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FGF13 Gene

protein-coding   GIFtS: 63
GCID: GC0XM137713

Fibroblast Growth Factor 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 131 2
Fibroblast Growth Factor Homologous Factor 21 2 3
FGF-132 3
FHF-22 3
FHF22 3
FGF22 5

External Ids:    HGNC: 36701   Entrez Gene: 22582   Ensembl: ENSG000001296827   OMIM: 3000705   UniProtKB: Q929133   

Export aliases for FGF13 gene to outside databases

Previous GC identifers: GC0XM132285 GC0XM134559 GC0XM135658 GC0XM136419 GC0XM137439 GC0XM137541 GC0XM126980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF13 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene
is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS),
making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms
of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in
several transcript variants encoding different isoforms with different N-termini. (provided by RefSeq, Nov 2008)

GeneCards Summary for FGF13 Gene:
FGF13 (fibroblast growth factor 13) is a protein-coding gene. Diseases associated with FGF13 include borjeson-forssman-lehmann syndrome, and hypertrichosis. GO annotations related to this gene include growth factor activity and ion channel binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and
stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by
negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and
migration in the cerebral cortex and the hippocampus
Function: May regulate voltage-gated sodium channels transport and function
Function: May also play a role in MAPK signaling

Gene Wiki entry for FGF13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF13 gene promoter:
         GR   SRY   GR-beta   FOXO4   Nkx3-1 v3   GR-alpha   CUTL1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FGF13 promoter sequence
   Search Chromatin IP Primers for FGF13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq27.1   HGNC cytogenetic band: Xq26.3

FGF13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF13 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM137713:  view genomic region     (about GC identifiers)

Start:
137,713,734 bp from pter      End:
138,304,939 bp from pter
Size:
591,206 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913 (See protein sequence)
Recommended Name: Fibroblast growth factor 13  
Size: 245 amino acids; 27564 Da
Subunit: Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity.
Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May
also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity
2 PDB 3D structures from and Proteopedia for FGF13:
3HBW (3D)        4DCK (3D)    
Secondary accessions: B1AK18 B7Z4M7 B7Z8N0 D3DWH4 O95830 Q9NZH9 Q9NZI0
Alternative splicing: 5 isoforms:  Q92913-1   Q92913-2   Q92913-3   Q92913-4   Q92913-5   

Explore the universe of human proteins at neXtProt for FGF13: NX_Q92913

Explore proteomics data for FGF13 at MOPED

Post-translational modifications: 

  • May be phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001132970.1  NP_001132972.1  NP_001132973.1  NP_001132974.1  NP_004105.1  NP_378668.1  

    ENSEMBL proteins: 
     ENSP00000322390   ENSP00000303391   ENSP00000396198   ENSP00000406916   ENSP00000411999  
     ENSP00000388688   ENSP00000359635   ENSP00000437903   ENSP00000409276  

    FGF13 Human Recombinant Protein Products:

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    Novus Biologicals FGF13 Protein
    Novus Biologicals FGF13 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FGF13
    Cloud-Clone Corp. Proteins for FGF13

    FGF13 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FGF13
    R&D Systems Antibodies for FGF13 (FGF-13)
    OriGene Antibodies for FGF13
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    Novus Biologicals FGF13 Antibodies
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    FGF13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for FGF13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF13
    Cloud-Clone Corp. CLIAs for FGF13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028279 FGF13

    Graphical View of Domain Structure for InterPro Entry Q92913

    ProtoNet protein and cluster: Q92913

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Similarity: Belongs to the heparin-binding growth factors family


    FGF13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF13_HUMAN, Q92913
    Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and
    stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by
    negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and
    migration in the cerebral cortex and the hippocampus
    Function: May regulate voltage-gated sodium channels transport and function
    Function: May also play a role in MAPK signaling

         Genatlas biochemistry entry for FGF13:
    fibroblast growth homologous factor 13,expressed principally in the nervous system and skeletal muscle with two
    alternatively spliced isoforms

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15282281
    GO:0008017microtubule binding ISS--
    GO:0008083growth factor activity IEA--
    GO:0017080sodium channel regulator activity IDA15282281
    GO:0030295protein kinase activator activity IGI12244047
         
    FGF13 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf13):
     behavior/neurological  cellular  nervous system 

    FGF13 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF13

    miRNA
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    miRTarBase miRNAs that target FGF13:
    hsa-mir-155-5p (MIRT020683), hsa-mir-32-5p (MIRT028310), hsa-mir-186-5p (MIRT021161), hsa-mir-192-5p (MIRT026446), hsa-mir-92a-3p (MIRT049684), hsa-mir-103a-3p (MIRT027141), hsa-mir-503-5p (MIRT007223), hsa-mir-140-5p (MIRT003962), hsa-mir-215-5p (MIRT024732), hsa-mir-16-5p (MIRT001468)

