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Aliases for FEZF2 Gene

Aliases for FEZF2 Gene

  • FEZ Family Zinc Finger 2 2 3
  • Zinc Finger Protein 312 2 3 4
  • Forebrain Embryonic Zinc Finger-Like Protein 2 3 4
  • ZNF312 3 4
  • FEZL 3 4
  • Zinc Finger Protein Fez-Like 4
  • FKSG36 3
  • ZFP312 3
  • TOF 3
  • FEZ 3

External Ids for FEZF2 Gene

Previous HGNC Symbols for FEZF2 Gene

  • ZNF312

Previous GeneCards Identifiers for FEZF2 Gene

  • GC03M062331

Summaries for FEZF2 Gene

GeneCards Summary for FEZF2 Gene

FEZF2 (FEZ Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with FEZF2 include atrial septal defect 2 and atrioventricular septal defect 4. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is GFI1.

UniProtKB/Swiss-Prot for FEZF2 Gene

  • Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZF2 Gene

Genomics for FEZF2 Gene

Regulatory Elements for FEZF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FEZF2 Gene

Chromosome:
3
Start:
62,369,672 bp from pter
End:
62,374,324 bp from pter
Size:
4,653 bases
Orientation:
Minus strand

Genomic View for FEZF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FEZF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEZF2 Gene

Proteins for FEZF2 Gene

  • Protein details for FEZF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBJ5-FEZF2_HUMAN
    Recommended name:
    Fez family zinc finger protein 2
    Protein Accession:
    Q8TBJ5
    Secondary Accessions:
    • A8K349
    • Q9BZ91
    • Q9NWB9

    Protein attributes for FEZF2 Gene

    Size:
    459 amino acids
    Molecular mass:
    48811 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FEZF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FEZF2 Gene

Proteomics data for FEZF2 Gene at MOPED

Post-translational modifications for FEZF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEZF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FEZF2 Gene

Domains & Families for FEZF2 Gene

Gene Families for FEZF2 Gene

Protein Domains for FEZF2 Gene

Suggested Antigen Peptide Sequences for FEZF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBJ5

UniProtKB/Swiss-Prot:

FEZF2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with FEZF2: view

Function for FEZF2 Gene

Molecular function for FEZF2 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).

Gene Ontology (GO) - Molecular Function for FEZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with FEZF2: view
genes like me logo Genes that share phenotypes with FEZF2: view

Animal Models for FEZF2 Gene

MGI Knock Outs for FEZF2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FEZF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for FEZF2 Gene

Localization for FEZF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEZF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FEZF2 Gene COMPARTMENTS Subcellular localization image for FEZF2 gene
Compartment Confidence
nucleus 3
extracellular 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FEZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FEZF2: view

Pathways & Interactions for FEZF2 Gene

SuperPathways for FEZF2 Gene

No Data Available

Interacting Proteins for FEZF2 Gene

Gene Ontology (GO) - Biological Process for FEZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007411 axon guidance IBA --
GO:0007413 axonal fasciculation IEA --
genes like me logo Genes that share ontologies with FEZF2: view

No data available for Pathways by source and SIGNOR curated interactions for FEZF2 Gene

Drugs & Compounds for FEZF2 Gene

No Compound Related Data Available

Transcripts for FEZF2 Gene

Unigene Clusters for FEZF2 Gene

FEZ family zinc finger 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FEZF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEZF2 Gene

No ASD Table

Relevant External Links for FEZF2 Gene

GeneLoc Exon Structure for
FEZF2
ECgene alternative splicing isoforms for
FEZF2

Expression for FEZF2 Gene

mRNA expression in normal human tissues for FEZF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEZF2 Gene

This gene is overexpressed in Brain - Hippocampus (x14.2), Brain - Anterior cingulate cortex (BA24) (x9.3), Brain - Amygdala (x7.4), Brain - Cortex (x7.2), and Brain - Frontal Cortex (BA9) (x6.5).

Protein differential expression in normal tissues from HIPED for FEZF2 Gene

This gene is overexpressed in Brain (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FEZF2 Gene



SOURCE GeneReport for Unigene cluster for FEZF2 Gene Hs.241523

genes like me logo Genes that share expression patterns with FEZF2: view

Protein tissue co-expression partners for FEZF2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FEZF2 Gene

Orthologs for FEZF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FEZF2 35
  • 93.52 (n)
  • 96.94 (a)
FEZF2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FEZF2 35
  • 95.21 (n)
  • 98.26 (a)
FEZF2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fezf2 35
  • 90.75 (n)
  • 96.48 (a)
Fezf2 16
Fezf2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FEZF2 35
  • 99.85 (n)
  • 100 (a)
FEZF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fezf2 35
  • 90.9 (n)
  • 95.59 (a)
oppossum
(Monodelphis domestica)
Mammalia FEZF2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FEZF2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FEZF2 35
  • 78.53 (n)
  • 80.7 (a)
FEZF2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FEZF2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fezf2 35
  • 73.1 (n)
  • 78.37 (a)
Str.17861 35
zebrafish
(Danio rerio)
Actinopterygii fezf2 35
  • 70.39 (n)
  • 74.27 (a)
fezl 35
fezf2 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta erm 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fezf-1 36
  • 66 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
OneToMany
Species with no ortholog for FEZF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEZF2 Gene

ENSEMBL:
Gene Tree for FEZF2 (if available)
TreeFam:
Gene Tree for FEZF2 (if available)

Paralogs for FEZF2 Gene

Paralogs for FEZF2 Gene

genes like me logo Genes that share paralogs with FEZF2: view

Variants for FEZF2 Gene

Sequence variations from dbSNP and Humsavar for FEZF2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1139340 -- 62,372,029(-) TGCGA(A/G)GTGTG synonymous-codon, reference
rs3215030 -- 62,369,991(+) TATAG(-/T)TTTTT utr-variant-3-prime
rs9851074 -- 62,372,911(+) CGCAG(A/C)CTCTC utr-variant-5-prime, reference, missense
rs11554211 -- 62,371,651(-) TCACT(A/G)TAATC reference, missense
rs12492501 -- 62,372,921(+) CTCCT(C/G)TAAGT utr-variant-5-prime, missense, reference

Variation tolerance for FEZF2 Gene

Residual Variation Intolerance Score: 33.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEZF2 Gene

HapMap Linkage Disequilibrium report
FEZF2
Human Gene Mutation Database (HGMD)
FEZF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FEZF2 Gene

Disorders for FEZF2 Gene

MalaCards: The human disease database

(13) MalaCards diseases for FEZF2 Gene - From: OMIM and DISEASES

- elite association
Search FEZF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FEZF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FEZF2
genes like me logo Genes that share disorders with FEZF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FEZF2 Gene

Publications for FEZF2 Gene

  1. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. (PMID: 25319688) Berberoglu M.A. … Guo S. (J. Neurosci. 2014) 67
  2. Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system. (PMID: 24913420) Eckler M.J. … Chen B. (Bioessays 2014) 67
  3. Directed differentiation of human embryonic stem cells into corticofugal neurons uncovers heterogeneous Fezf2-expressing subpopulations. (PMID: 23826257) Kmet M. … Chen B. (PLoS ONE 2013) 67
  4. FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma. (PMID: 23677067) Shu X.S. … Tao Q. (Carcinogenesis 2013) 67
  5. Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis. (PMID: 21220648) Daoud H. … Rouleau G.A. (Arch. Neurol. 2011) 67

Products for FEZF2 Gene

Sources for FEZF2 Gene

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