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FGF1 Gene

protein-coding GIFtS: 69

GC05M141953

fibroblast growth factor 1 (acidic)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FGFA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AFGF ^¹, ²
ECGF ^¹, ²
ECGF-beta ^¹, ², ³
ECGFA ^¹, ²
ECGFB ^¹, ²
FGF-alpha ^¹, ²
FGFA ^², ³, ⁵
GLIO703 ^¹, ²
HBGF-1 ^³
HBGF1 ^¹, ²
OTTHUMP00000066028 ^²
OTTHUMP00000066030 ^²
OTTHUMP00000066031 ^²
OTTHUMP00000174675 ^²
aFGF ^³

Descriptions
Acidic fibroblast growth factor ^³
Beta-endothelial cell growth factor ^³
endothelial cell growth factor, alpha ^²
endothelial cell growth factor, beta ^²
fibroblast growth factor 1 (acidic) ^²
heparin-binding growth factor 1 ^²

External Ids
HGNC: 3665¹
Entrez Gene: 2246²
UniProtKB: P05230³
Ensembl: ENSG00000113578⁷

Search outside databases for aliases for FGF1 gene

Previous GC identifers: GC05M141873 GC05M142555 GC05M142001

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FGF1:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF

family members possess broad mitogenic and cell survival activities, and are involved in a variety

of biological processes, including embryonic development, cell growth, morphogenesis, tissue

repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell

migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety

of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in

organogenesis. Multiple alternatively spliced variants encoding different isoforms have been

described. [provided by RefSeq]

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Function: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens

for a variety of cell types in vitro. There are differences in the tissue distribution and

concentration of these 2 growth factors

Gene Wiki entry for FGF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FGF1 gene

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3-q33.2

FGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M141953: (about GC identifiers)

Start:	141,951,927 bp from pter
End:	142,057,801 bp from pter
Size:	105,875 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230 (See protein sequence)

Recommended Name: Heparin-binding growth factor 1 precursor

Size: 155 amino acids; 17460 Da

Subunit: Monomer. Binds FGFR2. Forms a ternary complex containing 2 molecules each of FGFR2 and

FGF1 for 1 heparin molecule. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1

Miscellaneous: This protein binds heparin, although less strongly than does bFGF

PDB structures from and Proteopedia :

1AXM (3D)

1DJS (3D)

1DZC (3D)

1DZD (3D)

1E0O (3D)

1EVT (3D)

1HKN (3D)

1JQZ (3D)

1JT3 (3D)

1JT4 (3D)

1JT5 (3D)

1JT7 (3D)

1JTC (3D)

1JY0 (3D)

1K5U (3D)

1K5V (3D)

1M16 (3D)

1NZK (3D)

1P63 (3D)

1PZZ (3D)

1Q03 (3D)

1Q04 (3D)

1QCT (3D)

1RG8 (3D)

1RML (3D)

1RY7 (3D)

1YTO (3D)

1Z2V (3D)

1Z4S (3D)

2AFG (3D)

2AQZ (3D)

2AXM (3D)

2ERM (3D)

2HW9 (3D)

2HWA (3D)

2HWM (3D)

2HZ9 (3D)

2NTD (3D)

2Q9X (3D)

3B9U (3D)

3BA4 (3D)

3BA5 (3D)

3BA7 (3D)

3BAD (3D)

3BAG (3D)

3BAH (3D)

3BAO (3D)

3BAQ (3D)

3BAU (3D)

3BAV (3D)

3BB2 (3D)

3CQA (3D)

3CRG (3D)

3CRH (3D)

3CRI (3D)

3CU1 (3D)

Secondary accessions: P07502 Q16588

Alternative splicing: 2 isoforms: P05230-1 P05230-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_000791.1 NP_001138364.1 NP_001138406.1 NP_001138407.1 NP_149127.1 NP_149128.1

ENSEMBL proteins:

ENSP00000338548 ENSP00000367285 ENSP00000378002 ENSP00000383969 ENSP00000354231 ENSP00000384727

ENSP00000367286 ENSP00000352329 ENSP00000378005 ENSP00000384502

Human Recombinant Proteins

	Invitrogen human recombinant proteins for FGF1
	Millipore Purified and/or Recombinant FGF1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for FGF1 (FGF acidic)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FGF acidic, FGF1, FGF1 alpha)
	Human Recombinant Proteins from Abnova (FGF1)

OriGene Purified Recombinant Human Protein: FGF1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	EXP	1697263 8622701 9139660 11294897 16597617
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IEA	--

About this table

Antibodies for FGF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FGF1
	R&D Systems Antibodies for FGF1 (FGF acidic)
	Cell Signaling Technology (CST) Antibodies for FGF1 (Acidic FGF, FGF)
	Antibodies from Abcam (FGF acidic, FGF1, FGF1 alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FGF1)
	Novus Biologicals Antibodies for FGF1

