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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF13 Gene

protein-coding   GIFtS: 64
GCID: GC0XM137713

Fibroblast Growth Factor 13

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibroblast Growth Factor 131 2
Fibroblast Growth Factor Homologous Factor 21 2 3
FGF-132 3
FHF-22 3
FHF22 3
FGF22 5

External Ids:    HGNC: 36701   Entrez Gene: 22582   Ensembl: ENSG000001296827   OMIM: 3000705   UniProtKB: Q929133   

Export aliases for FGF13 gene to outside databases

Previous GC identifers: GC0XM132285 GC0XM134559 GC0XM135658 GC0XM136419 GC0XM137439 GC0XM137541 GC0XM126980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF13 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene
is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS),
making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms
of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in
several transcript variants encoding different isoforms with different N-termini. (provided by RefSeq, Nov 2008)

GeneCards Summary for FGF13 Gene: 
FGF13 (fibroblast growth factor 13) is a protein-coding gene. Diseases associated with FGF13 include borjeson-forssman-lehmann syndrome, and pancreatic endocrine tumor, and among its related super-pathways are Regulation of actin cytoskeleton and Rac1 Pathway. GO annotations related to this gene include growth factor activity and ion channel binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and
stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by
negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and
migration in the cerebral cortex and the hippocampus
Function: May regulate voltage-gated sodium channels transport and function
Function: May also play a role in MAPK signaling

Gene Wiki entry for FGF13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF13 gene promoter:
         GR   SRY   GR-beta   FOXO4   Nkx3-1 v3   GR-alpha   CUTL1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FGF13 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq27.1   HGNC cytogenetic band: Xq26.3

FGF13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF13 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM137713:  view genomic region     (about GC identifiers)

Start:
137,713,734 bp from pter      End:
138,304,939 bp from pter
Size:
591,206 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913 (See protein sequence)
Recommended Name: Fibroblast growth factor 13  
Size: 245 amino acids; 27564 Da
Subunit: Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity.
Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May
also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity
Subcellular location: Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity).
Cell projection, dendrite (By similarity). Nucleus. Cytoplasm. Note=Not secreted (By similarity)
Subcellular location: Isoform 1: Nucleus, nucleolus
Subcellular location: Isoform 2: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for FGF13:
3HBW (3D)        4DCK (3D)    
Secondary accessions: B1AK18 B7Z4M7 B7Z8N0 D3DWH4 O95830 Q9NZH9 Q9NZI0
Alternative splicing: 5 isoforms:  Q92913-1   Q92913-2   Q92913-3   Q92913-4   Q92913-5   

Explore the universe of human proteins at neXtProt for FGF13: NX_Q92913

Explore proteomics data for FGF13 at MOPED 

Post-translational modifications:

  • UniProtKB: May be phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92913

  • FGF13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF13 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001132970.1  NP_001132972.1  NP_001132973.1  NP_001132974.1  NP_004105.1  NP_378668.1  

    ENSEMBL proteins: 
     ENSP00000322390   ENSP00000303391   ENSP00000396198   ENSP00000406916   ENSP00000411999  
     ENSP00000388688   ENSP00000359635   ENSP00000437903   ENSP00000409276  

    Human Recombinant Protein Products for FGF13: 
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    ProSpec Recombinant Protein for FGF13
    Cloud-Clone Corp. Proteins for FGF13 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA8790420
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IPI12244047
    GO:0005874microtubule ISS--

    FGF13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry Q92913

    ProtoNet protein and cluster: Q92913

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Similarity: Belongs to the heparin-binding growth factors family


    FGF13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF13_HUMAN, Q92913
    Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and
    stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by
    negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and
    migration in the cerebral cortex and the hippocampus
    Function: May regulate voltage-gated sodium channels transport and function
    Function: May also play a role in MAPK signaling

         Genatlas biochemistry entry for FGF13:
    fibroblast growth homologous factor 13,expressed principally in the nervous system and skeletal muscle with two
    alternatively spliced isoforms

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15282281
    GO:0008017microtubule binding ISS--
    GO:0008083growth factor activity IEA--
    GO:0017080sodium channel regulator activity IDA15282281
    GO:0030295protein kinase activator activity IGI12244047
         
    FGF13 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf13):
     behavior/neurological  cellular  nervous system 

    FGF13 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF13 
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF13 (see all 17):
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    SwitchGear 3'UTR luciferase reporter plasmidFGF13 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF13 About   (see all 20)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF13 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF13
        Regulation of Actin Cytoskeleton



    5/6         Kegg Pathways  (Kegg details for FGF13) (see all 6):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Proteoglycans in cancer


    FGF13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for FGF13 (Q929133 ENSP000003223904) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133873, ENSP000003305724I2D: score=1 STRING: ENSP00000330572
    SCN8AQ9UQD03, ENSP000003465344I2D: score=1 STRING: ENSP00000346534
    CLEC3BP054523, ENSP000002961304I2D: score=1 STRING: ENSP00000296130
    PRNPP041563I2D: score=1 
    CALM2ENSP000002722984STRING: ENSP00000272298
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA12244047
    GO:0001764neuron migration ISS--
    GO:0007026negative regulation of microtubule depolymerization ISS--
    GO:0007165signal transduction TAS8790420
    GO:0007267cell-cell signaling TAS8790420

    FGF13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF13

    Search CenterWatch for drugs/clinical trials and news about FGF13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF13 gene (6 alternative transcripts): 
    NM_001139498.1  NM_001139500.1  NM_001139501.1  NM_001139502.1  NM_004114.3  NM_033642.2  

    Unigene Cluster for FGF13:

    Fibroblast growth factor 13
    Hs.6540  [show with all ESTs]
    Unigene Representative Sequence: NM_004114
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315930(uc004fam.3) ENST00000305414(uc004fan.3 uc011mwk.2)
    ENST00000436198 ENST00000455663 ENST00000448673 ENST00000421460 ENST00000370603
    ENST00000541469 ENST00000441825(uc011mwi.2 uc004faq.3 uc004far.3 uc011mwj.2)


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    Additional mRNA sequence: 

    AF100143.1 AF100144.1 AF108756.1 AF199612.1 AF199613.1 AK289960.1 AK297545.1 AK303685.1 
    AK316170.1 BC012347.1 BC034340.1 U66198.1 

    7 DOTS entries:

    DT.212776  DT.452448  DT.91718659  DT.91687058  DT.100033629  DT.95116819  DT.95234959 

    24/94 AceView cDNA sequences (see all 94):

    AI629013 AA927011 AA814496 W23426 AF108756 BM973803 BM556968 BQ672978 
    Z40861 NM_033642 BU148846 BE671440 AU117815 Z45127 BX332670 BU735762 
    U66198 AA427817 AW014749 BQ068644 CF593780 AI458694 AW949557 BI545123 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF13 expression in normal human tissues (normalized intensities)      FGF13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGGCAGT
    FGF13 Expression
    About this image


    FGF13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             Septum   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             ES03(HES-3)
             ESI-053   
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Dorsal Root Ganglion   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Pharynx
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon

    See FGF13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF13

    SOURCE GeneReport for Unigene cluster: Hs.6540

    UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913
    Tissue specificity: Ubiquitously expressed. Predominantly expressed in the nervous system

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF13: 
              Parkinson's Disease in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF13 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf131 , 5 fibroblast growth factor 131, 5 95.51(n)1
    99.59(a)1
      X (33.31 cM)5
    141681  NM_010200.21  NP_034330.21 
     590621455 
    chicken
    (Gallus gallus)
    Aves FGF131 fibroblast growth factor 13 79.93(n)
    91.84(a)
      414831  NM_001001743.1  NP_001001743.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF136
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL344120.1(34113-39028)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.132932 Transcribed sequence with strong similarity to protein more 79.37(n)    BX726635.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf13a1 fibroblast growth factor 13a 79.43(n)
    91.49(a)
      492758  NM_001007399.1  NP_001007400.1 


    ENSEMBL Gene Tree for FGF13 (if available)
    TreeFam Gene Tree for FGF13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF13 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
    FGF72  FGF112  FGF102  FGF222  FGF142  
    17 SIMAP similar genes for FGF13 using alignment to 7 protein entries:     FGF13_HUMAN (see all proteins):
    FGF12    FGF14    FGF11    KGFLP1    KGFLP2    PRED3
    FGF9    FGF20    FGF22    FGF7    FGF16    FGF6
    FGF10    FGF4    FGF1    fgf gene    FGF2

