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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF16 Gene

protein-coding   GIFtS: 51
GCID: GC0XP076709

fibroblast growth factor 16
 Explore 4 diseases affiliated with
FGF16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGF16    

Aliases
for FGF16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor 161 2
FGF-162 3

External Ids:    HGNC: 36721   Entrez Gene: 88232   Ensembl: ENSG000001964687   OMIM: 3008275   UniProtKB: O433203   

Export aliases for FGF16 gene to outside databases

Previous GC identifers: GC00U990451 GC13P020043 GC0XP076516 GC0XP070299


Summaries
for FGF16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF16:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including
embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is
predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a
role in proliferation of embryonic brown adipose tissue. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
differentiation, and is required for normal cardiomyocyte proliferation and heart development




Genomic Views
for FGF16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF16 gene promoter:
         TBP   GATA-3   Tal-1   FOXO3   FOXO3b   Gfi-1   E47   FOXO3a   TGIF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF16 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

FGF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF16 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP076709:  view genomic region     (about GC identifiers)

Start:
 76,709,645 bp from pter      End:
 76,712,769 bp from pter
Size:
 3,125 bases      Orientation:
 plus strand

Proteins
for FGF16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320 (See protein sequence)
Recommended Name: Fibroblast growth factor 16  
Size: 207 amino acids; 23759 Da
Subunit: Interacts with FGFR1 and FGFR2
Subcellular location: Secreted (By similarity)

Explore the universe of human proteins at neXtProt for FGF16: NX_O43320

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43320

    • FGF16 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_003859.1  
    ENSEMBL proteins: 
     ENSP00000399324  
    Reactome Protein details: O43320
    Human Recombinant Protein Products: 
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    Uscn Proteins for FGF16

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9473496


    FGF16 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FGF16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF16 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry O43320

    ProtoNet protein and cluster: O43320

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320
    Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
    differentiation, and is required for normal cardiomyocyte proliferation and heart development

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding ----
    GO:0008083growth factor activity IEA--


    FGF16 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FGF16:
     Lamellipodia cells 

    Animal Models:
         Mouse knock-out Fgf16tm1Nit for FGF16
         11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fgf16):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  hearing/vestibular/ear  mortality/aging  muscle  no phenotypic analysis 
     reproductive system 

    FGF16 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGF16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FGFR2c binds to FGF
    8/14 pathways (see all 14)
    		FGFR2c binds to FGF1.00
    		Signaling by FGFR2 mutants0.76
    		FGFR2c ligand binding and activation1.00
    		Activated point mutants of FGFR20.76
    		FGFR3c ligand binding and activation0.79
    		FGFR4 ligand binding and activation0.73
    		FGFR3 ligand binding and activation0.79
    		FGFR ligand binding and activation0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    3Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FGF16
        Development FGF-family signaling

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF16 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF16
        Development FGF-family signaling

    1 BioSystems Pathway for FGF16 
        Regulation of Actin Cytoskeleton

    5/53        Reactome Pathways for FGF16 (see all 53)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF16):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGF16

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9473496
    GO:0007267cell-cell signaling TAS9473496
    GO:0008152metabolic process TAS9473496
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--


    FGF16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF16
    Search CenterWatch for drugs/clinical trials and news about FGF16 

    Transcripts
    for FGF16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF16 gene: 
    NM_003868.1  

    Unigene Cluster for FGF16:

    Fibroblast growth factor 16
    Hs.666364
    Unigene Representative Sequence: NM_003868
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000439435(uc011mqp.2)

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    Clone
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    Additional cDNA sequence: AB009391.1 

    1 DOTS entry:

    DT.92010031 

    2 AceView cDNA sequences:

    NM_003868 AB009391 

    GeneLoc Exon Structure


    Expression
    for FGF16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCAGAGACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGF16 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeCervical Brown Adipose DepotCervical Committed Brown PreadipocytesAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Committed Brown PreadipocytesAdipose
    AdiposeSacral Brown Adipose DepotSacral Committed Brown PreadipocytesAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Committed Brown PreadipocytesAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Matrigel embedded cells (Derivation of cardio...)

    Genevestigator expression for FGF16

    SOURCE GeneReport for Unigene cluster: Hs.666364
        SABiosciences Custom PCR Arrays for FGF16
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    In Situ
    Assay Products:     
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    Orthologs
    for FGF16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGF16 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGF161 fibroblast growth factor 16 82.13(n)
    90.34(a)    		   422330  NM_001044650.1  NP_001038115.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF166
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343420.1(843947-846255)
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf161 fibroblast growth factor 16 72.91(n)
    80.3(a)    		   692065  NM_001040407.1  NP_001035497.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea let-7566
    		 Protein let-756
    		 10(a)
    		 1 → many
    		 III(6407076-6409965)


    ENSEMBL Gene Tree for FGF16 (if available)
    TreeFam Gene Tree for FGF16 (if available) 

    Paralogs
    for FGF16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF16 gene
    FGF122  FGF52  FGF202  FGF42  FGF92  FGF62  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    18/19 SIMAP similar genes for FGF16 using alignment to 2 protein entries:     FGF16_HUMAN (see all proteins) (see all similar genes):
    FGF9    FGF20    FGF10    FGF7    KGFLP1    KGFLP2
    FGF12    FGF22    PRED3    FGF14    FGF3    fgf gene
    FGF1    FGF11    FGF13    FGF5    FGF6    FGF2

    FGF16 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF16
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF16

    Disorders / Diseases
    for FGF16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF16 for disorders           About GeneDecksing

    OMIM gene information: 300827    OMIM disorders: --

    4 diseases for FGF16:    About MalaCards
    melanoma    breast cancer    adenocarcinoma    pancreatitis


    Export disorders for FGF16 gene to outside databases

    Publications
    for FGF16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF16 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with FGF16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. (PubMed id 9473496)1, 2, 3 Miyake A.... Itoh N. (1998)
    2. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (2006)
    3. The human FGF gene family: chromosome location and phylogenetic analysis. (PubMed id 11474196)1, 3 Kim H.S. (2001)
    4. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PubMed id 16756958)1, 9 Antoine M....Kiefer P. (2006)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart. (PubMed id 20097674)1 Sofronescu A.G....Cattini P.A. (2010)
    7. Fibroblast growth factor signalling: from development to cancer. (PubMed id 20094046)2 Turner N. and Grose R. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. (PubMed id 17133345)1 Moffa A.B. and Ethier S.P. (2007)
    10. Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PubMed id 15199049)1 Popovici C....Roubin R. (2004)

    External Searches for FGF16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing FGF16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8823 HGNC: 3672 AceView: FGF16 Ensembl:ENSG00000196468 euGenes: HUgn8823
    ECgene: FGF16 Kegg: 8823 H-InvDB: FGF16

    Other Databases showing FGF16 gene

    (According to HUGE)
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    Specialized Databases showing FGF16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF16 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FGF16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF16 gene:
    Search GeneIP for patents involving FGF16

    GeneCards and IP:
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