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FFAR1 Gene

protein-coding   GIFtS: 64
GCID: GC19P035842

Free Fatty Acid Receptor 1

(Previous name: G protein-coupled receptor 40)
(Previous symbol: GPR40)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Free Fatty Acid Receptor 11 2
GPR401 2 3 5
G Protein-Coupled Receptor 401 2
G-Protein Coupled Receptor 402 3
FFA1R2
GPCR402

External Ids:    HGNC: 44981   Entrez Gene: 28642   Ensembl: ENSG000001262667   OMIM: 6038205   UniProtKB: O148423   

Export aliases for FFAR1 gene to outside databases

Previous GC identifers: GC19P040535 GC19P032350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FFAR1 Gene:
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on
chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved
in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2
diabetes. (provided by RefSeq, Apr 2009)

GeneCards Summary for FFAR1 Gene:
FFAR1 (free fatty acid receptor 1) is a protein-coding gene. Diseases associated with FFAR1 include peroxisome disorders, and refsum disease. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: FFAR1_HUMAN, O14842
Function: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase
intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this
receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated
pathway

summary for FFAR1 Gene:
Free Fatty Acid (FFA) receptors are a group of Gq/11 protein-coupled receptors that are currently divided
into FFA1, FFA2 and FFA3 subtypes. They are concentrated in the pancreatic islet cells (particularly FFA1)
and in the brain, with lower expression levels found in adipose tissue, peripheral blood mononuclear cells,
neutrophils and monocytes. FFA receptors are involved in adenylate cyclase inhibition, phospholipase C
stimulation and cause leptin, insulin and glucagon secretion.

Gene Wiki entry for FFAR1 (Free fatty acid receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FFAR1 gene promoter:
         GR   AML1a   GR-beta   Brachyury   GR-alpha   NF-kappaB   NF-kappaB1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFFAR1 promoter sequence
   Search Chromatin IP Primers for FFAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FFAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

FFAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FFAR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035842:  view genomic region     (about GC identifiers)

Start:
35,842,445 bp from pter      End:
35,843,367 bp from pter
Size:
923 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FFAR1_HUMAN, O14842 (See protein sequence)
Recommended Name: Free fatty acid receptor 1  
Size: 300 amino acids; 31457 Da
Secondary accessions: Q0VAS2 Q4VBL4

Explore the universe of human proteins at neXtProt for FFAR1: NX_O14842

Explore proteomics data for FFAR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn155
  • Modification sites at PhosphoSitePlus

  • See FFAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005294.1  
    ENSEMBL proteins: 
     ENSP00000246553  
    Reactome Protein details: O14842

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FFAR: GPCR / Class A : Fatty acid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FFA1 receptor
    Free fatty acid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013312 GPR40-rel_orph
     IPR013313 GPR40_recept_FA
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O14842

    ProtoNet protein and cluster: O14842

    UniProtKB/Swiss-Prot: FFAR1_HUMAN, O14842
    Similarity: Belongs to the G-protein coupled receptor 1 family


    FFAR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FFAR1_HUMAN, O14842
    Function: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase
    intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this
    receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated
    pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0008289lipid binding IEA--
         
    FFAR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FFAR1:
     Decreased circadian period len  Increased cell number in G2M,  

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ffar1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system  nervous system 
     taste/olfaction 

    FFAR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ffar1tm1Dgen for FFAR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FFAR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FFAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FFAR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FFAR1

    miRNA
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    miRTarBase miRNAs that target FFAR1:
    hsa-mir-335-5p (MIRT017704)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FFAR1_HUMAN, O14842: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9344866
    GO:0016021integral component of membrane ----

    FFAR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FFAR1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Incretin Synthesis, Secretion, and Inactivation
    Incretin Synthesis, Secretion, and Inactivation0.88
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)0.00
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.88
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FFAR1
        GPCRs, Class A Rhodopsin-like


    5 Reactome Pathways for FFAR1
        Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
    G alpha (q) signalling events
    Free fatty acid receptors
    Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


