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Aliases for FGA Gene

Aliases for FGA Gene

  • Fibrinogen Alpha Chain 2 3 5
  • Fibrinogen, A Alpha Polypeptide 2 3
  • Fib2 3

External Ids for FGA Gene

Previous GeneCards Identifiers for FGA Gene

  • GC04M156353
  • GC04M155892
  • GC04M155970
  • GC04M156081
  • GC04M155826
  • GC04M155723
  • GC04M155504
  • GC04M151244

Summaries for FGA Gene

Entrez Gene Summary for FGA Gene

  • This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]

GeneCards Summary for FGA Gene

FGA (Fibrinogen Alpha Chain) is a Protein Coding gene. Diseases associated with FGA include Afibrinogenemia, Congenital and Amyloidosis, Familial Visceral. Among its related pathways are Platelet activation and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and protein binding, bridging. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for FGA Gene

  • Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGA Gene

Genomics for FGA Gene

Regulatory Elements for FGA Gene

Enhancers for FGA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGA on UCSC Golden Path with GeneCards custom track

Promoters for FGA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGA on UCSC Golden Path with GeneCards custom track

Genomic Location for FGA Gene

Chromosome:
4
Start:
154,583,126 bp from pter
End:
154,590,766 bp from pter
Size:
7,641 bases
Orientation:
Minus strand

Genomic View for FGA Gene

Genes around FGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGA Gene

Proteins for FGA Gene

  • Protein details for FGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02671-FIBA_HUMAN
    Recommended name:
    Fibrinogen alpha chain
    Protein Accession:
    P02671
    Secondary Accessions:
    • A8K3E4
    • D3DP14
    • D3DP15
    • Q4QQH7
    • Q9BX62
    • Q9UCH2

    Protein attributes for FGA Gene

    Size:
    866 amino acids
    Molecular mass:
    94973 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

    Three dimensional structures from OCA and Proteopedia for FGA Gene

    Alternative splice isoforms for FGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGA Gene

Proteomics data for FGA Gene at MOPED

Post-translational modifications for FGA Gene

  • About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
  • O-glycosylated.
  • Phosphorylated by FAM20C in the extracellular medium.
  • The alpha chain is normally not N-glycosylated (PubMed:23151259), even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells (PubMed:9689040). It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies (PubMed:16335952 and PubMed:19159218), but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency.
  • Glycosylation at Thr 107, Thr 252, Thr 283, Thr 320, Ser 351, Ser 453, Thr 525, Ser 562, Ser 586, Thr 616, and Asn 686
  • Modification sites at PhosphoSitePlus

Other Protein References for FGA Gene

No data available for DME Specific Peptides for FGA Gene

Domains & Families for FGA Gene

Suggested Antigen Peptide Sequences for FGA Gene

Graphical View of Domain Structure for InterPro Entry

P02671

UniProtKB/Swiss-Prot:

FIBA_HUMAN :
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGA: view

Function for FGA Gene

Molecular function for FGA Gene

GENATLAS Biochemistry:
fibrinogen,alpha polypeptide,63kDa (see FG@)
UniProtKB/Swiss-Prot Function:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
genes like me logo Genes that share phenotypes with FGA: view

Human Phenotype Ontology for FGA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGA Gene

MGI Knock Outs for FGA:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FGA Gene

Localization for FGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGA Gene COMPARTMENTS Subcellular localization image for FGA gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 3
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031093 platelet alpha granule lumen TAS --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with FGA: view

Pathways & Interactions for FGA Gene

SuperPathways for FGA Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Formation of Fibrin Clot (Clotting Cascade)
3 Integrin alphaIIb beta3 signaling
4 Platelet activation, signaling and aggregation
5 Collagen biosynthesis and modifying enzymes
genes like me logo Genes that share pathways with FGA: view

SIGNOR curated interactions for FGA Gene

Activates:

Gene Ontology (GO) - Biological Process for FGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002576 platelet degranulation TAS --
GO:0006461 protein complex assembly IMP 18676163
GO:0006953 acute-phase response IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with FGA: view

Drugs & Compounds for FGA Gene

(34) Drugs for FGA Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alteplase Approved Pharma activator, Target 0
Anistreplase Approved Pharma activator, Target 0
Reteplase Approved Pharma activator, Target 6
Sucralfate Approved Pharma Target, antagonist 10
Tenecteplase Approved Pharma Target 40

(39) Additional Compounds for FGA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGA: view

Transcripts for FGA Gene

mRNA/cDNA for FGA Gene

Unigene Clusters for FGA Gene

Fibrinogen alpha chain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGA Gene

No ASD Table

Relevant External Links for FGA Gene

GeneLoc Exon Structure for
FGA
ECgene alternative splicing isoforms for
FGA

Expression for FGA Gene

mRNA expression in normal human tissues for FGA Gene

mRNA differential expression in normal tissues according to GTEx for FGA Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for FGA Gene

This gene is overexpressed in Lavage (15.6), Plasma (9.9), and Synovial fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGA Gene



SOURCE GeneReport for Unigene cluster for FGA Gene Hs.351593

mRNA Expression by UniProt/SwissProt for FGA Gene

P02671-FIBA_HUMAN
Tissue specificity: Detected in blood plasma (at protein level).
genes like me logo Genes that share expression patterns with FGA: view

Protein tissue co-expression partners for FGA Gene

- Elite partner

Primer Products

Orthologs for FGA Gene

This gene was present in the common ancestor of animals.

Orthologs for FGA Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FGA 35
  • 82.69 (n)
  • 76.73 (a)
FGA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fga 35
  • 77.35 (n)
  • 73.79 (a)
Fga 16
Fga 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGA 35
  • 98.73 (n)
  • 97.11 (a)
FGA 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fga 35
  • 77.45 (n)
  • 74.07 (a)
cow
(Bos Taurus)
Mammalia FGA 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGA 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGA 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGA 35
  • 59.98 (n)
  • 50.9 (a)
FGA 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGA 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fga 35
  • 60.41 (n)
  • 52.59 (a)
Str.8667 35
African clawed frog
(Xenopus laevis)
Amphibia fga-prov 35
zebrafish
(Danio rerio)
Actinopterygii fga 35
  • 54.01 (n)
  • 49.3 (a)
wufb59b03 35
fga 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1791 37
  • 38 (a)
CG8642 37
  • 42 (a)
sca 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for FGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGA Gene

ENSEMBL:
Gene Tree for FGA (if available)
TreeFam:
Gene Tree for FGA (if available)

Paralogs for FGA Gene

Paralogs for FGA Gene

(6) SIMAP similar genes for FGA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FGA: view

Variants for FGA Gene

Sequence variations from dbSNP and Humsavar for FGA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_002390 -
VAR_002391 -
VAR_002392 Dysfibrinogenemia, congenital (DYSFIBRIN)
VAR_002393 -
VAR_002394 -

Structural Variations from Database of Genomic Variants (DGV) for FGA Gene

Variant ID Type Subtype PubMed ID
esv268285 CNV Insertion 20981092
nsv881601 CNV Loss 21882294

Variation tolerance for FGA Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGA Gene

Human Gene Mutation Database (HGMD)
FGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGA Gene

Disorders for FGA Gene

MalaCards: The human disease database

(23) MalaCards diseases for FGA Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
afibrinogenemia, congenital
  • hypofibrinogenemia, congenital
amyloidosis, familial visceral
  • amyloidosis, 3 or more types
dysfibrinogenemia, congenital
  • hypodysfibrinogenemia, congenital
dysfibrinogenemia
  • dysfibrinogenemia, congenital
afib amyloidosis
  • familial amyloid nephropathy due to fibrinogen a alpha-chain variant
- elite association - COSMIC cancer census association via MalaCards
Search FGA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FIBA_HUMAN
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. {ECO:0000269 PubMed:8097946}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:16846481, ECO:0000269 PubMed:8473507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGA

Genetic Association Database (GAD)
FGA
Human Genome Epidemiology (HuGE) Navigator
FGA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGA
genes like me logo Genes that share disorders with FGA: view

No data available for Genatlas for FGA Gene

Publications for FGA Gene

  1. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. (PMID: 8097946) Benson M.D. … Correa R. (Nat. Genet. 1993) 3 4 48 67
  2. Different expression of fibrinopeptide A and related fragments in serum of type 1 diabetic patients with nephropathy. (PMID: 19631771) Gianazza E. … Kienle M.G. (J Proteomics 2010) 3 23
  3. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PMID: 20059469) Carty C.L. … Reiner A.P. (Ann. Hum. Genet. 2010) 3 23
  4. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PMID: 20167083) Theodoraki E.V. … Dedoussis G.V. (BMC Med. Genet. 2010) 3 23
  5. Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study. (PMID: 17951283) van Oijen M. … de Maat M.P. (J. Neurol. Neurosurg. Psychiatr. 2008) 3 23

Products for FGA Gene

Sources for FGA Gene

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