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Aliases for FGD5 Gene

Aliases for FGD5 Gene

  • FYVE, RhoGEF And PH Domain Containing 5 2 3 5
  • Zinc Finger FYVE Domain-Containing Protein 23 3 4
  • ZFYVE23 3 4

External Ids for FGD5 Gene

Previous GeneCards Identifiers for FGD5 Gene

  • GC03P014836
  • GC03P014835
  • GC03P014826

Summaries for FGD5 Gene

GeneCards Summary for FGD5 Gene

FGD5 (FYVE, RhoGEF And PH Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and small GTPase binding. An important paralog of this gene is FGD1.

UniProtKB/Swiss-Prot for FGD5 Gene

  • Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGD5 Gene

Genomics for FGD5 Gene

Regulatory Elements for FGD5 Gene

Enhancers for FGD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGD5 Gene

Chromosome:
3
Start:
14,818,962 bp from pter
End:
14,934,565 bp from pter
Size:
115,604 bases
Orientation:
Plus strand

Genomic View for FGD5 Gene

Genes around FGD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGD5 Gene

Proteins for FGD5 Gene

  • Protein details for FGD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNL6-FGD5_HUMAN
    Recommended name:
    FYVE, RhoGEF and PH domain-containing protein 5
    Protein Accession:
    Q6ZNL6
    Secondary Accessions:
    • B3KVQ3
    • Q6MZY1
    • Q7Z303
    • Q8IYP3
    • Q8N861
    • Q8N8G4

    Protein attributes for FGD5 Gene

    Size:
    1462 amino acids
    Molecular mass:
    159891 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04878.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85128.1; Type=Frameshift; Positions=79; Evidence={ECO:0000305}; Sequence=CAD98090.1; Type=Erroneous termination; Positions=1279; Note=Translated as Lys.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGD5 Gene

    Alternative splice isoforms for FGD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGD5 Gene

Proteomics data for FGD5 Gene at MOPED

Post-translational modifications for FGD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGD5 Gene

No data available for DME Specific Peptides for FGD5 Gene

Domains & Families for FGD5 Gene

Suggested Antigen Peptide Sequences for FGD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNL6

UniProtKB/Swiss-Prot:

FGD5_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 2 PH domains.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with FGD5: view

Function for FGD5 Gene

Molecular function for FGD5 Gene

UniProtKB/Swiss-Prot Function:
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

Gene Ontology (GO) - Molecular Function for FGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
GO:0031267 small GTPase binding ISS --
genes like me logo Genes that share ontologies with FGD5: view
genes like me logo Genes that share phenotypes with FGD5: view

Animal Models for FGD5 Gene

MGI Knock Outs for FGD5:

Animal Model Products

miRNA for FGD5 Gene

miRTarBase miRNAs that target FGD5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGD5 Gene

Localization for FGD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGD5 Gene

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGD5 Gene COMPARTMENTS Subcellular localization image for FGD5 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 3
endoplasmic reticulum 3
endosome 3
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FGD5: view

Pathways & Interactions for FGD5 Gene

SuperPathways for FGD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization ISS --
genes like me logo Genes that share ontologies with FGD5: view

No data available for Pathways by source and SIGNOR curated interactions for FGD5 Gene

Drugs & Compounds for FGD5 Gene

(1) Drugs for FGD5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with FGD5: view

Transcripts for FGD5 Gene

Unigene Clusters for FGD5 Gene

FYVE, RhoGEF and PH domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - -
SP2: -
SP3:
SP4: - - - -

Relevant External Links for FGD5 Gene

GeneLoc Exon Structure for
FGD5
ECgene alternative splicing isoforms for
FGD5

Expression for FGD5 Gene

mRNA expression in normal human tissues for FGD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGD5 Gene

This gene is overexpressed in Bone (41.1), Placenta (12.4), and Spleen (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGD5 Gene



SOURCE GeneReport for Unigene cluster for FGD5 Gene Hs.412406

mRNA Expression by UniProt/SwissProt for FGD5 Gene

Q6ZNL6-FGD5_HUMAN
Tissue specificity: Expressed in endothelial cells (at protein level).
genes like me logo Genes that share expression patterns with FGD5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FGD5 Gene

Orthologs for FGD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGD5 35
  • 79.36 (n)
  • 77.06 (a)
FGD5 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGD5 35
  • 83.52 (n)
  • 81.39 (a)
FGD5 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgd5 35
  • 77.97 (n)
  • 76.4 (a)
Fgd5 16
Fgd5 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGD5 35
  • 99.36 (n)
  • 99.25 (a)
FGD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgd5 35
  • 77.25 (n)
  • 74.17 (a)
oppossum
(Monodelphis domestica)
Mammalia FGD5 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGD5 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGD5 35
  • 68.03 (n)
  • 67.62 (a)
FGD5 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGD5 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgd5 35
  • 63.92 (n)
  • 62.09 (a)
zebrafish
(Danio rerio)
Actinopterygii fgd5a 36
  • 35 (a)
OneToMany
fgd5b 36
  • 53 (a)
OneToMany
Species with no ortholog for FGD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGD5 Gene

ENSEMBL:
Gene Tree for FGD5 (if available)
TreeFam:
Gene Tree for FGD5 (if available)

Paralogs for FGD5 Gene

Paralogs for FGD5 Gene

(2) SIMAP similar genes for FGD5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FGD5 Gene

genes like me logo Genes that share paralogs with FGD5: view

Variants for FGD5 Gene

Sequence variations from dbSNP and Humsavar for FGD5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7636593 - 14,820,278(+) AGGGT(A/G)GAGCG reference, missense
rs17038795 - 14,821,553(+) TCAAC(A/G)CCTTT reference, missense
rs2307092 - 14,897,581(-) CAGCT(C/T)CTCCC reference, missense
rs159206 -- 14,878,782(-) CGCCA(C/T)TGCAC intron-variant
rs718489 -- 14,858,605(-) ATTAC(A/G)AGCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGD5 Gene

Variant ID Type Subtype PubMed ID
esv2724945 CNV Deletion 23290073
nsv876579 CNV Gain 21882294
esv2724960 CNV Deletion 23290073
nsv519602 CNV Loss 19592680
nsv460452 CNV Loss 19166990
dgv1436e1 CNV Complex 17122850
nsv876580 CNV Gain 21882294
nsv834620 CNV Gain 17160897
essv17407 CNV CNV 17122850
nsv10252 CNV Gain 18304495

Variation tolerance for FGD5 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FGD5 Gene

Disorders for FGD5 Gene

Relevant External Links for FGD5

Genetic Association Database (GAD)
FGD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGD5

No disorders were found for FGD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGD5 Gene

Publications for FGD5 Gene

  1. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. (PMID: 22328776) Kurogane Y. … Rikitake Y. (Arterioscler. Thromb. Vasc. Biol. 2012) 3 4 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  3. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. (PMID: 22661514) Cheng C. … Duckers H.J. (Circulation 2012) 3
  4. Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells. (PMID: 22922960) Nakhaei-Nejad M. … Murray A.G. (Arterioscler. Thromb. Vasc. Biol. 2012) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for FGD5 Gene

Sources for FGD5 Gene

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