Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FGF14 Gene

protein-coding   GIFtS: 58
GCID: GC13M102373

Fibroblast Growth Factor 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fibroblast Growth Factor 141 2     FHF-42 3
FHF42 3 5     SCA272 5
Fibroblast Growth Factor Homologous Factor 42 3     bA397O8.22
FGF-142 3     

External Ids:    HGNC: 36711   Entrez Gene: 22592   Ensembl: ENSG000001024667   OMIM: 6015155   UniProtKB: Q929153   

Export aliases for FGF14 gene to outside databases

Previous GC identifers: GC13M100735 GC13M096762 GC13M101211 GC13M100073 GC13M101173 GC13M082966


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FGF14 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation
in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF14 Gene:
FGF14 (fibroblast growth factor 14) is a protein-coding gene. Diseases associated with FGF14 include spinocerebellar ataxia 27, and spinocerebellar ataxia type27. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF14_HUMAN, Q92915
Function: Probably involved in nervous system development and function

Gene Wiki entry for FGF14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF14 gene promoter:
         TBP   NRSF form 1   TFIID   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FGF14 promoter sequence
   Search Chromatin IP Primers for FGF14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q33.1   HGNC cytogenetic band: 13q34

FGF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF14 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M102373:  view genomic region     (about GC identifiers)

Start:
102,372,134 bp from pter      End:
103,054,124 bp from pter
Size:
681,991 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FGF14_HUMAN, Q92915 (See protein sequence)
Recommended Name: Fibroblast growth factor 14  
Size: 247 amino acids; 27702 Da
Secondary accessions: Q86YN7 Q96QX6
Alternative splicing: 2 isoforms:  Q92915-1   Q92915-2   (Variant in position: 44:W->C (in a colorectal cancer sample))

Explore the universe of human proteins at neXtProt for FGF14: NX_Q92915

Explore proteomics data for FGF14 at MOPED


See FGF14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_004106.1  NP_787125.1  

ENSEMBL proteins: 
 ENSP00000365301   ENSP00000365313  

FGF14 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for FGF14
OriGene Protein Over-expression Lysate for FGF14
OriGene MassSpec for FGF14
OriGene Custom Protein Services for FGF14
GenScript Custom Purified and Recombinant Proteins Services for FGF14
Novus Biologicals FGF14 Proteins
Novus Biologicals FGF14 Lysates
Sino Biological Recombinant Protein for FGF14
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for FGF14
Cloud-Clone Corp. Proteins for FGF14

FGF14 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for FGF14
OriGene Custom Antibody Services for FGF14
Novus Biologicals FGF14 Antibodies
Abcam antibodies for FGF14
Cloud-Clone Corp. Antibodies for FGF14
Search ThermoFisher Antibodies for FGF14
LSBio Antibodies in human, mouse, rat for FGF14

FGF14 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FGF14
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for FGF14
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FGF14
Cloud-Clone Corp. CLIAs for FGF14


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
4 InterPro protein domains:
 IPR028142 IL-1_fam/FGF_fam
 IPR028284 FGF14
 IPR008996 Cytokine_IL1-like
 IPR002209 Fibroblast_GF_fam

Graphical View of Domain Structure for InterPro Entry Q92915

ProtoNet protein and cluster: Q92915

2 Blocks protein domains:
IPB002209 Heparin binding growth factor family signature
IPB002348 IL1/HBGF family signature


UniProtKB/Swiss-Prot: FGF14_HUMAN, Q92915
Similarity: Belongs to the heparin-binding growth factors family


FGF14 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FGF14_HUMAN, Q92915
Function: Probably involved in nervous system development and function

     Genatlas biochemistry entry for FGF14:
fibroblast growth homologous factor 14,expressed principally in the nervous system

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005104NOT fibroblast growth factor receptor binding IDA12815063
GO:0008083growth factor activity IEA--
GO:0008201heparin binding IDA12815063
     
FGF14 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf14):
 behavior/neurological  growth/size/body  nervous system 

FGF14 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF14
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF14

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF14
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF14

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat FGF14 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FGF14 (see all 71):
hsa-miR-100* hsa-miR-3938 hsa-miR-128 hsa-miR-3916 hsa-miR-761 hsa-miR-130a* hsa-miR-27a hsa-miR-23c
SwitchGear 3'UTR luciferase reporter plasmidFGF14 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for FGF14
Predesigned siRNA for gene silencing in human, mouse, rat FGF14

