Aliases for FGD3 Gene
Aliases for FGD3 Gene
External Ids for FGD3 Gene
- HGNC: 16027
- Entrez Gene: 89846
- Ensembl: ENSG00000127084
- UniProtKB: Q5JSP0
Previous GeneCards Identifiers for FGD3 Gene
- GC09P086553
- GC09P087437
- GC09P089008
- GC09P091051
- GC09P091078
- GC09P092789
- GC09P092816
- GC09P094749
- GC09P095709
- GC09P065386
Summaries for FGD3 Gene
GeneCards Summary for FGD3 Gene
FGD3 (FYVE, RhoGEF And PH Domain Containing 3) is a Protein Coding gene. Diseases associated with FGD3 include Aarskog-Scott Syndrome and Scott Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and small GTPase binding. An important paralog of this gene is FGD1.
UniProtKB/Swiss-Prot for FGD3 Gene
-
Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGD3 Gene
Genomics for FGD3 Gene
Regulatory Elements for FGD3 Gene
Enhancers for FGD3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGD3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FGD3 gene promoter:
Regulatory Element Products
Genomic Location for FGD3 Gene
- Chromosome:
- 9
- Start:
- 92,947,319 bp from pter
- End:
- 93,036,236 bp from pter
- Size:
- 88,918 bases
- Orientation:
- Plus strand
Genomic View for FGD3 Gene
Genes around FGD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.31 by Ensembl
- 9q22.31 by Entrez Gene
- 9q22.31 by HGNC
FGD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGD3 Gene
Proteins for FGD3 Gene
-
Protein details for FGD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JSP0-FGD3_HUMAN
- Recommended name:
- FYVE, RhoGEF and PH domain-containing protein 3
- Protein Accession:
- Q5JSP0
- F8W7P2
- Q4VX84
- Q7Z7D9
- Q8N5G1
Protein attributes for FGD3 Gene
- Size:
- 725 amino acids
- Molecular mass:
- 79401 Da
- Quaternary structure:
- No Data Available
Protein Expression for FGD3 Gene
Post-translational modifications for FGD3 Gene
Other Protein References for FGD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FGD3
- Invitrogen Antibodies for FGD3
- antibodies-online Antibodies for FGD3: See all 33
- Search GeneTex for Antibodies for FGD3
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGD3
Protein Products
-
OriGene Purified Proteins for FGD3
- Search Origene for MassSpec and Protein Over-expression Lysates for FGD3
- Origene Custom Protein Services for FGD3
- antibodies-online Proteins for FGD3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGD3
Assay Products
No data available for DME Specific Peptides for FGD3 Gene
Domains & Families for FGD3 Gene
Gene Families for FGD3 Gene
Protein Domains for FGD3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FGD3 Gene
Function for FGD3 Gene
Molecular function for FGD3 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0031267 | small GTPase binding | ISS | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FGD3 Gene
- GenomeRNAi human phenotypes for FGD3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FGD3 gene
-
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- Search ViGene Biosciences for FGD3
CRISPR Products
-
OriGene CRISPR knockouts for FGD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGD3
- GenScript: Design CRISPR guide RNA sequences for FGD3
miRNA for FGD3 Gene
- miRTarBase miRNAs that target FGD3
miRNA Products
- Search ViGene Biosciences for FGD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGD3
- Browse OriGene Inhibitory RNA Products For FGD3
-
ViGene Biosciences ready-to-package AAV shRNAs for FGD3 gene
Cell Line Products
-
Horizon Cell Lines for FGD3
-
ViGene Biosciences adenoviral particle packaged cDNA for FGD3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGD3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FGD3 Gene
Localization for FGD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGD3 Gene
- Cytoplasm. Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005794 | Golgi apparatus | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for FGD3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Signaling by GPCR | ||
| 3 | Regulation of actin cytoskeleton | ||
| 4 | Actin Nucleation by ARP-WASP Complex |
.41
|
|
| 5 | Signaling by Rho GTPases | ||
Pathways by source for FGD3 Gene
10 Reactome pathways for FGD3 Gene
1 KEGG pathway for FGD3 Gene
1 Qiagen pathway for FGD3 Gene
Interacting Proteins for FGD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | ISS | -- |
| GO:0008360 | regulation of cell shape | ISS | -- |
| GO:0030036 | actin cytoskeleton organization | ISS | -- |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | -- |
| GO:0043065 | positive regulation of apoptotic process | TAS | -- |
No data available for SIGNOR curated interactions for FGD3 Gene
Drugs & Compounds for FGD3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for FGD3 Gene
mRNA/cDNA for FGD3 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGD3 Gene
- FYVE, RhoGEF and PH domain containing 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FGD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGD3
- GenScript: Design CRISPR guide RNA sequences for FGD3
miRNA Products
- Search ViGene Biosciences for FGD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGD3
- Browse OriGene Inhibitory RNA Products For FGD3
-
ViGene Biosciences ready-to-package AAV shRNAs for FGD3 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22a | · | 22b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: |
Expression for FGD3 Gene
mRNA differential expression in normal tissues according to GTEx for FGD3 Gene
This gene is overexpressed in Whole Blood (x34.6) and Spleen (x4.2).
This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Lymph node (14.2), Monocytes (8.7), and NK cells (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGD3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FGD3 Gene:
FGD3SOURCE GeneReport for Unigene cluster for FGD3 Gene:
Hs.411081Evidence on tissue expression from TISSUES for FGD3 Gene
- Blood(4.6)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for FGD3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGD3 Gene
Orthologs for FGD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGD3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGD3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGD3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgd3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgd3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGD3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FGD3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGD3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGD3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgd3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgd 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RhoGEF4 35 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | exc-5 36 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6211 35 |
|
OneToMany |
- Species where no ortholog for FGD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FGD3 Gene
Variants for FGD3 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000065343 | -- | 93,026,167(+) | GCCCC(A/G)TTGGC | intron-variant | |
| rs1000077724 | -- | 93,023,415(+) | CTTGC(A/G)CATAC | intron-variant | |
| rs1000115473 | -- | 92,982,482(+) | TTCCC(G/T)TCCTT | intron-variant | |
| rs1000119855 | -- | 92,975,305(+) | CTACC(A/G)TGTGC | nc-transcript-variant, utr-variant-5-prime | |
| rs1000158829 | -- | 93,011,074(+) | AGTCC(C/T)CTAGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2188240 | CNV | deletion | 18987734 |
| esv2738777 | CNV | deletion | 23290073 |
| esv2738778 | CNV | deletion | 23290073 |
| esv2738779 | CNV | deletion | 23290073 |
| esv3545134 | CNV | deletion | 23714750 |
| esv989428 | CNV | loss | 20482838 |
| nsv1077164 | CNV | deletion | 25765185 |
| nsv1124449 | CNV | deletion | 24896259 |
| nsv1137663 | CNV | deletion | 24896259 |
| nsv521136 | CNV | loss | 19592680 |
| nsv526296 | CNV | loss | 19592680 |
| nsv6617 | CNV | insertion | 18451855 |
| nsv831654 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.93;
35.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGD3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGD3 Gene
Disorders for FGD3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aarskog-scott syndrome |
|
|
| scott syndrome |
|
|
Search FGD3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FGD3
No data available for UniProtKB/Swiss-Prot and Genatlas for FGD3 Gene
Publications for FGD3 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. (PMID: 18363964) Hayakawa M. … Kitagawa M. (Genes Cells 2008) 3 22 64
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 64
Products for FGD3 Gene
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- antibodies-online Antibodies for FGD3: See all 33
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- antibodies-online Proteins for FGD3: See all 6
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- ViGene Biosciences adenoviral particle packaged cDNA for FGD3 gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer