Aliases for FGF18 Gene
External Ids for FGF18 Gene
- HGNC: 3674
- Entrez Gene: 8817
- Ensembl: ENSG00000156427
- OMIM: 603726
- UniProtKB: O76093
Previous GeneCards Identifiers for FGF18 Gene
- GC05P171049
- GC05P171549
- GC05P170782
- GC05P170827
- GC05P170779
- GC05P170846
- GC05P165944
Summaries for FGF18 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF18 Gene
FGF18 (Fibroblast Growth Factor 18) is a Protein Coding gene. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.
UniProtKB/Swiss-Prot for FGF18 Gene
-
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF18 Gene
Genomics for FGF18 Gene
Regulatory Elements for FGF18 Gene
Enhancers for FGF18 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G171449 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 11.8 | +31.0 | 30969 | 2.3 | KLF1 SUZ12 RBBP5 BCL11B FOSL1 E2F1 GLIS2 POLR2A FOS KLF7 | FGF18 SMIM23 LOC105377720 |
| GH05G171913 | 1.1 | Ensembl ENCODE dbSUPER | 11.6 | +494.8 | 494792 | 1.4 | ZNF692 SMARCA4 ZSCAN4 IKZF1 IKZF2 PRDM1 SPI1 | FGF18 ENSG00000253110 SMIM23 GC05P171872 FBXW11 |
| GH05G171953 | 1.3 | Ensembl ENCODE | 9.3 | +534.8 | 534754 | 2.8 | PKNOX1 ATF1 CREB3L1 ARNT FEZF1 TCF12 ZNF766 ELK1 GATA2 FOS | FGF18 FBXW11 GC05P171872 |
| GH05G171956 | 1.3 | Ensembl ENCODE dbSUPER | 9.3 | +537.8 | 537791 | 2.1 | SOX13 FOXA2 ZNF335 ZNF121 ARID3A FOXK2 FOS RELB IKZF2 ZNF362 | FGF18 FBXW11 GC05P171872 |
| GH05G171841 | 1 | Ensembl ENCODE | 10.9 | +422.6 | 422626 | 0.6 | ZBTB21 FOXK2 ZSCAN29 ZNF394 MNT ZEB2 ATF2 ZNF843 ARID1B OSR2 | ENSG00000253110 SMIM23 FGF18 LOC105377725 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGF18 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FGF18 gene promoter:
Regulatory Element Products
Genomic Location for FGF18 Gene
- Chromosome:
- 5
- Start:
- 171,419,656 bp from pter
- End:
- 171,457,626 bp from pter
- Size:
- 37,971 bases
- Orientation:
- Plus strand
Genomic View for FGF18 Gene
Genes around FGF18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.1 by Ensembl
- 5q35.1 by Entrez Gene
- 5q35.1 by HGNC
FGF18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF18 Gene
Proteins for FGF18 Gene
-
Protein details for FGF18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O76093-FGF18_HUMAN
- Recommended name:
- Fibroblast growth factor 18
- Protein Accession:
- O76093
- D3DQL7
- Q6UWF1
Protein attributes for FGF18 Gene
- Size:
- 207 amino acids
- Molecular mass:
- 23989 Da
- Quaternary structure:
-
- Interacts with FGFR3 and FGFR4.
Protein Expression for FGF18 Gene
Post-translational modifications for FGF18 Gene
Other Protein References for FGF18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Protein Products
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-
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-
Cloud-Clone Corp. Proteins for FGF18
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-
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-
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Assay Products
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No data available for DME Specific Peptides for FGF18 Gene
Domains & Families for FGF18 Gene
Protein Domains for FGF18 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF18 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O76093- Family:
-
- Belongs to the heparin-binding growth factors family.
No data available for Gene Families for FGF18 Gene
Function for FGF18 Gene
Molecular function for FGF18 Gene
- GENATLAS Biochemistry:
- fibroblast growth factor 18,secreted signaling molecule in adult liver,lung,small intestine and developing tissues
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
LifeMap Function Summary for FGF18 Gene
During embryonic development, FGF18 as signaling molecule is secreted from the following cells
-
Bone
- Endochondral Preosteoblasts (Endochondral Facial Bones)
- Endochondral Preosteoblasts (Rib)
- Endochondral Preosteoblasts (Stylopod Perichondrium)
- Endochondral Preosteoblasts (Rostral Endochondral Facial Bones)
- Endochondral Preosteoblasts (Zeugopod Perichondrium)
- Endochondral Preosteoblasts (Caudal Facial Endochondral Bones)
- Endochondral Preosteoblasts (Autopod Perichondrium)
- Endochondral Preosteoblasts (Vertebrae)
It affects the following cells:
-
Bone
- Chondrocytes (Stylopod Epiphyseal End)
- Chondrocytes (Zeugopod Epiphyseal End)
- Chondrocytes (Autopod Epiphyseal End)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Vertebrae)
- Hypertrophic Chondrocytes (Rib)
- Immature Endochondral Osteoblasts (Autopod Periosteum)
- Immature Endochondral Osteoblasts (Stylopod Periosteum)
- Immature Endochondral Osteoblasts (Zeugopod Periosteum)
- Intramembranous Osteoblasts (Rostral Skull Membranous Bones)
- Intramembranous Osteoblasts (Membranous Facial Bones)
- Intramembranous Preosteoblasts (Membranous Facial Bones)
- Intramembranous Preosteoblasts (Rostral Skull Membranous Bones)
- Intramembrenous Osteocytes (Rostral Skull Membranous Bones)
- Intramembrenous Osteocytes (Membranous Facial Bones)
- Prehypertrophic Chondrocytes (Stylopod Growth Plate)
- Prehypertrophic Chondrocytes (Zeugopod Growth Plate)
- Prehypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Autopod Growth Plate)
- Prehypertrophic Chondrocytes (Vertebrae)
- Prehypertrophic Chondrocytes (Vertebrae)
- Presumptive Suture Cells (Rostral Sutures)
- Presumptive Suture Cells (Facial Sutures)
- Suture Cells (Facial Sutures)
- Suture Cells (Rostral Sutures)
- Cartilage
- Head Mesenchyme
- Brain
FGF18 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Lung
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005104 | fibroblast growth factor receptor binding | IEA | -- |
| GO:0005105 | type 1 fibroblast growth factor receptor binding | IDA | 16384934 |
| GO:0005111 | type 2 fibroblast growth factor receptor binding | IDA | 16384934 |
Phenotypes for FGF18 Gene
- MGI mutant phenotypes for FGF18:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FGF18:
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ViGene Biosciences lentiviral particle packaged cDNA for FGF18 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGF18 Gene
Localization for FGF18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF18 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 4 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS | 9742123 |
| GO:0005730 | nucleolus | IDA | -- |
Pathways & Interactions for FGF18 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 4 | GPCR Pathway |
.73
.62
|
.55
|
| 5 | GAB1 signalosome |
.89
|
|
Pathways by source for FGF18 Gene
2 BioSystems pathways for FGF18 Gene
98 Reactome pathways for FGF18 Gene
8 KEGG pathways for FGF18 Gene
1 R&D Systems pathway for FGF18 Gene
Interacting Proteins for FGF18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001936 | NOT regulation of endothelial cell proliferation | IDA | 16756958 |
| GO:0001957 | intramembranous ossification | IEA | -- |
Drugs & Compounds for FGF18 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Mitogens | Pharma | 1617 |
Transcripts for FGF18 Gene
mRNA/cDNA for FGF18 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGF18 Gene
CRISPR Products
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Inhibitory RNA Products
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Expression for FGF18 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Intramembrenous Osteocytes Rostral Skull Membranous Bones
- Intramembranous Preosteoblasts Membranous Facial Bones
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
- Chondrocytes Stylopod Epiphyseal End
- Chondrocytes Autopod Epiphyseal End
- Sclerotome cells
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
- Optic Nerve
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
-
Somite (Muscoskeletal System)
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Sclerotome cells
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for FGF18 Gene
This gene is overexpressed in Heart - Left Ventricle (x12.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF18 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGF18 Gene:
FGF18SOURCE GeneReport for Unigene cluster for FGF18 Gene:
Hs.87191Evidence on tissue expression from TISSUES for FGF18 Gene
- Lung(4.3)
Primer Products
-
OriGene qPCR primer pairs for FGF18
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OriGene qPCR primer pairs and template standards for FGF18
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF18 Gene
Orthologs for FGF18 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGF18 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FGF18 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGF18 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FGF18 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgf18 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgf18 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGF18 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGF18 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGF18 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | fgf18a 34 35 |
|
||
| fgf18b 35 |
|
OneToMany | |||
| fgf24 35 |
|
OneToMany | |||
| fgf18 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FGF18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGF18 Gene
Variants for FGF18 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029617 | -- | 171,430,719(+) | GGAAG(C/T)GGAGC | intron-variant | |
| rs1000036535 | -- | 171,436,679(+) | GCCTA(-/GT)GTGTG | intron-variant | |
| rs1000295335 | -- | 171,441,757(+) | TCAGT(A/G)TATGC | intron-variant | |
| rs1000381030 | -- | 171,430,956(+) | GACAG(C/T)TAAGG | intron-variant | |
| rs1000418964 | -- | 171,443,323(+) | ACAGG(G/T)TTTCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2412659 | CNV | deletion | 18987734 |
| esv3570552 | CNV | loss | 25503493 |
| nsv1074347 | CNV | deletion | 25765185 |
| nsv1133617 | CNV | deletion | 24896259 |
| nsv475015 | CNV | novel sequence insertion | 20440878 |
| nsv600278 | CNV | loss | 21841781 |
| nsv600279 | CNV | loss | 21841781 |
| nsv600280 | CNV | loss | 21841781 |
| nsv830551 | CNV | loss | 17160897 |
| nsv830552 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.28;
6.23% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGF18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGF18
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF18 Gene
Disorders for FGF18 Gene
Relevant External Links for FGF18
No disorders were found for FGF18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGF18 Gene
Publications for FGF18 Gene
- Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. (PMID: 9660775) Ohbayashi N. … Ito N. (J. Biol. Chem. 1998) 2 3 4 22 64
- FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. (PMID: 9742123) Hu M.C.-T. … Danilenko D.M. (Mol. Cell. Biol. 1998) 2 3 4 64
- Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes. (PMID: 19909293) Yamaoka H. … Hoshi K. (Cell Prolif. 2010) 3 22 64
- Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 46 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
Products for FGF18 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGF18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer