External Ids for FGF18 Gene
Previous GeneCards Identifiers for FGF18 Gene
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF18 Gene
FGF18 (Fibroblast Growth Factor 18) is a Protein Coding gene. Diseases associated with FGF18 include Congenital Diaphragmatic Hernia and Endometrial Cancer. Among its related pathways are RET signaling and Downstream signaling of activated FGFR2. GO annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.
UniProtKB/Swiss-Prot for FGF18 Gene
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.