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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF1 Gene

protein-coding GIFtS: 73
GCID: GC05M141953

fibroblast growth factor 1 (acidic)

(Previous symbol: FGFA)

Explore 98 diseases affiliated with
FGF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fibroblast Growth Factor 1 (Acidic)¹ ²		Heparin-Binding Growth Factor 1² ³
FGFA¹ ² ³ ⁵		FGF-1² ³
ECGF¹ ² ³		HBGF-1² ³
AFGF¹ ²		Beta-Endothelial Cell Growth Factor²
ECGF-Beta¹		Endothelial Cell Growth Factor, Alpha²
ECGFA¹ ²		Endothelial Cell Growth Factor, Beta²
ECGFB¹ ²		Fibroblast Growth Factor 1²
FGF-Alpha¹		AFGF¹ ²
GLIO703¹ ²		Acidic Fibroblast Growth Factor³
HBGF1¹ ²		Endothelial Cell Growth Factor³

External Ids:	HGNC: 3665¹	Entrez Gene: 2246²	Ensembl: ENSG00000113578⁷	OMIM: 131220⁵	UniProtKB: P05230³

ORGUL members:
	NONCODE:n334117 n333721 n340669 n407227

Export aliases for FGF1 gene to outside databases

Previous GC identifers: GC05M141873 GC05M142555 GC05M142001 GC05M137120

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF1:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including

embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as

a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for

a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.

Multiple alternatively spliced variants encoding different isoforms have been described. (provided by RefSeq, Jan

2009)

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation

and cell migration. Functions as potent mitogen in vitro

Gene Wiki entry for FGF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF1 gene promoter:
PPAR-gamma1 AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FGF1 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3-q33.2

FGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M141953: view genomic region (about GC identifiers)

Start:	141,971,743 bp from pter	End:	142,077,635 bp from pter
Size:	105,893 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

n407227
n333721
n340669
n334117

lncRNA
Full Legend

141971742 142024689 142077635 chr5

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230 (See protein sequence)

Recommended Name: Fibroblast growth factor 1 precursor

Size: 155 amino acids; 17460 Da

Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors

(FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a

complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate

containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with S100A13. Interacts with LRRC59.

Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and

FIBP may cooperatively interact with FGF1

Subcellular location: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable

signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical

pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous

FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol.

Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1,

as well as LRRC59

6/87 PDB 3D structures from and Proteopedia for FGF1 (see all 87):

1AXM (3D)

1DJS (3D)

1DZC (3D)

1DZD (3D)

1E0O (3D)

1EVT (3D)

Secondary accessions: B2R5T0 D3DQF2 P07502 Q16588

Alternative splicing: 2 isoforms: P05230-1 P05230-2

Explore the universe of human proteins at neXtProt for FGF1: NX_P05230

Post-translational modifications:

In the nucleus, phosphorylated by PKC/PRKCD¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05230

FGF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (14 alternative transcripts):

NP_000791.1 NP_001138364.1 NP_001138406.1 NP_001138407.1 NP_001244134.1 NP_001244135.1 NP_001244136.1 NP_001244137.1

NP_001244138.1 NP_001244139.1 NP_001244140.1 NP_001244141.1 NP_149127.1 NP_149128.1

ENSEMBL proteins:

ENSP00000352329 ENSP00000367285 ENSP00000338548 ENSP00000354231 ENSP00000383969

ENSP00000404742 ENSP00000396195 ENSP00000378005 ENSP00000399458

Reactome Protein details: P05230
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant FGF1 Protein
	R&D Systems Recombinant & Natural Proteins for FGF1 (FGF acidic)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): FGF1 OriGene Protein Over-expression Lysate (see all 4): FGF1 OriGene Custom Protein Services for FGF1
	GenScript Purified and Recombinant Proteins for FGF1
	Novus Biologicals FGF1 Proteins Novus Biologicals FGF1 Lysates
	Sino Biological Recombinant Protein for FGF1
	ProSpec Recombinant Protein for FGF1
	Uscn Proteins for FGF1

