESI BIO Cell Lines and PureStem Progenitors for FGF19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19
     SwitchGear 3'UTR luciferase reporter plasmids for FGF19
     SwitchGear Promoter luciferase reporter plasmids for FGF19
     Search ThermoFisher Antibodies for FGF19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF19
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF19
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF19
     LSBio Antibodies in human, mouse, rat for FGF19
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FGF19 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4