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Aliases for FFAR3 Gene

Aliases for FFAR3 Gene

  • Free Fatty Acid Receptor 3 2 3
  • GPR41 3 4 6
  • G Protein-Coupled Receptor 41 2 3
  • G-Protein Coupled Receptor 41 3 4
  • FFA3R 3

External Ids for FFAR3 Gene

Previous HGNC Symbols for FFAR3 Gene

  • GPR41

Previous GeneCards Identifiers for FFAR3 Gene

  • GC19P040542
  • GC19P035850
  • GC19P035851
  • GC19P035960

Summaries for FFAR3 Gene

GeneCards Summary for FFAR3 Gene

FFAR3 (Free Fatty Acid Receptor 3) is a Protein Coding gene. Diseases associated with FFAR3 include pertussis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and lipid binding. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for FFAR3 Gene

  • G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).

Gene Wiki entry for FFAR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FFAR3 Gene

Genomics for FFAR3 Gene

Regulatory Elements for FFAR3 Gene

Genomic Location for FFAR3 Gene

Start:
35,358,460 bp from pter
End:
35,360,489 bp from pter
Size:
2,030 bases
Orientation:
Plus strand

Genomic View for FFAR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FFAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FFAR3 Gene

Proteins for FFAR3 Gene

  • Protein details for FFAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14843-FFAR3_HUMAN
    Recommended name:
    Free fatty acid receptor 3
    Protein Accession:
    O14843
    Secondary Accessions:
    • B2RWM8
    • Q14CM7

    Protein attributes for FFAR3 Gene

    Size:
    346 amino acids
    Molecular mass:
    38649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FFAR3 Gene

Proteomics data for FFAR3 Gene at MOPED

Post-translational modifications for FFAR3 Gene

Other Protein References for FFAR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FFAR3 Gene

Domains for FFAR3 Gene

Gene Families for FFAR3 Gene

HGNC:
  • FFAR :GPCR / Class A : Fatty acid receptors
IUPHAR :

Protein Domains for FFAR3 Gene

Suggested Antigen Peptide Sequences for FFAR3 Gene

Graphical View of Domain Structure for InterPro Entry

O14843

UniProtKB/Swiss-Prot:

FFAR3_HUMAN :
  • O14843
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FFAR3: view

Function for FFAR3 Gene

Molecular function for FFAR3 Gene

UniProtKB/Swiss-Prot Function: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).

Gene Ontology (GO) - Molecular Function for FFAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 12496283
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FFAR3: view
genes like me logo Genes that share phenotypes with FFAR3: view

Animal Models for FFAR3 Gene

MGI Knock Outs for FFAR3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FFAR3 Gene

Localization for FFAR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FFAR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FFAR3 Gene COMPARTMENTS Subcellular localization image for FFAR3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FFAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9344866
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FFAR3: view

Pathways for FFAR3 Gene

genes like me logo Genes that share pathways with FFAR3: view

Pathways by source for FFAR3 Gene

Interacting Proteins for FFAR3 Gene

Gene Ontology (GO) - Biological Process for FFAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002385 mucosal immune response ISS --
GO:0002720 positive regulation of cytokine production involved in immune response ISS --
GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus ISS --
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 12496283
genes like me logo Genes that share ontologies with FFAR3: view

Compounds for FFAR3 Gene

(1) HMDB Compounds for FFAR3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) IUPHAR Ligand for FFAR3 Gene

Ligand Type Action Affinity Pubmed IDs
propanoic acid Agonist Full agonist 5.7
pentanoic acid Agonist Full agonist 5.4
butyric acid Agonist Full agonist 4.9
isobutyric acid Agonist Full agonist 4.8
acetic acid Agonist Full agonist 3.9
genes like me logo Genes that share compounds with FFAR3: view

Transcripts for FFAR3 Gene

mRNA/cDNA for FFAR3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FFAR3 Gene

Free fatty acid receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FFAR3 Gene

No ASD Table

Relevant External Links for FFAR3 Gene

GeneLoc Exon Structure for
FFAR3
ECgene alternative splicing isoforms for
FFAR3

Expression for FFAR3 Gene

mRNA expression in normal human tissues for FFAR3 Gene

mRNA differential expression in normal tissues according to GTEx for FFAR3 Gene

This gene is overexpressed in Whole Blood (29.0) and Adipose - Visceral (Omentum) (4.3).

