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FGF12 Gene

protein-coding   GIFtS: 58
GCID: GC03M191859

Fibroblast Growth Factor 12


(Previous symbol: FGF12B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 121 2     Fibroblast Growth Factor 12B1 2
FGF12B1 2 3     Fibroblast Growth Factor FGF-12b1 2
Fibroblast Growth Factor Homologous Factor 11 2 3     FGF-122 3
Myocyte-Activating Factor1 2 3     FHF-12 3
FHF12 3 5     

External Ids:    HGNC: 36681   Entrez Gene: 22572   Ensembl: ENSG000001142797   OMIM: 6015135   UniProtKB: P613283   

Export aliases for FGF12 gene to outside databases

Previous GC identifers: GC03M188826 GC03M193121 GC03M193261 GC03M193180 GC03M193342 GC03M189260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF12 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This
growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains
clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected
into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of
this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms
have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF12 Gene:
FGF12 (fibroblast growth factor 12) is a protein-coding gene. GO annotations related to this gene include growth factor activity and ion channel binding. An important paralog of this gene is FGF16.

UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328
Function: Probably involved in nervous system development and function

Gene Wiki entry for FGF12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF12 gene promoter:
         HFH-3   Sp1   GATA-1   C/EBPalpha   Egr-2   FOXI1   AREB6   FAC1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FGF12 promoter sequence
   Search Chromatin IP Primers for FGF12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q28

FGF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF12 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M191859:  view genomic region     (about GC identifiers)

Start:
191,857,182 bp from pter      End:
192,485,553 bp from pter
Size:
628,372 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328 (See protein sequence)
Recommended Name: Fibroblast growth factor 12  
Size: 243 amino acids; 27399 Da
Subunit: Interacts with the C-terminal region of SCN9A (By similarity)
1 PDB 3D structure from and Proteopedia for FGF12:
1Q1U (3D)    
Secondary accessions: B2R6B7 B2R976 O35339 P70376 Q8TBG5 Q92912 Q93001
Alternative splicing: 2 isoforms:  P61328-1   P61328-2   

Explore the universe of human proteins at neXtProt for FGF12: NX_P61328

Explore proteomics data for FGF12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004104.3  NP_066360.1  

    ENSEMBL proteins: 
     ENSP00000393686   ENSP00000413496   ENSP00000400948   ENSP00000397635   ENSP00000410125  
     ENSP00000412904   ENSP00000395517   ENSP00000264730  

    FGF12 Human Recombinant Protein Products:

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    OriGene Purified Proteins for FGF12
    OriGene Protein Over-expression Lysate for FGF12
    OriGene MassSpec for FGF12
    OriGene Custom Protein Services for FGF12
    GenScript Custom Purified and Recombinant Proteins Services for FGF12
    Novus Biologicals FGF12 Proteins
    Novus Biologicals FGF12 Lysates
    Sino Biological Recombinant Protein for FGF12
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FGF12
    Cloud-Clone Corp. Proteins for FGF12

     
    Search eBioscience for Proteins for FGF12 

     
    antibodies-online proteins for FGF12 (25 products) 

     
    antibodies-online peptides for FGF12

    FGF12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals FGF12 Antibodies
    Abcam antibodies for FGF12
    Cloud-Clone Corp. Antibodies for FGF12
    Search ThermoFisher Antibodies for FGF12
    antibodies-online antibodies for FGF12 (35 products) 

    FGF12 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF12
    Cloud-Clone Corp. CLIAs for FGF12
    Search eBioscience for ELISAs for FGF12 
    antibodies-online kits for FGF12 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028254 FGF12
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry P61328

    ProtoNet protein and cluster: P61328

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF12_HUMAN, P61328
    Function: Probably involved in nervous system development and function

         Genatlas biochemistry entry for FGF12:
    fibroblast growth homologous factor 12,expressed principally in the nervous system

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104NOT fibroblast growth factor receptor binding IDA12815063
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IDA12815063
    GO:0017080sodium channel regulator activity ISS12401812
         
