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Aliases for FFAR1 Gene

Subcategory (RNA class) for FFAR1 Gene

lncRNA

Aliases for FFAR1 Gene

  • Free Fatty Acid Receptor 1 2 3
  • GPR40 3 4 6
  • G Protein-Coupled Receptor 40 2 3
  • G-Protein Coupled Receptor 40 3 4
  • GPCR40 3
  • FFA1R 3

External Ids for FFAR1 Gene

ORGUL Members for FFAR1 Gene

Previous HGNC Symbols for FFAR1 Gene

  • GPR40

Previous GeneCards Identifiers for FFAR1 Gene

  • GC19P040535
  • GC19P035842
  • GC19P032350

Summaries for FFAR1 Gene

Entrez Gene Summary for FFAR1 Gene

  • This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]

GeneCards Summary for FFAR1 Gene

FFAR1 (Free Fatty Acid Receptor 1) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for FFAR1 Gene

  • G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Tocris Summary for FFAR1 Gene

  • Free Fatty Acid (FFA) receptors are a group of Gq/11 protein-coupled receptors that are currently divided into FFA1, FFA2 and FFA3 subtypes. They are concentrated in the pancreatic islet cells (particularly FFA1) and in the brain, with lower expression levels found in adipose tissue, peripheral blood mononuclear cells, neutrophils and monocytes. FFA receptors are involved in adenylate cyclase inhibition, phospholipase C stimulation and cause leptin, insulin and glucagon secretion.

Gene Wiki entry for FFAR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FFAR1 Gene

Genomics for FFAR1 Gene

Regulatory Elements for FFAR1 Gene

Genomic Location for FFAR1 Gene

Start:
35,351,542 bp from pter
End:
35,353,862 bp from pter
Size:
2,321 bases
Orientation:
Plus strand

Genomic View for FFAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FFAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FFAR1 Gene

Proteins for FFAR1 Gene

  • Protein details for FFAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14842-FFAR1_HUMAN
    Recommended name:
    Free fatty acid receptor 1
    Protein Accession:
    O14842
    Secondary Accessions:
    • Q0VAS2
    • Q4VBL4

    Protein attributes for FFAR1 Gene

    Size:
    300 amino acids
    Molecular mass:
    31457 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FFAR1 Gene

neXtProt entry for FFAR1 Gene

Proteomics data for FFAR1 Gene at MOPED

Post-translational modifications for FFAR1 Gene

  • Glycosylation at Asn155
  • Modification sites at PhosphoSitePlus

Other Protein References for FFAR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FFAR1 Gene

Domains for FFAR1 Gene

Gene Families for FFAR1 Gene

HGNC:
  • FFAR :GPCR / Class A : Fatty acid receptors
IUPHAR :

Protein Domains for FFAR1 Gene

Suggested Antigen Peptide Sequences for FFAR1 Gene

Graphical View of Domain Structure for InterPro Entry

O14842

UniProtKB/Swiss-Prot:

FFAR1_HUMAN :
  • O14842
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FFAR1: view

Function for FFAR1 Gene

Molecular function for FFAR1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: The receptor is strongly activated by gamma-linolenic acid, while myristate gives a lower response. It is also activated by phytanic acid and pristanic acid (PubMed:21570468). Is also activated by synthetic agonists, such as TAK-875 (fasiglifam); this compound is a partial agonist and potentiates the activity of the endogenous ligand gamma-linolenic acid (PubMed:24130766).
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Gene Ontology (GO) - Molecular Function for FFAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9344866
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0008289 lipid binding IEA --
GO:0045125 bioactive lipid receptor activity IDA 24130766
genes like me logo Genes that share ontologies with FFAR1: view
genes like me logo Genes that share phenotypes with FFAR1: view

Animal Models for FFAR1 Gene

MGI Knock Outs for FFAR1:

Animal Model Products

CRISPR Products

miRNA for FFAR1 Gene

miRTarBase miRNAs that target FFAR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FFAR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FFAR1 Gene

Localization for FFAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FFAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FFAR1 Gene COMPARTMENTS Subcellular localization image for FFAR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FFAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 25043059
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FFAR1: view

Pathways for FFAR1 Gene

genes like me logo Genes that share pathways with FFAR1: view

Pathways by source for FFAR1 Gene

1 KEGG pathway for FFAR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FFAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0030073 insulin secretion IEA --
GO:0042593 glucose homeostasis IEA --
GO:0043547 positive regulation of GTPase activity TAS --
genes like me logo Genes that share ontologies with FFAR1: view

Compounds for FFAR1 Gene

(5) Tocris Compounds for FFAR1 Gene

Compound Action Cas Number
4-CMTB FFA2 agonist; also exhibits positive allosteric modulatory activity [300851-67-6]
AH 7614 Selective FFA4 (GPR120) antagonist [6326-06-3]
GW 9508 Potent and selective FFA1 (GPR40) agonist [885101-89-3]
MEDICA 16 FFA1 (GPR40) agonist; also inhibits ATP citrate lyase [87272-20-6]
TUG 424 FFA1 (GPR40) agonist [1082058-99-8]

