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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF18 Gene

protein-coding   GIFtS: 61
GCID: GC05P170846

fibroblast growth factor 18
 Explore 17 diseases affiliated with
FGF18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGF18    

Aliases
for FGF18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fibroblast Growth Factor 181 2
FGF-181 2 3
ZFGF51 2
ZFGF51 2

External Ids:    HGNC: 36741   Entrez Gene: 88172   Ensembl: ENSG000001564277   OMIM: 6037265   UniProtKB: O760933   
ORGUL members:         
NONCODE:n340740    

Export aliases for FGF18 gene to outside databases

Previous GC identifers: GC05P171049 GC05P171549 GC05P170782 GC05P170827 GC05P170779 GC05P165944


Summaries
for FGF18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF18:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including
embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in
vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse
and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of
tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of
this protein in regulating proliferation and differentiation of midline cerebellar structures. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: FGF18_HUMAN, O76093
Function: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration.
Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation

Gene Wiki entry for FGF18


Genomic Views
for FGF18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF18 gene promoter:
         COUP-TF1   STAT1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF18 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q34

FGF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF18 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170846:  view genomic region     (about GC identifiers)

Start:
 170,846,660 bp from pter      End:
 170,884,630 bp from pter
Size:
 37,971 bases      Orientation:
 plus strand

Proteins
for FGF18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF18_HUMAN, O76093 (See protein sequence)
Recommended Name: Fibroblast growth factor 18 precursor  
Size: 207 amino acids; 23989 Da
Subunit: Interacts with FGFR3 and FGFR4
Subcellular location: Secreted (By similarity)
Secondary accessions: D3DQL7 Q6UWF1

Explore the universe of human proteins at neXtProt for FGF18: NX_O76093

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O76093

    • FGF18 Protein expression data from MOPED and PaxDb:    About this image 
    FGF18 Protein Expression
    REFSEQ proteins: NP_003853.1  
    ENSEMBL proteins: 
     ENSP00000274625  
    Reactome Protein details: O76093
    Human Recombinant Protein Products for FGF18: 
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    Novus Biologicals FGF18 Lysates
    Sino Biological Recombinant Protein for FGF18
    ProSpec Recombinant Protein for FGF18
    Uscn Proteins for FGF18

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9742123
    GO:0005730nucleolus IDA--

    FGF18 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FGF18

    Protein Domains /
    Families
    for FGF18 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF18 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry O76093

    ProtoNet protein and cluster: O76093

    1 Blocks protein family: IPB002348 IL1/HBGF family signature

    UniProtKB/Swiss-Prot: FGF18_HUMAN, O76093
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF18 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF18_HUMAN, O76093
    Function: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration.
    Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation

         Genatlas biochemistry entry for FGF18:
    fibroblast growth factor 18,secreted signaling molecule in adult liver,lung,small intestine and developing tissues

         Summary:  
    During embryonic development, FGF18 as signaling molecule is secreted from the following cells: Endochondral Preosteoblasts in Sacral Vertebrae, Endochondral Preosteoblasts in Rostral Endochondral Facial Bones (see all 11).

    It affects the following cells: Chondrocytes in Lumbar Vertebrae, Chondrocytes in Branchial Arch 2 (see all 38).

    FGF18 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Immature proximal lung cells, Mature airway epithelial cells (see all 38).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005105type 1 fibroblast growth factor receptor binding IDA16384934
    GO:0005111type 2 fibroblast growth factor receptor binding IDA16384934
    GO:0008083growth factor activity IEA--
         
    FGF18 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fgf18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  growth/size 
     homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging  respiratory system 
     skeleton 

    FGF18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGF18 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF18
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF18 (see all 29):
    hsa-miR-34b* hsa-miR-3938 hsa-miR-429 hsa-miR-4328 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: FGF18 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF18 (see all 7)
    OriGene shRNA RFP: FGF18
    OriGene siRNA: FGF18
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    Sirion Biotech Custom design and validation of potent shRNA sequences against FGF18 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FGF18 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF18 (see all 3)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF18


