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FGF16 Gene

protein-coding   GIFtS: 52
GCID: GC0XP076709

Fibroblast Growth Factor 16

(Previous name: metacarpal 4-5 fusion)
(Previous symbol: MF4)
  See FGF16-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 161 2
MF41 2 5
Metacarpal 4-5 Fusion1 2
FGF-162 3

External Ids:    HGNC: 36721   Entrez Gene: 88232   Ensembl: ENSG000001964687   OMIM: 3008275   UniProtKB: O433203   

Export aliases for FGF16 gene to outside databases

Previous GC identifers: GC00U990451 GC13P020043 GC0XP076516 GC0XP070299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF16 Gene:
This gene encodes a member of a family of proteins that are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also
observed in individuals with metacarpal 4-5 fusion. (provided by RefSeq, Mar 2014)

GeneCards Summary for FGF16 Gene:
FGF16 (fibroblast growth factor 16) is a protein-coding gene. Diseases associated with FGF16 include metacarpals 4 and 5 fusion. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
differentiation, and is required for normal cardiomyocyte proliferation and heart development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FGF16 gene promoter:
         TBP   GATA-3   Tal-1   FOXO3   FOXO3b   Gfi-1   E47   FOXO3a   TGIF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF16 promoter sequence
   Search Chromatin IP Primers for FGF16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

FGF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF16 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP076709:  view genomic region     (about GC identifiers)

Start:
76,709,645 bp from pter      End:
76,712,769 bp from pter
Size:
3,125 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320 (See protein sequence)
Recommended Name: Fibroblast growth factor 16  
Size: 207 amino acids; 23759 Da
Subunit: Interacts with FGFR1 and FGFR2

Explore the universe of human proteins at neXtProt for FGF16: NX_O43320

Explore proteomics data for FGF16 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn78
  • Modification sites at PhosphoSitePlus

  • See FGF16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003859.1  
    ENSEMBL proteins: 
     ENSP00000399324  
    Reactome Protein details: O43320

    FGF16 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for FGF16
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    Search eBioscience for ELISAs for FGF16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028285 FGF16
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry O43320

    ProtoNet protein and cluster: O43320

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF16_HUMAN, O43320
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF16_HUMAN, O43320
    Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
    differentiation, and is required for normal cardiomyocyte proliferation and heart development

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with FGF16           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF16:
     Lamellipodia cells 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fgf16):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  hearing/vestibular/ear  mortality/aging  muscle  no phenotypic analysis 
     reproductive system 

    Find genes that share phenotypes with FGF16           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fgf16tm1Nit for FGF16

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF16

    miRNA
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    hsa-mir-335-5p (MIRT016941)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF16_HUMAN, O43320: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9473496

    Find genes that share ontologies with FGF16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF16 About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    Development FGF family signaling0.43
    SHC-mediated cascade0.79
    FGFR4 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with FGF16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF16 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF16
        Development FGF-family signaling

    1 BioSystems Pathway for FGF16
        Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF16 (see all 15)
        Signaling by FGFR mutants
    PI3K Cascade
    FGFR2c ligand binding and activation
    Phospholipase C-mediated cascade
    FRS2-mediated cascade


    Selected Kegg Pathways  (Kegg details for FGF16) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGF16
    Interactions:

        Search GeneGlobe Interaction Network for FGF16

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9473496
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS9473496
    GO:0008152metabolic process TAS9473496
    GO:0008286insulin receptor signaling pathway TAS--

    Find genes that share ontologies with FGF16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF16 gene: 
    NM_003868.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000439435(uc011mqp.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat FGF16

    2 AceView cDNA sequences:

    NM_003868 AB009391 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGAGACC
    FGF16 Expression
    About this image


    FGF16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Lumbar Committed Brown Preadipocytes Lumbar Brown Adipose Depot
     
