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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF17 Gene

protein-coding GIFtS: 57
GCID: GC08P021899

fibroblast growth factor 17

Explore 12 diseases affiliated with
FGF17 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 17¹ ²
FGF-13¹ ²
FGF-17² ³

External Ids:	HGNC: 3673¹	Entrez Gene: 8822²	Ensembl: ENSG00000158815⁷	OMIM: 603725⁵	UniProtKB: O60258³

Export aliases for FGF17 gene to outside databases

Previous GC identifers: GC08P021659 GC08P022253 GC08P021720 GC08P021922 GC08P021956 GC08P020442

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF17:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes including

embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be

prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in

the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries,

which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in

reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258

Function: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction

and patterning of the embryonic brain. Required for normal brain development

Gene Wiki entry for FGF17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF17 gene promoter:
TBP AML1a p53 AP-1 ATF-2 MyoD N-Myc TFIID c-Jun Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF17 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF17

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.3

FGF17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF17 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P021899: view genomic region (about GC identifiers)

Start:	21,899,909 bp from pter	End:	21,906,320 bp from pter
Size:	6,412 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258 (See protein sequence)

Recommended Name: Fibroblast growth factor 17 precursor

Size: 216 amino acids; 24891 Da

Subunit: Interacts with FGFR3 and FGFR4

Subcellular location: Secreted

Developmental stage: Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the

neuroepithelia of the isthmus and septum of the embryonic brain at E14.5

Secondary accessions: B7ZLG4 Q2M2W1

Alternative splicing: 2 isoforms: O60258-1 O60258-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FGF17: NX_O60258

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60258

FGF17 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003858.1

ENSEMBL proteins:

ENSP00000431041 ENSP00000352414

Reactome Protein details: O60258
Human Recombinant Protein Products:

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	Novus Biologicals FGF17 Protein Novus Biologicals FGF17 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FGF17

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	TAS	9514906

FGF17 for ontologies About GeneDecksing

FGF17 Antibody Products:

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	Search for Antibodies for FGF17 at Abcam
	Uscn Antibodies for FGF17
	Search ThermoFisher Antibodies for FGF17

Assay Products for FGF17:

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	Uscn ELISAs and CLIAs for FGF17

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF17 for domains About GeneDecksing

2 InterPro domains/families:

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

Graphical View of Domain Structure for InterPro Entry O60258

ProtoNet protein and cluster: O60258

1 Blocks protein family: IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258

Function: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction

and patterning of the embryonic brain. Required for normal brain development

Genatlas biochemistry entry for FGF17:

fibroblast growth factor 17,secreted signaling molecule in the induction and patterning of the embryonic brain

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF17
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF17:
		hsa-miR-1266 hsa-miR-522 hsa-miR-155* hsa-miR-224*
		SwitchGear 3'UTR luciferase reporter plasmid: FGF17 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF17 (see all 7) OriGene shRNA RFP: FGF17 OriGene siRNA: FGF17
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF17

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FGF17

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		GenScript: all cDNA clones in your preferred vector: FGF17 (NM_003867)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF17
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF17

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGF17
		Search LifeMap BioReagents cell lines for FGF17

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FGF17

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005105	type 1 fibroblast growth factor receptor binding	IDA	16384934
GO:0005111	type 2 fibroblast growth factor receptor binding	IDA	16384934
GO:0008083	growth factor activity	IEA	--

FGF17 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FGF17:

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Fgf17^tm1Dor for FGF17
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fgf17):

behavior/neurological

nervous system

FGF17 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

FGFR2c binds to FGF

8/18 pathways (see all 18)
FGFR2c binds to FGF	1.00	FGFR4 ligand binding and activation	0.73
FGFR2c ligand binding and activation	1.00	FGFR1c ligand binding and activation	0.71
FGFR3c ligand binding and activation	0.79	Signaling by activated point mutants of FGFR1	0.71
FGFR3 ligand binding and activation	0.79	FGFR1 ligand binding and activation	0.59

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF17 (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for FGF17

Regulation of Actin Cytoskeleton

5/58 Reactome Pathways for FGF17 (see all 58)

	FGFR2 ligand binding and activation
	FGFR ligand binding and activation
	Signaling by EGFR in Cancer
	Signaling by FGFR2 mutants
	Downstream signal transduction

4 Kegg Pathways (Kegg details for FGF17):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF17 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FGF17

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for FGF17 (O60258³ ENSP00000352414⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR4	P22455³, ENSP00000292408⁴	I2D: score=1 STRING: ENSP00000292408
FGFR3	P22607³, ENSP00000260795⁴	I2D: score=1 STRING: ENSP00000260795
EGFR	ENSP00000275493⁴	STRING: ENSP00000275493
IGF1R	ENSP00000268035⁴	STRING: ENSP00000268035
MET	ENSP00000317272⁴	STRING: ENSP00000317272

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9514906
GO:0007267	cell-cell signaling	TAS	9514906
GO:0007399	nervous system development	TAS	9514906
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0008286	insulin receptor signaling pathway	TAS	--

FGF17 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF17
Search CenterWatch for drugs/clinical trials and news about FGF17

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF17 gene:

NM_003867.2

Unigene Cluster for FGF17:

Fibroblast growth factor 17

Hs.248192 [show with all ESTs]

Unigene Representative Sequence: NM_003867

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000518533 ENST00000359441(uc003xag.3 uc003xah.3) ENST00000521709

ENST00000524314(uc003xai.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF17
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF17:
		hsa-miR-1266 hsa-miR-522 hsa-miR-155* hsa-miR-224*
		SwitchGear 3'UTR luciferase reporter plasmid: FGF17 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF17 (see all 7) OriGene shRNA RFP: FGF17 OriGene siRNA: FGF17
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF17

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF17 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF17 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FGF17 (NM_003867)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF17
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF17
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF17

Additional cDNA sequence:

AB009249.1 AY358869.1 BC069475.1 BC105131.1 BC113489.1 BC143789.1

4 DOTS entries:

DT.92010200 DT.121467959 DT.101977180 DT.40211465

10 AceView cDNA sequences:

BC069475 AB009249 NM_003867 BM666883 BM695109 AX747108 AK091643 AY358869

AA323008 BM701642

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FGF17 About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c
SP1:			-		-
SP2:			-		-		-
SP3:					-		-				-
SP4:

ECgene alternative splicing isoforms for FGF17

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTCACGC

About this image

FGF17 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Ectoderm

Apical Ectodermal Ridge Cells

Selective marker (cell-identifying gene)

Dermis, Ectoderm

Head Mesenchyme

Frontonasal Process

Head Mesenchyme

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

See FGF17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF17

SOURCE GeneReport for Unigene cluster: Hs.248192

UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258

Tissue specificity: Preferentially expressed in the embryonic brain

SABiosciences Expression via Pathway-Focused PCR Array including FGF17:

Growth Factors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF17

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FGF17

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FGF17 gene from 1/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	Dr.29087²	Danio rerio fibroblast growth factor 17b (fgf17b) mRNA, more	77.98(n)		AY457142.1

ENSEMBL Gene Tree for FGF17 (if available)
TreeFam Gene Tree for FGF17 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF17 gene

FGF1² FGF8² FGF18² FGF2²

2 SIMAP similar genes for FGF17 using alignment to 1 protein entry: FGF17_HUMAN:

FGF18 FGF8

FGF17 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117406155^1,2	C,F,	--	21898466(+)	`GGATCC/TGCAGG`	1	--	us2k¹		1		NA	120
rs747801^1,2	C,F,A,H,	--	21898473(+)	`CAGGGG/AGAAAG`	1	--	us2k¹ trp³		19		NS EA NA WA CSA	2341
rs146056156^1,2		--	21898605(+)	`CAAATC/GATGAA`	1	--	us2k¹		0	--	--	--	--
rs2077478^1,2	C,F,A,H,	--	21898613(+)	`GAATCC/TCTAAG`	1	--	us2k¹		26		NS EA NA WA CSA	3175
rs140037096^1,2		--	21898615(+)	`ATCCCC/TAAGAC`	1	--	us2k¹		0	--	--	--	--
rs3176251^1,2	C,F,	--	21898712(+)	`CCACAC/GAAGCT`	1	--	us2k¹		1		NS	174
rs144368159^1,2		--	21898734(+)	`ACTCC-/TGAG TGGGC`	1	--	us2k¹		0	--	--	--	--
rs3176252^1,2	C,F	--	21898736(+)	`TCCTG-/AGTG GGCTG`	1	--	us2k¹		1		NS	174
rs1843086^1,2	C,F,A,	--	21898763(+)	`CCTGCG/AGAGAG`	1	--	us2k¹ trp³		10		NS NA WA CSA EA	538
rs190983091^1,2		--	21898777(+)	`ACCCCA/GGAGCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGF17 (21899909 - 21906320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FGF17
3 CNVs: 2746 3726 4586

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF17

DNA2.0 Custom Variant and Variant Library Synthesis for FGF17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGF17 for disorders           About GeneDecksing

OMIM gene information: 603725    OMIM disorders: --

12 diseases for FGF17:    About MalaCards

chronic lymphocytic leukemia hypotrichosis lymphocytic leukemia hepatocellular carcinoma

leukemia prostatitis prostate cancer breast cancer

melanoma carcinoma adenocarcinoma pancreatitis

1 Novoseek disease relationship for FGF17 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
benign prostatic hyperplasia	44.6	1	15129425 (1)

Human Genome Epidemiology (HuGE) Navigator: FGF17 (2 documents)

Export disorders for FGF17 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FGF17 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with FGF17)

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Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. (PubMed id 9514906)^{1, 2, 3, 9} Hoshikawa M.... Itoh N. (1998)
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)^{1, 2} Zhang X....Ornitz D.M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Identification and characterization of a novel member of the fibroblast growth factor family. (PubMed id 9751161)^{1, 3} Greene J.M....Alderson R.F. (1998)
FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia. (PubMed id 15129425)^{1, 9} Polnaszek N....Ittmann M. (2004)
Genomic structure, mapping, activity and expression of fibroblast growth factor 17. (PubMed id 10381577)^{1, 9} Xu J....Ornitz D.M. (1999)
Up-regulation of the fibroblast growth factor 8 subfa mily in human hepatocellular carcinoma for cell survival and neoangiogenesis. (PubMed id 21319186)¹ Gauglhofer C....Grasl-Kraupp B. (2011)
Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)¹ Casabonne D....de Sanjose S. (2010)
Fibroblast growth factor signalling: from development to cancer. (PubMed id 20094046)² Turner N. and Grose R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8822	HGNC: 3673	AceView: FGF17	Ensembl:ENSG00000158815	euGenes: HUgn8822
ECgene: FGF17	Kegg: 8822	H-InvDB: FGF17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FGF17	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF17	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf17/

Intellectual Property for FGF17 gene
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Patent Information for FGF17 gene:
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fibroblast growth factor 17

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