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Aliases for FGF11 Gene

Aliases for FGF11 Gene

  • Fibroblast Growth Factor 11 2 3 5
  • Fibroblast Growth Factor Homologous Factor 3 2 3 4
  • FGF-11 3 4
  • FHF-3 3 4
  • FHF3 3 4

External Ids for FGF11 Gene

Previous GeneCards Identifiers for FGF11 Gene

  • GC17M007769
  • GC17P008072
  • GC17P007285
  • GC17P007544
  • GC17P007545
  • GC17P007283
  • GC17P007342
  • GC17P007343
  • GC17P007451
  • GC17P007462
  • GC17P007475
  • GC17P007510
  • GC17P007556
  • GC17P007611

Summaries for FGF11 Gene

Entrez Gene Summary for FGF11 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FGF11 Gene

FGF11 (Fibroblast Growth Factor 11) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Akt Signaling. GO annotations related to this gene include growth factor activity. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot for FGF11 Gene

  • Probably involved in nervous system development and function.

Additional gene information for FGF11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF11 Gene

Genomics for FGF11 Gene

Regulatory Elements for FGF11 Gene

Enhancers for FGF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007474 1.8 FANTOM5 ENCODE dbSUPER 25.7 +42.3 42317 12 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SSRP1 DVL2 PFAS SNORD10 POLR2A SNORA48 CTC1 KCTD11 NEURL4 CHRNB1 CNTROB
GH17H007465 1.3 Ensembl ENCODE dbSUPER 24.1 +28.8 28755 2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 CTBP1 NCOR1 RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 SPEM2 SPEM1 TNFSF12-TNFSF13 TNFSF12 TMEM256 NLGN2 PLSCR3
GH17H007454 1.2 ENCODE dbSUPER 16.3 +17.7 17708 2 HDGF PKNOX1 ATF1 SIN3A FEZF1 YY1 ETS1 ZNF766 GLIS2 ELK1 CHRNB1 FGF11 SPEM2 SPEM1 TNFSF12-TNFSF13 TNFSF12 TMEM256 NLGN2 PLSCR3 ACAP1
GH17H007439 1 ENCODE 18.6 +2.3 2298 2 HDGF PKNOX1 ARID4B GLI4 BRCA1 GLIS2 ZNF207 ATF7 ZNF548 RUNX3 DVL2 CTC1 PFAS SNORD10 CNTROB SNORA48 ENSG00000262089 CYB5D1 WRAP53 KCTD11
GH17H007470 0.5 dbSUPER 26.1 +32.7 32711 0 ZNF121 GATA3 HNF4A FGF11 CHRNB1 TMEM102 SPEM2 SPEM1 TNFSF12-TNFSF13 TNFSF12 TMEM256 NLGN2 PLSCR3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF11 on UCSC Golden Path with GeneCards custom track

Promoters for FGF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000282291 -1073 801 SIN3A GLIS2 ZNF143 ATF7 DEK REST ZNF592 SREBF1 GLIS1 NBN
ENSR00000090861 1827 201 ZBTB10 SP3 NFIB REST ZFHX2 NFIC KLF16 IKZF1 MXD3 ZNF207

Genomic Location for FGF11 Gene

Chromosome:
17
Start:
7,438,273 bp from pter
End:
7,444,937 bp from pter
Size:
6,665 bases
Orientation:
Plus strand

Genomic View for FGF11 Gene

Genes around FGF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF11 Gene

Proteins for FGF11 Gene

  • Protein details for FGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92914-FGF11_HUMAN
    Recommended name:
    Fibroblast growth factor 11
    Protein Accession:
    Q92914
    Secondary Accessions:
    • Q2YDX8

    Protein attributes for FGF11 Gene

    Size:
    225 amino acids
    Molecular mass:
    25005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGF11 Gene

Post-translational modifications for FGF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF11 Gene

No data available for DME Specific Peptides for FGF11 Gene

Domains & Families for FGF11 Gene

Gene Families for FGF11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FGF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q92914

UniProtKB/Swiss-Prot:

FGF11_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF11: view

Function for FGF11 Gene

Molecular function for FGF11 Gene

GENATLAS Biochemistry:
fibroblast growth homologous factor 11,expressed principally in the nervous system
UniProtKB/Swiss-Prot Function:
Probably involved in nervous system development and function.

Phenotypes From GWAS Catalog for FGF11 Gene

Gene Ontology (GO) - Molecular Function for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF11: view
genes like me logo Genes that share phenotypes with FGF11: view

Animal Models for FGF11 Gene

MGI Knock Outs for FGF11:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF11

CRISPR Products

miRNA for FGF11 Gene

miRTarBase miRNAs that target FGF11

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FGF11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF11 Gene

Localization for FGF11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF11 gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FGF11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FGF11 Gene

Pathways & Interactions for FGF11 Gene

genes like me logo Genes that share pathways with FGF11: view

Gene Ontology (GO) - Biological Process for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8790420
GO:0007267 cell-cell signaling TAS 8790420
GO:0007399 nervous system development TAS 8790420
genes like me logo Genes that share ontologies with FGF11: view

No data available for SIGNOR curated interactions for FGF11 Gene

Drugs & Compounds for FGF11 Gene

No Compound Related Data Available

Transcripts for FGF11 Gene

Unigene Clusters for FGF11 Gene

Fibroblast growth factor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FGF11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FGF11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: - -
SP8: -

Relevant External Links for FGF11 Gene

GeneLoc Exon Structure for
FGF11
ECgene alternative splicing isoforms for
FGF11

Expression for FGF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF11 Gene

This gene is overexpressed in Adrenal Gland (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF11 Gene



Protein tissue co-expression partners for FGF11 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF11 Gene:

FGF11

SOURCE GeneReport for Unigene cluster for FGF11 Gene:

Hs.655193

mRNA Expression by UniProt/SwissProt for FGF11 Gene:

Q92914-FGF11_HUMAN
Tissue specificity: Nervous system.

Evidence on tissue expression from TISSUES for FGF11 Gene

  • Nervous system(4.4)
  • Skin(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with FGF11: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF11 Gene

Orthologs for FGF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF11 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia FGF11 33 34
  • 95.11 (n)
dog
(Canis familiaris)
Mammalia FGF11 33 34
  • 94.22 (n)
rat
(Rattus norvegicus)
Mammalia Fgf11 33
  • 94.2 (n)
mouse
(Mus musculus)
Mammalia Fgf11 33 16 34
  • 94.05 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF11 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia FGF11 34
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgf11a 33 34
  • 68.04 (n)
fgf11b 34
  • 58 (a)
OneToMany
Species where no ortholog for FGF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF11 Gene

ENSEMBL:
Gene Tree for FGF11 (if available)
TreeFam:
Gene Tree for FGF11 (if available)

Paralogs for FGF11 Gene

Paralogs for FGF11 Gene

(16) SIMAP similar genes for FGF11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF11: view

Variants for FGF11 Gene

Sequence variations from dbSNP and Humsavar for FGF11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs138041351 Likely benign 7,445,295(+) GAGGG(C/T)CGACT downstream-variant-500B, reference, synonymous-codon
rs199903026 Uncertain significance 7,445,115(+) TGAGC(C/G/T)AGCCG downstream-variant-500B, utr-variant-5-prime
rs550926134 Uncertain significance 7,445,109(+) AGTCA(C/T)TGAGC downstream-variant-500B, utr-variant-5-prime
rs770468832 Uncertain significance 7,445,256(+) TTATT(C/T)TCTCC intron-variant, downstream-variant-500B
rs879255346 Uncertain significance 7,445,377(+) TCAGC(A/G)TTGGT downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FGF11 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for FGF11 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF11 Gene

Disorders for FGF11 Gene

Relevant External Links for FGF11

Human Genome Epidemiology (HuGE) Navigator
FGF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF11

No disorders were found for FGF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGF11 Gene

Publications for FGF11 Gene

  1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PMID: 8790420) Smallwood PM … Nathans J (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability. (PMID: 28027390) Lee KW … Jeong JY (FEBS letters 2016) 3 60
  4. Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma. (PMID: 27538493) Ye SB … Li J (The Journal of pathology 2016) 3 60
  5. Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling. (PMID: 25135278) Hu S … Chang C (Molecular oncology 2015) 3 60

Products for FGF11 Gene

Sources for FGF11 Gene

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