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FGD2 Gene

protein-coding   GIFtS: 54
GCID: GC06P036973

FYVE, RhoGEF And PH Domain Containing 2

(Previous names: FGD1 family, member 2)
  See FGD2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FYVE, RhoGEF And PH Domain Containing 21 2
FGD1 Family, Member 21 2
Zinc Finger FYVE Domain-Containing Protein 42 3
ZFYVE42 3
FLJ00276 Protein2
FYVE, RhoGEF And PH Domain-Containing Protein 22

External Ids:    HGNC: 36641   Entrez Gene: 2214722   Ensembl: ENSG000001461927   OMIM: 6050915   UniProtKB: Q7Z6J43   

Export aliases for FGD2 gene to outside databases

Previous GC identifers: GC06U990176 GC06P036970 GC06P037020 GC06P037081 GC06P036691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FGD2 Gene:
FGD2 (FYVE, RhoGEF and PH domain containing 2) is a protein-coding gene. Diseases associated with FGD2 include glucocorticoid deficiency 2. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHF2.

UniProtKB/Swiss-Prot: FGD2_HUMAN, Q7Z6J4
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for
free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate,
phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol
4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)

Gene Wiki entry for FGD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGD2 gene promoter:
         HOXA3   Pax-5   AML1a   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   CREB   deltaCREB   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGD2 promoter sequence
   Search Chromatin IP Primers for FGD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

FGD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGD2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036973:  view genomic region     (about GC identifiers)

Start:
36,973,422 bp from pter      End:
36,996,846 bp from pter
Size:
23,425 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGD2_HUMAN, Q7Z6J4 (See protein sequence)
Recommended Name: FYVE, RhoGEF and PH domain-containing protein 2  
Size: 655 amino acids; 74892 Da
Sequence caution: Sequence=BAB15746.1; Type=Erroneous initiation; Sequence=BAC85129.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=BAC85129.1; Type=Frameshift; Positions=460;
Sequence=CAI20471.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T8I1 Q6P6A8 Q6ZNL5 Q8IZ32 Q8N868 Q9H7M2
Alternative splicing: 4 isoforms:  Q7Z6J4-1   Q7Z6J4-2   Q7Z6J4-4   Q7Z6J4-5   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FGD2: NX_Q7Z6J4

Explore proteomics data for FGD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775829.2  
    ENSEMBL proteins: 
     ENSP00000274963   ENSP00000419657   ENSP00000362635  
    Reactome Protein details: Q7Z6J4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 7):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR000306 Znf_FYVE
     IPR011993 PH_like_dom
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q7Z6J4

    ProtoNet protein and cluster: Q7Z6J4

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB000306 Zn-finger
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: FGD2_HUMAN, Q7Z6J4
    Domain: The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes
    via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By
    similarity)
    Domain: The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs
    through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding
    properties of the protein (By similarity)
    Domain: The DH domain is necessary for its ability to activate JNK1 via CDC42 (By similarity)
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 2 PH domains


    Find genes that share domains with FGD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGD2_HUMAN, Q7Z6J4
    Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for
    free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate,
    phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol
    4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)

         Genatlas biochemistry entry for FGD2:
    Rho GEF (guanine nucleotide exchange factor) 2,homolog of FGD1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0031267small GTPase binding ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FGD2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fgd2):
     reproductive system 

    Find genes that share phenotypes with FGD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fgd2tm1Bgh for FGD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGD2
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    miRNA
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    hsa-mir-335-5p (MIRT017089)

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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGD2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGD2_HUMAN, Q7Z6J4: Cytoplasm, cytoskeleton (Probable). Cytoplasm (By similarity). Nucleus (By similarity).
    Early endosome (By similarity). Early endosome membrane (By similarity). Cell projection, ruffle membrane (By
    similarity). Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    golgi apparatus4
    endosome2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus ISS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FGD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGD2 About    
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4Signaling by FGFR
    Signalling by NGF0.71


    Find genes that share SuperPaths with FGD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for FGD2
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGD2
    Interactions:

        Search GeneGlobe Interaction Network for FGD2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FGD2 (Q7Z6J43 ENSP000002749634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RNPS1Q152873, ENSP000003158594I2D: score=1 STRING: ENSP00000315859
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ISS--
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0008360regulation of cell shape ISS--
    GO:0030036actin cytoskeleton organization ISS--
    GO:0035023regulation of Rho protein signal transduction ----

    Find genes that share ontologies with FGD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGD2

    1 HMDB Compound for FGD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGD2 gene: 
    NM_173558.3  

    Unigene Cluster for FGD2:

    FYVE, RhoGEF and PH domain containing 2
    Hs.509664  [show with all ESTs]
    Unigene Representative Sequence: BC023645
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489356(uc003onf.3) ENST00000274963(uc010jwp.1 uc003ong.2 uc011dtv.1)
    ENST00000497659 ENST00000373535 ENST00000459781 ENST00000487975(uc011dtu.1)
    ENST00000464083 ENST00000494343(uc003oni.1) ENST00000470273 ENST00000493635
    ENST00000487920(uc003onj.1)
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      QuantiFast Probe-based Assays in human, mouse, rat FGD2

    Additional mRNA sequence: 

    AK290419.1 AK300964.1 AK301156.1 BC023645.2 BC053655.1 BX648164.1 

    6 DOTS entries:

    DT.91748862  DT.100018798  DT.100030953  DT.100675094  DT.100774684  DT.40311561 

    Selected AceView cDNA sequences (see all 49):

    CB266766 AA825628 BQ708371 AI524250 BF909099 AK092732 CD366726 AK024456 
    AK131079 AA749152 BX115167 AX747694 BC062363 BC053655 BG686784 BX105773 
    BQ711182 BX648164 CA392949 BF884079 AK097230 BX510116 AI568774 AK097981 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGD2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                      -     -                       -                                                                           
    SP2:                                      -     -                                                                                                   
    SP3:                                                                    -                                                                           
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for FGD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FGD2 Expression
    About this image


    FGD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    FGD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509664
        Custom PCR Arrays for FGD2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FGD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgd21 , 5 FYVE, RhoGEF and PH domain containing 21, 5 83(n)1
    81.82(a)1
      17 (15.26 cM)5
    263821  NM_013710.41  NP_038738.21 
     293609145 
    lizard
    (Anolis carolinensis)
    Reptilia FGD26
    FYVE, RhoGEF and PH domain containing 2
    63(a)
    1 ↔ 1
    GL343382.1(6742-23155)
    zebrafish
    (Danio rerio)
    Actinopterygii fgd6
    faciogenital dysplasia
    33(a)
    1 ↔ 1
    8(55592960-55599119) ENSDARG00000090746
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGEF46
    RhoGEF4
    17(a)
    many ↔ many
    3L(7314199-7316511)
    worm
    (Caenorhabditis elegans)
    Secernentea exc-51 exc-5 42.24(n)
    31.77(a)
      177692  NM_001027867.2  NP_001023038.1 


    ENSEMBL Gene Tree for FGD2 (if available)
    TreeFam Gene Tree for FGD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGD2 gene
    PLEKHF22  FGD32  FGD52  PLEKHF12  FGD62  FGD42  FGD12  
    5 SIMAP similar genes for FGD2 using alignment to 3 protein entries:     FGD2_HUMAN (see all proteins):
    FGD4    FGD1    FLJ00004    FGD3    FGD6

    Find genes that share paralogs with FGD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGD2 (see all 754)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456490361,2
    --36971488(+) CACCTA/GTAGTC 1 -- us2k10--------
    rs1465669801,2
    --36971526(+) GAATCC/GCTTGA 1 -- us2k10--------
    rs1491671601,2
    C--36971561(+) GATCCA/GAGATT 1 -- us2k10--------
    rs1435260391,2
    C--36971566(+) GAGATC/TGCAGC 1 -- us2k10--------
    rs1480317271,2
    --36971570(+) TTGCAC/GCACTG 1 -- us2k10--------
    rs1838676001,2
    --36971594(+) GTGACA/GGAGTA 1 -- us2k10--------
    rs114487321,2
    C--36971625(+) AAAAA-/GAGAGA 1 -- us2k1 trp30--------
    rs1888745131,2
    --36971642(+) GTTCTC/TATCTT 1 -- us2k10--------
    rs1923781471,2
    C--36971648(+) ATCTTC/TTAGAT 1 -- us2k10--------
    rs1138197721,2
    C--36971691(+) GACATC/TTGGGA 1 -- us2k12Minor allele frequency- T:0.02CSA WA 120

    HapMap Linkage Disequilibrium report for FGD2 (36973422 - 36996846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FGD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515488CNV Loss19592680
    nsv885816CNV Loss21882294
    nsv885815CNV Loss21882294
    nsv518386CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGD2
    DNA2.0 Custom Variant and Variant Library Synthesis for FGD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605091    OMIM disorders: --

    1 disease for FGD2:    
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    glucocorticoid deficiency 2


    Find genes that share disorders with FGD2           About GenesLikeMe


    Export disorders for FGD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGD2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with FGD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues. (PubMed id 10458911)1, 3, 9 Pasteris N.G. and Gorski J.L. (Genomics 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    6. FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. (PubMed id 18838382)1 Huber C....Gavin A.L. (J. Biol. Chem. 2008)
    7. Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H. (PubMed id 17564959)1 Delague V.... Levy N. (Am. J. Hum. Genet. 2007)
    8. Large-scale analysis of the human ubiquitin-related proteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (Proteomics 2005)
    9. Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). (PubMed id 12787561)1 Rabizadeh S. and Bredesen D.E. (amp 2003)
    10. NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. (PubMed id 12376548)1 Salehi A.H....Barker P.A. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221472 HGNC: 3664 AceView: FGD2 Ensembl:ENSG00000146192 euGenes: HUgn221472
    ECgene: FGD2 H-InvDB: FGD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGD2 gene:
    Search GeneIP for patents involving FGD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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