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FGF11 Gene

protein-coding   GIFtS: 54
GCID: GC17P007343

Fibroblast Growth Factor 11

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 111 2
Fibroblast Growth Factor Homologous Factor 31 2 3
FHF32 3 5
FGF-112 3
FHF-32 3

External Ids:    HGNC: 36671   Entrez Gene: 22562   Ensembl: ENSG000001619587   OMIM: 6015145   UniProtKB: Q929143   

Export aliases for FGF11 gene to outside databases

Previous GC identifers: GC17M007769 GC17P008072 GC17P007285 GC17P007544 GC17P007545 GC17P007283 GC17P007342


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF11 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The
function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in
nervous system development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF11 Gene:
FGF11 (fibroblast growth factor 11) is a protein-coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF11_HUMAN, Q92914
Function: Probably involved in nervous system development and function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF11 gene promoter:
         Pax-5   CUTL1   Tal-1beta   POU3F2   C/EBPalpha   GATA-1   GATA-2   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FGF11 promoter sequence
   Search Chromatin IP Primers for FGF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

FGF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007343:  view genomic region     (about GC identifiers)

Start:
7,341,592 bp from pter      End:
7,348,256 bp from pter
Size:
6,665 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF11_HUMAN, Q92914 (See protein sequence)
Recommended Name: Fibroblast growth factor 11  
Size: 225 amino acids; 25005 Da
Secondary accessions: Q2YDX8

Explore the universe of human proteins at neXtProt for FGF11: NX_Q92914

Explore proteomics data for FGF11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004103.1  
    ENSEMBL proteins: 
     ENSP00000459746   ENSP00000293829   ENSP00000465134   ENSP00000460753   ENSP00000461397  

    FGF11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FGF11
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FGF11
    GenScript Custom Purified and Recombinant Proteins Services for FGF11
    Novus Biologicals FGF11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FGF11

     
    Search eBioscience for Proteins for FGF11 

     
    antibodies-online proteins for FGF11 (3 products) 

     
    antibodies-online peptides for FGF11

    FGF11 Antibody Products:

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    Novus Biologicals FGF11 Antibodies
    Abcam antibodies for FGF11
    Cloud-Clone Corp. Antibodies for FGF11
    Search ThermoFisher Antibodies for FGF11
    antibodies-online antibodies for FGF11 (26 products) 

    FGF11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF11
    Cloud-Clone Corp. CLIAs for FGF11
    Search eBioscience for ELISAs for FGF11 
    antibodies-online kits for FGF11 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028253 FGF11
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry Q92914

    ProtoNet protein and cluster: Q92914

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF11_HUMAN, Q92914
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF11_HUMAN, Q92914
    Function: Probably involved in nervous system development and function

         Genatlas biochemistry entry for FGF11:
    fibroblast growth homologous factor 11,expressed principally in the nervous system

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with FGF11           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf11):
     behavior/neurological  integument  vision/eye 

    Find genes that share phenotypes with FGF11           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FGF11

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGF11:
    hsa-mir-18a-3p (MIRT040846), hsa-mir-193b-3p (MIRT041432), hsa-mir-335-5p (MIRT018154)

    Block miRNA regulation of human, mouse, rat FGF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF11 (see all 28):
    hsa-miR-644 hsa-miR-328 hsa-miR-137 hsa-let-7d hsa-miR-330-5p hsa-miR-202 hsa-miR-331-3p hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidFGF11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF11
    Predesigned siRNA for gene silencing in human, mouse, rat FGF11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF11

    Clone
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    OriGene clones in human, mouse for FGF11 (see all 7)
    OriGene ORF clones in mouse, rat for FGF11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF11 (NM_004112)
    Sino Biological Human cDNA Clone for FGF11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF11

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FGF11
    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    Find genes that share ontologies with FGF11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF11 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with FGF11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF11 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF11
        Regulation of Actin Cytoskeleton



    Selected Kegg Pathways  (Kegg details for FGF11) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF11: 
              Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FGF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FGF11 (ENSP000002938294) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRENSP000002754934STRING: ENSP00000275493
    FGFR1ENSP000003802804STRING: ENSP00000380280
    FGFR2ENSP000004102944STRING: ENSP00000410294
    FGFR3ENSP000002607954STRING: ENSP00000260795
    FGFR4ENSP000002924084STRING: ENSP00000292408
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8790420
    GO:0007267cell-cell signaling TAS8790420
    GO:0007399nervous system development TAS8790420

    Find genes that share ontologies with FGF11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF11 gene: 
    NM_004112.2  

    Unigene Cluster for FGF11:

    Fibroblast growth factor 11
    Hs.655193  [show with all ESTs]
    Unigene Representative Sequence: BC032502
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575235(uc010cmh.1) ENST00000293829(uc010cmi.3 uc002ggz.3)
    ENST00000572907 ENST00000575398 ENST00000575082 ENST00000576328
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FGF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF11 (see all 28):
    hsa-miR-644 hsa-miR-328 hsa-miR-137 hsa-let-7d hsa-miR-330-5p hsa-miR-202 hsa-miR-331-3p hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidFGF11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FGF11
    Predesigned siRNA for gene silencing in human, mouse, rat FGF11
    Clone
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    OriGene clones in human, mouse for FGF11 (see all 7)
    OriGene ORF clones in mouse, rat for FGF11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF11 (NM_004112)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF11
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FGF11
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF11
      QuantiTect SYBR Green Assays in human, mouse, rat FGF11
      QuantiFast Probe-based Assays in human, mouse, rat FGF11

    Additional mRNA sequence: 

    AK293131.1 AK308477.1 AK308812.1 AK311269.1 AY049782.1 BC032502.1 BC037421.1 BC108265.1 
    U66199.1 Z70275.1 

    7 DOTS entries:

    DT.99973688  DT.312865  DT.100681637  DT.120899090  DT.97809630  DT.101962385  DT.91802269 

    Selected AceView cDNA sequences (see all 92):

    BM677432 BG697406 F03722 U66199 BM670363 BM745211 BG472308 CA423112 
    BM740406 CD514261 AL519512 BC032502 Z70275 BU736684 BX115539 BE222979 
    NM_004112 CR597907 AA601951 BM553166 T16627 T15934 BM783551 BC033882 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGF11 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:              -     -     -     -                       -     -                                       
    SP2:                          -     -                       -     -                                       
    SP3:        -     -     -     -     -                       -                                             
    SP4:        -     -     -     -     -                       -     -                                       
    SP5:                                                        -                                             


    ECgene alternative splicing isoforms for FGF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACTTAGC
    FGF11 Expression
    About this image


    FGF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
    FGF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655193

    UniProtKB/Swiss-Prot: FGF11_HUMAN, Q92914
    Tissue specificity: Nervous system

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF11: 
              Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FGF11
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF11
    QuantiTect SYBR Green Assays in human, mouse, rat FGF11
    QuantiFast Probe-based Assays in human, mouse, rat FGF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF11 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf111 , 5 fibroblast growth factor 111, 5 94.05(n)1
    97.32(a)1
      11 (42.88 cM)5
    141661  NM_010198.11  NP_034328.11 
     697960685 
    lizard
    (Anolis carolinensis)
    Reptilia FGF116
    fibroblast growth factor 11
    79(a)
    1 ↔ 1
    AAWZ02036351(6427-25727)
    zebrafish
    (Danio rerio)
    Actinopterygii fgf11a1 fibroblast growth factor 11a 68.04(n)
    68.49(a)
      497640  NM_001012380.1  NP_001012380.1 


    ENSEMBL Gene Tree for FGF11 (if available)
    TreeFam Gene Tree for FGF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF11 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
    FGF72  FGF102  FGF132  FGF222  FGF142  
    16 SIMAP similar genes for FGF11 using alignment to 3 protein entries:     FGF11_HUMAN (see all proteins):
    FGF12    FGF13    FGF14    KGFLP1    FGF16    FGF9
    KGFLP2    FGF10    FGF7    PRED3    FGF20    FGF5
    FGF22    FGF1    FGF4    FGF8

    Find genes that share paralogs with FGF11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF11 (see all 124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891899331,2
    --7341645(+) CCGCTG/TCCGCC 1 -- us2k10--------
    rs1815733531,2
    --7341760(+) GGCGTC/GGGGGG 1 -- us2k10--------
    rs1856750961,2
    --7341894(+) GCAATC/GCCGGG 1 -- us2k10--------
    rs1153791261,2
    F--7341902(+) GGGGAG/AGACGA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs41511201,2
    C,F,A,H--7342148(+) TCCAGT/ACAACT 1 -- us2k119Minor allele frequency- A:0.24NS EA WA NA CSA 1474
    rs1446467001,2
    --7342156(+) ACTACC/GTGGTG 1 -- us2k10--------
    rs1902203221,2
    --7342231(+) AAGGGG/TCTTGG 1 -- us2k10--------
    rs1484774521,2
    C--7342246(+) TAGAAC/TTCTAT 1 -- us2k10--------
    rs41511211,2
    C,F,A,H--7342294(+) TATCCA/GGCCAG 1 -- us2k127Minor allele frequency- G:0.24NS EA WA NA CSA 2894
    rs1426309171,2
    --7342312(+) GGGAGC/TCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGF11 (7341592 - 7348256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FGF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    dgv3054n71CNV Loss21882294
    nsv907644CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601514    OMIM disorders: --


    Find genes that share disorders with FGF11           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: FGF11 (1 document)

    Export disorders for FGF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FGF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PubMed id 15199049)1 Popovici C....Roubin R. (J. Biol. Chem. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Physical map of 17p13 and the genes adjacent to p53. (PubMed id 10662545)1 Cousin P....Shaw P. (Genomics 2000)
    7. Chromosomal mapping of two novel human FGF genes, FGF11 and FGF12. (PubMed id 9070933)1 Verdier A.S....Coulier F. (Genomics 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2256 HGNC: 3667 AceView: FGF11 Ensembl:ENSG00000161958 euGenes: HUgn2256
    ECgene: FGF11 Kegg: 2256 H-InvDB: FGF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF11 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF11 gene:
    Search GeneIP for patents involving FGF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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