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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF1 Gene

protein-coding   GIFtS: 74
GCID: GC05M141953

Fibroblast Growth Factor 1 (Acidic)


(Previous symbol: FGFA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fibroblast Growth Factor 1 (Acidic)1 2     ECGFA2
FGFA1 2 3 5     ECGFB2
Heparin-Binding Growth Factor 11 2 3     FGF-alpha2
Endothelial Cell Growth Factor1 3     GLIO7032
ECGF2 3     HBGF12
FGF-12 3     Beta-Endothelial Cell Growth Factor2
HBGF-12 3     Endothelial Cell Growth Factor, Alpha2
alpha1     Endothelial Cell Growth Factor, Beta2
beta1     Fibroblast Growth Factor 12
AFGF2     aFGF3
ECGF-beta2     Acidic Fibroblast Growth Factor3

External Ids:    HGNC: 36651   Entrez Gene: 22462   Ensembl: ENSG000001135787   OMIM: 1312205   UniProtKB: P052303   
ORGUL members:         
NONCODE14:n334117 n333721 n407227 n340669      

Export aliases for FGF1 gene to outside databases

Previous GC identifers: GC05M141873 GC05M142555 GC05M142001 GC05M137120


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF1 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor.
It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be
involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been
described. (provided by RefSeq, Jan 2009)

GeneCards Summary for FGF1 Gene: 
FGF1 (fibroblast growth factor 1 (acidic)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with FGF1 include breast fibroadenoma, and critical limb ischemia, and among its related super-pathways are Regulation of actin cytoskeleton and Development FGF-family signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF2.

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell
differentiation and cell migration. Functions as potent mitogen in vitro

Gene Wiki entry for FGF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF1 gene promoter:
         PPAR-gamma1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FGF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3-q33.2

FGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M141953:  view genomic region     (about GC identifiers)

Start:
141,971,743 bp from pter      End:
142,077,635 bp from pter
Size:
105,893 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FGF1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230 (See protein sequence)
Recommended Name: Fibroblast growth factor 1 precursor  
Size: 155 amino acids; 17460 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth
factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as
coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent
multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with
S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP
seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1
Subcellular location: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a
cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a
non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity).
Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal
membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery,
involving proteins KPNA1 and KPNB1, as well as LRRC59
6/87 PDB 3D structures from and Proteopedia for FGF1 (see all 87):
1AXM (3D)        1DJS (3D)        1DZC (3D)        1DZD (3D)        1E0O (3D)        1EVT (3D)    
Secondary accessions: B2R5T0 D3DQF2 P07502 Q16588
Alternative splicing: 2 isoforms:  P05230-1   P05230-2   

Explore the universe of human proteins at neXtProt for FGF1: NX_P05230

Explore proteomics data for FGF1 at MOPED 

Post-translational modifications:

  • UniProtKB: In the nucleus, phosphorylated by PKC/PRKCD
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05230

  • FGF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF1 Protein Expression
    REFSEQ proteins (14 alternative transcripts): 
    NP_000791.1  NP_001138364.1  NP_001138406.1  NP_001138407.1  NP_001244134.1  NP_001244135.1  NP_001244136.1  NP_001244137.1  
    NP_001244138.1  NP_001244139.1  NP_001244140.1  NP_001244141.1  NP_149127.1  NP_149128.1  

    ENSEMBL proteins: 
     ENSP00000352329   ENSP00000367285   ENSP00000338548   ENSP00000354231   ENSP00000383969  
     ENSP00000404742   ENSP00000396195   ENSP00000378005   ENSP00000399458  
    Reactome Protein details: P05230
    Human Recombinant Protein Products for FGF1: 
    EMD Millipore Purified and/or Recombinant FGF1 Protein
    R&D Systems Recombinant & Natural Proteins for FGF1 (FGF acidic)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FGF1
    OriGene Protein Over-expression Lysate for FGF1
    OriGene MassSpec for FGF1 
    OriGene Custom Protein Services for FGF1
    GenScript Purified and Recombinant Proteins for FGF1
    Novus Biologicals FGF1 Proteins
    Novus Biologicals FGF1 Lysates
    Sino Biological Recombinant Protein for FGF1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FGF1
    Cloud-Clone Corp. Proteins for FGF1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA18400376
    GO:0005634nucleus ----
    GO:0005730nucleolus IEA--

    FGF1 for ontologies           About GeneDecksing



    FGF1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals FGF1 Antibodies
    Abcam antibodies for FGF1
    Cloud-Clone Corp. Antibodies for FGF1 
    ThermoFisher Antibodies for FGF1
    LSBio Antibodies in human, mouse, rat for FGF1 

    Assay Products for FGF1: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for FGF1 (FGF acidic)         (see all)
    GenScript Custom Assay Services for FGF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF1 
    Cloud-Clone Corp. CLIAs for FGF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P05230

    ProtoNet protein and cluster: P05230

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230
    Similarity: Belongs to the heparin-binding growth factors family


    FGF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF1_HUMAN, P05230
    Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell
    differentiation and cell migration. Functions as potent mitogen in vitro

         Genatlas biochemistry entry for FGF1:
    fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of
    synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly
    expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar
    cortex,also expressed in the retina (accessible to pharmacologic regulation)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI10830168
    GO:0005515protein binding IPI10618369
    GO:0008083growth factor activity IDA--
    GO:0008201heparin binding IDA--
    GO:0030544Hsp70 protein binding IEA--
         
    FGF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FGF1:
     Increased G1 DNA content  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf1):
     hematopoietic system  homeostasis/metabolism  nervous system  normal 

    FGF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgf1tm1Bas for FGF1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF1 

    miRNA
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    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF1 (see all 54):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidFGF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FGF1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FGF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FGF1 (see all 27)
    OriGene ORF clones in mouse, rat for FGF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): FGF1 (NM_001144934)
    Sino Biological Human cDNA Clone for FGF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF1
    Sirion Biotech Customized lentivirus for stable overexpression of FGF1 
                         Customized lentivirus expression plasmids for stable overexpression of FGF1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FGF1
    Search LifeMap BioReagents cell lines for FGF1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF1 About   (see all 37)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2Development FGF-family signaling
    Development FGF-family signaling0.63
    FGF Pathway0.38
    3FGFR2c ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR1c ligand binding and activation0.79
    SHC-mediated cascade0.79
    FGFR2 ligand binding and activation0.76
    FGFR2c ligand binding and activation0.79
    Signaling by FGFR2 mutants0.76
    FGFR1 ligand binding and activation0.79
    Activated point mutants of FGFR20.76
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FGF1
        Development FGF-family signaling

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF1 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FGF1
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for FGF1
        Development FGF-family signaling

    3 BioSystems Pathways for FGF1
        Regulation of Actin Cytoskeleton
    Integrated Pancreatic Cancer Pathway
    FGF signaling pathway


    5/61        Reactome Pathways for FGF1 (see all 61)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    5/7         Kegg Pathways  (Kegg details for FGF1) (see all 7):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer


    FGF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for FGF1 (P052301, 2, 3 ENSP000003385484) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218021, 2, 3, ENSP000004102944EBI-698068,EBI-1028658 MINT-25002 I2D: score=4 STRING: ENSP00000410294
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=2 
    ENSG00000224398P678703I2D: score=2 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001759organ induction IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007165signal transduction NAS3778488
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    FGF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF1

    1 HMDB Compound for FGF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    9 DrugBank Compounds for FGF1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Naphthalene Trisulfonate-- --target--17139284 17016423 10592235
    Pentosan Polysulfate-- 37300-21-3targetantagonist8867461 17071728 8946244
    Sucrose Octasulfate-- 57680-56-5target--17139284 17016423 10592235
    Formic AcidAminic acid (see all 5)64-18-6target--17139284 17016423
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423
    O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423
    5-AMINO-NAPHTALENE-2-MONOSULFONATE-- --target--10592235
    AmlexanoxAmlexanox [USAN:INN:JAN] (see all 3)68302-57-8targetinhibitor16300395
    PazopanibGW-786034 (see all 2)444731-52-6targetinhibitor23072642

