Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FFAR4 Gene

protein-coding   GIFtS: 46
GCID: GC10P095329

Free Fatty Acid Receptor 4

(Previous names: G protein-coupled receptor 129, G protein-coupled receptor...)
(Previous symbols: GPR129, GPR120, O3FAR1)
  See FFAR4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Free Fatty Acid Receptor 41 2     G-Protein Coupled Receptor 1292 3
GPR1201 2 3 5     G-Protein Coupled Receptor GT012 3
O3FAR11 2 3 5     G-Protein Coupled Receptor PGR42 3
Omega-3 Fatty Acid Receptor 11 2 3     BMIQ102 5
GPR1291 2 3     G Protein-Coupled Receptor 1201
PGR42 3 5     G Protein-Coupled Receptor 1291
G-Protein Coupled Receptor 1202 3     GT012

External Ids:    HGNC: 190611   Entrez Gene: 3385572   Ensembl: ENSG000001861887   OMIM: 6090445   UniProtKB: Q5NUL33   

Export aliases for FFAR4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FFAR4 Gene:
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded
protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing
anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for FFAR4 Gene:
FFAR4 (free fatty acid receptor 4) is a protein-coding gene. Diseases associated with FFAR4 include obesity. GO annotations related to this gene include taste receptor activity and fatty acid binding.

UniProtKB/Swiss-Prot: FFAR4_HUMAN, Q5NUL3
Function: Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway.
Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in
macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2
(ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin
sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste
of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the
regulation of adipocyte development and differentiation

summary for FFAR4 Gene:
Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally,
receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is
akin to reverse-engineering this process, since the receptors have been identified but they are responding
to as-yet unidentified endogenous ligands. There are approximately 150 orphan 7-TM receptors, subdivided
into three classes: Class A, Class B and Class C. Orphan G-protein coupled receptors are usually identified
by number (e.g. GPR35, GPR139) and as they are 'de-orphanized' (by discovery of ligand), they sometimes
maintain this prefix (e.g. GPR55). The histamine H4 (GPRv53) and GABAB receptors are further examples of
de-orphanized receptors which have recently expanded existing GPCR families.

Gene Wiki entry for FFAR4 (GPR120) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FFAR4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFFAR4 promoter sequence
   Search Chromatin IP Primers for FFAR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FFAR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23.33

FFAR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FFAR4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P095329:  view genomic region     (about GC identifiers)

Start:
95,326,422 bp from pter      End:
95,364,237 bp from pter
Size:
37,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FFAR4_HUMAN, Q5NUL3 (See protein sequence)
Recommended Name: Free fatty acid receptor 4  
Size: 377 amino acids; 42241 Da
Subunit: Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation (By similarity)
Developmental stage: Expression detected in differentiated adipocytes but not in preadipocytes
Miscellaneous: It has been shown that FFA alpha-linolenic acid stimulates secretion of glucagon-like peptide 1
(GLP-1) from the gastro-intestinal tract (PubMed:15619630). However, this ligand is an agonist of both FFAR4 and
FFAR1 and the latter has been shown to mediate GLP-1 release too (PubMed:18519800). So the precise role of FFAR4
in mediating needs to be confirmed
Secondary accessions: Q495H1 Q5VY25 Q5VY26 Q7Z605 Q86SM7
Alternative splicing: 2 isoforms:  Q5NUL3-1   Q5NUL3-2   (Specific to human)

Explore the universe of human proteins at neXtProt for FFAR4: NX_Q5NUL3

Explore proteomics data for FFAR4 at MOPED

Post-translational modifications: 

  • Phosphorylated. FFA stimulation facilitates phosphorylation1
  • Glycosylation2 at Asn21
  • Modification sites at PhosphoSitePlus

  • See FFAR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182684.1  NP_859529.2  

    ENSEMBL proteins: 
     ENSP00000360536   ENSP00000360538   ENSP00000474477  
    Reactome Protein details: Q5NUL3

