Aliases for FGD2 Gene
External Ids for FGD2 Gene
Previous GeneCards Identifiers for FGD2 Gene
GeneCards Summary for FGD2 Gene
FGD2 (FYVE, RhoGEF And PH Domain Containing 2) is a Protein Coding gene. Diseases associated with FGD2 include Glucocorticoid Deficiency 2. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and small GTPase binding. An important paralog of this gene is FGD1.
UniProtKB/Swiss-Prot for FGD2 Gene
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).