    Block miRNA regulation of human, mouse, rat FGF13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF13 (see all 17):
    hsa-miR-539 hsa-miR-4272 hsa-miR-3692 hsa-miR-570 hsa-miR-421 hsa-miR-511 hsa-miR-641 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidFGF13 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FGF13
    Predesigned siRNA for gene silencing in human, mouse, rat FGF13

    Gene Editing
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    OriGene ORF clones in mouse, rat for FGF13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): FGF13 (NM_004114)
    Sino Biological Human cDNA Clone for FGF13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF13

    Cell Line
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    ESI BIO PureStem Progenitor for FGF13: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF13_HUMAN, Q92913: Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity).
    Cell projection, dendrite (By similarity). Nucleus. Cytoplasm. Note=Not secreted (By similarity)
    FGF13_HUMAN, Q92913: Isoform 1: Nucleus, nucleolus
    FGF13_HUMAN, Q92913: Isoform 2: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    plasma membrane4
    cytosol2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005634nucleus IDA8790420
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IPI12244047
    GO:0005874microtubule ISS--

    FGF13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF13 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF13 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF13
        Regulation of Actin Cytoskeleton



    Selected Kegg Pathways  (Kegg details for FGF13) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton


    FGF13 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF13: 
              Parkinson's Disease in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for FGF13 (Q929133 ENSP000003223904) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133873, ENSP000003305724I2D: score=1 STRING: ENSP00000330572
    SCN8AQ9UQD03, ENSP000003465344I2D: score=1 STRING: ENSP00000346534
    CLEC3BP054523, ENSP000002961304I2D: score=1 STRING: ENSP00000296130
    PRNPP041563I2D: score=1 
    CALM2ENSP000002722984STRING: ENSP00000272298
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA12244047
    GO:0001764neuron migration ISS--
    GO:0007026negative regulation of microtubule depolymerization ISS--
    GO:0007165signal transduction TAS8790420
    GO:0007267cell-cell signaling TAS8790420

    FGF13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF13



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGF13 gene (6 alternative transcripts): 
    NM_001139498.1  NM_001139500.1  NM_001139501.1  NM_001139502.1  NM_004114.3  NM_033642.2  

    Unigene Cluster for FGF13:

    Fibroblast growth factor 13
    Hs.6540  [show with all ESTs]
    Unigene Representative Sequence: NM_004114
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315930(uc004fam.3) ENST00000305414(uc004fan.3 uc011mwk.2)
    ENST00000436198 ENST00000455663 ENST00000448673 ENST00000421460 ENST00000370603
    ENST00000541469 ENST00000441825(uc011mwi.2 uc004faq.3 uc004far.3 uc011mwj.2)

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    hsa-miR-539 hsa-miR-4272 hsa-miR-3692 hsa-miR-570 hsa-miR-421 hsa-miR-511 hsa-miR-641 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidFGF13 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 6): FGF13 (NM_004114)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF13
      QuantiTect SYBR Green Assays in human, mouse, rat FGF13
      QuantiFast Probe-based Assays in human, mouse, rat FGF13

    Additional mRNA sequence: 

    AF100143.1 AF100144.1 AF108756.1 AF199612.1 AF199613.1 AK289960.1 AK297545.1 AK303685.1 
    AK316170.1 BC012347.1 BC034340.1 U66198.1 

    7 DOTS entries:

    DT.212776  DT.452448  DT.91718659  DT.91687058  DT.100033629  DT.95116819  DT.95234959 

    Selected AceView cDNA sequences (see all 94):

    U66198 BQ068644 BE671440 AA427817 AW014749 AA814496 BX332670 AF108756 
    AU117815 Z45127 BU735762 BM973803 AI629013 BQ672978 NM_033642 AA927011 
    BU148846 W23426 Z40861 BM556968 AF199613 AI828849 AF100143 BG179556 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGGCAGT
    FGF13 Expression
    About this image


    FGF13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
             Ventral/hypothalamic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    FGF13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6540

    UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Tissue specificity: Ubiquitously expressed. Predominantly expressed in the nervous system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF13: 
              Parkinson's Disease in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for FGF13
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    QuantiFast Probe-based Assays in human, mouse, rat FGF13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF13 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf131 , 5 fibroblast growth factor 131, 5 95.51(n)1
    99.59(a)1
      X (33.31 cM)5
    141681  NM_010200.21  NP_034330.21 
     590621455 
    chicken
    (Gallus gallus)
    Aves FGF131 fibroblast growth factor 13 83.61(n)
    97.27(a)
      414831  NM_001001743.1  NP_001001743.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF136
    fibroblast growth factor 13
    97(a)
    1 ↔ 1
    GL344120.1(34113-39028)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.132932 Transcribed sequence with strong similarity to protein more 79.37(n)    BX726635.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf13a1 fibroblast growth factor 13a 80.33(n)
    93.44(a)
      492758  NM_001007399.1  NP_001007400.1 


