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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF12 Gene

protein-coding GIFtS: 60
GCID: GC03M191859

fibroblast growth factor 12

(Previous symbol: FGF12B)

Explore 10 diseases affiliated with
FGF12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 12¹ ²		FGF-12² ³
FHF1¹ ² ³ ⁵		FHF-1² ³
FGF12B¹ ² ³		Fibroblast Growth Factor 12B²
Fibroblast Growth Factor Homologous Factor 1² ³		Fibroblast Growth Factor FGF-12b²
Myocyte-Activating Factor² ³

External Ids:	HGNC: 3668¹	Entrez Gene: 2257²	Ensembl: ENSG00000114279⁷	OMIM: 601513⁵	UniProtKB: P61328³

Export aliases for FGF12 gene to outside databases

Previous GC identifers: GC03M188826 GC03M193121 GC03M193261 GC03M193180 GC03M193342 GC03M189260

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF12:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including

embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks

the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues

that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this

protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been

determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328

Function: Probably involved in nervous system development and function

Gene Wiki entry for FGF12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF12 gene promoter:
HFH-3 Sp1 GATA-1 C/EBPalpha Egr-2 FOXI1 AREB6 FAC1 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FGF12 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q28

FGF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF12 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M191859: view genomic region (about GC identifiers)

Start:	191,859,684 bp from pter	End:	192,485,553 bp from pter
Size:	625,870 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328 (See protein sequence)

Recommended Name: Fibroblast growth factor 12

Size: 243 amino acids; 27399 Da

Subunit: Interacts with the C-terminal region of SCN9A (By similarity)

Subcellular location: Nucleus (Probable)

1 PDB 3D structure from and Proteopedia for FGF12:

1Q1U (3D)

Secondary accessions: B2R6B7 B2R976 O35339 P70376 Q8TBG5 Q92912 Q93001

Alternative splicing: 2 isoforms: P61328-1 P61328-2

Explore the universe of human proteins at neXtProt for FGF12: NX_P61328

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61328

FGF12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004104.3 NP_066360.1

ENSEMBL proteins:

ENSP00000393686 ENSP00000413496 ENSP00000400948 ENSP00000397635 ENSP00000410125

ENSP00000412904 ENSP00000395517 ENSP00000264730

Human Recombinant Protein Products:

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	Novus Biologicals FGF12 Proteins Novus Biologicals FGF12 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FGF12
	Uscn Proteins for FGF12

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	10049777
GO:0005634	nucleus	IDA	8790420

FGF12 for ontologies About GeneDecksing

FGF12 Antibody Products:

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	Uscn ELISAs and CLIAs for FGF12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF12 for domains About GeneDecksing

3 InterPro domains/families:

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR002209 GF_heparin-bd

Graphical View of Domain Structure for InterPro Entry P61328

ProtoNet protein and cluster: P61328

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328

Function: Probably involved in nervous system development and function

Genatlas biochemistry entry for FGF12:

fibroblast growth homologous factor 12,expressed principally in the nervous system

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FGF12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF12
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF12 (see all 64):
		hsa-miR-142-5p hsa-miR-607 hsa-miR-19b-2* hsa-miR-429 hsa-miR-1224-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-1260b

		SwitchGear 3'UTR luciferase reporter plasmid: FGF12 3' UTR sequence

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGF12
		Search LifeMap BioReagents cell lines for FGF12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF12

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005104	NOT fibroblast growth factor receptor binding	IDA	12815063
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IDA	12815063

FGF12 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Fgf12^tm1Gol for FGF12
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fgf12):

behavior/neurological

nervous system

FGF12 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF12 (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for FGF12

Regulation of Actin Cytoskeleton

4 Kegg Pathways (Kegg details for FGF12):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF12 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FGF12

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for FGF12 (P61328³ ENSP00000413496⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK8IP2	Q13387³, ENSP00000330572⁴	I2D: score=2 STRING: ENSP00000330572
MAPK13	O15264³, ENSP00000211287⁴	I2D: score=1 STRING: ENSP00000211287
THAP1	Q9NVV9³	I2D: score=1
EGFR	ENSP00000275493⁴	STRING: ENSP00000275493
FGFR1	ENSP00000380280⁴	STRING: ENSP00000380280

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8790420
GO:0007254	JNK cascade	IPI	12815063
GO:0007267	cell-cell signaling	TAS	8790420
GO:0007268	synaptic transmission	IEA	--
GO:0007399	nervous system development	TAS	8790420

FGF12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF12
Search CenterWatch for drugs/clinical trials and news about FGF12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF12 gene (2 alternative transcripts):

NM_004113.5 NM_021032.4

Unigene Cluster for FGF12:

Fibroblast growth factor 12

Hs.390250 [show with all ESTs]

Unigene Representative Sequence: NM_021032

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000445105(uc003fsy.3) ENST00000454309(uc003fsx.3) ENST00000440901

ENST00000450716 ENST00000430714 ENST00000448795 ENST00000418610 ENST00000466144

ENST00000491636 ENST00000264730

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF12
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF12 (see all 64):
		hsa-miR-142-5p hsa-miR-607 hsa-miR-19b-2* hsa-miR-429 hsa-miR-1224-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-1260b

		SwitchGear 3'UTR luciferase reporter plasmid: FGF12 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF12

Additional cDNA sequence:

AK123610.1 AK125307.1 AK312513.1 AK313671.1 BC022524.1 U66197.1 U76381.2 Z70276.1

13 DOTS entries:

DT.455272 DT.95371016 DT.120928120 DT.446452 DT.120928142 DT.92433456 DT.97838610 DT.306832

DT.435560 DT.120928172 DT.92433451 DT.99964359 DT.120928158

24/125 AceView cDNA sequences (see all 125):

Z45931 Z44867 AI815912 AA131493 F06170 BQ955152 U66197 Z39575

AA365577 F06169 CB959964 AI928840 BM663783 BI494807 AW237589 BX410039

Z70276 BM927147 F01799 AA400007 CA390609 AW949462 BI522878 AI199217

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGCAAAGA

About this image

FGF12 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Ureteric Bud

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

See FGF12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF12

SOURCE GeneReport for Unigene cluster: Hs.390250

UniProtKB/Swiss-Prot: FGF12_HUMAN, P61328

Tissue specificity: Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb,

and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei,

cortex and multiple midbrain structures

SABiosciences Expression via Pathway-Focused PCR Arrays including FGF12:

Huntington's Disease in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FGF12 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGF12¹	fibroblast growth factor 12	89.85(n) 98.77(a)		395704 NM_204888.1 NP_990219.1
lizard (Anolis carolinensis)	Reptilia	FGF12⁶	--	97(a)	1 ↔ 1	GL343669.1(156659-286605)
African clawed frog (Xenopus laevis)	Amphibia	BX844224.1²	--	84.92(n)		BX844224.1
zebrafish (Danio rerio)	Actinopterygii	fgf12a¹	fibroblast growth factor 12a	79.44(n) 90.83(a)		777735 NM_001077782.1 NP_001071250.1
fruit fly (Drosophila melanogaster)	Insecta	bnl⁶	branchless	6(a)	1 → many	3R(15619795-15662539)

ENSEMBL Gene Tree for FGF12 (if available)
TreeFam Gene Tree for FGF12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF12 gene

FGF5² FGF20² FGF16² FGF4² FGF9² FGF6² FGF3² FGF7²

FGF11² FGF10² FGF22² FGF13² FGF14²

17 SIMAP similar genes for FGF12 using alignment to 6 protein entries: FGF12_HUMAN (see all proteins):

FGF13 FGF14 FGF11 FGF9 FGF16 KGFLP1

KGFLP2 FGF20 FGF22 FGF7 PRED3 FGF10

FGF1 FGF6 FGF4 fgf gene FGF2

FGF12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9836343^1,2	C,F,A,H,	unknown	191918451(+)	`ACTCCA/G/TTCAGT`	2	--	int¹		4		EA NS WA	416
rs112645915^1,2	C,	--	191856716(+)	`GCATTA/GTTTAT`	2	--	ds500¹		0	--	--	--	--
rs56285044^1,2	C	--	191856719(+)	`TATTT-/GTTT ATTTA`	2	--	ds500¹		1		NA	2
rs6774732^1,2	C,F,H,	--	191856805(+)	`TGGTAT/CGTTAT`	2	--	ds500¹		15		EA NS NA WA	1986
rs143527939^1,2		--	191856830(+)	`ATGAAC/TGTACT`	2	--	ds500¹		0	--	--	--	--
rs61242770^1,2	C,F,	--	191856866(+)	`ATGTCA/CGGTTG`	2	--	ds500¹		9		NA CSA WA EA	369
rs139614328^1,2		--	191856927(+)	`TTCTA-/CAAAAT`	2	--	ds500¹		0	--	--	--	--
rs115043911^1,2	F,	--	191856968(+)	`TTGATC/ATTTTT`	2	--	ds500¹		1		WA	118
rs71958722^1,2	C,	--	191856983(+)	`AAAAG-/ACACAGC`	2	--	ds500¹		0	--	--	--	--
rs61417328^1,2	C	--	191857020(+)	`AAAAAA/-GGTAG`	2	--	ds500¹		1		NA	2

HapMap Linkage Disequilibrium report for FGF12 (191859684 - 192109684 bp, first 250kb of FGF12)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for FGF12
15 CNVs: 2490 63696 63695 59121 68529 23234 63691 59120 36121 98575 63692 2062 0565 39353 98574
10 Indels: 80062 63694 91791 62140 80063 46360 27257 42414 80061 40590

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF12

DNA2.0 Custom Variant and Variant Library Synthesis for FGF12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGF12 for disorders           About GeneDecksing

OMIM gene information: 601513    OMIM disorders: --

10 diseases for FGF12:    About MalaCards

intracranial aneurysm esophageal squamous cell carcinoma squamous cell carcinoma huntington's disease

esophagitis carcinoma melanoma breast cancer

adenocarcinoma pancreatitis

Human Genome Epidemiology (HuGE) Navigator: FGF12 (4 documents)

Export disorders for FGF12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FGF12 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with FGF12)

Utopia: connect your pdf to the dynamic
world of online information

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)^{1, 2, 3} Smallwood P.M.... Nathans J. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart. (PubMed id 10049777)^{1, 2} Kok L.D.S....Fung K.-P. (1999)
Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization. (PubMed id 9345906)^{1, 3} Liu Y. and Chiu I.M. (1997)
Identification of novel DNA methylation markers in col orectal cancer using MIRA-based microarrays. (PubMed id 22552777)¹ Li H....Yang Y.X. (2012)
Fibroblast growth factor-12 (FGF12) translocation int o intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12. (PubMed id 21518765)¹ Nakayama F....Akashi M. (2011)
A pilot genome-wide association study shows genomic v ariants enriched in the non-tumor cells of patients with well-differentiated ne uroendocrine tumors of the ileum. (PubMed id 21139019)¹ Walsh K.M....Hoh J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2257	HGNC: 3668	AceView: FGF12	Ensembl:ENSG00000114279	euGenes: HUgn2257
ECgene: FGF12	Kegg: 2257	H-InvDB: FGF12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FGF12	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF12	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FGF12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FGF12 gene:
Search GeneIP for patents involving FGF12

GeneCards and IP:
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fibroblast growth factor 12

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fibroblast growth factor 12

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