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Aliases for FGF13 Gene

Aliases for FGF13 Gene

  • Fibroblast Growth Factor 13 2 3
  • Fibroblast Growth Factor Homologous Factor 2 2 3 4
  • FGF-13 3 4
  • FHF-2 3 4
  • FGF2 3 6
  • FHF2 3 4

External Ids for FGF13 Gene

Previous GeneCards Identifiers for FGF13 Gene

  • GC0XM132285
  • GC0XM134559
  • GC0XM135658
  • GC0XM136419
  • GC0XM137439
  • GC0XM137541
  • GC0XM137713
  • GC0XM126980

Summaries for FGF13 Gene

Entrez Gene Summary for FGF13 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

GeneCards Summary for FGF13 Gene

FGF13 (Fibroblast Growth Factor 13) is a Protein Coding gene. Diseases associated with FGF13 include borjeson-forssman-lehmann syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and ion channel binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF13 Gene

  • Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.

  • May regulate voltage-gated sodium channels transport and function.

  • May also play a role in MAPK signaling.

Gene Wiki entry for FGF13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF13 Gene

Genomics for FGF13 Gene

Regulatory Elements for FGF13 Gene

Genomic Location for FGF13 Gene

Start:
138,631,573 bp from pter
End:
139,222,889 bp from pter
Size:
591,317 bases
Orientation:
Minus strand

Genomic View for FGF13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF13 Gene

Proteins for FGF13 Gene

  • Protein details for FGF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92913-FGF13_HUMAN
    Recommended name:
    Fibroblast growth factor 13
    Protein Accession:
    Q92913
    Secondary Accessions:
    • B1AK18
    • B7Z4M7
    • B7Z8N0
    • D3DWH4
    • O95830
    • Q9NZH9
    • Q9NZI0

    Protein attributes for FGF13 Gene

    Size:
    245 amino acids
    Molecular mass:
    27564 Da
    Quaternary structure:
    • Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity.

    Three dimensional structures from OCA and Proteopedia for FGF13 Gene

    Alternative splice isoforms for FGF13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF13 Gene

Proteomics data for FGF13 Gene at MOPED

Post-translational modifications for FGF13 Gene

No data available for DME Specific Peptides for FGF13 Gene

Domains for FGF13 Gene

Graphical View of Domain Structure for InterPro Entry

Q92913

UniProtKB/Swiss-Prot:

FGF13_HUMAN :
  • Q92913
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF13: view

No data available for Gene Families for FGF13 Gene

Function for FGF13 Gene

Molecular function for FGF13 Gene

GENATLAS Biochemistry: fibroblast growth homologous factor 13,expressed principally in the nervous system and skeletal muscle with two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.
UniProtKB/Swiss-Prot Function: May regulate voltage-gated sodium channels transport and function.
UniProtKB/Swiss-Prot Function: May also play a role in MAPK signaling.

Gene Ontology (GO) - Molecular Function for FGF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15282281
GO:0008017 microtubule binding ISS --
GO:0008083 growth factor activity IEA --
GO:0017080 sodium channel regulator activity IDA 15282281
GO:0030295 protein kinase activator activity IGI 12244047
genes like me logo Genes that share ontologies with FGF13: view

Phenotypes for FGF13 Gene

genes like me logo Genes that share phenotypes with FGF13: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGF13 Gene

Localization for FGF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF13 Gene

Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm. Note=Not secreted. {ECO:0000250}.
Isoform 1: Nucleus, nucleolus.
Isoform 2: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF13 Gene COMPARTMENTS Subcellular localization image for FGF13 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FGF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 8790420
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IPI 12244047
GO:0005874 microtubule ISS --
genes like me logo Genes that share ontologies with FGF13: view

Pathways for FGF13 Gene

SuperPathways for FGF13 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF13: view

Interacting Proteins for FGF13 Gene

Selected Interacting proteins: Q92913-FGF13_HUMAN for FGF13 Gene via I2D

Gene Ontology (GO) - Biological Process for FGF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 12244047
GO:0001764 neuron migration ISS --
GO:0007026 negative regulation of microtubule depolymerization ISS --
GO:0007165 signal transduction TAS 8790420
GO:0007267 cell-cell signaling TAS 8790420
genes like me logo Genes that share ontologies with FGF13: view

Transcripts for FGF13 Gene

Unigene Clusters for FGF13 Gene

Fibroblast growth factor 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF13 Gene

No ASD Table

Relevant External Links for FGF13 Gene

GeneLoc Exon Structure for
FGF13
ECgene alternative splicing isoforms for
FGF13

Expression for FGF13 Gene

mRNA expression in normal human tissues for FGF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF13 Gene

This gene is overexpressed in Brain - Hippocampus (6.0), Brain - Amygdala (4.7), Brain - Anterior cingulate cortex (BA24) (4.5), and Brain - Nucleus accumbens (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGF13 Gene

SOURCE GeneReport for Unigene cluster for FGF13 Gene Hs.6540

mRNA Expression by UniProt/SwissProt for FGF13 Gene

Q92913-FGF13_HUMAN
Tissue specificity: Ubiquitously expressed. Predominantly expressed in the nervous system.
genes like me logo Genes that share expressions with FGF13: view

Orthologs for FGF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF13 35
  • 100 (n)
  • 100 (a)
FGF13 36
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF13 35
  • 95.51 (n)
  • 99.59 (a)
FGF13 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF13 36
  • 78 (a)
OneToOne
LOC492174 35
  • 93.61 (n)
  • 99.18 (a)
mouse
(Mus musculus)
Mammalia Fgf13 35
  • 95.51 (n)
  • 99.59 (a)
Fgf13 16
Fgf13 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF13 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF13 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf13 35
  • 94.9 (n)
  • 99.45 (a)
chicken
(Gallus gallus)
Aves FGF13 35
  • 83.61 (n)
  • 97.27 (a)
FGF13 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF13 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf13 35
  • 79.96 (n)
  • 92.9 (a)
Str.13293 35
zebrafish
(Danio rerio)
Actinopterygii fgf13a 35
  • 80.33 (n)
  • 93.44 (a)
fgf13a 36
  • 87 (a)
OneToOne
Species with no ortholog for FGF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF13 Gene

ENSEMBL:
Gene Tree for FGF13 (if available)
TreeFam:
Gene Tree for FGF13 (if available)

Paralogs for FGF13 Gene

Paralogs for FGF13 Gene

genes like me logo Genes that share paralogs with FGF13: view

Variants for FGF13 Gene

Sequence variations from dbSNP and Humsavar for FGF13 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs590 -- 138,754,351(+) TGAAA(A/G)AATAA intron-variant
rs591 -- 138,754,725(+) caaac(A/C)cctac intron-variant
rs657 -- 138,664,020(+) TAAAT(G/T)AGGTT intron-variant
rs17378 -- 139,149,517(+) TAGAA(C/T)GTCCT intron-variant
rs17393 -- 138,925,280(+) GTTAC(A/G)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF13 Gene

Variant ID Type Subtype PubMed ID
nsv525867 CNV Gain 19592680
nsv510563 CNV Loss 20534489
esv268077 CNV Insertion 20981092
nsv524567 CNV Gain 19592680
esv2740505 CNV Deletion 23290073
esv2740507 CNV Deletion 23290073
esv2667866 CNV Deletion 23128226
esv2740508 CNV Deletion 23290073
nsv7115 CNV Insertion 18451855
nsv523403 CNV Gain 19592680
esv2675863 CNV Deletion 23128226
esv2477107 CNV Deletion 19546169
esv2740509 CNV Deletion 23290073
esv2385287 CNV Deletion 18987734
esv2871 CNV Deletion 18987735
esv1007548 CNV Deletion 20482838
esv2623043 CNV Deletion 19546169
esv8695 CNV Loss 19470904
esv2740510 CNV Deletion 23290073
esv259924 OTHER Complex 20981092

Relevant External Links for FGF13 Gene

HapMap Linkage Disequilibrium report
FGF13
Human Gene Mutation Database (HGMD)
FGF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF13 Gene

Disorders for FGF13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FGF13 Gene including...

Search for FGF13 Gene in MalaCards »

(1) Novoseek inferred disease relationships for FGF13 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 34.6 4

Relevant External Links for FGF13

Genetic Association Database (GAD)
FGF13
Human Genome Epidemiology (HuGE) Navigator
FGF13
genes like me logo Genes that share disorders with FGF13: view

No data available for UniProtKB/Swiss-Prot for FGF13 Gene

Publications for FGF13 Gene

  1. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. (PMID: 10071193) Gecz J. … Mulley J.C. (Hum. Genet. 1999) 3 4 23
  2. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PMID: 8790420) Smallwood P.M. … Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  3. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. (PMID: 15282281) Wittmack E.K. … Dib-Hajj S.D. (J. Neurosci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart. (PMID: 9232594) Hartung H. … Goldfarb M. (Mech. Dev. 1997) 4 23

Products for FGF13 Gene

Sources for FGF13 Gene

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