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FGB Gene

protein-coding   GIFtS: 69
GCID: GC04P155484

Fibrinogen Beta Chain

(Previous names: fibrinogen, B beta polypeptide)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibrinogen Beta Chain1 2
Fibrinogen, B Beta Polypeptide1 2
HEL-S-78p2
Epididymis Secretory Sperm Binding Protein Li 78p2

External Ids:    HGNC: 36621   Entrez Gene: 22442   Ensembl: ENSG000001715647   OMIM: 1348305   UniProtKB: P026753   

Export aliases for FGB gene to outside databases

Previous GC identifers: GC04P156333 GC04P155872 GC04P155950 GC04P156061 GC04P155841 GC04P155703 GC04P151224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGB Gene:
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of
three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to
form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of
fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities,
and are mitogens for several cell types. Mutations in this gene lead to several disorders, including
afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGB Gene:
FGB (fibrinogen beta chain) is a protein-coding gene. Diseases associated with FGB include dysfibrinogenemia, beta type, and fgb-related congenital afibrinogenemia. GO annotations related to this gene include chaperone binding and receptor binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
in platelet aggregation

Gene Wiki entry for FGB (Fibrinogen beta chain) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGB gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   NF-AT   NF-AT4   NF-AT2   NF-AT3   ZIC2/Zic2   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGB promoter sequence
   Search Chromatin IP Primers for FGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q28

FGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P155484:  view genomic region     (about GC identifiers)

Start:
155,484,108 bp from pter      End:
155,493,915 bp from pter
Size:
9,808 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675 (See protein sequence)
Recommended Name: Fibrinogen beta chain precursor  
Size: 491 amino acids; 55928 Da
Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2
heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity)
Selected PDB 3D structures from and Proteopedia for FGB (see all 31):
1FZA (3D)        1FZB (3D)        1FZC (3D)        1FZE (3D)        1FZF (3D)        1FZG (3D)    
Secondary accessions: B2R7G3 Q3KPF2

Explore the universe of human proteins at neXtProt for FGB: NX_P02675

Explore proteomics data for FGB at MOPED

Post-translational modifications: 

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and
    beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
    The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine
    cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers1
  • Glycosylation2 at Asn394
  • Modification sites at PhosphoSitePlus

  • See FGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171670.1  NP_005132.2  

    ENSEMBL proteins: 
     ENSP00000306099   ENSP00000398719   ENSP00000426757  
    Reactome Protein details: P02675

    FGB Human Recombinant Protein Products:

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    Novus Biologicals FGB Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    FGB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FGB
    R&D Systems Antibodies for FGB (Fibrinogen)
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    FGB Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR012290 Fibrinogen_a/b/g_coil_dom
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry P02675

    ProtoNet protein and cluster: P02675

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675
    Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal
    domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to
    the coiled coil structure
    Similarity: Contains 1 fibrinogen C-terminal domain


    FGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIBB_HUMAN, P02675
    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
    in platelet aggregation

         Genatlas biochemistry entry for FGB:
    fibrinogen,beta polypeptide, (see FG@)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI--
    GO:0030674protein binding, bridging IEA--
    GO:0051087chaperone binding IPI19996109
         
    FGB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGB

    miRNA
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    miRTarBase miRNAs that target FGB:
    hsa-mir-29b-3p (MIRT005534), hsa-mir-409-3p (MIRT005517), hsa-mir-29a-3p (MIRT005532), hsa-mir-144-3p (MIRT005530), hsa-mir-29c-3p (MIRT005526)

    Block miRNA regulation of human, mouse, rat FGB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGB (see all 18):
    hsa-miR-148b* hsa-miR-137 hsa-miR-25 hsa-miR-3150a-3p hsa-miR-3119 hsa-miR-3909 hsa-miR-92b hsa-miR-299-5p
    SwitchGear 3'UTR luciferase reporter plasmidFGB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGB
    Predesigned siRNA for gene silencing in human, mouse, rat FGB

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FGB (NM_005141)
    Sino Biological Human cDNA Clone for FGB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGB

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FGB 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIBB_HUMAN, P02675: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IEA--
    GO:0005615extracellular space IDA19996109
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--

    FGB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGB About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Common Pathway0.00
    Blood Coagulation Signaling Pathways0.51
    Extrinsic Prothrombin Activation Pathway0.00
    Blood Clotting Cascade0.42
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    3Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    GRB2-SOS provides linkage to MAPK signaling for Intergrins0.00
    Platelet Aggregation (Plug Formation)0.73
    p130Cas linkage to MAPK signaling for integrins0.00
    4Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    5Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FGB
        Blood Coagulation Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGB
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 GeneGo (Thomson Reuters) Pathways for FGB
        Cell adhesion Integrin inside-out signaling
    Cell adhesion Plasmin signaling

    2 BioSystems Pathways for FGB
        Blood Clotting Cascade
    Complement and Coagulation Cascades


    Selected Reactome Pathways for FGB (see all 6)
        Integrin cell surface interactions
    Platelet degranulation
    Integrin alphaIIb beta3 signaling
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Integrins

    1 PharmGKB Pathway for FGB
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for FGB):
        Complement and coagulation cascades


    FGB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGB: 
              Nephrotoxicity in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGB (P026751, 2, 3 ENSP000003060994) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271146 I2D: score=2 
    SMN2Q166372, 3MINT-8271146 I2D: score=2 
    AIMP2Q131552, 3MINT-8258882 I2D: score=2 
    ANXA7P200732, 3MINT-8248362 I2D: score=2 
    CDKN1AP389362, 3MINT-8251893 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0030198extracellular matrix organization TAS--

    FGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGB (FIBB)

    1 DrugBank Compound for FGB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sucralfate-- 54182-58-0targetantagonist6892775

    9 Novoseek inferred chemical compound relationships for FGB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 88.7 91 9753458 (2), 10712387 (2), 18331453 (2), 12871501 (2) (see all 60)
    batroxobin 78.3 3 9397156 (1), 12805063 (1), 1799661 (1)
    hirudin 56.6 6 11142354 (2), 9868910 (1), 7923685 (1)
    rsai 55 1 15795544 (1)
    serine 32.1 2 11910192 (1), 17982312 (1)
    heparin 26.5 1 8822924 (1)
    calcium 2.39 5 15572240 (2), 14764520 (1), 8331664 (1)
    nacl 0 1 8605191 (1)
    tyrosine 0 2 9311149 (1), 9753458 (1)



    FGB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGB gene (2 alternative transcripts): 
    NM_001184741.1  NM_005141.4  

    Unigene Cluster for FGB:

    Fibrinogen beta chain
    Hs.300774  [show with all ESTs]
    Unigene Representative Sequence: NM_005141
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302068(uc003ioa.4 uc010ipv.3) ENST00000498375(uc010ipu.1)
    ENST00000497097 ENST00000425838 ENST00000509493 ENST00000502545 ENST00000473984


    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGB (see all 18):
    hsa-miR-148b* hsa-miR-137 hsa-miR-25 hsa-miR-3150a-3p hsa-miR-3119 hsa-miR-3909 hsa-miR-92b hsa-miR-299-5p
    SwitchGear 3'UTR luciferase reporter plasmidFGB 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FGB (NM_005141)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGB
    Primer
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    OriGene qPCR primer pairs and template standards for FGB
    OriGene qSTAR qPCR primer pairs in human, mouse for FGB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGB
      QuantiTect SYBR Green Assays in human, mouse, rat FGB
      QuantiFast Probe-based Assays in human, mouse, rat FGB

    Additional mRNA sequence: 

    AK303788.1 AK309592.1 AK312972.1 BC007030.1 BC036007.1 BC070245.1 BC106760.2 BC107766.1 
    J00129.1 J00133.1 

    Selected DOTS entries (see all 47):

