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Aliases for FGF11 Gene

Aliases for FGF11 Gene

  • Fibroblast Growth Factor 11 2 3 5
  • Fibroblast Growth Factor Homologous Factor 3 2 3 4
  • FGF-11 3 4
  • FHF-3 3 4
  • FHF3 3 4

External Ids for FGF11 Gene

Previous GeneCards Identifiers for FGF11 Gene

  • GC17M007769
  • GC17P008072
  • GC17P007285
  • GC17P007544
  • GC17P007545
  • GC17P007283
  • GC17P007342
  • GC17P007343
  • GC17P007451
  • GC17P007462

Summaries for FGF11 Gene

Entrez Gene Summary for FGF11 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FGF11 Gene

FGF11 (Fibroblast Growth Factor 11) is a Protein Coding gene. Among its related pathways are Glioma and p70S6K Signaling. GO annotations related to this gene include growth factor activity. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF11 Gene

  • Probably involved in nervous system development and function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF11 Gene

Genomics for FGF11 Gene

Regulatory Elements for FGF11 Gene

Enhancers for FGF11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGF11 on UCSC Golden Path with GeneCards custom track

Promoters for FGF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGF11 Gene

Chromosome:
17
Start:
7,438,273 bp from pter
End:
7,444,937 bp from pter
Size:
6,665 bases
Orientation:
Plus strand

Genomic View for FGF11 Gene

Genes around FGF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF11 Gene

Proteins for FGF11 Gene

  • Protein details for FGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92914-FGF11_HUMAN
    Recommended name:
    Fibroblast growth factor 11
    Protein Accession:
    Q92914
    Secondary Accessions:
    • Q2YDX8

    Protein attributes for FGF11 Gene

    Size:
    225 amino acids
    Molecular mass:
    25005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGF11 Gene

Proteomics data for FGF11 Gene at MOPED

Post-translational modifications for FGF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF11 Gene

Antibody Products

No data available for DME Specific Peptides for FGF11 Gene

Domains & Families for FGF11 Gene

Suggested Antigen Peptide Sequences for FGF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q92914

UniProtKB/Swiss-Prot:

FGF11_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF11: view

No data available for Gene Families for FGF11 Gene

Function for FGF11 Gene

Molecular function for FGF11 Gene

GENATLAS Biochemistry:
fibroblast growth homologous factor 11,expressed principally in the nervous system
UniProtKB/Swiss-Prot Function:
Probably involved in nervous system development and function.
genes like me logo Genes that share phenotypes with FGF11: view

Animal Models for FGF11 Gene

MGI Knock Outs for FGF11:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF11

miRNA for FGF11 Gene

miRTarBase miRNAs that target FGF11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF11 Gene

Localization for FGF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF11 Gene COMPARTMENTS Subcellular localization image for FGF11 gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FGF11 Gene

Pathways & Interactions for FGF11 Gene

genes like me logo Genes that share pathways with FGF11: view

Interacting Proteins for FGF11 Gene

Gene Ontology (GO) - Biological Process for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 8790420
GO:0007399 nervous system development TAS 8790420
genes like me logo Genes that share ontologies with FGF11: view

No data available for SIGNOR curated interactions for FGF11 Gene

Drugs & Compounds for FGF11 Gene

No Compound Related Data Available

Transcripts for FGF11 Gene

Unigene Clusters for FGF11 Gene

Fibroblast growth factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: - -
SP8: -

Relevant External Links for FGF11 Gene

GeneLoc Exon Structure for
FGF11
ECgene alternative splicing isoforms for
FGF11

Expression for FGF11 Gene

mRNA expression in normal human tissues for FGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF11 Gene

This gene is overexpressed in Adrenal Gland (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF11 Gene



SOURCE GeneReport for Unigene cluster for FGF11 Gene Hs.655193

mRNA Expression by UniProt/SwissProt for FGF11 Gene

Q92914-FGF11_HUMAN
Tissue specificity: Nervous system.
genes like me logo Genes that share expression patterns with FGF11: view

Protein tissue co-expression partners for FGF11 Gene

Primer Products

No data available for Protein differential expression in normal tissues for FGF11 Gene

Orthologs for FGF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF11 35
  • 95.11 (n)
  • 97.78 (a)
FGF11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF11 35
  • 94.22 (n)
  • 97.78 (a)
FGF11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf11 35
  • 94.05 (n)
  • 97.32 (a)
Fgf11 16
Fgf11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF11 35
  • 100 (n)
  • 100 (a)
FGF11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf11 35
  • 94.2 (n)
  • 96.87 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF11 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia FGF11 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgf11a 35
  • 68.04 (n)
  • 68.49 (a)
fgf11a 36
  • 61 (a)
OneToMany
fgf11b 36
  • 58 (a)
OneToMany
Species with no ortholog for FGF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF11 Gene

ENSEMBL:
Gene Tree for FGF11 (if available)
TreeFam:
Gene Tree for FGF11 (if available)

Paralogs for FGF11 Gene

Paralogs for FGF11 Gene

(16) SIMAP similar genes for FGF11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF11: view

Variants for FGF11 Gene

Sequence variations from dbSNP and Humsavar for FGF11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_018886 -
rs4151120 -- 7,438,829(+) TCCAG(A/T)CAACT intron-variant, upstream-variant-2KB
rs4151121 -- 7,438,975(+) TATCC(A/G)GCCAG intron-variant, upstream-variant-2KB
rs4151122 -- 7,439,363(+) CAAAA(C/T)TCGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs4151123 -- 7,439,384(+) ACTGA(C/G)GAGTA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FGF11 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907644 CNV Loss 21882294
nsv523672 CNV Loss 19592680
dgv3054n71 CNV Loss 21882294

Variation tolerance for FGF11 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FGF11 Gene

Disorders for FGF11 Gene

Relevant External Links for FGF11

Human Genome Epidemiology (HuGE) Navigator
FGF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF11

No disorders were found for FGF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGF11 Gene

Publications for FGF11 Gene

  1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PMID: 8790420) Smallwood P.M. … Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 67
  2. Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11a89miRNA-541a89androgen receptor (AR)a89MMP9 signaling. (PMID: 25135278) Hu S. … Chang C. (Mol Oncol 2015) 3
  3. Roles of intracellular fibroblast growth factors in neural development and functions. (PMID: 23233218) Zhang X. … Li S. (Sci China Life Sci 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PMID: 15199049) Popovici C. … Roubin R. (J. Biol. Chem. 2004) 3

Products for FGF11 Gene

Sources for FGF11 Gene

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