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FGD5 Gene

protein-coding   GIFtS: 50
GCID: GC03P014860

FYVE, RhoGEF And PH Domain Containing 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FYVE, RhoGEF And PH Domain Containing 51 2
Zinc Finger FYVE Domain-Containing Protein 232 3
ZFYVE232 3
FYVE, RhoGEF And PH Domain-Containing Protein 52

External Ids:    HGNC: 191171   Entrez Gene: 1522732   Ensembl: ENSG000001547837   OMIM: 6147885   UniProtKB: Q6ZNL63   

Export aliases for FGD5 gene to outside databases

Previous GC identifers: GC03P014836 GC03P014835 GC03P014826


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FGD5 Gene:
FGD5 (FYVE, RhoGEF and PH domain containing 5) is a protein-coding gene. Diseases associated with FGD5 include aarskog-scott syndrome, and scott syndrome. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHF2.

UniProtKB/Swiss-Prot: FGD5_HUMAN, Q6ZNL6
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for
free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular
endothelial cells, including network formation, directional movement and proliferation. May play a role in
regulating the actin cytoskeleton and cell shape




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGD5 gene promoter:
         AREB6   Tal-1   Pax-2   Pax-2a   ITF-2   Tal-1beta   c-Ets-1   E47   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGD5 promoter sequence
   Search Chromatin IP Primers for FGD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

FGD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGD5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P014860:  view genomic region     (about GC identifiers)

Start:
14,860,469 bp from pter      End:
14,976,072 bp from pter
Size:
115,604 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FGD5_HUMAN, Q6ZNL6 (See protein sequence)
Recommended Name: FYVE, RhoGEF and PH domain-containing protein 5  
Size: 1462 amino acids; 159891 Da
Sequence caution: Sequence=BAC04878.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC04989.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC85128.1;
Type=Frameshift; Positions=79; Sequence=CAD98090.1; Type=Erroneous termination; Positions=1279; Note=Translated
as Lys;
1 PDB 3D structure from and Proteopedia for FGD5:
3MPX (3D)    
Secondary accessions: B3KVQ3 Q6MZY1 Q7Z303 Q8IYP3 Q8N861 Q8N8G4
Alternative splicing: 2 isoforms:  Q6ZNL6-1   Q6ZNL6-2   

Explore the universe of human proteins at neXtProt for FGD5: NX_Q6ZNL6

Explore proteomics data for FGD5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689749.3  
    ENSEMBL proteins: 
     ENSP00000285046   ENSP00000394827   ENSP00000445949  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 6):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR000306 Znf_FYVE
     IPR011993 PH_like_dom
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q6ZNL6

    ProtoNet protein and cluster: Q6ZNL6

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB000306 Zn-finger
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: FGD5_HUMAN, Q6ZNL6
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 2 PH domains


    FGD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGD5_HUMAN, Q6ZNL6
    Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for
    free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular
    endothelial cells, including network formation, directional movement and proliferation. May play a role in
    regulating the actin cytoskeleton and cell shape

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0031267small GTPase binding ISS--
    GO:0046872metal ion binding IEA--
         
    FGD5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGD5:
     Decreased cell number 

    Animal Models:
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    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-331-3p hsa-miR-302e hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFGD5 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat FGD5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGD5_HUMAN, Q6ZNL6: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi
    apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs,
    detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    endosome5
    golgi apparatus5
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005737cytoplasm ISS--
    GO:0005769early endosome IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus ISS--

    FGD5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGD5
    Interactions:

        Search GeneGlobe Interaction Network for FGD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FGD5 (Q6ZNL61, 2 ENSP000002850464) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUV39H1O434631EBI-7962481,EBI-349968
    RRAGCENSP000003620924STRING: ENSP00000362092
    RRAGDENSP000003584234STRING: ENSP00000358423
    IL4ENSP000002314494STRING: ENSP00000231449
    RRAGAENSP000003698994STRING: ENSP00000369899
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ISS--
    GO:0008360regulation of cell shape ISS--
    GO:0030036actin cytoskeleton organization ISS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043088regulation of Cdc42 GTPase activity ISS--

    FGD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGD5

    1 HMDB Compound for FGD5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGD5 gene: 
    NM_152536.3  

    Unigene Cluster for FGD5:

    FYVE, RhoGEF and PH domain containing 5
    Hs.412406  [show with all ESTs]
    Unigene Representative Sequence: NM_152536
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285046(uc003bzc.3 uc011avk.2 uc003bzd.3) ENST00000457774
    ENST00000468662 ENST00000476851 ENST00000487605 ENST00000543601
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGD5 (see all 30):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-331-3p hsa-miR-302e hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFGD5 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FGD5

    Additional mRNA sequence: 

    AK057128.1 AK096856.1 AK097276.1 AK123054.1 AK131078.1 BC035364.1 BC040614.1 BC132814.1 
    BC132816.1 BC144300.1 BX538312.1 BX640820.1 

    6 DOTS entries:

    DT.315322  DT.120877734  DT.97800420  DT.315323  DT.91665258  DT.315321 

    Selected AceView cDNA sequences (see all 102):

