Aliases for FGD5 Gene
External Ids for FGD5 Gene
Previous GeneCards Identifiers for FGD5 Gene
GeneCards Summary for FGD5 Gene
FGD5 (FYVE, RhoGEF And PH Domain Containing 5) is a Protein Coding gene. Diseases associated with FGD5 include gastroduodenitis and aarskog-scott syndrome. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is FGD1.
UniProtKB/Swiss-Prot for FGD5 Gene
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.