Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF13 Gene

protein-coding   GIFtS: 61
GCID: GC0XM137713

fibroblast growth factor 13
 Explore 11 diseases affiliated with
FGF13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGF13    

Aliases
for FGF13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor 131 2
FHF21 2 3
FGF21 2 5
Fibroblast Growth Factor Homologous Factor 22 3
FGF-132 3
FHF-22 3

External Ids:    HGNC: 36701   Entrez Gene: 22582   Ensembl: ENSG000001296827   OMIM: 3000705   UniProtKB: Q929133   

Export aliases for FGF13 gene to outside databases

Previous GC identifers: GC0XM132285 GC0XM134559 GC0XM135658 GC0XM136419 GC0XM137439 GC0XM137541 GC0XM126980


Summaries
for FGF13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF13:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including
embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in
a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible
candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental
retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript
variants encoding different isoforms with different N-termini. (provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and
stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by
negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and
migration in the cerebral cortex and the hippocampus
Function: May regulate voltage-gated sodium channels transport and function
Function: May also play a role in MAPK signaling

Gene Wiki entry for FGF13


Genomic Views
for FGF13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF13 gene promoter:
         GR   SRY   GR-beta   FOXO4   Nkx3-1 v3   GR-alpha   CUTL1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FGF13 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq27.1   HGNC cytogenetic band: Xq26.3

FGF13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF13 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM137713:  view genomic region     (about GC identifiers)

Start:
 137,713,734 bp from pter      End:
 138,304,939 bp from pter
Size:
 591,206 bases      Orientation:
 minus strand

Proteins
for FGF13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913 (See protein sequence)
Recommended Name: Fibroblast growth factor 13  
Size: 245 amino acids; 27564 Da
Subunit: Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity.
Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also
interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity
Subcellular location: Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell
projection, dendrite (By similarity). Nucleus. Cytoplasm. Note=Not secreted (By similarity)
Subcellular location: Isoform 1: Nucleus, nucleolus
Subcellular location: Isoform 2: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for FGF13:
3HBW (3D)        4DCK (3D)    
Secondary accessions: B1AK18 B7Z4M7 B7Z8N0 D3DWH4 O95830 Q9NZH9 Q9NZI0
Alternative splicing: 5 isoforms:  Q92913-1   Q92913-2   Q92913-3   Q92913-4   Q92913-5   

Explore the universe of human proteins at neXtProt for FGF13: NX_Q92913

Post-translational modifications:

  • May be phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92913

    • FGF13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001132970.1  NP_001132972.1  NP_001132973.1  NP_001132974.1  NP_004105.1  NP_378668.1  

    ENSEMBL proteins: 
     ENSP00000322390   ENSP00000303391   ENSP00000396198   ENSP00000406916   ENSP00000411999  
     ENSP00000388688   ENSP00000359635   ENSP00000437903   ENSP00000409276  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): FGF13
    OriGene Custom Protein Services for FGF13 
    GenScript Purified and Recombinant Proteins for FGF13
    Novus Biologicals FGF13 Protein
    Novus Biologicals FGF13 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for FGF13
    Uscn Proteins for FGF13

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8790420
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IPI12244047
    GO:0005874microtubule ISS--
    GO:0005886plasma membrane ISS--


    FGF13 for ontologies           About GeneDecksing



    FGF13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF13 (FGF-13)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FGF13 
    GenScript Custom Superior Antibodies Services for FGF13
    Novus Biologicals FGF13 Antibodies
    Search for Antibodies for FGF13 at Abcam  
    Uscn Antibodies for FGF13
    Search ThermoFisher Antibodies for FGF13

    Assay Products for FGF13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FGF13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FGF13

    Protein Domains /
    Families
    for FGF13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF13 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry Q92913

    ProtoNet protein and cluster: Q92913

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and
    stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by
    negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and
    migration in the cerebral cortex and the hippocampus
    Function: May regulate voltage-gated sodium channels transport and function
    Function: May also play a role in MAPK signaling

         Genatlas biochemistry entry for FGF13:
    fibroblast growth homologous factor 13,expressed principally in the nervous system and skeletal muscle with two
    alternatively spliced isoforms

    miRNA
    Products:            		miRTarBase miRNAs that target FGF13:
    hsa-mir-140-5p (MIRT003962), hsa-mir-16 (MIRT001468)

    OriGene 3'-UTR Clone (see all 6): FGF13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF13
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF13 (see all 17):
    hsa-miR-539 hsa-miR-4272 hsa-miR-3692 hsa-miR-570 hsa-miR-421 hsa-miR-511 hsa-miR-641 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: FGF13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF13 (see all 7)
    OriGene shRNA RFP: FGF13
    OriGene siRNA: FGF13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FGF13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF13 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF13 (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): FGF13 (NM_004114)
    Sino Biological Human cDNA Clone for FGF13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FGF13
    LifeMap BioReagents: cell line associated with FGF13: PureStem 7SMOO32, NCr-fac & Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF13

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15282281
    GO:0008017microtubule binding ISS--
    GO:0008083growth factor activity IEA--
    GO:0017080sodium channel regulator activity IDA15282281
    GO:0030295protein kinase activator activity IGI12244047


    FGF13 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fgf13):
     behavior/neurological  cellular  nervous system 

    FGF13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGF13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    3TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF13 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF13 
        Regulation of Actin Cytoskeleton


    4         Kegg Pathways  (Kegg details for FGF13):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for FGF13 (Q929133 ENSP000003223904) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133873, ENSP000003305724I2D: score=1 STRING: ENSP00000330572
    SCN8AQ9UQD03, ENSP000003465344I2D: score=1 STRING: ENSP00000346534
    CLEC3BP054523, ENSP000002961304I2D: score=1 STRING: ENSP00000296130
    PRNPP041563I2D: score=1 
    CALM2ENSP000002722984STRING: ENSP00000272298
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA12244047
    GO:0001764neuron migration ISS--
    GO:0007026negative regulation of microtubule depolymerization ISS--
    GO:0007165signal transduction TAS8790420
    GO:0007267cell-cell signaling TAS8790420


    FGF13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF13
    Search CenterWatch for drugs/clinical trials and news about FGF13 

    Transcripts
    for FGF13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF13 gene (6 alternative transcripts): 
    NM_001139498.1  NM_001139500.1  NM_001139501.1  NM_001139502.1  NM_004114.3  NM_033642.2  

    Unigene Cluster for FGF13:

    Fibroblast growth factor 13
    Hs.6540  [show with all ESTs]
    Unigene Representative Sequence: NM_004114
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315930(uc004fam.3) ENST00000305414(uc004fan.3 uc011mwk.2)
    ENST00000436198 ENST00000455663 ENST00000448673 ENST00000421460 ENST00000370603
    ENST00000541469 ENST00000441825(uc011mwi.2 uc004faq.3 uc004far.3 uc011mwj.2)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 6): FGF13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF13
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF13 (see all 17):
    hsa-miR-539 hsa-miR-4272 hsa-miR-3692 hsa-miR-570 hsa-miR-421 hsa-miR-511 hsa-miR-641 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: FGF13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF13 (see all 7)
    OriGene shRNA RFP: FGF13
    OriGene siRNA: FGF13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF13 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF13 (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): FGF13 (NM_004114)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF13

    Additional cDNA sequence: 

    AF100143.1 AF100144.1 AF108756.1 AF199612.1 AF199613.1 AK289960.1 AK297545.1 AK303685.1 
    AK316170.1 BC012347.1 BC034340.1 U66198.1 

    7 DOTS entries:

    DT.212776  DT.452448  DT.91718659  DT.91687058  DT.100033629  DT.95116819  DT.95234959 

    24/94 AceView cDNA sequences (see all 94):

    BU148846 BE671440 BU735762 AA427817 Z40861 U66198 Z45127 AU117815 
    BQ068644 BQ672978 BM556968 W23426 BM973803 AA927011 NM_033642 AA814496 
    AI629013 AW014749 AF108756 BX332670 CB121574 BX332669 AI828849 BI597691 

    GeneLoc Exon Structure


    Expression
    for FGF13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAGGCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGF13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    LiverHepatic MesenchymeMesothelial CellsLiver
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)

    See FGF13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF13

    SOURCE GeneReport for Unigene cluster: Hs.6540

    UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Tissue specificity: Ubiquitously expressed. Predominantly expressed in the nervous system

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF13: 
              Parkinson's Disease in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF13
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF13

    Orthologs
    for FGF13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGF13 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGF131 fibroblast growth factor 13 79.93(n)
    91.84(a)    		   414831  NM_001001743.1  NP_001001743.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF136
    FGF136
    		 --
    		 97(a)
    96(a)
    		 possible ortholog
    1 ↔ 1
    		 GL344120.1(34308-37591)
    AAWZ02039478(2606-8061)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.132932 Transcribed sequence with strong similarity to protein more 79.37(n)    BX726635.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf13a1 fibroblast growth factor 13a 79.43(n)
    91.49(a)    		   492758  NM_001007399.1  NP_001007400.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta bnl6
    		 branchless
    		 6(a)
    		 1 → many
    		 3R(15619795-15662539)


    ENSEMBL Gene Tree for FGF13 (if available)
    TreeFam Gene Tree for FGF13 (if available) 

    Paralogs
    for FGF13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF13 gene
    FGF122  FGF52  FGF202  FGF162  FGF42  FGF92  FGF62  FGF32  
    FGF72  FGF112  FGF102  FGF222  FGF142  
    17 SIMAP similar genes for FGF13 using alignment to 7 protein entries:     FGF13_HUMAN (see all proteins):
    FGF12    FGF14    FGF11    KGFLP1    KGFLP2    PRED3
    FGF9    FGF20    FGF22    FGF7    FGF16    FGF6
    FGF10    FGF4    FGF1    fgf gene    FGF2

    FGF13 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6924 NCBI SNPs in FGF13 are shown (see all 6924)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs59039781,2
    		C,F,--137713260(+) CTACT-/GTAA  
                GTAAG     		6 -- ds50011Minor allele frequency- GTAA:0.11NS 180
    rs30465951,2
    		C--137713266(+) TAAGT-/AAGT  
                CAGAG     		6 -- ds50010--------
    rs1995098721,2
    		--137713365(+) TTACA-/TTTTTC 6 -- ds50010--------
    rs175390591,2
    		F--137713366(-) GAAGG-/AAAAAT 6 -- ds50011Minor allele frequency- A:0.06NS 180
    rs1888909201,2
    		--137713432(+) AGGAGA/CGAAAT 6 -- ds50010--------
    rs1395874571,2
    		--137713444(+) AGCAAC/GAGAGA 6 -- ds50010--------
    rs175390521,2
    		F--137713483(-) TGCTAG/ATATTT 6 -- ds50011Minor allele frequency- A:0.01NS 178
    rs735655031,2
    		C,--137713605(+) TGTTAC/ATATGA 6 -- ds50011Minor allele frequency- A:0.50WA 2
    rs175390451,2
    		C,F,H,--137713678(-) AGTAGC/AAACTG 6 -- ds500113Minor allele frequency- A:0.03NS NA 1638
    rs1816879231,2
    		--137713763(+) TATTCA/GGTGCG 6 -- ut310--------

    HapMap Linkage Disequilibrium report for FGF13 (137713734 - 137963734 bp, first 250kb of FGF13)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for FGF13
         3 CNVs: 83772 97007 97006
         7 Indels: 41240 41795 103283 41239 83773 62983 47770

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF13
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF13

    Disorders / Diseases
    for FGF13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF13 for disorders           About GeneDecksing

    OMIM gene information: 300070    OMIM disorders: --

    11 diseases for FGF13:    About MalaCards
    borjeson-forssman-lehmann syndrome    pancreatic endocrine tumors    myopia    ovarian cancer
    parkinson's disease    ischemia    pancreatitis    cerebritis
    melanoma    breast cancer    adenocarcinoma

    1 Novoseek disease relationship for FGF13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 34.6 6 19456219 (3), 9914447 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF13 (1 document)

    Export disorders for FGF13 gene to outside databases

    Publications
    for FGF13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF13 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with FGF13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (1996)
    2. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. (PubMed id 10071193)1, 2, 9 Gecz J.... Mulley J.C. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. (PubMed id 15282281)1, 2 Wittmack E.K....Dib-Hajj S.D. (2004)
    5. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. (PubMed id 10644718)1, 2 Munoz-Sanjuan I.... Nathans J. (2000)
    6. Identification and characterization of a novel member of the fibroblast growth factor family. (PubMed id 9751161)1, 9 Greene J.M....Alderson R.F. (1998)
    7. Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. (PubMed id 9914447)1, 9 Yao D.L....Antonaccio M. (1999)
    8. Murine FGF-12 and FGF-13: expression in embryonic ner vous system, connective tissue and heart. (PubMed id 9232594)2, 9 Hartung H....Goldfarb M. (1997)
    9. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
    10. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. (PubMed id 21817159)2 Wang C.... Pitt G.S. (2011)

    External Searches for FGF13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGF13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2258 HGNC: 3670 AceView: FGF13 Ensembl:ENSG00000129682 euGenes: HUgn2258
    ECgene: FGF13 Kegg: 2258 H-InvDB: FGF13

    Other Databases showing FGF13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGF13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF13 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf13/

    Intellectual Property
    for FGF13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF13 gene:
    Search GeneIP for patents involving FGF13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FGF13 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FGF13 (FGF-13)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FGF13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF13  
     OriGene Protein Over-expression Lysate for FGF13   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FGF13   OriGene 3'-UTR Clone for FGF13  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FGF13   OriGene Custom Protein Services for FGF13  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGF13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF13
     GenScript Purified and Recombinant Proteins for FGF13 GenScript cDNA clones with any tag delivered in your preferred vector for FGF13
     GenScript Custom Assay Services for FGF13 GenScript Custom Superior Antibodies Services for FGF13
     GenScript Custom overexpressing Cell Line Services for FGF13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FGF13 promoter
     Search Chromatin IP Primers for FGF13
     RT2 qPCR Primer Assay in human, mouse, rat FGF13
     GNC Network for FGF13
     SABiosciences PCR Arrays including human, mouse, rat FGF13
     Search Tocris compounds for FGF13
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for FGF13
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FGF13 antibodies
     FGF13 proteins
     FGF13 lysates
     Search for Antibodies for FGF13 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FGF13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FGF13




     FGF13 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Line associated with FGF13: PureStem 7SMOO32, NCr-fac & Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF13
     SwitchGear 3'UTR luciferase reporter plasmids for FGF13
     SwitchGear Promoter luciferase reporter plasmids for FGF13
     Search ThermoFisher Antibodies for FGF13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF13
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FGF13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4