    1 Kegg Pathway  (Kegg details for FFAR1):
        Insulin secretion


    FFAR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FFAR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FFAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FFAR1 (O148423 ENSP000002465534) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    ADRA1DENSP000003687664STRING: ENSP00000368766
    AVPR1BENSP000003560944STRING: ENSP00000356094
    CASRENSP000002961544STRING: ENSP00000296154
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007186G-protein coupled receptor signaling pathway TAS9344866
    GO:0030073insulin secretion IEA--
    GO:0042593glucose homeostasis IEA--
    GO:0043087regulation of GTPase activity TAS--

    FFAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FFAR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    4-CMTBFFA2 agonist; also exhibits positive allosteric modulatory activity[300851-67-6]
    MEDICA 16FFA1 (GPR40) agonist. Also inhibits ATP citrate lyase[87272-20-6]
    GW 9508Potent and selective FFA1 (GPR40) agonist[885101-89-3]
    TUG 424FFA1 (GPR40) agonist[1082058-99-8]

    1 HMDB Compound for FFAR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for FFAR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetagonist16214394

    Selected IUPHAR Ligands for FFAR1 (FFA1 receptor) (see all 11)    About this table
    LigandTypeActionAffinityPubmed IDs
    TUG424
    AgonistFull agonist7.518947221
    GW9508
    AgonistFull agonist7.316702987 17699519
    Cpd B [PMID:18477808]
    AgonistFull agonist6.118477808
    GW1100
    AntagonistAntagonist616702987
    docosahexaenoic acid
    AgonistFull agonist5.4 - 612496284 12629551
    alpha-linolenic acid
    AgonistFull agonist4.6 - 5.912496284 12629551 12565875
    medica 16
    AgonistFull agonist5.912565875
    oleic acid
    AgonistFull agonist3.9 - 5.712496284 12629551 12565875
    linoleic acid
    AgonistFull agonist4.4 - 5.712496284 12629551 12565875
    rosiglitazone
    AgonistFull agonist5.612565875

    4 Novoseek inferred chemical compound relationships for FFAR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 64.3 24 19398560 (2), 18193825 (2), 18947221 (2), 19068482 (1) (see all 10)
    linoleic acid 33.7 1 16702987 (1)
    glucose 25 13 15606695 (2), 12629551 (1), 18583466 (1), 15736105 (1) (see all 7)
    calcium 0 6 18583466 (3), 15736105 (1), 16702987 (1)



    FFAR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FFAR1 gene: 
    NM_005303.2  

    Unigene Cluster for FFAR1:

    Free fatty acid receptor 1
    Hs.248127  [show with all ESTs]
    Unigene Representative Sequence: BC039436
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246553(uc002nzc.2)
    miRNA
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    Additional mRNA sequence: 

    BC039436.1 BC095536.1 BC120943.1 BC120944.1 EF611308.1 

    1 DOTS entry:

    DT.102835926 

    16 AceView cDNA sequences:

    BU782945 NM_005303 CN840742 CA776785 BI603605 AW474589 CN838449 AI570899 
    CA776363 BC039436 CN836027 AW583167 CN835754 CN840759 CA843152 CA776599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FFAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FFAR1 Expression
    About this image

    FFAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FFAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248127

    UniProtKB/Swiss-Prot: FFAR1_HUMAN, O14842
    Tissue specificity: Expressed abundantly in pancreatic beta cells

        Pathway & Disease-focused RT2 Profiler PCR Array including FFAR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FFAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FFAR1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ffar11 , 5 free fatty acid receptor 11, 5 79.33(n)1
    83(a)1
      7 (19.25 cM)5
    2330811  NM_194057.21  NP_918946.21 
     308605685 
    lizard
    (Anolis carolinensis)
    Reptilia FFAR16
    free fatty acid receptor 1
    34(a)
    1 ↔ 1
    GL343281.1(367839-368717)
    zebrafish
    (Danio rerio)
    Actinopterygii FFAR16
    free fatty acid receptor 1
    34(a)
    1 ↔ 1
    19(11252525-11253328) ENSDARG00000087828


    ENSEMBL Gene Tree for FFAR1 (if available)
    TreeFam Gene Tree for FFAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FFAR1 gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  F2RL22  
    GPR1322  GPR422  F2RL32  F2R2  
    4 SIMAP similar genes for FFAR1 using alignment to 2 protein entries:     FFAR1_HUMAN (see all proteins):
    GPCR40    GPR42    FFAR3    FFAR2

    FFAR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FFAR1 (see all 105)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774652171,2
    F--35840450(+) AAGGCG/CAGCAT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs169702641,2
    C,F,H--35840475(+) GCTCCG/AAGGTA 1 -- us2k126Minor allele frequency- A:0.14NA NS EA WA CSA 2906
    rs1142082851,2
    F--35840612(+) CCTGGA/GATTCG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1452661321,2
    C--35840617(+) AATTCA/GGAAGG 1 -- us2k10--------
    rs1476404441,2
    --35840650(+) TACACA/GCCTGA 1 -- us2k10--------
    rs1422768281,2
    C--35840737(+) CGGGCA/GCATTG 1 -- us2k10--------
    rs581742061,2
    C--35840896(+) GGACTT/CCCAGG 1 -- us2k14Minor allele frequency- C:0.20WA NA EA 360
    rs1457325541,2
    C--35840920(+) AGCTAC/TGCAGC 1 -- us2k10--------
    rs765259121,2
    --35840931(+) CGGCCA/GGTGCC 1 -- us2k10--------
    rs1904194001,2
    --35840956(+) TTGGGG/TAGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FFAR1 (35842445 - 35843367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FFAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718493CNV Deletion23290073
    nsv2471CNV Loss18451855
    nsv510765CNV Loss20534489
    nsv173CNV Loss15895083
    nsv833810CNV Gain17160897
    dgv1080e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FFAR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FFAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for FFAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603820    OMIM disorders: --

    7 diseases for FFAR1:    
    About MalaCards
    peroxisome disorders    refsum disease    pancreatitis    insulinoma
    diabetes mellitus    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for FFAR1:
    Diabetes mellitus

    FFAR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FFAR1
    Human Genome Epidemiology (HuGE) Navigator: FFAR1 (7 documents)

    Export disorders for FFAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FFAR1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with FFAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization. (PubMed id 18583466)1, 4, 9 Vettor R....Frittitta L. (J. Clin. Endocrinol. Metab. 2008)
    2. GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. (PubMed id 15736105)1, 4, 9 Ogawa T....Saruta T. (Metab. Clin. Exp. 2005)
    3. Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. (PubMed id 15606695)1, 4, 9 Hamid Y.H....Hansen T. (Diabet. Med. 2005)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Variants in the FFAR1 gene are associated with beta cell function. (PubMed id 17987108)1, 4 Kalis M....Cilio C.M. (PLoS ONE 2007)
    6. GPR40 gene expression in human pancreas and insulinoma. (PubMed id 16289108)1, 2 Tomita T.... Nakao K. (Biochem. Biophys. Res. Commun. 2005)
    7. A family of fatty acid binding receptors. (PubMed id 15684720)1, 3 Brown A.J....Briscoe C.P. (DNA Cell Biol. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The orphan G protein-coupled receptor GPR40 is activated by medium and long-chain fatty acids. (PubMed id 12496284)1, 2 Briscoe C.P.... Muir A.I. (J. Biol. Chem. 2003)
    10. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. (PubMed id 9344866)1, 2 Sawzdargo M....O'Dowd B.F. (Biochem. Biophys. Res. Commun. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2864 HGNC: 4498 AceView: GPR40 Ensembl:ENSG00000126266 euGenes: HUgn2864
    ECgene: FFAR1 Kegg: 2864 H-InvDB: FFAR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FFAR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FFAR1 gene:
    Search GeneIP for patents involving FFAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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