    AI493859 CA406813 Z39447 BX282457 AA694355 W93831 AI384120 CD369560 
    AK131078 BM473663 W67715 BX538312 BU101917 AK096856 AW269340 NM_152536 
    W68174 AW136166 F02368 BC040614 AA402358 BQ329962 CD672756 CA440102 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FGD5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                -     -                                                                                                               
    SP2:                                      -                                                                                                               
    SP3:                                                                                                                                                      
    SP4:                    -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for FGD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGGGTGG
    FGD5 Expression
    About this image


    FGD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Umbilical Cord (Extraembryonic Tissues)
    FGD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412406

    UniProtKB/Swiss-Prot: FGD5_HUMAN, Q6ZNL6
    Tissue specificity: Expressed in endothelial cells (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGD5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgd51 , 5 FYVE, RhoGEF and PH domain containing 51, 5 77.97(n)1
    76.4(a)1
      6 (41.00 cM)5
    2322371  NM_172731.21  NP_766319.21 
     919788785 
    chicken
    (Gallus gallus)
    Aves FGD51 FYVE, RhoGEF and PH domain containing 5 68.03(n)
    67.62(a)
      416130  XM_414463.4  XP_414463.4 
    lizard
    (Anolis carolinensis)
    Reptilia FGD56
    FYVE, RhoGEF and PH domain containing 5
    70(a)
    1 ↔ 1
    2(170722046-170774635)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgd51 FYVE, RhoGEF and PH domain containing 5 63.92(n)
    62.09(a)
      100496480  XM_002938237.2  XP_002938283.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fgd5b6
    fgd5a6
    FYVE, RhoGEF and PH domain containing 5a
    53(a)
    35(a)
    1 ↔ many
    1 ↔ many
    6(40413194-40430663) ENSDARG00000089622
    11(18817201-18888914) ENSDARG00000088801


    ENSEMBL Gene Tree for FGD5 (if available)
    TreeFam Gene Tree for FGD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGD5 gene
    PLEKHF22  FGD32  PLEKHF12  FGD22  FGD62  FGD42  FGD12  
    2 SIMAP similar genes for FGD5 using alignment to 5 protein entries:     FGD5_HUMAN (see all proteins):
    FGD6    FGD4

    FGD5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FGD5
    PGOHUM00000237949


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGD5 (see all 2753)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs738141821,2
    C,F--14858593(+) CACTTA/CGTATG 1 -- us2k14Minor allele frequency- C:0.27WA CSA 123
    rs1887483911,2
    --14858749(+) CCAGGC/TGGGAG 1 -- us2k10--------
    rs2020048711,2
    C--14858780(+) TATTG-/CCAACC 1 -- us2k10--------
    rs1180695291,2
    C,F--14858990(+) GAGCCA/GCTGCA 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1465648791,2
    --14859073(+) CTCACA/GTTCCA 1 -- us2k10--------
    rs1410109471,2
    --14859078(+) ATTCCA/TGGGAC 1 -- us2k10--------
    rs76438291,2
    C,F,A,H--14859128(+) GACAAC/AACTGG 1 -- us2k194Minor allele frequency- A:0.04NS EA NA PA EU CA WA CSA 5212
    rs1447452361,2
    --14859165(+) TTTGCC/TGGCAG 1 -- us2k10--------
    rs1925837861,2
    --14859300(+) GAAACA/GTGGGA 1 -- us2k10--------
    rs76240401,2
    C,F,H--14859325(+) GTGGCA/GGGGAT 1 -- us2k19Minor allele frequency- G:0.13NS EA WA CSA 521

    HapMap Linkage Disequilibrium report for FGD5 (14860469 - 14976072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FGD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724960CNV Deletion23290073
    esv2724945CNV Deletion23290073
    nsv460452CNV Loss19166990
    nsv519602CNV Loss19592680
    nsv10252CNV Gain18304495
    nsv834620CNV Gain17160897
    nsv876579CNV Gain21882294
    nsv876580CNV Gain21882294
    essv17407CNV CNV17122850
    dgv1436e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 614788    OMIM disorders: --

    5 diseases for FGD5:    
    About MalaCards
    aarskog-scott syndrome    scott syndrome    gastroduodenitis    endotheliitis
    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for FGD5:
    Gastroduodenitis     Aarskog-Scott syndrome

    FGD5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FGD5

    Export disorders for FGD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGD5 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with FGD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. (PubMed id 22328776)1, 2 Kurogane Y.... Rikitake Y. (Arterioscler. Thromb. Vasc. Biol. 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1, 2 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    6. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. (PubMed id 22661514)1 Cheng C....Duckers H.J. (Circulation 2012)
    7. Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells. (PubMed id 22922960)1 Nakhaei-Nejad M....Murray A.G. (Arterioscler. Thromb. Vasc. Biol. 2012)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 152273 HGNC: 19117 AceView: FGD5 Ensembl:ENSG00000154783 euGenes: HUgn152273
    ECgene: FGD5 H-InvDB: FGD5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FGD5 gene:
    Search GeneIP for patents involving FGD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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