Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FGF10 Gene

Aliases for FGF10 Gene

  • Fibroblast Growth Factor 10 2 3 5
  • Keratinocyte Growth Factor 2 3 4
  • FGF-10 3 4
  • Produced By Fibroblasts Of Urinary Bladder Lamina Propria 3

External Ids for FGF10 Gene

Previous GeneCards Identifiers for FGF10 Gene

  • GC05M044614
  • GC05M045481
  • GC05M044305
  • GC05M044350

Summaries for FGF10 Gene

Entrez Gene Summary for FGF10 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF10 Gene

FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include aplasia of lacrimal and salivary glands and ladd syndrome. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF10 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Gene Wiki entry for FGF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF10 Gene

Genomics for FGF10 Gene

Regulatory Elements for FGF10 Gene

Genomic Location for FGF10 Gene

Chromosome:
5
Start:
44,303,541 bp from pter
End:
44,389,780 bp from pter
Size:
86,240 bases
Orientation:
Minus strand

Genomic View for FGF10 Gene

Genes around FGF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF10 Gene

Proteins for FGF10 Gene

  • Protein details for FGF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15520-FGF10_HUMAN
    Recommended name:
    Fibroblast growth factor 10
    Protein Accession:
    O15520
    Secondary Accessions:
    • C7FDY0
    • Q6FHR3
    • Q6FHT6
    • Q96P59

    Protein attributes for FGF10 Gene

    Size:
    208 amino acids
    Molecular mass:
    23436 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

    Three dimensional structures from OCA and Proteopedia for FGF10 Gene

neXtProt entry for FGF10 Gene

Proteomics data for FGF10 Gene at MOPED

Post-translational modifications for FGF10 Gene

  • Glycosylation at Asn 51 and Asn 196
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF10 Gene

Domains & Families for FGF10 Gene

Graphical View of Domain Structure for InterPro Entry

O15520

UniProtKB/Swiss-Prot:

FGF10_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF10: view

No data available for Gene Families for FGF10 Gene

Function for FGF10 Gene

Molecular function for FGF10 Gene

GENATLAS Biochemistry:
fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

LifeMap Function Summary for FGF10 Gene

genes like me logo Genes that share phenotypes with FGF10: view

Human Phenotype Ontology for FGF10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF10 Gene

MGI Knock Outs for FGF10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FGF10 Gene

Localization for FGF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF10 Gene COMPARTMENTS Subcellular localization image for FGF10 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for FGF10 Gene

Pathways & Interactions for FGF10 Gene

SuperPathways for FGF10 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K events in ERBB4 signaling
4 GPCR Pathway
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with FGF10: view

SIGNOR curated interactions for FGF10 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001525 angiogenesis IEA --
GO:0001656 metanephros development IEP 18437684
genes like me logo Genes that share ontologies with FGF10: view

Drugs & Compounds for FGF10 Gene

(4) Drugs for FGF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for FGF10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF10: view

Transcripts for FGF10 Gene

mRNA/cDNA for FGF10 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF10 Gene

Fibroblast growth factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF10 Gene

No ASD Table

Relevant External Links for FGF10 Gene

GeneLoc Exon Structure for
FGF10
ECgene alternative splicing isoforms for
FGF10

Expression for FGF10 Gene

mRNA expression in normal human tissues for FGF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF10 Gene

This gene is overexpressed in Cervix - Endocervix (x5.6), Cervix - Ectocervix (x5.2), Adipose - Visceral (Omentum) (x4.8), and Breast - Mammary Tissue (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF10 Gene



SOURCE GeneReport for Unigene cluster for FGF10 Gene Hs.664499

genes like me logo Genes that share expression patterns with FGF10: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FGF10 Gene

Orthologs for FGF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF10 35
  • 93.37 (n)
  • 96.12 (a)
dog
(Canis familiaris)
Mammalia FGF10 35
  • 94.36 (n)
  • 96.62 (a)
FGF10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf10 35
  • 90.5 (n)
  • 90.82 (a)
Fgf10 16
Fgf10 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF10 35
  • 99.84 (n)
  • 100 (a)
FGF10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf10 35
  • 92.11 (n)
  • 97.1 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF10 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF10 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF10 35
  • 83.58 (n)
  • 87.32 (a)
FGF10 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf10 35
  • 76.63 (n)
  • 77.32 (a)
Str.15379 35
African clawed frog
(Xenopus laevis)
Amphibia fgf10-A 35
zebrafish
(Danio rerio)
Actinopterygii fgf10 35
fgf10b 35
  • 62.83 (n)
  • 60 (a)
fgf10a 36
  • 55 (a)
OneToMany
fgf10b 36
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 36
  • 19 (a)
OneToMany
Species with no ortholog for FGF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF10 Gene

ENSEMBL:
Gene Tree for FGF10 (if available)
TreeFam:
Gene Tree for FGF10 (if available)

Paralogs for FGF10 Gene

Paralogs for FGF10 Gene

genes like me logo Genes that share paralogs with FGF10: view

Variants for FGF10 Gene

Sequence variations from dbSNP and Humsavar for FGF10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_029888 Lacrimo-auriculo-dento-digital syndrome (LADDS)
VAR_029889 Lacrimo-auriculo-dento-digital syndrome (LADDS)
rs235164 -- 44,363,241(-) GAGCA(A/G)TTATG intron-variant
rs339498 -- 44,366,747(-) GCAAA(C/T)GCTTT intron-variant
rs339499 -- 44,366,740(+) ATTGG(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF10 Gene

Variant ID Type Subtype PubMed ID
nsv4816 CNV Loss 18451855
esv2677507 CNV Deletion 23128226
nsv830277 CNV Gain 17160897

Variation tolerance for FGF10 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF10 Gene

HapMap Linkage Disequilibrium report
FGF10
Human Gene Mutation Database (HGMD)
FGF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF10 Gene

Disorders for FGF10 Gene

MalaCards: The human disease database

(21) MalaCards diseases for FGF10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aplasia of lacrimal and salivary glands
  • absence of salivary glands
ladd syndrome
  • lacrimoauriculodentodigital syndrome
fgf10-related lacrimo-auriculo-dento-digital syndrome
apert syndrome
  • acrocephalosyndactyly
pleuropulmonary blastoma
  • pulmonary blastoma
- elite association - COSMIC cancer census association via MalaCards
Search FGF10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF10_HUMAN
  • Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269 PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269 PubMed:16501574, ECO:0000269 PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF10

Genetic Association Database (GAD)
FGF10
Human Genome Epidemiology (HuGE) Navigator
FGF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF10
genes like me logo Genes that share disorders with FGF10: view

No data available for Genatlas for FGF10 Gene

Publications for FGF10 Gene

  1. Structure and expression of human fibroblast growth factor-10. (PMID: 9287324) Emoto H. … Itoh N. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. FGF-10 and specific structural elements of dermatan sulfate size and sulfation promote maximal keratinocyte migration and cellular proliferation. (PMID: 19152659) Radek K.A. … Gallo R.L. (Wound Repair Regen 2009) 3 23
  3. Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population. (PMID: 19727229) Wan W.D. … Lu Z.H. (Beijing Da Xue Xue Bao 2009) 3 23
  4. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PMID: 18081024) Laurin N. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23
  5. Involvement of FGF and BMP family proteins and VEGF in early human kidney development. (PMID: 18437684) Carev D. … Saraga-Babic M. (Histol. Histopathol. 2008) 3 23

Products for FGF10 Gene

Sources for FGF10 Gene

Back to Top

Content