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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGA Gene

protein-coding   GIFtS: 68
GCID: GC04M155504

Fibrinogen Alpha Chain

(Previous names: fibrinogen, A alpha polypeptide)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibrinogen Alpha Chain1 2
Fibrinogen, A Alpha Polypeptide1 2
Fib22

External Ids:    HGNC: 36611   Entrez Gene: 22432   Ensembl: ENSG000001715607   OMIM: 1348205   UniProtKB: P026713   

Export aliases for FGA gene to outside databases

Previous GC identifers: GC04M156353 GC04M155892 GC04M155970 GC04M156081 GC04M155826 GC04M155723 GC04M151244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGA Gene:
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of
three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to
form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of
fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities,
and are mitogens for several cell types. Mutations in this gene lead to several disorders, including
dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two
isoforms which vary in the carboxy-terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGA Gene: 
FGA (fibrinogen alpha chain) is a protein-coding gene. Diseases associated with FGA include dysfibrinogenemia, and congenital afibrinogenemia, and among its related super-pathways are Extrinsic Prothrombin Activation Pathway and Blood Coagulation Signaling Pathways. GO annotations related to this gene include eukaryotic cell surface binding and receptor binding. An important paralog of this gene is TNR.

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
in platelet aggregation

Gene Wiki entry for FGA (Fibrinogen alpha chain) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGA gene promoter:
         ISGF-3   Tal-1   Pbx1a   FOXO3   E47   Evi-1   FOXO3b   STAT3   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGA promoter sequence
   Search SABiosciences Chromatin IP Primers for FGA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q28

FGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M155504:  view genomic region     (about GC identifiers)

Start:
155,504,278 bp from pter      End:
155,511,918 bp from pter
Size:
7,641 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671 (See protein sequence)
Recommended Name: Fibrinogen alpha chain precursor  
Size: 866 amino acids; 94973 Da
Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2
heterotrimers are in head to head conformation with the N-termini in a small central domain
Subcellular location: Secreted
6/37 PDB 3D structures from and Proteopedia for FGA (see all 37):
1BBR (3D)        1DM4 (3D)        1FZA (3D)        1FZB (3D)        1FZC (3D)        1FZD (3D)    
Secondary accessions: D3DP14 D3DP15 Q4QQH7 Q9BX62 Q9UCH2
Alternative splicing: 2 isoforms:  P02671-1   P02671-2   (Ref.3 (AAK31372) sequence is in conflict in positions: 640:PSLSP->LPCPPRLS)

Explore the universe of human proteins at neXtProt for FGA: NX_P02671

Explore proteomics data for FGA at MOPED 

Post-translational modifications:

  • UniProtKB: The alpha chain is not glycosylated
  • UniProtKB: Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming
    fibronectin-fibrinogen heteropolymers
  • UniProtKB: About one-third of the alpha chains in the molecules in blood were found to be phosphorylated
  • UniProtKB: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and
    beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
    The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine
    cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers
  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02671

  • FGA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000499.1  NP_068657.1  

    ENSEMBL proteins: 
     ENSP00000306361   ENSP00000385981  
    Reactome Protein details: P02671
    Human Recombinant Protein Products for FGA: 
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    Novus Biologicals FGA Protein
    Novus Biologicals FGA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IEA--
    GO:0005615extracellular space IDA6777381
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--

    FGA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FIBC: Fibrinogen C domain containing

    5/6 InterPro protein domains (see all 6):
     IPR012290 Fibrinogen_a/b/g_coil_dom
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR021996 Fibrinogen_aC
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS

    Graphical View of Domain Structure for InterPro Entry P02671

    ProtoNet protein and cluster: P02671

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
    Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal
    domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to
    the coiled coil structure
    Similarity: Contains 1 fibrinogen C-terminal domain


    FGA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIBA_HUMAN, P02671
    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
    in platelet aggregation

         Genatlas biochemistry entry for FGA:
    fibrinogen,alpha polypeptide,63kDa (see FG@)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI10954706
    GO:0030674protein binding, bridging IEA--
         
    FGA for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fga):
     cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  reproductive system  skeleton  vision/eye 

    FGA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgatm1Jld for FGA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGA:
    hsa-mir-29a (MIRT005531), hsa-mir-29b (MIRT005533), hsa-mir-29c (MIRT005527), hsa-mir-144 (MIRT005529), hsa-mir-409-3p (MIRT005518)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGA
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FGA (see all 14):
    hsa-miR-600 hsa-miR-520d-5p hsa-miR-4297 hsa-miR-324-3p hsa-miR-548v hsa-miR-139-5p hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmidFGA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FGA

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FGA (NM_000508)
    Sino Biological Human cDNA Clone for FGA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGA
    Sirion Biotech Customized lentivirus for stable overexpression of FGA 
                         Customized lentivirus expression plasmids for stable overexpression of FGA 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGA About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Common Pathway
    Common Pathway0.69
    Extrinsic Prothrombin Activation Pathway0.69
    2Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Clotting Cascade0.42
    3Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    4GRB2:SOS provides linkage to MAPK signaling for Intergrins
    GRB2:SOS provides linkage to MAPK signaling for Intergrins 0.76
    p130Cas linkage to MAPK signaling for integrins0.76
    5Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    Platelet Aggregation (Plug Formation)0.73

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for FGA
        Cell adhesion Integrin inside-out signaling
    Metalloproteases in connective tissue degradation
    Cell adhesion Plasmin signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGA
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 GeneGo (Thomson Reuters) Pathways for FGA
        Cell adhesion Integrin inside-out signaling
    Cell adhesion Plasmin signaling

    1 BioSystems Pathway for FGA
        Blood Clotting Cascade


    5/14        Reactome Pathways for FGA (see all 14)
        Hemostasis
    Integrin cell surface interactions
    Response to elevated platelet cytosolic Ca2+
    p130Cas linkage to MAPK signaling for integrins
    Common Pathway

    1 PharmGKB Pathway for FGA
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for FGA):
        Complement and coagulation cascades


    FGA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for FGA (P026712, 3 ENSP000003063614) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62623 MINT-62721 MINT-62797 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62623 MINT-62721 MINT-62797 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0051258protein polymerization IEA--

    FGA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGA (FIBA)

    6 DrugBank Compounds for FGA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alteplaset-PA (see all 4)105857-23-6target--17963464 19436656 18673235
    Reteplaset- PA (see all 4)133652-38-7target--17963464 19436656 18673235
    Tenecteplaset- PA (see all 4)191588-94-0target--17963464 19436656 18673235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Anistreplaset- PA (see all 4)81669-57-0target--17139284 17016423
    Sucralfate-- 54182-58-0targetantagonist6892775

    10/65 Novoseek inferred chemical compound relationships for FGA gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinopeptide a 95.1 55 8459055 (4), 7539015 (4), 10369791 (3), 7646626 (3) (see all 27)
    fibrinogen 91.5 317 9916133 (3), 7903170 (2), 20059469 (2), 12706644 (2) (see all 99)
    heparin 78.1 62 7930274 (3), 7860920 (2), 9801927 (2), 8921778 (2) (see all 45)
    batroxobin 78.1 8 8362369 (2), 9397156 (1), 9268200 (1), 9360849 (1) (see all 6)
    hirudin 77.8 7 9868910 (1), 2380171 (1), 1587268 (1), 8571330 (1) (see all 7)
    ancrod 77.1 8 8461606 (1), 9127941 (1), 10933802 (1), 15572240 (1) (see all 7)
    hirugen 73.8 2 2380171 (1), 1590777 (1)
    nafamostat mesilate 57.8 1 8167888 (1)
    calcium heparin 57.1 1 8607111 (1)
    desirudin 56.3 2 8921778 (2)

    Search CenterWatch for drugs/clinical trials and news about FGA / FIBA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGA gene (2 alternative transcripts): 
    NM_000508.3  NM_021871.2  

    Unigene Cluster for FGA:

    Fibrinogen alpha chain
    Hs.351593  [show with all ESTs]
    Unigene Representative Sequence: M58569
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302053(uc003iod.1) ENST00000403106(uc003ioe.1 uc003iof.1)


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    hsa-miR-600 hsa-miR-520d-5p hsa-miR-4297 hsa-miR-324-3p hsa-miR-548v hsa-miR-139-5p hsa-miR-29c hsa-miR-29a
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGA

    Additional mRNA sequence: 

    AK290559.1 BC020764.1 BC070246.1 BC098280.1 BC099706.1 BC099720.1 BC101935.1 BC105803.1 
    J00127.1 J00128.1 K02272.1 M26878.1 M58569.1 

    24/26 DOTS entries (see all 26):

    DT.453599  DT.100697222  DT.92460971  DT.100760439  DT.92460957  DT.100697218  DT.121267490  DT.95201336 
    DT.95201310  DT.92460950  DT.100697203  DT.100697204  DT.100697197  DT.100697211  DT.100697226  DT.121267502 
    DT.95187527  DT.100645631  DT.100697207  DT.100697217  DT.121267493  DT.91896121  DT.92460958  DT.92460970 

    24/761 AceView cDNA sequences (see all 761):

    CB154127 BX494694 CB122971 AW827166 R06796 AL531804 CB122305 CB164382 
    BX494206 T61618 AL532082 AL531619 BG565383 BG563937 BG566426 BX462904 
    AL531263 CB154233 BX462911 BX445334 BX388063 BX427667 CB156798 BX494153 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGA expression in normal human tissues (normalized intensities)      FGA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAATGGAT
    FGA Expression
    About this image


    FGA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
             colon ; endothelial cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Human Hepatocyte (HH)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; glandular cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See FGA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGA

    SOURCE GeneReport for Unigene cluster: Hs.351593

    UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGA: 
              Atherosclerosis in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGA gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fga1 , 5 fibrinogen alpha chain1, 5 77.99(n)1
    74.05(a)1
      3 (36.96 cM)5
    141611  NM_001111048.11  NP_001104518.11 
     830261535 
    chicken
    (Gallus gallus)
    Aves FGA1 fibrinogen alpha chain 62.8(n)
    56.25(a)
      396307  XM_001232366.2  XP_001232367.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGA6
    Uncharacterized protein
    45(a)
    1 ↔ 1
    5(130255918-130266090)
    African clawed frog
    (Xenopus laevis)
    Amphibia fga-prov2 Fibrinogen, A alpha polypeptide 76.01(n)    BC041754.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb59b032 Danio rerio cDNA clone IMAGE3817673, partial cds 74.58(n)    BC054946.1 


    ENSEMBL Gene Tree for FGA (if available)
    TreeFam Gene Tree for FGA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGA gene
    TNR2  FGG2  ANGPTL42  ANGPTL32  TNXB2  TNN2  FGB2  ANGPTL52  
    TNC2  FGL12  FN12  
    6 SIMAP similar genes for FGA using alignment to 5 protein entries:     FIBA_HUMAN (see all proteins):
    FGB    FGL1    ANGPTL7    FCN3    FCN2    FCN1

    FGA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 SNPs in FGA are shown (see all 333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0107324
    Amyloidosis 8 (AMYL8)4--see VAR_0107322 R L mis40--------
    VAR_0107314
    Amyloidosis 8 (AMYL8)4--see VAR_0107312 E V mis40--------
    rs785063431,2
    Cpathogenic1155299392(-) TTCCCA/G/TTGGTA 4 R L mis10--------
    rs60501,2,4
    C,F,A,Hother1155300119(-) GAAGTA/GCTGGA 4 T A mis1 ese338Minor allele frequency- G:0.30MN NS NA EA CSA WA EU 12205
    VAR_0023904
    ----see VAR_0023902 D N mis40--------
    VAR_0023994
    ----see VAR_0023992 R S mis40--------
    VAR_0023924
    ----see VAR_0023922 R C mis40--------
    VAR_0024004
    ----see VAR_0024002 S N mis40--------
    VAR_0023984
    ----see VAR_0023982 S T mis40--------
    VAR_0023934
    ----see VAR_0023932 R H mis40--------

    HapMap Linkage Disequilibrium report for FGA (155504278 - 155511918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FGA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268285CNV Insertion20981092
    nsv881601CNV Loss21882294


    Human Gene Mutation Database (HGMD): FGA

    Locus Specific Mutation Databases (LSDB): FGA
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134820   
    OMIM disorders: 105200  202400  
    UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by
    bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet
    fibrinogen. Note=The disease is caused by mutations affecting the gene represented in this entry. The majority of
    cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of
    fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of
    apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement
    of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial
    hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/97 diseases for FGA (see all 97):    About MalaCards
    dysfibrinogenemia    congenital afibrinogenemia    amyloidosis, hereditary renal    fga-related familial visceral amyloidosis
    fga-related congenital afibrinogenemia    afibrinogenemia    acute myocarditis    chronic thromboembolic pulmonary hypertension
    hereditary amyloidosis    blood clots    coronary stenosis    amyloidosis
    disseminated intravascular coagulation    intermittent claudication    primary pulmonary hypertension    adult respiratory distress syndrome
    thrombocytosis    placental insufficiency    patent foramen ovale    antithrombin iii deficiency

    2 diseases from the University of Copenhagen DISEASES database for FGA:
    Congenital afibrinogenemia     Schizophrenia

    FGA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/82 Novoseek inferred disease relationships for FGA gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital afibrinogenemia 88.3 9 15946522 (2), 19417632 (2), 11460507 (1), 12406899 (1) (see all 6)
    afibrinogenemia 86.3 15 17295221 (2), 17393016 (1), 12406899 (1), 12511408 (1) (see all 10)
    dysfibrinogenemia 84.7 3 12706644 (1), 7485081 (1), 20510102 (1)
    hypofibrinogenemia 71.4 8 8426084 (2), 7489960 (1), 17295221 (1), 18676163 (1)
    thrombosis 68 11 1295502 (1), 8348763 (1), 7554626 (1), 1433937 (1) (see all 10)
    thrombophilia 67 8 8446931 (1), 8003387 (1), 2137945 (1), 8914220 (1) (see all 8)
    disseminated intravascular coagulation 66.7 16 8426084 (5), 11460518 (1), 9308756 (1), 8039760 (1) (see all 7)
    coagulopathy 56.1 8 7563081 (1), 18676163 (1), 19551918 (1), 8426084 (1) (see all 7)
    thromboembolism 48.5 5 8426084 (3)
    bleeding 46.8 10 11342472 (1), 8408654 (1), 8291501 (1), 7485081 (1) (see all 9)

    Genetic Association Database (GAD): FGA
    Human Genome Epidemiology (HuGE) Navigator: FGA (60 documents)

    Export disorders for FGA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGA gene, integrated from 9 sources (see all 783):
    (articles sorted by number of sources associating them with FGA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. (PubMed id 8097946)1, 2, 4 Benson M.D.... Correa R. (1993)
    2. Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia. (PubMed id 8473507)1, 2, 4 Koopman J....Caen J.P. (1993)
    3. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PubMed id 18690352)1, 4, 9 Cheung E.Y....Breteler M.M. (2008)
    4. Fibrinogen beta variants confer protection against co ronary artery disease in a Greek case-control study. (PubMed id 20167083)1, 4, 9 Theodoraki E.V....Dedoussis G.V. (2010)
    5. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study. (PubMed id 17264959)1, 4, 9 Kardys I....de Maat M.P. (2007)
    6. Interaction between fibrinogen and IL-6 genetic varia nts and associations with cardiovascular disease risk in the Cardiovascular Hea lth Study. (PubMed id 20059469)1, 4, 9 Carty C.L....Reiner A.P. (2010)
    7. Fibrinogen gene variation and ischemic stroke. (PubMed id 18331453)1, 4, 9 Jood K....Jern C. (2008)
    8. Modification of the interleukin-6 response to air pol lution by interleukin-6 and fibrinogen polymorphisms. (PubMed id 19750100)1, 4, 9 Ljungman P....Peters A. (2009)
    9. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PubMed id 18278190)1, 4, 9 Carty C.L....Reiner A.P. (2008)
    10. Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. (PubMed id 15735812)1, 4, 9 Mannila M.N....Silveira A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2243 HGNC: 3661 AceView: FGA Ensembl:ENSG00000171560 euGenes: HUgn2243
    ECgene: FGA Kegg: 2243 H-InvDB: FGA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGA Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FGA
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FGA
    Wikipedia http://en.wikipedia.org/wiki/Fibrinogen
    SeattleSNPshttp://pga.gs.washington.edu/data/fga/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGA gene:
    Search GeneIP for patents involving FGA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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