    Pathways & Interactions
    for FGF18 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FGFR2c binds to FGF
    8/15 pathways (see all 15)
    		FGFR2c binds to FGF1.00
    		Activated point mutants of FGFR20.76
    		FGFR2c ligand binding and activation1.00
    		FGFR4 ligand binding and activation0.73
    		FGFR3c ligand binding and activation0.79
    		FGFR ligand binding and activation0.57
    		FGFR3 ligand binding and activation0.79
    		SHC-mediated cascade0.45
    2Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    3Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF18 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 BioSystems Pathways for FGF18 
        Regulation of Actin Cytoskeleton
    Endochondral Ossification

    5/54        Reactome Pathways for FGF18 (see all 54)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF18):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGF18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for FGF18 (O760933 ENSP000002746254) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR1P113623, ENSP000003802804I2D: score=1 STRING: ENSP00000380280
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGF10ENSP000002646644STRING: ENSP00000264664
    FGF19ENSP000002943124STRING: ENSP00000294312
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification ----
    GO:0001525angiogenesis IEA--
    GO:0001957intramembranous ossification IEA--
    GO:0001958endochondral ossification IEA--
    GO:0002063chondrocyte development IEA--

    FGF18 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF18 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF18 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF18
    1 Novoseek chemical compound relationship for FGF18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 26.1 1 15447937 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF18 

    Transcripts
    for FGF18 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF18 gene (2 alternative transcripts): 
    NM_003862.2  NM_033649.1  

    Unigene Cluster for FGF18:

    Fibroblast growth factor 18
    Hs.87191  [show with all ESTs]
    Unigene Representative Sequence: NM_003862
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274625(uc003mbk.3)

    miRNA
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    hsa-miR-34b* hsa-miR-3938 hsa-miR-429 hsa-miR-4328 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-29b-1*
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB007422.1 AF075292.1 AY358811.1 BC006245.2 BT019570.1 BT019571.1 

    3 DOTS entries:

    DT.442244  DT.40117784  DT.70102018 

    24/25 AceView cDNA sequences (see all 25):

    AI290400 AW301094 NM_033649 AA233904 BE550512 AF075292 BE741672 AY358811 
    NM_003862 BC006245 AI989645 AI239727 AI288265 AB007422 BQ018759 AF211188 
    BE271316 AW135119 BE315016 AI688649 AI927348 AI798863 BQ020931 AI054409 

    GeneLoc Exon Structure


    Expression
    for FGF18 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAATAAGG
    FGF18 Expression
    About this image

    FGF18 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneCaudal Endochondral BonesEndochondral PreosteoblastsBone
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneEndochondral Facial BonesEndochondral PreosteoblastsBone
    BoneLumbar VertebraeEndochondral PreosteoblastsBone
    BoneRostral Endochondral Facial BonesEndochondral PreosteoblastsBone
    BoneRostral Skull Membranous BonesIntramembrenous OsteocytesBone
    BoneSacral VertebraeEndochondral PreosteoblastsBone
    BoneStylopod Epiphyseal EndChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See FGF18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF18

    SOURCE GeneReport for Unigene cluster: Hs.87191
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    In Situ
    Assay Products:     
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    Orthologs
    for FGF18 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FGF18 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fgf181 , 5 fibroblast growth factor 181, 5 90.29(n)1
    99.03(a)1    		   11 (19.21 cM)5
    141721  NM_008005.11  NP_032031.11 
     331174305 
    chicken
    (Gallus gallus)    		 Aves FGF181 fibroblast growth factor 18 81.96(n)
    94.2(a)    		   395453  NM_204714.1  NP_990045.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF186
    		 --
    		 92(a)
    		 1 ↔ 1
    		 1(130385625-130461579)
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf182 fibroblast growth factor 18 81.09(n)   359829  AY243514.1 


    ENSEMBL Gene Tree for FGF18 (if available)
    TreeFam Gene Tree for FGF18 (if available) 

