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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGB Gene

protein-coding GIFtS: 67
GCID: GC04P155484

fibrinogen beta chain

(Previous names: fibrinogen, B beta polypeptide )

Explore 71 diseases affiliated with
FGB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibrinogen Beta Chain¹ ²
Fibrinogen, B Beta Polypeptide¹ ²

External Ids:	HGNC: 3662¹	Entrez Gene: 2244²	Ensembl: ENSG00000171564⁷	OMIM: 134830⁵	UniProtKB: P02675³

Export aliases for FGB gene to outside databases

Previous GC identifers: GC04P156333 GC04P155872 GC04P155950 GC04P156061 GC04P155841 GC04P155703 GC04P151224

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGB:

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three

pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin

which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin

regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several

cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia,

hypodysfibrinogenemia and thrombotic tendency. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in

platelet aggregation

Gene Wiki entry for FGB (Fibrinogen beta chain)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGB gene promoter:
POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 NF-AT NF-AT4 NF-AT2 NF-AT3 ZIC2/Zic2 Pax-4a NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGB promoter sequence

Search SABiosciences Chromatin IP Primers for FGB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q28

FGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGB gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P155484: view genomic region (about GC identifiers)

Start:	155,484,108 bp from pter	End:	155,493,915 bp from pter
Size:	9,808 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675 (See protein sequence)

Recommended Name: Fibrinogen beta chain precursor

Size: 491 amino acids; 55928 Da

Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2

heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity)

Subcellular location: Secreted

6/31 PDB 3D structures from and Proteopedia for FGB (see all 31):

1FZA (3D)

1FZB (3D)

1FZC (3D)

1FZE (3D)

1FZF (3D)

1FZG (3D)

Secondary accessions: B2R7G3 Q3KPF2

Explore the universe of human proteins at neXtProt for FGB: NX_P02675

Post-translational modifications:

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta

chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft

clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking

between gamma chains (stronger) and between alpha chains (weaker) of different monomers¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02675

FGB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171670.1 NP_005132.2

ENSEMBL proteins:

ENSP00000306099 ENSP00000398719 ENSP00000426757

Reactome Protein details: P02675
Human Recombinant Protein Products for FGB:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005577	fibrinogen complex	IEA	--
GO:0005615	extracellular space	IDA	19996109
GO:0005625	soluble fraction	--	--
GO:0005886	plasma membrane	TAS	--

FGB for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGB for domains About GeneDecksing

5 InterPro domains/families:

IPR012290 Fibrinogen_a/b/g_coil_dom

IPR014715 Fibrinogen_a/b/g_C_2

IPR014716 Fibrinogen_a/b/g_C_1

IPR020837 Fibrinogen_CS

IPR002181 Fibrinogen_a/b/g_C_dom

Graphical View of Domain Structure for InterPro Entry P02675

ProtoNet protein and cluster: P02675

1 Blocks protein family: IPB002181 Fibrinogen

UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675

Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal

domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the

coiled coil structure

Similarity: Contains 1 fibrinogen C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FIBB_HUMAN, P02675

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in

platelet aggregation

Genatlas biochemistry entry for FGB:

fibrinogen,beta polypeptide, (see FG@)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0030674	protein binding, bridging	IEA	--
GO:0043499	eukaryotic cell surface binding	IDA	6777381
GO:0051087	chaperone binding	IPI	19996109

FGB for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Common Pathway

	Common Pathway	1.00			fibrin multimer -> fibrin multimer, crosslinked + NH4+	0.36
	Extrinsic Prothrombin Activation Pathway	0.69

Formation of Fibrin Clot (Clotting Cascade)

	Formation of Fibrin Clot (Clotting Cascade)	1.00			Blood Clotting Cascade	0.36
	Blood Coagulation Signaling Pathways	0.51

Cell adhesion_Integrin inside-out signaling

Cell adhesion_Integrin inside-out signaling

1.00

Cell adhesion Integrin inside-out signaling

0.99

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for FGB

	Cell adhesion Integrin inside-out signaling
	Metalloproteases in connective tissue degradation
	Cell adhesion Plasmin signaling

1 R&D Systems Pathway for FGB

Blood Coagulation Signaling Pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGB

	Extrinsic Prothrombin Activation Pathway
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

2 GeneGo (Thomson Reuters) Pathways for FGB

	Cell adhesion Integrin inside-out signaling
	Cell adhesion Plasmin signaling

2 BioSystems Pathways for FGB

	Blood Clotting Cascade
	Complement and Coagulation Cascades

5/13 Reactome Pathways for FGB (see all 13)

	Hemostasis
	Integrin cell surface interactions
	Response to elevated platelet cytosolic Ca2+
	p130Cas linkage to MAPK signaling for integrins
	Common Pathway

1 PharmGKB Pathway for FGB

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for FGB):

Complement and coagulation cascades

FGB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FGB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/43 Interacting proteins for FGB (P02675^{2, 3} ENSP00000306099⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271146 I2D: score=2
SMN2	Q16637²^,³	MINT-8271146 I2D: score=2
AIMP2	Q13155²^,³	MINT-8258882 I2D: score=2
ANXA7	P20073²^,³	MINT-8248362 I2D: score=2
CDKN1A	P38936²^,³	MINT-8251893 I2D: score=2

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0007165	signal transduction	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--
GO:0051258	protein polymerization	IEA	--

FGB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FGB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGB

1 DrugBank Compound for FGB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sucralfate	--	54182-58-0	target	antagonist	6892775

9 Novoseek chemical compound relationships for FGB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	88.7	91	9753458 (2), 10712387 (2), 18331453 (2), 12871501 (2) (see all 60)
batroxobin	78.3	3	9397156 (1), 12805063 (1), 1799661 (1)
hirudin	56.6	6	11142354 (2), 9868910 (1), 7923685 (1)
rsai	55	1	15795544 (1)
serine	32.1	2	11910192 (1), 17982312 (1)
heparin	26.5	1	8822924 (1)
calcium	2.39	5	15572240 (2), 14764520 (1), 8331664 (1)
nacl	0	1	8605191 (1)
tyrosine	0	2	9311149 (1), 9753458 (1)

Search CenterWatch for drugs/clinical trials and news about FGB / FIBB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGB gene (2 alternative transcripts):

NM_001184741.1 NM_005141.4

Unigene Cluster for FGB:

Fibrinogen beta chain

Hs.300774 [show with all ESTs]

Unigene Representative Sequence: NM_005141

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302068(uc003ioa.4 uc010ipv.3) ENST00000498375(uc010ipu.1)

ENST00000497097 ENST00000425838 ENST00000509493 ENST00000502545 ENST00000473984

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		hsa-miR-148b* hsa-miR-137 hsa-miR-25 hsa-miR-3150a-3p hsa-miR-3119 hsa-miR-3909 hsa-miR-92b hsa-miR-299-5p

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Additional cDNA sequence:

AK303788.1 AK309592.1 AK312972.1 BC007030.1 BC036007.1 BC070245.1 BC106760.2 BC107766.1

J00129.1 J00133.1

24/47 DOTS entries (see all 47):

DT.454371 DT.95378916 DT.100890715 DT.100890713 DT.121235436 DT.91770011 DT.100890732 DT.121235387

DT.91848881 DT.91740978 DT.121235433 DT.91770029 DT.220241 DT.91755645 DT.91770005 DT.91770002

DT.95165598 DT.100890697 DT.100890754 DT.100890748 DT.100045220 DT.100890696 DT.100890699 DT.100890723

24/950 AceView cDNA sequences (see all 950):

CR595998 AA343616 AV682437 CB153898 AA345821 CR622383 CR605964 AA343547

CB164467 CR611717 CR625311 CR618377 CR622096 CR602828 W77736 BX462919

BC070245 BX423795 CR609143 BX427237 BX405842 CR625535 BX423761 CR604009

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGGAAAGGA

About this image

FGB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Posterior foregut-like cells (A scalable, suspensi...)

DKK1-induced cells (Derivation of cardio...)

Cardiomyocyte-like progenitor cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FGB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGB

SOURCE GeneReport for Unigene cluster: Hs.300774

SABiosciences Expression via Pathway-Focused PCR Arrays including FGB:

Nephrotoxicity in human mouse rat

Atherosclerosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FGB gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGB¹	fibrinogen beta chain	69.97(n) 66.88(a)		373926 NM_001167683.1 NP_001161155.1
lizard (Anolis carolinensis)	Reptilia	FGB⁶	--	64(a)	1 ↔ 1	5(130269691-130279465)
African clawed frog (Xenopus laevis)	Amphibia	LOC397825²	B fibrinopeptide	79.4(n)		BC054326.1
zebrafish (Danio rerio)	Actinopterygii	fgb¹	fibrinogen, B beta polypeptide	59(n) 56.75(a)		337315 NM_212774.1 NP_997939.1

ENSEMBL Gene Tree for FGB (if available)
TreeFam Gene Tree for FGB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGB gene

FGL2² ANGPT4² FGA² FGG² ANGPTL6² ANGPTL2² ANGPTL4² ANGPT1²

ANGPTL3² ANGPTL1² ANGPTL7² ANGPT2² FGL1²

15 SIMAP similar genes for FGB using alignment to 6 protein entries: FIBB_HUMAN (see all proteins):

FGA FGL1 FGG DKFZp779N0926 LFIRE1 FCN3

ANGPTL2 MFAP4 ANGPTL7 ANGPTL6 FCN1 ANGPT1

FCN2 ANGPTL4 TNC

FGB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121909625^1,2	C	pathogenic	151227680(+)	`GTCATC/TGACCC`	4	R *	stg¹		1		EU	1321
rs4220^1,2	C,F,A,H	other	151232454(+)	`AATGAG/AGAAGA`	4	/K /R	mis¹ ese³		38		MN NS EA NA WA EU	14345
rs77327265^1,2		--	151222982(+)	`TACCCG/ATCACT`	2	--	us2k¹		1		NA	120
rs2227385^1,2	C,F,H	--	151223007(+)	`GAACTA/GTTTGT`	2	--	us2k¹		10		NS EA NA CSA WA	612
rs36203766^1,2	C	--	151223027(+)	`GTTAAA/GTCTGT`	2	--	us2k¹		0	--	--	--	--
rs36203403^1,2	C	--	151223307(+)	`AGATAA/GTTCTT`	2	--	us2k¹		0	--	--	--	--
rs2227387^1,2	C,F,H	--	151223642(+)	`CTATGC/TTACCA`	2	--	us2k¹		7		NS EA WA	614
rs2227388^1,2	C,F	--	151223716(+)	`GGAGAA/GGAAAG`	2	--	us2k¹ trp³		7		NS NA WA CSA	211
rs2227392^1,2	C,H	--	151224409(+)	`GGCCCC/TTTTTG`	2	--	us2k¹		11		NS EA MN	884
rs113961753^1,2	C	--	151224858(+)	`TCAGTA/G/TAAGTC`	4	--	ut5¹		1		CSA	1

HapMap Linkage Disequilibrium report for FGB (155484108 - 155493915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FGB: --
Human Gene Mutation Database (HGMD): FGB

Locus Specific Mutation Databases (LSDB): FGB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGB for disorders           About GeneDecksing

OMIM gene information: 134830
OMIM disorders: 202400
UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675

Defects in FGB are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive

disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels

of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different

clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a

predisposition for thrombosis with or without bleeding

20/71 diseases for FGB (see all 71): About MalaCards

afibrinogenemia dysfibrinogenemia carotid intimal medial thickness thrombophilia, dysfibrinogenemic

dysfibrinogenemia, beta type deep vein thrombosis age related macular degeneration congenital afibrinogenemia

retinal vein occlusion blood clots pulmonary embolism hypofibrinogenemia

type 2 diabetes mellitus myocardial infarction thrombophilia macular degeneration

amyotrophic lateral sclerosis cerebrovascular accident venous thrombosis ischemic heart disease

1 disease from the University of Copenhagen DISEASES database for FGB:

Congenital afibrinogenemia

7 Novoseek disease relationships for FGB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
congenital afibrinogenemia	95	2	12511408 (1), 10891444 (1)
afibrinogenemia	93.7	9	18853456 (2), 12511408 (1), 19551918 (1), 16999847 (1) (see all 6)
hypofibrinogenemia	79.2	1	18676163 (1)
coagulopathy	41.8	2	18676163 (1), 19551918 (1)
myocardial infarction	22.8	2	16525568 (1), 18278190 (1)
venous thrombosis	10	1	12893031 (1)
pulmonary embolism	0	2	12893031 (2)

Genetic Association Database (GAD): FGB
Human Genome Epidemiology (HuGE) Navigator: FGB (196 documents)

Export disorders for FGB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FGB gene, integrated from 9 sources (see all 435):
(articles sorted by number of sources associating them with FGB)

Utopia: connect your pdf to the dynamic
world of online information

Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. (PubMed id 15983960)^{1, 4, 9} Liu Y....Coresh J. (2005)
A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine. (PubMed id 2018836)^{1, 2, 9} Yoshida N.... Shirakawa S. (1991)
Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. (PubMed id 15735812)^{1, 4, 9} Mannila M.N....Silveira A. (2005)
gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians. (PubMed id 15795540)^{1, 4, 9} Ivaskevicius V....Oldenburg J. (2005)
Relationship among urinary albumin excretion rate, lipoprotein lipase PvuII polymorphism and plasma fibrinogen in type 2 diabetic patients. (PubMed id 15857159)^{1, 4} Javorsky M....Tkac I. (2006)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (2006)
A role of TNF-alpha gene variant on juvenile ischemic stroke: a case-control study. (PubMed id 16324093)^{1, 4} Rubattu S....Rasura M. (2005)
Coagulation gene polymorphisms as risk factors for myocardial infarction in young Indian Asians. (PubMed id 16049588)^{1, 4} Pegoraro R.J....Rom L. (2005)
Role of thrombophilic gene polymorphisms in branch retinal vein occlusion. (PubMed id 16157382)^{1, 4} Weger M....Haas A. (2005)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2244	HGNC: 3662	AceView: FGB	Ensembl:ENSG00000171564	euGenes: HUgn2244
ECgene: FGB	Kegg: 2244	H-InvDB: FGB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FGB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGB	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FGB
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FGB
Wikipedia	http://en.wikipedia.org/wiki/Fibrinogen
SeattleSNPs	http://pga.gs.washington.edu/data/fgb/

Intellectual Property for FGB gene
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About This Section

Patent Information for FGB gene:
Search GeneIP for patents involving FGB

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

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