Aliases for FGF10 Gene
Aliases for FGF10 Gene
External Ids for FGF10 Gene
- HGNC: 3666
- Entrez Gene: 2255
- Ensembl: ENSG00000070193
- OMIM: 602115
- UniProtKB: O15520
Previous GeneCards Identifiers for FGF10 Gene
- GC05M044614
- GC05M045481
- GC05M044305
- GC05M044350
Summaries for FGF10 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF10 Gene
FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include Aplasia Of Lacrimal And Salivary Glands and Ladd Syndrome. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF7.
UniProtKB/Swiss-Prot for FGF10 Gene
-
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF10 Gene
Genomics for FGF10 Gene
Regulatory Elements for FGF10 Gene
Enhancers for FGF10 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G044603 | 0.4 | ENCODE | 10.7 | -213.9 | -213874 | 0.2 | CTCF | FGF10 FGF10-AS1 GC05P044546 LINC02224 |
| GH05G044387 | 1.4 | VISTA Ensembl ENCODE | 0.7 | +0.6 | 640 | 2.5 | SUZ12 CHD1 CBX2 RBBP5 REST ZFHX2 PRDM10 PRDM1 EZH2 EGR2 | FGF10 FGF10-AS1 |
| GH05G044405 | 0.3 | FANTOM5 | 0.4 | -16.2 | -16162 | 0.1 | FGF10 GC05P044486 | |
| GH05G044483 | 0.3 | FANTOM5 | 0.2 | -93.4 | -93440 | 0.3 | ENSG00000272335 GC05P044486 FGF10 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGF10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FGF10 gene promoter:
Regulatory Element Products
Genomic Location for FGF10 Gene
- Chromosome:
- 5
- Start:
- 44,303,541 bp from pter
- End:
- 44,389,780 bp from pter
- Size:
- 86,240 bases
- Orientation:
- Minus strand
Genomic View for FGF10 Gene
Genes around FGF10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p12 by Ensembl
- 5p12 by Entrez Gene
- 5p12 by HGNC
FGF10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF10 Gene
Proteins for FGF10 Gene
-
Protein details for FGF10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15520-FGF10_HUMAN
- Recommended name:
- Fibroblast growth factor 10
- Protein Accession:
- O15520
- C7FDY0
- Q6FHR3
- Q6FHT6
- Q96P59
Protein attributes for FGF10 Gene
- Size:
- 208 amino acids
- Molecular mass:
- 23436 Da
- Quaternary structure:
-
- Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.
Protein Expression for FGF10 Gene
Post-translational modifications for FGF10 Gene
Other Protein References for FGF10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FGF10
- R&D Systems Antibodies for FGF10 (FGF-10)
-
Custom Antibody ServicesOriGene Antibodies for FGF10
- Novus Biologicals Antibodies for FGF10
-
Cloud-Clone Corp. Antibodies for FGF10
- Invitrogen Antibodies for FGF10
- antibodies-online Antibodies for FGF10: See all 98
- GeneTex FGF10 antibody for FGF10
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF10
Protein Products
- EMD Millipore Purified and/or Recombinant FGF10 Protein
- R&D Systems Proteins and Enzymes for FGF10 (FGF-10)
-
OriGene Purified Proteins for FGF10
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF10
- Origene Custom Protein Services for FGF10
- Sino Biological Recombinant Proteins for FGF10
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for FGF10
-
Cloud-Clone Corp. Proteins for FGF10
- antibodies-online Proteins for FGF10: See all 70
- Search antibodies-online for peptides
- GeneTex Proteins for FGF10
-
ProSci Proteins for FGF10
Assay Products
- antibodies-online Kits for FGF10: See all 39
No data available for DME Specific Peptides for FGF10 Gene
Domains & Families for FGF10 Gene
Protein Domains for FGF10 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15520- Family:
-
- Belongs to the heparin-binding growth factors family.
