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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF10 Gene

protein-coding GIFtS: 67
GCID: GC05M044340

fibroblast growth factor 10

Explore 58 diseases affiliated with
FGF10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 10¹ ²
Keratinocyte Growth Factor 2² ³
FGF-10² ³
Produced By Fibroblasts Of Urinary Bladder Lamina Propria²

External Ids:	HGNC: 3666¹	Entrez Gene: 2255²	Ensembl: ENSG00000070193⁷	OMIM: 602115⁵	UniProtKB: O15520³

Export aliases for FGF10 gene to outside databases

Previous GC identifers: GC05M044614 GC05M045481 GC05M044305 GC05M044350

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF10:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including

embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits

mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to

the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic

epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This

gene is also implicated to be a primary factor in the process of wound healing. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell

differentiation. Required for normal branching morphogenesis. May play a role in wound healing

Gene Wiki entry for FGF10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF10 gene promoter:
c-Fos AP-1 ATF-2 STAT3 c-Jun C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF10 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13-p12 Ensembl cytogenetic band: 5p12 HGNC cytogenetic band: 5p13-p12

FGF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF10 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M044340: view genomic region (about GC identifiers)

Start:	44,303,646 bp from pter	End:	44,389,808 bp from pter
Size:	86,163 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520 (See protein sequence)

Recommended Name: Fibroblast growth factor 10 precursor

Size: 208 amino acids; 23436 Da

Subunit: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1

Subcellular location: Secreted (Potential)

1 PDB 3D structure from and Proteopedia for FGF10:

1NUN (3D)

Secondary accessions: Q6FHT6 Q96P59

Explore the universe of human proteins at neXtProt for FGF10: NX_O15520

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15520

FGF10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004456.1

ENSEMBL proteins:

ENSP00000264664 ENSP00000426406

Reactome Protein details: O15520
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant FGF10 Protein
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	Novus Biologicals FGF10 Proteins Novus Biologicals FGF10 Lysate
	Sino Biological Recombinant Protein for FGF10
	ProSpec Recombinant Protein for FGF10
	Uscn Proteins for FGF10

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	16597614
GO:0005634	nucleus	IDA	16597614
GO:0005886	plasma membrane	IDA	16597614
GO:0009986	cell surface	NAS	11923311

FGF10 for ontologies About GeneDecksing

FGF10 Antibody Products:

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Assay Products for FGF10:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FGF10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FGF10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF10 for domains About GeneDecksing

3 InterPro domains/families:

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR002209 GF_heparin-bd

Graphical View of Domain Structure for InterPro Entry O15520

ProtoNet protein and cluster: O15520

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell

differentiation. Required for normal branching morphogenesis. May play a role in wound healing

Genatlas biochemistry entry for FGF10:

fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for

the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm

Summary:

During embryonic development, FGF10 as signaling molecule is secreted from the following cells: Distal Mesodermal Progenitor Cells in Lung Mesoderm, Dorsal Pancreatic Mesenchymal Cells in Dorsal Pancreatic Mesenchyme (see all 7).

It affects the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Definitive Endoderm Cells in Definitive Endoderm (see all 10).

FGF10 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Nkx2-1 induced endoderm, Posterior foregut endoderm-like cells (see all 10).

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF10
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FGF10

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGF10
		Search LifeMap BioReagents cell lines for FGF10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF10

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005104	fibroblast growth factor receptor binding	IDA	11923311
GO:0005111	type 2 fibroblast growth factor receptor binding	IPI	19224135
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IDA	15690149
GO:0008201	heparin binding	IDA	11923311

FGF10 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FGF10:

Decreased G3BP1 protein expres

Increased circadian period len

Animal Models:
Mouse knock-outs for FGF10: Fgf10^tm1Ska Fgf10^tm1Wss Fgf10^tm1.1Sms
15/23 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Fgf10) (see all 23):

adipose tissue	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	integument	limbs/digits/tail	mortality/aging

FGF10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FGF10

Development FGF-family signaling

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF10 (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for FGF10

Development FGF-family signaling

2 BioSystems Pathways for FGF10

	Heart Development
	Regulation of Actin Cytoskeleton

5/50 Reactome Pathways for FGF10 (see all 50)

	FGFR2 ligand binding and activation
	FGFR ligand binding and activation
	Signaling by EGFR in Cancer
	Signaling by FGFR2 mutants
	Downstream signal transduction

4 Kegg Pathways (Kegg details for FGF10):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FGF10

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/25 Interacting proteins for FGF10 (O15520^{2, 3} ENSP00000264664⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR2	P21802²^,³, ENSP00000410294⁴	MINT-24798 I2D: score=4 STRING: ENSP00000410294
POMC	P01189³, ENSP00000264708⁴	I2D: score=1 STRING: ENSP00000264708
FGFBP1	Q14512³	I2D: score=1
FGF1	ENSP00000338548⁴	STRING: ENSP00000338548
FGF18	ENSP00000274625⁴	STRING: ENSP00000274625

About this table

Gene Ontology (GO): 5/125 biological process terms (GO ID links to tree view) (see all 125): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	14975937
GO:0001525	angiogenesis	IEA	--
GO:0001656	metanephros development	IEP	18437684
GO:0001759	organ induction	IEA	--
GO:0001823	mesonephros development	IEP	18437684

FGF10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FGF10 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF10
8 Novoseek chemical compound relationships for FGF10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bromodeoxyuridine	44.3	6	11286634 (1), 10503993 (1), 15690149 (1), 15137055 (1) (see all 5)
heparan sulfate	40.6	11	19755711 (2), 14707131 (1)
dextran sulfate sodium	33.5	2	10381813 (1)
tyrosine	26.2	6	11286634 (2), 17449030 (1), 19863897 (1), 16501574 (1)
heparin	26.2	3	12818887 (1), 9582367 (1), 9740653 (1)
retinoic acid	19.9	5	16622850 (1), 18977204 (1), 10862743 (1), 20301097 (1)
vegf	8.2	8	14706196 (3), 14996996 (2), 18437684 (1), 20503389 (1)
testosterone	0	6	18068633 (2), 15843416 (1), 10503993 (1), 15094393 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about FGF10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF10 gene:

NM_004465.1

Unigene Cluster for FGF10:

Fibroblast growth factor 10

Hs.664499 [show with all ESTs]

Unigene Representative Sequence: AK315314

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264664(uc003jog.1) ENST00000513107

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF10
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF10

Additional cDNA sequence:

AB002097.1 AF411527.1 AF508782.1 AK315314.1 BC069561.1 BC105021.1 BC105023.1 BC143772.1

CR541665.1 CR541688.1 GQ351295.1 U67918.1

3 DOTS entries:

DT.91752709 DT.120862189 DT.120862177

16 AceView cDNA sequences:

AB002097 NM_004465 BX471703 BX280011 U67918 CA394078 BC069561 BX955123

AL603565 AF411527 CR541688 BX484361 CR541665 AF508782 BP380072 BF983177

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAAGAAGG

About this image

FGF10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/27 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 27)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Vascular Adipose

Stromal Vascular Preadipocyte Progenitor Cells

Selective marker (cell-identifying gene)

Adipose

Myocardium

Distal Mesodermal Progenitor Cells

Lung

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Heart

Primitive Heart Tube

Primitive Heart Tube Cells

Myocardium

Lung

Trachea

Airway Smooth Muscle Cells

Lung, Smooth Muscle

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FGF10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF10

SOURCE GeneReport for Unigene cluster: Hs.664499

SABiosciences Expression via Pathway-Focused PCR Arrays including FGF10 (see all 6):

Growth Factors in human mouse rat

Wound Healing in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Common Cytokines in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FGF10 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGF10¹	fibroblast growth factor 10	84.39(n) 88.29(a)		395432 NM_204696.1 NP_990027.1
lizard (Anolis carolinensis)	Reptilia	--	--	68(a)	1 ↔ 1	2(5625236-5711595)
African clawed frog (Xenopus laevis)	Amphibia	fgf10-A²	fibroblast growth factor-10	79.35(n)		AB073747.1
zebrafish (Danio rerio)	Actinopterygii	fgf10²	fibroblast growth factor 10	77.77(n)		359830 AF544025.1
worm (Caenorhabditis elegans)	Secernentea	let-756⁶	Protein let-756	10(a)	1 → many	III(6407076-6409965)

ENSEMBL Gene Tree for FGF10 (if available)
TreeFam Gene Tree for FGF10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF10 gene

FGF12² FGF5² FGF20² FGF16² FGF4² FGF9² FGF6² FGF3²

FGF7² FGF11² FGF13² FGF22² FGF14²

18/19 SIMAP similar genes for FGF10 using alignment to 5 protein entries: FGF10_HUMAN (see all proteins) (see all similar genes):

KGFLP2 FGF22 KGFLP1 PRED3 FGF16 FGF7

FGF9 FGF20 FGF12 FGF11 FGF3 FGF13

FGF5 FGF2 FGF6 FGF14 FGF4 fgf gene

FGF10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104893884^1,2	C,	pathogenic	44258105(-)	`AAACAC/G/TGAAGG`	3	R G *	mis¹ stg¹		0	--	--	--	--
rs104893886^1,2	C	pathogenic	44258215(-)	`GAGGAG/TAGAGG`	2	R I	mis¹		0	--	--	--	--
rs104893889^1,2	C	pathogenic	44263503(-)	`GAAGGA/GGAAAC`	2	E G	mis¹		0	--	--	--	--
rs104893887^1,2	C	pathogenic	44263507(-)	`ACAAGA/TAGGGG`	2	K *	stg¹		0	--	--	--	--
rs104893885^1,2	C	pathogenic	44341387(-)	`GAACTG/TCCCGT`	2	C F	mis¹		0	--	--	--	--
rs104893888^1,2	C	pathogenic	44341464(-)	`TGGAGA/CAAGCT`	2	R S	mis¹		0	--	--	--	--
rs111763965^1,2	C,F,	--	44258050(+)	`TTGCCT/ATCCTC`	1	--	ds500¹		3		CSA EU	1328
rs147715509^1,2	C,F,	--	44258062(+)	`ATGAGC/G/TGTACC`	3	H P R	mis¹		2		NA EU	5873
rs17234639^1,2	C,F,H,	--	44258091(-)	`AACACC/TTCTGC`	2	T	syn¹ ese³		8		NS NA WA	5628
rs17228255^1,2	C,F,	--	44258332(-)	`GGACTG/AGAGTT`	1	--	int¹		2		NS NA	286

HapMap Linkage Disequilibrium report for FGF10 (44303646 - 44389808 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FGF10
4 Indels: 93012 93010 80895 93011
Human Gene Mutation Database (HGMD): FGF10

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF10

DNA2.0 Custom Variant and Variant Library Synthesis for FGF10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGF10 for disorders           About GeneDecksing

OMIM gene information: 602115
OMIM disorders: 180920  149730
UniProtKB/Swiss-Prot: FGF10_HUMAN, O15520

Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG)

[MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal,

parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by

irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which

increases the risk of dental erosion, dental caries, periodontal disease and oral infections

Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as

Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal

development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by

aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel

hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism,

malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and

severe syndactyly are not observed

20/58 diseases for FGF10 (see all 58): About MalaCards

gilles de la tourette syndrome aplasia of lacrimal and salivary glands mesenteric vascular occlusion attention deficit hyperactivity disorder

cleft lip/palate cleft lip graft versus host disease clear cell acanthoma

congenital diaphragmatic hernia pfeiffer syndrome bronchopulmonary dysplasia dental caries

craniosynostosis intestinal atresia tourette syndrome ladd syndrome

ectodermal dysplasia acrocephalosyndactylia muscle hypertrophy acanthoma

7 diseases from the University of Copenhagen DISEASES database for FGF10:

LADD syndrome Intestinal atresia Cleft palate Esophageal atresia

Synostosis Congenital diaphragmatic hernia Mesenteric vascular occlusion

10/22 Novoseek disease relationships for FGF10 gene (see all 22) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aplasia	60.8	13	19376597 (2), 16476029 (1), 15972105 (1), 17213838 (1) (see all 5)
apert syndrome	60.6	2	19581825 (1), 14613973 (1)
pfeiffer syndrome	54.8	1	14613973 (1)
craniosynostosis	48.6	1	15282208 (1)
hypoplasia	45.6	1	19376597 (1)
atresia	39.3	1	15234214 (1)
mucositis	31.9	5	11511852 (1), 15995938 (1), 15623608 (1)
hypospadias	17.7	4	17264867 (3), 15843416 (1)
bronchopulmonary dysplasia	16.9	5	17071719 (4)
colitis ulcerative	11.2	1	12786629 (1)

Human Genome Epidemiology (HuGE) Navigator: FGF10 (9 documents)

Export disorders for FGF10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FGF10 gene, integrated from 9 sources (see all 211):
(articles sorted by number of sources associating them with FGF10)

Utopia: connect your pdf to the dynamic
world of online information

Structure and expression of human fibroblast growth factor-10. (PubMed id 9287324)^{1, 2, 3, 9} Emoto H....Itoh N. (1997)
Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. (PubMed id 12591959)^{1, 2, 9} Yeh B.K.... Mohammadi M. (2003)
The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)^{1, 2, 9} Beer H.-D....Werner S. (2005)
Mutations in different components of FGF signaling in LADD syndrome. (PubMed id 16501574)^{1, 2, 9} Rohmann E.... Wollnik B. (2006)
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)^{1, 2} Zhang X....Ornitz D.M. (2006)
LADD syndrome is caused by FGF10 mutations. (PubMed id 16630169)^{1, 2} Milunsky J.M.... Everman D.B. (2006)
Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. (PubMed id 15654336)^{1, 2} Entesarian M.... Dahl N. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
FGF-10 is a chemotactic factor for distal epithelial buds during lung development. (PubMed id 9740653)^{1, 9} Park W.Y....Cardoso W.V. (1998)
FGF-10 and specific structural elements of dermatan sulfate size and sulfation promote maximal keratinocyte migration and cellular proliferation. (PubMed id 19152659)^{1, 9} Radek K.A....Gallo R.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2255	HGNC: 3666	AceView: FGF10	Ensembl:ENSG00000070193	euGenes: HUgn2255
ECgene: FGF10	Kegg: 2255	H-InvDB: FGF10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FGF10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF10	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf10/

Intellectual Property for FGF10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FGF10 gene:
Search GeneIP for patents involving FGF10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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FGF10 Gene

fibroblast growth factor 10

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