    FFAR4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FFAR4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FFAR4
    GenScript Custom Purified and Recombinant Proteins Services for FFAR4
    Novus Biologicals FFAR4 Protein
    Novus Biologicals FFAR4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FFAR4 

    FFAR4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FFAR4
    OriGene Custom Antibody Services for FFAR4
    Novus Biologicals FFAR4 Antibodies
    Search for Antibodies for FFAR4 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FFAR4
    LSBio Antibodies in human, mouse, rat for FFAR4

    FFAR4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FFAR4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FFAR4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FFAR4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FFAR: GPCR / Class A : Fatty acid receptors

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q5NUL3

    ProtoNet protein and cluster: Q5NUL3

    UniProtKB/Swiss-Prot: FFAR4_HUMAN, Q5NUL3
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with FFAR4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FFAR4_HUMAN, Q5NUL3
    Function: Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway.
    Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in
    macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2
    (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin
    sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste
    of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the
    regulation of adipocyte development and differentiation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0005504fatty acid binding ISS--
    GO:0005515protein binding ----
    GO:0008527taste receptor activity IEA--
         
    Find genes that share ontologies with FFAR4           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ffar4):
     adipose tissue  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  liver/biliary system 
     nervous system  taste/olfaction 

    Find genes that share phenotypes with FFAR4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FFAR4: Ffar4tm1Sdmk Ffar4tm1Gdds Ffar4tm2Lex Ffar4tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FFAR4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FFAR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FFAR4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FFAR4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FFAR4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FFAR4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FFAR4
    Predesigned siRNA for gene silencing in human, mouse, rat FFAR4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FFAR4

    Clone
    Products:
         
    OriGene clones in human, mouse for FFAR4 (see all 8)
    OriGene ORF clones in mouse, rat for FFAR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for FFAR4
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FFAR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FFAR4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FFAR4
    Browse ESI BIO Cell Lines and PureStem Progenitors for FFAR4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FFAR4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FFAR4_HUMAN, Q5NUL3: Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalized with ARRB2
    following DHA treatment (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0016021integral component of membrane IEA--
    GO:0030139endocytic vesicle IEA--

    Find genes that share ontologies with FFAR4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FFAR4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    2Incretin Synthesis, Secretion, and Inactivation
    Incretin Synthesis, Secretion, and Inactivation0.88
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.88
    3Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCR ligand binding0.71
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Peptide hormone metabolism
    Peptide hormone metabolism0.30


    Find genes that share SuperPaths with FFAR4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for FFAR4
        Free fatty acid receptors
    Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FFAR4
    Interactions:

        Search GeneGlobe Interaction Network for FFAR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for FFAR4 (Q5NUL33 ENSP000003605384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    GCGENSP000003876624STRING: ENSP00000387662
    PCSK1ENSP000003080244STRING: ENSP00000308024
    ARR3ENSP000003115384STRING: ENSP00000311538
    ARRB1ENSP000003771414STRING: ENSP00000377141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0010827regulation of glucose transport ISS--
    GO:0046879hormone secretion IEA--
    GO:0050710negative regulation of cytokine secretion ISS--
    GO:0050728negative regulation of inflammatory response ISS--

    Find genes that share ontologies with FFAR4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FFAR4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Grifolic acidSelective partial GPR120 agonist[80557-12-6]
    26RFaLigand of GPR103; orexigenic neuropeptide[881640-56-8]
    PF9 tetrasodium saltPotent GPR17 agonist[851265-78-6]
    TC-O 9311Potent and selective GPR139 agonist[444932-31-4]
    TUG 891Potent and selective GPR120 agonist[1374516-07-0]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FFAR4 gene (2 alternative transcripts): 
    NM_001195755.1  NM_181745.3  

    Unigene Cluster for FFAR4:

    Free fatty acid receptor 4
    Hs.661022  [show with all ESTs]
    Unigene Representative Sequence: NM_181745
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371481(uc010qnu.2) ENST00000371483(uc010qnt.2) ENST00000604414

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FFAR4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FFAR4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FFAR4
    Predesigned siRNA for gene silencing in human, mouse, rat FFAR4
    Clone
    Products:
         
    OriGene clones in human, mouse for FFAR4 (see all 8)
    OriGene ORF clones in mouse, rat for FFAR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for FFAR4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FFAR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FFAR4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FFAR4
    OriGene qSTAR qPCR primer pairs in human, mouse for FFAR4
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FFAR4
      QuantiTect SYBR Green Assays in human, mouse, rat FFAR4
      QuantiFast Probe-based Assays in human, mouse, rat FFAR4

    Additional mRNA sequence: 

    AB115768.1 AK301525.1 AY255573.1 AY288417.1 BC101175.2 

    5 DOTS entries:

    DT.101978752  DT.100739096  DT.40115240  DT.406436  DT.95069573 

    9 AceView cDNA sequences:

    CR620860 AY255573 BM739118 BX444304 NM_181745 BX452518 AY288417 BM757151 
    CD517915 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FFAR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FFAR4 Expression
    About this image

    FFAR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FFAR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661022

    UniProtKB/Swiss-Prot: FFAR4_HUMAN, Q5NUL3
    Tissue specificity: Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small
    intestine and pancreas

        Custom PCR Arrays for FFAR4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FFAR4
    OriGene qSTAR qPCR primer pairs in human, mouse for FFAR4
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FFAR4
    QuantiTect SYBR Green Assays in human, mouse, rat FFAR4
    QuantiFast Probe-based Assays in human, mouse, rat FFAR4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FFAR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FFAR4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ffar41 , 5 omega-3 fatty acid receptor 15
    free fatty acid receptor 41
    84.95(n)1
    86.43(a)1
      19 (32.73 cM)5
    1072211  NM_181748.21  NP_861413.11 
     380970795 
    chicken
    (Gallus gallus)
    Aves O3FAR11 omega-3 fatty acid receptor 1 64.34(n)
    57.01(a)
      428963  XM_003641481.2  XP_003641529.2 
    lizard
    (Anolis carolinensis)
    Reptilia FFAR46
    free fatty acid receptor 4
    53(a)
    1 ↔ 1
    GL343219.1(1934901-1955964)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ffar41 free fatty acid receptor 4 57.7(n)
    48.54(a)
      100487409  XM_002937194.2  XP_002937240.2 


    ENSEMBL Gene Tree for FFAR4 (if available)
    TreeFam Gene Tree for FFAR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FFAR4 gene
    1 SIMAP similar gene for FFAR4 using alignment to 2 protein entries:     FFAR4_HUMAN (see all proteins):
    KPG_013

    Find genes that share paralogs with FFAR4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    FFAR4_HUMAN, Q5NUL3: Genetic variations in FFAR4 define the body mass index quantitative trait locus 10 (BMIQ10)
    [MIM:607514]. Variance in body mass index is a susceptibility factor for obesity


    Selected SNPs for FFAR4 (see all 603)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006316991,2
    C--95330133(+) AAAAA-/AGCAAC 2 -- int10--------
    rs723601501,2
    C--95334489(+) ATACA-/AAAAAA 2 -- int10--------
    rs749979351,2
    C--95334588(+) GGAGG-/GAG   
      G
    /GGAG
    TTGCA
    2 -- int10--------
    rs3696033671,2
    C--95344404(+) CACAG-/AAGCAA 2 -- int10--------
    rs666055431,2
    C--95348153(-) AAATG-/AAAAAA 2 -- ut313Minor allele frequency- A:0.17NA CSA 6
    rs127669921,2
    C,F,H--95350116(+) gtttaC/Tgtagt 2 -- ds500125Minor allele frequency- T:0.12NS EA NA WA 2764
    rs108822741,2
    C,F,A,H--95350200(+) tccttA/Gctgca 2 -- ds50013Minor allele frequency- G:0.21NA WA 124
    rs1380280171,2
    C--95688637(+) TCTGTA/GTCTAT 2 -- us2k10--------
    rs108822671,2
    C,F,A,H--95688643(+) TCTATC/ATCATC 2 -- us2k121Minor allele frequency- A:0.34NS EA NA WA CSA 2340
    rs3767464511,2
    C--95688709(+) TACTT-/TCTC  
            
    TCTCT
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FFAR4 (95326422 - 95364237 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FFAR4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FFAR4
    DNA2.0 Custom Variant and Variant Library Synthesis for FFAR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609044   
    OMIM disorders: 607514  
    1 disease for FFAR4:    
    About MalaCards
    obesity


    Find genes that share disorders with FFAR4           About GenesLikeMe


    Export disorders for FFAR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FFAR4 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FFAR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. (PubMed id 15619630)1, 2, 3, 9 Hirasawa A.... Tsujimoto G. (Nat. Med. 2005)
    2. Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. (PubMed id 20471368)1, 2, 3 Burns R.N. and Moniri N.H. (Biochem. Biophys. Res. Commun. 2010)
    3. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. (PubMed id 22343897)1, 2 Ichimura A....Froguel P. (Nature 2012)
    4. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. (PubMed id 20813258)1, 3 Oh D.Y....Olefsky J.M. (Cell 2010)
    5. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. (PubMed id 19723586)1, 3 Moore K....Duffy R. (amp 2009)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)1, 2 Fredriksson R....Schioeth H.B. (FEBS Lett. 2003)
    8. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2 Vassilatis D.K.... Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    9. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. (PubMed id 19460454)1, 9 Ichimura A....Tsujimoto G. (amp 2009)
    10. Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of ThrA^a8'a8^, SerA^a8/a8^, and SerA^a8/a8^ in the C-terminal tail. (PubMed id 24412271)1 Burns R.N....Moniri N.H. (Biochem. Pharmacol. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 338557 HGNC: 19061 AceView: GPR120 Ensembl:ENSG00000186188 euGenes: HUgn338557
    ECgene: FFAR4 H-InvDB: FFAR4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FFAR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FFAR4 gene:
    Search GeneIP for patents involving FFAR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for FFAR4 (GPR120/O3FAR1)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FFAR4   OriGene RNAi products in human, mouse, rat for FFAR4  
     OriGene qPCR primer pairs and template standards for FFAR4   OriGene Protein Over-expression Lysate for FFAR4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FFAR4  
     OriGene qSTAR qPCR primer pairs in human, mouse for FFAR4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FFAR4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FFAR4   OriGene Custom Protein Services for FFAR4  

     
     
     Block miRNA regulation of human, mouse, rat FFAR4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FFAR4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FFAR4 Predesigned siRNA for gene silencing in human, mouse, rat FFAR4
     QuantiFast Probe-based Assays in human, mouse, rat FFAR4 QuantiTect SYBR Green Assays in human, mouse, rat FFAR4
     Custom PCR Arrays for FFAR4 Search Chromatin IP Primers for FFAR4
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FFAR4 Search GeneGlobe Interaction Network for FFAR4
     Search Regulatory tfbs for FFAR4
     GenScript Custom Purified and Recombinant Proteins Services for FFAR4 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for FFAR4
     GenScript Custom Assay Services for FFAR4 GenScript Custom overexpressing Cell Line Services for FFAR4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for FFAR4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FFAR4 antibodies
     FFAR4 proteins
     FFAR4 lysates
     Search for Antibodies for FFAR4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FFAR4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FFAR4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FFAR4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FFAR4
     SwitchGear Promoter luciferase reporter plasmids for FFAR4
     ThermoFisher Antibody for FFAR4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FFAR4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FFAR4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FFAR4
     LSBio Antibodies in human, mouse, rat for FFAR4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FFAR4
      Search eBioscience for proteins for FFAR4
      Search eBioscience for elisas for FFAR4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FFAR4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4