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Aliases for FGB Gene

Aliases for FGB Gene

  • Fibrinogen Beta Chain 2 3 5
  • Fibrinogen, B Beta Polypeptide 2 3
  • Epididymis Secretory Sperm Binding Protein Li 78p 3
  • Beta-Fibrinogen 3
  • HEL-S-78p 3

External Ids for FGB Gene

Previous GeneCards Identifiers for FGB Gene

  • GC04P156333
  • GC04P155872
  • GC04P155950
  • GC04P156061
  • GC04P155841
  • GC04P155703
  • GC04P155484
  • GC04P151224

Summaries for FGB Gene

Entrez Gene Summary for FGB Gene

  • The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for FGB Gene

FGB (Fibrinogen Beta Chain) is a Protein Coding gene. Diseases associated with FGB include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital. Among its related pathways are RET signaling and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include receptor binding and chaperone binding. An important paralog of this gene is FGG.

UniProtKB/Swiss-Prot for FGB Gene

  • Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGB Gene

Genomics for FGB Gene

Regulatory Elements for FGB Gene

Enhancers for FGB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F154598 1 FANTOM5 19.1 +35.3 35298 0.2 ELF3 ATF1 MLX ARID4B THRB RAD21 DNMT3B RARA YY1 GATA4 FGA FGB FGG LRAT
GH04F154529 0.4 ENCODE 10.4 -33.0 -33005 1.2 CEBPB FGB PLRG1 LOC100128050 GC04M154544 RNU6-1285P
GH04F154615 0.4 FANTOM5 4 +52.5 52494 0.1 YY1 FGB FGA FGG LRAT
GH04F154559 1 ENCODE 0.8 -2.5 -2516 1.7 ATF1 MLX ARID4B SIN3A ZNF48 YY1 ZNF143 SP5 NFYC JUNB FGG PLRG1 DCHS2 FGB LOC100422640
GH04F154589 1.3 Ensembl ENCODE 0.3 +27.8 27791 3.5 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 PAF1 SP5 NFYC MIER2 FGG LRAT FGA FGB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGB on UCSC Golden Path with GeneCards custom track

Genomic Location for FGB Gene

Chromosome:
4
Start:
154,562,956 bp from pter
End:
154,572,763 bp from pter
Size:
9,808 bases
Orientation:
Plus strand

Genomic View for FGB Gene

Genes around FGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGB Gene

Proteins for FGB Gene

  • Protein details for FGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02675-FIBB_HUMAN
    Recommended name:
    Fibrinogen beta chain
    Protein Accession:
    P02675
    Secondary Accessions:
    • A0JLR9
    • B2R7G3
    • Q32Q65
    • Q3KPF2

    Protein attributes for FGB Gene

    Size:
    491 amino acids
    Molecular mass:
    55928 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
    SequenceCaution:
    • Sequence=AAH07030.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGB Gene

neXtProt entry for FGB Gene

Post-translational modifications for FGB Gene

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Glycosylation at Asn 394
  • Modification sites at PhosphoSitePlus

Other Protein References for FGB Gene

No data available for DME Specific Peptides for FGB Gene

Domains & Families for FGB Gene

Graphical View of Domain Structure for InterPro Entry

P02675

UniProtKB/Swiss-Prot:

FIBB_HUMAN :
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGB: view

Function for FGB Gene

Molecular function for FGB Gene

GENATLAS Biochemistry:
fibrinogen,beta polypeptide, (see FG@)
UniProtKB/Swiss-Prot Function:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Ontology (GO) - Molecular Function for FGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 contributes_to receptor binding IDA 10903502
GO:0005198 structural molecule activity IDA 8910396
GO:0005515 protein binding IPI 12706644
GO:0030674 protein binding, bridging IEA --
GO:0050839 contributes_to cell adhesion molecule binding IDA 9182580
genes like me logo Genes that share ontologies with FGB: view
genes like me logo Genes that share phenotypes with FGB: view

Human Phenotype Ontology for FGB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGB Gene

MGI Knock Outs for FGB:
  • Fgb tm1.1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FGB

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGB Gene

Localization for FGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGB gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005577 fibrinogen complex IEA,IDA 6688356
GO:0005615 extracellular space IDA 6777381
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FGB: view

Pathways & Interactions for FGB Gene

SuperPathway Contained pathways
1 RET signaling
2 Formation of Fibrin Clot (Clotting Cascade)
3 Integrin alphaIIb beta3 signaling
4 Response to elevated platelet cytosolic Ca2+
5 Complement and coagulation cascades
genes like me logo Genes that share pathways with FGB: view

Gene Ontology (GO) - Biological Process for FGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002576 platelet degranulation TAS --
GO:0007160 cell-matrix adhesion IDA 10903502
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with FGB: view

No data available for SIGNOR curated interactions for FGB Gene

Drugs & Compounds for FGB Gene

(7) Drugs for FGB Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucralfate Approved Pharma Target, antagonist 10
Alfimeprase Investigational Pharma Target 0
RECOMBINANT FACTOR IX FC FUSION PROTEIN Pharma 0

(5) Additional Compounds for FGB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGB: view

Transcripts for FGB Gene

Unigene Clusters for FGB Gene

Fibrinogen beta chain:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FGB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGB Gene

No ASD Table

Relevant External Links for FGB Gene

GeneLoc Exon Structure for
FGB
ECgene alternative splicing isoforms for
FGB

Expression for FGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGB Gene

mRNA differential expression in normal tissues according to GTEx for FGB Gene

This gene is overexpressed in Liver (x52.7).

Protein differential expression in normal tissues from HIPED for FGB Gene

This gene is overexpressed in Synovial fluid (10.1) and Lavage (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGB Gene



Protein tissue co-expression partners for FGB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FGB Gene:

FGB

SOURCE GeneReport for Unigene cluster for FGB Gene:

Hs.300774

mRNA Expression by UniProt/SwissProt for FGB Gene:

P02675-FIBB_HUMAN
Tissue specificity: Detected in blood plasma (at protein level).
genes like me logo Genes that share expression patterns with FGB: view

Orthologs for FGB Gene

This gene was present in the common ancestor of animals.

Orthologs for FGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGB 34
  • 99.39 (n)
BETA-FIBRINOGEN 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGB 34 35
  • 87.64 (n)
cow
(Bos Taurus)
Mammalia FGB 34 35
  • 85.11 (n)
mouse
(Mus musculus)
Mammalia Fgb 34 16 35
  • 83.19 (n)
rat
(Rattus norvegicus)
Mammalia Fgb 34
  • 80.92 (n)
oppossum
(Monodelphis domestica)
Mammalia FGB 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGB 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGB 34 35
  • 69.97 (n)
lizard
(Anolis carolinensis)
Reptilia FGB 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgb 34
  • 67.55 (n)
Str.8476 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397825 34
zebrafish
(Danio rerio)
Actinopterygii fgb 34 35
  • 59.72 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10534 34
fruit fly
(Drosophila melanogaster)
Insecta CG41520 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for FGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGB Gene

ENSEMBL:
Gene Tree for FGB (if available)
TreeFam:
Gene Tree for FGB (if available)

Paralogs for FGB Gene

genes like me logo Genes that share paralogs with FGB: view

Variants for FGB Gene

Sequence variations from dbSNP and Humsavar for FGB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs121909620 Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004], other 154,565,985(+) TTCAC(A/G)CTGAC intron-variant, reference, missense
rs121909621 Congenital afibrinogenemia (CAFBN) [MIM:202400], Pathogenic 154,569,703(+) TGCCC(G/T)CATGG reference, missense
rs121909622 Congenital afibrinogenemia (CAFBN) [MIM:202400], Pathogenic 154,570,463(+) CGGTG(A/G)TGGAT reference, missense
rs121909623 Congenital afibrinogenemia (CAFBN) [MIM:202400], other 154,567,688(+) ACCTT(C/T)GTGTG reference, missense
rs121909624 Congenital afibrinogenemia (CAFBN) [MIM:202400], Pathogenic 154,567,707(+) AATCC(A/T)GGAAA reference, missense

Variation tolerance for FGB Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGB Gene

Human Gene Mutation Database (HGMD)
FGB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FGB Gene

Disorders for FGB Gene

MalaCards: The human disease database

(11) MalaCards diseases for FGB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
afibrinogenemia, congenital
  • hypofibrinogenemia, congenital
dysfibrinogenemia, congenital
  • hypodysfibrinogenemia, congenital
afibrinogenemia
  • congenital afibrinogenemia
fgb-related congenital afibrinogenemia
dysfibrinogenemia
  • congenital dysfibrinogenemia
- elite association - COSMIC cancer census association via MalaCards
Search FGB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FIBB_HUMAN
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:10666208, ECO:0000269 PubMed:11468164, ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:1634610}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGB

Genetic Association Database (GAD)
FGB
Human Genome Epidemiology (HuGE) Navigator
FGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGB
genes like me logo Genes that share disorders with FGB: view

No data available for Genatlas for FGB Gene

Publications for FGB Gene

  1. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PMID: 20059469) Carty C.L. … Reiner A.P. (Ann. Hum. Genet. 2010) 3 22 46 64
  2. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PMID: 20167083) Theodoraki E.V. … Dedoussis G.V. (BMC Med. Genet. 2010) 3 22 46 64
  3. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. (PMID: 19136375) Peters A. … Wichmann H.E. (Am. J. Respir. Crit. Care Med. 2009) 3 22 46 64
  4. Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms. (PMID: 19750100) Ljungman P. … Peters A. (Environ. Health Perspect. 2009) 3 22 46 64
  5. [Complex analysis of genetic predisposition to ischemic stroke in Russians]. (PMID: 19899640) Parfenov M.G. … Favorova O.O. (Mol. Biol. (Mosk.) 2009) 3 22 46 64

Products for FGB Gene

Sources for FGB Gene

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