Assays for FGF1:

	Invitrogen Assays for FGF1
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for FGF1 (FGF acidic) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05230

ProtoNet protein and cluster: P05230

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Similarity: Belongs to the heparin-binding growth factors family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FGF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_000800

Applied Biosystems Silencer® siRNAs for FGF1

Sigma-Aldrich siRNA and siRNA Panels for FGF1

Sigma-Aldrich shRNA Panels and shRNA for FGF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FGF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_000800
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_000800
untagged cDNA clones in CMV expression vector (see all 6): NM_000800

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000800

UniProtKB/Swiss-Prot: FGF1_HUMAN, P05230

Function: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens

for a variety of cell types in vitro. There are differences in the tissue distribution and

concentration of these 2 growth factors

Genatlas biochemistry entry for FGF1:

fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular

domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature

stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the

granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to

pharmacologic regulation)

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fgf1):

hematopoietic system

homeostasis/metabolism

nervous system

normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10618369 14732692
GO:0008083	growth factor activity	TAS	1693186
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for FGF1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Hepatic Fibrosis / Hepatic Stellate Cell Activation
FGF Signaling
Bladder Cancer Signaling
Clathrin-mediated Endocytosis
Actin Cytoskeleton Signaling

GeneDecks FGF1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FGF1

5/155 Interacting proteins for FGF1 (P05230^{1, 2} ENSP00000338548³) via UniProtKB, MINT, and/or STRING (see all 155 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR3	P22607¹, ENSP00000354170³	EBI-698068, EBI-348399 STRING (score=.999)
FGFR2	P21802¹^,², ENSP00000333090³	EBI-698068, EBI-1028658 MINT-25002 EBI-698068, EBI-1028658 MINT-25002 STRING (score=.999)
FGFR2	P21802¹^,², ENSP00000333090³	EBI-698068, EBI-1028658 MINT-25002 EBI-698068, EBI-1028658 MINT-25002 STRING (score=.999)
FGFR2	P21802¹^,², ENSP00000333090³	EBI-698068, EBI-1028658 MINT-25002 EBI-698068, EBI-1028658 MINT-25002 STRING (score=.999)
FGFR1	ENSP00000311337³	STRING (score=.999)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001759	induction of an organ	IEA	--
GO:0007165	signal transduction	NAS	3778488
GO:0007275	multicellular organismal development	TAS	10903182
GO:0008283	cell proliferation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FGF1
10/46 Novoseek chemical compound relationships for FGF1 gene (see all 46 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inositol hexasulfate	73.96	9	7521397 (3), 8950275 (2), 1721051 (1), 10848963 (1)
safrole oxide	73.08	3	15763947 (1), 11931706 (1), 13678651 (1)
heparan sulfate	69.33	64	10362842 (5), 10673367 (5), 9516424 (4), 7537691 (3) (see all 24)
tyrosine	59.07	79	11162655 (4), 7693700 (3), 9647656 (3), 10413500 (3) (see all 52)
su5402	58.95	1	11146443 (1)
amanitin	52.66	2	9003041 (1), 9406911 (1)
chlorate	49.00	7	10673367 (4), 7528211 (1), 9208230 (1), 10362842 (1)
sodium chlorate	48.99	1	7528211 (1)
tetrathiomolybdate	46.15	2	17643421 (1)
thymidine	46.15	16	1375939 (1), 7561097 (1), 11037874 (1), 19090149 (1) (see all 13)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FGF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_000800

Sigma-Aldrich siRNA and siRNA Panels for FGF1

Sigma-Aldrich shRNA Panels and shRNA for FGF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000800 NM_033136 NM_033137

REFSEQ mRNAs for FGF1 gene (6 alternative transcripts):

NM_000800.3 NM_001144892.1 NM_001144934.1 NM_001144935.1 NM_033136.2 NM_033137.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000800 NM_033136 NM_033137

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_000800
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_000800
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_000800

Additional cDNA sequence:

AK289762.1 AK312301.1 BC032697.1 DQ655917.2 DQ655918.2 L01485.1 L01487.1 M13361.1

M60515.1 M60516.1 M74028.1 S67291.1 S67292.1 S67294.1 X51943.1 X65778.1

X65779.1

15 DOTS entries:

DT.75172191 DT.316852 DT.120822824 DT.100755318 DT.120822822 DT.120822956 DT.316853 DT.99999797

DT.95174755 DT.100649059 DT.120822823 DT.120822830 DT.120822839 DT.120822945 DT.120822952

24/130 AceView cDNA sequences (see all 130 ):

