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Aliases for FGA Gene

Aliases for FGA Gene

  • Fibrinogen Alpha Chain 2 3
  • Fibrinogen, A Alpha Polypeptide 2 3
  • Fib2 3

External Ids for FGA Gene

Summaries for FGA Gene

Entrez Gene Summary for FGA Gene

  • The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGA Gene

FGA (Fibrinogen Alpha Chain) is a Protein Coding gene. Diseases associated with FGA include dysfibrinogenemia and fga-related congenital afibrinogenemia. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include receptor binding and protein binding, bridging. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for FGA Gene

  • Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGA Gene

Genomics for FGA Gene

Genomic Location for FGA Gene

Start:
154,583,126 bp from pter
End:
154,590,766 bp from pter
Size:
7,641 bases
Orientation:
Minus strand

Genomic View for FGA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGA Gene

Regulatory Elements for FGA Gene

Proteins for FGA Gene

  • Protein details for FGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02671-FIBA_HUMAN
    Recommended name:
    Fibrinogen alpha chain
    Protein Accession:
    P02671
    Secondary Accessions:
    • A8K3E4
    • D3DP14
    • D3DP15
    • Q4QQH7
    • Q9BX62
    • Q9UCH2

    Protein attributes for FGA Gene

    Size:
    866 amino acids
    Molecular mass:
    94973 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain

    Three dimensional structures from OCA and Proteopedia for FGA Gene

    Alternative splice isoforms for FGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGA Gene

Proteomics data for FGA Gene at MOPED

Post-translational modifications for FGA Gene

  • About one-third of the alpha chains in the molecules in blood were found to be phosphorylated
  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers
  • O-glycosylated.
  • Phosphorylation sites are present in the extracellular medium
  • The alpha chain is normally not N-glycosylated (PubMed:23151259), even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells (PubMed:9689040). It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies (PubMed:16335952 and PubMed:19159218), but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr107, Thr252, Thr283, Thr320, Ser351, Ser453, Thr525, Ser562, Ser586, Thr616, and Asn686

Other Protein References for FGA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGA Gene

Domains for FGA Gene

Gene Families for FGA Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • FIBC :Fibrinogen C domain containing

UniProtKB/Swiss-Prot:

FIBA_HUMAN
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure:
    • P02671
  • Contains 1 fibrinogen C-terminal domain.:
    • P02671
genes like me logo Genes that share domains with FGA: view

Function for FGA Gene

Molecular function for FGA Gene

GENATLAS Biochemistry: fibrinogen,alpha polypeptide,63kDa (see FG@)
UniProtKB/Swiss-Prot Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Gene Ontology (GO) - Molecular Function for FGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 contributes_to receptor binding IDA 10903502
GO:0005198 structural molecule activity IMP 10891444
GO:0005515 protein binding IPI 10954706
GO:0030674 protein binding, bridging IEA --
GO:0050839 contributes_to cell adhesion molecule binding IDA 9182580
genes like me logo Genes that share ontologies with FGA: view
genes like me logo Genes that share phenotypes with FGA: view

Animal Models for FGA Gene

MGI Knock Outs for FGA:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGA Gene

Localization for FGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGA Gene COMPARTMENTS Subcellular localization image for FGA gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex IDA 8910396
GO:0005615 extracellular space IDA 6777381
GO:0005886 plasma membrane TAS --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with FGA: view

Pathways for FGA Gene

genes like me logo Genes that share pathways with FGA: view

Gene Ontology (GO) - Biological Process for FGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007160 cell-matrix adhesion IDA 10903502
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with FGA: view

Compounds for FGA Gene

(6) Drugbank Compounds for FGA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Alteplase
  • t-PA
105857-23-6 target
Anistreplase
  • t- PA
81669-57-0 target
Reteplase
  • t- PA
133652-38-7 target
Sucralfate
54182-58-0 target antagonist

(65) Novoseek inferred chemical compound relationships for FGA Gene

Compound -log(P) Hits PubMed IDs
fibrinopeptide a 95.1 41
fibrinogen 91.5 122
heparin 78.1 52
batroxobin 78.1 7
hirudin 77.8 7
genes like me logo Genes that share compounds with FGA: view

Transcripts for FGA Gene

Unigene Clusters for FGA Gene

Fibrinogen alpha chain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGA Gene

No ASD Table

Relevant External Links for FGA Gene

GeneLoc Exon Structure for
FGA
ECgene alternative splicing isoforms for
FGA

Expression for FGA Gene

mRNA expression in normal human tissues for FGA Gene

mRNA differential expression in normal tissues according to GTEx for FGA Gene

This gene is overexpressed in Liver (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGA Gene

SOURCE GeneReport for Unigene cluster for FGA Gene Hs.351593

mRNA Expression by UniProt/SwissProt for FGA Gene

P02671-FIBA_HUMAN
Tissue specificity: Plasma
genes like me logo Genes that share expressions with FGA: view

Orthologs for FGA Gene

This gene was present in the common ancestor of animals.

Orthologs for FGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGA 36
  • 98.73 (n)
  • 97.11 (a)
FGA 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGA 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGA 36
  • 82.69 (n)
  • 76.73 (a)
FGA 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fga 36
  • 77.35 (n)
  • 73.79 (a)
Fga 16
Fga 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGA 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGA 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fga 36
  • 77.45 (n)
  • 74.07 (a)
chicken
(Gallus gallus)
Aves FGA 36
  • 59.98 (n)
  • 50.9 (a)
FGA 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGA 37
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fga-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fga 36
  • 60.41 (n)
  • 52.59 (a)
Str.8667 36
zebrafish
(Danio rerio)
Actinopterygii fga 36
  • 54.01 (n)
  • 49.3 (a)
fga 37
  • 40 (a)
OneToOne
wufb59b03 36
fruit fly
(Drosophila melanogaster)
Insecta sca 37
  • 16 (a)
OneToMany
CG1791 38
  • 38 (a)
CG8642 38
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for FGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGA Gene

ENSEMBL:
Gene Tree for FGA (if available)
TreeFam:
Gene Tree for FGA (if available)

Paralogs for FGA Gene

Paralogs for FGA Gene

Selected SIMAP similar genes for FGA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FGA: view

Variants for FGA Gene

Sequence variations from dbSNP and Humsavar for FGA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4766 -- 154,585,887(-) CACCC(C/T)GATGA synonymous-codon, reference
rs6050 other, - 154,586,438(-) GAAGT(A/G)CTGGA reference, missense
rs6051 -- 154,586,358(-) AGTAC(C/T)GGAAC reference, synonymous-codon
rs6052 - 154,586,093(-) CTGGT(A/G)AAGAG reference, missense
rs10921 -- 154,586,253(-) GGAAG(A/T)TTTAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FGA Gene

Variant ID Type Subtype PubMed ID
esv268285 CNV Insertion 20981092
nsv881601 CNV Loss 21882294

Relevant External Links for FGA Gene

HapMap Linkage Disequilibrium report
FGA
Human Gene Mutation Database (HGMD)
FGA
Locus Specific Mutation Databases (LSDB)
FGA

Disorders for FGA Gene

(2) OMIM Diseases for FGA Gene (134820)

UniProtKB/Swiss-Prot

FIBA_HUMAN
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. {ECO:0000269 PubMed:8097946}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:16846481, ECO:0000269 PubMed:8473507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FGA Gene

(82) Novoseek inferred disease relationships for FGA Gene

Disease -log(P) Hits PubMed IDs
congenital afibrinogenemia 88.3 8
afibrinogenemia 86.3 11
dysfibrinogenemia 84.7 3
hypofibrinogenemia 71.4 5
thrombosis 68 10

Relevant External Links for FGA

Genetic Association Database (GAD)
FGA
Human Genome Epidemiology (HuGE) Navigator
FGA
genes like me logo Genes that share disorders with FGA: view

Publications for FGA Gene

  1. Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution. (PMID: 8461606) Yamazumi K. … Tsujinaka T. (Surg. Today 1993) 3 4 23
  2. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study. (PMID: 17264959) Kardys I. … de Maat M.P. (Thromb. Haemost. 2007) 3 23 49
  3. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PMID: 18278190) Carty C.L. … Reiner A.P. (Thromb. Haemost. 2008) 3 23 49
  4. Fibrinogen gene variation and ischemic stroke. (PMID: 18331453) Jood K. … Jern C. (J. Thromb. Haemost. 2008) 3 23 49
  5. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PMID: 18690352) Cheung E.Y. … Breteler M.M. (Thromb. Haemost. 2008) 3 23 49

Products for FGA Gene

Sources for FGA Gene

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