Aliases for FEZF2 Gene
Aliases for FEZF2 Gene
External Ids for FEZF2 Gene
- HGNC: 13506
- Entrez Gene: 55079
- Ensembl: ENSG00000153266
- OMIM: 607414
- UniProtKB: Q8TBJ5
Previous HGNC Symbols for FEZF2 Gene
- ZNF312
Previous GeneCards Identifiers for FEZF2 Gene
- GC03M062331
Summaries for FEZF2 Gene
GeneCards Summary for FEZF2 Gene
FEZF2 (FEZ Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with FEZF2 include Uterine Inversion and Eyelid Neoplasm. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is FEZF1.
UniProtKB/Swiss-Prot for FEZF2 Gene
-
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZF2 Gene
Genomics for FEZF2 Gene
Regulatory Elements for FEZF2 Gene
Enhancers for FEZF2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G062437 | 0.6 | FANTOM5 | 4.3 | -62.9 | -62873 | 0.3 | NFRKB ZSCAN4 ZSCAN29 BMI1 | CADPS FEZF2 C3orf14 GC03P062465 LOC105377647 |
| GH03G062441 | 0.6 | FANTOM5 | 3.3 | -67.6 | -67614 | 0.4 | GATA3 MAZ ETV6 FOSL2 | CADPS FEZF2 GC03P062465 LOC105377647 |
| GH03G062509 | 0.5 | FANTOM5 | 2.3 | -135.6 | -135561 | 0.2 | GTF2F1 YBX1 | FEZF2 CADPS GC03P062516 GC03M062497 |
| GH03G062374 | 1.2 | VISTA ENCODE | 0.7 | -0.2 | -219 | 0.7 | ESRRA SUZ12 NFRKB CEBPG CTBP1 FOS ETV6 FOSL2 EZH2 MAZ | LOC105377647 FEZF2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FEZF2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FEZF2 gene promoter:
Regulatory Element Products
Genomic Location for FEZF2 Gene
- Chromosome:
- 3
- Start:
- 62,369,672 bp from pter
- End:
- 62,374,324 bp from pter
- Size:
- 4,653 bases
- Orientation:
- Minus strand
Genomic View for FEZF2 Gene
Genes around FEZF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p14.2 by Ensembl
- 3p14.2 by Entrez Gene
- 3p14.2 by HGNC
FEZF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FEZF2 Gene
Proteins for FEZF2 Gene
-
Protein details for FEZF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TBJ5-FEZF2_HUMAN
- Recommended name:
- Fez family zinc finger protein 2
- Protein Accession:
- Q8TBJ5
- A8K349
- Q9BZ91
- Q9NWB9
Protein attributes for FEZF2 Gene
- Size:
- 459 amino acids
- Molecular mass:
- 48811 Da
- Quaternary structure:
- No Data Available
Protein Expression for FEZF2 Gene
Post-translational modifications for FEZF2 Gene
Other Protein References for FEZF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FEZF2
- Invitrogen Antibodies for FEZF2
- antibodies-online Antibodies for FEZF2: See all 38
- GeneTex FEZF2 antibody for FEZF2
Protein Products
-
OriGene Purified Proteins for FEZF2
- Search Origene for MassSpec and Protein Over-expression Lysates for FEZF2
- Origene Custom Protein Services for FEZF2
- antibodies-online Proteins for FEZF2: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FEZF2
Assay Products
- antibodies-online Kits for FEZF2: See all 3
No data available for DME Specific Peptides for FEZF2 Gene
Domains & Families for FEZF2 Gene
Gene Families for FEZF2 Gene
Protein Domains for FEZF2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FEZF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TBJ5- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for FEZF2 Gene
Molecular function for FEZF2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | IEA | -- |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for FEZF2 Gene
- MGI mutant phenotypes for FEZF2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FEZF2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FEZF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZF2 gene
- Search ViGene Biosciences for FEZF2
CRISPR Products
-
OriGene CRISPR knockouts for FEZF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEZF2
- GenScript: Design CRISPR guide RNA sequences for FEZF2
miRNA Products
- Search ViGene Biosciences for FEZF2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEZF2
- Browse OriGene Inhibitory RNA Products For FEZF2
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZF2 gene
Clone Products
-
OriGene ORF clones in human for FEZF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for FEZF2
Cell Line Products
-
Horizon Cell Lines for FEZF2
-
ViGene Biosciences adenoviral particle packaged cDNA for FEZF2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FEZF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZF2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FEZF2 Gene
Localization for FEZF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FEZF2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for FEZF2 Gene
No Data Available
Interacting Proteins for FEZF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FEZF2 Gene
Transcripts for FEZF2 Gene
mRNA/cDNA for FEZF2 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (67) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FEZF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FEZF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEZF2
- GenScript: Design CRISPR guide RNA sequences for FEZF2
miRNA Products
- Search ViGene Biosciences for FEZF2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEZF2
- Browse OriGene Inhibitory RNA Products For FEZF2
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZF2 gene
Clone Products
-
OriGene ORF clones in human for FEZF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for FEZF2
Flow Cytometry Products
Expression for FEZF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
-
Neurons
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Brain (Nervous System)
- Neural Ectoderm (Nervous System)
mRNA differential expression in normal tissues according to GTEx for FEZF2 Gene
This gene is overexpressed in Brain - Hippocampus (x14.2), Brain - Anterior cingulate cortex (BA24) (x9.3), Brain - Amygdala (x7.4), Brain - Cortex (x7.2), and Brain - Frontal Cortex (BA9) (x6.5).
This gene is overexpressed in Brain (64.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FEZF2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FEZF2 Gene:
FEZF2SOURCE GeneReport for Unigene cluster for FEZF2 Gene:
Hs.241523Evidence on tissue expression from TISSUES for FEZF2 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for FEZF2
-
OriGene qPCR primer pairs and template standards for FEZF2
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEZF2 Gene
Orthologs for FEZF2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FEZF2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FEZF2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FEZF2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fezf2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fezf2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FEZF2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FEZF2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FEZF2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FEZF2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fezf2 34 |
|
||
| Str.17861 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fezf2 34 35 |
|
||
| fezl 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | erm 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | fezf-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FEZF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FEZF2 Gene
(41) SIMAP similar genes for FEZF2 Gene using alignment to 1 proteins:
- ZNF
- ZNF78L1
- ZNF430
- FEZF1
- ZNF260
- GFI1B
- ZNF664
- ZNF331
- ZNF72
- ZNF85
- DKFZp686M04222
- ZNF600
- ZNF585B
- ZNF323
- GFI1
- ZNF844
- ZNF80
- ZNF589
- ZNF501
- ZNF833P
- ZNF697
- ZNF660
- ZNF22
- ZFS-2
- DKFZp434J0650
- ZNF75A
- ZNF740
- ZNF273
- DKFZp434G1930
- ZNF808
- GLI4
- ZNF73
- ZNF702P
- ZNF625
- ZNF32
- ZNF696
- ZNF137P
- ZNF818P
- PLZF
- DKFZp570I0164
- ZFP41
Variants for FEZF2 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001044554 | -- | 62,371,211(+) | TGGCA(C/G)GTTAC | intron-variant | |
| rs1003033668 | -- | 62,371,733(+) | GGGGG(G/T)CCACA | intron-variant | |
| rs1003370551 | -- | 62,375,236(+) | CTCTA(A/G)TTTTA | intron-variant, upstream-variant-2KB | |
| rs1003382970 | -- | 62,373,497(+) | CCACC(A/G)CCCCT | utr-variant-5-prime | |
| rs1003501078 | -- | 62,373,176(+) | TTAAC(C/T)CCCCT | intron-variant |
Residual Variation Intolerance Score:
33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.44;
9.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FEZF2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FEZF2 Gene
Disorders for FEZF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| uterine inversion |
|
|
| eyelid neoplasm |
|
|
| partial fetal alcohol syndrome |
|
|
| lymph node tuberculosis |
|
|
| breast metaplastic carcinoma |
|
|
Search FEZF2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FEZF2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FEZF2
No data available for UniProtKB/Swiss-Prot and Genatlas for FEZF2 Gene
Publications for FEZF2 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. (PMID: 26544942) Takaba H. … Takayanagi H. (Cell 2015) 3 64
- Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system. (PMID: 24913420) Eckler M.J. … Chen B. (Bioessays 2014) 3 64
- Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. (PMID: 25319688) Berberoglu M.A. … Guo S. (J. Neurosci. 2014) 3 64
- FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma. (PMID: 23677067) Shu X.S. … Tao Q. (Carcinogenesis 2013) 3 64
Products for FEZF2 Gene
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- OriGene qPCR primer pairs for FEZF2
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- Novus Biologicals proteins and lysates for FEZF2
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- Addgene plasmids for FEZF2
- antibodies-online Antibodies for FEZF2: See all 38
- antibodies-online Kits for FEZF2: See all 3
- antibodies-online Proteins for FEZF2: See all 8
- Search antibodies-online for peptides
- GeneTex FEZF2 antibody for FEZF2
- Search GeneTex for Proteins for FEZF2
- ViGene Biosciences adenoviral particle packaged cDNA for FEZF2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FEZF2 gene
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- Search Santa Cruz Biotechnology (SCBT) for FEZF2 Antibodies
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FEZF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer