V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

FGA Gene

protein-coding GIFtS: 65

GC04M155723

fibrinogen alpha chain
(Previous names: fibrinogen, A alpha polypeptide )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Fib2 ^²
MGC119422 ^²
MGC119423 ^²
MGC119425 ^²

Descriptions
fibrinogen alpha chain ^²
fibrinogen, A alpha polypeptide ^¹, ²
fibrinogen, alpha chain, isoform alpha preproprotein ^²
fibrinogen, alpha polypeptide ^²

External Ids
HGNC: 3661¹
Entrez Gene: 2243²
UniProtKB: P02671³
Ensembl: ENSG00000171560⁷

Search outside databases for aliases for FGA gene

Previous GC identifers: GC04M156353 GC04M155892 GC04M155970 GC04M156081 GC04M155826

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FGA:

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein

comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen

is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In

addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading,

display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia,

afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in

the carboxy-terminus. [provided by RefSeq]

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and

acting as a cofactor in platelet aggregation

Gene Wiki entry for FGA (Fibrinogen_alpha_chain)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FGA gene

Entrez Gene cytogenetic band: 4q28 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q28

FGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M155723: (about GC identifiers)

Start:	155,723,730 bp from pter
End:	155,731,368 bp from pter
Size:	7,639 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671 (See protein sequence)

Recommended Name: Fibrinogen alpha chain precursor

Size: 866 amino acids; 94973 Da

Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta

and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small

central domain

Subcellular location: Secreted

PDB structures from and Proteopedia :

1BBR (3D)

1FZA (3D)

1FZB (3D)

1FZC (3D)

1FZD (3D)

1FZE (3D)

1FZF (3D)

1FZG (3D)

1LT9 (3D)

1LTJ (3D)

1N86 (3D)

1N8E (3D)

1RE3 (3D)

1RE4 (3D)

1RF0 (3D)

1RF1 (3D)

1YCP (3D)

2A45 (3D)

2FFD (3D)

2H43 (3D)

2HLO (3D)

2HOD (3D)

2HPC (3D)

2OYH (3D)

2OYI (3D)

2Q9I (3D)

2Z4E (3D)

3BVH (3D)

3E1I (3D)

Secondary accessions: Q9BX62 Q9UCH2

Alternative splicing: 2 isoforms: P02671-1 P02671-2

Post-translational modifications:

The alpha chain is not glycosylated¹

Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine

residue, forming fibronectin-fibrinogen heteropolymers¹

About one-third of the alpha chains in the molecules in blood were found to be phosphorylated¹

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B

from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for

the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA

which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger)

and between alpha chains (weaker) of different monomers¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000499.1 NP_068657.1

ENSEMBL proteins:

ENSP00000384151 ENSP00000385981 ENSP00000306361

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for FGA
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (oxidized Fibrinogen, Fibrinogen, Fibrinopeptide A)
	Human Recombinant Proteins from Abnova (FGA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005577	fibrinogen complex	TAS	10467729
GO:0005886	plasma membrane	EXP	10605720
GO:0009897	external side of plasma membrane	IDA	6777381
GO:0031093	platelet alpha granule lumen	EXP	5084810

About this table

Antibodies for FGA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of FGA
	Sigma-Aldrich Antibodies for FGA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (oxidized Fibrinogen, Fibrinogen, Fibrinopeptide A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FGA)
	Novus Biologicals Antibodies for FGA

Assays for FGA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02671

ProtoNet protein and cluster: P02671

1 Blocks protein family: IPB002181 Fibrinogen

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671

Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to

the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back,

contributing a fourth strand to the coiled coil structure

Similarity: Contains 1 fibrinogen C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FGA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021871

Applied Biosystems Silencer® siRNAs for FGA

Sigma-Aldrich siRNA and siRNA Panels for FGA

Sigma-Aldrich shRNA for FGA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FGA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000508
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000508
untagged cDNA clones in CMV expression vector (see all 3): BC020764

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000508

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and

acting as a cofactor in platelet aggregation

Genatlas biochemistry entry for FGA:

fibrinogen,alpha polypeptide,63kDa (see FG@)

14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fga):

	digestive/alimentary	embryogenesis	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system
nervous system	reproductive system	skeleton	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0030674	protein binding, bridging	IEA	--
GO:0043499	eukaryotic cell surface binding	IDA	6777381

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for FGA (Your Favorite Gene powered by Ingenuity)

Coagulation System
TR/RXR Activation
Acute Phase Response Signaling

GeneDecks FGA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FGA

5/47 Interacting proteins for FGA (ENSP00000306361³ P02671^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000206318	P48634¹^,²	EBI-348571, EBI-347545 MINT-62623 MINT-62721 MINT-62797
ENSG00000206427	P48634¹^,²	EBI-348571, EBI-347545 MINT-62623 MINT-62721 MINT-62797
BAT2	P48634¹^,²	EBI-348571, EBI-347545 MINT-62623 MINT-62721 MINT-62797 EBI-348571, EBI-347545 MINT-62623 MINT-62721 MINT-62797
BAT2	P48634¹^,²	EBI-348571, EBI-347545 MINT-62623 MINT-62721 MINT-62797 EBI-348571, EBI-347545 MINT-62623 MINT-62721 MINT-62797
FGB	ENSP00000306099³	STRING (score=.999)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0030168	platelet activation	IEA	--
GO:0042246	tissue regeneration	IEA	--
GO:0051258	protein polymerization	IEA	--
GO:0051592	response to calcium ion	IDA	6777381

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FGA
10/34 Novoseek chemical compound relationships for FGA gene (see all 34 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinopeptide a	95.06	50	8459055 (4), 7539015 (4), 10369791 (3), 7646626 (3) (see all 26)
fibrinogen	91.51	299	9916133 (3), 7903170 (2), 12706644 (2), 9308756 (2) (see all 99)
hirugen	74.24	2	2380171 (1), 1590777 (1)
txb2	48.14	9	8329704 (2), 2146058 (1), 9702994 (1), 2109927 (1) (see all 7)
cuprophan	45.32	1	1325310 (1)
rsai	38.75	3	7913910 (2), 15795544 (1)
polysulfone	38.22	2	1829439 (1), 1325310 (1)
an 69	35.51	1	1601510 (1)
thromboxane a2	32.62	5	8291501 (1), 7732975 (1), 8746831 (1), 1826875 (1)
cacl2	26.66	2	1829631 (1), 1811336 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FGA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021871

Sigma-Aldrich siRNA and siRNA Panels for FGA

Sigma-Aldrich shRNA for FGA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000508 NM_021871

REFSEQ mRNAs for FGA gene (2 alternative transcripts):

NM_000508.3 NM_021871.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000508 NM_021871

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000508
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000508
                                 untagged cDNA clones in CMV expression vector (see all 3): BC020764

Additional cDNA sequence:

AK290559.1 BC020764.1 BC070246.1 BC098280.1 BC099706.1 BC099720.1 BC101935.1 BC105803.1

CR594140.1 CR608055.1 CR608485.1 CR613050.1 CR613778.1 CR617717.1 CR618112.1 CR619844.1

CR625737.1 J00127.1 J00128.1 K02272.1 M26878.1 M58569.1

24/26 DOTS entries (see all 26 ):

DT.453599 DT.100697222 DT.92460971 DT.100760439 DT.92460957 DT.100697218 DT.121267490 DT.95201336

DT.95201310 DT.92460950 DT.100697203 DT.100697204 DT.100697197 DT.100697211 DT.100697226 DT.95187527

DT.121267502 DT.100645631 DT.100697207 DT.100697217 DT.121267493 DT.92460958 DT.92460970 DT.95201326

24/761 AceView cDNA sequences (see all 761 ):

BG566426 BX448672 T68170 BX462911 CB111957 AL531832 CR608485 T40106

AL531192 BX426651 AL557888 BX494158 AA345378 CR594140 AL532526 BX346172

BG533485 BG545208 CB156911 BX494953 AL531236 BX494836 BQ644180 AL531899

highest scoring ESTs for FGA:

AA343657 AA693592 AI248502 AL531044 AL531192 AL531237 AL531263 AL531446 AL531515 AL531546

Unigene Cluster for FGA:

Fibrinogen alpha chain

Hs.351593 [show with all ESTs]

Unigene Representative Sequence: M58569

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000401984 ENST00000403106 ENST00000302053

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FGA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FGA

¹ / ² / ³

5 probe-sets matching FGA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38825_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M64982	0.20	1.00	0.72	1
205650_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021871	0.60	1.00	0.82	1
205649_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000508	0.60	1.00	0.82	1
205650_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205649_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FGA for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.351593
Expression variation in blood from EXPOLDB for FGA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FGA gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FGA¹	--	fibrinogen alpha chain	82.84(n) 76.97(a)	475473 XM_532697.2 XP_532697.2
chimpanzee (Pan troglodytes)	FGA¹	--	fibrinogen alpha chain	98.73(n) 97.11(a)	461559 XM_001136067.1 XP_001136067.1
rat (Rattus norvegicus)	Fga¹	--	fibrinogen alpha chain	78.18(n) 75.1(a)	361969 NM_001008724.1 NP_001008724.1
mouse (Mus musculus)	Fga^{1, 5}	3 (44.80 cM)⁵	fibrinogen alpha chain⁵ fibrinogen, alpha polypeptide¹	73.24(n)¹ 66.18(a)¹	14161¹ NM_010196.2¹ NP_034326.1¹ AI303526⁵ AK146828⁵ (see all 12)
chicken (Gallus gallus)	FGA¹	--	fibrinogen alpha chain	62.8(n) 56.25(a)	396307 XM_001232366.1 XP_001232367.1

About this table Species with no ortholog for FGA

ENSEMBL Gene Tree for FGA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FGA gene

FIBCD1² MFAP4² FCN2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/41 NCBI SNPs in FGA are shown (see all 41 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2070006^1,2	A,C,F,H	155733316(-)	`ATTCAG/ATACAC`	2	--	ng3¹		20	NS EU EA WA NA	1798
	rs2070011^1,2	A,C,F,H	155731347(-)	`GTGGCG/AGCAAT`	2	--	ut5¹		16	NS NA EU EA WA	2250
	rs2070008^1,2	C,F,H	155732726(-)	`gcataA/Gctcaa`	2	--	ng3¹		14	NS EU EA WA NA	2014
	rs2070025^1,2	C,F,H	155731274(-)	`TGAGGA/GTCGTC`	2	I/V	mis¹ ese³		12	NS MN EA EU WA	2180
--	rs11733832^1,2	A,C,H	155732769(+)	`catggT/Ggacta`	2	--	ng3¹		4	EU EA WA	410
--	rs2070007^1,2	C,F	155733061(-)	`ACATCT/CGGTAA`	2	--	ng3¹		5	NS NA	236
	rs2070024^1,2	F,H	155731789(-)	`ACTTAT/CAGAAA`	2	--	ng3¹		6	NS EU EA WA	470
--	rs2070009^1,2	C,F	155732391(-)	`TGTCTT/GTCTAT`	2	--	ng3¹		3	NS	1040
	rs2070010^1,2	H	155731417(-)	`ACTGTC/GTACAC`	2	--	ng3¹		6	NS EU EA WA	502
	rs2070018^1,2	A,C,F,H	155728077(-)	`TGTTTT/CTGAGT`	2	--	int¹		17	NS NA EU EA WA	1492

About this table

HapMap Linkage Disequilibrium images for FGA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134820

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671

Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare

autosomal recessive disorder characterized by bleeding that varies from mild to severe and by

complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases

of afibrinogenemia are due to truncating mutations

Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads

to alpha-dysfibrinogenemias

Defects in FGA are a cause of amyloidois type 8 (AMYL8) [MIM:105200]; also known as

systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary

generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids.

Viscera are particularly affected. There is no involvement of the nervous system. Clinical

features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension,

hepatosplenomegaly, cholestasis, petechial skin rash

10/81 Novoseek disease relationships for FGA gene (see all 81 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
congenital afibrinogenemia	88.24	7	15946522 (2), 11460507 (1), 12406899 (1), 10891444 (1) (see all 5)
afibrinogenemia	86.45	14	17295221 (2), 17393016 (1), 12406899 (1), 12511408 (1) (see all 9)
dysfibrinogenemia	84.74	2	12706644 (1), 7485081 (1)
hypofibrinogenemia	70.71	8	8426084 (2), 7489960 (1), 17295221 (1), 18676163 (1)
thrombosis	68.12	11	1295502 (1), 8348763 (1), 7554626 (1), 1433937 (1) (see all 10)
thrombophilia	68.01	8	8446931 (1), 8003387 (1), 2137945 (1), 8914220 (1) (see all 8)
disseminated intravascular coagulation	67.40	16	8426084 (5), 11460518 (1), 9308756 (1), 8039760 (1) (see all 7)
coagulopathy	56.51	7	7563081 (1), 18676163 (1), 8426084 (1), 7514043 (1) (see all 6)
thromboembolism	46.79	5	8426084 (3)
bleeding	45.81	10	11342472 (1), 8408654 (1), 8291501 (1), 7485081 (1) (see all 9)

