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Aliases for FGF16 Gene

Aliases for FGF16 Gene

  • Fibroblast Growth Factor 16 2 3
  • Metacarpal 4-5 Fusion 2 3
  • FGF-16 3 4
  • MF4 3 6

External Ids for FGF16 Gene

Previous HGNC Symbols for FGF16 Gene

  • MF4

Previous GeneCards Identifiers for FGF16 Gene

  • GC00U990451
  • GC13P020043
  • GC0XP076516
  • GC0XP076709
  • GC0XP070299

Summaries for FGF16 Gene

Entrez Gene Summary for FGF16 Gene

  • This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]

GeneCards Summary for FGF16 Gene

FGF16 (Fibroblast Growth Factor 16) is a Protein Coding gene. Diseases associated with FGF16 include metacarpal 4-5 fusion. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF16 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF16 Gene

Genomics for FGF16 Gene

Regulatory Elements for FGF16 Gene

Genomic Location for FGF16 Gene

Start:
77,447,405 bp from pter
End:
77,457,278 bp from pter
Size:
9,874 bases
Orientation:
Plus strand

Genomic View for FGF16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF16 Gene

Proteins for FGF16 Gene

  • Protein details for FGF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43320-FGF16_HUMAN
    Recommended name:
    Fibroblast growth factor 16
    Protein Accession:
    O43320
    Secondary Accessions:

    Protein attributes for FGF16 Gene

    Size:
    207 amino acids
    Molecular mass:
    23759 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2.

neXtProt entry for FGF16 Gene

Proteomics data for FGF16 Gene at MOPED

Post-translational modifications for FGF16 Gene

  • Glycosylation at Asn78
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF16 Gene

Domains for FGF16 Gene

Suggested Antigen Peptide Sequences for FGF16 Gene

Graphical View of Domain Structure for InterPro Entry

O43320

UniProtKB/Swiss-Prot:

FGF16_HUMAN :
  • O43320
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF16: view

No data available for Gene Families for FGF16 Gene

Function for FGF16 Gene

Molecular function for FGF16 Gene

UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Gene Ontology (GO) - Molecular Function for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF16: view
genes like me logo Genes that share phenotypes with FGF16: view

Animal Models for FGF16 Gene

MGI Knock Outs for FGF16:

Animal Model Products

CRISPR Products

miRNA for FGF16 Gene

miRTarBase miRNAs that target FGF16

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF16 Gene

Localization for FGF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF16 Gene COMPARTMENTS Subcellular localization image for FGF16 gene
Compartment Confidence
extracellular 4
cytosol 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9473496
genes like me logo Genes that share ontologies with FGF16: view

Pathways for FGF16 Gene

SuperPathways for FGF16 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF16: view

Interacting Proteins for FGF16 Gene

Gene Ontology (GO) - Biological Process for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001936 NOT regulation of endothelial cell proliferation IDA 16756958
GO:0007165 signal transduction TAS 9473496
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 9473496
GO:0008152 metabolic process TAS 9473496
genes like me logo Genes that share ontologies with FGF16: view

Transcripts for FGF16 Gene

mRNA/cDNA for FGF16 Gene

(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF16

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF16 Gene

No ASD Table

Relevant External Links for FGF16 Gene

GeneLoc Exon Structure for
FGF16
ECgene alternative splicing isoforms for
FGF16

Expression for FGF16 Gene

mRNA expression in normal human tissues for FGF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF16 Gene

This gene is overexpressed in Adipose - Subcutaneous (5.7) and Breast - Mammary Tissue (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGF16 Gene

SOURCE GeneReport for Unigene cluster for FGF16 Gene Hs.666364

genes like me logo Genes that share expressions with FGF16: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FGF16 Gene

Orthologs for FGF16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF16 35
  • 99.68 (n)
  • 100 (a)
FGF16 36
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF16 35
  • 94.36 (n)
  • 99.03 (a)
FGF16 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF16 35
  • 94.04 (n)
  • 97.58 (a)
FGF16 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf16 35
  • 95.33 (n)
  • 99.52 (a)
Fgf16 16
Fgf16 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF16 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf16 35
  • 94.04 (n)
  • 98.55 (a)
chicken
(Gallus gallus)
Aves FGF16 35
  • 82.13 (n)
  • 90.34 (a)
FGF16 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF16 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf16 35
  • 76.9 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf16 35
  • 72.91 (n)
  • 80.3 (a)
fgf16 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 36
  • 15 (a)
OneToMany
Species with no ortholog for FGF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF16 Gene

ENSEMBL:
Gene Tree for FGF16 (if available)
TreeFam:
Gene Tree for FGF16 (if available)

Paralogs for FGF16 Gene

Paralogs for FGF16 Gene

Selected SIMAP similar genes for FGF16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF16: view

Variants for FGF16 Gene

Sequence variations from dbSNP and Humsavar for FGF16 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs28437036 -- 77,454,302(+) TTTTT(G/T)GGTCA intron-variant
rs28447551 -- 77,454,424(+) GGTGG(G/T)CGGAT intron-variant
rs28498257 -- 77,453,748(+) GCTGC(A/G)TGCTC intron-variant
rs28510987 -- 77,449,022(+) CTTCC(C/T)TTCTT intron-variant
rs28513868 -- 77,452,259(+) TAAGC(A/G)GTCCT intron-variant

Relevant External Links for FGF16 Gene

HapMap Linkage Disequilibrium report
FGF16
Human Gene Mutation Database (HGMD)
FGF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FGF16 Gene

Disorders for FGF16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FGF16 Gene including...

Search for FGF16 Gene in MalaCards »

(1) OMIM Diseases for FGF16 Gene (300827)

UniProtKB/Swiss-Prot

FGF16_HUMAN
  • Metacarpal 4-5 fusion (MF4) [MIM:309630]: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome. {ECO:0000269 PubMed:23709756, ECO:0000269 PubMed:25333065}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with FGF16: view

Publications for FGF16 Gene

  1. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. (PMID: 9473496) Miyake A. … Itoh N. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. (PMID: 23709756) Jamsheer A. … Mundlos S. (J. Med. Genet. 2013) 2 3 4
  3. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. (PMID: 12851399) Miyakawa K. … Imamura T. (J. Biol. Chem. 2003) 3 23
  4. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PMID: 16756958) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. The human FGF gene family: chromosome location and phylogenetic analysis. (PMID: 11474196) Kim H.S. (Cytogenet. Cell Genet. 2001) 2 3

Products for FGF16 Gene

Sources for FGF16 Gene

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