Aliases for FGD4 Gene
Aliases for FGD4 Gene
External Ids for FGD4 Gene
- HGNC: 19125
- Entrez Gene: 121512
- Ensembl: ENSG00000139132
- OMIM: 611104
- UniProtKB: Q96M96
Previous GeneCards Identifiers for FGD4 Gene
- GC12P032546
- GC12P032654
Summaries for FGD4 Gene
-
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
GeneCards Summary for FGD4 Gene
FGD4 (FYVE, RhoGEF And PH Domain Containing 4) is a Protein Coding gene. Diseases associated with FGD4 include Charcot-Marie-Tooth Disease, Type 4H and Neuropathy, Congenital Hypomyelinating. Among its related pathways are p75 NTR receptor-mediated signalling and G-protein signaling_Regulation of CDC42 activity. GO annotations related to this gene include actin binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is FGD1.
UniProtKB/Swiss-Prot for FGD4 Gene
-
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGD4 Gene
Genomics for FGD4 Gene
Regulatory Elements for FGD4 Gene
Enhancers for FGD4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G032451 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 18.3 | +55.3 | 55282 | 5.7 | CTCF JUN MAX CHD7 RAD21 RFX5 GATA3 CTBP1 GATA2 EED | FGD4 RNU6-494P ENSG00000207176 |
| GH12G032435 | 1.4 | Ensembl ENCODE dbSUPER | 20.5 | +39.2 | 39215 | 6.1 | ELF3 FOXA2 ARID4B SIN3A DNMT3B THRB ZSCAN9 RARA RFX5 TCF12 | FGD4 ENSG00000207176 RNU6-494P AMN1 |
| GH12G032422 | 1.2 | Ensembl ENCODE dbSUPER | 21.8 | +23.6 | 23553 | 0.6 | HDAC1 L3MBTL2 MAFG BACH1 MAX OSR2 ZNF316 MAFF NFE2L1 NFE2 | FGD4 ENSG00000207176 RNU6-494P |
| GH12G032444 | 1.4 | Ensembl ENCODE dbSUPER | 17.8 | +46.4 | 46351 | 3.1 | FOXA2 NFIB RARA GATA2 ZNF366 RCOR1 FOS THAP11 CEBPB ZEB2 | FGD4 RNU6-494P ENSG00000207176 |
| GH12G032450 | 1.3 | Ensembl ENCODE dbSUPER | 18.8 | +51.4 | 51432 | 1.4 | EED ETV6 FOS IKZF2 CREM RFX1 MTA2 ZBED1 CBFB BHLHE40 | FGD4 RNU6-494P ENSG00000207176 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGD4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FGD4 Gene
- Chromosome:
- 12
- Start:
- 32,399,529 bp from pter
- End:
- 32,646,050 bp from pter
- Size:
- 246,522 bases
- Orientation:
- Plus strand
Genomic View for FGD4 Gene
Genes around FGD4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by Ensembl
- 12p11.21 by Entrez Gene
- 12p11.21 by HGNC
FGD4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGD4 Gene
Proteins for FGD4 Gene
-
Protein details for FGD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96M96-FGD4_HUMAN
- Recommended name:
- FYVE, RhoGEF and PH domain-containing protein 4
- Protein Accession:
- Q96M96
- Q6ULS2
- Q8TCP6
Protein attributes for FGD4 Gene
- Size:
- 766 amino acids
- Molecular mass:
- 86626 Da
- Quaternary structure:
-
- Homooligomer.
Protein Expression for FGD4 Gene
Post-translational modifications for FGD4 Gene
Other Protein References for FGD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001291409.1
- NP_001291410.1
- NP_001291412.1
- NP_001291413.1
- NP_001317302.1
- NP_001317303.1
- NP_640334.2
- XP_005253361.1
- XP_005253364.1
- XP_005253365.1
- XP_005253366.1
- XP_005253367.1
- XP_011518856.1
- XP_011518857.1
- XP_011518858.1
- XP_011518859.1
- XP_011518860.1
- XP_011518861.1
- XP_016874292.1
- XP_016874293.1
- XP_016874294.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FGD4
- Novus Biologicals Antibodies for FGD4
- Invitrogen Antibodies for FGD4
- antibodies-online Antibodies for FGD4: See all 24
- GeneTex FGD4 antibody for FGD4
Protein Products
-
OriGene Purified Proteins for FGD4
- Search Origene for MassSpec and Protein Over-expression Lysates for FGD4
- Origene Custom Protein Services for FGD4
- antibodies-online Proteins for FGD4: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGD4
Assay Products
No data available for DME Specific Peptides for FGD4 Gene
Domains & Families for FGD4 Gene
Gene Families for FGD4 Gene
Protein Domains for FGD4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGD4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96M96UniProtKB/Swiss-Prot:
FGD4_HUMAN :- The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PH domain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domains with the exception of the actin filament-binding domain (By similarity).