SOURCE GeneReport for Unigene cluster for FFAR3 Gene Hs.248055

mRNA Expression by UniProt/SwissProt for FFAR3 Gene

O14843-FFAR3_HUMAN
Tissue specificity: Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia.
genes like me logo Genes that share expressions with FFAR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for FFAR3 Gene

Orthologs for FFAR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FFAR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToMany
FFAR3 35
  • 98.94 (n)
  • 98.55 (a)
cow
(Bos Taurus)
Mammalia FFAR3 35
  • 83.23 (n)
  • 79.81 (a)
GPR41 36
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
FFAR3 35
  • 82.3 (n)
  • 76.85 (a)
mouse
(Mus musculus)
Mammalia Ffar3 35
  • 76.58 (n)
  • 76.9 (a)
Ffar3 16
Ffar3 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ffar3 35
  • 75.58 (n)
  • 75.79 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489751 35
  • 54.32 (n)
  • 49.05 (a)
zebrafish
(Danio rerio)
Actinopterygii CU855821.1 36
  • 43 (a)
ManyToMany
CU855821.2 36
  • 41 (a)
ManyToMany
LOC100333904 35
  • 55.1 (n)
  • 49.25 (a)
si:ch73-90p23.1 36
  • 47 (a)
ManyToMany
si:dkey-211g8.6 36
  • 39 (a)
ManyToMany
si:dkey-211g8.7 36
  • 34 (a)
ManyToMany
Species with no ortholog for FFAR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FFAR3 Gene

ENSEMBL:
Gene Tree for FFAR3 (if available)
TreeFam:
Gene Tree for FFAR3 (if available)

Paralogs for FFAR3 Gene

Paralogs for FFAR3 Gene

Selected SIMAP similar genes for FFAR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FFAR3: view

Variants for FFAR3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FFAR3 Gene

O14843-FFAR3_HUMAN
The 6 amino acid differences at positions 44, 45, 174, 227, 256 and 346 between GPR42 and FFAR3, are polymorphic in the human population. The frequency of the probable inactive allele of FFAR3, with a Trp at position 174 was estimated to 1%

Sequence variations from dbSNP and Humsavar for FFAR3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs375946 -- 35,359,658(+) CCGGC(A/G)TGGAG synonymous-codon, reference
rs376987 -- 35,359,991(+) CTCAC(A/G)CCAGG utr-variant-3-prime
rs381099 -- 35,358,508(+) CATCT(A/T)TGTGC upstream-variant-2KB
rs395983 -- 35,360,383(+) CACAG(C/T)GCCTT utr-variant-3-prime
rs403862 -- 35,360,773(+) TGACA(C/T)CTCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FFAR3 Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv833810 CNV Gain 17160897
nsv173 CNV Loss 15895083
nsv2471 CNV Loss 18451855
esv2718493 CNV Deletion 23290073
nsv9712 CNV Loss 18304495
esv32683 CNV Gain+Loss 17666407
nsv828536 CNV Loss 20364138
nsv828537 CNV Loss 20364138
nsv820224 CNV Gain 19587683
esv25268 CNV Loss 19812545
nsv514897 CNV Loss 21397061
esv2421571 CNV Deletion 20811451
nsv442764 CNV CNV 18776908
nsv833811 CNV Gain 17160897
nsv498899 CNV Loss 21111241
dgv637e199 CNV Deletion 23128226

Relevant External Links for FFAR3 Gene

HapMap Linkage Disequilibrium report
FFAR3

Disorders for FFAR3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FFAR3 Gene including...

Search for FFAR3 Gene in MalaCards »
genes like me logo Genes that share disorders with FFAR3: view

No data available for UniProtKB/Swiss-Prot for FFAR3 Gene

Publications for FFAR3 Gene

  1. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. (PMID: 12711604) Le Poul E. … Detheux M. (J. Biol. Chem. 2003) 3 4 23
  2. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. (PMID: 9344866) Sawzdargo M. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  3. Expression of short-chain fatty acid receptor GPR41 in the human colon. (PMID: 19574715) Tazoe H. … Kuwahara A. (Biomed. Res. 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. (PMID: 12496283) Brown A.J. … Dowell S.J. (J. Biol. Chem. 2003) 3 4

Products for FFAR3 Gene

Sources for FFAR3 Gene

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