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FGF16 Gene(Protein Coding)

Fibroblast Growth Factor 16

GCID:
GC0XP077447
GIFtS:
55
Genes Participants
UDN Logo

Aliases for FGF16 Gene

Aliases for FGF16 Gene

  • Fibroblast Growth Factor 16 2 3 5
  • Metacarpal 4-5 Fusion 2 3
  • FGF-16 3 4
  • MF4 3

External Ids for FGF16 Gene

Previous HGNC Symbols for FGF16 Gene

  • MF4

Previous GeneCards Identifiers for FGF16 Gene

  • GC00U990451
  • GC13P020043
  • GC0XP076516
  • GC0XP076709
  • GC0XP070299

Summaries for FGF16 Gene

Entrez Gene Summary for FGF16 Gene

  • This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]

GeneCards Summary for FGF16 Gene

FGF16 (Fibroblast Growth Factor 16) is a Protein Coding gene. Diseases associated with FGF16 include Metacarpal 4-5 Fusion and Scotoma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF9.

UniProtKB/Swiss-Prot for FGF16 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF16 Gene

Genomics for FGF16 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FGF16 Gene

Enhancers for FGF16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG077493 0.8 Ensembl ENCODE 13.3 +47.0 46978 0.9 OSR2 MAZ GLIS2 SMARCA4 ZNF341 ZIC2 TRIM28 FGF16 GC0XP077687
GH0XG077527 0.7 ENCODE 12 +80.4 80390 1.2 NFRKB TAL1 CEBPG TCF12 NCOR1 KDM4B RNF2 L3MBTL2 NR4A1 CEBPB FGF16 MAGT1 GC0XP077687
GH0XG078102 1.1 ENCODE 5.4 +657.7 657650 4.6 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 TAF9B CYSLTR1 FGF16 GC0XP078105 GC0XP078104 GC0XM078132 GC0XM078131 GC0XM078130
GH0XG077422 0.4 ENCODE 13.3 -24.3 -24292 2.0 ZNF585B ZBTB7B FGF16 TAF9B SPRYD7P1
GH0XG078325 0.6 ENCODE 5.2 +881.0 881025 5.8 NR2F1 ZNF10 JUNB EBF1 ZNF507 CBX5 IKZF1 CHD2 TAF9B CYSLTR1 FGF16 HMGN1P34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF16 on UCSC Golden Path with GeneCards custom track

Promoters for FGF16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247316 -305 1801

Transcription factor binding sites by QIAGEN in the FGF16 gene promoter:

Genomic Location for FGF16 Gene

Chromosome:
X
Start:
77,447,405 bp from pter
End:
77,457,278 bp from pter
Size:
9,874 bases
Orientation:
Plus strand

Genomic View for FGF16 Gene

Genes around FGF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF16 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGF16 Gene

Proteins for FGF16 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FGF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43320-FGF16_HUMAN
    Recommended name:
    Fibroblast growth factor 16
    Protein Accession:
    O43320

    Protein attributes for FGF16 Gene

    Size:
    207 amino acids
    Molecular mass:
    23759 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2.

neXtProt entry for FGF16 Gene

Protein Expression for FGF16 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FGF16 Gene

  • Glycosylation at isoforms=78
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FGF16

No data available for DME Specific Peptides for FGF16 Gene

Domains & Families for FGF16 Gene

Protein Domains for FGF16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FGF16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43320

UniProtKB/Swiss-Prot:

FGF16_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF16: view

No data available for Gene Families for FGF16 Gene

Function for FGF16 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FGF16 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Gene Ontology (GO) - Molecular Function for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity TAS,IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with FGF16: view
genes like me logo Genes that share phenotypes with FGF16: view

Human Phenotype Ontology for FGF16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF16 Gene

MGI Knock Outs for FGF16:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF16

CRISPR Products

miRNA for FGF16 Gene

miRTarBase miRNAs that target FGF16

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF16 Gene

Localization for FGF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF16 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9473496
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with FGF16: view

Pathways & Interactions for FGF16 Gene

SuperPathways for FGF16 Gene

PathCards logo More details on SuperPathways for FGF16
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
.88
Signaling by FGFR3 in disease
.88
Signaling by FGFR3 point mutants in cancer
.88
FRS-mediated FGFR2 signaling
.85
SHC-mediated cascade-FGFR2
.85
Downstream signaling of activated FGFR2
.83
Downstream signaling of activated FGFR4
.81
FRS-mediated FGFR4 signaling
.81
PI-3K cascade-FGFR2
.77
Activated point mutants of FGFR2
.01
FGFR2c ligand binding and activation
.01
FGFR4 ligand binding and activation
.01
FRS-mediated FGFR3 signaling
.01
Phospholipase C-mediated cascade; FGFR2
.01
Phospholipase C-mediated cascade; FGFR3
.01
Phospholipase C-mediated cascade; FGFR4
.01
PI-3K cascade-FGFR3
.01
PI-3K cascade-FGFR4
.01
SHC-mediated cascade-FGFR3
.01
SHC-mediated cascade-FGFR4
.01
3 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
4 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
5 GAB1 signalosome
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
genes like me logo Genes that share pathways with FGF16: view

Gene Ontology (GO) - Biological Process for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001936 NOT regulation of endothelial cell proliferation IDA 16756958
GO:0007165 signal transduction TAS 9473496
GO:0007267 cell-cell signaling TAS 9473496
GO:0008152 metabolic process TAS 9473496
genes like me logo Genes that share ontologies with FGF16: view

No data available for SIGNOR curated interactions for FGF16 Gene

Drugs & Compounds for FGF16 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FGF16 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FGF16 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF16 Gene

No ASD Table

Relevant External Links for FGF16 Gene

GeneLoc Exon Structure for
FGF16
ECgene alternative splicing isoforms for
FGF16

Expression for FGF16 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF16 Gene

mRNA expression in normal human tissues for FGF16 Gene
mRNA expression by BioGPS for FGF16 GenemRNA expression by GTEx for FGF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF16 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.7) and Breast - Mammary Tissue (x4.1).

Protein differential expression in normal tissues from HIPED for FGF16 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF16 Gene



Protein tissue co-expression partners for FGF16 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF16 Gene:

FGF16

SOURCE GeneReport for Unigene cluster for FGF16 Gene:

Hs.666364

Evidence on tissue expression from TISSUES for FGF16 Gene

  • Heart(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF16 Gene

Germ Layers:
  • mesoderm
Systems:
  • skeleton
Organs:
Limb:
  • digit
  • finger
  • hand
  • upper limb
genes like me logo Genes that share expression patterns with FGF16: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FGF16 Gene

Orthologs for FGF16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FGF16 34 35
  • 99.68 (n)
mouse
(Mus musculus)
 Mammalia Fgf16 34 16 35
  • 95.33 (n)
cow
(Bos Taurus)
 Mammalia FGF16 34 35
  • 94.36 (n)
dog
(Canis familiaris)
 Mammalia FGF16 34 35
  • 94.04 (n)
rat
(Rattus norvegicus)
 Mammalia Fgf16 34
  • 94.04 (n)
oppossum
(Monodelphis domestica)
 Mammalia FGF16 35
  • 53 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FGF16 34 35
  • 82.13 (n)
lizard
(Anolis carolinensis)
 Reptilia FGF16 35
  • 93 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fgf16 34
  • 76.9 (n)
zebrafish
(Danio rerio)
 Actinopterygii fgf16 34 35
  • 72.91 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CS-FGF9/16/20 35
  • 15 (a)
 OneToMany
Species where no ortholog for FGF16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF16 Gene

ENSEMBL:
Gene Tree for FGF16 (if available)
TreeFam:
Gene Tree for FGF16 (if available)

Paralogs for FGF16 Gene

Paralogs for FGF16 Gene

(19) SIMAP similar genes for FGF16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF16: view

Variants for FGF16 Gene

Sequence variations from dbSNP and Humsavar for FGF16 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_072396 Metacarpal 4-5 fusion (MF4) [MIM:309630]
rs587777050 Pathogenic 77,456,433(+) CTAAA(C/T)GACAC reference, stop-gained
rs587777051 Pathogenic 77,456,368(+) GGACT(A/C)AGAGA reference, stop-gained
rs606231304 Pathogenic 77,454,175(+) CTAGG(-/GAATCCTGGAGTTTATCAG)GCCTG reference, frameshift-variant
rs1000164355 -- 77,447,818(+) CGTGG(C/T)TCACC reference, synonymous-codon

Relevant External Links for FGF16 Gene

Human Gene Mutation Database (HGMD)
FGF16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for FGF16 Gene

Disorders for FGF16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGF16 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
metacarpal 4-5 fusion
  • metacarpals 4 and 5 fusion
scotoma
  • blind spot area scotoma
- elite association - COSMIC cancer census association via MalaCards
Search FGF16 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF16_HUMAN
  • Metacarpal 4-5 fusion (MF4) [MIM:309630]: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome. {ECO:0000269 PubMed:23709756, ECO:0000269 PubMed:25333065}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF16
genes like me logo Genes that share disorders with FGF16: view

No data available for Genatlas for FGF16 Gene

Publications for FGF16 Gene

  1. Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. (PMID: 23709756) Jamsheer A. … Mundlos S. (J. Med. Genet. 2013) 2 3 4 64
  2. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. (PMID: 9473496) Miyake A. … Itoh N. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PMID: 16597617) Zhang X. … Ornitz D.M. (J. Biol. Chem. 2006) 3 4 64
  4. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PMID: 16756958) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
  5. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. (PMID: 12851399) Miyakawa K. … Imamura T. (J. Biol. Chem. 2003) 3 22 64

Products for FGF16 Gene

Sources for FGF16 Gene

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