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Aliases for FGF11 Gene

Aliases for FGF11 Gene

  • Fibroblast Growth Factor 11 2 3
  • Fibroblast Growth Factor Homologous Factor 3 2 3 4
  • FHF3 3 4 6
  • FGF-11 3 4
  • FHF-3 3 4

External Ids for FGF11 Gene

Previous GeneCards Identifiers for FGF11 Gene

  • GC17M007769
  • GC17P008072
  • GC17P007285
  • GC17P007544
  • GC17P007545
  • GC17P007283
  • GC17P007342
  • GC17P007343

Summaries for FGF11 Gene

Entrez Gene Summary for FGF11 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FGF11 Gene

FGF11 (Fibroblast Growth Factor 11) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include growth factor activity. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF11 Gene

  • Probably involved in nervous system development and function

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF11 Gene

Genomics for FGF11 Gene

Regulatory Elements for FGF11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGF11 Gene

Start:
7,438,273 bp from pter
End:
7,444,937 bp from pter
Size:
6,665 bases
Orientation:
Plus strand

Genomic View for FGF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF11 Gene

Proteins for FGF11 Gene

  • Protein details for FGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92914-FGF11_HUMAN
    Recommended name:
    Fibroblast growth factor 11
    Protein Accession:
    Q92914
    Secondary Accessions:
    • Q2YDX8

    Protein attributes for FGF11 Gene

    Size:
    225 amino acids
    Molecular mass:
    25005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGF11 Gene

Proteomics data for FGF11 Gene at MOPED

Post-translational modifications for FGF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF11 Gene

No data available for DME Specific Peptides for FGF11 Gene

Domains for FGF11 Gene

Suggested Antigen Peptide Sequences for FGF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q92914

UniProtKB/Swiss-Prot:

FGF11_HUMAN :
  • Q92914
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF11: view

No data available for Gene Families for FGF11 Gene

Function for FGF11 Gene

Molecular function for FGF11 Gene

GENATLAS Biochemistry: fibroblast growth homologous factor 11,expressed principally in the nervous system
UniProtKB/Swiss-Prot Function: Probably involved in nervous system development and function

Gene Ontology (GO) - Molecular Function for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF11: view

Phenotypes for FGF11 Gene

genes like me logo Genes that share phenotypes with FGF11: view

Animal Model Products

CRISPR Products

miRNA for FGF11 Gene

miRTarBase miRNAs that target FGF11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGF11 Gene

Localization for FGF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF11 Gene COMPARTMENTS Subcellular localization image for FGF11 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FGF11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FGF11 Gene

Pathways for FGF11 Gene

genes like me logo Genes that share pathways with FGF11: view

Pathways by source for FGF11 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FGF11 Gene

Gene Ontology (GO) - Biological Process for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8790420
GO:0007267 cell-cell signaling TAS 8790420
GO:0007399 nervous system development TAS 8790420
genes like me logo Genes that share ontologies with FGF11: view

Transcripts for FGF11 Gene

Unigene Clusters for FGF11 Gene

Fibroblast growth factor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: - -
SP8: -

Relevant External Links for FGF11 Gene

GeneLoc Exon Structure for
FGF11
ECgene alternative splicing isoforms for
FGF11

Expression for FGF11 Gene

mRNA expression in normal human tissues for FGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF11 Gene

This gene is overexpressed in Adrenal Gland (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGF11 Gene

SOURCE GeneReport for Unigene cluster for FGF11 Gene Hs.655193

mRNA Expression by UniProt/SwissProt for FGF11 Gene

Q92914-FGF11_HUMAN
Tissue specificity: Nervous system
genes like me logo Genes that share expressions with FGF11: view

In Situ Assay Products

Orthologs for FGF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF11 35
  • 100 (n)
  • 100 (a)
FGF11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF11 35
  • 95.11 (n)
  • 97.78 (a)
FGF11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF11 35
  • 94.22 (n)
  • 97.78 (a)
FGF11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf11 35
  • 94.05 (n)
  • 97.32 (a)
Fgf11 16
Fgf11 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF11 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fgf11 35
  • 94.2 (n)
  • 96.87 (a)
lizard
(Anolis carolinensis)
Reptilia FGF11 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgf11a 35
  • 68.04 (n)
  • 68.49 (a)
fgf11a 36
  • 61 (a)
OneToMany
fgf11b 36
  • 58 (a)
OneToMany
Species with no ortholog for FGF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF11 Gene

ENSEMBL:
Gene Tree for FGF11 (if available)
TreeFam:
Gene Tree for FGF11 (if available)

Paralogs for FGF11 Gene

Paralogs for FGF11 Gene

Selected SIMAP similar genes for FGF11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF11: view

Variants for FGF11 Gene

Sequence variations from dbSNP and Humsavar for FGF11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3838886 -- 7,440,229(+) CCCCC(-/C)AGCCC intron-variant
rs3853818 -- 7,442,983(+) GAATG(C/T)ACGGG intron-variant
rs4151120 -- 7,438,829(+) TCCAG(A/T)CAACT upstream-variant-2KB
rs4151121 -- 7,438,975(+) TATCC(A/G)GCCAG upstream-variant-2KB
rs4151122 -- 7,439,363(+) CAAAA(C/T)TCGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FGF11 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907644 CNV Loss 21882294
nsv523672 CNV Loss 19592680
dgv3054n71 CNV Loss 21882294

Relevant External Links for FGF11 Gene

HapMap Linkage Disequilibrium report
FGF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF11 Gene

Disorders for FGF11 Gene

Relevant External Links for FGF11

Human Genome Epidemiology (HuGE) Navigator
FGF11
genes like me logo Genes that share disorders with FGF11: view

No data available for UniProtKB/Swiss-Prot for FGF11 Gene

Publications for FGF11 Gene

  1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PMID: 8790420) Smallwood P.M. … Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Roles of intracellular fibroblast growth factors in neural development and functions. (PMID: 23233218) Zhang X. … Li S. (Sci China Life Sci 2012) 3
  4. Chromosomal mapping of two novel human FGF genes, FGF11 and FGF12. (PMID: 9070933) Verdier A.S. … Coulier F. (Genomics 1997) 3
  5. Physical map of 17p13 and the genes adjacent to p53. (PMID: 10662545) Cousin P. … Shaw P. (Genomics 2000) 3

Products for FGF11 Gene

Sources for FGF11 Gene

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