    ENSEMBL Gene Tree for FGF13 (if available)
    TreeFam Gene Tree for FGF13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF13 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
    FGF72  FGF112  FGF102  FGF222  FGF142  
    17 SIMAP similar genes for FGF13 using alignment to 7 protein entries:     FGF13_HUMAN (see all proteins):
    FGF12    FGF14    FGF11    KGFLP1    KGFLP2    PRED3
    FGF9    FGF20    FGF22    FGF7    FGF16    FGF6
    FGF10    FGF4    FGF1    fgf gene    FGF2

    FGF13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF13 (see all 7787)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59039781,2
    C,F--137713260(+) ctact-/GTAA  
            
    gtaag
    6 -- ds50011Minor allele frequency- GTAA:0.11NS 180
    rs357920061,2
    C--137713261(+) TACTG-/GTAA  
            
    TAAGT
    6 -- ds50010--------
    rs30465951,2
    C--137713262(+) TAAGT-/AAGT  
            
    CAGAG
    6 -- ds50010--------
    rs1995098721,2
    --137713365(+) TTACA-/TTTTTC 6 -- ds50010--------
    rs175390591,2
    F--137713369(-) GAAGG-/AAAAAT 1 -- ds50011Minor allele frequency- A:0.06NS 180
    rs1888909201,2
    --137713432(+) AGGAGA/CGAAAT 6 -- ds50010--------
    rs1395874571,2
    C--137713444(+) AGCAAC/GAGAGA 6 -- ds50010--------
    rs175390521,2
    F--137713483(-) TGCTAG/ATATTT 6 -- ds50011Minor allele frequency- A:0.01NS 178
    rs735655031,2
    C,F--137713605(+) TGTTAC/ATATGA 6 -- ds50011Minor allele frequency- A:0.50WA 2
    rs175390451,2
    C,F,H--137713678(-) AGTAGC/AAACTG 6 -- ds500113Minor allele frequency- A:0.03NS NA 1638

    HapMap Linkage Disequilibrium report for FGF13 (137713734 - 137963734 bp, first 250kb of FGF13)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FGF13 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740509CNV Deletion23290073
    esv2675863CNV Deletion23128226
    esv2667866CNV Deletion23128226
    esv2871CNV Deletion18987735
    esv2740507CNV Deletion23290073
    esv2385287CNV Deletion18987734
    esv2740505CNV Deletion23290073
    esv2740508CNV Deletion23290073
    esv2623043CNV Deletion19546169
    esv2740510CNV Deletion23290073

    Human Gene Mutation Database (HGMD): FGF13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF13
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300070    OMIM disorders: --

    17 diseases for FGF13:    
    About MalaCards
    borjeson-forssman-lehmann syndrome    hypertrichosis    pancreatic endocrine tumors    myopia
    mental retardation    ovarian cancer    ischemia    parkinson's disease
    cerebritis    pancreatitis    alzheimer's disease    melanoma
    adenocarcinoma    lung cancer    endotheliitis    breast cancer
    neuronitis


    FGF13 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FGF13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 34.6 6 19456219 (3), 9914447 (1)

    Genetic Association Database (GAD): FGF13
    Human Genome Epidemiology (HuGE) Navigator: FGF13 (1 document)

    Export disorders for FGF13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF13 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with FGF13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. (PubMed id 10071193)1, 2, 9 Gecz J.... Mulley J.C. (Hum. Genet. 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. (PubMed id 15282281)1, 2 Wittmack E.K....Dib-Hajj S.D. (J. Neurosci. 2004)
    5. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. (PubMed id 10644718)1, 2 Munoz-Sanjuan I.... Nathans J. (J. Biol. Chem. 2000)
    6. Identification and characterization of a novel member of the fibroblast growth factor family. (PubMed id 9751161)1, 9 Greene J.M....Alderson R.F. (Eur. J. Neurosci. 1998)
    7. Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. (PubMed id 9914447)1, 9 Yao D.L....Antonaccio M. (Brain Res. 1999)
    8. Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart. (PubMed id 9232594)2, 9 Hartung H....Goldfarb M. (Mech. Dev. 1997)
    9. Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis. (PubMed id 23603273)1 DeStefano G.M....Christiano A.M. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (BMC Cancer 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2258 HGNC: 3670 AceView: FGF13 Ensembl:ENSG00000129682 euGenes: HUgn2258
    ECgene: FGF13 Kegg: 2258 H-InvDB: FGF13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF13 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf13/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF13 gene:
    Search GeneIP for patents involving FGF13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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