AA857410 BX444567 M74028 S67292 AI082417 BE464377 S67294 M60516

AI245781 N47796 BX119756 F06068 CD171995 BQ006675 CD634782 AI283639

AI359575 AA348518 BQ876462 NM_000800 S67291 X65778 X65779 L01487

highest scoring ESTs for FGF1:

BG995253 M74028 AA015793 BG700150 BG706412 BI550213 BI598390 BI598882 BI753845 BM809005

Unigene Cluster for FGF1:

Fibroblast growth factor 1 (acidic)

Hs.483635 [show with all ESTs]

Unigene Representative Sequence: NM_033136

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 (see all 16 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f	·	10g	·
SP1:			-		-		-						-		-		-		-		-		-		-		-		-
SP2:													-		-		-		-		-		-		-		-		-
SP3:													-		-		-		-		-				-		-		-
SP4:													-		-		-		-		-		-		-		-		-
SP5:													-		-		-		-		-		-		-		-		-

ExUns:	10h	·	10i	·	10j
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for FGF1

10 Ensembl transcripts including schematic representations:

ENST00000337706 ENST00000378046 ENST00000394493 ENST00000407758 ENST00000360966 ENST00000405304

ENST00000378047 ENST00000359370 ENST00000394496 ENST00000403113

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FGF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FGF1

¹ / ² / ³

6 probe-sets matching FGF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
996_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X59065	0.20	1.00	0.72	1
205117_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X59065	0.20	1.00	0.72	1
208240_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013394	0.20	1.00	0.72	1
205117_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208240_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552721_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FGF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGAAGGGG

SOURCE GeneReport for Unigene cluster: Hs.483635
Expression variation in blood from EXPOLDB for FGF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FGF1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FGF1¹	--	fibroblast growth factor 1 (acidic)	94.84(n) 98.71(a)	607724 XM_844181.1 XP_849274.1
chimpanzee (Pan troglodytes)	FGF1¹	--	fibroblast growth factor 1 (acidic)	99.35(n) 100(a)	462158 XM_518007.2 XP_518007.1
cow (Bos taurus)	FGF1¹	--	fibroblast growth factor 1 (acidic)	91.4(n) 92.26(a)	281160 NM_174055.2 NP_776480.1
rat (Rattus norvegicus)	Fgf1¹	--	fibroblast growth factor 1	89.25(n) 95.48(a)	25317 NM_012846.1 NP_036978.1
mouse (Mus musculus)	Fgf1^{1, 5}	18 (19.00 cM)⁵	fibroblast growth factor 1^{1, 5}	90.54(n)¹ 95.48(a)¹	14164¹ NM_010197.3¹ NP_034327.1¹ AF012926⁵ AF067190⁵ (see all 20)

About this table Species with no ortholog for FGF1

ENSEMBL Gene Tree for FGF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FGF1 gene

FGF3² FGF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/780 NCBI SNPs in FGF1 are shown (see all 780 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 264)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs34000^1,2	A,C,F,H,O	141953685(-)	`AGACCG/ATTTGT`	3	--	ut3¹		8	EU EA WA NS NA	738
	rs34002^1,2	A,C,F,H,O	141954756(-)	`CCCTCA/CATGCA`	3	--	ut3¹		17	EA NA EU WA NS	1198
	rs33999^1,2	A,C,F,H,O	141953533(-)	`TGTATG/CTTTTA`	3	--	ut3¹		9	MN EU EA WA NS NA	922
	rs34001^1,2	A,C,F,H,O	141953783(-)	`TAAGAG/TGCTTT`	3	--	ut3¹		13	EU EA WA NS NA	1230
	rs2278688^1,2	A,C,F,H,O	141954266(-)	`ATGTGC/GATCTG`	3	--	ut3¹ ese³		16	EA NS EU WA NA	2746
	rs10055258^1,2	A,C,F,H	141952850(+)	`ATCTCC/TGAAAT`	3	--	ng5¹ ese³		11	NS EU EA WA	1250
	rs4912868^1,2	A,C,F,H	141952897(+)	`AATTTT/CCCTTG`	3	--	ng5¹		19	EA NS NA EU WA	1884
	rs17099029^1,2	C,F,H	141954717(+)	`TTAGCC/TGACCC`	3	--	ut3¹		18	NS EU EA WA NA	1818
	rs11955552^1,2	C,F,H	142047175(+)	`TCACGG/AATAAG`	3	--	ng3¹		14	NS NA EU EA WA	1380
	rs17099249^1,2	C,F,H	142046583(+)	`TCCCCG/ATTGGA`	3	--	ng3¹		8	NS EU EA WA NA	738

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HapMap Linkage Disequilibrium images for FGF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 131220