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	18400376
GO:0005634	nucleus	--	--
GO:0005730	nucleolus	IEA	--

FGF1 for ontologies About GeneDecksing

FGF1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FGF1 (FGF acidic)
	Cell Signaling Technology (CST) Antibodies for FGF1
	OriGene Antibodies (see all 3): FGF1 OriGene Custom Antibody Services for FGF1
	GenScript Superior Antibodies for FGF1
	Novus Biologicals FGF1 Antibodies
	Search for Antibodies for FGF1 at Abcam
	Uscn Antibodies for FGF1
	ThermoFisher Antibodies for FGF1

Assay Products for FGF1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FGF1 (FGF acidic) (see first)
	R&D Systems Multiplex/Array Assay Kits & Reagents for FGF1 (FGF acidic)
	See all other biochemical assays at R&D Systems
	GenScript Custom Assay Services for FGF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FGF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF1 for domains About GeneDecksing

3 InterPro domains/families:

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR002209 GF_heparin-bd

Graphical View of Domain Structure for InterPro Entry P05230

ProtoNet protein and cluster: P05230

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation

and cell migration. Functions as potent mitogen in vitro

Genatlas biochemistry entry for FGF1:

fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of

synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly

expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar

cortex,also expressed in the retina (accessible to pharmacologic regulation)

miRNA Products:		OriGene 3'-UTR Clone (see all 6): FGF1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF1
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF1 (see all 54):
		hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: FGF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF1 (see all 7) OriGene shRNA RFP: FGF1 OriGene siRNA: FGF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FGF1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF1 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF1 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): FGF1 (NM_001144934)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGF1
		Search LifeMap BioReagents cell lines for FGF1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005104	fibroblast growth factor receptor binding	IPI	12815063
GO:0005515	protein binding	IPI	14732692
GO:0008083	growth factor activity	IDA	--
GO:0008201	heparin binding	IDA	--
GO:0030544	Hsp70 protein binding	IEA	--

FGF1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FGF1:

Increased G1 DNA content

Increased number of mitotic ce

Animal Models:
Mouse knock-out Fgf1^tm1Bas for FGF1
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fgf1):

hematopoietic system

homeostasis/metabolism

nervous system

normal

FGF1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/33 super-pathways (see all 33) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

FGFR2c binds to FGF

8/18 pathways (see all 18)
FGFR2c binds to FGF	1.00	FGFR4 ligand binding and activation	0.73
FGFR2c ligand binding and activation	1.00	FGFR1c ligand binding and activation	0.71
FGFR3c ligand binding and activation	0.79	Signaling by activated point mutants of FGFR1	0.71
FGFR3 ligand binding and activation	0.79	FGFR1 ligand binding and activation	0.59

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FGF1

Development FGF-family signaling

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF1 (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for FGF1

	Angiogenesis
	Tyrosine Kinases / Adaptors

1 GeneGo (Thomson Reuters) Pathway for FGF1

Development FGF-family signaling

4 BioSystems Pathways for FGF1

	Regulation of Actin Cytoskeleton
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	FGF signaling pathway

5/61 Reactome Pathways for FGF1 (see all 61)

	FGFR2 ligand binding and activation
	FGFR ligand binding and activation
	Signaling by EGFR in Cancer
	Signaling by FGFR2 mutants
	Downstream signal transduction

4 Kegg Pathways (Kegg details for FGF1):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FGF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for FGF1 (P05230^{1, 2, 3} ENSP00000338548⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR2	P21802¹^,²^,³, ENSP00000410294⁴	EBI-698068,EBI-1028658 MINT-25002 I2D: score=4 STRING: ENSP00000410294
FGFR3	P22607¹^,³, ENSP00000260795⁴	EBI-698068,EBI-348399 I2D: score=4 STRING: ENSP00000260795
CSNK2A2	P19784³, ENSP00000262506⁴	I2D: score=2 STRING: ENSP00000262506
CSNK2B	P67870³, ENSP00000365025⁴	I2D: score=2 STRING: ENSP00000365025
FGFBP1	Q14512³, ENSP00000259988⁴	I2D: score=2 STRING: ENSP00000259988

