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FGF10 Gene

protein-coding   GIFtS: 68
GCID: GC05M044340

Fibroblast Growth Factor 10

  See FGF10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 101 2
Keratinocyte Growth Factor 22 3
FGF-102 3
Produced By Fibroblasts Of Urinary Bladder Lamina Propria2

External Ids:    HGNC: 36661   Entrez Gene: 22552   Ensembl: ENSG000000701937   OMIM: 6021155   UniProtKB: O155203   

Export aliases for FGF10 gene to outside databases

Previous GC identifers: GC05M044614 GC05M045481 GC05M044305 GC05M044350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF10 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for
fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that
this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and
initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound
healing. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF10 Gene:
FGF10 (fibroblast growth factor 10) is a protein-coding gene. Diseases associated with FGF10 include aplasia of lacrimal and salivary glands, and fgf10-related lacrimo-auriculo-dento-digital syndrome. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
differentiation. Required for normal branching morphogenesis. May play a role in wound healing

Gene Wiki entry for FGF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF10 gene promoter:
         c-Fos   AP-1   ATF-2   STAT3   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF10 promoter sequence
   Search Chromatin IP Primers for FGF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13-p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p13-p12

FGF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M044340:  view genomic region     (about GC identifiers)

Start:
44,303,646 bp from pter      End:
44,389,808 bp from pter
Size:
86,163 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520 (See protein sequence)
Recommended Name: Fibroblast growth factor 10 precursor  
Size: 208 amino acids; 23436 Da
Subunit: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1
1 PDB 3D structure from and Proteopedia for FGF10:
1NUN (3D)    
Secondary accessions: Q6FHT6 Q96P59

Explore the universe of human proteins at neXtProt for FGF10: NX_O15520

Explore proteomics data for FGF10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51, Asn196
  • Modification sites at PhosphoSitePlus

  • See FGF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004456.1  
    ENSEMBL proteins: 
     ENSP00000264664   ENSP00000426406  
    Reactome Protein details: O15520

    FGF10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FGF10

     
    Search eBioscience for Proteins for FGF10 

    FGF10 Antibody Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF10
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    Search eBioscience for ELISAs for FGF10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028252 FGF10

    Graphical View of Domain Structure for InterPro Entry O15520

    ProtoNet protein and cluster: O15520

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF10_HUMAN, O15520
    Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
    differentiation. Required for normal branching morphogenesis. May play a role in wound healing

         Genatlas biochemistry entry for FGF10:
    fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells
    for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in
    mesoderm

         Summary: 
    During embryonic development, FGF10 as signaling molecule is secreted from the following cells:
          selected tissues (see all 7)      
    Pancreas: Ventral Pancreatic Mesenchymal Cells (Dorsal Pancreatic Mesenchyme), Dorsal Pancreatic Mesenchymal Cells (Ventral Pancreatic Mesenchyme)
    Lung: Distal Mesodermal Progenitor Cells (Lung Mesoderm)

    It affects the following cells:
          selected tissues (see all 7)      fully expand
    Gut Tube: Pre-Pancreatic Foregut Endoderm Cells (Ventral Foregut Endoderm), Pre-Pancreatic Foregut Endoderm Cells (Prepancreatic Dorsal Foregut Endoderm)      fully expand to see all 3 cells
    Lung: Distal Lung Progenitor Cells (Lung Bud), Lung Bud Progenitor Cells (Lung Bud)      fully expand to see all 2 cells

    FGF10 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      fully expand
    Liver: Hepatic progenitor cells, Immature hepatocytes      fully expand to see all 3 cells
    Lung: Immature proximal lung cells, Early proximal lung progenitors      fully expand to see all 2 cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IDA11923311
    GO:0005111type 2 fibroblast growth factor receptor binding IPI19224135
    GO:0005515protein binding ----
    GO:0008083growth factor activity IDA11923311
    GO:0008201heparin binding IDA11923311
         
    Find genes that share ontologies with FGF10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FGF10:
     Decreased G3BP1 protein expres  Increased circadian period len 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Fgf10) (see all 23):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  mortality/aging 

    Find genes that share phenotypes with FGF10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FGF10: Fgf10tm1Ska Fgf10tm1Wss Fgf10tm1.1Sms

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF10

    miRNA
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    miRTarBase miRNAs that target FGF10:
    hsa-mir-335-5p (MIRT018544)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FGF10 (NM_004465)
    Sino Biological Human cDNA Clone for FGF10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF10_HUMAN, O15520: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    plasma membrane5
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA16597614
    GO:0005634nucleus IDA11923311
    GO:0005886plasma membrane IDA16597614
    GO:0009986cell surface NAS11923311

