Aliases for FGF1 Gene
Aliases for FGF1 Gene
External Ids for FGF1 Gene
- HGNC: 3665
- Entrez Gene: 2246
- Ensembl: ENSG00000113578
- OMIM: 131220
- UniProtKB: P05230
Previous HGNC Symbols for FGF1 Gene
- FGFA
Previous GeneCards Identifiers for FGF1 Gene
- GC05M141873
- GC05M142001
- GC05M141953
- GC05M137120
Summaries for FGF1 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for FGF1 Gene
FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Overnutrition and Blount's Disease. Among its related pathways are GPCR Pathway and MAPK-Erk Pathway. GO annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.
UniProtKB/Swiss-Prot for FGF1 Gene
-
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF1 Gene
Genomics for FGF1 Gene
Regulatory Elements for FGF1 Gene
Enhancers for FGF1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G142673 | 1.3 | Ensembl ENCODE dbSUPER | 37.5 | +22.9 | 22900 | 3.4 | JUN ETV1 ZNF223 INSM2 CEBPG ZEB1 FOSL1 GATA3 ZSCAN5C FOS | FGF1 GC05M142697 GC05P142651 |
| GH05G142684 | 1.3 | Ensembl ENCODE dbSUPER | 37.4 | +12.5 | 12543 | 3.0 | PKNOX1 MXI1 FOXA2 SAP130 ZSCAN4 ARID4B BMI1 ZIC2 RAD21 ZNF335 | FGF1 GC05M142697 GC05P142651 |
| GH05G142668 | 1.2 | Ensembl ENCODE dbSUPER | 37.2 | +27.4 | 27377 | 3.7 | CTCF USF2 CEBPB MNT RAD21 ZNF121 RAD51 JUND POLR2A SMARCA4 | FGF1 GC05P142651 GC05M142697 |
| GH05G142680 | 1.4 | Ensembl ENCODE dbSUPER | 31.3 | +17.0 | 16967 | 1.7 | PKNOX1 FOXA2 RAD21 RARA SCRT2 RCOR1 FOS SMARCC1 SP5 CEBPB | FGF1 GC05M142697 GC05P142651 |
| GH05G142624 | 1.1 | Ensembl ENCODE dbSUPER | 14.8 | +72.3 | 72318 | 2.2 | ETV1 MAFG ELF4 ZNF662 NR2F2 GABPA ZNF316 GATA3 NFE2 NFE2L2 | FGF1 SPRY4-AS1 GC05M142626 RPS12P10 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGF1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FGF1 gene promoter:
Regulatory Element Products
Genomic Location for FGF1 Gene
- Chromosome:
- 5
- Start:
- 142,592,178 bp from pter
- End:
- 142,698,070 bp from pter
- Size:
- 105,893 bases
- Orientation:
- Minus strand
Genomic View for FGF1 Gene
Genes around FGF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
FGF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF1 Gene
Proteins for FGF1 Gene
-
Protein details for FGF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05230-FGF1_HUMAN
- Recommended name:
- Fibroblast growth factor 1
- Protein Accession:
- P05230
- B2R5T0
- D3DQF2
- P07502
- Q16588
Protein attributes for FGF1 Gene
- Size:
- 155 amino acids
- Molecular mass:
- 17460 Da
- Quaternary structure:
-
- Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).
Three dimensional structures from OCA and Proteopedia for FGF1 Gene
Protein Expression for FGF1 Gene
Post-translational modifications for FGF1 Gene
- In the nucleus, phosphorylated by PKC/PRKCD.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FGF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGF1 (FGF acidic)
- Cell Signaling Technology (CST) Antibodies for FGF1 (FGF1)
-
Custom Antibody ServicesOriGene Antibodies for FGF1
- Novus Biologicals Antibodies for FGF1
-
Abcam antibodies for FGF1
-
Cloud-Clone Corp. Antibodies for FGF1
- Invitrogen Antibodies for FGF1
- antibodies-online Antibodies for FGF1: See all 196
- GeneTex FGF1 antibody for FGF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF1
Protein Products
- EMD Millipore Purified and/or Recombinant FGF1 Protein
- R&D Systems Proteins and Enzymes for FGF1 (FGF acidic)
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF1
- Origene Custom Protein Services for FGF1
- Sino Biological Recombinant Proteins for FGF1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for FGF1
-
Cloud-Clone Corp. Proteins for FGF1
- antibodies-online Proteins for FGF1: See all 134
- Search antibodies-online for peptides
- GeneTex Proteins for FGF1
-
Abcam proteins for FGF1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for FGF1 (FGF acidic)
- antibodies-online Kits for FGF1: See all 86
No data available for DME Specific Peptides for FGF1 Gene
Domains & Families for FGF1 Gene
Gene Families for FGF1 Gene
- HGNC:
Protein Domains for FGF1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF1 Gene
Graphical View of Domain Structure for InterPro Entry
P05230- Family:
-
- Belongs to the heparin-binding growth factors family.