About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001759	organ induction	IEA	--
GO:0001934	positive regulation of protein phosphorylation	IEA	--
GO:0007165	signal transduction	NAS	3778488
GO:0007243	intracellular protein kinase cascade	--	--

FGF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FGF1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF1

1 HMDB Compound for FGF1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heparin	Arteven (see all 17)	9005-49-6	--

8 DrugBank Compounds for FGF1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Naphthalene Trisulfonate	--	--	target	--	17139284 17016423 10592235
Pentosan Polysulfate	--	37300-21-3	target	antagonist	8867461 17071728 8946244
Sucrose Octasulfate	--	57680-56-5	target	--	17139284 17016423 10592235
Formic Acid	Aminic acid (see all 5)	64-18-6	target	--	17139284 17016423
N,O6-Disulfo-Glucosamine	--	--	target	--	17139284 17016423
O2-Sulfo-Glucuronic Acid	--	--	target	--	17139284 17016423
5-AMINO-NAPHTALENE-2-MONOSULFONATE	--	--	target	--	10592235
Amlexanox	Amlexanox [USAN:INN:JAN] (see all 3)	68302-57-8	target	inhibitor	16300395

10/92 Novoseek chemical compound relationships for FGF1 gene (see all 92) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparin	78.8	489	10413500 (10), 7638745 (8), 10664506 (8), 10226073 (8) (see all 99)
amlexanox	75.2	25	20178375 (4), 18164517 (2), 16300395 (2), 9712836 (2) (see all 6)
inositol hexasulfate	73.2	9	7521397 (3), 8950275 (2), 1721051 (1), 10848963 (1)
sucrose octasulfate	73	23	7692970 (7), 7520817 (3), 8565003 (2), 19034645 (1) (see all 5)
safrole oxide	72.8	3	15763947 (1), 11931706 (1), 13678651 (1)
heparan sulfate	70.1	64	10362842 (5), 10673367 (5), 9516424 (4), 7537691 (3) (see all 24)
tyrosine	59	81	11162655 (4), 7693700 (3), 9647656 (3), 10413500 (3) (see all 54)
su5402	57.5	1	11146443 (1)
amanitin	51.6	2	9003041 (1), 9406911 (1)
vegf	51.2	85	9704334 (7), 14764221 (4), 10451491 (4), 11352499 (3) (see all 37)

Search CenterWatch for drugs/clinical trials and news about FGF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF1 gene (14 alternative transcripts):

NM_000800.4 NM_001144892.2 NM_001144934.1 NM_001144935.1 NM_001257205.1 NM_001257206.1 NM_001257207.1 NM_001257208.1

NM_001257209.1 NM_001257210.1 NM_001257211.1 NM_001257212.1 NM_033136.3 NM_033137.2

Unigene Cluster for FGF1:

Fibroblast growth factor 1 (acidic)

Hs.483635 [show with all ESTs]

Unigene Representative Sequence: NM_000800

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359370(uc011dbi.2 uc003lmm.3 uc003lmn.4 uc003lmp.4 uc003lmq.3 uc010jgj.3 uc003lmr.3 uc003lms.4 uc021yew.1)

ENST00000378046 ENST00000337706 ENST00000360966 ENST00000489937 ENST00000407758

ENST00000494344 ENST00000441680 ENST00000419524 ENST00000494579 ENST00000394496

ENST00000411960

miRNA Products:		OriGene 3'-UTR Clone (see all 6): FGF1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF1
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF1 (see all 54):
		hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: FGF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF1 (see all 7) OriGene shRNA RFP: FGF1 OriGene siRNA: FGF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF1 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF1 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): FGF1 (NM_001144934)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FGF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF1

Additional cDNA sequence:

AK289762.1 AK312301.1 BC032697.1 DQ655917.2 L01485.1 L01487.1 M13361.1 M60515.1

M60516.1 M74028.1 S67291.1 S67292.1 S67294.1 X51943.1 X65778.1 X65779.1

14 DOTS entries:

DT.75172191 DT.316852 DT.120822824 DT.100755318 DT.120822956 DT.316853 DT.99999797 DT.120822822

DT.95174755 DT.100649059 DT.120822823 DT.120822839 DT.120822945 DT.120822952

24/130 AceView cDNA sequences (see all 130):

BX119756 M60515 AI082417 BQ006675 S67292 NM_000800 AA918107 BE464377

S67294 AA348518 M74028 CF127400 F06068 S67291 AI359575 L01487

AI245781 NM_033137 BX444567 BQ876462 N47796 CD634782 AA877217 AA348519

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 (see all 16) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f	·	10g	·
SP1:			-		-		-						-		-		-		-		-		-		-		-		-
SP2:													-		-		-		-		-		-		-		-		-
SP3:													-		-		-		-		-				-		-		-
SP4:													-		-		-		-		-		-		-		-		-
SP5:													-		-		-		-		-		-		-		-		-

ExUns:	10h	·	10i	·	10j
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for FGF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGAAGGGG

About this image

FGF1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Endothelium

Microvessels

Pericytes

Pericytes

Gut Tube

Ventral Foregut Endoderm

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Nkx2-1 GFP+ cells (Efficient derivation...)

Cardiomyocyte-like cells (Spontaneous differen...)

See FGF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF1

SOURCE GeneReport for Unigene cluster: Hs.483635

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal

muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including FGF1 (see all 8):

Osteogenesis in human mouse rat

Growth Factors in human mouse rat

Angiogenic Growth Factors in human mouse rat

Angiogenesis in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FGF1
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FGF1 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fgf1^{1 , 5}	fibroblast growth factor 1^{1, 5}	90.54(n)¹ 95.48(a)¹		18 (20.74 cM)⁵ 14164¹ NM_010197.3¹ NP_034327.1¹ 38838673⁵
chicken (Gallus gallus)	Aves	FGF1¹	fibroblast growth factor 1 (acidic)	79.78(n) 90.32(a)		396094 NM_205180.1 NP_990511.1
lizard (Anolis carolinensis)	Reptilia	FGF1⁶	--	79(a)	1 ↔ 1	2(126772826-126790601)
zebrafish (Danio rerio)	Actinopterygii	fgf1a¹	fibroblast growth factor 1a	57.21(n) 55.97(a)		393733 NM_200760.1 NP_957054.1
honey bee (Apis mellifera)	Insecta	--	--	21(a)	1 → many	Group1.40(5135-9659)

ENSEMBL Gene Tree for FGF1 (if available)
TreeFam Gene Tree for FGF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF1 gene

FGF17² FGF8² FGF18² FGF2²

18/19 SIMAP similar genes for FGF1 using alignment to 6 protein entries: FGF1_HUMAN (see all proteins) (see all similar genes):

FGFA fgf gene FGF2 FGF16 FGF9 FGF20

FGF12 FGF18 FGF13 KGFLP1 FGF11 FGF14

FGF6 FGF7 FGF10 FGF5 FGF22 FGF3

FGF1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75378760^1,2	C,F,	--	141971249(+)	`TTAAAA/CTGATA`	14	--	ds500¹		1		WA	118
rs13179022^1,2	C,F,H,	--	141971281(+)	`AATCTA/GTAGCT`	14	--	ds500¹		32		EA NS NA WA CSA	3090
rs10569956^1,2	C	--	141971362(+)	`AAATG-/TTTTTTT`	14	--	ds500¹		1		CSA	2
rs142483782^1,2	C	--	141971362(+)	`AAATG-/TTTTTTT`	14	--	ds500¹		0	--	--	--	--
rs17217667^1,2	C,F,	--	141971403(-)	`GCTCGT/AGCTTA`	14	--	ds500¹		2		NS NA	106
rs186336716^1,2		--	141971404(+)	`AAGCAC/TGAGCC`	14	--	ds500¹		0	--	--	--	--
rs191028272^1,2		--	141971425(+)	`ACAATA/GGTAGC`	14	--	ds500¹		0	--	--	--	--
rs182137182^1,2		--	141971460(+)	`GAAGAA/GAAAGT`	14	--	ds500¹		0	--	--	--	--
rs185262943^1,2		--	141971471(+)	`TTCACC/TTGAGT`	14	--	ds500¹		0	--	--	--	--
rs191156702^1,2		--	141971602(+)	`CCTTCA/GCATTC`	14	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGF1 (141971743 - 142077635 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for FGF1
8 CNVs: 93265 81064 64323 51582 38592 81063 93266 93263
4 Indels: 93268 93267 51583 93264
Human Gene Mutation Database (HGMD): FGF1

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing FGF1:

Oncogenes & Tumor Suppressor Genes 384HC

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF1

DNA2.0 Custom Variant and Variant Library Synthesis for FGF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGF1 for disorders           About GeneDecksing

OMIM gene information: 131220    OMIM disorders: --

20/98 diseases for FGF1 (see all 98):    About MalaCards

cleft lip/palate amyotrophic lateral sclerosis critical limb ischemia barrett's esophagus

intermittent claudication cleft lip squamous cell carcinoma bladder transitional cell carcinoma

lateral sclerosis transitional cell carcinoma chronic obstructive pulmonary disease hypophosphatemia

kaposi's sarcoma intracranial aneurysm oral squamous cell carcinoma acquired immunodeficiency syndrome

squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma cleft palate benign tumors

6 diseases from the University of Copenhagen DISEASES database for FGF1:

Cancer Bone disease Vascular disease Hypophosphatemia

Eye disease X-linked hypophosphatemia

10/94 Novoseek disease relationships for FGF1 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	48.6	12	9443020 (2), 8685603 (2), 15273729 (1), 7533902 (1) (see all 8)
tumors	38.8	114	9366526 (4), 7523040 (3), 9740144 (3), 11759058 (3) (see all 64)
glioblastoma	37.9	12	7680120 (2), 7544453 (2), 1938597 (1), 7678925 (1) (see all 6)
bladder carcinoma	31.3	8	8969864 (2), 15273729 (1), 11908679 (1), 1377428 (1) (see all 5)
diphtheria	26.9	17	9437495 (2), 1281450 (2), 7511061 (2), 10355293 (1) (see all 7)
peripheral ischemia	24.9	1	16389546 (1)
hiv encephalitis	24.7	2	15358178 (1)
leukemia nonlymphocytic acute	24.3	3	1717925 (1), 7514571 (1)
solid tumor	23.7	5	17273733 (1), 19082464 (1), 16741658 (1), 11602651 (1)
necrosis	20.4	35	1545152 (1), 8419185 (1), 8104340 (1), 10095201 (1) (see all 29)

Genetic Association Database (GAD): FGF1
Human Genome Epidemiology (HuGE) Navigator: FGF1 (20 documents)

Export disorders for FGF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FGF1 gene, integrated from 9 sources (see all 912):
(articles sorted by number of sources associating them with FGF1)

Utopia: connect your pdf to the dynamic
world of online information

Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. (PubMed id 3523756)^{1, 2, 3} Jaye M.... Drohan W.N. (1986)
Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. (PubMed id 1693186)^{1, 2, 9} Chiu I.M.... Lehtoma K. (1990)
The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. (PubMed id 7504343)^{1, 2, 9} Zhao X.M.... Miller G.G. (1993)
Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. (PubMed id 1717925)^{1, 2, 9} Wang W.P.... Chiu I.M. (1991)
An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. (PubMed id 1372643)^{1, 2, 9} Li Y.L....Turck E.J. (1992)
1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. (PubMed id 7521397)^{1, 2, 9} Pineda-Lucena A....Gimenez-Gallego G. (1994)
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PubMed id 11069186)^{1, 2, 9} Pellegrini L.... Blundell T.L. (2000)
Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog. (PubMed id 8950275)^{1, 2, 9} Pineda-Lucena A.... Gimenez-Gallego G. (1996)
The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. (PubMed id 18400376)^{1, 2, 9} Di Serio C....Tarantini F. (2008)
Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. (PubMed id 15358178)^{1, 4, 9} Yamagata H....Kondo I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2246	HGNC: 3665	AceView: FGF1	Ensembl:ENSG00000113578	euGenes: HUgn2246
ECgene: FGF1	Kegg: 2246	H-InvDB: FGF1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FGF1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf1/

Intellectual Property for FGF1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FGF1 gene:
Search GeneIP for patents involving FGF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

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FGF1 Gene

fibroblast growth factor 1 (acidic)

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FGF1 (Gene Symbol)
Fibroblast Growth Factor 1 (Acidic)
FGFA
ECGF
AFGF
ECGF-Beta
ECGFA
ECGFB
FGF-Alpha
GLIO703
HBGF1
Heparin-Binding Growth Factor 1
FGF-1
HBGF-1
Beta-Endothelial Cell Growth Factor
Endothelial Cell Growth Factor, Alpha
Endothelial Cell Growth Factor, Beta
Fibroblast Growth Factor 1
AFGF
Acidic Fibroblast Growth Factor
Endothelial Cell Growth Factor

Kaposi Sarcoma
dysplasia
Myocardial Ischemia
Vitreoretinopathy Proliferative
Atherosclerosis
Ischemia
Metaplasia
Breast Cancer
Neovascularization
primary tumor
AIDS
Adenocarcinoma
Carcinoma Transitional Cell
Cancer
Obstruction
ADENOCARCINOMA GASTRIC
INTESTINAL ISCHEMIA
GASTRIC CARCINOMA
Ovarian Cancer
Shock
RENAL DISEASE
Bronchoalveolar Lavage Fluid
Ulcer
Leiomyoma
Inflammation
Uterine leiomyoma
Chronic arthritis
immunodeficiency
Bladder Tumors
Hypertrophy
HIV encephalitis
PERIPHERAL ISCHEMIA
prostate cancer
Tumors
Cardiovascular Diseases
Pheochromocytoma
Metastasis
Necrosis
Glioblastoma
Fibroadenoma
Collagen fibril
Senile Plaques
Huntington Disease
Gastric Cancer
Barrett Esophagus
Leukemia Nonlymphocytic Acute
Neurodegenerative Diseases
Coronary Occlusion
Melanoma
Brain Tumors
Chondrosarcoma
BREAST CARCINOMA
Autoimmune Diseases
bladder cancer
Adenoma Follicular
Hyperplasia
inflammatory joint disease
Glioma
Liver Fibrosis
Astrocytoma
Carcinoma
INFARCT
Osteoarthritis
epithelial tumor
PROSTATE CARCINOMA
Leukemia
Alzheimers Disease
Osteosarcoma
Carcinoma Papillary
Adenoma Pleomorphic
HEPATOCELLULAR CARCINOMA
Arteriosclerosis
metastatic melanoma
Amyotrophic Lateral Sclerosis
Carcinoma Renal Cell
Pancreatic Cancer
chronic pancreatitis
Myocardial Infarction
Coronary Artery Disease
Diphtheria
Adenoma
benign prostatic hyperplasia
benign tumor
mesothelioma
solid tumor
Carcinoma Squamous Cell
restenosis
BLADDER CARCINOMA
Atrophy
Schwannoma
PANCREATIC CARCINOMA
Myelodysplastic Syndromes
Encephalitis
Arthritis

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FGF1 Gene

fibroblast growth factor 1 (acidic)

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