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Aliases for FGB Gene

Aliases for FGB Gene

  • Fibrinogen Beta Chain 2 3
  • Fibrinogen, B Beta Polypeptide 2 3
  • Epididymis Secretory Sperm Binding Protein Li 78p 3
  • HEL-S-78p 3

External Ids for FGB Gene

Previous GeneCards Identifiers for FGB Gene

  • GC04P156333
  • GC04P155872
  • GC04P155950
  • GC04P156061
  • GC04P155841
  • GC04P155703
  • GC04P155484
  • GC04P151224

Summaries for FGB Gene

Entrez Gene Summary for FGB Gene

  • The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for FGB Gene

FGB (Fibrinogen Beta Chain) is a Protein Coding gene. Diseases associated with FGB include dysfibrinogenemia, congenital and afibrinogenemia, congenital. Among its related pathways are Signaling by GPCR and Hemostasis. GO annotations related to this gene include receptor binding and chaperone binding. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for FGB Gene

  • Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGB Gene

Genomics for FGB Gene

Genomic Location for FGB Gene

Start:
154,562,956 bp from pter
End:
154,572,763 bp from pter
Size:
9,808 bases
Orientation:
Plus strand

Genomic View for FGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGB Gene

Proteins for FGB Gene

  • Protein details for FGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02675-FIBB_HUMAN
    Recommended name:
    Fibrinogen beta chain
    Protein Accession:
    P02675
    Secondary Accessions:
    • A0JLR9
    • B2R7G3
    • Q32Q65
    • Q3KPF2

    Protein attributes for FGB Gene

    Size:
    491 amino acids
    Molecular mass:
    55928 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).
    SequenceCaution:
    • Sequence=AAH07030.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGB Gene

neXtProt entry for FGB Gene

Proteomics data for FGB Gene at MOPED

Post-translational modifications for FGB Gene

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Glycosylation at Asn394
  • Modification sites at PhosphoSitePlus

Other Protein References for FGB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGB Gene

Domains for FGB Gene

Gene Families for FGB Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • FIBC :Fibrinogen C domain containing

Graphical View of Domain Structure for InterPro Entry

P02675

UniProtKB/Swiss-Prot:

FIBB_HUMAN :
  • P02675
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGB: view

Function for FGB Gene

Molecular function for FGB Gene

GENATLAS Biochemistry:
fibrinogen,beta polypeptide, (see FG@)
UniProtKB/Swiss-Prot Function:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Ontology (GO) - Molecular Function for FGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 contributes_to receptor binding IDA 10903502
GO:0005198 structural molecule activity IDA 8910396
GO:0005515 protein binding IPI 12706644
GO:0030674 protein binding, bridging IEA --
GO:0050839 contributes_to cell adhesion molecule binding IDA 9182580
genes like me logo Genes that share ontologies with FGB: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGB Gene

Localization for FGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGB Gene COMPARTMENTS Subcellular localization image for FGB gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex IDA 8910396
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FGB: view

Pathways for FGB Gene

genes like me logo Genes that share pathways with FGB: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007160 cell-matrix adhesion IDA 10903502
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with FGB: view

Compounds for FGB Gene

(1) Drugbank Compounds for FGB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sucralfate
54182-58-0 target antagonist

(9) Novoseek inferred chemical compound relationships for FGB Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 88.7 68
batroxobin 78.3 3
hirudin 56.6 4
rsai 55 1
serine 32.1 2
genes like me logo Genes that share compounds with FGB: view

Transcripts for FGB Gene

Unigene Clusters for FGB Gene

Fibrinogen beta chain:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGB Gene

No ASD Table

Relevant External Links for FGB Gene

GeneLoc Exon Structure for
FGB
ECgene alternative splicing isoforms for
FGB

Expression for FGB Gene

mRNA expression in normal human tissues for FGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGB Gene

This gene is overexpressed in Liver (52.7).

Protein differential expression in normal tissues for FGB Gene

This gene is overexpressed in Synovial fluid (10.1) and Lavage (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FGB Gene

SOURCE GeneReport for Unigene cluster for FGB Gene Hs.300774

genes like me logo Genes that share expressions with FGB: view

Expression partners for FGB Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FGB Gene

Orthologs for FGB Gene

This gene was present in the common ancestor of animals.

Orthologs for FGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGB 35
  • 85.11 (n)
  • 82.17 (a)
FGB 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGB 35
  • 87.64 (n)
  • 85.25 (a)
FGB 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgb 35
  • 83.19 (n)
  • 84.62 (a)
Fgb 16
Fgb 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGB 35
  • 99.39 (n)
  • 99.19 (a)
BETA-FIBRINOGEN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgb 35
  • 80.92 (n)
  • 82.18 (a)
oppossum
(Monodelphis domestica)
Mammalia FGB 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGB 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGB 35
  • 69.97 (n)
  • 66.88 (a)
FGB 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGB 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgb 35
  • 67.55 (n)
  • 66.3 (a)
Str.8476 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397825 35
zebrafish
(Danio rerio)
Actinopterygii fgb 35
  • 59.72 (n)
  • 57.62 (a)
fgb 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10534 35
fruit fly
(Drosophila melanogaster)
Insecta CG41520 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for FGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGB Gene

ENSEMBL:
Gene Tree for FGB (if available)
TreeFam:
Gene Tree for FGB (if available)

Paralogs for FGB Gene

genes like me logo Genes that share paralogs with FGB: view

Variants for FGB Gene

Sequence variations from dbSNP and Humsavar for FGB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4220 other, - 154,570,607(+) AATGA(A/G)GAAGA missense, reference
rs4681 -- 154,569,680(+) AAATA(C/T)AGAGG reference, synonymous-codon
rs6053 - 154,563,022(+) ACATG(A/G)AAAGG reference, missense
rs6054 - 154,568,456(+) CAAAC(C/T)GTATA reference, missense
rs6055 -- 154,566,500(+) TTGTG(C/T)CCTAC intron-variant, synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FGB Gene

Variant ID Type Subtype PubMed ID
dgv5783n71 CNV Loss 21882294
nsv880875 CNV Gain 21882294
dgv5784n71 CNV Gain 21882294

Relevant External Links for FGB Gene

HapMap Linkage Disequilibrium report
FGB
Human Gene Mutation Database (HGMD)
FGB
Locus Specific Mutation Databases (LSDB)
FGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGB Gene

Disorders for FGB Gene

(1) OMIM Diseases for FGB Gene (134830)

UniProtKB/Swiss-Prot

FIBB_HUMAN
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:10666208, ECO:0000269 PubMed:11468164, ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:1634610}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FGB Gene

(7) Novoseek inferred disease relationships for FGB Gene

Disease -log(P) Hits PubMed IDs
congenital afibrinogenemia 95 2
afibrinogenemia 93.7 7
hypofibrinogenemia 79.2 1
coagulopathy 41.8 2
myocardial infarction 22.8 2

Relevant External Links for FGB

Genetic Association Database (GAD)
FGB
Human Genome Epidemiology (HuGE) Navigator
FGB
genes like me logo Genes that share disorders with FGB: view

No data available for Genatlas for FGB Gene

Publications for FGB Gene

  1. A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine. (PMID: 2018836) Yoshida N. … Shirakawa S. (Blood 1991) 3 4 23
  2. gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians. (PMID: 15795540) Ivaskevicius V. … Oldenburg J. (Blood Coagul. Fibrinolysis 2005) 3 23 48
  3. Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. (PMID: 15983960) Liu Y. … Coresh J. (Am. J. Kidney Dis. 2005) 3 23 48
  4. Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction. (PMID: 16525568) Mannila M.N. … Silveira A. (Thromb. Haemost. 2006) 3 23 48
  5. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. (PMID: 17469143) Gong R. … Li L. (Arthritis Rheum. 2007) 3 23 48

Products for FGB Gene

  • Addgene plasmids for FGB

Sources for FGB Gene

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