    DT.454371  DT.95378916  DT.100890715  DT.100890713  DT.121235436  DT.91770011  DT.100890732  DT.121235387 
    DT.91848881  DT.91740978  DT.121235433  DT.91770029  DT.220241  DT.91755645  DT.91770005  DT.91770002 
    DT.95165598  DT.100890697  DT.100890754  DT.100890748  DT.100045220  DT.100890696  DT.100890699  DT.100890723 

    Selected AceView cDNA sequences (see all 950):

    CR615982 CR618890 AL531454 CR597369 CR623707 CB122990 CR622186 CR592797 
    BX427241 CB120349 AW952923 AI174982 CB146585 CR594367 CR593920 CB154260 
    CR613846 CR600529 CB134917 BX366992 CR594718 AL531720 CR614404 CR623793 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGAAAGGA
    FGB Expression
    About this image


    FGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Hepatocyte-like cells
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Lung (Respiratory System)
    FGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300774
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGB: 
              Nephrotoxicity in human mouse rat
              Atherosclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FGB
    OriGene qSTAR qPCR primer pairs in human, mouse for FGB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGB
    QuantiTect SYBR Green Assays in human, mouse, rat FGB
    QuantiFast Probe-based Assays in human, mouse, rat FGB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FGB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgb1 , 5 fibrinogen beta chain1, 5 83.19(n)1
    84.62(a)1
      3 (36.98 cM)5
    1101351  NM_181849.21  NP_862897.11 
     830423035 
    chicken
    (Gallus gallus)
    Aves FGB1 fibrinogen beta chain 69.97(n)
    66.88(a)
      373926  NM_001167683.1  NP_001161155.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGB6
    fibrinogen beta chain
    62(a)
    1 ↔ 1
    5(130267188-130279641)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978252 B fibrinopeptide 79.4(n)    BC054326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgb1 fibrinogen, B beta polypeptide 59.72(n)
    57.62(a)
      337315  NM_212774.1  NP_997939.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG415206
    --
    15(a)
    1 → many
    U(1242085-1369506)


    ENSEMBL Gene Tree for FGB (if available)
    TreeFam Gene Tree for FGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGB gene
    FGL22  ANGPT42  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  
    FCN12  ANGPT12  ANGPTL12  ANGPTL72  ANGPT22  MFAP42  FGL12  
    13 SIMAP similar genes for FGB using alignment to 6 protein entries:     FIBB_HUMAN (see all proteins):
    FGA    FGL1    FGG    DKFZp779N0926    LFIRE1    FCN3
    ANGPTL2    MFAP4    ANGPTL7    ANGPTL6    FCN1    ANGPT1
    FCN2

    FGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGB (see all 329)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0169084
    Congenital afibrinogenemia (CAFBN)4--see VAR_0169082 R C mis40--------
    VAR_0169104
    Congenital afibrinogenemia (CAFBN)4--see VAR_0169102 G D mis40--------
    VAR_0169094
    Congenital afibrinogenemia (CAFBN)4--see VAR_0169092 L R mis40--------
    rs1219096251,2
    Cpathogenic1155279512(+) GTCATC/TGACCC 4 R * stg11Minor allele frequency- T:0.00EU 1321
    rs1219096161,2
    Cother1155279503(+) GTGCCC/TGTGGT 4 R C mis10--------
    rs42201,2,,4
    C,F,A,Hother1155284287(+) AATGAG/AGAAGA 4 /K /R mis1 ese338Minor allele frequency- A:0.16MN NS EA NA WA EU 14345
    rs22274371,2
    F--151230709(+) aaaaaA/Gaaaaa 2 -- int1 trp32Minor allele frequency- G:0.02NS 92
    rs1908564861,2
    --155274725(+) AGCCAA/GTTCAC 2 -- us2k10--------
    rs1826578591,2
    --155274799(+) CAGCCC/TCTATC 2 -- us2k10--------
    rs773272651,2
    C,F--155274814(+) TACCCG/ATCACT 2 -- us2k11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for FGB (155484108 - 155493915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5783n71CNV Loss21882294
    nsv880875CNV Gain21882294
    dgv5784n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): FGB
    Locus Specific Mutation Databases (LSDB): FGB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGB
    DNA2.0 Custom Variant and Variant Library Synthesis for FGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134830   
    OMIM disorders: 202400  
    UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by
    bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet
    fibrinogen. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with
    congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent,
    some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding

  • Selected diseases for FGB (see all 68):    
    About MalaCards
    dysfibrinogenemia, beta type    fgb-related congenital afibrinogenemia    afibrinogenemia    thrombophilia, dysfibrinogenemic
    dysfibrinogenemia    carotid intimal medial thickness    congenital afibrinogenemia    chronic thromboembolic pulmonary hypertension
    hepatitis e    pulmonary embolism    portal hypertension    peripheral vascular disease
    venous thrombosis    thromboembolism    retinal vein occlusion    cerebral palsy
    pregnancy loss    familial hypercholesterolemia    thrombophilia    venous thromboembolism

    1 disease from the University of Copenhagen DISEASES database for FGB:
    Congenital afibrinogenemia

    FGB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for FGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital afibrinogenemia 95 2 12511408 (1), 10891444 (1)
    afibrinogenemia 93.7 9 18853456 (2), 12511408 (1), 19551918 (1), 16999847 (1) (see all 6)
    hypofibrinogenemia 79.2 1 18676163 (1)
    coagulopathy 41.8 2 18676163 (1), 19551918 (1)
    myocardial infarction 22.8 2 16525568 (1), 18278190 (1)
    venous thrombosis 10 1 12893031 (1)
    pulmonary embolism 0 2 12893031 (2)

    Genetic Association Database (GAD): FGB
    Human Genome Epidemiology (HuGE) Navigator: FGB (196 documents)

    Export disorders for FGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGB gene, integrated from 10 sources (see all 457):
    (articles sorted by number of sources associating them with FGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PubMed id 20167083)1, 4, 9 Theodoraki E.V....Dedoussis G.V. (BMC Med. Genet. 2010)
    2. Fibrinogen gene variation and ischemic stroke. (PubMed id 18331453)1, 4, 9 Jood K....Jern C. (J. Thromb. Haemost. 2008)
    3. Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. (PubMed id 15983960)1, 4, 9 Liu Y....Coresh J. (Am. J. Kidney Dis. 2005)
    4. Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms. (PubMed id 19750100)1, 4, 9 Ljungman P....Peters A. (Environ. Health Perspect. 2009)
    5. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. (PubMed id 19136375)1, 4, 9 Peters A....Wichmann H.E. (Am. J. Respir. Crit. Care Med. 2009)
    6. [Complex analysis of genetic predisposition to ischemic stroke in Russians]. (PubMed id 19899640)1, 4, 9 Parfenov M.G....Favorova O.O. (Mol. Biol. (Mosk.) 2009)
    7. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. (PubMed id 17469143)1, 4, 9 Gong R....Li L. (Arthritis Rheum. 2007)
    8. A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine. (PubMed id 2018836)1, 2, 9 Yoshida N.... Shirakawa S. (Blood 1991)
    9. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PubMed id 20059469)1, 4, 9 Carty C.L....Reiner A.P. (Ann. Hum. Genet. 2010)
    10. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PubMed id 18278190)1, 4, 9 Carty C.L....Reiner A.P. (Thromb. Haemost. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2244 HGNC: 3662 AceView: FGB Ensembl:ENSG00000171564 euGenes: HUgn2244
    ECgene: FGB Kegg: 2244 H-InvDB: FGB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGB Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FGB[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FGB
    Wikipedia http://en.wikipedia.org/wiki/Fibrinogen
    SeattleSNPshttp://pga.gs.washington.edu/data/fgb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGB gene:
    Search GeneIP for patents involving FGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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