About this table

Human Gene Mutation Database: FGA
Genetic Association Database: FGA
Human Genome Epidemiology Navigator: FGA (41 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/643 PubMed articles for FGA gene (see all 643 ):

Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. (PubMed id 8097946)^{3, 4, 6} Benson M.D.... Correa R. (1993)
Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia. (PubMed id 8473507)^{3, 4, 6} Koopman J....Caen J.P. (1993)
Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. (PubMed id 15735812)^{1, 3, 6} Mannila M.N....Silveira A. (2005)
gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians. (PubMed id 15795540)^{1, 3, 6} Ivaskevicius V....Oldenburg J. (2005)
Functional polymorphisms of FGA, encoding alpha fibrinogen, are associated with susceptibility to venous thromboembolism in a Taiwanese population. (PubMed id 16362348)^{3, 6} Ko Y.L....Lee Y.S. (2006)
Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)^{3, 4} Beranova-Giorgianni S.... Giorgianni F. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
A role of TNF-alpha gene variant on juvenile ischemic stroke: a case-control study. (PubMed id 16324093)^{3, 6} Rubattu S....Rasura M. (2005)
Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels. (PubMed id 16144795)^{3, 6} Uitte de Willige S....Bertina R.M. (2005)
Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population. (PubMed id 15968394)^{3, 6} Rubattu S....Volpe M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2243	HGNC: 3661	AceView: FGA	Ensembl:ENSG00000171560	euGenes: HUgn2243
ECgene: FGA	H-InvDB: FGA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=FGA
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FGA
Wikipedia	http://en.wikipedia.org/wiki/Fibrinogen
SeattleSNPs	http://pga.gs.washington.edu/data/fga/

Licensable Technologies for FGA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FGA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FGA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FGA		Antibodies for FGA
	Explore super-pooled esiRNAs		Proteins for FGA
	Lentivirus-delivered shRNAs for FGA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FGA)
	Antibodies (FGA)
	Chimera RNAi (FGA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (oxidized Fibrinogen, Fibrinogen, Fibrinopeptide A)
	Antibodies (oxidized Fibrinogen, Fibrinogen, Fibrinopeptide A)

Search OriGene for FGA

Search Tocris compounds for FGA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FGA

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FGA Gene at Home site.
Version 2.41.1
server5.xennexinc.com

FGA Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for FGA

Summaries
for FGA

Genomic Location
for FGA

Proteins
for FGA

Protein Domains/
Families
for FGA

Gene Function
for FGA

Pathways & Interactions
for FGA

Drugs & Compounds
for FGA

Transcripts
for FGA

Expression
for FGA

Orthologs
for FGA

Paralogs
for FGA

SNPs/Variants
for FGA

Disorders & Mutations
for FGA

Medical News
for FGA

Publications
for FGA

Search for FGA

Genome Databases showing FGA

Other Databases showing FGA

Specialized Databases showing FGA

Licensable Technologies
for FGA

Services
for FGA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FGA Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor FGA

Summariesfor FGA

Genomic Locationfor FGA

Proteinsfor FGA

Protein Domains/Familiesfor FGA

Gene Functionfor FGA

Pathways & Interactionsfor FGA

Drugs & Compoundsfor FGA

Transcriptsfor FGA

Expression for FGA

Orthologsfor FGA

Paralogsfor FGA

SNPs/Variantsfor FGA

Disorders & Mutationsfor FGA

Medical Newsfor FGA

Publicationsfor FGA

Search for FGA

Genome Databases showing FGA

Other Databases showing FGA

Specialized Databases showing FGA

Licensable Technologiesfor FGA

Servicesfor FGA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FGA

Summaries
for FGA

Genomic Location
for FGA

Proteins
for FGA

Protein Domains/
Families
for FGA

Gene Function
for FGA

Pathways & Interactions
for FGA

Drugs & Compounds
for FGA

Transcripts
for FGA

Expression
for FGA

Orthologs
for FGA

Paralogs
for FGA

SNPs/Variants
for FGA

Disorders & Mutations
for FGA

Medical News
for FGA

Publications
for FGA

Licensable Technologies
for FGA

Services
for FGA