    Find genes that share ontologies with FGF12           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf12):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with FGF12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fgf12tm1Gol for FGF12

       genOway: Develop your customized and physiologically relevant rodent model for FGF12

    miRNA
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    Block miRNA regulation of human, mouse, rat FGF12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF12 (see all 64):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-19b-2* hsa-miR-429 hsa-miR-1224-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidFGF12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF12
    Predesigned siRNA for gene silencing in human, mouse, rat FGF12

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FGF12 (NM_021032)
    Sino Biological Human cDNA Clone for FGF12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF12

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    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF12 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF12_HUMAN, P61328: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular4
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10049777
    GO:0005634nucleus IDA8790420

    Find genes that share ontologies with FGF12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF12 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with FGF12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF12 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF12
        Regulation of Actin Cytoskeleton



    Selected Kegg Pathways  (Kegg details for FGF12) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF12: 
              Huntington's Disease in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FGF12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for FGF12 (P613283 ENSP000004134964) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133873, ENSP000003305724I2D: score=2 STRING: ENSP00000330572
    MAPK13O152643, ENSP000002112874I2D: score=1 STRING: ENSP00000211287
    THAP1Q9NVV93I2D: score=1 
    EGFRENSP000002754934STRING: ENSP00000275493
    FGFR1ENSP000003802804STRING: ENSP00000380280
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003254regulation of membrane depolarization IEA--
    GO:0007165signal transduction TAS10049777
    GO:0007254JNK cascade IPI12815063
    GO:0007267cell-cell signaling TAS10049777
    GO:0007268synaptic transmission IEA--

    Find genes that share ontologies with FGF12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF12 gene (2 alternative transcripts): 
    NM_004113.5  NM_021032.4  

    Unigene Cluster for FGF12:

    Fibroblast growth factor 12
    Hs.390250  [show with all ESTs]
    Unigene Representative Sequence: NM_021032
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445105(uc003fsy.3) ENST00000454309(uc003fsx.3) ENST00000440901
    ENST00000450716 ENST00000430714 ENST00000448795 ENST00000418610 ENST00000466144
    ENST00000491636 ENST00000264730
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGF12 (see all 64):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-19b-2* hsa-miR-429 hsa-miR-1224-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidFGF12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGF12
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    GenScript: all cDNA clones in your preferred vector (see all 2): FGF12 (NM_021032)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF12
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FGF12
      QuantiFast Probe-based Assays in human, mouse, rat FGF12

    Additional mRNA sequence: 

    AK123610.1 AK125307.1 AK312513.1 AK313671.1 BC022524.1 U66197.1 U76381.2 Z70276.1 

    13 DOTS entries:

    DT.455272  DT.95371016  DT.120928120  DT.446452  DT.120928142  DT.92433456  DT.97838610  DT.306832 
    DT.435560  DT.120928172  DT.92433451  DT.99964359  DT.120928158 

    Selected AceView cDNA sequences (see all 125):

    Z39575 BM663783 BI494807 F06170 BQ955152 U66197 CB959964 AA365577 
    F06169 AI928840 AI815912 AA131493 Z44867 Z45931 BF507728 AA214486 
    NM_021032 Z40635 Z43503 BG208688 Z70276 CA390609 BG182349 AK123610 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGCAAAGA
    FGF12 Expression
    About this image


    FGF12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    FGF12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390250

    UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328
    Tissue specificity: Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory
    bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar
    nuclei, cortex and multiple midbrain structures

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF12: 
              Huntington's Disease in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FGF12
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF12
    QuantiTect SYBR Green Assays in human, mouse, rat FGF12
    QuantiFast Probe-based Assays in human, mouse, rat FGF12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf121 , 5 fibroblast growth factor 121, 5 94.24(n)1
    100(a)1
      16 (19.38 cM)5
    141671  NM_183064.41  NP_898887.11 
     281601205 
    chicken
    (Gallus gallus)
    Aves FGF121 fibroblast growth factor 12 89.85(n)
    98.77(a)
      395704  NM_204888.1  NP_990219.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF126
    fibroblast growth factor 12
    97(a)
    1 ↔ 1
    GL343669.1(155736-286680)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844224.12   -- 84.92(n)    BX844224.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf12a1 fibroblast growth factor 12a 79.44(n)
    90.83(a)
      777735  NM_001077782.1  NP_001071250.1 


    ENSEMBL Gene Tree for FGF12 (if available)
    TreeFam Gene Tree for FGF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF12 gene
    FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    17 SIMAP similar genes for FGF12 using alignment to 6 protein entries:     FGF12_HUMAN (see all proteins):
    FGF13    FGF14    FGF11    FGF9    FGF16    KGFLP1
    KGFLP2    FGF20    FGF22    FGF7    PRED3    FGF10
    FGF1    FGF6    FGF4    fgf gene    FGF2

    Find genes that share paralogs with FGF12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF12 (see all 12825)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98363431,2
    C,F,A,Huntested1191918451(+) ACTCCA/G/TTCAGT 2 -- int14EA NS WA 416
    rs677847491,2
    C--189510233(+) ACTCC-/GAGAGA
            
    GAGAG
    2 -- int10--------
    rs106530531,2
    C--191747723(+) TATTT-/AC    
       
    /ACAC
    acaca
    2 -- int10--------
    rs1126459151,2
    C,F--191856716(+) GCATTA/GTTTAT 2 -- ds50010--------
    rs667426031,2
    C--191856717(+) ATTAT-/TTTG  
            
    TTATT
    2 -- ds50010--------
    rs562850441,2
    C--191856719(+) TATTT-/GTTT  
            
    ATTTA
    2 -- ds50011Minor allele frequency- GTTT:0.50NA 2
    rs67747321,2
    C,F,H--191856805(+) TGGTAT/CGTTAT 2 -- ds500115Minor allele frequency- C:0.07EA NS NA WA 1986
    rs1435279391,2
    --191856830(+) ATGAAC/TGTACT 2 -- ds50010--------
    rs612427701,2
    C,F--191856866(+) ATGTCA/CGGTTG 2 -- ds50019Minor allele frequency- C:0.12NA CSA WA EA 369
    rs1396143281,2
    C--191856927(+) TTCTA-/CAAAAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF12 (191857182 - 192107182 bp, first 250kb of FGF12)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FGF12 (see all 61):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2424454CNV Deletion19546169
    esv1378514CNV Deletion17803354
    esv2570037CNV Deletion19546169
    esv2646061CNV Deletion19546169
    esv2673240CNV Deletion23128226
    esv2674424CNV Deletion23128226
    esv2726413CNV Deletion23290073
    esv1987177CNV Deletion18987734
    esv990918CNV Deletion20482838
    esv1008599CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601513    OMIM disorders: --


    Find genes that share disorders with FGF12           About GenesLikeMe

    Genetic Association Database (GAD): FGF12
    Human Genome Epidemiology (HuGE) Navigator: FGF12 (4 documents)

    Export disorders for FGF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF12 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with FGF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum. (PubMed id 21139019)1, 4 Walsh K.M....Hoh J. (Endocr. Relat. Cancer 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    6. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PubMed id 19043545)1, 4 Gieger C....Suhre K. (PLoS Genet. 2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart. (PubMed id 10049777)1, 2 Kok L.D.S....Fung K.-P. (Biochem. Biophys. Res. Commun. 1999)
    10. Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29--&gt;3qter by fluorescence in situ hybridization. (PubMed id 9345906)1, 3 Liu Y. and Chiu I.M. (Cytogenet. Cell Genet. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2257 HGNC: 3668 AceView: FGF12 Ensembl:ENSG00000114279 euGenes: HUgn2257
    ECgene: FGF12 Kegg: 2257 H-InvDB: FGF12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGF12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF12 gene:
    Search GeneIP for patents involving FGF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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