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Aliases for FGF18 Gene

Aliases for FGF18 Gene

  • Fibroblast Growth Factor 18 2 3 5
  • FGF-18 3 4
  • ZFGF5 3 4

External Ids for FGF18 Gene

Previous GeneCards Identifiers for FGF18 Gene

  • GC05P171049
  • GC05P171549
  • GC05P170782
  • GC05P170827
  • GC05P170779
  • GC05P170846
  • GC05P165944

Summaries for FGF18 Gene

Entrez Gene Summary for FGF18 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF18 Gene

FGF18 (Fibroblast Growth Factor 18) is a Protein Coding gene. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.

UniProtKB/Swiss-Prot for FGF18 Gene

  • Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

Gene Wiki entry for FGF18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF18 Gene

Genomics for FGF18 Gene

Regulatory Elements for FGF18 Gene

Enhancers for FGF18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G171449 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +31.0 30969 2.3 KLF1 SUZ12 RBBP5 BCL11B FOSL1 E2F1 GLIS2 POLR2A FOS KLF7 FGF18 SMIM23 LOC105377720
GH05G171913 1.1 Ensembl ENCODE dbSUPER 11.6 +494.8 494792 1.4 ZNF692 SMARCA4 ZSCAN4 IKZF1 IKZF2 PRDM1 SPI1 FGF18 ENSG00000253110 SMIM23 GC05P171872 FBXW11
GH05G171953 1.3 Ensembl ENCODE 9.3 +534.8 534754 2.8 PKNOX1 ATF1 CREB3L1 ARNT FEZF1 TCF12 ZNF766 ELK1 GATA2 FOS FGF18 FBXW11 GC05P171872
GH05G171956 1.3 Ensembl ENCODE dbSUPER 9.3 +537.8 537791 2.1 SOX13 FOXA2 ZNF335 ZNF121 ARID3A FOXK2 FOS RELB IKZF2 ZNF362 FGF18 FBXW11 GC05P171872
GH05G171841 1 Ensembl ENCODE 10.9 +422.6 422626 0.6 ZBTB21 FOXK2 ZSCAN29 ZNF394 MNT ZEB2 ATF2 ZNF843 ARID1B OSR2 ENSG00000253110 SMIM23 FGF18 LOC105377725
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF18 on UCSC Golden Path with GeneCards custom track

Promoters for FGF18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190636 144 801 SIN3A KLF17 GLIS2 EGR1 EGR2 SP3 MTA1 ZBTB33 ZBTB26 SP7
ENSR00000318524 -756 201 HDGF ATF1 RB1 SIN3A RAD21 GLIS2 ZNF143 CREM EGR2 ZNF654

Genomic Location for FGF18 Gene

Chromosome:
5
Start:
171,419,656 bp from pter
End:
171,457,626 bp from pter
Size:
37,971 bases
Orientation:
Plus strand

Genomic View for FGF18 Gene

Genes around FGF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF18 Gene

Proteins for FGF18 Gene

  • Protein details for FGF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76093-FGF18_HUMAN
    Recommended name:
    Fibroblast growth factor 18
    Protein Accession:
    O76093
    Secondary Accessions:
    • D3DQL7
    • Q6UWF1

    Protein attributes for FGF18 Gene

    Size:
    207 amino acids
    Molecular mass:
    23989 Da
    Quaternary structure:
    • Interacts with FGFR3 and FGFR4.

    Three dimensional structures from OCA and Proteopedia for FGF18 Gene

neXtProt entry for FGF18 Gene

Post-translational modifications for FGF18 Gene

  • Glycosylation at Asn39 and Asn137
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FGF18
  • Santa Cruz Biotechnology (SCBT) Antibodies for FGF18

Protein Products

  • Abcam proteins for FGF18

No data available for DME Specific Peptides for FGF18 Gene

Domains & Families for FGF18 Gene

Protein Domains for FGF18 Gene

Suggested Antigen Peptide Sequences for FGF18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76093

UniProtKB/Swiss-Prot:

FGF18_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF18: view

No data available for Gene Families for FGF18 Gene

Function for FGF18 Gene

Molecular function for FGF18 Gene

GENATLAS Biochemistry:
fibroblast growth factor 18,secreted signaling molecule in adult liver,lung,small intestine and developing tissues
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

LifeMap Function Summary for FGF18 Gene

It affects the following cells:
FGF18 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005105 type 1 fibroblast growth factor receptor binding IDA 16384934
GO:0005111 type 2 fibroblast growth factor receptor binding IDA 16384934
genes like me logo Genes that share ontologies with FGF18: view
genes like me logo Genes that share phenotypes with FGF18: view

Animal Models for FGF18 Gene

MGI Knock Outs for FGF18:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGF18 Gene

Localization for FGF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF18 gene
Compartment Confidence
extracellular 5
nucleus 4
lysosome 1

Gene Ontology (GO) - Cellular Components for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9742123
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with FGF18: view

Pathways & Interactions for FGF18 Gene

SuperPathways for FGF18 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 GPCR Pathway
5 GAB1 signalosome
genes like me logo Genes that share pathways with FGF18: view

SIGNOR curated interactions for FGF18 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001503 ossification IEA --
GO:0001525 angiogenesis IEA --
GO:0001936 NOT regulation of endothelial cell proliferation IDA 16756958
GO:0001957 intramembranous ossification IEA --
genes like me logo Genes that share ontologies with FGF18: view

Drugs & Compounds for FGF18 Gene

(2) Drugs for FGF18 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitogens Pharma 1617
genes like me logo Genes that share compounds with FGF18: view

Transcripts for FGF18 Gene

mRNA/cDNA for FGF18 Gene

Unigene Clusters for FGF18 Gene

Fibroblast growth factor 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF18 Gene

No ASD Table

Relevant External Links for FGF18 Gene

GeneLoc Exon Structure for
FGF18
ECgene alternative splicing isoforms for
FGF18

Expression for FGF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF18 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF18 Gene



NURSA nuclear receptor signaling pathways regulating expression of FGF18 Gene:

FGF18

SOURCE GeneReport for Unigene cluster for FGF18 Gene:

Hs.87191

Evidence on tissue expression from TISSUES for FGF18 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with FGF18: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF18 Gene

Orthologs for FGF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF18 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF18 34 35
  • 95.17 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF18 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF18 34 35
  • 94.52 (n)
mouse
(Mus musculus)
Mammalia Fgf18 34 16 35
  • 90.18 (n)
rat
(Rattus norvegicus)
Mammalia Fgf18 34
  • 90.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FGF18 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF18 34 35
  • 81.96 (n)
lizard
(Anolis carolinensis)
Reptilia FGF18 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgf18a 34 35
  • 72.69 (n)
fgf18b 35
  • 61 (a)
OneToMany
fgf24 35
  • 59 (a)
OneToMany
fgf18 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
OneToMany
Species where no ortholog for FGF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF18 Gene

ENSEMBL:
Gene Tree for FGF18 (if available)
TreeFam:
Gene Tree for FGF18 (if available)

Paralogs for FGF18 Gene

Paralogs for FGF18 Gene

(4) SIMAP similar genes for FGF18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF18: view

Variants for FGF18 Gene

Sequence variations from dbSNP and Humsavar for FGF18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000029617 -- 171,430,719(+) GGAAG(C/T)GGAGC intron-variant
rs1000036535 -- 171,436,679(+) GCCTA(-/GT)GTGTG intron-variant
rs1000295335 -- 171,441,757(+) TCAGT(A/G)TATGC intron-variant
rs1000381030 -- 171,430,956(+) GACAG(C/T)TAAGG intron-variant
rs1000418964 -- 171,443,323(+) ACAGG(G/T)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF18 Gene

Variant ID Type Subtype PubMed ID
esv2412659 CNV deletion 18987734
esv3570552 CNV loss 25503493
nsv1074347 CNV deletion 25765185
nsv1133617 CNV deletion 24896259
nsv475015 CNV novel sequence insertion 20440878
nsv600278 CNV loss 21841781
nsv600279 CNV loss 21841781
nsv600280 CNV loss 21841781
nsv830551 CNV loss 17160897
nsv830552 CNV gain 17160897

Variation tolerance for FGF18 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF18 Gene

Disorders for FGF18 Gene

Relevant External Links for FGF18

Genetic Association Database (GAD)
FGF18
Human Genome Epidemiology (HuGE) Navigator
FGF18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF18

No disorders were found for FGF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGF18 Gene

Publications for FGF18 Gene

  1. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. (PMID: 9660775) Ohbayashi N. … Ito N. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. (PMID: 9742123) Hu M.C.-T. … Danilenko D.M. (Mol. Cell. Biol. 1998) 2 3 4 64
  3. Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes. (PMID: 19909293) Yamaoka H. … Hoshi K. (Cell Prolif. 2010) 3 22 64
  4. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 46 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for FGF18 Gene

Sources for FGF18 Gene

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