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Aliases for FGF10 Gene

Aliases for FGF10 Gene

  • Fibroblast Growth Factor 10 2 3
  • Keratinocyte Growth Factor 2 3 4
  • FGF-10 3 4
  • Produced By Fibroblasts Of Urinary Bladder Lamina Propria 3

External Ids for FGF10 Gene

Summaries for FGF10 Gene

Entrez Gene Summary for FGF10 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF10 Gene

FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include aplasia of lacrimal and salivary glands and ladd syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF10 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Gene Wiki entry for FGF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF10 Gene

Genomics for FGF10 Gene

Genomic Location for FGF10 Gene

Start:
44,303,544 bp from pter
End:
44,389,706 bp from pter
Size:
86,163 bases
Orientation:
Minus strand

Genomic View for FGF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF10 Gene

Regulatory Elements for FGF10 Gene

Proteins for FGF10 Gene

  • Protein details for FGF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15520-FGF10_HUMAN
    Recommended name:
    Fibroblast growth factor 10
    Protein Accession:
    O15520
    Secondary Accessions:
    • C7FDY0
    • Q6FHR3
    • Q6FHT6
    • Q96P59

    Protein attributes for FGF10 Gene

    Size:
    208 amino acids
    Molecular mass:
    23436 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

    Three dimensional structures from OCA and Proteopedia for FGF10 Gene

neXtProt entry for FGF10 Gene

Proteomics data for FGF10 Gene at MOPED

Post-translational modifications for FGF10 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn51 and Asn196

Other Protein References for FGF10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF10 Gene

Domains for FGF10 Gene

UniProtKB/Swiss-Prot:

FGF10_HUMAN
Family:
  • Belongs to the heparin-binding growth factors family.:
    • O15520
genes like me logo Genes that share domains with FGF10: view

No data available for Gene Families for FGF10 Gene

Function for FGF10 Gene

Molecular function for FGF10 Gene

GENATLAS Biochemistry: fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

LifeMap Function Summary for FGF10 Gene

FGF10 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IDA 11923311
GO:0005111 type 2 fibroblast growth factor receptor binding IPI 19224135
GO:0005515 protein binding IPI 12591959
GO:0008083 growth factor activity IDA 11923311
GO:0008201 heparin binding IDA 11923311
genes like me logo Genes that share ontologies with FGF10: view
genes like me logo Genes that share phenotypes with FGF10: view

Animal Models for FGF10 Gene

MGI Knock Outs for FGF10:

miRNA for FGF10 Gene

miRTarBase miRNAs that target FGF10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF10 Gene

Localization for FGF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF10 Gene COMPARTMENTS Subcellular localization image for FGF10 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16597614
GO:0005634 nucleus IDA 11923311
GO:0005886 plasma membrane IDA 16597614
GO:0009986 cell surface NAS 11923311
genes like me logo Genes that share ontologies with FGF10: view

Pathways for FGF10 Gene

SuperPathways for FGF10 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF10: view

Gene Ontology (GO) - Biological Process for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000187 activation of MAPK activity IDA 14975937
GO:0001525 angiogenesis IEA --
GO:0001656 metanephros development IEP 18437684
GO:0001759 organ induction IEA --
genes like me logo Genes that share ontologies with FGF10: view

Compounds for FGF10 Gene

(8) Novoseek inferred chemical compound relationships for FGF10 Gene

Compound -log(P) Hits PubMed IDs
bromodeoxyuridine 44.3 5
heparan sulfate 40.6 3
dextran sulfate sodium 33.5 1
tyrosine 26.2 5
heparin 26.2 3
genes like me logo Genes that share compounds with FGF10: view

Transcripts for FGF10 Gene

mRNA/cDNA for FGF10 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF10 Gene

Fibroblast growth factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF10 Gene

No ASD Table

Relevant External Links for FGF10 Gene

GeneLoc Exon Structure for
FGF10
ECgene alternative splicing isoforms for
FGF10

Expression for FGF10 Gene

mRNA expression in normal human tissues for FGF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF10 Gene

This gene is overexpressed in Cervix - Endocervix (5.6), Cervix - Ectocervix (5.2), Adipose - Visceral (Omentum) (4.8), and Breast - Mammary Tissue (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGF10 Gene

SOURCE GeneReport for Unigene cluster for FGF10 Gene Hs.664499

genes like me logo Genes that share expressions with FGF10: view

Orthologs for FGF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF10 36
  • 99.84 (n)
  • 100 (a)
FGF10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF10 36
  • 93.37 (n)
  • 96.12 (a)
dog
(Canis familiaris)
Mammalia FGF10 36
  • 94.36 (n)
  • 96.62 (a)
FGF10 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf10 36
  • 90.5 (n)
  • 90.82 (a)
Fgf10 16
Fgf10 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF10 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF10 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf10 36
  • 92.11 (n)
  • 97.1 (a)
chicken
(Gallus gallus)
Aves FGF10 36
  • 83.58 (n)
  • 87.32 (a)
FGF10 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fgf10-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf10 36
  • 76.63 (n)
  • 77.32 (a)
Str.15379 36
zebrafish
(Danio rerio)
Actinopterygii fgf10 36
fgf10a 37
  • 55 (a)
OneToMany
fgf10b 36
  • 62.83 (n)
  • 60 (a)
fgf10b 37
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 37
  • 19 (a)
OneToMany
Species with no ortholog for FGF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF10 Gene

ENSEMBL:
Gene Tree for FGF10 (if available)
TreeFam:
Gene Tree for FGF10 (if available)

Paralogs for FGF10 Gene

Paralogs for FGF10 Gene

genes like me logo Genes that share paralogs with FGF10: view

Variants for FGF10 Gene

Sequence variations from dbSNP and Humsavar for FGF10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs235164 -- 44,363,241(-) GAGCA(A/G)TTATG intron-variant
rs339498 -- 44,366,747(-) GCAAA(C/T)GCTTT intron-variant
rs339499 -- 44,366,740(+) ATTGG(A/G)AAAAG intron-variant
rs339500 -- 44,365,946(-) ATTTT(C/T)CAACT intron-variant
rs339501 -- 44,365,531(+) TAACA(C/T)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF10 Gene

Variant ID Type Subtype PubMed ID
nsv4816 CNV Loss 18451855
esv2677507 CNV Deletion 23128226
nsv830277 CNV Gain 17160897

Relevant External Links for FGF10 Gene

HapMap Linkage Disequilibrium report
FGF10
Human Gene Mutation Database (HGMD)
FGF10

Disorders for FGF10 Gene

(2) OMIM Diseases for FGF10 Gene (602115)

UniProtKB/Swiss-Prot

FGF10_HUMAN
  • Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269 PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269 PubMed:16501574, ECO:0000269 PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(22) Novoseek inferred disease relationships for FGF10 Gene

Disease -log(P) Hits PubMed IDs
aplasia 60.8 6
apert syndrome 60.6 2
pfeiffer syndrome 54.8 1
craniosynostosis 48.6 1
hypoplasia 45.6 1

Relevant External Links for FGF10

Genetic Association Database (GAD)
FGF10
Human Genome Epidemiology (HuGE) Navigator
FGF10
genes like me logo Genes that share disorders with FGF10: view

Publications for FGF10 Gene

  1. Structure and expression of human fibroblast growth factor-10. (PMID: 9287324) Emoto H. … Itoh N. (J. Biol. Chem. 1997) 2 3 4 23
  2. Mutations in different components of FGF signaling in LADD syndrome. (PMID: 16501574) Rohmann E. … Wollnik B. (Nat. Genet. 2006) 3 4 23
  3. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer H.-D. … Werner S. (Oncogene 2005) 3 4 23
  4. Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. (PMID: 12591959) Yeh B.K. … Mohammadi M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  5. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. (PMID: 17264867) Beleza-Meireles A. … NordenskjAPld A. (Eur. J. Hum. Genet. 2007) 3 23 49

Products for FGF10 Gene

Sources for FGF10 Gene

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