    Paralogs
    for FGF18 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF18 gene
    FGF172  FGF12  FGF82  FGF22  
    4 SIMAP similar genes for FGF18 using alignment to 1 protein entry:     FGF18_HUMAN:
    FGF17    FGF8    PRED3    FGF1

    FGF18 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF18 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/620 NCBI SNPs in FGF18 are shown (see all 620)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs77096731,2
    		C,F,A,H--170844678(+) GCAGAA/GTCTCA 1 -- us2k119Minor allele frequency- G:0.44NS EA NA WA CSA 2344
    rs1826876271,2
    		--170844738(+) ATGCAA/GTACTT 1 -- us2k10--------
    rs38405201,2
    		C--170844913(-) TTTTT-/TATTAC 1 -- us2k1 tfbs30--------
    rs38069291,2
    		C,F,A,H--170845059(-) TGACCC/TGAGTC 1 -- us2k120Minor allele frequency- T:0.46EA NS NA WA CSA 3428
    rs1858151111,2
    		--170845234(+) AATTTC/TCCCCC 1 -- us2k10--------
    rs1159652071,2
    		C--170845387(+) TTATAG/ATCATG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs38069281,2
    		C,F,H--170845548(-) AAGGAA/GAATAG 1 -- us2k16Minor allele frequency- G:0.00EA NS 2132
    rs1906177401,2
    		--170845573(+) GCAGAA/GCTTGG 1 -- us2k10--------
    rs1457802561,2
    		--170845586(+) GACACC/GAGCTC 1 -- us2k10--------
    rs623839781,2
    		C,F--170845692(+) AACCAG/ATGTCC 1 -- us2k18Minor allele frequency- A:0.45NA WA CSA EA 366

    HapMap Linkage Disequilibrium report for FGF18 (170846660 - 170884630 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FGF18
         1 Indel: 46806

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    DNA2.0 Custom Variant and Variant Library Synthesis for FGF18

    Disorders / Diseases
    for FGF18 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF18 for disorders           About GeneDecksing

    OMIM gene information: 603726    OMIM disorders: --

    17 diseases for FGF18:    About MalaCards
    cleft lip/palate    congenital diaphragmatic hernia    cleft lip    hernia
    achondroplasia    chronic lymphocytic leukemia    lymphocytic leukemia    teratocarcinoma
    hepatocellular carcinoma    colon cancer    leukemia    melanoma
    carcinoma    hepatitis    breast cancer    adenocarcinoma
    pancreatitis

    1 Novoseek disease relationship for FGF18 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 10353607 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF18 (6 documents)

    Export disorders for FGF18 gene to outside databases

    Publications
    for FGF18 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF18 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with FGF18)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. (PubMed id 9660775)1, 2, 3, 9 Ohbayashi N.... Ito N. (1998)
    2. FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. (PubMed id 9742123)1, 2, 3 Hu M.C.-T....Danilenko D.M. (1998)
    3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11. (PubMed id 10353607)1, 9 Hu M.C....Qiu W.R. (1999)
    7. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PubMed id 16756958)1, 9 Antoine M....Kiefer P. (2006)
    8. Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development. (PubMed id 15749088)1, 9 Cormier S....Silve C. (2005)
    9. Involvement of fibroblast growth factor 18 in dediffe rentiation of cultured human chondrocytes. (PubMed id 19909293)1, 9 Yamaoka H....Hoshi K. (2010)
    10. Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization. (PubMed id 11124520)1, 9 Whitmore T.E....Deisher T.A. (2000)

    External Searches for FGF18 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing FGF18 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8817 HGNC: 3674 AceView: FGF18 Ensembl:ENSG00000156427 euGenes: HUgn8817
    ECgene: FGF18 Kegg: 8817 H-InvDB: FGF18

    Other Databases showing FGF18 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGF18 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF18 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FGF18 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF18 gene:
    Search GeneIP for patents involving FGF18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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