No data available for Gene Families for FGF10 Gene
Function for FGF10 Gene
Molecular function for FGF10 Gene
- GENATLAS Biochemistry:
- fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
LifeMap Function Summary for FGF10 Gene
During embryonic development, FGF10 as signaling molecule is secreted from the following cells
- Head Mesenchyme
- Lung
- Pancreas
- Liver
- Lateral Plate Mesoderm
- Kidney
- Limb
It affects the following cells:
- Limb
- Epidermis
- Lung
- Liver
- Gut Tube
- Pancreas
- Tooth
- Kidney
FGF10 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Liver
- Pancreas
- Endoderm
- Lung
-
and also in
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005104 | fibroblast growth factor receptor binding | IEA,IDA | 11923311 |
| GO:0005111 | type 2 fibroblast growth factor receptor binding | IPI | 19224135 |
| GO:0005515 | protein binding | IPI | 12591959 |
Phenotypes for FGF10 Gene
- MGI mutant phenotypes for FGF10:
-
inferred from 10 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for FGF10:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased circadian period length
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Decreased viability after ionizing radiation
Animal Models for FGF10 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FGF10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF10 gene
- Search ViGene Biosciences for FGF10
CRISPR Products
-
OriGene CRISPR knockouts for FGF10
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF10
- GenScript: Design CRISPR guide RNA sequences for FGF10
miRNA for FGF10 Gene
- miRTarBase miRNAs that target FGF10
-
- hsa-mir-335-5p (MIRT018544)
- hsa-mir-335-3p (MIRT616818)
- hsa-mir-1305 (MIRT616819)
- hsa-mir-607 (MIRT616820)
- hsa-mir-3671 (MIRT616821)
- hsa-mir-1283 (MIRT616822)
- hsa-mir-7705 (MIRT623946)
- hsa-mir-186-3p (MIRT628221)
- hsa-mir-4705 (MIRT628222)
- hsa-mir-4762-5p (MIRT628223)
- hsa-mir-7152-5p (MIRT633891)
- hsa-mir-511-5p (MIRT633892)
- hsa-mir-502-5p (MIRT633893)
- hsa-mir-6830-3p (MIRT633894)
- hsa-mir-7162-5p (MIRT633895)
- hsa-mir-516b-3p (MIRT633896)
- hsa-mir-516a-3p (MIRT633897)
- hsa-mir-2115-5p (MIRT633898)
- hsa-mir-6841-3p (MIRT633899)
- hsa-mir-5699-3p (MIRT633900)
- hsa-mir-4421 (MIRT633901)
- hsa-mir-6748-3p (MIRT633902)
- hsa-mir-6826-5p (MIRT638733)
- hsa-mir-216b-5p (MIRT658151)
- hsa-mir-3977 (MIRT668357)
- hsa-mir-1915-5p (MIRT668358)
miRNA Products
- Search ViGene Biosciences for FGF10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGF10
- Browse OriGene Inhibitory RNA Products For FGF10
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF10 gene
Clone Products
-
OriGene ORF clones in human for FGF10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGF10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FGF10
-
ViGene Biosciences adenoviral particle packaged cDNA for FGF10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGF10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF10 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF10 Gene
Localization for FGF10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF10 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005615 | extracellular space | IDA | 16597614 |
| GO:0005634 | nucleus | IDA | 11923311 |
| GO:0005886 | plasma membrane | IDA | 16597614 |
| GO:0009986 | cell surface | NAS | 11923311 |
Pathways & Interactions for FGF10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 3 | Downstream signaling of activated FGFR2 | ||
| 4 | GPCR Pathway |
.73
.62
|
.55
|
| 5 | GAB1 signalosome |
.89
|
|
Pathways by source for FGF10 Gene
3 BioSystems pathways for FGF10 Gene
86 Reactome pathways for FGF10 Gene
8 KEGG pathways for FGF10 Gene
1 GeneGo (Thomson Reuters) pathway for FGF10 Gene
4 R&D Systems pathways for FGF10 Gene
- Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
- Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
- Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers
- Neural Stem Cell Differentiation Pathways and Lineage-specific Markers
Interacting Proteins for FGF10 Gene
Selected Interacting proteins:
ENSP00000264664
O15520-FGF10_HUMAN
for FGF10 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000132 | establishment of mitotic spindle orientation | IEA | -- |
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | IDA | 14975937 |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001656 | metanephros development | IEP | 18437684 |
Transcripts for FGF10 Gene
mRNA/cDNA for FGF10 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (16) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGF10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGF10
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF10
- GenScript: Design CRISPR guide RNA sequences for FGF10
miRNA Products
- Search ViGene Biosciences for FGF10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGF10
- Browse OriGene Inhibitory RNA Products For FGF10
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF10 gene
Clone Products
-
OriGene ORF clones in human for FGF10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGF10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FGF10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Adipose (Muscoskeletal System)
- Subcutaneous White Preadipocytes Subcutaneous White Adipose
- Subcutaneous White Preadipocytes Facial Subcutaneous White Adipose
- Visceral White Preadipocytes Visceral White Adipose
- Stromal Vascular Preadipocyte Progenitor Cells Vascular Adipose
- Subcutaneous White Preadipocytes Cranial Subcutaneous White Adipose
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Limb Bud Mesenchyme Cells Limb Bud
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
-
Lung (Respiratory System)
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Distal Mesodermal Progenitor Cells Lung Mesoderm
- Lung Mesoderm
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Odontoblasts Dentin
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Heart (Cardiovascular System)
- Heart Tube Cells Heart Tube
- Cardiac progenitor cells (Sca1+)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Metanephros
-
Surface Ectoderm (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
- Surface Ectoderm
-
Mesoderm (Gastrulation Derivatives)
- Dorsal Pancreatic Mesenchymal Cells Dorsal Pancreatic Mesenchyme
- Limb Bud Mesenchyme Cells Limb Bud
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Gut Tube (Gastrointestinal Tract)
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Ectoderm (Gastrulation Derivatives)
- Surface Ectoderm Cells Surface Ectoderm
-
Epidermis (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Pancreas (Endocrine System)
- Dorsal Pancreatic Mesenchymal Cells Dorsal Pancreatic Mesenchyme
-
Liver (Hepatobiliary System)
- Hepatic Stellate Cells Sinusoids
-
Placenta (Extraembryonic Tissues)
- Column Cytotrophoblast Cells Column Cytotrophoblast Layer
- Thymus (Hematopoietic System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for FGF10 Gene
This gene is overexpressed in Cervix - Endocervix (x5.6), Cervix - Ectocervix (x5.2), Adipose - Visceral (Omentum) (x4.8), and Breast - Mammary Tissue (x4.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF10 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGF10 Gene:
FGF10SOURCE GeneReport for Unigene cluster for FGF10 Gene:
Hs.664499Evidence on tissue expression from TISSUES for FGF10 Gene
- Lung(4.5)
- Nervous system(4.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF10 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- integumentary
- nervous
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- inner ear
- jaw
- lacrimal apparatus
- mandible
- maxilla
- middle ear
- mouth
- nose
- outer ear
- salivary gland
- skull
- tongue
- tooth
Abdomen:
- kidney
Pelvis:
- penis
- ureter
- urethra
Limb:
- arm
- digit
- finger
- foot
- forearm
- hand
- lower limb
- radius
- shin
- tibia
- toe
- ulna
- upper limb
General:
- blood
- hair
- peripheral nerve
- peripheral nervous system
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for FGF10
-
OriGene qPCR primer pairs for FGF10
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FGF10 Gene
Orthologs for FGF10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGF10 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGF10 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGF10 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FGF10 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGF10 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgf10 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgf10 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | FGF10 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgf10 34 |
|
||
| Str.15379 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | fgf10-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgf10b 34 35 |
|
||
| fgf10a 35 |
|
OneToMany | |||
| fgf10 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CS-FGF9/16/20 35 |
|
OneToMany |
- Species where no ortholog for FGF10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGF10 Gene
Paralogs for FGF10 Gene
(19) SIMAP similar genes for FGF10 Gene using alignment to 5 proteins:
Variants for FGF10 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104893885 | Pathogenic, Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730] | 44,388,366(-) | GAACT(G/T)CCCGT | upstream-variant-2KB, reference, missense | |
| rs104893886 | Pathogenic, Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730] | 44,305,155(-) | GAGGA(G/T)AGAGG | reference, missense | |
| rs104893884 | Pathogenic | 44,305,045(-) | AAACA(C/G/T)GAAGG | reference, missense, stop-gained | |
| rs104893887 | Pathogenic | 44,310,447(-) | ACAAG(A/T)AGGGG | reference, stop-gained | |
| rs104893888 | Pathogenic | 44,388,443(-) | TGGAG(A/C)AAGCT | upstream-variant-2KB, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2677507 | CNV | deletion | 23128226 |
| esv3604923 | CNV | loss | 21293372 |
| nsv4816 | CNV | deletion | 18451855 |
| nsv830277 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.43% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGF10 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF10 Gene
Disorders for FGF10 Gene
(22) MalaCards diseases for FGF10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aplasia of lacrimal and salivary glands |
|
|
| ladd syndrome |
|
|
| fgf10-related lacrimo-auriculo-dento-digital syndrome |
|
|
| clear cell acanthoma |
|
|
| apert syndrome |
|
Search FGF10 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FGF10_HUMAN- Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269 PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269 PubMed:16501574, ECO:0000269 PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for FGF10
No data available for Genatlas for FGF10 Gene
Publications for FGF10 Gene
- Structure and expression of human fibroblast growth factor-10. (PMID: 9287324) Emoto H. … Itoh N. (J. Biol. Chem. 1997) 2 3 4 22 64
- Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population. (PMID: 19727229) Wan W.D. … Lu Z.H. (Beijing Da Xue Xue Bao 2009) 3 22 46 64
- Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PMID: 18081024) Laurin N. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 22 46 64
- FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. (PMID: 17264867) Beleza-Meireles A. … NordenskjAPld A. (Eur. J. Hum. Genet. 2007) 3 22 46 64
- Mutations in different components of FGF signaling in LADD syndrome. (PMID: 16501574) Rohmann E. … Wollnik B. (Nat. Genet. 2006) 3 4 22 64
Products for FGF10 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FGF10
- EMD Millipore Purified and/or Recombinant FGF10 Protein
- Browse Kits and Assays available from EMD Millipore
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- R&D Systems Antibodies for FGF10 (FGF-10)
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- Custom Antibody ServicesOriGene Antibodies for FGF10
- Browse OriGene ELISA Kits
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- Search Origene for MassSpec and Protein Over-expression Lysates for FGF10
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGF10
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FGF10 in any vector
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- Novus Biologicals Antibodies for FGF10
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- antibodies-online Antibodies for FGF10: See all 98
- antibodies-online Kits for FGF10: See all 39
- antibodies-online Proteins for FGF10: See all 70
- Search antibodies-online for peptides
- GeneTex FGF10 antibody for FGF10
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- ViGene Biosciences adenoviral particle packaged cDNA for FGF10 gene
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- Search ViGene Biosciences for FGF10
- Santa Cruz Biotechnology (SCBT) Antibodies for FGF10
- Search Santa Cruz Biotechnology (SCBT) for FGF10 siRNA/shRNA
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- Horizon Cell Lines for FGF10
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGF10
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGF10 Gene
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