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Aliases for FGF1 Gene

Aliases for FGF1 Gene

  • Fibroblast Growth Factor 1 2 3 5
  • Heparin-Binding Growth Factor 1 2 3 4
  • Endothelial Cell Growth Factor, Alpha 2 3
  • Endothelial Cell Growth Factor, Beta 2 3
  • Fibroblast Growth Factor 1 (Acidic) 2 3
  • HBGF-1 3 4
  • FGF-1 3 4
  • AFGF 3 4
  • FGFA 3 4
  • ECGF 3 4
  • Beta-Endothelial Cell Growth Factor 3
  • Acidic Fibroblast Growth Factor 4
  • Endothelial Cell Growth Factor 4
  • ECGF-Beta 3
  • FGF-Alpha 3
  • GLIO703 3
  • ECGFA 3
  • ECGFB 3
  • HBGF1 3

External Ids for FGF1 Gene

Previous HGNC Symbols for FGF1 Gene

  • FGFA

Previous GeneCards Identifiers for FGF1 Gene

  • GC05M141873
  • GC05M142001
  • GC05M141953
  • GC05M137120

Summaries for FGF1 Gene

Entrez Gene Summary for FGF1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for FGF1 Gene

FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Overnutrition and Sclerosteosis. Among its related pathways are RET signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.

UniProtKB/Swiss-Prot for FGF1 Gene

  • Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

Gene Wiki entry for FGF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF1 Gene

Genomics for FGF1 Gene

Regulatory Elements for FGF1 Gene

Enhancers for FGF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F142684 1 Ensembl ENCODE 37.4 +12.5 12543 3.0 PKNOX1 SAP130 ARID4B BMI1 ZIC2 ZNF335 ZNF316 ZFHX2 POLR2A SCRT2 FGF1 GC05M142697 GC05P142651
GH05F142673 1 Ensembl ENCODE 37.4 +22.9 22900 3.4 JUN INSM2 ZNF223 CEBPG ZEB1 FOSL1 GATA3 FOS MAFK ZBTB20 FGF1 GC05M142697 GC05P142651
GH05F142680 1.1 Ensembl ENCODE 31.3 +17.0 16967 1.7 PKNOX1 RAD21 RARA SCRT2 RCOR1 FOS SMARCC1 SP5 CEBPB ZEB2 FGF1 GC05M142697 GC05P142651
GH05F142668 0.9 Ensembl ENCODE 37.2 +27.4 27377 3.7 CEBPB USF2 MNT RAD21 ZNF121 RAD51 JUND POLR2A SMARCA4 FOXP2 FGF1 GC05P142651 GC05M142697
GH05F142612 1 FANTOM5 ENCODE 16.2 +84.4 84355 2.1 CTCF ZSCAN18 EBF1 ZNF2 RAD21 ZNF316 SMC3 ZNF391 MAFK ZNF654 FGF1 LOC101926941 SPRY4 GC05M142626 RPS12P10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGF1 Gene

Chromosome:
5
Start:
142,592,178 bp from pter
End:
142,698,070 bp from pter
Size:
105,893 bases
Orientation:
Minus strand

Genomic View for FGF1 Gene

Genes around FGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF1 Gene

Proteins for FGF1 Gene

  • Protein details for FGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05230-FGF1_HUMAN
    Recommended name:
    Fibroblast growth factor 1
    Protein Accession:
    P05230
    Secondary Accessions:
    • B2R5T0
    • D3DQF2
    • P07502
    • Q16588

    Protein attributes for FGF1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17460 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).

    Three dimensional structures from OCA and Proteopedia for FGF1 Gene

    Alternative splice isoforms for FGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF1 Gene

Post-translational modifications for FGF1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FGF1 (FGF1)

No data available for DME Specific Peptides for FGF1 Gene

Domains & Families for FGF1 Gene

Gene Families for FGF1 Gene

Graphical View of Domain Structure for InterPro Entry

P05230

UniProtKB/Swiss-Prot:

FGF1_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF1: view

Function for FGF1 Gene

Molecular function for FGF1 Gene

GENATLAS Biochemistry:
fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to pharmacologic regulation)
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

Gene Ontology (GO) - Molecular Function for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005102 receptor binding IEA --
GO:0005104 fibroblast growth factor receptor binding IEA,IPI 10830168
GO:0005178 integrin binding IDA 18441324
genes like me logo Genes that share ontologies with FGF1: view
genes like me logo Genes that share phenotypes with FGF1: view

Animal Models for FGF1 Gene

MGI Knock Outs for FGF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF1 Gene

Localization for FGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF1 Gene

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 18400376
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FGF1: view

Pathways & Interactions for FGF1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 Negative regulation of FGFR1 signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF1: view

SIGNOR curated interactions for FGF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IMP 18441324
GO:0001525 angiogenesis IEA --
GO:0001759 organ induction IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with FGF1: view

Drugs & Compounds for FGF1 Gene

(52) Drugs for FGF1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma inhibitor, Target, antagonist 0
Amlexanox Approved, Investigational Pharma Target, inhibitor Inhibitor of TBK1 and IKKeta; antiallergic agent 3
Heparin Approved, Investigational Pharma Antagonist 812,256
Pazopanib Approved Pharma Target, inhibitor VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Votrient Approved April 2012/ Approved October of 2009 Pharma 0

(49) Additional Compounds for FGF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF1: view

Transcripts for FGF1 Gene

Unigene Clusters for FGF1 Gene

Fibroblast growth factor 1 (acidic):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - -
SP16: - -

ExUns: 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FGF1 Gene

GeneLoc Exon Structure for
FGF1
ECgene alternative splicing isoforms for
FGF1

Expression for FGF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.6), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for FGF1 Gene

This gene is overexpressed in Spinal cord (24.3), Frontal cortex (11.4), Retina (10.3), and Brain (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGF1 Gene



Protein tissue co-expression partners for FGF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF1 Gene:

FGF1

SOURCE GeneReport for Unigene cluster for FGF1 Gene:

Hs.483635

mRNA Expression by UniProt/SwissProt for FGF1 Gene:

P05230-FGF1_HUMAN
Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with FGF1: view

Orthologs for FGF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF1 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia FGF1 34 35
  • 94.84 (n)
cow
(Bos Taurus)
Mammalia FGF1 34 35
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Fgf1 34 16 35
  • 90.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FGF1 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf1 34
  • 89.25 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF1 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF1 34 35
  • 79.78 (n)
lizard
(Anolis carolinensis)
Reptilia FGF1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf1 34
  • 69.25 (n)
zebrafish
(Danio rerio)
Actinopterygii fgf1a 35
  • 54 (a)
ManyToMany
fgf1b 35
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta bnl 35
  • 6 (a)
OneToMany
Species where no ortholog for FGF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF1 Gene

ENSEMBL:
Gene Tree for FGF1 (if available)
TreeFam:
Gene Tree for FGF1 (if available)

Paralogs for FGF1 Gene

Paralogs for FGF1 Gene

genes like me logo Genes that share paralogs with FGF1: view

Variants for FGF1 Gene

Sequence variations from dbSNP and Humsavar for FGF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036174 -- 142,657,843(+) GTATC(C/T)TGCCC intron-variant
rs10042957 -- 142,606,064(+) CTCAG(C/T)GCCAG intron-variant
rs10046003 -- 142,610,509(+) TGATC(C/T)TCTTC intron-variant
rs10050601 -- 142,691,346(+) gaacc(C/T)gggag intron-variant
rs10051247 -- 142,606,617(+) ATTCC(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF1 Gene

Variant ID Type Subtype PubMed ID
nsv830510 CNV gain 17160897
nsv823281 CNV loss 20364138
nsv525272 CNV loss 19592680
nsv517346 CNV loss 19592680
nsv514325 CNV loss 21397061
nsv441966 CNV loss 18776908
nsv1123991 CNV deletion 24896259
nsv1034911 CNV gain 25217958
nsv1031126 CNV gain 25217958
nsv1023306 CNV gain 25217958
esv3607008 CNV loss 21293372
esv3607007 CNV loss 21293372
esv3607006 CNV loss 21293372
esv3607005 CNV gain 21293372
esv3606999 CNV gain 21293372
esv3570474 CNV loss 25503493
esv27821 CNV loss 19812545
esv2760957 CNV loss 21179565
esv2665244 CNV deletion 23128226
esv2421733 CNV deletion 20811451
dgv1046e199 CNV deletion 23128226

Variation tolerance for FGF1 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF1 Gene

Human Gene Mutation Database (HGMD)
FGF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF1 Gene

Disorders for FGF1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FGF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
overnutrition
sclerosteosis
  • cortical hyperostosis with syndactyly
blount's disease
  • blount disease
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
vitreoretinopathy, neovascular inflammatory
  • proliferative vitreoretinopathy
- elite association - COSMIC cancer census association via MalaCards
Search FGF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF1

Genetic Association Database (GAD)
FGF1
Human Genome Epidemiology (HuGE) Navigator
FGF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF1
genes like me logo Genes that share disorders with FGF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF1 Gene

Publications for FGF1 Gene

  1. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. (PMID: 18441324) Mori S. … Takada Y. (J. Biol. Chem. 2008) 3 4 22 64
  2. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3- kinase/Akt intracellular signaling pathway. (PMID: 18400376) Di Serio C. … Tarantini F. (Cancer Lett. 2008) 3 4 22 64
  3. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PMID: 17204151) Butt C. … Rahman P. (BMC Musculoskelet Disord 2007) 3 22 46 64
  4. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 22 46 64
  5. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PMID: 11069186) Pellegrini L. … Blundell T.L. (Nature 2000) 3 4 22 64

Products for FGF1 Gene

Sources for FGF1 Gene

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