    Find genes that share ontologies with FGF10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF10 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR1b ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    FGFR2b ligand binding and activation0.00
    FRS2-mediated cascade0.70
    Activated point mutants of FGFR20.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with FGF10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF10 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF10
        Development FGF-family signaling

    2 BioSystems Pathways for FGF10
        Heart Development
    Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF10 (see all 13)
        Signaling by FGFR mutants
    PI3K Cascade
    Phospholipase C-mediated cascade
    FRS2-mediated cascade
    Regulation of gene expression in early pancreatic precursor cells


    Selected Kegg Pathways  (Kegg details for FGF10) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF10 (see all 6): 
              Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGF10 (O155202, 3 ENSP000002646644) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218022, 3, ENSP000004102944MINT-24798 I2D: score=4 STRING: ENSP00000410294
    POMCP011893, ENSP000002647084I2D: score=1 STRING: ENSP00000264708
    FGFBP1Q145123I2D: score=1 
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGF18ENSP000002746254STRING: ENSP00000274625
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 131):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA14975937
    GO:0001525angiogenesis IEA--
    GO:0001656metanephros development IEP18437684
    GO:0001759organ induction IEA--
    GO:0001823mesonephros development IEP18437684

    Find genes that share ontologies with FGF10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF10

    8 Novoseek inferred chemical compound relationships for FGF10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bromodeoxyuridine 44.3 6 11286634 (1), 10503993 (1), 15690149 (1), 15137055 (1) (see all 5)
    heparan sulfate 40.6 11 19755711 (2), 14707131 (1)
    dextran sulfate sodium 33.5 2 10381813 (1)
    tyrosine 26.2 6 11286634 (2), 17449030 (1), 19863897 (1), 16501574 (1)
    heparin 26.2 3 12818887 (1), 9582367 (1), 9740653 (1)
    retinoic acid 19.9 5 16622850 (1), 18977204 (1), 10862743 (1), 20301097 (1)
    vegf 8.2 8 14706196 (3), 14996996 (2), 18437684 (1), 20503389 (1)
    testosterone 0 6 18068633 (2), 15843416 (1), 10503993 (1), 15094393 (1) (see all 5)



    Find genes that share compounds with FGF10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF10 gene: 
    NM_004465.1  

    Unigene Cluster for FGF10:

    Fibroblast growth factor 10
    Hs.664499  [show with all ESTs]
    Unigene Representative Sequence: AK315314
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264664(uc003jog.1) ENST00000513107
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      QuantiFast Probe-based Assays in human, mouse, rat FGF10

    Additional mRNA sequence: 

    AB002097.1 AF411527.1 AF508782.1 AK315314.1 BC069561.1 BC105021.1 BC105023.1 BC143772.1 
    CR541665.1 CR541688.1 GQ351295.1 U67918.1 

    3 DOTS entries:

    DT.91752709  DT.120862189  DT.120862177 

    16 AceView cDNA sequences:

    BX471703 NM_004465 BC069561 AB002097 CA394078 BX280011 U67918 BX955123 
    CR541665 CR541688 BP380072 BX484361 AF411527 AF508782 AL603565 BF983177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAGAAGG
    FGF10 Expression
    About this image


    FGF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 7 entries
             Stromal Vascular Preadipocyte Progenitor Cells Vascular Adipose
             Visceral White Adipose
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Heart Tube Cells Heart Tube
             Cardiac progenitor cells (Sca1+)
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Distal Mesodermal Progenitor Cells Lung Mesoderm
             Lung Mesoderm
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Tooth
             Odontoblasts Dentin
    FGF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664499
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF10 (see all 6): 
              Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf101 , 5 fibroblast growth factor 101, 5 90.5(n)1
    90.82(a)1
      13 (67.14 cM)5
    141651  NM_008002.41  NP_032028.11 
     1186697915 
    chicken
    (Gallus gallus)
    Aves FGF101 fibroblast growth factor 10 83.58(n)
    87.32(a)
      395432  NM_204696.1  NP_990027.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia fgf10-A2 fibroblast growth factor-10 79.35(n)    AB073747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf102 fibroblast growth factor 10 77.77(n)   359830  AF544025.1 


    ENSEMBL Gene Tree for FGF10 (if available)
    TreeFam Gene Tree for FGF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF10 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
    FGF72  FGF112  FGF132  FGF222  FGF142  
    Selected SIMAP similar genes for FGF10 using alignment to 5 protein entries:     FGF10_HUMAN (see all proteins) (see all similar genes):
    KGFLP2    FGF22    KGFLP1    PRED3    FGF16    FGF7
    FGF9    FGF20    FGF12    FGF11    FGF3    FGF13
    FGF5    FGF2    FGF6    FGF14    FGF4    fgf gene

    Find genes that share paralogs with FGF10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF10 (see all 1698)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0298894
    Lacrimo-auriculo-dento-digital syndrome (LADDS)4--see VAR_0298892 I R mis40--------
    VAR_0298884
    Lacrimo-auriculo-dento-digital syndrome (LADDS)4--see VAR_0298882 C F mis40--------
    rs1048938841,2
    Cpathogenic144250110(-) AAACAC/G/TGAAGG 2 R * stg10--------
    rs1048938861,2
    Cpathogenic144250220(-) GAGGAG/TAGAGG 2 R I mis10--------
    rs1048938891,2
    Cpathogenic144255508(-) GAAGGA/GGAAAC 2 E G mis10--------
    rs1048938871,2
    Cpathogenic144255512(-) ACAAGA/TAGGGG 2 K * stg10--------
    rs1048938851,2
    Cpathogenic144333429(-) GAACTG/TCCCGT 2 C F mis10--------
    rs1048938881,2
    Cpathogenic144333506(-) TGGAGA/CAAGCT 2 R S mis10--------
    rs172346461,2
    C,F--44249683(-) GAATAC/TGAACT 1 -- ds50017Minor allele frequency- T:0.20NS NA WA CSA EA 530
    rs1915062991,2
    --44249722(+) TTCAAC/TAGATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF10 (44303646 - 44389808 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGF10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677507CNV Deletion23128226
    nsv4816CNV Loss18451855
    nsv830277CNV Gain17160897

    Human Gene Mutation Database (HGMD): FGF10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF10
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602115   
    OMIM disorders: 180920  149730  
    UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520
  • Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry
    conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which
    increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable
    expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular,
    and sublingual glands and absence of the lacrimal puncta. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia,
    a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures.
    Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and
    ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In
    addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and
    abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 6 diseases for FGF10:    
    About MalaCards
    aplasia of lacrimal and salivary glands    fgf10-related lacrimo-auriculo-dento-digital syndrome    ladd syndrome    bronchopulmonary dysplasia
    intestinal atresia    matthew-wood syndrome

    7 diseases from the University of Copenhagen DISEASES database for FGF10:
    LADD syndrome     Cleft palate     Intestinal atresia     Esophageal atresia
    Synostosis     Congenital diaphragmatic hernia     Cleft lip

    Find genes that share disorders with FGF10           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FGF10 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aplasia 60.8 13 19376597 (2), 16476029 (1), 15972105 (1), 17213838 (1) (see all 5)
    apert syndrome 60.6 2 19581825 (1), 14613973 (1)
    pfeiffer syndrome 54.8 1 14613973 (1)
    craniosynostosis 48.6 1 15282208 (1)
    hypoplasia 45.6 1 19376597 (1)
    atresia 39.3 1 15234214 (1)
    mucositis 31.9 5 11511852 (1), 15995938 (1), 15623608 (1)
    hypospadias 17.7 4 17264867 (3), 15843416 (1)
    bronchopulmonary dysplasia 16.9 5 17071719 (4)
    colitis ulcerative 11.2 1 12786629 (1)

    Genetic Association Database (GAD): FGF10
    Human Genome Epidemiology (HuGE) Navigator: FGF10 (9 documents)

    Export disorders for FGF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF10 gene, integrated from 10 sources (see all 218):
    (articles sorted by number of sources associating them with FGF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of human fibroblast growth factor-10. (PubMed id 9287324)1, 2, 3, 9 Emoto H....Itoh N. (J. Biol. Chem. 1997)
    2. Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. (PubMed id 12591959)1, 2, 9 Yeh B.K.... Mohammadi M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. (PubMed id 17264867)1, 4, 9 Beleza-Meireles A....NordenskjAPld A. (Eur. J. Hum. Genet. 2007)
    4. Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population. (PubMed id 19727229)1, 4, 9 Wan W.D....Lu Z.H. (Beijing Da Xue Xue Bao 2009)
    5. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2, 9 Beer H.-D....Werner S. (Oncogene 2005)
    6. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PubMed id 18081024)1, 4, 9 Laurin N....Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    7. Mutations in different components of FGF signaling in LADD syndrome. (PubMed id 16501574)1, 2, 9 Rohmann E.... Wollnik B. (Nat. Genet. 2006)
    8. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. (PubMed id 21743467)1, 4 Kote-Jarai Z....TybjA ( 2011)
    9. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    10. Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population. (PubMed id 20544801)1, 4 Mostowska A....Jagodzinski P.P. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2255 HGNC: 3666 AceView: FGF10 Ensembl:ENSG00000070193 euGenes: HUgn2255
    ECgene: FGF10 Kegg: 2255 H-InvDB: FGF10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF10 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF10 gene:
    Search GeneIP for patents involving FGF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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