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Aliases for FGD6 Gene

Aliases for FGD6 Gene

  • FYVE, RhoGEF And PH Domain Containing 6 2 3
  • Zinc Finger FYVE Domain-Containing Protein 24 3 4
  • ZFYVE24 3 4
  • FYVE, RhoGEF And PH Domain-Containing Protein 6 3
  • KIAA1362 4

External Ids for FGD6 Gene

Previous GeneCards Identifiers for FGD6 Gene

  • GC12M093976
  • GC12M095470
  • GC12M092538

Summaries for FGD6 Gene

GeneCards Summary for FGD6 Gene

FGD6 (FYVE, RhoGEF And PH Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is FGD1.

UniProtKB/Swiss-Prot for FGD6 Gene

  • May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGD6 Gene

Genomics for FGD6 Gene

Regulatory Elements for FGD6 Gene

Genomic Location for FGD6 Gene

95,076,749 bp from pter
95,217,482 bp from pter
140,734 bases
Minus strand

Genomic View for FGD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGD6 Gene

Proteins for FGD6 Gene

  • Protein details for FGD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FYVE, RhoGEF and PH domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6ZR53
    • Q7Z2Z7
    • Q96D44
    • Q9NUR8
    • Q9P2I5

    Protein attributes for FGD6 Gene

    1430 amino acids
    Molecular mass:
    160816 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92052.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92600.1; Type=Frameshift; Positions=1365; Evidence={ECO:0000305}; Sequence=BAC87464.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD98096.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for FGD6 Gene


neXtProt entry for FGD6 Gene

Proteomics data for FGD6 Gene at MOPED

Post-translational modifications for FGD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGD6 Gene

No data available for DME Specific Peptides for FGD6 Gene

Domains for FGD6 Gene

Gene Families for FGD6 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ZFYVE :Zinc fingers, FYVE domain containing

Suggested Antigen Peptide Sequences for FGD6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6ZV73
  • Contains 1 DH (DBL-homology) domain.
  • Contains 2 PH domains.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with FGD6: view

Function for FGD6 Gene

Molecular function for FGD6 Gene

UniProtKB/Swiss-Prot Function: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).

Gene Ontology (GO) - Molecular Function for FGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0031267 small GTPase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FGD6: view
genes like me logo Genes that share phenotypes with FGD6: view

miRNA for FGD6 Gene

miRTarBase miRNAs that target FGD6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGD6 Gene

Localization for FGD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGD6 Gene

Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for FGD6 Gene COMPARTMENTS Subcellular localization image for FGD6 gene
Compartment Confidence
cytoskeleton 4
golgi apparatus 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for FGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005856 cytoskeleton IEA --
GO:0030027 lamellipodium ISS --
genes like me logo Genes that share ontologies with FGD6: view

Pathways for FGD6 Gene

SuperPathways for FGD6 Gene

No Data Available

Interacting Proteins for FGD6 Gene

Gene Ontology (GO) - Biological Process for FGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization ISS --
GO:0008360 regulation of cell shape ISS --
GO:0030036 actin cytoskeleton organization ISS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043087 regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with FGD6: view

No data available for Pathways by source for FGD6 Gene

Compounds for FGD6 Gene

(1) HMDB Compounds for FGD6 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with FGD6: view

Transcripts for FGD6 Gene

Unigene Clusters for FGD6 Gene

FYVE, RhoGEF and PH domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGD6 Gene

No ASD Table

Relevant External Links for FGD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGD6 Gene

mRNA expression in normal human tissues for FGD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FGD6 Gene

SOURCE GeneReport for Unigene cluster for FGD6 Gene Hs.506381

genes like me logo Genes that share expressions with FGD6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FGD6 Gene

Orthologs for FGD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGD6 35
  • 99.23 (n)
  • 98.6 (a)
FGD6 36
  • 98 (a)
(Bos Taurus)
Mammalia FGD6 35
  • 87.64 (n)
  • 83.9 (a)
FGD6 36
  • 83 (a)
(Canis familiaris)
Mammalia FGD6 35
  • 89.18 (n)
  • 87.23 (a)
FGD6 36
  • 87 (a)
(Mus musculus)
Mammalia Fgd6 35
  • 80.02 (n)
  • 76.09 (a)
Fgd6 16
Fgd6 36
  • 76 (a)
(Monodelphis domestica)
Mammalia FGD6 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia FGD6 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Fgd6 35
  • 79.77 (n)
  • 76.18 (a)
(Gallus gallus)
Aves FGD6 35
  • 67.56 (n)
  • 64.6 (a)
FGD6 36
  • 62 (a)
(Anolis carolinensis)
Reptilia FGD6 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13659 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fgd6 35
  • 75.54 (n)
  • 81.91 (a)
Str.19905 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7916 35
(Danio rerio)
Actinopterygii fgd6 35
  • 55.64 (n)
  • 51.61 (a)
fgd6 36
  • 45 (a)
Species with no ortholog for FGD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGD6 Gene

Gene Tree for FGD6 (if available)
Gene Tree for FGD6 (if available)

Paralogs for FGD6 Gene

Paralogs for FGD6 Gene

Selected SIMAP similar genes for FGD6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FGD6: view

Variants for FGD6 Gene

Sequence variations from dbSNP and Humsavar for FGD6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs766404 -- 95,209,004(+) TTCTC(A/G)TACTC reference, synonymous-codon
rs882583 -- 95,083,652(-) AATGT(C/T)ACACA intron-variant
rs1865151 -- 95,083,875(+) TGTTC(A/G)AAAGA intron-variant
rs1979586 -- 95,210,697(+) GTGCA(A/G)AAATA reference, missense
rs2043367 -- 95,083,498(+) CAATT(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGD6 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv899448 CNV Loss 21882294
nsv899449 CNV Loss 21882294
nsv899450 CNV Gain 21882294
nsv526515 CNV Loss 19592680
nsv899451 CNV Loss 21882294
nsv53566 CNV Loss 16902084
esv2746232 CNV Deletion 23290073
esv269352 CNV Insertion 20981092

Relevant External Links for FGD6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGD6 Gene

Disorders for FGD6 Gene

Relevant External Links for FGD6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FGD6: view

No data available for UniProtKB/Swiss-Prot for FGD6 Gene

Publications for FGD6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FGD6 Gene

Sources for FGD6 Gene

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