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Aliases for FFAR4 Gene

Aliases for FFAR4 Gene

  • Free Fatty Acid Receptor 4 2 3 5
  • Omega-3 Fatty Acid Receptor 1 2 3 4
  • G-Protein Coupled Receptor GT01 3 4
  • G-Protein Coupled Receptor PGR4 3 4
  • G-Protein Coupled Receptor 120 3 4
  • G-Protein Coupled Receptor 129 3 4
  • GPR120 3 4
  • GPR129 3 4
  • O3FAR1 3 4
  • PGR4 3 4
  • G Protein-Coupled Receptor 129 2
  • G Protein-Coupled Receptor 120 2
  • BMIQ10 3
  • GT01 3

External Ids for FFAR4 Gene

Previous HGNC Symbols for FFAR4 Gene

  • GPR129
  • GPR120
  • O3FAR1

Previous GeneCards Identifiers for FFAR4 Gene

  • GC10P095329

Summaries for FFAR4 Gene

Entrez Gene Summary for FFAR4 Gene

  • This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for FFAR4 Gene

FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include Obesity. Among its related pathways are Incretin synthesis, secretion, and inactivation and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity.

UniProtKB/Swiss-Prot for FFAR4 Gene

  • Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Gene Wiki entry for FFAR4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FFAR4 Gene

Genomics for FFAR4 Gene

Regulatory Elements for FFAR4 Gene

Enhancers for FFAR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F093591 0.9 Ensembl ENCODE 12.1 +25.6 25575 1.2 PAF1 SOX13 NR2F1 HLF YY1 NR2F2 SSRP1 IKZF1 SPI1 PDE6C FFAR4 RBP4 GC10P093599 GC10P093568
GH10F093514 0.9 Ensembl ENCODE 10.9 -50.6 -50603 2.4 KLF1 BHLHE40 REST ZIC2 ATF2 NR2F2 ZNF664 FOSL1 ZNF335 ZNF652 CEP55 FFAR4 CYP26A1 GC10M093511 RNA5SP323 GC10M093549
GH10F093572 0.4 Ensembl 10.7 +7.2 7197 1.2 ETV1 FFAR4 RBP4 GC10P093568 GC10P093599
GH10F093550 0.4 ENCODE 7 -15.4 -15386 0.2 SAP130 FFAR4 GC10M093549 GC10M093511 RNA5SP323
GH10F093567 0.7 FANTOM5 2.4 +1.8 1840 0.1 ZFP69B RNF2 IKZF1 ZBTB8A ZBTB20 EZH2 FFAR4 GC10P093568
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FFAR4 on UCSC Golden Path with GeneCards custom track

Promoters for FFAR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001762999 596 401 CTCF KLF1 SUZ12 INSM2 ZNF76 KLF17 MAX CEBPG GLI4 ZIC2

Genomic Location for FFAR4 Gene

Chromosome:
10
Start:
93,566,204 bp from pter
End:
93,604,480 bp from pter
Size:
38,277 bases
Orientation:
Plus strand

Genomic View for FFAR4 Gene

Genes around FFAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FFAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FFAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FFAR4 Gene

Proteins for FFAR4 Gene

  • Protein details for FFAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5NUL3-FFAR4_HUMAN
    Recommended name:
    Free fatty acid receptor 4
    Protein Accession:
    Q5NUL3
    Secondary Accessions:
    • Q495H1
    • Q5VY25
    • Q5VY26
    • Q7Z605
    • Q86SM7

    Protein attributes for FFAR4 Gene

    Size:
    377 amino acids
    Molecular mass:
    42241 Da
    Quaternary structure:
    • Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.
    Miscellaneous:
    • It has been shown that FFA alpha-linolenic acid stimulates secretion of glucagon-like peptide 1 (GLP-1) from the gastro-intestinal tract (PubMed:15619630). However, this ligand is an agonist of both FFAR4 and FFAR1 and the latter has been shown to mediate GLP-1 release too (PubMed:18519800). So the precise role of FFAR4 in mediating needs to be confirmed.

    Alternative splice isoforms for FFAR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FFAR4 Gene

Post-translational modifications for FFAR4 Gene

Other Protein References for FFAR4 Gene

No data available for DME Specific Peptides for FFAR4 Gene

Domains & Families for FFAR4 Gene

Gene Families for FFAR4 Gene

Protein Domains for FFAR4 Gene

Suggested Antigen Peptide Sequences for FFAR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5NUL3

UniProtKB/Swiss-Prot:

FFAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FFAR4: view

Function for FFAR4 Gene

Molecular function for FFAR4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Gene Ontology (GO) - Molecular Function for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005504 fatty acid binding IEA,ISS --
GO:0008289 lipid binding IEA --
GO:0008527 taste receptor activity IEA,IBA --
GO:0042277 NOT peptide binding IBA --
genes like me logo Genes that share ontologies with FFAR4: view
genes like me logo Genes that share phenotypes with FFAR4: view

Animal Models for FFAR4 Gene

MGI Knock Outs for FFAR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for FFAR4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FFAR4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FFAR4 Gene

Localization for FFAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FFAR4 Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FFAR4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with FFAR4: view

Pathways & Interactions for FFAR4 Gene

genes like me logo Genes that share pathways with FFAR4: view

Interacting Proteins for FFAR4 Gene

Gene Ontology (GO) - Biological Process for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0010827 regulation of glucose transport IEA,ISS --
GO:0032870 NOT cellular response to hormone stimulus IBA --
GO:0043066 negative regulation of apoptotic process IEA,ISS --
genes like me logo Genes that share ontologies with FFAR4: view

No data available for SIGNOR curated interactions for FFAR4 Gene

Drugs & Compounds for FFAR4 Gene

(20) Drugs for FFAR4 Gene - From: DrugBank, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
PRO-542 Investigational Pharma Target 0
TNX-355 Investigational Pharma Target 0
GSK 137647 Pharma FFA4/GPR120 antagonist,potent and selective, Potent and selective FFA4 (GPR120) agonist 0

(1) Additional Compounds for FFAR4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TC-G 1008
1621175-65-2

(5) Tocris Compounds for FFAR4 Gene

Compound Action Cas Number
GSK 137647 Potent and selective FFA4 (GPR120) agonist 349085-82-1
NIBR 189 Potent and selective EBI2 (GPR183) receptor antagonist 1599432-08-2
TC-G 1008 Potent and selective GPR39 agonist 1621175-65-2
TC-O 9311 Potent and selective GPR139 agonist 444932-31-4
TUG 891 Potent and selective FFA4 (GPR120) agonist 1374516-07-0

(7) ApexBio Compounds for FFAR4 Gene

Compound Action Cas Number
4-CMTB 300851-67-6
AH 7614 FFA4/GPR120 antagonist 6326-06-3
GPR120 modulator 1 GPR120 modulator 1050506-75-6
GPR120 modulator 2 GPR120 modulator 1050506-87-0
GSK 137647 FFA4/GPR120 antagonist,potent and selective 349085-82-1
MEDICA 16 87272-20-6
TUG 424 1082058-99-8
genes like me logo Genes that share compounds with FFAR4: view

Transcripts for FFAR4 Gene

mRNA/cDNA for FFAR4 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FFAR4 Gene

Free fatty acid receptor 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FFAR4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FFAR4 Gene

No ASD Table

Relevant External Links for FFAR4 Gene

GeneLoc Exon Structure for
FFAR4
ECgene alternative splicing isoforms for
FFAR4

Expression for FFAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FFAR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FFAR4 Gene

This gene is overexpressed in Pituitary (x12.8) and Colon - Transverse (x9.8).

NURSA nuclear receptor signaling pathways regulating expression of FFAR4 Gene:

FFAR4

SOURCE GeneReport for Unigene cluster for FFAR4 Gene:

Hs.661022

mRNA Expression by UniProt/SwissProt for FFAR4 Gene:

Q5NUL3-FFAR4_HUMAN
Tissue specificity: Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.
genes like me logo Genes that share expression patterns with FFAR4: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FFAR4 Gene

Orthologs for FFAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FFAR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FFAR4 35
  • 100 (a)
OneToOne
O3FAR1 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia O3FAR1 34
  • 88.58 (n)
FFAR4 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC533266 34
  • 86.43 (n)
FFAR4 35
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ffar4 34
  • 85.19 (n)
mouse
(Mus musculus)
Mammalia Ffar4 34 16 35
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia FFAR4 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves O3FAR1 34
  • 64.34 (n)
FFAR4 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FFAR4 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ffar4 34
  • 57.7 (n)
Species where no ortholog for FFAR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FFAR4 Gene

ENSEMBL:
Gene Tree for FFAR4 (if available)
TreeFam:
Gene Tree for FFAR4 (if available)

Paralogs for FFAR4 Gene

(1) SIMAP similar genes for FFAR4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FFAR4: view

No data available for Paralogs for FFAR4 Gene

Variants for FFAR4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FFAR4 Gene

FFAR4_HUMAN-Q5NUL3
Genetic variations in FFAR4 define the body mass index quantitative trait locus 10 (BMIQ10) [MIM:607514]. Variance in body mass index is a susceptibility factor for obesity.

Sequence variations from dbSNP and Humsavar for FFAR4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs116454156 other 93,587,284(+) GATCC(A/G)CGTGT reference, missense
rs10082458 -- 93,585,669(+) TGCCC(A/C)TATGA intron-variant
rs10082472 -- 93,585,793(+) TGGGC(A/G)GGCCC intron-variant
rs10748606 -- 93,584,874(+) GCTCA(G/T)TTTTT intron-variant
rs10786115 -- 93,589,608(+) agggg(G/T)ggggg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FFAR4 Gene

Variant ID Type Subtype PubMed ID
esv3579075 CNV loss 25503493

Variation tolerance for FFAR4 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.32; 81.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FFAR4 Gene

Human Gene Mutation Database (HGMD)
FFAR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FFAR4

Disorders for FFAR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FFAR4 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search FFAR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FFAR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FFAR4
genes like me logo Genes that share disorders with FFAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FFAR4 Gene

Publications for FFAR4 Gene

  1. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. (PMID: 15619630) Hirasawa A. … Tsujimoto G. (Nat. Med. 2005) 2 3 4 22 64
  2. Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. (PMID: 20471368) Burns R.N. … Moniri N.H. (Biochem. Biophys. Res. Commun. 2010) 2 3 4 64
  3. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. (PMID: 22343897) Ichimura A. … Froguel P. (Nature 2012) 3 4 64
  4. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. (PMID: 20813258) Oh D.Y. … Olefsky J.M. (Cell 2010) 2 3 64
  5. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. (PMID: 19723586) Moore K. … Duffy R. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2009) 2 3 64

Products for FFAR4 Gene

Sources for FFAR4 Gene

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