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FGA Gene

protein-coding   GIFtS: 68
GCID: GC04M155504

Fibrinogen Alpha Chain

(Previous names: fibrinogen, A alpha polypeptide)
  See FGA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibrinogen Alpha Chain1 2
Fibrinogen, A Alpha Polypeptide1 2
Fib22

External Ids:    HGNC: 36611   Entrez Gene: 22432   Ensembl: ENSG000001715607   OMIM: 1348205   UniProtKB: P026713   

Export aliases for FGA gene to outside databases

Previous GC identifers: GC04M156353 GC04M155892 GC04M155970 GC04M156081 GC04M155826 GC04M155723 GC04M151244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGA Gene:
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of
three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to
form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of
fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities,
and are mitogens for several cell types. Mutations in this gene lead to several disorders, including
dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two
isoforms which vary in the carboxy-terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGA Gene:
FGA (fibrinogen alpha chain) is a protein-coding gene. Diseases associated with FGA include amyloidosis, hereditary renal, and dysfibrinogenemia, alpha type, causing recurrent thrombosis. GO annotations related to this gene include protein binding, bridging and receptor binding. An important paralog of this gene is TNXB.

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
in platelet aggregation

Gene Wiki entry for FGA (Fibrinogen alpha chain) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGA gene promoter:
         ISGF-3   Tal-1   Pbx1a   FOXO3   E47   Evi-1   FOXO3b   STAT3   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGA promoter sequence
   Search Chromatin IP Primers for FGA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q28

FGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M155504:  view genomic region     (about GC identifiers)

Start:
155,504,278 bp from pter      End:
155,511,918 bp from pter
Size:
7,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671 (See protein sequence)
Recommended Name: Fibrinogen alpha chain precursor  
Size: 866 amino acids; 94973 Da
Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2
heterotrimers are in head to head conformation with the N-termini in a small central domain
Selected PDB 3D structures from and Proteopedia for FGA (see all 37):
1BBR (3D)        1DM4 (3D)        1FZA (3D)        1FZB (3D)        1FZC (3D)        1FZD (3D)    
Secondary accessions: A8K3E4 D3DP14 D3DP15 Q4QQH7 Q9BX62 Q9UCH2
Alternative splicing: 2 isoforms:  P02671-1   P02671-2   (Ref.3 (AAK31372) sequence is in conflict in positions: 640:PSLSP->LPCPPRLS)

Explore the universe of human proteins at neXtProt for FGA: NX_P02671

Explore proteomics data for FGA at MOPED

Post-translational modifications: 

  • The alpha chain is not glycosylated1
  • Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming
    fibronectin-fibrinogen heteropolymers1
  • About one-third of the alpha chains in the molecules in blood were found to be phosphorylated1
  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and
    beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
    The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine
    cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers1
  • Phosphorylation sites are present in the extracellular medium1
  • Glycosylation2 at Thr107, Thr252, Thr283, Thr320, Ser351, Ser453, Thr525, Ser562, Ser586, Thr616,
                                 Asn686
  • Modification sites at PhosphoSitePlus

  • See FGA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000499.1  NP_068657.1  

    ENSEMBL proteins: 
     ENSP00000306361   ENSP00000385981  
    Reactome Protein details: P02671

    FGA Human Recombinant Protein Products:

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    Novus Biologicals FGA Protein
    Novus Biologicals FGA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FGA 

     
    antibodies-online proteins for FGA (16 products) 

     
    antibodies-online peptides for FGA

    FGA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FGA
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    Abcam antibodies for FGA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FGA
    antibodies-online antibodies for FGA (64 products) 

    FGA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for FGA 
    antibodies-online kits for FGA (31 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    FIBC: Fibrinogen C domain containing

    Selected InterPro protein domains (see all 6):
     IPR012290 Fibrinogen_a/b/g_coil_dom
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR021996 Fibrinogen_aC
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS

    Graphical View of Domain Structure for InterPro Entry P02671

    ProtoNet protein and cluster: P02671

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
    Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal
    domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to
    the coiled coil structure
    Similarity: Contains 1 fibrinogen C-terminal domain


    Find genes that share domains with FGA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIBA_HUMAN, P02671
    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
    in platelet aggregation

         Genatlas biochemistry entry for FGA:
    fibrinogen,alpha polypeptide,63kDa (see FG@)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI10954706
    GO:0030674protein binding, bridging IEA--
         
