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FGF17 Gene

protein-coding   GIFtS: 63
GCID: GC08P021899

Fibroblast Growth Factor 17

  See FGF17-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 171 2
FGF-172 3
HH202 5
FGF-132

External Ids:    HGNC: 36731   Entrez Gene: 88222   Ensembl: ENSG000001588157   OMIM: 6037255   UniProtKB: O602583   

Export aliases for FGF17 gene to outside databases

Previous GC identifers: GC08P021659 GC08P022253 GC08P021720 GC08P021922 GC08P021956 GC08P020442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF17 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes
including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized
to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing
skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development.
This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization
are identical to FGF17. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF17 Gene:
FGF17 (fibroblast growth factor 17) is a protein-coding gene. Diseases associated with FGF17 include hypogonadotropic hypogonadism 20 with or without anosmia, and hypogonadotropic hypogonadism 17 with or without anosmia. GO annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.

UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258
Function: Plays an important role in the regulation of embryonic development and as signaling molecule in the
induction and patterning of the embryonic brain. Required for normal brain development

Gene Wiki entry for FGF17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF17 gene promoter:
         TBP   AML1a   p53   AP-1   ATF-2   MyoD   N-Myc   TFIID   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF17 promoter sequence
   Search Chromatin IP Primers for FGF17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

FGF17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF17 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P021899:  view genomic region     (about GC identifiers)

Start:
21,899,909 bp from pter      End:
21,906,320 bp from pter
Size:
6,412 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258 (See protein sequence)
Recommended Name: Fibroblast growth factor 17 precursor  
Size: 216 amino acids; 24891 Da
Subunit: Interacts with FGFR3 and FGFR4
Developmental stage: Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the
neuroepithelia of the isthmus and septum of the embryonic brain at E14.5
Secondary accessions: B7ZLG4 Q2M2W1
Alternative splicing: 2 isoforms:  O60258-1   O60258-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FGF17: NX_O60258

Explore proteomics data for FGF17 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn137

  • See FGF17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003858.1  
    ENSEMBL proteins: 
     ENSP00000431041   ENSP00000352414  
    Reactome Protein details: O60258

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    antibodies-online proteins for FGF17 (13 products) 

     
    antibodies-online peptides for FGF17

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    antibodies-online antibodies for FGF17 (41 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028287 FGF17

    Graphical View of Domain Structure for InterPro Entry O60258

    ProtoNet protein and cluster: O60258

    1 Blocks protein domain: IPB002348 IL1/HBGF family signature

    UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF17_HUMAN, O60258
    Function: Plays an important role in the regulation of embryonic development and as signaling molecule in the
    induction and patterning of the embryonic brain. Required for normal brain development

         Genatlas biochemistry entry for FGF17:
    fibroblast growth factor 17,secreted signaling molecule in the induction and patterning of the embryonic brain

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005105type 1 fibroblast growth factor receptor binding IDA16384934
    GO:0005111type 2 fibroblast growth factor receptor binding IDA16384934
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with FGF17           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF17:
     Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf17):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with FGF17           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fgf17tm1Dor for FGF17

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF17
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF17

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    hsa-mir-335-5p (MIRT018870)

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    hsa-miR-1266 hsa-miR-522 hsa-miR-155* hsa-miR-224*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF17_HUMAN, O60258: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9514906

    Find genes that share ontologies with FGF17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF17 About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00


    Find genes that share SuperPaths with FGF17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF17 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF17
        Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF17 (see all 18)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    Negative regulation of FGFR signaling
    Activated point mutants of FGFR2


    Selected Kegg Pathways  (Kegg details for FGF17) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF17: 
              Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FGF17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FGF17 (O602583 ENSP000003524144) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    EGFRENSP000002754934STRING: ENSP00000275493
    IGF1RENSP000002680354STRING: ENSP00000268035
    METENSP000003172724STRING: ENSP00000317272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9514906
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS9514906
    GO:0007399nervous system development TAS9514906
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with FGF17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF17



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF17 gene: 
    NM_003867.2  

    Unigene Cluster for FGF17:

    Fibroblast growth factor 17
    Hs.248192  [show with all ESTs]
    Unigene Representative Sequence: NM_003867
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518533 ENST00000359441(uc003xag.3 uc003xah.3) ENST00000521709
    ENST00000524314(uc003xai.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate FGF17:
    hsa-miR-1266 hsa-miR-522 hsa-miR-155* hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidFGF17 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB009249.1 AY358869.1 BC069475.1 BC105131.1 BC113489.1 BC143789.1 

    4 DOTS entries:

    DT.92010200  DT.121467959  DT.101977180  DT.40211465 

    10 AceView cDNA sequences:

    AB009249 BM666883 AX747108 BM695109 NM_003867 AK091643 BC069475 BM701642 
    AA323008 AY358869 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FGF17    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
    SP1:        -     -                                       
    SP2:        -     -     -                                 
    SP3:              -     -           -                     
    SP4:                                                      