    10/92 Novoseek inferred chemical compound relationships for FGF1 gene (see all 92)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 78.8 489 10413500 (10), 7638745 (8), 10664506 (8), 10226073 (8) (see all 99)
    amlexanox 75.2 25 20178375 (4), 18164517 (2), 16300395 (2), 9712836 (2) (see all 6)
    inositol hexasulfate 73.2 9 7521397 (3), 8950275 (2), 1721051 (1), 10848963 (1)
    sucrose octasulfate 73 23 7692970 (7), 7520817 (3), 8565003 (2), 19034645 (1) (see all 5)
    safrole oxide 72.8 3 15763947 (1), 11931706 (1), 13678651 (1)
    heparan sulfate 70.1 64 10362842 (5), 10673367 (5), 9516424 (4), 7537691 (3) (see all 24)
    tyrosine 59 81 11162655 (4), 7693700 (3), 9647656 (3), 10413500 (3) (see all 54)
    su5402 57.5 1 11146443 (1)
    amanitin 51.6 2 9003041 (1), 9406911 (1)
    vegf 51.2 85 9704334 (7), 14764221 (4), 10451491 (4), 11352499 (3) (see all 37)

    Search CenterWatch for drugs/clinical trials and news about FGF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF1 gene (14 alternative transcripts): 
    NM_000800.4  NM_001144892.2  NM_001144934.1  NM_001144935.1  NM_001257205.1  NM_001257206.1  NM_001257207.1  NM_001257208.1  
    NM_001257209.1  NM_001257210.1  NM_001257211.1  NM_001257212.1  NM_033136.3  NM_033137.2  

    Unigene Cluster for FGF1:

    Fibroblast growth factor 1 (acidic)
    Hs.483635  [show with all ESTs]
    Unigene Representative Sequence: NM_000800
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359370(uc011dbi.2 uc003lmm.3 uc003lmn.4 uc003lmp.4 uc003lmq.3 uc010jgj.3 uc003lmr.3 uc003lms.4 uc021yew.1)
    ENST00000378046 ENST00000337706 ENST00000360966 ENST00000489937 ENST00000407758
    ENST00000494344 ENST00000441680 ENST00000419524 ENST00000494579 ENST00000394496
    ENST00000411960
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF1 (see all 54):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidFGF1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for FGF1 (see all 27)
    OriGene ORF clones in mouse, rat for FGF1
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    GenScript: all cDNA clones in your preferred vector (see all 6): FGF1 (NM_001144934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF1
    Sirion Biotech Customized lentivirus for stable overexpression of FGF1 
                         Customized lentivirus expression plasmids for stable overexpression of FGF1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF1

    Additional mRNA sequence: 

    AK289762.1 AK312301.1 BC032697.1 DQ655917.2 L01485.1 L01487.1 M13361.1 M60515.1 
    M60516.1 M74028.1 S67291.1 S67292.1 S67294.1 X51943.1 X65778.1 X65779.1 

    14 DOTS entries:

    DT.75172191  DT.316852  DT.120822824  DT.100755318  DT.120822956  DT.316853  DT.99999797  DT.120822822 
    DT.95174755  DT.100649059  DT.120822823  DT.120822839  DT.120822945  DT.120822952 

    24/130 AceView cDNA sequences (see all 130):

    L01487 BX119756 BQ876462 F06068 BX444567 BM726629 X65779 M60516 
    NM_000800 BQ006675 AA348518 AA918107 CD171995 AI283639 CF127400 M60515 
    X65778 NM_033137 S67294 AI082417 S67292 NM_033136 BE464377 AI359575 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
    SP1:        -     -     -                 -     -     -     -     -     -     -     -     -                                                                     
    SP2:                                      -     -     -     -     -     -     -     -     -                                                                     
    SP3:                                      -     -     -     -     -           -     -     -                                                                     
    SP4:                                      -     -     -     -     -     -     -     -     -                                                                     
    SP5:                                      -     -     -     -     -     -     -     -     -                                                                     

    ExUns: 10h · 10i · 10j
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for FGF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF1 expression in normal human tissues (normalized intensities)      FGF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAGGGG
    FGF1 Expression
    About this image


    FGF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Dorsal Root Ganglion   
     
     Tooth
             visceral organ/oral region/upper jaw   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             sensory organ/eye/cornea   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   

    See FGF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF1

    SOURCE GeneReport for Unigene cluster: Hs.483635

    UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230
    Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and
    skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF1 (see all 8): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FGF1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf11 , 5 fibroblast growth factor 11, 5 90.54(n)1
    95.48(a)1
      18 (20.74 cM)5
    141641  NM_010197.31  NP_034327.11 
     388386735 
    chicken
    (Gallus gallus)
    Aves FGF11 fibroblast growth factor 1 (acidic) 79.78(n)
    90.32(a)
      396094  NM_205180.1  NP_990511.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF16
    Uncharacterized protein
    79(a)
    1 ↔ 1
    2(126713674-126793466)
    zebrafish
    (Danio rerio)
    Actinopterygii fgf1a1 fibroblast growth factor 1a 57.21(n)
    55.97(a)
      393733  NM_200760.1  NP_957054.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-7566
    Protein let-756
    10(a)
    1 → many
    III(6407129-6410018)


    ENSEMBL Gene Tree for FGF1 (if available)
    TreeFam Gene Tree for FGF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF1 gene
    FGF22  
    18/19 SIMAP similar genes for FGF1 using alignment to 6 protein entries:     FGF1_HUMAN (see all proteins) (see all similar genes):
    FGFA    fgf gene    FGF2    FGF16    FGF9    FGF20
    FGF12    FGF18    FGF13    KGFLP1    FGF11    FGF14
    FGF6    FGF7    FGF10    FGF5    FGF22    FGF3

    FGF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2509 SNPs in FGF1 are shown (see all 2509)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753787601,2
    C,F--141971249(+) TTAAAA/CTGATA 14 -- ds50011Minor allele frequency- C:0.07WA 118
    rs131790221,2
    C,F,H--141971281(+) AATCTA/GTAGCT 14 -- ds500132Minor allele frequency- G:0.38EA NS NA WA CSA 3090
    rs105699561,2
    C--141971362(+) AAATG-/TTTTTTT 14 -- ds50011Minor allele frequency- TT:0.00CSA 2
    rs1424837821,2
    C--141971362(+) AAATG-/TTTTTTT 14 -- ds50010--------
    rs562328361,2
    C--141971374(+) TTTTT-/T/T   
       T
    /TTT
    CAGGC
    28 -- ds5001 cds11NA 2
    rs172176671,2
    C,F--141971403(-) GCTCGT/AGCTTA 14 -- ds50012Minor allele frequency- A:0.02NS NA 106
    rs1863367161,2
    --141971404(+) AAGCAC/TGAGCC 14 -- ds50010--------
    rs1910282721,2
    --141971425(+) ACAATA/GGTAGC 14 -- ds50010--------
    rs1821371821,2
    --141971460(+) GAAGAA/GAAAGT 14 -- ds50010--------
    rs1852629431,2
    --141971471(+) TTCACC/TTGAGT 14 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF1 (141971743 - 142077635 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for FGF1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665244CNV Deletion23128226
    dgv1046e199CNV Deletion23128226
    esv2421733CNV Deletion20811451
    nsv514325CNV Loss21397061
    nsv882993CNV Loss21882294
    nsv823281CNV Loss20364138
    nsv525272CNV Loss19592680
    nsv517346CNV Loss19592680
    esv27821CNV Loss19812545
    nsv830510CNV Gain17160897


    Human Gene Mutation Database (HGMD): FGF1
    SABiosciences Cancer Mutation PCR Assays
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    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing FGF1
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 131220    OMIM disorders: --

    20/91 diseases for FGF1 (see all 91):    About MalaCards
    breast fibroadenoma    critical limb ischemia    endotheliitis    x-linked hypophosphatemia
    intermittent claudication    hypophosphatemia    ovarian epithelial cancer    ischemia
    leiomyoma    barrett's esophagus    arteriosclerosis    bladder transitional cell carcinoma
    pleomorphic adenoma    adenomyosis    kaposi's sarcoma    transitional cell carcinoma
    diphtheria    bladder carcinoma    benign tumors    encephalitis

    6 diseases from the University of Copenhagen DISEASES database for FGF1:
    Cancer     Bone disease     Vascular disease     Hypophosphatemia
    X-linked hypophosphatemia     Eye disease

    FGF1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for FGF1 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 48.6 12 9443020 (2), 8685603 (2), 15273729 (1), 7533902 (1) (see all 8)
    tumors 38.8 114 9366526 (4), 7523040 (3), 9740144 (3), 11759058 (3) (see all 64)
    glioblastoma 37.9 12 7680120 (2), 7544453 (2), 1938597 (1), 7678925 (1) (see all 6)
    bladder carcinoma 31.3 8 8969864 (2), 15273729 (1), 11908679 (1), 1377428 (1) (see all 5)
    diphtheria 26.9 17 9437495 (2), 1281450 (2), 7511061 (2), 10355293 (1) (see all 7)
    peripheral ischemia 24.9 1 16389546 (1)
    hiv encephalitis 24.7 2 15358178 (1)
    leukemia nonlymphocytic acute 24.3 3 1717925 (1), 7514571 (1)
    solid tumor 23.7 5 17273733 (1), 19082464 (1), 16741658 (1), 11602651 (1)
    necrosis 20.4 35 1545152 (1), 8419185 (1), 8104340 (1), 10095201 (1) (see all 29)

    Genetic Association Database (GAD): FGF1
    Human Genome Epidemiology (HuGE) Navigator: FGF1 (20 documents)

    Export disorders for FGF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF1 gene, integrated from 9 sources (see all 921):
    (articles sorted by number of sources associating them with FGF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. (PubMed id 3523756)1, 2, 3 Jaye M.... Drohan W.N. (1986)
    2. Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. (PubMed id 1693186)1, 2, 9 Chiu I.M.... Lehtoma K. (1990)
    3. The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. (PubMed id 7504343)1, 2, 9 Zhao X.M.... Miller G.G. (1993)
    4. Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. (PubMed id 1717925)1, 2, 9 Wang W.P.... Chiu I.M. (1991)
    5. An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. (PubMed id 1372643)1, 2, 9 Li Y.L....Turck E.J. (1992)
    6. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PubMed id 17204151)1, 4, 9 Butt C....Rahman P. (2007)
    7. 1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. (PubMed id 7521397)1, 2, 9 Pineda-Lucena A....Gimenez-Gallego G. (1994)
    8. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PubMed id 11069186)1, 2, 9 Pellegrini L.... Blundell T.L. (2000)
    9. Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog. (PubMed id 8950275)1, 2, 9 Pineda-Lucena A.... Gimenez-Gallego G. (1996)
    10. No association of the C>T polymorphism that is loc ated 1385 upstream from initial code of fibroblast growth factor 1 gene with Al zheimer's disease in Chinese. (PubMed id 20298684)1, 4, 9 Bian J.T....Zhang J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2246 HGNC: 3665 AceView: FGF1 Ensembl:ENSG00000113578 euGenes: HUgn2246
    ECgene: FGF1 Kegg: 2246 H-InvDB: FGF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF1 gene:
    Search GeneIP for patents involving FGF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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