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FFAR2 Gene

protein-coding   GIFtS: 58
GCID: GC19P036042

Free Fatty Acid Receptor 2

(Previous name: G protein-coupled receptor 43)
(Previous symbol: GPR43)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Free Fatty Acid Receptor 21 2
GPR431 2 3 5
G Protein-Coupled Receptor 431 2
G-Protein Coupled Receptor 432 3
FFA2R2
Free Fatty Acid Activated Receptor 22

External Ids:    HGNC: 45011   Entrez Gene: 28672   Ensembl: ENSG000001262627   OMIM: 6038235   UniProtKB: O155523   
ORGUL members:         

Export aliases for FFAR2 gene to outside databases

Previous GC identifers: GC19P040633 GC19P035940 GC19P032447


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FFAR2 Gene:
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on
chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the
inflammatory response and in regulating lipid plasma levels. (provided by RefSeq, Apr 2009)

GeneCards Summary for FFAR2 Gene:
FFAR2 (free fatty acid receptor 2) is a protein-coding gene. Diseases associated with FFAR2 include pancreatitis, and breast cancer. GO annotations related to this gene include lipid binding and G-protein coupled receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: FFAR2_HUMAN, O15552
Function: Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and
elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate=
propionate = butyrate > pentanoate = formate

summary for FFAR2 Gene:
Free Fatty Acid (FFA) receptors are a group of Gq/11 protein-coupled receptors that are currently divided
into FFA1, FFA2 and FFA3 subtypes. They are concentrated in the pancreatic islet cells (particularly FFA1)
and in the brain, with lower expression levels found in adipose tissue, peripheral blood mononuclear cells,
neutrophils and monocytes. FFA receptors are involved in adenylate cyclase inhibition, phospholipase C
stimulation and cause leptin, insulin and glucagon secretion.

Gene Wiki entry for FFAR2 (Free fatty acid receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FFAR2 gene promoter:
         Max1   NF-1   NF-1/L   Pax-2   Pax-2a   CUTL1   HNF-1A   Pax-2b   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFFAR2 promoter sequence
   Search Chromatin IP Primers for FFAR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FFAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

FFAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FFAR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036042:  view genomic region     (about GC identifiers)

Start:
35,934,809 bp from pter      End:
35,942,669 bp from pter
Size:
7,861 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FFAR2_HUMAN, O15552 (See protein sequence)
Recommended Name: Free fatty acid receptor 2  
Size: 330 amino acids; 37144 Da
Secondary accessions: B0M0J9 Q4VAZ3 Q4VAZ5 Q4VBL5

Explore the universe of human proteins at neXtProt for FFAR2: NX_O15552

Explore proteomics data for FFAR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn151, Asn167
  • Modification sites at PhosphoSitePlus

  • See FFAR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005297.1  
    ENSEMBL proteins: 
     ENSP00000473159   ENSP00000246549  
    Reactome Protein details: O15552

    FFAR2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FFAR2

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    Cloud-Clone Corp. CLIAs for FFAR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FFAR: GPCR / Class A : Fatty acid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FFA2 receptor
    Free fatty acid receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013312 GPR40-rel_orph
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O15552

    ProtoNet protein and cluster: O15552

    UniProtKB/Swiss-Prot: FFAR2_HUMAN, O15552
    Similarity: Belongs to the G-protein coupled receptor 1 family


    FFAR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FFAR2_HUMAN, O15552
    Function: Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and
    elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate=
    propionate = butyrate > pentanoate = formate

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0008289lipid binding IEA--
         
    FFAR2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ffar2):
     cardiovascular system  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  respiratory system  skeleton 

    FFAR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FFAR2: Ffar2tm1Gzt Ffar2tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FFAR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FFAR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FFAR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FFAR2

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FFAR2:
    hsa-miR-1236 hsa-miR-1912
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FFAR2
    Predesigned siRNA for gene silencing in human, mouse, rat FFAR2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FFAR2 (NM_005306)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FFAR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FFAR2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FFAR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FFAR2_HUMAN, O15552: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9344866
    GO:0016021integral component of membrane ----
    GO:0042995cell projection IEA--

    FFAR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FFAR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Free fatty acid receptors
    Free fatty acid receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FFAR2
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for FFAR2
        G alpha (q) signalling events
    Free fatty acid receptors



    FFAR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FFAR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FFAR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FFAR2 (O155523 ENSP000002465494) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CCKENSP000003356574STRING: ENSP00000335657
    CCKARENSP000002955894STRING: ENSP00000295589
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9344866

    FFAR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FFAR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    4-CMTBFFA2 agonist; also exhibits positive allosteric modulatory activity[300851-67-6]
    MEDICA 16FFA1 (GPR40) agonist. Also inhibits ATP citrate lyase[87272-20-6]
    GW 9508Potent and selective FFA1 (GPR40) agonist[885101-89-3]
    TUG 424FFA1 (GPR40) agonist[1082058-99-8]

    1 HMDB Compound for FFAR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 IUPHAR Ligands for FFAR2 (FFA2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    (S)-2-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)-3-methylbutanamide
    AgonistFull agonist6.418818303
    AMG7703
    Allosteric regulatorPositive5.9 - 6.3518818303 21498659
    propanoic acid
    AgonistFull agonist3 - 4.912711604 12684041
    butyric acid
    AgonistFull agonist2.9 - 4.612711604 12684041
    acetic acid
    AgonistFull agonist3.1 - 4.512496283 12684041
    isobutyric acid
    AgonistFull agonist3.2 - 3.812711604
    pentanoic acid
    AgonistFull agonist2.8 - 312496283

    5 Novoseek inferred chemical compound relationships for FFAR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propionate 78.7 5 12496283 (1), 20004081 (1), 19448003 (1), 12711604 (1)
    butyrate 75.7 4 20004081 (1), 19448003 (1), 12711604 (1)
    valerate 74 1 12496283 (1)
    fatty acid 50.2 7 17899402 (2), 18998536 (1), 12684041 (1), 20005104 (1) (see all 5)
    calcium 0 1 12711604 (1)



    FFAR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FFAR2 gene: 
    NM_005306.2  

    Unigene Cluster for FFAR2:

    Free fatty acid receptor 2
    Hs.248056  [show with all ESTs]
    Unigene Representative Sequence: NM_005306
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601590 ENST00000599180 ENST00000246549(uc010eea.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat FFAR2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FFAR2:
    hsa-miR-1236 hsa-miR-1912
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FFAR2
      QuantiFast Probe-based Assays in human, mouse, rat FFAR2

    Additional mRNA sequence: 

    AB378083.1 BC095535.1 BC096198.3 BC096199.3 BC096200.1 BC096201.1 

    2 DOTS entries:

    DT.91747647  DT.121480603 

    20 AceView cDNA sequences:

    CN841942 CN835438 CN833525 AW015185 CK819813 CN843465 CA309917 CN841411 
    NM_005306 BM141985 CN841363 BF106231 CN833548 CN843466 CK819814 AX810701 
    BM141718 CN839425 CN842006 BM791838 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FFAR2 expression in normal human tissues (normalized intensities)      FFAR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCCCAGC
    FFAR2 Expression
    About this image


    FFAR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Spleen (Hematopoietic System)
    FFAR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FFAR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248056

    UniProtKB/Swiss-Prot: FFAR2_HUMAN, O15552
    Tissue specificity: Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in
    spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including FFAR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FFAR2
    OriGene qSTAR qPCR primer pairs in human, mouse for FFAR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FFAR2
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    QuantiFast Probe-based Assays in human, mouse, rat FFAR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FFAR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FFAR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ffar21 , 5 free fatty acid receptor 21, 5 81.82(n)1
    84.55(a)1
      7 (19.25 cM)5
    2330791  NM_001168509.11  NP_001161981.11 
     308183575 
    chicken
    (Gallus gallus)
    Aves LOC1017497871 free fatty acid receptor 3-like 63.33(n)
    55(a)
      101749787  XM_004950662.1  XP_004950719.1 
    lizard
    (Anolis carolinensis)
    Reptilia FFAR26
    free fatty acid receptor 2
    43(a)
    1 ↔ 1
    GL343281.1(383478-385890)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004864881 free fatty acid receptor 2-like 60.22(n)
    54.48(a)
      100486488  XM_002938195.2  XP_002938241.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000040951 free fatty acid receptor 2-like 56.47(n)
    50.18(a)
      100004095  XM_001920531.4  XP_001920566.1 


    ENSEMBL Gene Tree for FFAR2 (if available)
    TreeFam Gene Tree for FFAR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FFAR2 gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  F2RL22  GPR422  
    GPR1322  FFAR12  F2RL32  F2R2  
    4 SIMAP similar genes for FFAR2 using alignment to 2 protein entries:     FFAR2_HUMAN (see all proteins):
    GPR42    FFAR3    P2RY8    FFAR1

    FFAR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FFAR2 (see all 141)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs749479221,2
    C,F--35938618(+) TCAGGA/TGTGCA 1 -- us2k12Minor allele frequency- T:0.06WA EA 238
    rs1390581661,2
    --35938621(+) GGAGTC/GCAAGA 1 -- us2k10--------
    rs1499023961,2
    C--35938667(+) ATACAA/GAAATT 1 -- us2k10--------
    rs1823559581,2
    --35938771(+) TGGCGC/TCACTG 1 -- us2k10--------
    rs1379571761,2
    C--35938813(+) CCTCG-/AAAAAA 1 -- us2k10--------
    rs713529911,2
    C,F--35938824(+) AAAAAC/ACAAAA 1 -- us2k15Minor allele frequency- A:0.16NA CSA WA 244
    rs2012678241,2
    C--35938824(+) AAAAA-/CCAAAA 1 -- us2k10--------
    rs1865812351,2
    --35938858(+) AGGAGA/GAAAGC 1 -- us2k10--------
    rs741727361,2
    C--35938962(+) TTTTT-/T/TTA 
            
    AAATC
    2 -- us2k1 cds11NA 2
    rs1161637701,2
    C--35938973(+) TTTTTA/GAATCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FFAR2 (35934809 - 35942669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FFAR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833811CNV Gain17160897
    nsv833810CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603823    OMIM disorders: --

    2 diseases for FFAR2:    About MalaCards
    pancreatitis    breast cancer


    FFAR2 for disorders           About GeneDecksing


    Export disorders for FFAR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FFAR2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with FFAR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. (PubMed id 9344866)1, 2, 3 Sawzdargo M....O'Dowd B.F. (Biochem. Biophys. Res. Commun. 1997)
    2. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. (PubMed id 12496283)1, 2, 9 Brown A.J.... Dowell S.J. (J. Biol. Chem. 2003)
    3. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. (PubMed id 12684041)1, 2, 9 Nilsson N.E.... Olde B. (Biochem. Biophys. Res. Commun. 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Expression of the short-chain fatty acid receptor, GPR43, in the human colon. (PubMed id 17899402)1, 9 Karaki S....Kuwahara A. (J. Mol. Histol. 2008)
    7. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. (PubMed id 18812643)1, 9 Tazoe H....Kuwahara A. (J. Physiol. Pharmacol. 2008)
    8. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. (PubMed id 12711604)1, 9 Le Poul E.... Detheux M. (J. Biol. Chem. 2003)
    9. Receptor-specific regulation of ERK1/2 activation by members of the &quot;free fatty acid receptor&quot; family. (PubMed id 22712802)1 Seljeset S. and Siehler S. (J. Recept. Signal Transduct. Res. 2012)
    10. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs. (PubMed id 22919070)1 Hudson B.D....Milligan G. (FASEB J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2867 HGNC: 4501 AceView: GPR43 Ensembl:ENSG00000126262 euGenes: HUgn2867
    ECgene: FFAR2 H-InvDB: FFAR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FFAR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FFAR2 gene:
    Search GeneIP for patents involving FFAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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