Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FGD5 Gene

Aliases for FGD5 Gene

  • FYVE, RhoGEF And PH Domain Containing 5 2 3
  • Zinc Finger FYVE Domain-Containing Protein 23 3 4
  • ZFYVE23 3 4
  • FYVE, RhoGEF And PH Domain-Containing Protein 5 3

External Ids for FGD5 Gene

Previous GeneCards Identifiers for FGD5 Gene

  • GC03P014836
  • GC03P014835
  • GC03P014826

Summaries for FGD5 Gene

GeneCards Summary for FGD5 Gene

FGD5 (FYVE, RhoGEF And PH Domain Containing 5) is a Protein Coding gene. Diseases associated with FGD5 include gastroduodenitis and aarskog-scott syndrome. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is FGD1.

UniProtKB/Swiss-Prot for FGD5 Gene

  • Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGD5 Gene

Genomics for FGD5 Gene

Regulatory Elements for FGD5 Gene

Genomic Location for FGD5 Gene

Start:
14,810,740 bp from pter
End:
14,934,565 bp from pter
Size:
123,826 bases
Orientation:
Plus strand

Genomic View for FGD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGD5 Gene

Proteins for FGD5 Gene

  • Protein details for FGD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNL6-FGD5_HUMAN
    Recommended name:
    FYVE, RhoGEF and PH domain-containing protein 5
    Protein Accession:
    Q6ZNL6
    Secondary Accessions:
    • B3KVQ3
    • Q6MZY1
    • Q7Z303
    • Q8IYP3
    • Q8N861
    • Q8N8G4

    Protein attributes for FGD5 Gene

    Size:
    1462 amino acids
    Molecular mass:
    159891 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04878.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85128.1; Type=Frameshift; Positions=79; Evidence={ECO:0000305}; Sequence=CAD98090.1; Type=Erroneous termination; Positions=1279; Note=Translated as Lys.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGD5 Gene

    Alternative splice isoforms for FGD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGD5 Gene

Proteomics data for FGD5 Gene at MOPED

Post-translational modifications for FGD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGD5 Gene

Domains for FGD5 Gene

Gene Families for FGD5 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ZFYVE :Zinc fingers, FYVE domain containing

Suggested Antigen Peptide Sequences for FGD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNL6

UniProtKB/Swiss-Prot:

FGD5_HUMAN :
  • Q6ZNL6
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 2 PH domains.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with FGD5: view

Function for FGD5 Gene

Molecular function for FGD5 Gene

UniProtKB/Swiss-Prot Function:
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

Gene Ontology (GO) - Molecular Function for FGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 23455924
GO:0031267 small GTPase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FGD5: view

Phenotypes for FGD5 Gene

GenomeRNAi human phenotypes for FGD5:
genes like me logo Genes that share phenotypes with FGD5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FGD5 Gene

Localization for FGD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGD5 Gene

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGD5 Gene COMPARTMENTS Subcellular localization image for FGD5 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for FGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005737 cytoplasm ISS --
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with FGD5: view

Pathways for FGD5 Gene

SuperPathways for FGD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization ISS --
GO:0008360 regulation of cell shape ISS --
GO:0030036 actin cytoskeleton organization ISS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043087 regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with FGD5: view

No data available for Pathways by source for FGD5 Gene

Compounds for FGD5 Gene

(1) HMDB Compounds for FGD5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with FGD5: view

Transcripts for FGD5 Gene

Unigene Clusters for FGD5 Gene

FYVE, RhoGEF and PH domain containing 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGD5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - -
SP2: -
SP3:
SP4: - - - -

Relevant External Links for FGD5 Gene

GeneLoc Exon Structure for
FGD5
ECgene alternative splicing isoforms for
FGD5

Expression for FGD5 Gene

mRNA expression in normal human tissues for FGD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FGD5 Gene

This gene is overexpressed in Bone (41.1), Placenta (12.4), and Spleen (7.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGD5 Gene

SOURCE GeneReport for Unigene cluster for FGD5 Gene Hs.412406

mRNA Expression by UniProt/SwissProt for FGD5 Gene

Q6ZNL6-FGD5_HUMAN
Tissue specificity: Expressed in endothelial cells (at protein level).
genes like me logo Genes that share expressions with FGD5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for FGD5 Gene

Orthologs for FGD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGD5 35
  • 79.36 (n)
  • 77.06 (a)
FGD5 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGD5 35
  • 83.52 (n)
  • 81.39 (a)
FGD5 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgd5 35
  • 77.97 (n)
  • 76.4 (a)
Fgd5 16
Fgd5 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGD5 35
  • 99.36 (n)
  • 99.25 (a)
FGD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgd5 35
  • 77.25 (n)
  • 74.17 (a)
oppossum
(Monodelphis domestica)
Mammalia FGD5 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGD5 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGD5 35
  • 68.03 (n)
  • 67.62 (a)
FGD5 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGD5 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgd5 35
  • 63.92 (n)
  • 62.09 (a)
zebrafish
(Danio rerio)
Actinopterygii fgd5a 36
  • 35 (a)
OneToMany
fgd5b 36
  • 53 (a)
OneToMany
Species with no ortholog for FGD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGD5 Gene

ENSEMBL:
Gene Tree for FGD5 (if available)
TreeFam:
Gene Tree for FGD5 (if available)

Paralogs for FGD5 Gene

Paralogs for FGD5 Gene

Selected SIMAP similar genes for FGD5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FGD5 Gene

genes like me logo Genes that share paralogs with FGD5: view

Variants for FGD5 Gene

Sequence variations from dbSNP and Humsavar for FGD5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs159206 -- 14,878,782(-) CGCCA(C/T)TGCAC intron-variant
rs172414 -- 14,904,610(-) aatga(C/T)tgatt intron-variant
rs172429 -- 14,864,006(-) ACAAA(A/C)TTCCT intron-variant
rs182398 -- 14,921,441(-) CATCC(A/G)ACAGG intron-variant
rs182403 -- 14,861,884(-) TGATC(A/G)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGD5 Gene

Variant ID Type Subtype PubMed ID
esv2724945 CNV Deletion 23290073
nsv876579 CNV Gain 21882294
esv2724960 CNV Deletion 23290073
nsv519602 CNV Loss 19592680
nsv460452 CNV Loss 19166990
dgv1436e1 CNV Complex 17122850
nsv876580 CNV Gain 21882294
nsv834620 CNV Gain 17160897
essv17407 CNV CNV 17122850
nsv10252 CNV Gain 18304495

Relevant External Links for FGD5 Gene

HapMap Linkage Disequilibrium report
FGD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGD5 Gene

Disorders for FGD5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FGD5 Gene in MalaCards »

(3) Diseases for FGD5 Gene including...

(2) University of Copenhagen DISEASES for FGD5 Gene

Relevant External Links for FGD5

Genetic Association Database (GAD)
FGD5
genes like me logo Genes that share disorders with FGD5: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FGD5 Gene

Publications for FGD5 Gene

  1. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. (PMID: 22328776) Kurogane Y. … Rikitake Y. (Arterioscler. Thromb. Vasc. Biol. 2012) 3 4
  5. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. (PMID: 22661514) Cheng C. … Duckers H.J. (Circulation 2012) 3

Products for FGD5 Gene

Sources for FGD5 Gene

Back to Top

Content