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Aliases for FGF18 Gene

Aliases for FGF18 Gene

  • Fibroblast Growth Factor 18 2 3 5
  • FGF-18 3 4
  • ZFGF5 3 4

External Ids for FGF18 Gene

Previous GeneCards Identifiers for FGF18 Gene

  • GC05P171049
  • GC05P171549
  • GC05P170782
  • GC05P170827
  • GC05P170779
  • GC05P170846
  • GC05P165944

Summaries for FGF18 Gene

Entrez Gene Summary for FGF18 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF18 Gene

FGF18 (Fibroblast Growth Factor 18) is a Protein Coding gene. Diseases associated with FGF18 include congenital diaphragmatic hernia. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.

UniProtKB/Swiss-Prot for FGF18 Gene

  • Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

Gene Wiki entry for FGF18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF18 Gene

Genomics for FGF18 Gene

Regulatory Elements for FGF18 Gene

Promoters for FGF18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGF18 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGF18 Gene

Chromosome:
5
Start:
171,419,656 bp from pter
End:
171,457,626 bp from pter
Size:
37,971 bases
Orientation:
Plus strand

Genomic View for FGF18 Gene

Genes around FGF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF18 Gene

Proteins for FGF18 Gene

  • Protein details for FGF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76093-FGF18_HUMAN
    Recommended name:
    Fibroblast growth factor 18
    Protein Accession:
    O76093
    Secondary Accessions:
    • D3DQL7
    • Q6UWF1

    Protein attributes for FGF18 Gene

    Size:
    207 amino acids
    Molecular mass:
    23989 Da
    Quaternary structure:
    • Interacts with FGFR3 and FGFR4.

    Three dimensional structures from OCA and Proteopedia for FGF18 Gene

neXtProt entry for FGF18 Gene

Proteomics data for FGF18 Gene at MOPED

Post-translational modifications for FGF18 Gene

  • Glycosylation at Asn 39 and Asn 137
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF18 Gene

Domains & Families for FGF18 Gene

Protein Domains for FGF18 Gene

Suggested Antigen Peptide Sequences for FGF18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76093

UniProtKB/Swiss-Prot:

FGF18_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF18: view

No data available for Gene Families for FGF18 Gene

Function for FGF18 Gene

Molecular function for FGF18 Gene

GENATLAS Biochemistry:
fibroblast growth factor 18,secreted signaling molecule in adult liver,lung,small intestine and developing tissues
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

LifeMap Function Summary for FGF18 Gene

It affects the following cells:
FGF18 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
genes like me logo Genes that share phenotypes with FGF18: view

Animal Models for FGF18 Gene

MGI Knock Outs for FGF18:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGF18 Gene

Localization for FGF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF18 Gene COMPARTMENTS Subcellular localization image for FGF18 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FGF18 Gene

Pathways & Interactions for FGF18 Gene

SuperPathways for FGF18 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K events in ERBB4 signaling
4 SHC-mediated cascade-FGFR4
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF18: view

SIGNOR curated interactions for FGF18 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001525 angiogenesis IEA --
GO:0001936 NOT regulation of endothelial cell proliferation IDA 16756958
GO:0001958 endochondral ossification IEA --
genes like me logo Genes that share ontologies with FGF18: view

Drugs & Compounds for FGF18 Gene

(2) Drugs for FGF18 Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitogens Pharma 1386
genes like me logo Genes that share compounds with FGF18: view

Transcripts for FGF18 Gene

mRNA/cDNA for FGF18 Gene

Unigene Clusters for FGF18 Gene

Fibroblast growth factor 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF18 Gene

No ASD Table

Relevant External Links for FGF18 Gene

GeneLoc Exon Structure for
FGF18
ECgene alternative splicing isoforms for
FGF18

Expression for FGF18 Gene

mRNA expression in normal human tissues for FGF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF18 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF18 Gene



SOURCE GeneReport for Unigene cluster for FGF18 Gene Hs.87191

genes like me logo Genes that share expression patterns with FGF18: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FGF18 Gene

Orthologs for FGF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF18 36
  • 99 (a)
OneToOne
FGF18 35
  • 94.52 (n)
  • 98.07 (a)
dog
(Canis familiaris)
Mammalia FGF18 35
  • 95.17 (n)
  • 98.55 (a)
FGF18 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf18 16
Fgf18 36
  • 99 (a)
OneToOne
Fgf18 35
  • 90.18 (n)
  • 98.55 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF18 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF18 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf18 35
  • 90.02 (n)
  • 98.55 (a)
chicken
(Gallus gallus)
Aves FGF18 35
  • 81.96 (n)
  • 94.2 (a)
FGF18 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF18 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgf18a 36
  • 64 (a)
OneToMany
fgf18b 36
  • 61 (a)
OneToMany
fgf24 36
  • 59 (a)
OneToMany
fgf18 35
fgf18a 35
  • 72.69 (n)
  • 75.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for FGF18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF18 Gene

ENSEMBL:
Gene Tree for FGF18 (if available)
TreeFam:
Gene Tree for FGF18 (if available)

Paralogs for FGF18 Gene

Paralogs for FGF18 Gene

(4) SIMAP similar genes for FGF18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF18: view

Variants for FGF18 Gene

Sequence variations from dbSNP and Humsavar for FGF18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2043278 -- 171,455,603(-) CAAAG(C/T)CAAGG intron-variant
rs4074237 -- 171,436,649(+) CTTTT(A/T)GGAAG intron-variant
rs4076077 -- 171,436,505(+) TTGGC(C/T)GGTAA intron-variant
rs3806927 -- 171,418,988(-) GCTCC(A/C/G)GGGCA upstream-variant-2KB
rs3822662 -- 171,419,147(-) CGAGA(A/G)GGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FGF18 Gene

Variant ID Type Subtype PubMed ID
nsv830551 CNV Loss 17160897
nsv830552 CNV Gain 17160897
esv2412659 CNV Deletion 18987734

Variation tolerance for FGF18 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF18 Gene

HapMap Linkage Disequilibrium report
FGF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF18 Gene

Disorders for FGF18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGF18 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital diaphragmatic hernia
  • diaphragmatic hernia
- elite association - COSMIC cancer census association via MalaCards
Search FGF18 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF18

Genetic Association Database (GAD)
FGF18
Human Genome Epidemiology (HuGE) Navigator
FGF18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF18
genes like me logo Genes that share disorders with FGF18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF18 Gene

Publications for FGF18 Gene

  1. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. (PMID: 9660775) Ohbayashi N. … Ito N. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes. (PMID: 19909293) Yamaoka H. … Hoshi K. (Cell Prolif. 2010) 3 23
  3. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PMID: 16756958) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development. (PMID: 15749088) Cormier S. … Silve C. (Gene Expr. Patterns 2005) 3 23
  5. Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization. (PMID: 11124520) Whitmore T.E. … Deisher T.A. (Cytogenet. Cell Genet. 2000) 3 23

Products for FGF18 Gene

Sources for FGF18 Gene

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