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FGD6 Gene

protein-coding   GIFtS: 51
GCID: GC12M095470

FYVE, RhoGEF And PH Domain Containing 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FYVE, RhoGEF And PH Domain Containing 61 2
Zinc Finger FYVE Domain-Containing Protein 242 3
ZFYVE242 3
FYVE, RhoGEF And PH Domain-Containing Protein 62
KIAA13623

External Ids:    HGNC: 217401   Entrez Gene: 557852   Ensembl: ENSG000001802637   OMIM: 6135205   UniProtKB: Q6ZV733   

Export aliases for FGD6 gene to outside databases

Previous GC identifers: GC12M093976 GC12M092538


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FGD6 Gene:
FGD6 (FYVE, RhoGEF and PH domain containing 6) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHF2.

UniProtKB/Swiss-Prot: FGD6_HUMAN, Q6ZV73
Function: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP
for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGD6 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pbx1a   E2F-2   LCR-F1   E2F   E2F-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGD6 promoter sequence
   Search Chromatin IP Primers for FGD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q23.1

FGD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGD6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M095470:  view genomic region     (about GC identifiers)

Start:
95,470,525 bp from pter      End:
95,611,258 bp from pter
Size:
140,734 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGD6_HUMAN, Q6ZV73 (See protein sequence)
Recommended Name: FYVE, RhoGEF and PH domain-containing protein 6  
Size: 1430 amino acids; 160816 Da
Sequence caution: Sequence=BAA92052.1; Type=Erroneous initiation; Sequence=BAA92600.1; Type=Frameshift;
Positions=1365; Sequence=BAC87464.1; Type=Erroneous initiation; Sequence=CAD98096.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: Q6ZR53 Q7Z2Z7 Q96D44 Q9NUR8 Q9P2I5
Alternative splicing: 2 isoforms:  Q6ZV73-1   Q6ZV73-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FGD6: NX_Q6ZV73

Explore proteomics data for FGD6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060821.3  
    ENSEMBL proteins: 
     ENSP00000344446   ENSP00000448350   ENSP00000408291   ENSP00000450342   ENSP00000450240  
     ENSP00000449005  

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    Cloud-Clone Corp. Proteins for FGD6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 6):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR000306 Znf_FYVE
     IPR011993 PH_like_dom
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q6ZV73

    ProtoNet protein and cluster: Q6ZV73

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB000306 Zn-finger
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: FGD6_HUMAN, Q6ZV73
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 2 PH domains


    Find genes that share domains with FGD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGD6_HUMAN, Q6ZV73
    Function: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP
    for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0031267small GTPase binding ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FGD6           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FGD6:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGD6
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    miRNA
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    miRTarBase miRNAs that target FGD6:
    hsa-mir-98-5p (MIRT027861), hsa-mir-335-5p (MIRT018984)

    Block miRNA regulation of human, mouse, rat FGD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGD6 (see all 85):
    hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-3613-3p hsa-miR-155* hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat FGD6

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGD6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGD6_HUMAN, Q6ZV73: Cytoplasm (Probable). Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    golgi apparatus4
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus ISS--
    GO:0005856cytoskeleton IEA--
    GO:0030027lamellipodium ISS--

    Find genes that share ontologies with FGD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGD6
    Interactions:

        Search GeneGlobe Interaction Network for FGD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FGD6 (Q6ZV733 ENSP000003444464) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=2 STRING: ENSP00000263640
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    AXIN2Q9Y2T13I2D: score=1 
    DVL2O146413I2D: score=1 
    NKD1Q969G93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ISS--
    GO:0008360regulation of cell shape ISS--
    GO:0030036actin cytoskeleton organization ISS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043088regulation of Cdc42 GTPase activity ISS--

    Find genes that share ontologies with FGD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGD6

    1 HMDB Compound for FGD6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGD6 gene: 
    NM_018351.3  

    Unigene Cluster for FGD6:

    FYVE, RhoGEF and PH domain containing 6
    Hs.506381  [show with all ESTs]
    Unigene Representative Sequence: NM_018351
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343958(uc001tdp.4 uc009zsx.3) ENST00000548069 ENST00000451107
    ENST00000546711(uc001tdq.1) ENST00000551521 ENST00000549499 ENST00000550368

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGD6 (see all 85):
    hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-3613-3p hsa-miR-155* hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGD6
      QuantiTect SYBR Green Assays in human, mouse, rat FGD6
      QuantiFast Probe-based Assays in human, mouse, rat FGD6

