FGD4 Gene
protein-coding GIFtS: 61
GCID: GC12P032546
|
|
FYVE, RhoGEF and PH domain containing 4(Previous names: FGD1 family, member 4 )
| |
Aliases
for FGD4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FYVE, RhoGEF And PH Domain Containing 41 2 | | FGD1-Related F-Actin-Binding Protein2 3 | | FRABP1 2 3 | | Frabin1 | | ZFYVE61 2 3 | | Actin-Filament Binding Protein Frabin2 | | CMT4H1 2 5 | | FYVE, RhoGEF And PH Domain-Containing Protein 42 | | FGD1 Family, Member 41 2 | | Actin Filament-Binding Protein Frabin3 | | Zinc Finger FYVE Domain-Containing Protein 62 3 | | FRABIN5 |
Export aliases for FGD4 gene to outside databasesPrevious GC identifers: GC12P032654 GC12P032407 |
Summaries
for FGD4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGD4:
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This proteincontains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrinhomology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-bindingdomain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activationof CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, anintracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Toothdisease type 4H (CMT4H), a disorder of the peripheral nervous system. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: FGD4_HUMAN, Q96M96Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for freeGTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)
Gene Wiki entry for FGD4
|
Genomic Views
for FGD4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGD4 gene promoter:
Sox5 AML1a FOXF2 p300 Tal-1beta E47 AREB6 MEF-2A Sox9 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGD4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGD4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11.21 Ensembl cytogenetic band: 12p11.21 HGNC cytogenetic band: 12p11.1FGD4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P032546: view genomic region
(about GC identifiers)
Start:
|
32,552,463 bp from pter |
End:
|
32,798,984 bp from pter |
Size:
|
246,522 bases |
Orientation:
|
plus strand |
|
Proteins
for FGD4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FGD4_HUMAN, Q96M96 (See
protein sequence)Recommended Name: FYVE, RhoGEF and PH domain-containing protein 4 Size: 766 amino acids; 86626 Da
Subunit: Homooligomer (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, filopodium (By similarity).Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (Bysimilarity)
Secondary accessions: Q6ULS2 Q8TCP6Alternative splicing: 3 isoforms: Q96M96-1 Q96M96-2 Q96M96-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FGD4: NX_Q96M96
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M96
FGD4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_640334.2
ENSEMBL proteins: ENSP00000449273 ENSP00000431323 ENSP00000434356 ENSP00000437109 ENSP00000449614 ENSP00000394487 ENSP00000379089 ENSP00000446695 ENSP00000462623 ENSP00000433666 ENSP00000434062 ENSP00000266482 ENSP00000370413 Reactome Protein details: Q96M96
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
FGD4 for ontologies About GeneDecksing
FGD4 Antibody Products:
Assay Products for FGD4: |
Protein
Domains /
Families
for FGD4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGD4 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q96M96ProtoNet protein and cluster: Q96M96 3 Blocks protein families: IPB000219 DH domain IPB000306 Zn-finger IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: FGD4_HUMAN, Q96M96Domain: The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PHdomain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domainswith the exception of the actin filament-binding domain (By similarity)Similarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 2 PH domains |
Function
for FGD4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FGD4_HUMAN, Q96M96Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for freeGTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGD4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGD4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FGD4 (NM_139241) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FGD4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGD4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGD4 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- | | GO:0005085 | guanyl-nucleotide exchange factor activity |
ISS | -- | | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- | | GO:0005543 | phospholipid binding |
IEA | -- | | GO:0031267 | small GTPase binding |
ISS | -- |
FGD4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FGD4:
Animal Models:
Mouse knock-out Fgd4tm1.1Ics for FGD4
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fgd4):
FGD4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FGD4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | | | 3 | G-protein signaling Regulation of RAC1 activity | | | 4 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for FGD4
1  GeneGo (Thomson Reuters) Pathway for FGD4
5/10 
Reactome Pathways for FGD4 (see all 10)
FGD4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGD4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for FGD4 (Q96M963 ENSP000003944874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
TAS | -- | | GO:0007010 | cytoskeleton organization |
ISS | -- | | GO:0007257 | activation of JUN kinase activity |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0008360 | regulation of cell shape |
ISS | -- |
FGD4 for ontologies About GeneDecksing
|
Drugs & Compounds
for FGD4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FGD4 for compounds About GeneDecksing
 Browse Tocris compounds for FGD4
1 HMDB Compound for FGD4 About this table
2 Novoseek chemical compound relationships for FGD4 gene About this table
Search CenterWatch for drugs/clinical trials and news about FGD4
|
Transcripts
for FGD4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FGD4 gene: NM_139241.2 Unigene Cluster for FGD4: FYVE, RhoGEF and PH domain containing 4 Hs.117835 [show with all ESTs]Unigene Representative Sequence: NM_13924118 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534526 ENST00000550091 ENST00000531134 ENST00000472289(uc001rkx.4)
ENST00000494275 ENST00000497153 ENST00000493087 ENST00000551984 ENST00000427716(uc001rlc.3 uc001rkz.3 uc001rla.3 uc010ske.2 uc001rlb.1)
ENST00000473513 ENST00000395740(uc001rky.3) ENST00000479023 ENST00000546442
ENST00000583694 ENST00000525053 ENST00000494977 ENST00000266482 ENST00000381025
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGD4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGD4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FGD4 (NM_139241) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FGD4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGD4 |
Additional cDNA sequence: AK057294.1 AK091689.1 AK124654.1 AK297025.1 AK303334.1 AL832064.1 BC039708.1 BC045552.1 BC063403.1 BC096746.1 11 DOTS entries: DT.211504 DT.101980107 DT.101969988 DT.86858699 DT.101980108 DT.99982574 DT.100754483 DT.121211720 DT.121211654 DT.434753 DT.92417795 24/110 AceView cDNA sequences (see all 110): AW005825 AI251842 BC039708 BC063403 BF510975 AA412504 AI824076 AI933640 CB124491 BU742508 AL832064 CB162006 AA921849 BI752085 BM698877 AA412618 BI756188 AI263488 BM314620 BM728469 CF144903 AI473214 AA952969 AI887540
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FGD4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FGD4
|
Expression
for FGD4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FGD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGATATGTG
About this image
See FGD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGD4
SOURCE GeneReport for Unigene cluster: Hs.117835
UniProtKB/Swiss-Prot: FGD4_HUMAN, Q96M96Tissue specificity: Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle,heart, uterus, placenta and testis
SABiosciences Custom PCR Arrays for FGD4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGD4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGD4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGD4 |
Orthologs
for FGD4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FGD4 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FGD41 |
FYVE, RhoGEF and PH domain containing 4 |
76.37(n)
76.72(a) |
|
418133 XM_416365.3 XP_416365.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FGD46 |
-- |
61(a) |
1 ↔ 1 |
5(10244988-10286815) |
zebrafish
(Danio rerio) |
Actinopterygii |
fgd4a1 |
FYVE, RhoGEF and PH domain containing 4a |
64.27(n)
63.65(a) |
|
556216 NM_001177933.1 NP_001171404.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
29(a) |
1 → many |
Group2.1(18879-21756) |
worm
(Caenorhabditis elegans) |
Secernentea |
exc-56 |
EXCretory canal abnormal family member (exc-5) |
18(a) |
1 → many |
IV(8799076-8804844) |
ENSEMBL Gene Tree for FGD4 (if available)
TreeFam Gene Tree for FGD4 (if available) |
Paralogs
for FGD4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FGD4 gene
- FGD32 PLEKHF22 FGD52 PLEKHF12 FGD22 FGD62 FGD12
6 SIMAP similar genes for FGD4 using alignment to 13 protein entries: FGD4_HUMAN (see all proteins):FGD2 FGD1 FLJ00004 FGD3 FGD5 FGD6
FGD4 for paralogs About GeneDecksing
|
Genomic Variants
for FGD4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FGD4 (32552463 - 32798984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FGD4
1 CNV: 8721
Human Gene Mutation Database (HGMD): FGD4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGD4 |
|
Disorders
/ Diseases
for FGD4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGD4 for disorders About GeneDecksing
OMIM gene information: 611104
OMIM disorders: 609311
UniProtKB/Swiss-Prot: FGD4_HUMAN, Q96M96
Defects in FGD4 are the cause of Charcot-Marie-Tooth disease type 4H (CMT4H) [MIM:609311]; also known asCharcot-Marie-Tooth disease neuropathy type 4H. CMT4H is a recessive demyelinating form of Charcot-Marie-Toothdisease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease isclassified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheraldemyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized byseverely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination withonion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendonreflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease aredesignated CMT4
11  diseases for FGD4: About MalaCardscharcot-marie-tooth disease type 4 charcot-marie-tooth disease charcot-marie-tooth neuropathy charcot-marie-tooth neuropathy type 4
tooth disease aarskog-scott syndrome motor peripheral neuropathy scott syndrome
peripheral neuropathy axonal neuropathy neuropathy
GeneTests: FGD4
Charcot-Marie-Tooth Neuropathy Type 4
Human Genome Epidemiology (HuGE) Navigator: FGD4 (1 document)
Export disorders for FGD4 gene to outside databases
|
Publications
for FGD4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FGD4 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with FGD4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. (PubMed id 15133042)1, 2, 9 Chen X.M....LaRusso N.F. (2004)
- Identification of splicing variants of Frabin with partly different functions and tissue distribution. (PubMed id 11527409)1, 3, 9 Ikeda W....Takai Y. (2001)
- Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. (PubMed id 17564972)1, 2, 9 Stendel C....Senderek J. (2007)
- Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H. (PubMed id 17564959)1, 2 Delague V.... Levy N. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formation. (PubMed id 11429692)1, 9 Ikeda W....Takai Y. (2001)
- Further evidence that mutations in FGD4/frabin cause Charcot-Marie-Tooth disease type 4H. (PubMed id 19332693)1, 9 Fabrizi G.M....De Jonghe P. (2009)
- A novel Frabin (FGD4) nonsense mutation p.R275X associated with phenotypic variability in CMT4H. (PubMed id 19221294)1, 9 Houlden H....Reilly M.M. (2009)
- Differential protein expression by dendritic cells fr om atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1. (PubMed id 19494521)1, 9 Horlock C....Ghaemmaghami A.M. (2009)
- Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. (PubMed id 22295116)1 Pei Y.F....Deng H.W. (2012)
|
External Searches for FGD4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FGD4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FGD4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGD4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for FGD4 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FGD4 |
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About This Section
| Patent Information for FGD4 gene:
Search GeneIP for patents involving FGD4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FGD4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for FGD4 | | OriGene shRNA RFP for FGD4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGD4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGD4 | | | OriGene Protein Over-expression Lysate for FGD4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FGD4 | | OriGene 3'-UTR Clone for FGD4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGD4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGD4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FGD4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FGD4 | | OriGene Custom Protein Services for FGD4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGD4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGD4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGD4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGD4 |
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| | | | Search Tocris compounds for FGD4 |
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 | | | FGD4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGD4 |
|  |  |  | | | | ThermoFisher Antibody for FGD4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGD4 |
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