Aliases for FEZF1 Gene
External Ids for FEZF1 Gene
Previous HGNC Symbols for FEZF1 Gene
Previous GeneCards Identifiers for FEZF1 Gene
This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
GeneCards Summary for FEZF1 Gene
FEZF1 (FEZ Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with FEZF1 include Hypogonadotropic Hypogonadism With Or Without Anosmia and Uterine Inversion. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is GFI1.
UniProtKB/Swiss-Prot for FEZF1 Gene
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).