Function for FGF1 Gene
Molecular function for FGF1 Gene
- GENATLAS Biochemistry:
- fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to pharmacologic regulation)
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005104 | fibroblast growth factor receptor binding | IPI,IMP | 10830168 |
| GO:0005178 | integrin binding | IDA | 18441324 |
| GO:0005515 | protein binding | IPI | 10618369 |
Phenotypes for FGF1 Gene
- MGI mutant phenotypes for FGF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FGF1:
Animal Models for FGF1 Gene
- MGI Knock Outs for FGF1:
-
- Fgf1 tm1Bas
Animal Model Products
-
Taconic Biosciences Mouse Models for FGF1
-
ViGene Biosciences lentiviral particle packaged cDNA for FGF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
- Search ViGene Biosciences for FGF1
CRISPR Products
-
OriGene CRISPR knockouts for FGF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF1
- GenScript: Design CRISPR guide RNA sequences for FGF1
miRNA for FGF1 Gene
- miRTarBase miRNAs that target FGF1
-
- hsa-mir-124-3p (MIRT022188)
- hsa-mir-7-5p (MIRT025666)
- hsa-mir-943 (MIRT446182)
- hsa-mir-4439 (MIRT446183)
- hsa-mir-3136-5p (MIRT446184)
- hsa-mir-526b-5p (MIRT446185)
- hsa-mir-6857-3p (MIRT446186)
- hsa-mir-6855-3p (MIRT446187)
- hsa-mir-4513 (MIRT446188)
- hsa-mir-6069 (MIRT710277)
- hsa-mir-6728-3p (MIRT710278)
- hsa-mir-186-3p (MIRT710279)
- hsa-mir-6877-3p (MIRT710280)
- hsa-mir-6819-3p (MIRT710281)
- hsa-mir-7109-3p (MIRT710282)
- hsa-mir-4753-3p (MIRT717728)
- hsa-mir-302d-5p (MIRT717729)
- hsa-mir-302b-5p (MIRT717730)
- hsa-mir-130b-5p (MIRT717731)
- hsa-mir-589-3p (MIRT717732)
- hsa-mir-500b-3p (MIRT717733)
- hsa-mir-4773 (MIRT717734)
- hsa-mir-1912 (MIRT717735)
- hsa-mir-1295b-5p (MIRT717736)
miRNA Products
- Search ViGene Biosciences for FGF1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FGF1
- Browse OriGene Inhibitory RNA Products For FGF1
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
Clone Products
-
OriGene ORF clones in human for FGF1
- RG214005
- RC214005L2
- RC214005L1
- RC214005
- RG219380
- RC219380L2
- RC219380L1
- RC219380
- RG231871
- RC231871
- RG231870
- RC231870
- RG231881
- RC231881
- RG231880
- RC231880
- RG231879
- RC231879
- RG231878
- RC231878
- RG231869
- RC231869
- RG231877
- RC231877
- RG227797
- RC227797L2
- RC227797L1
- RC227797
- RG227790
- RC227790L2
- RC227790L1
- RC227790
- RG227317
- RC227317L2
- RC227317L1
- RC227317
- RG207434
- RC207434L2
- RC207434L1
- RC207434
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGF1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FGF1
Cell Line Products
-
Horizon Cell Lines for FGF1
-
ViGene Biosciences adenoviral particle packaged cDNA for FGF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12331) for FGF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF1 Gene
Localization for FGF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF1 Gene
- Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005615 | extracellular space | IDA | 18400376 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for FGF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 4 | Negative regulation of FGFR1 signaling | ||
| 5 | GPCR Pathway |
.73
.62
|
.55
|
Pathways by source for FGF1 Gene
3 Sino Biological pathways for FGF1 Gene
2 Cell Signaling Technology pathways for FGF1 Gene
4 BioSystems pathways for FGF1 Gene
111 Reactome pathways for FGF1 Gene
1 PharmGKB pathway for FGF1 Gene
9 KEGG pathways for FGF1 Gene
1 GeneGo (Thomson Reuters) pathway for FGF1 Gene
Interacting Proteins for FGF1 Gene
Selected Interacting proteins:
P05230-FGF1_HUMAN
ENSP00000338548
for FGF1 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | IMP | 18441324 |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001759 | organ induction | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Drugs & Compounds for FGF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pentosan Polysulfate | Approved | Pharma | inhibitor, Target, antagonist | 0 | ||
| Amlexanox | Approved, Investigational | Pharma | Target, inhibitor | Inhibitor of TBK1 and IKKeta; antiallergic agent | 3 | |
| Heparin | Approved, Investigational | Pharma | Antagonist | 848,265 | ||
| Pazopanib | Approved | Pharma | Target, inhibitor | VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Votrient | Approved April 2012/ Approved October of 2009 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FGF1 Gene
mRNA/cDNA for FGF1 Gene
- (16) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (130) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF1
- GenScript: Design CRISPR guide RNA sequences for FGF1
miRNA Products
- Search ViGene Biosciences for FGF1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FGF1
- Browse OriGene Inhibitory RNA Products For FGF1
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
Clone Products
-
OriGene ORF clones in human for FGF1
- RG214005
- RC214005L2
- RC214005L1
- RC214005
- RG219380
- RC219380L2
- RC219380L1
- RC219380
- RG231871
- RC231871
- RG231870
- RC231870
- RG231881
- RC231881
- RG231880
- RC231880
- RG231879
- RC231879
- RG231878
- RC231878
- RG231869
- RC231869
- RG231877
- RC231877
- RG227797
- RC227797L2
- RC227797L1
- RC227797
- RG227790
- RC227790L2
- RC227790L1
- RC227790
- RG227317
- RC227317L2
- RC227317L1
- RC227317
- RG207434
- RC207434L2
- RC207434L1
- RC207434
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGF1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FGF1
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12331) for FGF1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - |
| ExUns: | 10h | · | 10i | · | 10j |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: | |||||
| SP14: | |||||
| SP15: | |||||
| SP16: |
Expression for FGF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Dental Placode Cells Dental Placode
- Dental Papilla Cells Dental Papilla
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
- Pituitary Gland
- Cerebellum
- Deep Cerebellar Nucleus
- Midbrain tegmentum
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Neurons
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Endothelium (Cardiovascular System)
- Pericytes Microvessels
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Bone (Muscoskeletal System)
- Presumptive Suture Cells Rostral Sutures
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for FGF1 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.6), and Brain - Hypothalamus (x4.0).
This gene is overexpressed in Spinal cord (24.3), Frontal cortex (11.4), Retina (10.3), and Brain (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGF1 Gene:
FGF1SOURCE GeneReport for Unigene cluster for FGF1 Gene:
Hs.483635mRNA Expression by UniProt/SwissProt for FGF1 Gene:
P05230-FGF1_HUMAN
Tissue specificity:
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for FGF1 Gene
- Nervous system(5)
- Liver(4.4)
- Heart(3.3)
- Muscle(3.1)
- Eye(2.7)
- Kidney(2.7)
Primer Products
-
OriGene qPCR primer pairs for FGF1
-
OriGene qPCR primer pairs and template standards for FGF1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF1 Gene
Orthologs for FGF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGF1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGF1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGF1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgf1 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGF1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fgf1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGF1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGF1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGF1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgf1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgf1a 35 |
|
ManyToMany | |
| fgf1b 35 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | bnl 35 |
|
OneToMany |
- Species where no ortholog for FGF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGF1 Gene
(19) SIMAP similar genes for FGF1 Gene using alignment to 6 proteins:
Variants for FGF1 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033172 | -- | 142,616,532(+) | GCAGA(C/G)TTTAC | intron-variant | |
| rs1000048145 | -- | 142,602,377(+) | TCACC(A/C)TGTTG | intron-variant | |
| rs1000078835 | -- | 142,602,685(+) | CTAAT(A/G)GTAAT | intron-variant | |
| rs1000111556 | -- | 142,624,030(+) | TTCTC(C/T)TGCCT | intron-variant | |
| rs1000156285 | -- | 142,655,486(+) | AGGCA(C/T)TGGGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1046e199 | CNV | deletion | 23128226 |
| esv2421733 | CNV | deletion | 20811451 |
| esv2665244 | CNV | deletion | 23128226 |
| esv2760957 | CNV | loss | 21179565 |
| esv27821 | CNV | loss | 19812545 |
| esv3570474 | CNV | loss | 25503493 |
| esv3606999 | CNV | gain | 21293372 |
| esv3607005 | CNV | gain | 21293372 |
| esv3607006 | CNV | loss | 21293372 |
| esv3607007 | CNV | loss | 21293372 |
| esv3607008 | CNV | loss | 21293372 |
| nsv1023306 | CNV | gain | 25217958 |
| nsv1031126 | CNV | gain | 25217958 |
| nsv1034911 | CNV | gain | 25217958 |