(1) HMDB Compounds for FFAR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for FFAR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Icosapent
  • Eicosapentaenoic acid
10417-94-4 target agonist

(11) IUPHAR Ligand for FFAR1 Gene

Ligand Type Action Affinity Pubmed IDs
TUG424 Agonist Full agonist 7.5
GW9508 Agonist Full agonist 7.3
Cpd B [PMID:18477808] Agonist Full agonist 6.1
GW1100 Antagonist Antagonist 6
docosahexaenoic acid Agonist Full agonist 6
alpha-linolenic acid Agonist Full agonist 5.9
medica 16 Agonist Full agonist 5.9
palmitic acid Agonist Full agonist 5.3
oleic acid Activator Activation
linoleic acid Channel blocker None
rosiglitazone Channel blocker None

(4) Novoseek inferred chemical compound relationships for FFAR1 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 64.3 13
linoleic acid 33.7 1
glucose 25 8
calcium 0 5
genes like me logo Genes that share compounds with FFAR1: view

Transcripts for FFAR1 Gene

mRNA/cDNA for FFAR1 Gene

(16) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FFAR1 Gene

Free fatty acid receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FFAR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FFAR1 Gene

No ASD Table

Relevant External Links for FFAR1 Gene

GeneLoc Exon Structure for
FFAR1
ECgene alternative splicing isoforms for
FFAR1

Expression for FFAR1 Gene

mRNA expression in normal human tissues for FFAR1 Gene

mRNA differential expression in normal tissues according to GTEx for FFAR1 Gene

This gene is overexpressed in Pancreas (7.4), Ovary (7.0), and Brain - Spinal cord (cervical c-1) (6.2).

SOURCE GeneReport for Unigene cluster for FFAR1 Gene Hs.248127

mRNA Expression by UniProt/SwissProt for FFAR1 Gene

O14842-FFAR1_HUMAN
Tissue specificity: Detected in brain and pancreas. Detected in pancreatic beta cells.
genes like me logo Genes that share expressions with FFAR1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for FFAR1 Gene

Orthologs for FFAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FFAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FFAR1 35
  • 99.56 (n)
  • 99.67 (a)
FFAR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FFAR1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FFAR1 35
  • 85.4 (n)
  • 85.28 (a)
FFAR1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ffar1 35
  • 79.33 (n)
  • 83 (a)
Ffar1 16
Ffar1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FFAR1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ffar1 35
  • 78.33 (n)
  • 81.67 (a)
lizard
(Anolis carolinensis)
Reptilia FFAR1 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FFAR1 36
  • 34 (a)
OneToOne
Species with no ortholog for FFAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FFAR1 Gene

ENSEMBL:
Gene Tree for FFAR1 (if available)
TreeFam:
Gene Tree for FFAR1 (if available)

Paralogs for FFAR1 Gene

Paralogs for FFAR1 Gene

Selected SIMAP similar genes for FFAR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FFAR1: view

Variants for FFAR1 Gene

Sequence variations from dbSNP and Humsavar for FFAR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1573611 -- 35,352,805(+) CTGAC(C/T)CACAG downstream-variant-500B
rs1978013 -- 35,350,954(+) GGGCC(C/T)GGCTG upstream-variant-2KB
rs1978014 -- 35,350,955(+) GGCCT(A/G)GCTGA upstream-variant-2KB
rs2301151 - 35,352,183(+) GGCCC(A/G)CTCCG missense, reference
rs10418569 -- 35,351,338(+) ACAGG(C/T)CCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FFAR1 Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv833810 CNV Gain 17160897
nsv173 CNV Loss 15895083
nsv2471 CNV Loss 18451855
esv2718493 CNV Deletion 23290073

Relevant External Links for FFAR1 Gene

HapMap Linkage Disequilibrium report
FFAR1
Human Gene Mutation Database (HGMD)
FFAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FFAR1 Gene

Disorders for FFAR1 Gene

(1) University of Copenhagen DISEASES for FFAR1 Gene

Relevant External Links for FFAR1

Genetic Association Database (GAD)
FFAR1
Human Genome Epidemiology (HuGE) Navigator
FFAR1
genes like me logo Genes that share disorders with FFAR1: view

No data available for UniProtKB/Swiss-Prot for FFAR1 Gene

Publications for FFAR1 Gene

  1. Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. (PMID: 15606695) Hamid Y.H. … Hansen T. (Diabet. Med. 2005) 3 23 48
  2. GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. (PMID: 15736105) Ogawa T. … Saruta T. (Metab. Clin. Exp. 2005) 3 23 48
  3. Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization. (PMID: 18583466) Vettor R. … Frittitta L. (J. Clin. Endocrinol. Metab. 2008) 3 23 48
  4. Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. (PMID: 19068482) Sum C.S. … Gershengorn M.C. (J. Biol. Chem. 2009) 3 4 23
  5. Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1). (PMID: 18927207) Hara T. … Tsujimoto G. (Mol. Pharmacol. 2009) 3 23

Products for FFAR1 Gene

Sources for FFAR1 Gene

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