     Heart (Cardiovascular System)
    FGF16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF16 Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF16 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf161 , 5 fibroblast growth factor 161, 5 95.33(n)1
    99.52(a)1
      X (47.20 cM)5
    809031  NM_030614.21  NP_085117.21 
     1057642795 
    chicken
    (Gallus gallus)
    Aves FGF161 fibroblast growth factor 16 82.13(n)
    90.34(a)
      422330  NM_001044650.1  NP_001038115.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF166
    fibroblast growth factor 16
    93(a)
    1 ↔ 1
    GL343420.1(843947-846255)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgf161 fibroblast growth factor 16 76.9(n)
    88.12(a)
      100492309  XM_002931813.2  XP_002931859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf161 fibroblast growth factor 16 72.91(n)
    80.3(a)
      692065  NM_001040407.1  NP_001035497.1 


    ENSEMBL Gene Tree for FGF16 (if available)
    TreeFam Gene Tree for FGF16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF16 gene
    FGF122  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    Selected SIMAP similar genes for FGF16 using alignment to 2 protein entries:     FGF16_HUMAN (see all proteins) (see all similar genes):
    FGF9    FGF20    FGF10    FGF7    KGFLP1    KGFLP2
    FGF12    FGF22    PRED3    FGF14    FGF3    fgf gene
    FGF1    FGF11    FGF13    FGF5    FGF6    FGF2

    Find genes that share paralogs with FGF16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF16 (see all 80)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512490281,2
    --76677526(+) CTCTCA/GCCTAG 1 -- int10--------
    rs1828317791,2
    --76677819(+) TTTGCC/GGGAAA 1 -- int10--------
    rs1865708001,2
    --76678071(+) CTCCTC/TGGTAA 1 -- int10--------
    rs1910789311,2
    --76678246(+) CTACAC/TTCAGA 1 -- int10--------
    rs285109871,2
    C--76678266(+) CTTCCC/TTTCTT 1 -- int1 tfbs3 trp30--------
    rs1832286811,2
    --76678342(+) CCATGA/CCTTGC 1 -- int10--------
    rs1876000031,2
    --76678752(+) ACTCAC/TTGCCG 1 -- int10--------
    rs1930432301,2
    --76678756(+) ATTGCC/TGATAT 1 -- int10--------
    rs1831405061,2
    --76679001(+) TAAGGA/GTGTTA 1 -- int10--------
    rs2021686311,2
    --76679020(+) AGAAA-/CTT   
       AACAC
    CCAAA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for FGF16 (76709645 - 76712769 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FGF16: --
    Human Gene Mutation Database (HGMD): FGF16
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FGF16
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300827   
    OMIM disorders: 309630  
    1 disease for FGF16:    
    About MalaCards
    metacarpals 4 and 5 fusion


    Find genes that share disorders with FGF16           About GenesLikeMe


    Export disorders for FGF16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF16 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FGF16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. (PubMed id 9473496)1, 2, 3 Miyake A.... Itoh N. (Biochem. Biophys. Res. Commun. 1998)
    2. Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. (PubMed id 23709756)1, 3 Jamsheer A....Mundlos S. (J. Med. Genet. 2013)
    3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (J. Biol. Chem. 2006)
    4. The human FGF gene family: chromosome location and phylogenetic analysis. (PubMed id 11474196)1, 3 Kim H.S. (Cytogenet. Cell Genet. 2001)
    5. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. (PubMed id 16756958)1, 9 Antoine M....Kiefer P. (Biochem. Biophys. Res. Commun. 2006)
    6. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. (PubMed id 12851399)1, 9 Miyakawa K. and Imamura T. (J. Biol. Chem. 2003)
    7. FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway. (PubMed id 24253043)1 Basu M....Roy S.S. (J. Biol. Chem. 2014)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart. (PubMed id 20097674)1 Sofronescu A.G....Cattini P.A. (Cardiovasc. Res. 2010)
    10. Fibroblast growth factor signalling: from development to cancer. (PubMed id 20094046)2 Turner N. and Grose R. (Nat. Rev. Cancer 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8823 HGNC: 3672 AceView: FGF16 Ensembl:ENSG00000196468 euGenes: HUgn8823
    ECgene: FGF16 Kegg: 8823 H-InvDB: FGF16

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF16 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF16 gene:
    Search GeneIP for patents involving FGF16

    GeneCards and IP:
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