Aliases for FFAR4 Gene
External Ids for FFAR4 Gene
Previous Symbols for FFAR4 Gene
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for FFAR4 Gene
FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include fatty acid binding and taste receptor activity.
UniProtKB/Swiss-Prot for FFAR4 Gene
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is akin to reverse-engineering this process, since the receptors have been identified but they are responding to as-yet unidentified endogenous ligands. There are approximately 150 orphan 7-TM receptors, subdivided into three classes: Class A, Class B and Class C. Orphan G-protein coupled receptors are usually identified by number (e.g. GPR35, GPR139) and as they are de-orphanized (by discovery of ligand), they sometimes maintain this prefix (e.g. GPR55). The histamine H4 (GPRv53) and GABAB receptors are further examples of de-orphanized receptors which have recently expanded existing GPCR families.