| nsv1123991 | CNV | deletion | 24896259 |
| nsv441966 | CNV | loss | 18776908 |
| nsv514325 | CNV | loss | 21397061 |
| nsv517346 | CNV | loss | 19592680 |
| nsv525272 | CNV | loss | 19592680 |
| nsv823281 | CNV | loss | 20364138 |
| nsv830510 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.69;
14.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGF1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF1 Gene
Disorders for FGF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| overnutrition |
|
|
| blount's disease |
|
|
| sclerosteosis |
|
|
| 8p11 myeloproliferative syndrome |
|
|
| vitreoretinopathy, neovascular inflammatory |
|
Search FGF1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FGF1
No data available for UniProtKB/Swiss-Prot and Genatlas for FGF1 Gene
Publications for FGF1 Gene
- Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. (PMID: 18441324) Mori S. … Takada Y. (J. Biol. Chem. 2008) 3 4 22 64
- The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3- kinase/Akt intracellular signaling pathway. (PMID: 18400376) Di Serio C. … Tarantini F. (Cancer Lett. 2008) 3 4 22 64
- VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PMID: 17204151) Butt C. … Rahman P. (BMC Musculoskelet Disord 2007) 3 22 46 64
- Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 22 46 64
- Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PMID: 11069186) Pellegrini L. … Blundell T.L. (Nature 2000) 3 4 22 64
Products for FGF1 Gene
- R&D Systems Antibodies for FGF1 (FGF acidic)
- R&D Systems Proteins and Enzymes for FGF1 (FGF acidic)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for FGF1 (FGF acidic)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FGF1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF1
- Origene Custom Protein Services for FGF1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGF1
- Browse OriGene Inhibitory RNA Products For FGF1
- OriGene qPCR primer pairs and template standards for FGF1
- OriGene qPCR primer pairs for FGF1
- OriGene CRISPR knockouts for FGF1
- OriGene ORF clones in human for FGF1
- RC207434
- RC207434L1
- RC207434L2
- RG207434
- RC227317
- RC227317L1
- RC227317L2
- RG227317
- RC227790
- RC227790L1
- RC227790L2
- RG227790
- RC227797
- RC227797L1
- RC227797L2
- RG227797
- RC231877
- RG231877
- RC231869
- RG231869
- RC231878
- RG231878
- RC231879
- RG231879
- RC231880
- RG231880
- RC231881
- RG231881
- RC231870
- RG231870
- RC231871
- RG231871
- RC219380
- RC219380L1
- RC219380L2
- RG219380
- RC214005
- RC214005L1
- RC214005L2
- RG214005
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FGF1
- GenScript: Next-day shipping cDNA ORF clone for FGF1 in any vector
- GenScript Purified and Recombinant Proteins for FGF1
- GenScript Custom Purified and Recombinant Proteins Services for FGF1
- GenScript Custom Assay Services for FGF1
- GenScript Custom overexpressing Cell Line Services for FGF1
- GenScript: Design CRISPR guide RNA sequences for FGF1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FGF1
- Cell Signaling Technology (CST) Antibodies for FGF1 (FGF1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for FGF1
- Sino Biological Recombinant Proteins for FGF1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FGF1
- Novus Biologicals proteins and lysates for FGF1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FGF1
- Abcam proteins for FGF1
- Search for Assays for FGF1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for FGF1
- Cloud-Clone Corp. Antibodies for FGF1
- Cloud-Clone Corp. Proteins for FGF1
- Taconic Biosciences Mouse Models for FGF1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for FGF1
- antibodies-online Antibodies for FGF1: See all 196
- antibodies-online Kits for FGF1: See all 86
- antibodies-online Proteins for FGF1: See all 134
- Search antibodies-online for peptides
- GeneTex FGF1 antibody for FGF1
- GeneTex Proteins for FGF1
- ViGene Biosciences adenoviral particle packaged cDNA for FGF1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FGF1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
- Search ViGene Biosciences for FGF1
- Santa Cruz Biotechnology (SCBT) Antibodies for FGF1
- Search Santa Cruz Biotechnology (SCBT) for FGF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FGF1
- Horizon Cell Lines for FGF1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGF1
- VectorBuilder custom plasmid, inducible vectors for FGF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGF1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer