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Aliases for FFAR4 Gene

Aliases for FFAR4 Gene

  • Free Fatty Acid Receptor 4 2 3
  • Omega-3 Fatty Acid Receptor 1 2 3 4
  • GPR120 3 4 6
  • O3FAR1 3 4 6
  • PGR4 3 4 6
  • G-Protein Coupled Receptor GT01 3 4
  • G-Protein Coupled Receptor PGR4 3 4
  • G-Protein Coupled Receptor 120 3 4
  • G-Protein Coupled Receptor 129 3 4
  • GPR129 3 4
  • BMIQ10 3 6
  • G Protein-Coupled Receptor 129 2
  • G Protein-Coupled Receptor 120 2
  • GT01 3

External Ids for FFAR4 Gene

Previous Symbols for FFAR4 Gene

  • GPR129
  • GPR120
  • O3FAR1

Summaries for FFAR4 Gene

Entrez Gene Summary for FFAR4 Gene

  • This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for FFAR4 Gene

FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include fatty acid binding and taste receptor activity.

UniProtKB/Swiss-Prot for FFAR4 Gene

  • Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Tocris Summary for FFAR4 Gene

  • Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is akin to reverse-engineering this process, since the receptors have been identified but they are responding to as-yet unidentified endogenous ligands. There are approximately 150 orphan 7-TM receptors, subdivided into three classes: Class A, Class B and Class C. Orphan G-protein coupled receptors are usually identified by number (e.g. GPR35, GPR139) and as they are de-orphanized (by discovery of ligand), they sometimes maintain this prefix (e.g. GPR55). The histamine H4 (GPRv53) and GABAB receptors are further examples of de-orphanized receptors which have recently expanded existing GPCR families.

Gene Wiki entry for FFAR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FFAR4 Gene

Genomics for FFAR4 Gene

Genomic Location for FFAR4 Gene

Start:
93,566,665 bp from pter
End:
93,604,480 bp from pter
Size:
37,816 bases
Orientation:
Plus strand

Genomic View for FFAR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FFAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FFAR4 Gene

No data available for Regulatory Elements for FFAR4 Gene

Proteins for FFAR4 Gene

  • Protein details for FFAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5NUL3-FFAR4_HUMAN
    Recommended name:
    Free fatty acid receptor 4
    Protein Accession:
    Q5NUL3
    Secondary Accessions:
    • Q495H1
    • Q5VY25
    • Q5VY26
    • Q7Z605
    • Q86SM7

    Protein attributes for FFAR4 Gene

    Size:
    377 amino acids
    Molecular mass:
    42241 Da
    Quaternary structure:
    • Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.
    Miscellaneous:
    • It has been shown that FFA alpha-linolenic acid stimulates secretion of glucagon-like peptide 1 (GLP-1) from the gastro-intestinal tract (PubMed:15619630). However, this ligand is an agonist of both FFAR4 and FFAR1 and the latter has been shown to mediate GLP-1 release too (PubMed:18519800). So the precise role of FFAR4 in mediating needs to be confirmed.

    Alternative splice isoforms for FFAR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FFAR4 Gene

Proteomics data for FFAR4 Gene at MOPED

Post-translational modifications for FFAR4 Gene

Other Protein References for FFAR4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FFAR4 Gene

Domains for FFAR4 Gene

Gene Families for FFAR4 Gene

HGNC:
  • FFAR :GPCR / Class A : Fatty acid receptors

Protein Domains for FFAR4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FFAR4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q5NUL3
genes like me logo Genes that share domains with FFAR4: view

Function for FFAR4 Gene

Molecular function for FFAR4 Gene

UniProtKB/Swiss-Prot Function: Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Gene Ontology (GO) - Molecular Function for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005504 fatty acid binding ISS --
GO:0005515 protein binding --
GO:0008527 taste receptor activity IBA --
GO:0042277 NOT peptide binding IBA --
genes like me logo Genes that share ontologies with FFAR4: view
genes like me logo Genes that share phenotypes with FFAR4: view

Animal Models for FFAR4 Gene

MGI Knock Outs for FFAR4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FFAR4 Gene

Localization for FFAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FFAR4 Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with FFAR4: view

Pathways for FFAR4 Gene

genes like me logo Genes that share pathways with FFAR4: view

Gene Ontology (GO) - Biological Process for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0010827 regulation of glucose transport ISS --
GO:0032870 NOT cellular response to hormone stimulus IBA --
GO:0043066 negative regulation of apoptotic process ISS --
GO:0046879 hormone secretion IBA --
genes like me logo Genes that share ontologies with FFAR4: view

Compounds for FFAR4 Gene

(5) Tocris Compounds for FFAR4 Gene

Compound Action Cas Number
26RFa Ligand of GPR103; orexigenic neuropeptide [881640-56-8]
Grifolic acid Selective partial GPR120 agonist [80557-12-6]
PF9 tetrasodium salt Potent GPR17 agonist [851265-78-6]
TC-O 9311 Potent and selective GPR139 agonist [444932-31-4]
TUG 891 Potent and selective GPR120 agonist [1374516-07-0]
genes like me logo Genes that share compounds with FFAR4: view

Transcripts for FFAR4 Gene

mRNA/cDNA for FFAR4 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FFAR4 Gene

Free fatty acid receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FFAR4 Gene

No ASD Table

Relevant External Links for FFAR4 Gene

GeneLoc Exon Structure for
FFAR4
ECgene alternative splicing isoforms for
FFAR4

Expression for FFAR4 Gene

mRNA expression in normal human tissues for FFAR4 Gene

mRNA differential expression in normal tissues according to GTEx for FFAR4 Gene

This gene is overexpressed in Pituitary (12.8) and Colon - Transverse (9.8).

SOURCE GeneReport for Unigene cluster for FFAR4 Gene Hs.661022

mRNA Expression by UniProt/SwissProt for FFAR4 Gene

Q5NUL3-FFAR4_HUMAN
Tissue specificity: Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.
genes like me logo Genes that share expressions with FFAR4: view

Orthologs for FFAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FFAR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FFAR4 37
  • 100 (a)
OneToOne
O3FAR1 36
  • 99.82 (n)
  • 99.73 (a)
cow
(Bos Taurus)
Mammalia FFAR4 37
  • 83 (a)
OneToOne
LOC533266 36
  • 86.43 (n)
  • 85.6 (a)
dog
(Canis familiaris)
Mammalia FFAR4 37
  • 85 (a)
OneToOne
O3FAR1 36
  • 88.58 (n)
  • 88.3 (a)
mouse
(Mus musculus)
Mammalia Ffar4 36
  • 84.95 (n)
  • 86.43 (a)
Ffar4 16
Ffar4 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FFAR4 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ffar4 36
  • 85.19 (n)
  • 85 (a)
chicken
(Gallus gallus)
Aves FFAR4 37
  • 53 (a)
OneToOne
O3FAR1 36
  • 64.34 (n)
  • 57.01 (a)
lizard
(Anolis carolinensis)
Reptilia FFAR4 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ffar4 36
  • 57.7 (n)
  • 48.54 (a)
Species with no ortholog for FFAR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FFAR4 Gene

ENSEMBL:
Gene Tree for FFAR4 (if available)
TreeFam:
Gene Tree for FFAR4 (if available)

Paralogs for FFAR4 Gene

Selected SIMAP similar genes for FFAR4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FFAR4: view

No data available for Paralogs for FFAR4 Gene

Variants for FFAR4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FFAR4 Gene

Q5NUL3-FFAR4_HUMAN
Genetic variations in FFAR4 define the body mass index quantitative trait locus 10 (BMIQ10) [MIM:607514]. Variance in body mass index is a susceptibility factor for obesity

Sequence variations from dbSNP and Humsavar for FFAR4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1414929 -- 93,569,059(+) AAGCA(A/T)GGATC intron-variant
rs2065875 -- 93,577,490(+) CTTGC(C/T)CACCC intron-variant
rs2152643 -- 93,577,005(-) GTAGC(A/G)ACTGG intron-variant
rs2422267 -- 93,584,286(+) GGGGA(C/G)AGCTG intron-variant
rs2901692 -- 93,584,281(+) GGGGA(A/G)GGGAG intron-variant

Relevant External Links for FFAR4 Gene

HapMap Linkage Disequilibrium report
FFAR4
Human Gene Mutation Database (HGMD)
FFAR4

No data available for Structural Variations from Database of Genomic Variants (DGV) for FFAR4 Gene

Disorders for FFAR4 Gene

(1) OMIM Diseases for FFAR4 Gene (609044)

(1) MalaCards Diseases for FFAR4 Gene

Search for FFAR4 Gene in MalaCards »
genes like me logo Genes that share disorders with FFAR4: view

No data available for UniProtKB/Swiss-Prot for FFAR4 Gene

Publications for FFAR4 Gene

  1. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. (PMID: 15619630) Hirasawa A. … Tsujimoto G. (Nat. Med. 2005) 2 3 4 23
  2. Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. (PMID: 20471368) Burns R.N. … Moniri N.H. (Biochem. Biophys. Res. Commun. 2010) 2 3 4
  3. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. (PMID: 19723586) Moore K. … Duffy R. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2009) 2 3
  4. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. (PMID: 20813258) Oh D.Y. … Olefsky J.M. (Cell 2010) 2 3
  5. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. (PMID: 19460454) Ichimura A. … Tsujimoto G. (Prostaglandins Other Lipid Mediat. 2009) 3 23

Products for FFAR4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FFAR4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FFAR4
    • Block miRNA regulation of FFAR4 using miScript Target Protectors

    Sources for FFAR4 Gene

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