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Aliases for FGF10 Gene

Aliases for FGF10 Gene

  • Fibroblast Growth Factor 10 2 3
  • Keratinocyte Growth Factor 2 3 4
  • FGF-10 3 4
  • Produced By Fibroblasts Of Urinary Bladder Lamina Propria 3

External Ids for FGF10 Gene

Previous GeneCards Identifiers for FGF10 Gene

  • GC05M044614
  • GC05M045481
  • GC05M044305
  • GC05M044350

Summaries for FGF10 Gene

Entrez Gene Summary for FGF10 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF10 Gene

FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include aplasia of lacrimal and salivary glands and fgf10-related lacrimo-auriculo-dento-digital syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF10 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Gene Wiki entry for FGF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF10 Gene

Genomics for FGF10 Gene

Regulatory Elements for FGF10 Gene

Genomic Location for FGF10 Gene

Chromosome:
5
Start:
44,303,541 bp from pter
End:
44,389,780 bp from pter
Size:
86,240 bases
Orientation:
Minus strand

Genomic View for FGF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FGF10 Gene

Proteins for FGF10 Gene

  • Protein details for FGF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15520-FGF10_HUMAN
    Recommended name:
    Fibroblast growth factor 10
    Protein Accession:
    O15520
    Secondary Accessions:
    • C7FDY0
    • Q6FHR3
    • Q6FHT6
    • Q96P59

    Protein attributes for FGF10 Gene

    Size:
    208 amino acids
    Molecular mass:
    23436 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

    Three dimensional structures from OCA and Proteopedia for FGF10 Gene

neXtProt entry for FGF10 Gene

Proteomics data for FGF10 Gene at MOPED

Post-translational modifications for FGF10 Gene

  • Glycosylation at Asn 51 and Asn 196
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF10 Gene

Domains & Families for FGF10 Gene

Graphical View of Domain Structure for InterPro Entry

O15520

UniProtKB/Swiss-Prot:

FGF10_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF10: view

No data available for Gene Families for FGF10 Gene

Function for FGF10 Gene

Molecular function for FGF10 Gene

GENATLAS Biochemistry:
fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

LifeMap Function Summary for FGF10 Gene

Gene Ontology (GO) - Molecular Function for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IDA 11923311
GO:0005111 type 2 fibroblast growth factor receptor binding IPI 19224135
GO:0005515 protein binding IPI 12591959
GO:0008083 growth factor activity IDA 11923311
GO:0008201 heparin binding IDA 11923311
genes like me logo Genes that share ontologies with FGF10: view
genes like me logo Genes that share phenotypes with FGF10: view

Animal Models for FGF10 Gene

MGI Knock Outs for FGF10:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF10 Gene

Localization for FGF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF10 Gene COMPARTMENTS Subcellular localization image for FGF10 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16597614
GO:0005634 nucleus IDA 11923311
GO:0005886 plasma membrane IDA 16597614
GO:0009986 cell surface NAS 11923311
genes like me logo Genes that share ontologies with FGF10: view

Pathways & Interactions for FGF10 Gene

SuperPathways for FGF10 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K/AKT Signaling in Cancer
4 GPCR Pathway
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with FGF10: view

PCR Array Products

SIGNOR curated interactions for FGF10 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity IDA 14975937
GO:0001525 angiogenesis IEA --
genes like me logo Genes that share ontologies with FGF10: view

Drugs & Compounds for FGF10 Gene

(4) Drugs for FGF10 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
bromodeoxyuridine Pharma 4
tyrosine Nutra 547

(4) Additional Compounds for FGF10 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dextran sulfate sodium
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
9050-30-0
retinoic acid
302-79-4
VEGF
genes like me logo Genes that share compounds with FGF10: view

Transcripts for FGF10 Gene

mRNA/cDNA for FGF10 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF10 Gene

Fibroblast growth factor 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF10 Gene

No ASD Table

Relevant External Links for FGF10 Gene

GeneLoc Exon Structure for
FGF10
ECgene alternative splicing isoforms for
FGF10

Expression for FGF10 Gene

mRNA expression in normal human tissues for FGF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF10 Gene

This gene is overexpressed in Cervix - Endocervix (x5.6), Cervix - Ectocervix (x5.2), Adipose - Visceral (Omentum) (x4.8), and Breast - Mammary Tissue (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF10 Gene



SOURCE GeneReport for Unigene cluster for FGF10 Gene Hs.664499

genes like me logo Genes that share expression patterns with FGF10: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FGF10 Gene

Orthologs for FGF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF10 35
  • 93.37 (n)
  • 96.12 (a)
dog
(Canis familiaris)
Mammalia FGF10 35
  • 94.36 (n)
  • 96.62 (a)
FGF10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf10 35
  • 90.5 (n)
  • 90.82 (a)
Fgf10 16
Fgf10 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF10 35
  • 99.84 (n)
  • 100 (a)
FGF10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf10 35
  • 92.11 (n)
  • 97.1 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF10 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF10 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF10 35
  • 83.58 (n)
  • 87.32 (a)
FGF10 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf10 35
  • 76.63 (n)
  • 77.32 (a)
Str.15379 35
African clawed frog
(Xenopus laevis)
Amphibia fgf10-A 35
zebrafish
(Danio rerio)
Actinopterygii fgf10 35
fgf10b 35
  • 62.83 (n)
  • 60 (a)
fgf10a 36
  • 55 (a)
OneToMany
fgf10b 36
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 36
  • 19 (a)
OneToMany
Species with no ortholog for FGF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF10 Gene

ENSEMBL:
Gene Tree for FGF10 (if available)
TreeFam:
Gene Tree for FGF10 (if available)

Paralogs for FGF10 Gene

Paralogs for FGF10 Gene

genes like me logo Genes that share paralogs with FGF10: view

Variants for FGF10 Gene

Sequence variations from dbSNP and Humsavar for FGF10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_029888 Lacrimo-auriculo-dento-digital syndrome (LADDS)
VAR_029889 Lacrimo-auriculo-dento-digital syndrome (LADDS)

Structural Variations from Database of Genomic Variants (DGV) for FGF10 Gene

Variant ID Type Subtype PubMed ID
nsv4816 CNV Loss 18451855
esv2677507 CNV Deletion 23128226
nsv830277 CNV Gain 17160897

Variation tolerance for FGF10 Gene

Residual Variation Intolerance Score: 52.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF10 Gene

HapMap Linkage Disequilibrium report
FGF10
Human Gene Mutation Database (HGMD)
FGF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF10 Gene

Disorders for FGF10 Gene

MalaCards: The human disease database

(22) MalaCards diseases for FGF10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
aplasia of lacrimal and salivary glands
  • absence of salivary glands
fgf10-related lacrimo-auriculo-dento-digital syndrome
ladd syndrome
  • lacrimoauriculodentodigital syndrome
mesenteric vascular occlusion
clear cell acanthoma
  • pale acanthoma
- elite association
Search FGF10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF10_HUMAN
  • Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269 PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269 PubMed:16501574, ECO:0000269 PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF10

Genetic Association Database (GAD)
FGF10
Human Genome Epidemiology (HuGE) Navigator
FGF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF10
genes like me logo Genes that share disorders with FGF10: view

No data available for Genatlas for FGF10 Gene

Publications for FGF10 Gene

  1. Structure and expression of human fibroblast growth factor-10. (PMID: 9287324) Emoto H. … Itoh N. (J. Biol. Chem. 1997) 2 23 67
  2. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. (PMID: 20301097) Touboul T. … Vallier L. (Hepatology 2010) 23 67
  3. Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10. (PMID: 19969077) Kobberup S. … Jensen J. (Mech. Dev. 2010) 23 67
  4. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. (PMID: 20035084) Watanabe Y. … Buckingham M.E. (Circ. Res. 2010) 23 67
  5. Postnatal development of the lamina reticularis in primate airways. (PMID: 20503389) Evans M.J. … Hyde D.M. (Anat Rec (Hoboken) 2010) 23 67

Products for FGF10 Gene

Sources for FGF10 Gene

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