    ECgene alternative splicing isoforms for FGF17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTCACGC
    FGF17 Expression
    About this image


    FGF17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Ectoderm (Gastrulation Derivatives)
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Limb (Muscoskeletal System)
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    FGF17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248192

    UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258
    Tissue specificity: Preferentially expressed in the embryonic brain

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF17: 
              Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF17 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf171 , 5 fibroblast growth factor 171, 5 91.51(n)1
    98.61(a)1
      14 (36.40 cM)5
    141711  NM_008004.41  NP_032030.11 
     706362055 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290872 Danio rerio fibroblast growth factor 17b (fgf17b) mRNA, more 77.98(n)    AY457142.1 


    ENSEMBL Gene Tree for FGF17 (if available)
    TreeFam Gene Tree for FGF17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF17 gene
    FGF82  FGF182  
    2 SIMAP similar genes for FGF17 using alignment to 1 protein entry:     FGF17_HUMAN:
    FGF18    FGF8

    Find genes that share paralogs with FGF17           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF17 (see all 232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0699474
    Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)4--see VAR_0699472 I T mis40--------
    VAR_0699484
    Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)4--see VAR_0699482 R H mis40--------
    VAR_0699494
    Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)4--see VAR_0699492 N S mis40--------
    rs1174061551,2
    C,F--21898466(+) GGATCC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.04NA 120
    rs7478011,2
    C,F,A,H--21898473(+) CAGGGG/AGAAAG 1 -- us2k1 trp319Minor allele frequency- A:0.37NS EA NA WA CSA 2341
    rs1460561561,2
    C--21898605(+) CAAATC/GATGAA 1 -- us2k10--------
    rs20774781,2
    C,F,A,H--21898613(+) GAATCC/TCTAAG 1 -- us2k126Minor allele frequency- T:0.36NS EA NA WA CSA 3175
    rs1400370961,2
    --21898615(+) ATCCCC/TAAGAC 1 -- us2k10--------
    rs31762511,2
    C,F--21898712(+) CCACAC/GAAGCT 1 -- us2k11Minor allele frequency- G:0.04NS 174
    rs1443681591,2
    C--21898734(+) ACTCC-/TGAG  
            
    TGGGC
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGF17 (21899909 - 21906320 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FGF17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890654CNV Loss21882294
    nsv528590CNV Loss19592680
    nsv465613CNV Loss19166990
    nsv831263CNV Loss17160897
    dgv7756n71CNV Loss21882294
    dgv7757n71CNV Loss21882294
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850

    Human Gene Mutation Database (HGMD): FGF17
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF17
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603725   
    OMIM disorders: 615270  
    UniProtKB/Swiss-Prot: FGF17_HUMAN, O60258
  • Hypogonadotropic hypogonadism 20 with or without anosmia (HH20) [MIM:615270]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations
    in FGF17 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FLRT3 (PubMed:23643382)

  • 3 diseases for FGF17:    
    About MalaCards
    hypogonadotropic hypogonadism 20 with or without anosmia    hypogonadotropic hypogonadism 17 with or without anosmia    hypogonadotropic hypogonadism 8 with or without anosmia


    Find genes that share disorders with FGF17           About GenesLikeMe

    1 Novoseek inferred disease relationship for FGF17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benign prostatic hyperplasia 44.6 1 15129425 (1)

    Genetic Association Database (GAD): FGF17
    Human Genome Epidemiology (HuGE) Navigator: FGF17 (2 documents)

    Export disorders for FGF17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF17 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with FGF17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. (PubMed id 9514906)1, 2, 3, 9 Hoshikawa M.... Itoh N. (Biochem. Biophys. Res. Commun. 1998)
    2. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. (PubMed id 23643382)1, 2 Miraoui H....Pitteloud N. (Am. J. Hum. Genet. 2013)
    3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (J. Biol. Chem. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Identification and characterization of a novel member of the fibroblast growth factor family. (PubMed id 9751161)1, 3 Greene J.M....Alderson R.F. (Eur. J. Neurosci. 1998)
    7. FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia. (PubMed id 15129425)1, 9 Polnaszek N....Ittmann M. (Prostate 2004)
    8. Genomic structure, mapping, activity and expression of fibroblast growth factor 17. (PubMed id 10381577)1, 9 Xu J....Ornitz D.M. (Mech. Dev. 1999)
    9. Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis. (PubMed id 21319186)1 Gauglhofer C....Grasl-Kraupp B. (Hepatology 2011)
    10. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8822 HGNC: 3673 AceView: FGF17 Ensembl:ENSG00000158815 euGenes: HUgn8822
    ECgene: FGF17 Kegg: 8822 H-InvDB: FGF17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGF17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF17 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf17/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF17 gene:
    Search GeneIP for patents involving FGF17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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