    Find genes that share ontologies with FGA           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fga):
     cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with FGA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fgatm1Jld for FGA

       genOway: Develop your customized and physiologically relevant rodent model for FGA

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGA:
    hsa-mir-29a-3p (MIRT005531), hsa-mir-29b-3p (MIRT005533), hsa-mir-29c-3p (MIRT005527), hsa-mir-144-3p (MIRT005529), hsa-mir-409-3p (MIRT005518)

    Block miRNA regulation of human, mouse, rat FGA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGA (see all 14):
    hsa-miR-600 hsa-miR-520d-5p hsa-miR-4297 hsa-miR-324-3p hsa-miR-548v hsa-miR-139-5p hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmidFGA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGA

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FGA (NM_000508)
    Sino Biological Human cDNA Clone for FGA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGA

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIBA_HUMAN, P02671: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IEA--
    GO:0005615extracellular space IDA6777381
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--

    Find genes that share ontologies with FGA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGA About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Common Pathway0.00
    Blood Clotting Cascade0.42
    Extrinsic Prothrombin Activation Pathway0.00
    2Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    GRB2-SOS provides linkage to MAPK signaling for Intergrins0.00
    Platelet Aggregation (Plug Formation)0.73
    p130Cas linkage to MAPK signaling for integrins0.00
    3Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38


    Find genes that share SuperPaths with FGA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGA
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 GeneGo (Thomson Reuters) Pathways for FGA
        Cell adhesion Integrin inside-out signaling
    Cell adhesion Plasmin signaling

    1 BioSystems Pathway for FGA
        Blood Clotting Cascade


    Selected Reactome Pathways for FGA (see all 7)
        Amyloids
    Integrin cell surface interactions
    Platelet degranulation
    Integrin alphaIIb beta3 signaling
    p130Cas linkage to MAPK signaling for integrins

    1 PharmGKB Pathway for FGA
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for FGA):
        Complement and coagulation cascades

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGA: 
              Atherosclerosis in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGA (P026712, 3 ENSP000003063614) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62623 MINT-62721 MINT-62797 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62623 MINT-62721 MINT-62797 I2D: score=5 
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with FGA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGA (FIBA)

    6 DrugBank Compounds for FGA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alteplaset-PA (see all 4)105857-23-6target--17963464 19436656 18673235
    Reteplaset- PA (see all 4)133652-38-7target--17963464 19436656 18673235
    Tenecteplaset- PA (see all 4)191588-94-0target--17963464 19436656 18673235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Anistreplaset- PA (see all 4)81669-57-0target--17139284 17016423
    Sucralfate-- 54182-58-0targetantagonist6892775

    Selected Novoseek inferred chemical compound relationships for FGA gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinopeptide a 95.1 55 8459055 (4), 7539015 (4), 10369791 (3), 7646626 (3) (see all 27)
    fibrinogen 91.5 317 9916133 (3), 7903170 (2), 20059469 (2), 12706644 (2) (see all 99)
    heparin 78.1 62 7930274 (3), 7860920 (2), 9801927 (2), 8921778 (2) (see all 45)
    batroxobin 78.1 8 8362369 (2), 9397156 (1), 9268200 (1), 9360849 (1) (see all 6)
    hirudin 77.8 7 9868910 (1), 2380171 (1), 1587268 (1), 8571330 (1) (see all 7)
    ancrod 77.1 8 8461606 (1), 9127941 (1), 10933802 (1), 15572240 (1) (see all 7)
    hirugen 73.8 2 2380171 (1), 1590777 (1)
    nafamostat mesilate 57.8 1 8167888 (1)
    calcium heparin 57.1 1 8607111 (1)
    desirudin 56.3 2 8921778 (2)



    Find genes that share compounds with FGA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGA gene (2 alternative transcripts): 
    NM_000508.3  NM_021871.2  

    Unigene Cluster for FGA:

    Fibrinogen alpha chain
    Hs.351593  [show with all ESTs]
    Unigene Representative Sequence: M58569
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302053(uc003iod.1) ENST00000403106(uc003ioe.1 uc003iof.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGA (see all 14):
    hsa-miR-600 hsa-miR-520d-5p hsa-miR-4297 hsa-miR-324-3p hsa-miR-548v hsa-miR-139-5p hsa-miR-29c hsa-miR-29a
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    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGA
      QuantiTect SYBR Green Assays in human, mouse, rat FGA
      QuantiFast Probe-based Assays in human, mouse, rat FGA

    Additional mRNA sequence: 

    AK290559.1 BC020764.1 BC070246.1 BC098280.1 BC099706.1 BC099720.1 BC101935.1 BC105803.1 
    J00127.1 J00128.1 K02272.1 M26878.1 M58569.1 

    Selected DOTS entries (see all 26):

    DT.453599  DT.100697222  DT.92460971  DT.100760439  DT.92460957  DT.100697218  DT.121267490  DT.95201336 
    DT.95201310  DT.92460950  DT.100697203  DT.100697204  DT.100697197  DT.100697211  DT.100697226  DT.121267502 
    DT.95187527  DT.100645631  DT.100697207  DT.100697217  DT.121267493  DT.91896121  DT.92460958  DT.92460970 

    Selected AceView cDNA sequences (see all 761):

    BX494861 CB156798 AL564682 AL531446 BX494773 CB156783 BX382982 CR608055 
    BX494693 AA344441 CB149007 AA235252 AL531192 BX406773 BC070246 AL531515 
    BX494206 CB122305 BX955862 AL532085 AL564443 CB122971 BX445336 AW182929 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAATGGAT
    FGA Expression
    About this image


    FGA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Hepatocyte-like cells
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
     
     Lung (Respiratory System)
    FGA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351593

    UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
    Tissue specificity: Plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGA: 
              Atherosclerosis in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FGA
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FGA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fga1 , 5 fibrinogen alpha chain1, 5 77.35(n)1
    73.79(a)1
      3 (36.96 cM)5
    141611  NM_001111048.11  NP_001104518.11 
     830261535 
    chicken
    (Gallus gallus)
    Aves FGA1 fibrinogen alpha chain 59.98(n)
    50.9(a)
      396307  NM_001271911.1  NP_001258840.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGA6
    fibrinogen alpha chain
    47(a)
    1 ↔ 1
    5(130255918-130266090)
    African clawed frog
    (Xenopus laevis)
    Amphibia fga-prov2 Fibrinogen, A alpha polypeptide 76.01(n)    BC041754.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb59b032 Danio rerio cDNA clone IMAGE3817673, partial cds 74.58(n)    BC054946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86423   -- 42(a)
    (best of 2)
      44D4   --


    ENSEMBL Gene Tree for FGA (if available)
    TreeFam Gene Tree for FGA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGA gene
    TNXB2  ANGPTL32  TNR2  TNN2  ANGPTL42  ANGPTL52  FN12  TNC2  
    6 SIMAP similar genes for FGA using alignment to 5 protein entries:     FIBA_HUMAN (see all proteins):
    FGB    FGL1    ANGPTL7    FCN3    FCN2    FCN1

    Find genes that share paralogs with FGA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGA (see all 333)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0107324
    Amyloidosis 8 (AMYL8)4--see VAR_0107322 R L mis40--------
    VAR_0107314
    Amyloidosis 8 (AMYL8)4--see VAR_0107312 E V mis40--------
    rs785063431,2
    Cpathogenic1155299392(-) TTCCCA/G/TTGGTA 4 R L mis10--------
    rs60501,2,,4
    C,F,A,Hother1155300119(-) GAAGTA/GCTGGA 4 T A mis1 ese338Minor allele frequency- G:0.30MN NS NA EA CSA WA EU 12205
    rs1144588221,2
    F--155296339(+) TTCCCG/ATTCAT 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1917919391,2
    --155296382(+) CTACAC/TAGTAT 1 -- ds50010--------
    rs1840638611,2
    --155296452(+) TGTGAA/GTGTAA 1 -- ds50010--------
    rs286738711,2
    C,F,H--155296567(+) ATAGCG/ATTTAG 1 -- ds500116Minor allele frequency- A:0.12NS EA NA WA 2332
    rs1400555441,2
    --155296597(+) ATTCCC/TCATAA 1 -- ds50010--------
    rs774731781,2
    C,F--155296752(+) TTGAGG/AGATAA 1 -- ds50011Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for FGA (155504278 - 155511918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FGA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268285CNV Insertion20981092
    nsv881601CNV Loss21882294

    Human Gene Mutation Database (HGMD): FGA
    Locus Specific Mutation Databases (LSDB): FGA

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134820   
    OMIM disorders: 105200  202400  
    UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by
    bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet
    fibrinogen. Note=The disease is caused by mutations affecting the gene represented in this entry. The majority of
    cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of
    fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of
    apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement
    of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial
    hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for FGA (see all 28):    
    About MalaCards
    amyloidosis, hereditary renal    dysfibrinogenemia, alpha type, causing recurrent thrombosis    fga-related congenital afibrinogenemia    dysfibrinogenemia
    dysfibrinogenemia, alpha type, causing bleeding diathesis    fga-related familial visceral amyloidosis    familial renal amyloidosis due to fibrinogen a alpha-chain variant    chronic thromboembolic pulmonary hypertension
    amyloidosis, 3 or more types    afibrinogenemia    amyloidosis, renal    congenital afibrinogenemia
    collagen disease    angina pectoris    hereditary amyloidosis    bernard-soulier syndrome
    amyloidosis    intermittent claudication    coronary stenosis    primary pulmonary hypertension

    2 diseases from the University of Copenhagen DISEASES database for FGA:
    Congenital afibrinogenemia     Schizophrenia

    Find genes that share disorders with FGA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FGA gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital afibrinogenemia 88.3 9 15946522 (2), 19417632 (2), 11460507 (1), 12406899 (1) (see all 6)
    afibrinogenemia 86.3 15 17295221 (2), 17393016 (1), 12406899 (1), 12511408 (1) (see all 10)
    dysfibrinogenemia 84.7 3 12706644 (1), 7485081 (1), 20510102 (1)
    hypofibrinogenemia 71.4 8 8426084 (2), 7489960 (1), 17295221 (1), 18676163 (1)
    thrombosis 68 11 1295502 (1), 8348763 (1), 7554626 (1), 1433937 (1) (see all 10)
    thrombophilia 67 8 8446931 (1), 8003387 (1), 2137945 (1), 8914220 (1) (see all 8)
    disseminated intravascular coagulation 66.7 16 8426084 (5), 11460518 (1), 9308756 (1), 8039760 (1) (see all 7)
    coagulopathy 56.1 8 7563081 (1), 18676163 (1), 19551918 (1), 8426084 (1) (see all 7)
    thromboembolism 48.5 5 8426084 (3)
    bleeding 46.8 10 11342472 (1), 8408654 (1), 8291501 (1), 7485081 (1) (see all 9)

    Genetic Association Database (GAD): FGA
    Human Genome Epidemiology (HuGE) Navigator: FGA (60 documents)

    Export disorders for FGA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGA gene, integrated from 10 sources (see all 794):
    (articles sorted by number of sources associating them with FGA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. (PubMed id 8097946)1, 2, 4 Benson M.D.... Correa R. (Nat. Genet. 1993)
    2. Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia. (PubMed id 8473507)1, 2, 4 Koopman J....Caen J.P. (J. Clin. Invest. 1993)
    3. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PubMed id 18690352)1, 4, 9 Cheung E.Y....Breteler M.M. (Thromb. Haemost. 2008)
    4. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PubMed id 20167083)1, 4, 9 Theodoraki E.V....Dedoussis G.V. (BMC Med. Genet. 2010)
    5. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study. (PubMed id 17264959)1, 4, 9 Kardys I....de Maat M.P. (Thromb. Haemost. 2007)
    6. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PubMed id 20059469)1, 4, 9 Carty C.L....Reiner A.P. (Ann. Hum. Genet. 2010)
    7. Fibrinogen gene variation and ischemic stroke. (PubMed id 18331453)1, 4, 9 Jood K....Jern C. (J. Thromb. Haemost. 2008)
    8. Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms. (PubMed id 19750100)1, 4, 9 Ljungman P....Peters A. (Environ. Health Perspect. 2009)
    9. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PubMed id 18278190)1, 4, 9 Carty C.L....Reiner A.P. (Thromb. Haemost. 2008)
    10. Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. (PubMed id 15735812)1, 4, 9 Mannila M.N....Silveira A. (Thromb. Haemost. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2243 HGNC: 3661 AceView: FGA Ensembl:ENSG00000171560 euGenes: HUgn2243
    ECgene: FGA Kegg: 2243 H-InvDB: FGA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGA Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FGA[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FGA
    Wikipedia http://en.wikipedia.org/wiki/Fibrinogen
    SeattleSNPshttp://pga.gs.washington.edu/data/fga/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGA gene:
    Search GeneIP for patents involving FGA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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