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Aliases for FGF16 Gene

Aliases for FGF16 Gene

  • Fibroblast Growth Factor 16 2 3 5
  • Metacarpal 4-5 Fusion 2 3
  • FGF-16 3 4
  • MF4 3

External Ids for FGF16 Gene

Previous HGNC Symbols for FGF16 Gene

  • MF4

Previous GeneCards Identifiers for FGF16 Gene

  • GC00U990451
  • GC13P020043
  • GC0XP076516
  • GC0XP076709
  • GC0XP070299

Summaries for FGF16 Gene

Entrez Gene Summary for FGF16 Gene

  • This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]

GeneCards Summary for FGF16 Gene

FGF16 (Fibroblast Growth Factor 16) is a Protein Coding gene. Diseases associated with FGF16 include metacarpal 4-5 fusion and syndactyly type 8. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF16 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF16 Gene

Genomics for FGF16 Gene

Regulatory Elements for FGF16 Gene

Promoters for FGF16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGF16 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGF16 Gene

Chromosome:
X
Start:
77,447,405 bp from pter
End:
77,457,278 bp from pter
Size:
9,874 bases
Orientation:
Plus strand

Genomic View for FGF16 Gene

Genes around FGF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF16 Gene

Proteins for FGF16 Gene

  • Protein details for FGF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43320-FGF16_HUMAN
    Recommended name:
    Fibroblast growth factor 16
    Protein Accession:
    O43320

    Protein attributes for FGF16 Gene

    Size:
    207 amino acids
    Molecular mass:
    23759 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2.

neXtProt entry for FGF16 Gene

Proteomics data for FGF16 Gene at MOPED

Post-translational modifications for FGF16 Gene

  • Glycosylation at Asn 78
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF16 Gene

Domains & Families for FGF16 Gene

Suggested Antigen Peptide Sequences for FGF16 Gene

Graphical View of Domain Structure for InterPro Entry

O43320

UniProtKB/Swiss-Prot:

FGF16_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF16: view

No data available for Gene Families for FGF16 Gene

Function for FGF16 Gene

Molecular function for FGF16 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Gene Ontology (GO) - Molecular Function for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
genes like me logo Genes that share ontologies with FGF16: view
genes like me logo Genes that share phenotypes with FGF16: view

Human Phenotype Ontology for FGF16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF16 Gene

MGI Knock Outs for FGF16:

Animal Model Products

miRNA for FGF16 Gene

miRTarBase miRNAs that target FGF16

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF16 Gene

Localization for FGF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF16 Gene COMPARTMENTS Subcellular localization image for FGF16 gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FGF16 Gene

Pathways & Interactions for FGF16 Gene

SuperPathways for FGF16 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K events in ERBB4 signaling
4 SHC-mediated cascade-FGFR4
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF16: view

Interacting Proteins for FGF16 Gene

Gene Ontology (GO) - Biological Process for FGF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001936 NOT regulation of endothelial cell proliferation IDA 16756958
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with FGF16: view

No data available for SIGNOR curated interactions for FGF16 Gene

Drugs & Compounds for FGF16 Gene

No Compound Related Data Available

Transcripts for FGF16 Gene

mRNA/cDNA for FGF16 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF16 Gene

No ASD Table

Relevant External Links for FGF16 Gene

GeneLoc Exon Structure for
FGF16
ECgene alternative splicing isoforms for
FGF16

Expression for FGF16 Gene

mRNA expression in normal human tissues for FGF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF16 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.7) and Breast - Mammary Tissue (x4.1).

Protein differential expression in normal tissues from HIPED for FGF16 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF16 Gene



SOURCE GeneReport for Unigene cluster for FGF16 Gene Hs.666364

genes like me logo Genes that share expression patterns with FGF16: view

Protein tissue co-expression partners for FGF16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FGF16 Gene

Orthologs for FGF16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF16 35
  • 94.36 (n)
  • 99.03 (a)
FGF16 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF16 35
  • 94.04 (n)
  • 97.58 (a)
FGF16 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf16 35
  • 95.33 (n)
  • 99.52 (a)
Fgf16 16
Fgf16 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF16 35
  • 99.68 (n)
  • 100 (a)
FGF16 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf16 35
  • 94.04 (n)
  • 98.55 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF16 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF16 35
  • 82.13 (n)
  • 90.34 (a)
FGF16 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF16 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf16 35
  • 76.9 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf16 35
  • 72.91 (n)
  • 80.3 (a)
fgf16 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 36
  • 15 (a)
OneToMany
Species with no ortholog for FGF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF16 Gene

ENSEMBL:
Gene Tree for FGF16 (if available)
TreeFam:
Gene Tree for FGF16 (if available)

Paralogs for FGF16 Gene

Paralogs for FGF16 Gene

(19) SIMAP similar genes for FGF16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF16: view

Variants for FGF16 Gene

Sequence variations from dbSNP and Humsavar for FGF16 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_072396 Metacarpal 4-5 fusion (MF4)
rs28498257 -- 77,453,748(+) GCTGC(A/G)TGCTC intron-variant
rs28510987 -- 77,449,022(+) CTTCC(C/T)TTCTT intron-variant
rs28513868 -- 77,452,259(+) TAAGC(A/G)GTCCT intron-variant
rs28602939 -- 77,452,303(+) TCAAA(C/T)GGAGC intron-variant

Relevant External Links for FGF16 Gene

HapMap Linkage Disequilibrium report
FGF16
Human Gene Mutation Database (HGMD)
FGF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for FGF16 Gene

Disorders for FGF16 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FGF16 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
metacarpal 4-5 fusion
  • metacarpals 4 and 5 fusion
syndactyly type 8
  • fusion of metacarpals 4 and 5
hard palate cancer
  • hard palate
- elite association - COSMIC cancer census association via MalaCards
Search FGF16 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF16_HUMAN
  • Metacarpal 4-5 fusion (MF4) [MIM:309630]: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome. {ECO:0000269 PubMed:23709756, ECO:0000269 PubMed:25333065}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF16
genes like me logo Genes that share disorders with FGF16: view

No data available for Genatlas for FGF16 Gene

Publications for FGF16 Gene

  1. Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. (PMID: 23709756) Jamsheer A. … Mundlos S. (J. Med. Genet. 2013) 2 3 4 67
  2. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PMID: 16756958) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. (PMID: 12851399) Miyakawa K. … Imamura T. (J. Biol. Chem. 2003) 3 23
  4. The human FGF gene family: chromosome location and phylogenetic analysis. (PMID: 11474196) Kim H.S. (Cytogenet. Cell Genet. 2001) 2 3
  5. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. (PMID: 9473496) Miyake A. … Itoh N. (Biochem. Biophys. Res. Commun. 1998) 2 3

Products for FGF16 Gene

Sources for FGF16 Gene

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