10/95 Novoseek disease relationships for FGF1 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	50.31	12	9443020 (2), 8685603 (2), 15273729 (1), 7533902 (1) (see all 8)
tumors	38.28	107	9366526 (4), 7523040 (3), 9740144 (3), 11759058 (3) (see all 59)
glioblastoma	36.59	12	7680120 (2), 7544453 (2), 1938597 (1), 7678925 (1) (see all 6)
bladder carcinoma	32.37	8	8969864 (2), 15273729 (1), 11908679 (1), 1377428 (1) (see all 5)
diphtheria	28.28	17	9437495 (2), 1281450 (2), 7511061 (2), 10355293 (1) (see all 7)
peripheral ischemia	26.37	1	16389546 (1)
solid tumor	25.64	5	17273733 (1), 19082464 (1), 16741658 (1), 11602651 (1)
hiv encephalitis	25.46	2	15358178 (1)
leukemia nonlymphocytic acute	24.82	3	1717925 (1), 7514571 (1)
necrosis	22.18	35	1545152 (1), 8419185 (1), 8104340 (1), 10095201 (1) (see all 29)

About this table

Human Gene Mutation Database: FGF1
Genetic Association Database: FGF1
Human Genome Epidemiology Navigator: FGF1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/780 PubMed articles for FGF1 gene (see all 780 ):

Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. (PubMed id 3523756)^{2, 3, 4} Jaye M....Drohan W.N. (1986)
Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. (PubMed id 1693186)^{1, 3, 4} Chiu I.M.... Lehtoma K. (1990)
The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. (PubMed id 7504343)^{1, 3, 4} Zhao X.M.... Miller G.G. (1993)
Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. (PubMed id 1717925)^{1, 3, 4} Wang W.P.... Chiu I.M. (1991)
An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. (PubMed id 1372643)^{1, 3, 4} Li Y.L....Turck E.J. (1992)
1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. (PubMed id 7521397)^{1, 3, 4} Pineda-Lucena A....Gimenez-Gallego G. (1994)
Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog. (PubMed id 8950275)^{1, 3, 4} Pineda-Lucena A.... Gimenez-Gallego G. (1996)
Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. (PubMed id 15358178)^{1, 3, 6} Yamagata H....Kondo I. (2004)
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PubMed id 11069186)^{1, 3, 4} Pellegrini L.... Blundell T.L. (2000)
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. (PubMed id 10830168)^{1, 3, 4} Plotnikov A.N.... Mohammadi M. (2000)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2246	HGNC: 3665	AceView: FGF1	Ensembl:ENSG00000113578	euGenes: HUgn2246
ECgene: FGF1	H-InvDB: FGF1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for FGF1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf1/

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Antibodies & Assays for FGF1 (Acidic FGF, FGF)

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Antibodies for FGF1

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FGF1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for FGF1

Summaries
for FGF1

Genomic Location
for FGF1

Proteins
for FGF1

Protein Domains/
Families
for FGF1

Gene Function
for FGF1

Pathways & Interactions
for FGF1

Drugs & Compounds
for FGF1

Transcripts
for FGF1

Expression
for FGF1

Orthologs
for FGF1

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for FGF1

SNPs/Variants
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Disorders & Mutations
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Medical News
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FGF1 (Gene Symbol)
AFGF
ECGF
ECGF-beta
ECGFA
ECGFB
FGF-alpha
FGFA
GLIO703
HBGF-1
HBGF1
OTTHUMP00000066028
OTTHUMP00000066030
OTTHUMP00000066031
OTTHUMP00000174675
aFGF
Acidic fibroblast growth factor
Beta-endothelial cell growth factor
endothelial cell growth factor, alpha
endothelial cell growth factor, beta
fibroblast growth factor 1 (acidic)
heparin-binding growth factor 1

FGF1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor FGF1

Summariesfor FGF1

Genomic Locationfor FGF1

Proteinsfor FGF1

Protein Domains/Familiesfor FGF1

Gene Functionfor FGF1

Pathways & Interactionsfor FGF1

Drugs & Compoundsfor FGF1

Transcriptsfor FGF1

Expression for FGF1

Orthologsfor FGF1

Paralogsfor FGF1

SNPs/Variantsfor FGF1

Disorders & Mutationsfor FGF1

Medical Newsfor FGF1

Publicationsfor FGF1

Search for FGF1

Genome Databases showing FGF1

Other Databases showing FGF1

Specialized Databases showing FGF1

Licensable Technologiesfor FGF1

Servicesfor FGF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FGF1

Summaries
for FGF1

Genomic Location
for FGF1

Proteins
for FGF1

Protein Domains/
Families
for FGF1

Gene Function
for FGF1

Pathways & Interactions
for FGF1

Drugs & Compounds
for FGF1

Transcripts
for FGF1

Expression
for FGF1

Orthologs
for FGF1

Paralogs
for FGF1

SNPs/Variants
for FGF1

Disorders & Mutations
for FGF1

Medical News
for FGF1

Publications
for FGF1

Licensable Technologies
for FGF1

Services
for FGF1