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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGB Gene

protein-coding   GIFtS: 69
GCID: GC04P155484

Fibrinogen Beta Chain

(Previous names: fibrinogen, B beta polypeptide)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibrinogen Beta Chain1 2
Fibrinogen, B Beta Polypeptide1 2

External Ids:    HGNC: 36621   Entrez Gene: 22442   Ensembl: ENSG000001715647   OMIM: 1348305   UniProtKB: P026753   

Export aliases for FGB gene to outside databases

Previous GC identifers: GC04P156333 GC04P155872 GC04P155950 GC04P156061 GC04P155841 GC04P155703 GC04P151224


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGB Gene:
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of
three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to
form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of
fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities,
and are mitogens for several cell types. Mutations in this gene lead to several disorders, including
afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGB Gene: 
FGB (fibrinogen beta chain) is a protein-coding gene. Diseases associated with FGB include afibrinogenemia, and fgb-related congenital afibrinogenemia, and among its related super-pathways are Blood Coagulation Signaling Pathways and Complement and Coagulation Cascades. GO annotations related to this gene include chaperone binding and receptor binding. An important paralog of this gene is TNR.

UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
in platelet aggregation

Gene Wiki entry for FGB (Fibrinogen beta chain) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGB gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   NF-AT   NF-AT4   NF-AT2   NF-AT3   ZIC2/Zic2   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGB promoter sequence
   Search SABiosciences Chromatin IP Primers for FGB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q28

FGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P155484:  view genomic region     (about GC identifiers)

Start:
155,484,108 bp from pter      End:
155,493,915 bp from pter
Size:
9,808 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675 (See protein sequence)
Recommended Name: Fibrinogen beta chain precursor  
Size: 491 amino acids; 55928 Da
Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2
heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity)
Subcellular location: Secreted
6/31 PDB 3D structures from and Proteopedia for FGB (see all 31):
1FZA (3D)        1FZB (3D)        1FZC (3D)        1FZE (3D)        1FZF (3D)        1FZG (3D)    
Secondary accessions: B2R7G3 Q3KPF2

Explore the universe of human proteins at neXtProt for FGB: NX_P02675

Explore proteomics data for FGB at MOPED 

Post-translational modifications:

  • UniProtKB: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and
    beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
    The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine
    cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02675

  • FGB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171670.1  NP_005132.2  

    ENSEMBL proteins: 
     ENSP00000306099   ENSP00000398719   ENSP00000426757  
    Reactome Protein details: P02675
    Human Recombinant Protein Products for FGB: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IEA--
    GO:0005615extracellular space IDA19996109
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--

    FGB for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR012290 Fibrinogen_a/b/g_coil_dom
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry P02675

    ProtoNet protein and cluster: P02675

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675
    Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal
    domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to
    the coiled coil structure
    Similarity: Contains 1 fibrinogen C-terminal domain


    FGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIBB_HUMAN, P02675
    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
    in platelet aggregation

         Genatlas biochemistry entry for FGB:
    fibrinogen,beta polypeptide, (see FG@)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0030674protein binding, bridging IEA--
    GO:0051087chaperone binding IPI19996109
         
    FGB for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidFGB 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGB About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Clotting Cascade0.42
    Blood Coagulation Signaling Pathways0.51
    2Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    3Common Pathway
    Common Pathway0.69
    Extrinsic Prothrombin Activation Pathway0.69
    4Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    5GRB2:SOS provides linkage to MAPK signaling for Intergrins
    GRB2:SOS provides linkage to MAPK signaling for Intergrins 0.76
    p130Cas linkage to MAPK signaling for integrins0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for FGB
        Cell adhesion Integrin inside-out signaling
    Metalloproteases in connective tissue degradation
    Cell adhesion Plasmin signaling

    1 R&D Systems Pathway for FGB
        Blood Coagulation Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGB
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 GeneGo (Thomson Reuters) Pathways for FGB
        Cell adhesion Integrin inside-out signaling
    Cell adhesion Plasmin signaling

    2 BioSystems Pathways for FGB
        Blood Clotting Cascade
    Complement and Coagulation Cascades


    5/12        Reactome Pathways for FGB (see all 12)
        Hemostasis
    Integrin cell surface interactions
    Response to elevated platelet cytosolic Ca2+
    p130Cas linkage to MAPK signaling for integrins
    Common Pathway

    1 PharmGKB Pathway for FGB
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for FGB):
        Complement and coagulation cascades


    FGB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for FGB (P026752, 3 ENSP000003060994) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271146 I2D: score=2 
    SMN2Q166372, 3MINT-8271146 I2D: score=2 
    AIMP2Q131552, 3MINT-8258882 I2D: score=2 
    ANXA7P200732, 3MINT-8248362 I2D: score=2 
    CDKN1AP389362, 3MINT-8251893 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0051258protein polymerization IEA--

    FGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGB (FIBB)

    1 DrugBank Compound for FGB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sucralfate-- 54182-58-0targetantagonist6892775

    9 Novoseek inferred chemical compound relationships for FGB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 88.7 91 9753458 (2), 10712387 (2), 18331453 (2), 12871501 (2) (see all 60)
    batroxobin 78.3 3 9397156 (1), 12805063 (1), 1799661 (1)
    hirudin 56.6 6 11142354 (2), 9868910 (1), 7923685 (1)
    rsai 55 1 15795544 (1)
    serine 32.1 2 11910192 (1), 17982312 (1)
    heparin 26.5 1 8822924 (1)
    calcium 2.39 5 15572240 (2), 14764520 (1), 8331664 (1)
    nacl 0 1 8605191 (1)
    tyrosine 0 2 9311149 (1), 9753458 (1)

    Search CenterWatch for drugs/clinical trials and news about FGB / FIBB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGB gene (2 alternative transcripts): 
    NM_001184741.1  NM_005141.4  

    Unigene Cluster for FGB:

    Fibrinogen beta chain
    Hs.300774  [show with all ESTs]
    Unigene Representative Sequence: NM_005141
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302068(uc003ioa.4 uc010ipv.3) ENST00000498375(uc010ipu.1)
    ENST00000497097 ENST00000425838 ENST00000509493 ENST00000502545 ENST00000473984


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    Additional mRNA sequence: 

    AK303788.1 AK309592.1 AK312972.1 BC007030.1 BC036007.1 BC070245.1 BC106760.2 BC107766.1 
    J00129.1 J00133.1 

    24/47 DOTS entries (see all 47):

    DT.454371  DT.95378916  DT.100890715  DT.100890713  DT.121235436  DT.91770011  DT.100890732  DT.121235387 
    DT.91848881  DT.91740978  DT.121235433  DT.91770029  DT.220241  DT.91755645  DT.91770005  DT.91770002 
    DT.95165598  DT.100890697  DT.100890754  DT.100890748  DT.100045220  DT.100890696  DT.100890699  DT.100890723 

    24/950 AceView cDNA sequences (see all 950):

    CR617919 CB120343 CR621583 BX497231 CR597353 CR626502 CR604313 CR603045 
    CR617356 CR592803 AA345208 BX340587 CR597369 AL531454 BI834698 CR623131 
    CR625744 CR607409 CR593807 CB114918 CR605515 CR598606 BC007030 AL531306 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGB expression in normal human tissues (normalized intensities)      FGB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGAAAGGA
    FGB Expression
    About this image


    FGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
             colon ; endothelial cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Human Hepatocyte (HH)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; glandular cells   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...

    See FGB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGB

    SOURCE GeneReport for Unigene cluster: Hs.300774
        SABiosciences Expression via Pathway-Focused PCR Arrays including FGB: 
              Nephrotoxicity in human mouse rat
              Atherosclerosis in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGB gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgb1 , 5 fibrinogen beta chain1, 5 83.09(n)1
    84.7(a)1
      3 (36.98 cM)5
    1101351  NM_181849.21  NP_862897.11 
     830423035 
    chicken
    (Gallus gallus)
    Aves FGB1 fibrinogen beta chain 69.97(n)
    66.88(a)
      373926  NM_001167683.1  NP_001161155.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGB6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    5(130267188-130279641)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978252 B fibrinopeptide 79.4(n)    BC054326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgb1 fibrinogen, B beta polypeptide 59(n)
    56.75(a)
      337315  NM_212774.1  NP_997939.1 


    ENSEMBL Gene Tree for FGB (if available)
    TreeFam Gene Tree for FGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGB gene
    TNR2  FGG2  FGA2  ANGPTL42  ANGPTL32  TNXB2  TNN2  ANGPTL52  
    TNC2  FGL12  FN12  
    13 SIMAP similar genes for FGB using alignment to 6 protein entries:     FIBB_HUMAN (see all proteins):
    FGA    FGL1    FGG    DKFZp779N0926    LFIRE1    FCN3
    ANGPTL2    MFAP4    ANGPTL7    ANGPTL6    FCN1    ANGPT1
    FCN2

    FGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in FGB are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0169084
    Congenital afibrinogenemia (CAFBN)4--see VAR_0169082 R C mis40--------
    VAR_0169104
    Congenital afibrinogenemia (CAFBN)4--see VAR_0169102 G D mis40--------
    VAR_0169094
    Congenital afibrinogenemia (CAFBN)4--see VAR_0169092 L R mis40--------
    rs1219096251,2
    Cpathogenic1155279512(+) GTCATC/TGACCC 4 R * stg11Minor allele frequency- T:0.00EU 1321
    rs1219096161,2
    Cother1155279503(+) GTGCCC/TGTGGT 4 R C mis10--------
    rs42201,2,4
    C,F,A,Hother1155284287(+) AATGAG/AGAAGA 4 /K /R mis1 ese338Minor allele frequency- A:0.16MN NS EA NA WA EU 14345
    VAR_0024074
    ----see VAR_0024072 A T mis40--------
    VAR_0024034
    ----see VAR_0024032 R C mis40--------
    VAR_0024044
    ----see VAR_0024042 G R mis40--------
    VAR_0024054
    ----see VAR_0024052 R C mis40--------

    HapMap Linkage Disequilibrium report for FGB (155484108 - 155493915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGB:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5783n71CNV Loss21882294
    nsv880875CNV Gain21882294
    dgv5784n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): FGB

    Locus Specific Mutation Databases (LSDB): FGB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FGB
    DNA2.0 Custom Variant and Variant Library Synthesis for FGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134830   
    OMIM disorders: 202400  
    UniProtKB/Swiss-Prot: FIBB_HUMAN, P02675
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by
    bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet
    fibrinogen. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with
    congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent,
    some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding

  • 20/60 diseases for FGB (see all 60):    About MalaCards
    afibrinogenemia    fgb-related congenital afibrinogenemia    congenital afibrinogenemia    chronic thromboembolic pulmonary hypertension
    dysfibrinogenemia    hepatitis e    blood clots    pulmonary embolism
    peripheral vascular disease    deep vein thrombosis    retinal vein occlusion    portal hypertension
    thrombophilia    cerebral palsy    thrombosis    cerebral infarction
    familial hypercholesterolemia    thromboembolism    vascular disease    venous thromboembolism

    1 disease from the University of Copenhagen DISEASES database for FGB:
    Congenital afibrinogenemia

    FGB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for FGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital afibrinogenemia 95 2 12511408 (1), 10891444 (1)
    afibrinogenemia 93.7 9 18853456 (2), 12511408 (1), 19551918 (1), 16999847 (1) (see all 6)
    hypofibrinogenemia 79.2 1 18676163 (1)
    coagulopathy 41.8 2 18676163 (1), 19551918 (1)
    myocardial infarction 22.8 2 16525568 (1), 18278190 (1)
    venous thrombosis 10 1 12893031 (1)
    pulmonary embolism 0 2 12893031 (2)

    Genetic Association Database (GAD): FGB
    Human Genome Epidemiology (HuGE) Navigator: FGB (196 documents)

    Export disorders for FGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGB gene, integrated from 9 sources (see all 453):
    (articles sorted by number of sources associating them with FGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibrinogen beta variants confer protection against co ronary artery disease in a Greek case-control study. (PubMed id 20167083)1, 4, 9 Theodoraki E.V....Dedoussis G.V. (2010)
    2. Fibrinogen gene variation and ischemic stroke. (PubMed id 18331453)1, 4, 9 Jood K....Jern C. (2008)
    3. Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. (PubMed id 15983960)1, 4, 9 Liu Y....Coresh J. (2005)
    4. Modification of the interleukin-6 response to air pol lution by interleukin-6 and fibrinogen polymorphisms. (PubMed id 19750100)1, 4, 9 Ljungman P....Peters A. (2009)
    5. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. (PubMed id 19136375)1, 4, 9 Peters A....Wichmann H.E. (2009)
    6. [Complex analysis of genetic predisposition to ischem ic stroke in Russians] (PubMed id 19899640)1, 4, 9 Parfenov M.G....Favorova O.O. (2009)
    7. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. (PubMed id 17469143)1, 4, 9 Gong R....Li L. (2007)
    8. A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine. (PubMed id 2018836)1, 2, 9 Yoshida N.... Shirakawa S. (1991)
    9. Interaction between fibrinogen and IL-6 genetic varia nts and associations with cardiovascular disease risk in the Cardiovascular Hea lth Study. (PubMed id 20059469)1, 4, 9 Carty C.L....Reiner A.P. (2010)
    10. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PubMed id 18278190)1, 4, 9 Carty C.L....Reiner A.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2244 HGNC: 3662 AceView: FGB Ensembl:ENSG00000171564 euGenes: HUgn2244
    ECgene: FGB Kegg: 2244 H-InvDB: FGB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGB Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FGB
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FGB
    Wikipedia http://en.wikipedia.org/wiki/Fibrinogen
    SeattleSNPshttp://pga.gs.washington.edu/data/fgb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGB gene:
    Search GeneIP for patents involving FGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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