Subcategory (RNA class) for FFAR1 Gene
Aliases for FFAR1 Gene
External Ids for FFAR1 Gene
Previous HGNC Symbols for FFAR1 Gene
Previous GeneCards Identifiers for FFAR1 Gene
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
GeneCards Summary for FFAR1 Gene
FFAR1 (Free Fatty Acid Receptor 1) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for FFAR1 Gene
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
Free Fatty Acid (FFA) receptors are a group of Gq/11 protein-coupled receptors that are currently divided into FFA1, FFA2 and FFA3 subtypes. They are concentrated in the pancreatic islet cells (particularly FFA1) and in the brain, with lower expression levels found in adipose tissue, peripheral blood mononuclear cells, neutrophils and monocytes. FFA receptors are involved in adenylate cyclase inhibition, phospholipase C stimulation and cause leptin, insulin and glucagon secretion.