    Additional mRNA sequence: 

    AB037783.1 AK002045.1 AK026881.1 AK124904.1 AK128492.1 BC013319.1 BC125225.1 BC125226.1 
    BX538322.1 

    6 DOTS entries:

    DT.40280918  DT.433199  DT.91811994  DT.95371363  DT.99958073  DT.95293181 

    Selected AceView cDNA sequences (see all 89):

    CF142584 AU137911 AK124904 BP369194 BM920371 CA503082 BG166270 CB140840 
    AK128492 AW628588 BU183015 AI336120 AA481010 AK002045 BI831154 AI275438 
    BX538322 AI698191 BX353487 BG251080 AI925690 AA760756 BX115949 AW854170 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTTTTAA
    FGD6 Expression
    About this image


    FGD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    FGD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506381
        Custom PCR Arrays for FGD6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGD6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgd61 , 5 FYVE, RhoGEF and PH domain containing 61, 5 80.02(n)1
    76.09(a)1
      10 (48.76 cM)5
    139981  NM_053072.31  NP_444302.41 
     940360015 
    chicken
    (Gallus gallus)
    Aves FGD61 FYVE, RhoGEF and PH domain containing 6 67.56(n)
    64.6(a)
      417908  XM_416149.4  XP_416149.4 
    lizard
    (Anolis carolinensis)
    Reptilia FGD66
    FYVE, RhoGEF and PH domain containing 6
    60(a)
    1 ↔ 1
    5(30896191-30964091)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136592 Xenopus laevis transcribed sequence with weak similarity more 76.09(n)    BX843162.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgd61 FYVE, RhoGEF and PH domain containing 6 55.64(n)
    51.61(a)
      556459  NM_001099980.1  NP_001093450.1 


    ENSEMBL Gene Tree for FGD6 (if available)
    TreeFam Gene Tree for FGD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGD6 gene
    PLEKHF22  FGD32  FGD52  PLEKHF12  FGD22  FGD42  FGD12  
    5 SIMAP similar genes for FGD6 using alignment to 6 protein entries:     FGD6_HUMAN (see all proteins):
    FGD5    FGD4    FGD2    PLEKHF2    PLEKHF1

    Find genes that share paralogs with FGD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGD6 (see all 2995)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105824011,2
    C--92650568(+) aaaaa-/A/AA  
            
    gaaTC
    1 -- int11NA 2
    rs354989111,2
    C--95329047(+) AAAAA-/AAAATA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs710786041,2
    C,F--95342288(-) TTGTT-/TTG/TTGTTTTG
    /TTGTTTTGTTTTG
    TTTTG
    2 -- int1 cds12NA CSA 4
    rs672696281,2
    C--95393680(-) GTGTT-/A/AA  
            
    AAAAA
    1 -- int12NA 4
    rs1431095491,2
    --95470102(+) CCGCTC/TGCCTT 1 -- ds50010--------
    rs1897438781,2
    --95470107(+) CGCCTC/TGGCCT 1 -- ds50010--------
    rs111078831,2
    C,F--95470144(+) GAGCCA/CCCGTG 1 -- ds50013Minor allele frequency- C:0.25NA EA 124
    rs1839119211,2
    --95470174(+) TAAATC/GTGTGA 1 -- ds50010--------
    rs1888559291,2
    --95470176(+) AATGTA/GTGACT 1 -- ds50010--------
    rs1482733801,2
    --95470208(+) ATCTAC/TGATGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGD6 (95470525 - 95611258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FGD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746232CNV Deletion23290073
    esv269352CNV Insertion20981092
    nsv899448CNV Loss21882294
    nsv899449CNV Loss21882294
    nsv526515CNV Loss19592680
    nsv899451CNV Loss21882294
    nsv53566CNV Loss16902084
    nsv899450CNV Gain21882294
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613520    OMIM disorders: --


    Find genes that share disorders with FGD6           About GenesLikeMe

    Genetic Association Database (GAD): FGD6
    Human Genome Epidemiology (HuGE) Navigator: FGD6 (1 document)

    Export disorders for FGD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGD6 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FGD6)
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    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    6. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55785 HGNC: 21740 AceView: FGD6 Ensembl:ENSG00000180263 euGenes: HUgn55785
    ECgene: FGD6 H-InvDB: FGD6

    (According to HUGE)
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    HUGE: KIAA1362

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGD6 gene:
    Search GeneIP for patents involving FGD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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