Aliases for FGD2 Gene
External Ids for FGD2 Gene
Previous GeneCards Identifiers for FGD2 Gene
GeneCards Summary for FGD2 Gene
FGD2 (FYVE, RhoGEF And PH Domain Containing 2) is a Protein Coding gene. Diseases associated with FGD2 include glucocorticoid deficiency 2. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and small GTPase binding. An important paralog of this gene is FGD1.
UniProtKB/Swiss-Prot for FGD2 Gene
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).