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FGF1 Gene

protein-coding   GIFtS: 73
GCID: GC05M141953

Fibroblast Growth Factor 1 (Acidic)


(Previous symbol: FGFA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 1 (Acidic)1 2     ECGFA2
FGFA1 2 3 5     ECGFB2
Heparin-Binding Growth Factor 11 2 3     FGF-alpha2
Endothelial Cell Growth Factor1 3     GLIO7032
ECGF2 3     HBGF12
FGF-12 3     Beta-Endothelial Cell Growth Factor2
HBGF-12 3     Endothelial Cell Growth Factor, Alpha2
alpha1     Endothelial Cell Growth Factor, Beta2
beta1     Fibroblast Growth Factor 12
AFGF2     aFGF3
ECGF-beta2     Acidic Fibroblast Growth Factor3

External Ids:    HGNC: 36651   Entrez Gene: 22462   Ensembl: ENSG000001135787   OMIM: 1312205   UniProtKB: P052303   

Export aliases for FGF1 gene to outside databases

Previous GC identifers: GC05M141873 GC05M142555 GC05M142001 GC05M137120


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF1 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor.
It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be
involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been
described. (provided by RefSeq, Jan 2009)

GeneCards Summary for FGF1 Gene:
FGF1 (fibroblast growth factor 1 (acidic)) is a protein-coding gene. Diseases associated with FGF1 include breast fibroadenoma, and critical limb ischemia. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF2.

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell
differentiation and cell migration. Functions as potent mitogen in vitro

Gene Wiki entry for FGF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF1 gene promoter:
         PPAR-gamma1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FGF1 promoter sequence
   Search Chromatin IP Primers for FGF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3-q33.2

FGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M141953:  view genomic region     (about GC identifiers)

Start:
141,971,743 bp from pter      End:
142,077,635 bp from pter
Size:
105,893 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FGF1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230 (See protein sequence)
Recommended Name: Fibroblast growth factor 1 precursor  
Size: 155 amino acids; 17460 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth
factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as
coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent
multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with
S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP
seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1
Selected PDB 3D structures from and Proteopedia for FGF1 (see all 87):
1AXM (3D)        1DJS (3D)        1DZC (3D)        1DZD (3D)        1E0O (3D)        1EVT (3D)    
Secondary accessions: B2R5T0 D3DQF2 P07502 Q16588
Alternative splicing: 2 isoforms:  P05230-1   P05230-2   

Explore the universe of human proteins at neXtProt for FGF1: NX_P05230

Explore proteomics data for FGF1 at MOPED

Post-translational modifications: 

  • In the nucleus, phosphorylated by PKC/PRKCD1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (14 alternative transcripts): 
    NP_000791.1  NP_001138364.1  NP_001138406.1  NP_001138407.1  NP_001244134.1  NP_001244135.1  NP_001244136.1  NP_001244137.1  
    NP_001244138.1  NP_001244139.1  NP_001244140.1  NP_001244141.1  NP_149127.1  NP_149128.1  

    ENSEMBL proteins: 
     ENSP00000352329   ENSP00000367285   ENSP00000338548   ENSP00000354231   ENSP00000383969  
     ENSP00000404742   ENSP00000396195   ENSP00000378005   ENSP00000399458  
    Reactome Protein details: P05230

    FGF1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FGF1 Protein
    R&D Systems Recombinant & Natural Proteins for FGF1 (FGF acidic)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FGF1
    OriGene Protein Over-expression Lysate for FGF1
    OriGene MassSpec for FGF1
    OriGene Custom Protein Services for FGF1
    GenScript Purified and Recombinant Proteins for FGF1
    Novus Biologicals FGF1 Proteins
    Novus Biologicals FGF1 Lysates
    Sino Biological Recombinant Protein for FGF1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FGF1
    Cloud-Clone Corp. Proteins for FGF1

    FGF1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF1 (FGF acidic)
    Cell Signaling Technology (CST) Antibodies for FGF1 
    OriGene Antibodies for FGF1
    OriGene Custom Antibody Services for FGF1
    Novus Biologicals FGF1 Antibodies
    Abcam antibodies for FGF1
    Cloud-Clone Corp. Antibodies for FGF1
    ThermoFisher Antibodies for FGF1
    LSBio Antibodies in human, mouse, rat for FGF1

    FGF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FGF1
    R&D Systems ELISAs for FGF1 (FGF acidic)         (see all)
    GenScript Custom Assay Services for FGF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF1
    Cloud-Clone Corp. CLIAs for FGF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028210 FGF1
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry P05230

    ProtoNet protein and cluster: P05230

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230
    Similarity: Belongs to the heparin-binding growth factors family


    FGF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF1_HUMAN, P05230
    Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell
    differentiation and cell migration. Functions as potent mitogen in vitro

         Genatlas biochemistry entry for FGF1:
    fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of
    synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly
    expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar
    cortex,also expressed in the retina (accessible to pharmacologic regulation)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI10830168
    GO:0005515protein binding IPI10618369
    GO:0008083growth factor activity IDA--
    GO:0008201heparin binding IDA--
    GO:0030544Hsp70 protein binding IEA--
         
    FGF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FGF1:
     Increased G1 DNA content  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf1):
     hematopoietic system  homeostasis/metabolism  nervous system  normal 

    FGF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgf1tm1Bas for FGF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGF1:
    hsa-mir-7-5p (MIRT025666), hsa-mir-124-3p (MIRT022188)

    Block miRNA regulation of human, mouse, rat FGF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF1 (see all 54):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidFGF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF1
    Predesigned siRNA for gene silencing in human, mouse, rat FGF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF1

    Clone
    Products:
         
    OriGene clones in human, mouse for FGF1 (see all 32)
    OriGene ORF clones in mouse, rat for FGF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): FGF1 (NM_001144934)
    Sino Biological Human cDNA Clone for FGF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FGF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF1_HUMAN, P05230: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a
    cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a
    non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity).
    Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal
    membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery,
    involving proteins KPNA1 and KPNB1, as well as LRRC59
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    nucleus5
    cytoskeleton2
    endoplasmic reticulum2
    plasma membrane2
    endosome1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA18400376
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    FGF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF1 About   (see all 37)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR1b ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    FGFR2b ligand binding and activation0.00
    FRS2-mediated cascade0.70
    Activated point mutants of FGFR20.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF1 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FGF1
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for FGF1
        Development FGF-family signaling

    3 BioSystems Pathways for FGF1
        Regulation of Actin Cytoskeleton
    Integrated Pancreatic Cancer Pathway
    FGF signaling pathway


    Selected Reactome Pathways for FGF1 (see all 20)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    FGFR2b ligand binding and activation
    Negative regulation of FGFR signaling


    Selected Kegg Pathways  (Kegg details for FGF1) (see all 9):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Hippo signaling pathway


    FGF1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF1 (see all 8): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGF1 (P052301, 2, 3 ENSP000003385484) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218021, 2, 3, ENSP000004102944EBI-698068,EBI-1028658 MINT-25002 I2D: score=4 STRING: ENSP00000410294
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=2 
    ENSG00000224398P678703I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001759organ induction IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007165signal transduction NAS3778488
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    FGF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF1

    1 HMDB Compound for FGF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    9 DrugBank Compounds for FGF1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Naphthalene Trisulfonate-- --target--17139284 17016423 10592235
    Pentosan Polysulfate-- 37300-21-3targetantagonist8867461 17071728 8946244
    Sucrose Octasulfate-- 57680-56-5target--17139284 17016423 10592235
    Formic AcidAminic acid (see all 5)64-18-6target--17139284 17016423
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423
    O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423
    5-AMINO-NAPHTALENE-2-MONOSULFONATE-- --target--10592235
    AmlexanoxAmlexanox [USAN:INN:JAN] (see all 3)68302-57-8targetinhibitor16300395
    PazopanibGW-786034 (see all 2)444731-52-6targetinhibitor23072642

    Selected Novoseek inferred chemical compound relationships for FGF1 gene (see all 92)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 78.8 489 10413500 (10), 7638745 (8), 10664506 (8), 10226073 (8) (see all 99)
    amlexanox 75.2 25 20178375 (4), 18164517 (2), 16300395 (2), 9712836 (2) (see all 6)
    inositol hexasulfate 73.2 9 7521397 (3), 8950275 (2), 1721051 (1), 10848963 (1)
    sucrose octasulfate 73 23 7692970 (7), 7520817 (3), 8565003 (2), 19034645 (1) (see all 5)
    safrole oxide 72.8 3 15763947 (1), 11931706 (1), 13678651 (1)
    heparan sulfate 70.1 64 10362842 (5), 10673367 (5), 9516424 (4), 7537691 (3) (see all 24)
    tyrosine 59 81 11162655 (4), 7693700 (3), 9647656 (3), 10413500 (3) (see all 54)
    su5402 57.5 1 11146443 (1)
    amanitin 51.6 2 9003041 (1), 9406911 (1)
    vegf 51.2 85 9704334 (7), 14764221 (4), 10451491 (4), 11352499 (3) (see all 37)



    FGF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGF1 gene (14 alternative transcripts): 
    NM_000800.4  NM_001144892.2  NM_001144934.1  NM_001144935.1  NM_001257205.1  NM_001257206.1  NM_001257207.1  NM_001257208.1  
    NM_001257209.1  NM_001257210.1  NM_001257211.1  NM_001257212.1  NM_033136.3  NM_033137.2  

    Unigene Cluster for FGF1:

    Fibroblast growth factor 1 (acidic)
    Hs.483635  [show with all ESTs]
    Unigene Representative Sequence: NM_000800
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359370(uc011dbi.2 uc003lmm.3 uc003lmn.4 uc003lmp.4 uc003lmq.3 uc010jgj.3 uc003lmr.3 uc003lms.4 uc021yew.1)
    ENST00000378046 ENST00000337706 ENST00000360966 ENST00000489937 ENST00000407758
    ENST00000494344 ENST00000441680 ENST00000419524 ENST00000494579 ENST00000394496
    ENST00000411960
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FGF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF1 (see all 54):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidFGF1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FGF1
    Predesigned siRNA for gene silencing in human, mouse, rat FGF1
    Clone
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    OriGene clones in human, mouse for FGF1 (see all 32)
    OriGene ORF clones in mouse, rat for FGF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): FGF1 (NM_001144934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF1
    Primer
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    OriGene qPCR primer pairs and template standards for FGF1
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF1
      QuantiTect SYBR Green Assays in human, mouse, rat FGF1
      QuantiFast Probe-based Assays in human, mouse, rat FGF1

    Additional mRNA sequence: 

    AK289762.1 AK312301.1 BC032697.1 DQ655917.2 L01485.1 L01487.1 M13361.1 M60515.1 
    M60516.1 M74028.1 S67291.1 S67292.1 S67294.1 X51943.1 X65778.1 X65779.1 

    14 DOTS entries:

    DT.75172191  DT.316852  DT.120822824  DT.100755318  DT.120822956  DT.316853  DT.99999797  DT.120822822 
    DT.95174755  DT.100649059  DT.120822823  DT.120822839  DT.120822945  DT.120822952 

    Selected AceView cDNA sequences (see all 130):

    AA348518 NM_033137 F06068 AI283639 M74028 X65778 NM_000800 CD171995 
    S67292 M60516 S67294 N47796 AA857410 AI245781 BE464377 BX119756 
    AI082417 BQ876462 S67291 BQ006675 L01487 BX444567 CF127400 CD634782 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
    SP1:        -     -     -                 -     -     -     -     -     -     -     -     -                                                                     
    SP2:                                      -     -     -     -     -     -     -     -     -                                                                     
    SP3:                                      -     -     -     -     -           -     -     -                                                                     
    SP4:                                      -     -     -     -     -     -     -     -     -                                                                     
    SP5:                                      -     -     -     -     -     -     -     -     -                                                                     

    ExUns: 10h · 10i · 10j
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for FGF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAGGGG
    FGF1 Expression
    About this image


    FGF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 9 entries
             Early Ameloblasts Dental Enamel
             Dentin
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Midbrain tegmentum
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Metencephalon
    FGF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483635

    UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230
    Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and
    skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF1 (see all 8): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FGF1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for FGF1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf11 , 5 fibroblast growth factor 11, 5 90.54(n)1
    95.48(a)1
      18 (20.74 cM)5
    141641  NM_010197.31  NP_034327.11 
     388386735 
    chicken
    (Gallus gallus)
    Aves FGF11 fibroblast growth factor 1 (acidic) 79.78(n)
    90.32(a)
      396094  NM_205180.1  NP_990511.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF16
    fibroblast growth factor 1 (acidic)
    79(a)
    1 ↔ 1
    2(126713674-126793466)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgf11 fibroblast growth factor 1 (acidic) 69.25(n)
    76.13(a)
      100217324  NM_001142821.1  NP_001136293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf1a6
    fgf1b6
    fibroblast growth factor 1b
    54(a)
    51(a)
    many ↔ many
    many ↔ many
    14(24636180-24641905) ENSDARG00000017542
    21(42662924-42666251) ENSDARG00000042811
    fruit fly
    (Drosophila melanogaster)
    Insecta bnl6
    branchless
    6(a)
    1 → many
    3R(15619795-15662539)


    ENSEMBL Gene Tree for FGF1 (if available)
    TreeFam Gene Tree for FGF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF1 gene
    FGF22  
    Selected SIMAP similar genes for FGF1 using alignment to 6 protein entries:     FGF1_HUMAN (see all proteins) (see all similar genes):
    FGFA    fgf gene    FGF2    FGF16    FGF9    FGF20
    FGF12    FGF18    FGF13    KGFLP1    FGF11    FGF14
    FGF6    FGF7    FGF10    FGF5    FGF22    FGF3

    FGF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF1 (see all 2509)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753787601,2
    C,F--141971249(+) TTAAAA/CTGATA 14 -- ds50011Minor allele frequency- C:0.07WA 118
    rs131790221,2
    C,F,H--141971281(+) AATCTA/GTAGCT 14 -- ds500132Minor allele frequency- G:0.38EA NS NA WA CSA 3090
    rs105699561,2
    C--141971362(+) AAATG-/TTTTTTT 14 -- ds50011Minor allele frequency- TT:0.00CSA 2
    rs1424837821,2
    C--141971362(+) AAATG-/TTTTTTT 14 -- ds50010--------
    rs562328361,2
    C--141971374(+) TTTTT-/T/T   
       T
    /TTT
    CAGGC
    28 -- ds5001 cds11NA 2
    rs172176671,2
    C,F--141971403(-) GCTCGT/AGCTTA 14 -- ds50012Minor allele frequency- A:0.02NS NA 106
    rs1863367161,2
    --141971404(+) AAGCAC/TGAGCC 14 -- ds50010--------
    rs1910282721,2
    --141971425(+) ACAATA/GGTAGC 14 -- ds50010--------
    rs1821371821,2
    --141971460(+) GAAGAA/GAAAGT 14 -- ds50010--------
    rs1852629431,2
    --141971471(+) TTCACC/TTGAGT 14 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF1 (141971743 - 142077635 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FGF1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665244CNV Deletion23128226
    dgv1046e199CNV Deletion23128226
    esv2421733CNV Deletion20811451
    nsv514325CNV Loss21397061
    nsv882993CNV Loss21882294
    nsv823281CNV Loss20364138
    nsv525272CNV Loss19592680
    nsv517346CNV Loss19592680
    esv27821CNV Loss19812545
    nsv830510CNV Gain17160897

    Human Gene Mutation Database (HGMD): FGF1
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing FGF1:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing FGF1
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131220    OMIM disorders: --

    Selected diseases for FGF1 (see all 94):    
    About MalaCards
    breast fibroadenoma    critical limb ischemia    endotheliitis    intermittent claudication
    x-linked hypophosphatemia    ovarian epithelial cancer    hypophosphatemia    ischemia
    barrett esophagus/esophageal adenocarcinoma    leiomyoma    barrett's esophagus    arteriosclerosis
    adenomyosis    bladder transitional cell carcinoma    pleomorphic adenoma    diphtheria
    kaposi's sarcoma    bladder carcinoma    transitional cell carcinoma    encephalitis

    6 diseases from the University of Copenhagen DISEASES database for FGF1:
    Cancer     Bone disease     Vascular disease     Hypophosphatemia
    X-linked hypophosphatemia     Eye disease

    FGF1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FGF1 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 48.6 12 9443020 (2), 8685603 (2), 15273729 (1), 7533902 (1) (see all 8)
    tumors 38.8 114 9366526 (4), 7523040 (3), 9740144 (3), 11759058 (3) (see all 64)
    glioblastoma 37.9 12 7680120 (2), 7544453 (2), 1938597 (1), 7678925 (1) (see all 6)
    bladder carcinoma 31.3 8 8969864 (2), 15273729 (1), 11908679 (1), 1377428 (1) (see all 5)
    diphtheria 26.9 17 9437495 (2), 1281450 (2), 7511061 (2), 10355293 (1) (see all 7)
    peripheral ischemia 24.9 1 16389546 (1)
    hiv encephalitis 24.7 2 15358178 (1)
    leukemia nonlymphocytic acute 24.3 3 1717925 (1), 7514571 (1)
    solid tumor 23.7 5 17273733 (1), 19082464 (1), 16741658 (1), 11602651 (1)
    necrosis 20.4 35 1545152 (1), 8419185 (1), 8104340 (1), 10095201 (1) (see all 29)

    Genetic Association Database (GAD): FGF1
    Human Genome Epidemiology (HuGE) Navigator: FGF1 (20 documents)

    Export disorders for FGF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF1 gene, integrated from 10 sources (see all 922):
    (articles sorted by number of sources associating them with FGF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. (PubMed id 3523756)1, 2, 3 Jaye M.... Drohan W.N. (Science 1986)
    2. Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. (PubMed id 1693186)1, 2, 9 Chiu I.M.... Lehtoma K. (Oncogene 1990)
    3. The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. (PubMed id 7504343)1, 2, 9 Zhao X.M.... Miller G.G. (Transplantation 1993)
    4. Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. (PubMed id 1717925)1, 2, 9 Wang W.P.... Chiu I.M. (Oncogene 1991)
    5. An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. (PubMed id 1372643)1, 2, 9 Li Y.L....Turck E.J. (J. Exp. Med. 1992)
    6. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PubMed id 17204151)1, 4, 9 Butt C....Rahman P. (BMC Musculoskelet Disord 2007)
    7. 1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. (PubMed id 7521397)1, 2, 9 Pineda-Lucena A....Gimenez-Gallego G. (J. Mol. Biol. 1994)
    8. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PubMed id 11069186)1, 2, 9 Pellegrini L.... Blundell T.L. (Nature 2000)
    9. Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog. (PubMed id 8950275)1, 2, 9 Pineda-Lucena A.... Gimenez-Gallego G. (J. Mol. Biol. 1996)
    10. No association of the C&gt;T polymorphism that is located 1385 upstream from initial code of fibroblast growth factor 1 gene with Alzheimer's disease in Chinese. (PubMed id 20298684)1, 4, 9 Bian J.T....Zhang J.W. (Brain Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2246 HGNC: 3665 AceView: FGF1 Ensembl:ENSG00000113578 euGenes: HUgn2246
    ECgene: FGF1 Kegg: 2246 H-InvDB: FGF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF1 gene:
    Search GeneIP for patents involving FGF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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