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Aliases for FGD3 Gene

Aliases for FGD3 Gene

  • FYVE, RhoGEF And PH Domain Containing 3 2 3
  • Zinc Finger FYVE Domain-Containing Protein 5 3 4
  • FGD1 Family, Member 3 2 3
  • ZFYVE5 3 4
  • FYVE, RhoGEF And PH Domain-Containing Protein 3 3
  • Faciogenital Dysplasia 3 3
  • GCCD3 6
  • GCCD2 6

External Ids for FGD3 Gene

Previous GeneCards Identifiers for FGD3 Gene

  • GC09P086553
  • GC09P087437
  • GC09P089008
  • GC09P091051
  • GC09P091078
  • GC09P092789
  • GC09P092816
  • GC09P094749
  • GC09P095709
  • GC09P065386

Summaries for FGD3 Gene

GeneCards Summary for FGD3 Gene

FGD3 (FYVE, RhoGEF And PH Domain Containing 3) is a Protein Coding gene. Diseases associated with FGD3 include glucocorticoid deficiency 3 and aarskog-scott syndrome. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is FGD1.

UniProtKB/Swiss-Prot for FGD3 Gene

  • Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).

Gene Wiki entry for FGD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGD3 Gene

Genomics for FGD3 Gene

Regulatory Elements for FGD3 Gene

Genomic Location for FGD3 Gene

92,947,319 bp from pter
93,036,236 bp from pter
88,918 bases
Plus strand

Genomic View for FGD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGD3 Gene

Proteins for FGD3 Gene

  • Protein details for FGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FYVE, RhoGEF and PH domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • F8W7P2
    • Q4VX84
    • Q7Z7D9
    • Q8N5G1

    Protein attributes for FGD3 Gene

    725 amino acids
    Molecular mass:
    79401 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FGD3 Gene

    Alternative splice isoforms for FGD3 Gene


neXtProt entry for FGD3 Gene

Proteomics data for FGD3 Gene at MOPED

Post-translational modifications for FGD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGD3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGD3 Gene

Domains for FGD3 Gene

Gene Families for FGD3 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ZFYVE :Zinc fingers, FYVE domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q5JSP0
  • Contains 1 DH (DBL-homology) domain.
  • Contains 2 PH domains.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with FGD3: view

Function for FGD3 Gene

Molecular function for FGD3 Gene

UniProtKB/Swiss-Prot Function: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).

Gene Ontology (GO) - Molecular Function for FGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0031267 small GTPase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FGD3: view

Animal Model Products

CRISPR Products

miRNA for FGD3 Gene

miRTarBase miRNAs that target FGD3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGD3 Gene

Localization for FGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGD3 Gene

Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for FGD3 Gene COMPARTMENTS Subcellular localization image for FGD3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
golgi apparatus 4
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FGD3: view

Pathways for FGD3 Gene

genes like me logo Genes that share pathways with FGD3: view

Pathways by source for FGD3 Gene

Interacting Proteins for FGD3 Gene

Gene Ontology (GO) - Biological Process for FGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization ISS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape ISS --
GO:0030036 actin cytoskeleton organization ISS --
GO:0035023 regulation of Rho protein signal transduction --
genes like me logo Genes that share ontologies with FGD3: view

Compounds for FGD3 Gene

(1) HMDB Compounds for FGD3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with FGD3: view

Transcripts for FGD3 Gene

Unigene Clusters for FGD3 Gene

FYVE, RhoGEF and PH domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FGD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: - - - -
SP4: -
SP5: - - -

ExUns: 22a · 22b

Relevant External Links for FGD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGD3 Gene

mRNA expression in normal human tissues for FGD3 Gene

mRNA differential expression in normal tissues according to GTEx for FGD3 Gene

This gene is overexpressed in Whole Blood (34.6) and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FGD3 Gene

SOURCE GeneReport for Unigene cluster for FGD3 Gene Hs.411081

genes like me logo Genes that share expressions with FGD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FGD3 Gene

Orthologs for FGD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGD3 35
  • 99.47 (n)
  • 99.74 (a)
FGD3 36
  • 100 (a)
(Bos Taurus)
Mammalia FGD3 35
  • 82 (n)
  • 77.14 (a)
FGD3 36
  • 73 (a)
(Canis familiaris)
Mammalia FGD3 35
  • 80.67 (n)
  • 74.71 (a)
FGD3 36
  • 70 (a)
(Mus musculus)
Mammalia Fgd3 35
  • 79.44 (n)
  • 75.69 (a)
Fgd3 16
Fgd3 36
  • 74 (a)
(Monodelphis domestica)
Mammalia FGD3 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia FGD3 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Fgd3 35
  • 79.14 (n)
  • 76.17 (a)
(Gallus gallus)
Aves FGD3 35
  • 65.54 (n)
  • 64.9 (a)
FGD3 36
  • 58 (a)
(Anolis carolinensis)
Reptilia FGD3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgd3 35
  • 68.1 (n)
  • 64.76 (a)
(Danio rerio)
Actinopterygii fgd 35
  • 68.11 (n)
  • 64.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGEF4 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea exc-5 36
  • 21 (a)
exc-5 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6211 36
  • 32 (a)
Species with no ortholog for FGD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGD3 Gene

Gene Tree for FGD3 (if available)
Gene Tree for FGD3 (if available)

Paralogs for FGD3 Gene

Paralogs for FGD3 Gene

Selected SIMAP similar genes for FGD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGD3: view

Variants for FGD3 Gene

Sequence variations from dbSNP and Humsavar for FGD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1127123 -- 93,036,123(+) AAGCT(C/T)TGCTA utr-variant-3-prime
rs3802381 -- 92,976,499(+) AGTCC(A/C)TCCTC synonymous-codon, reference, nc-transcript-variant
rs3802384 - 93,006,166(+) ACGTC(A/G)TCCAC missense, reference, nc-transcript-variant
rs3936098 -- 92,949,080(+) CTTCT(C/T)CAAGC intron-variant
rs3936099 -- 92,949,362(+) CTATA(C/T)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGD3 Gene

Variant ID Type Subtype PubMed ID
nsv831654 CNV Gain 17160897
nsv526296 CNV Loss 19592680
esv989428 CNV Loss 20482838
esv2738777 CNV Deletion 23290073
esv2188240 CNV Deletion 18987734
esv2738778 CNV Deletion 23290073
esv2738779 CNV Deletion 23290073
nsv6617 CNV Insertion 18451855
nsv893575 CNV Loss 21882294
nsv521136 CNV Loss 19592680
nsv893576 CNV Gain 21882294

Relevant External Links for FGD3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGD3 Gene

Disorders for FGD3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for FGD3 Gene including...

Search for FGD3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FGD3 Gene

Relevant External Links for FGD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FGD3: view

No data available for UniProtKB/Swiss-Prot for FGD3 Gene

Publications for FGD3 Gene

  1. Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue. (PMID: 10721717) Pasteris N.G. … Gorski J.L. (Gene 2000) 3 23
  2. Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. (PMID: 18363964) Hayakawa M. … Kitagawa M. (Genes Cells 2008) 3 23
  3. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FGD3 Gene

Sources for FGD3 Gene

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