    FGF13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7787 SNPs in FGF13 are shown (see all 7787)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59039781,2
    C,F--137713260(+) ctact-/GTAA  
            
    gtaag
    6 -- ds50011Minor allele frequency- GTAA:0.11NS 180
    rs357920061,2
    C--137713261(+) TACTG-/GTAA  
            
    TAAGT
    6 -- ds50010--------
    rs30465951,2
    C--137713262(+) TAAGT-/AAGT  
            
    CAGAG
    6 -- ds50010--------
    rs1995098721,2
    --137713365(+) TTACA-/TTTTTC 6 -- ds50010--------
    rs175390591,2
    F--137713369(-) GAAGG-/AAAAAT 1 -- ds50011Minor allele frequency- A:0.06NS 180
    rs1888909201,2
    --137713432(+) AGGAGA/CGAAAT 6 -- ds50010--------
    rs1395874571,2
    C--137713444(+) AGCAAC/GAGAGA 6 -- ds50010--------
    rs175390521,2
    F--137713483(-) TGCTAG/ATATTT 6 -- ds50011Minor allele frequency- A:0.01NS 178
    rs735655031,2
    C,F--137713605(+) TGTTAC/ATATGA 6 -- ds50011Minor allele frequency- A:0.50WA 2
    rs175390451,2
    C,F,H--137713678(-) AGTAGC/AAACTG 6 -- ds500113Minor allele frequency- A:0.03NS NA 1638

    HapMap Linkage Disequilibrium report for FGF13 (137713734 - 137963734 bp, first 250kb of FGF13)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for FGF13 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740509CNV Deletion23290073
    esv2675863CNV Deletion23128226
    esv2667866CNV Deletion23128226
    esv2871CNV Deletion18987735
    esv2740507CNV Deletion23290073
    esv2385287CNV Deletion18987734
    esv2740505CNV Deletion23290073
    esv2740508CNV Deletion23290073
    esv2623043CNV Deletion19546169
    esv2740510CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300070    OMIM disorders: --

    15 diseases for FGF13:    About MalaCards
    borjeson-forssman-lehmann syndrome    pancreatic endocrine tumor    myopia    mental retardation
    ovarian cancer    ischemia    parkinson's disease    cerebritis
    pancreatitis    melanoma    adenocarcinoma    alzheimer's disease
    endotheliitis    breast cancer    neuronitis


    FGF13 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for FGF13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 34.6 6 19456219 (3), 9914447 (1)

    Genetic Association Database (GAD): FGF13
    Human Genome Epidemiology (HuGE) Navigator: FGF13 (1 document)

    Export disorders for FGF13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF13 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with FGF13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (1996)
    2. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. (PubMed id 10071193)1, 2, 9 Gecz J.... Mulley J.C. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. (PubMed id 15282281)1, 2 Wittmack E.K....Dib-Hajj S.D. (2004)
    5. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. (PubMed id 10644718)1, 2 Munoz-Sanjuan I.... Nathans J. (2000)
    6. Identification and characterization of a novel member of the fibroblast growth factor family. (PubMed id 9751161)1, 9 Greene J.M....Alderson R.F. (1998)
    7. Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. (PubMed id 9914447)1, 9 Yao D.L....Antonaccio M. (1999)
    8. Murine FGF-12 and FGF-13: expression in embryonic ner vous system, connective tissue and heart. (PubMed id 9232594)2, 9 Hartung H....Goldfarb M. (1997)
    9. Position effect on FGF13 associated with X-linked cong enital generalized hypertrichosis. (PubMed id 23603273)1 DeStefano G.M....Christiano A.M. (2013)
    10. Genetic association with overall survival of taxane-tr eated lung cancer patients - a genome-wide association study in human lymphoblas toid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2258 HGNC: 3670 AceView: FGF13 Ensembl:ENSG00000129682 euGenes: HUgn2258
    ECgene: FGF13 Kegg: 2258 H-InvDB: FGF13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF13 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf13/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF13 gene:
    Search GeneIP for patents involving FGF13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Proteins for FGF13
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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