- Domain:
-
- The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PH domain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domains with the exception of the actin filament-binding domain (By similarity).
Function for FGD4 Gene
Molecular function for FGD4 Gene
- UniProtKB/Swiss-Prot Function:
- Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA,TAS | -- |
| GO:0031267 | small GTPase binding | ISS | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FGD4 Gene
- MGI mutant phenotypes for FGD4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FGD4:
Animal Models for FGD4 Gene
- MGI Knock Outs for FGD4:
-
- Fgd4 tm1.1Ics
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FGD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGD4 gene
- Search ViGene Biosciences for FGD4
CRISPR Products
-
OriGene CRISPR knockouts for FGD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGD4
- GenScript: Design CRISPR guide RNA sequences for FGD4
miRNA for FGD4 Gene
- miRTarBase miRNAs that target FGD4
-
- hsa-mir-4487 (MIRT272324)
- hsa-mir-526b-5p (MIRT448830)
- hsa-mir-431-5p (MIRT448831)
- hsa-mir-6716-5p (MIRT448832)
- hsa-mir-558 (MIRT448833)
- hsa-mir-3160-3p (MIRT448834)
- hsa-mir-4646-5p (MIRT448835)
- hsa-mir-204-3p (MIRT448836)
- hsa-mir-1-3p (MIRT448837)
- hsa-mir-206 (MIRT448838)
- hsa-mir-613 (MIRT448839)
- hsa-mir-129-5p (MIRT668359)
- hsa-mir-3152-5p (MIRT668360)
- hsa-mir-4774-3p (MIRT668361)
- hsa-mir-3942-3p (MIRT668362)
- hsa-mir-6836-3p (MIRT668363)
- hsa-mir-5100 (MIRT668364)
- hsa-mir-4797-3p (MIRT668365)
- hsa-mir-545-5p (MIRT668366)
- hsa-mir-10b-3p (MIRT668367)
- hsa-mir-4266 (MIRT703561)
- hsa-mir-499a-5p (MIRT703562)
- hsa-mir-208b-3p (MIRT703563)
- hsa-mir-208a-3p (MIRT703564)
- hsa-mir-302f (MIRT703565)
- hsa-mir-641 (MIRT703566)
- hsa-mir-3617-5p (MIRT703567)
- hsa-mir-335-3p (MIRT709060)
- hsa-mir-5096 (MIRT709061)
- hsa-mir-197-3p (MIRT709062)
- hsa-mir-4742-3p (MIRT709063)
- hsa-mir-339-5p (MIRT709064)
- hsa-mir-490-5p (MIRT709065)
- hsa-mir-7153-3p (MIRT709066)
miRNA Products
- Search ViGene Biosciences for FGD4
Inhibitory RNA Products
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-
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Horizon Cell Lines for FGD4
-
ViGene Biosciences adenoviral particle packaged cDNA for FGD4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGD4 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGD4 Gene
Localization for FGD4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGD4 Gene
- Cytoplasm, cytoskeleton. Cell projection, filopodium. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| golgi apparatus | 4 |
| nucleus | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005794 | Golgi apparatus | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for FGD4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Rho GTPases | ||
| 4 | RET signaling | ||
| 5 | G-protein signaling_Regulation of CDC42 activity | ||
Pathways by source for FGD4 Gene
1 GeneGo (Thomson Reuters) pathway for FGD4 Gene
Interacting Proteins for FGD4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | ISS | -- |
| GO:0008360 | regulation of cell shape | ISS | -- |
| GO:0030032 | lamellipodium assembly | IEA | -- |
| GO:0030035 | microspike assembly | IEA | -- |
| GO:0030036 | actin cytoskeleton organization | ISS | -- |
No data available for SIGNOR curated interactions for FGD4 Gene
Transcripts for FGD4 Gene
mRNA/cDNA for FGD4 Gene
- (21) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (110) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGD4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGD4
- GenScript: Design CRISPR guide RNA sequences for FGD4
miRNA Products
- Search ViGene Biosciences for FGD4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGD4
- Browse OriGene Inhibitory RNA Products For FGD4
-
ViGene Biosciences ready-to-package AAV shRNAs for FGD4 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Expression for FGD4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
This gene is overexpressed in Stomach (15.0), Peripheral blood mononuclear cells (10.3), and Placenta (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGD4 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGD4 Gene:
FGD4SOURCE GeneReport for Unigene cluster for FGD4 Gene:
Hs.117835mRNA Expression by UniProt/SwissProt for FGD4 Gene:
Q96M96-FGD4_HUMAN
Tissue specificity:
Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis.
Evidence on tissue expression from TISSUES for FGD4 Gene
- Liver(4.2)
- Nervous system(3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FGD4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- nervous
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- head
Thorax:
- lung
- rib
- rib cage
Pelvis:
- pelvis
Limb:
- foot
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for FGD4
No data available for mRNA differential expression in normal tissues for FGD4 Gene
Orthologs for FGD4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGD4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGD4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGD4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgd4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgd4 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGD4 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FGD4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGD4 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FGD4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgd4 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgd4a 34 35 |
|
||
| CABZ01078314.1 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | RhoGEF4 35 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | exc-5 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6211 35 |
|
OneToMany |
- Species where no ortholog for FGD4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FGD4 Gene
(6) SIMAP similar genes for FGD4 Gene using alignment to 13 proteins:
Variants for FGD4 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs63749871 | Pathogenic, Charcot-Marie-Tooth disease 4H (CMT4H) [MIM:609311], Charcot-Marie-Tooth disease 4H (CMT4H) [MIM:609311] | 32,602,217(+) | TAAGA(C/G/T)GTATG | nc-transcript-variant, reference, missense, utr-variant-5-prime | |
| rs118203972 | Pathogenic | 32,598,566(+) | TCAAC(C/T)GACTT | nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime | |
| rs118203973 | Pathogenic | 32,625,774(+) | CATGT(G/T)GATAT | reference, stop-gained | |
| rs118203974 | Pathogenic | 32,601,410(+) | AGAAA(C/T)GAATG | intron-variant, nc-transcript-variant, reference, stop-gained, utr-variant-5-prime | |
| rs281865063 | Pathogenic | 32,611,270(+) | AGAAC(A/G)CTACC | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2751096 | CNV | gain | 17911159 |
| esv3382704 | CNV | insertion | 20981092 |
| esv3581449 | CNV | gain | 25503493 |
| esv3629083 | CNV | loss | 21293372 |
| esv3629084 | CNV | loss | 21293372 |
| esv3629085 | CNV | gain | 21293372 |
| nsv1122716 | CNV | deletion | 24896259 |
| nsv473072 | CNV | novel sequence insertion | 20440878 |
| nsv527786 | CNV | gain | 19592680 |
| nsv951347 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.31;
95.33% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGD4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGD4 Gene
Disorders for FGD4 Gene
(8) MalaCards diseases for FGD4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| charcot-marie-tooth disease, type 4h |
|
|
| neuropathy, congenital hypomyelinating |
|
|
| tooth disease |
|
|
| sensory peripheral neuropathy |
|
|
| charcot-marie-tooth disease |
|
|
Search FGD4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FGD4_HUMAN- Charcot-Marie-Tooth disease 4H (CMT4H) [MIM:609311]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. {ECO:0000269 PubMed:17564959, ECO:0000269 PubMed:17564972}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for FGD4
No data available for Genatlas for FGD4 Gene
Publications for FGD4 Gene
- Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. (PMID: 17564972) Stendel C. … Senderek J. (Am. J. Hum. Genet. 2007) 3 4 22 64
- Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. (PMID: 15133042) Chen X.M. … LaRusso N.F. (J. Biol. Chem. 2004) 3 4 22 64
- Identification of splicing variants of Frabin with partly different functions and tissue distribution. (PMID: 11527409) Ikeda W. … Takai Y. (Biochem. Biophys. Res. Commun. 2001) 2 3 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- A novel Frabin (FGD4) nonsense mutation p.R275X associated with phenotypic variability in CMT4H. (PMID: 19221294) Houlden H. … Reilly M.M. (Neurology 2009) 3 22 64
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FGD4
- Novus Biologicals proteins and lysates for FGD4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FGD4: See all 24
- Search antibodies-online for kits
- antibodies-online Proteins for FGD4: See all 4
- Search antibodies-online for peptides
- GeneTex FGD4 antibody for FGD4
- Search GeneTex for Proteins for FGD4
- ViGene Biosciences adenoviral particle packaged cDNA for FGD4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FGD4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FGD4 gene
- Search ViGene Biosciences for FGD4
- Horizon Cell Lines for FGD4
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGD4
- VectorBuilder custom plasmid, inducible vectors for FGD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGD4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGD4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer