Aliases for FFAR4 Gene
External Ids for FFAR4 Gene
Previous HGNC Symbols for FFAR4 Gene
Previous GeneCards Identifiers for FFAR4 Gene
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for FFAR4 Gene
FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include Obesity. Among its related pathways are Incretin synthesis, secretion, and inactivation and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity.
UniProtKB/Swiss-Prot for FFAR4 Gene
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.