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for FGF14

Clone
Products:
     
OriGene clones in human, mouse for FGF14 (see all 13)
OriGene ORF clones in mouse, rat for FGF14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): FGF14 (NM_175929)
Sino Biological Human cDNA Clone for FGF14
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF14
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF14

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for FGF14
Browse ESI BIO Cell Lines and PureStem Progenitors for FGF14 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF14


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
FGF14_HUMAN, Q92915: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2
extracellular2
endoplasmic reticulum1
mitochondrion1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005634nucleus IEA--

FGF14 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for FGF14 About   (see all 21)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Regulation of actin cytoskeleton
Regulation of actin cytoskeleton0.57
Regulation of Actin Cytoskeleton0.57
2Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
3GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
P2Y Receptor Signaling0.38
4TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
5ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF14 (see all 59)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

1 BioSystems Pathway for FGF14
    Regulation of Actin Cytoskeleton



Selected Kegg Pathways  (Kegg details for FGF14) (see all 8):
    MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton


FGF14 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including FGF14: 
          Growth Factors in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for FGF14

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for FGF14 (ENSP000003653014) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
EGFRENSP000002754934STRING: ENSP00000275493
FGFR1ENSP000003802804STRING: ENSP00000380280
FGFR2ENSP000004102944STRING: ENSP00000410294
FGFR3ENSP000002607954STRING: ENSP00000260795
FGFR4ENSP000002924084STRING: ENSP00000292408
About this table

Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction TAS8790420
GO:0007254JNK cascade IPI12815063
GO:0007267cell-cell signaling TAS8790420
GO:0007268synaptic transmission IEA--
GO:0007399nervous system development IEA--

FGF14 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FGF14

1 Novoseek inferred chemical compound relationship for FGF14 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rantes 45.8 1 15140220 (1)



FGF14 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for FGF14 gene (2 alternative transcripts): 
NM_004115.3  NM_175929.2  

Unigene Cluster for FGF14:

Fibroblast growth factor 14
Hs.508616  [show with all ESTs]
Unigene Representative Sequence: NM_175929
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000376131(uc001vpf.2) ENST00000376143(uc001vpe.2) ENST00000468052

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat FGF14 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FGF14 (see all 71):
hsa-miR-100* hsa-miR-3938 hsa-miR-128 hsa-miR-3916 hsa-miR-761 hsa-miR-130a* hsa-miR-27a hsa-miR-23c
SwitchGear 3'UTR luciferase reporter plasmidFGF14 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FGF14
Predesigned siRNA for gene silencing in human, mouse, rat FGF14
Clone
Products:
     
OriGene clones in human, mouse for FGF14 (see all 13)
OriGene ORF clones in mouse, rat for FGF14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): FGF14 (NM_175929)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF14
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF14
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FGF14
OriGene qSTAR qPCR primer pairs in human, mouse for FGF14
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF14
  QuantiTect SYBR Green Assays in human, mouse, rat FGF14
  QuantiFast Probe-based Assays in human, mouse, rat FGF14

Additional mRNA sequence: 

AY188178.1 BC100920.1 BC100921.1 BC100922.2 U66200.1 

5 DOTS entries:

DT.40215907  DT.100737455  DT.209580  DT.40207510  DT.91792440 

Selected AceView cDNA sequences (see all 81):

AA988788 AI630825 BE221932 U66200 AW449524 BQ129273 AA973525 BQ448638 
AW341130 AW139662 CR616826 AI801969 AI914111 NM_004115 BE549662 C21321 
AI215185 BE326455 AI694924 BE673664 BE221074 BF223371 BE327564 AA336326 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FGF14    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1:        -     -     -     -     -     -     -     -     -                       -               
SP2:                    -     -           -                                                         
SP3:                                                                                                
SP4:                                      -                                                         
SP5:                                                                                                


ECgene alternative splicing isoforms for FGF14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

FGF14 expression in normal human tissues (normalized intensities)      FGF14 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACAGCCCTTG
FGF14 Expression
About this image


FGF14 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Brain (Nervous System)    fully expand to see all 6 entries
         Oligodendrocyte Precursor Cells Forebrain White Matter
         Thalamus
 
 Eye (Sensory Organs)    fully expand to see all 4 entries
         Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
         Lens
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Telencephalon
 
 Neurons
         GABAergic Amacrine Cells Inner Nuclear Layer
 
 Lung (Respiratory System)
         Trachea
FGF14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FGF14 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.508616

UniProtKB/Swiss-Prot: FGF14_HUMAN, Q92915
Tissue specificity: Nervous system

    Pathway & Disease-focused RT2 Profiler PCR Array including FGF14: 
          Growth Factors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for FGF14
OriGene qSTAR qPCR primer pairs in human, mouse for FGF14
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF14
QuantiTect SYBR Green Assays in human, mouse, rat FGF14
QuantiFast Probe-based Assays in human, mouse, rat FGF14
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF14

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for FGF14 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fgf141 , 5 fibroblast growth factor 141, 5 95.01(n)1
98.79(a)1
  14 (66.18 cM)5
141691  NM_010201.41  NP_034331.21 
 1239779075 
chicken
(Gallus gallus)
Aves FGF146
fibroblast growth factor 14
76(a)
1 ↔ 1
1(142471032-142606517)
lizard
(Anolis carolinensis)
Reptilia FGF146
fibroblast growth factor 14
77(a)
1 ↔ 1
3(100435670-100574569)
African clawed frog
(Xenopus laevis)
Amphibia Xl.327352 Xenopus laevis transcribed sequence with moderate similarity more 89.29(n)    AW644782.1 
zebrafish
(Danio rerio)
Actinopterygii fgf141 fibroblast growth factor 14 80.85(n)
91.32(a)
  497642  NM_001012382.1  NP_001012382.1 


ENSEMBL Gene Tree for FGF14 (if available)
TreeFam Gene Tree for FGF14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for FGF14 gene
FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
FGF72  FGF112  FGF102  FGF132  FGF222  
12 SIMAP similar genes for FGF14 using alignment to 1 protein entry:     FGF14_HUMAN:
FGF12    FGF13    FGF11    FGF16    FGF20    FGF9
FGF10    FGF5    FGF6    FGF1    FGF4    FGF2

FGF14 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for FGF14 (see all 13856)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0227364
Spinocerebellar ataxia 27 (SCA27)4--see VAR_0227362 F S mis40--------
rs1048943931,2
Cpathogenic183305156(-) CAAGTC/TTAAAG 4 S F mis10--------
rs680564661,2
C--82974439(+) CTTTT-/ATACTG 2 -- int10--------
rs2007879381,2
--82980414(+) TTAAC-/AATAATAA 2 -- int10--------
rs352646421,2
C--82983221(+) AAAAAT/ATGAAG 2 -- int11Minor allele frequency- A:0.50NA 2
rs718564171,2
C--82984735(+) GTGTG-/TATA  
        
TATAT
2 -- int10--------
rs1997548061,2
C--82984735(+) GTGTG-/TATATAT 2 -- int10--------
rs14104771,2
C,F,A,H--82984736(-) ATATAC/TACACA 2 -- int13Minor allele frequency- T:0.33NA 6
rs768911461,2
C--82984738(+) TGTATG/ATATAT 2 -- int11Minor allele frequency- A:0.50WA 2
rs605949911,2
C--82984750(+) TATATAT/-GCCAA 2 -- int11Minor allele frequency- -:0.50NA 2

HapMap Linkage Disequilibrium report for FGF14 (102372134 - 102622134 bp, first 250kb of FGF14)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FGF14 (see all 39):    About this table    
Variant IDTypeSubtypePubMed ID
esv2747902CNV Deletion23290073
esv2098077CNV Deletion18987734
esv2747904CNV Deletion23290073
esv2665206CNV Deletion23128226
esv2662927CNV Deletion23128226
esv2747908CNV Deletion23290073
esv1010266CNV Deletion20482838
esv2747903CNV Deletion23290073
esv2546035CNV Deletion19546169
esv3231CNV Deletion18987735

Human Gene Mutation Database (HGMD): FGF14
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FGF14
DNA2.0 Custom Variant and Variant Library Synthesis for FGF14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 601515   
OMIM disorders: 609307  
UniProtKB/Swiss-Prot: FGF14_HUMAN, Q92915
  • Spinocerebellar ataxia 27 (SCA27) [MIM:609307]: Spinocerebellar ataxia is a clinically and genetically
    heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor
    coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement
    of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly
    progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor,
    orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for FGF14 (see all 29):    About MalaCards
    spinocerebellar ataxia 27    spinocerebellar ataxia type27    paroxysmal dyskinesia    ladd syndrome
    ataxia    cerebritis    spinocerebellar ataxia    tremor
    cerebellar ataxia    venous thrombosis    multiple sclerosis    pre-eclampsia
    eclampsia    hyperglycemia    gingivitis    breast and colorectal cancer
    retinitis    hypoxia    schizophrenia    obesity

    2 diseases from the University of Copenhagen DISEASES database for FGF14:
    Spinocerebellar ataxia     LADD syndrome

    FGF14 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for FGF14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sca17 79.3 6 15148151 (1), 15895552 (1)
    spinocerebellar ataxias 77.5 4 16211615 (1), 18930825 (1)
    drpla 63.5 6 15148151 (1), 15895552 (1)
    necrosis 55.4 12 17917114 (1), 19349318 (1), 19344712 (1), 17018610 (1) (see all 9)
    tumors 40.8 12 17917114 (1), 19349318 (1), 19344712 (1), 17018610 (1) (see all 8)
    multiple sclerosis 28.7 1 19018248 (1)
    glioma 12.6 5 17018610 (2), 15611130 (1)

    Genetic Association Database (GAD): FGF14
    Human Genome Epidemiology (HuGE) Navigator: FGF14 (3 documents)

    Export disorders for FGF14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FGF14 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with FGF14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias. (PubMed id 15470364)1, 2, 4, 9 Dalski A....Zuehlke C. (Eur. J. Hum. Genet. 2005)
    2. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14. (PubMed id 17236779)1, 3, 9 Wozniak D.F....Ornitz D.M. (Neurobiol. Dis. 2007)
    4. Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. (PubMed id 15148151)1, 4, 9 Brusco A....Taroni F. (Arch. Neurol. 2004)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    7. A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar (sic) ataxia. (PubMed id 12489043)1, 2 van Swieten J.C.... Heutink P. (Am. J. Hum. Genet. 2003)
    8. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)1, 2 Chumakov I.... Cohen D. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype. (PubMed id 16211615)1, 9 Brusse E....van Swieten J.C. (Mov. Disord. 2006)
    10. The fibroblast growth factor 14A^voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3). (PubMed id 23640885)1 Shavkunov A.S....Laezza F. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2259 HGNC: 3671 AceView: FGF14 Ensembl:ENSG00000102466 euGenes: HUgn2259
    ECgene: FGF14 Kegg: 2259 H-InvDB: FGF14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FGF14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF14 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FGF14[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FGF14 gene:
    Search GeneIP for patents involving FGF14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FGF14   OriGene RNAi products in human, mouse, rat for FGF14  
     OriGene qPCR primer pairs and template standards for FGF14   OriGene Protein Over-expression Lysate for FGF14  
     OriGene MassSpec something-or-other for FGF14   OriGene clones in human, mouse for FGF14  
     OriGene qSTAR qPCR primer pairs in human, mouse for FGF14   OriGene Purified Protein for FGF14  
     OriGene ORF clones in mouse, rat for FGF14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FGF14   OriGene Custom Protein Services for FGF14  

     
     
     Block miRNA regulation of human, mouse, rat FGF14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FGF14
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF14 Predesigned siRNA for gene silencing in human, mouse, rat FGF14
     QuantiFast Probe-based Assays in human, mouse, rat FGF14 QuantiTect SYBR Green Assays in human, mouse, rat FGF14
     PCR Arrays including human, mouse, rat FGF14 Search Chromatin IP Primers for FGF14
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF14  Search GeneGlobe Interaction Network for FGF14
     Regulatory tfbs in FGF14 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FGF14 GenScript cDNA clones with any tag delivered in your preferred vector for FGF14
     GenScript Custom Assay Services for FGF14 GenScript Custom overexpressing Cell Line Services for FGF14
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FGF14
     Proteins for FGF14
     Browse Sino Biological Cell Lysates
     cDNA Clones for FGF14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FGF14 antibodies
     FGF14 proteins
     FGF14 lysates
     Antibodies for FGF14
     See all of Abcam's Antibodies, Kits and Proteins for FGF14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FGF14
     Proteins for FGF14
     Antibodies for FGF14
     ELISAs for FGF14
     CLIAs for FGF14



     Browse ESI BIO Cell Lines and PureStem Progenitors for FGF14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF14
     SwitchGear 3'UTR luciferase reporter plasmids for FGF14
     SwitchGear Promoter luciferase reporter plasmids for FGF14
     Search ThermoFisher Antibodies for FGF14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF14
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF14
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF14
     LSBio Antibodies in human, mouse, rat for FGF14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FGF14 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4