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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF19 Gene

protein-coding GIFtS: 63
GCID: GC11M069513

fibroblast growth factor 19

Explore 30 diseases affiliated with
FGF19 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 19¹ ²
FGF-19² ³

External Ids:	HGNC: 3675¹	Entrez Gene: 9965²	Ensembl: ENSG00000162344⁷	OMIM: 603891⁵	UniProtKB: O95750³

Export aliases for FGF19 gene to outside databases

Previous GC identifers: GC11M072007 GC11M071199 GC11M069760 GC11M069285 GC11M069222 GC11M065805

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF19:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes including

embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a

high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult

brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of

inner ear development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750

Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following

positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the

presence of KLB and FGFR4

Gene Wiki entry for FGF19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF19 gene promoter:
Sp1 FOXF2 AP-1 ATF-2 c-Jun Tal-1beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF19 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF19

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.3 HGNC cytogenetic band: 11q13.1

FGF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF19 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M069513: view genomic region (about GC identifiers)

Start:	69,513,000 bp from pter	End:	69,519,410 bp from pter
Size:	6,411 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750 (See protein sequence)

Recommended Name: Fibroblast growth factor 19 precursor

Size: 216 amino acids; 24003 Da

Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their

receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with

KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence

of heparin, KL or KLB

Subcellular location: Secreted

Miscellaneous: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for

FGFR4

2 PDB 3D structures from and Proteopedia for FGF19:

1PWA (3D)

2P23 (3D)

Explore the universe of human proteins at neXtProt for FGF19: NX_O95750

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95750

FGF19 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005108.1

ENSEMBL proteins:

ENSP00000294312

Reactome Protein details: O95750
Human Recombinant Protein Products:

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	Uscn Proteins for FGF19

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

FGF19 for ontologies About GeneDecksing

FGF19 Antibody Products:

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Assay Products for FGF19:

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	Uscn ELISAs and CLIAs for FGF19

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF19 for domains About GeneDecksing

4 InterPro domains/families:

IPR002348 IL1_HBGF

IPR017338 Fibroblast_GF_15/19/21

IPR008996 Cytokine_IL1-like

IPR002209 GF_heparin-bd

Graphical View of Domain Structure for InterPro Entry O95750

ProtoNet protein and cluster: O95750

1 Blocks protein family: IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750

Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following

positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the

presence of KLB and FGFR4

Induction: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2

Genatlas biochemistry entry for FGF19:

fibroblast growth factor 19,heparin dependent ligand for FGFR4,expressed in fetal brain,skin,cartilage and retina,gall

bladder,potentially playing an important role in brain development,overexpressed in colon adenocarcinoma cell line

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF19
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF19:
		hsa-miR-9* hsa-miR-493* hsa-miR-3945 hsa-miR-513c hsa-miR-514b-5p hsa-miR-512-3p
		SwitchGear 3'UTR luciferase reporter plasmid: FGF19 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for FGF19

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005104	fibroblast growth factor receptor binding	IPI	10525310
GO:0005515	protein binding	IPI	18829467
GO:0008083	growth factor activity	IEA	--

FGF19 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FGF19:

Decreased influenza A/WSN/33 r

Increased circadian period len

Animal Models:
Mouse knock-outs for FGF19: Fgf15^tm1Lex Fgf15^tm1Sms
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fgf15):

cardiovascular system

cellular

embryogenesis

hearing/vestibular/ear

mortality/aging

FGF19 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FGF19

Development FGF-family signaling

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF19 (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for FGF19

Development FGF-family signaling

2 BioSystems Pathways for FGF19

	Neural Crest Differentiation
	FGF signaling pathway

5/45 Reactome Pathways for FGF19 (see all 45)

	Klotho-mediated ligand binding
	FGFR ligand binding and activation
	Signaling by EGFR in Cancer
	Downstream signal transduction
	IRS-mediated signalling

4 Kegg Pathways (Kegg details for FGF19):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF19 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FGF19

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/21 Interacting proteins for FGF19 (O95750³ ENSP00000294312⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR4	P22455³, ENSP00000292408⁴	I2D: score=2 STRING: ENSP00000292408
KHDRBS3	O75525³	I2D: score=1
PLSCR1	O15162³	I2D: score=1
TRAF2	Q12933³	I2D: score=1
FGF1	ENSP00000338548⁴	STRING: ENSP00000338548

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001755	neural crest cell migration	IEA	--
GO:0007399	nervous system development	TAS	9931477
GO:0007507	heart development	IEA	--
GO:0008284	positive regulation of cell proliferation	IGI	18187602
GO:0008286	insulin receptor signaling pathway	TAS	--

FGF19 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FGF19 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF19
4 Novoseek chemical compound relationships for FGF19 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chenodeoxycholic acid	69.5	4	19085950 (1), 17116003 (1), 17823458 (1)
heparin	41.6	1	10525310 (1)
cholesterol	29.7	2	19085950 (2)
lipid	13.5	2	18609104 (1), 17116003 (1)

Search CenterWatch for drugs/clinical trials and news about FGF19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF19 gene:

NM_005117.2

Unigene Cluster for FGF19:

Fibroblast growth factor 19

Hs.249200 [show with all ESTs]

Unigene Representative Sequence: NM_005117

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000294312(uc001opf.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF19
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF19:
		hsa-miR-9* hsa-miR-493* hsa-miR-3945 hsa-miR-513c hsa-miR-514b-5p hsa-miR-512-3p
		SwitchGear 3'UTR luciferase reporter plasmid: FGF19 3' UTR sequence

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Additional cDNA sequence:

AB018122.1 AF110400.1 AY358302.1 BC017664.1 BT006729.1

1 DOTS entry:

DT.405022

24/25 AceView cDNA sequences (see all 25):

BE889616 NM_005117 AF110400 CR610453 AY358302 BC017664 AB018122 AA220994

BI919047 BT006729 BG328684 AA232080 AI076490 BE869144 AI654914 AL530420

AA218987 AI265931 AL563740 BX390234 BX350012 AA232079 AI921179 AI921200

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATTTATGA

About this image

FGF19 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retinal Pigmented Epithelium

Retinal Pigmented Epithelium Progenitor Cells

Retinal Pigmented Epithelium

Eye

Neuroblastic Layer

Early Retinal Progenitor Cells

Retina

Neural Ectoderm

Neural Plate

Anterior Neural Ridge Cells

Neural Ectoderm

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FGF19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF19

SOURCE GeneReport for Unigene cluster: Hs.249200

UniProtKB/Swiss-Prot: FGF19_HUMAN, O95750

Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder

SABiosciences Expression via Pathway-Focused PCR Array including FGF19:

Growth Factors in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FGF19 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGF19¹	fibroblast growth factor 19	69.7(n) 64.14(a)		395394 NM_204674.1 NP_990005.1
lizard (Anolis carolinensis)	Reptilia	FGF19⁶	--	57(a)	1 ↔ 1	1(55245550-55253917)
zebrafish (Danio rerio)	Actinopterygii	fgf19¹	fibroblast growth factor 19	54.41(n) 45.95(a)		368245 NM_001012246.1 NP_001012246.1

ENSEMBL Gene Tree for FGF19 (if available)
TreeFam Gene Tree for FGF19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF19 gene

FGF23² FGF21²

1 SIMAP similar gene for FGF19 using alignment to 1 protein entry: FGF19_HUMAN:

FGF21

FGF19 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116025947^1,2	F,	--	69512592(+)	`TTTCTA/GCAGGC`	1	--	ds500¹		1		WA	118
rs140723623^1,2		--	69512597(+)	`ACAGGC/TATCTA`	1	--	ds500¹		0	--	--	--	--
rs147911801^1,2	C,	--	69512608(+)	`GGGGT-/GGGGGG`	1	--	ds500¹		0	--	--	--	--
rs112246239^1,2		--	69512609(+)	`TGGTGG/CGGGGT`	1	--	ds500¹		2		CSA WA	120
rs112753444^1,2		--	69512618(+)	`GTGGGG/AGGGGC`	1	--	ds500¹		1		CSA	2
rs150474492^1,2		--	69512670(+)	`GAGGGC/TGAGAG`	1	--	ds500¹		0	--	--	--	--
rs1192929^1,2	C,A,	--	69512674(-)	`GGGCCT/CCTCGC`	1	--	ds500¹		6		NA WA EA	364
rs189760389^1,2		--	69512677(+)	`AGAGGC/TCCTCA`	1	--	ds500¹		0	--	--	--	--
rs77954925^1,2	C,F,	--	69512739(+)	`GCAGAG/CAGGCC`	1	--	ds500¹		1		WA	118
rs79176330^1,2	F,	--	69512745(+)	`AGGCCG/ACCCTA`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for FGF19 (69513000 - 69519410 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FGF19
1 CNV: 4755

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF19

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FGF19 for disorders           About GeneDecksing

OMIM gene information: 603891    OMIM disorders: --

20/30 diseases for FGF19 (see all 30):    About MalaCards

bile acid malabsorption pseudosarcomatous fibromatosis extrahepatic cholestasis leptin deficiency

functional diarrhea anorexia nervosa fatty liver disease reticulosarcoma

diarrhea cholestasis insulin resistance cushing's syndrome

fibromatosis liver disease constipation embryonal carcinoma

colon adenocarcinoma liver cancer hepatocellular carcinoma colon cancer

2 diseases from the University of Copenhagen DISEASES database for FGF19:

Lymphoma Reticulosarcoma

1 Novoseek disease relationship for FGF19 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
diarrhea chronic	50	1	19665580 (1)

Export disorders for FGF19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FGF19 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with FGF19)

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FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. (PubMed id 10525310)^{1, 2, 3, 9} Xie M.-H....Gurney A.L. (1999)
Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. (PubMed id 9931477)^{1, 2, 3} Nishimura T.... Itoh N. (1999)
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (PubMed id 12815072)^{1, 2, 9} Holt J.A....Jones S.A. (2003)
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. (PubMed id 17339340)^{1, 2, 9} Goetz R.... Mohammadi M. (2007)
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. (PubMed id 14730967)^{1, 2, 9} Harmer N.J....Blundell T.L. (2004)
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PubMed id 17623664)^{1, 2, 9} Kurosu H....Kuro-o M. (2007)
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. (PubMed id 18829467)^{1, 2} Wu X....Li Y. (2008)
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)^{1, 2} Zhang X....Ornitz D.M. (2006)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9965	HGNC: 3675	AceView: FGF19	Ensembl:ENSG00000162344	euGenes: HUgn9965
ECgene: FGF19	Kegg: 9965	H-InvDB: FGF19

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FGF19	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF19	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FGF19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FGF19 gene:
Search GeneIP for patents involving FGF19

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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fibroblast growth factor 19

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fibroblast growth factor 19

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