Aliases for FEZ2 Gene
Aliases for FEZ2 Gene
External Ids for FEZ2 Gene
- HGNC: 3660
- Entrez Gene: 9637
- Ensembl: ENSG00000171055
- OMIM: 604826
- UniProtKB: Q9UHY8
Previous GeneCards Identifiers for FEZ2 Gene
- GC02M036744
- GC02M036926
- GC02M036753
- GC02M036691
- GC02M036632
- GC02M036775
Summaries for FEZ2 Gene
-
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
GeneCards Summary for FEZ2 Gene
FEZ2 (Fasciculation And Elongation Protein Zeta 2) is a Protein Coding gene. An important paralog of this gene is FEZ1.
UniProtKB/Swiss-Prot for FEZ2 Gene
-
Involved in axonal outgrowth and fasciculation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZ2 Gene
Genomics for FEZ2 Gene
Regulatory Elements for FEZ2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G036555 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 29.6 | +82.8 | 82756 | 16.4 | PKNOX1 SIN3A ZNF121 ZNF766 GATA2 ZNF143 FOS REST SMARCA4 STAT3 | FEZ2 CRIM1 GC02M036589 GC02P036523 |
| GH02G036553 | 1.1 | Ensembl ENCODE dbSUPER | 29.3 | +92.2 | 92173 | 1.0 | CTCF ZNF654 ZNF384 REST RAD21 JUND POLR2A SMC3 | FEZ2 GC02P036523 GC02M036589 |
| GH02G036545 | 0.7 | dbSUPER | 32.5 | +101.0 | 101004 | 3.3 | CTCF ESRRA CBX3 RB1 CHD7 RAD21 TEAD3 SMC3 PRDM10 CREM | FEZ2 GC02P036523 GC02M036589 |
| GH02G036544 | 0.7 | dbSUPER | 32.5 | +101.1 | 101063 | 2.6 | CTCF ESRRA CBX3 RB1 CHD7 RAD21 TEAD3 SMC3 PRDM10 CREM | FEZ2 GC02P036523 GC02M036589 |
| GH02G036543 | 0.7 | dbSUPER | 32.5 | +101.1 | 101062 | 2.5 | CTCF ESRRA CBX3 RB1 CHD7 RAD21 TEAD3 SMC3 PRDM10 CREM | FEZ2 GC02P036523 GC02M036589 |
Regulatory Element Products
Genomic Location for FEZ2 Gene
- Chromosome:
- 2
- Start:
- 36,531,805 bp from pter
- End:
- 36,646,087 bp from pter
- Size:
- 114,283 bases
- Orientation:
- Minus strand
Genomic View for FEZ2 Gene
- Cytogenetic band:
-
- 2p22.2 by Ensembl
- 2p22.2 by Entrez Gene
- 2p22.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FEZ2 Gene
Proteins for FEZ2 Gene
-
Protein details for FEZ2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHY8-FEZ2_HUMAN
- Recommended name:
- Fasciculation and elongation protein zeta-2
- Protein Accession:
- Q9UHY8
- Q5EBN3
- Q76LN0
- Q99690
Protein attributes for FEZ2 Gene
- Size:
- 353 amino acids
- Molecular mass:
- 39666 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.
- SequenceCaution:
-
- Sequence=AAF14865.1; Type=Frameshift; Positions=41, 51, 71, 78, 84; Evidence={ECO:0000305};
Protein Expression for FEZ2 Gene
Post-translational modifications for FEZ2 Gene
Other Protein References for FEZ2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FEZ2
-
Custom Antibody ServicesOriGene Antibodies for FEZ2
- Novus Biologicals Antibodies for FEZ2
-
Abcam antibodies for FEZ2
- Invitrogen Antibodies for FEZ2
- antibodies-online Antibodies for FEZ2: See all 57
- GeneTex FEZ2 antibody for FEZ2
-
Custom Antibody ServicesProSci Antibodies for FEZ2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FEZ2
Protein Products
-
OriGene Purified Proteins for FEZ2
- Search Origene for MassSpec and Protein Over-expression Lysates for FEZ2
- Origene Custom Protein Services for FEZ2
- Search GeneTex for Proteins for FEZ2
Assay Products
No data available for DME Specific Peptides for FEZ2 Gene
Domains & Families for FEZ2 Gene
Suggested Antigen Peptide Sequences for FEZ2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHY8- Family:
-
- Belongs to the zygin family.
No data available for Gene Families for FEZ2 Gene
Function for FEZ2 Gene
Molecular function for FEZ2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in axonal outgrowth and fasciculation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14690447 |
Phenotypes for FEZ2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FEZ2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZ2 gene
- Search ViGene Biosciences for FEZ2
CRISPR Products
-
OriGene CRISPR knockouts for FEZ2
-
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- GenScript: Design CRISPR guide RNA sequences for FEZ2
miRNA for FEZ2 Gene
- miRTarBase miRNAs that target FEZ2
-
- hsa-mir-17-5p (MIRT159398)
- hsa-mir-20a-5p (MIRT159399)
- hsa-mir-93-5p (MIRT159400)
- hsa-mir-106b-5p (MIRT159405)
- hsa-mir-20b-5p (MIRT159408)
- hsa-mir-519d-3p (MIRT159417)
- hsa-mir-155-5p (MIRT440644)
- hsa-mir-943 (MIRT528025)
- hsa-mir-4439 (MIRT528026)
- hsa-mir-4477a (MIRT528027)
- hsa-mir-3136-5p (MIRT528028)
- hsa-mir-3682-5p (MIRT528029)
- hsa-mir-302a-5p (MIRT528030)
- hsa-mir-634 (MIRT528031)
- hsa-mir-4282 (MIRT528032)
miRNA Products
- Search ViGene Biosciences for FEZ2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEZ2
- Browse OriGene Inhibitory RNA Products For FEZ2
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZ2 gene
Cell Line Products
-
Horizon Cell Lines for FEZ2
-
ViGene Biosciences adenoviral particle packaged cDNA for FEZ2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FEZ2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEZ2 Gene
Localization for FEZ2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0030424 | axon | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FEZ2 Gene
Pathways & Interactions for FEZ2 Gene
Interacting Proteins for FEZ2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 9096408 |
| GO:0007399 | nervous system development | TAS | 9096408 |
| GO:0007411 | axon guidance | TAS | 9096408 |
| GO:1902902 | negative regulation of autophagosome assembly | IMP | 25495476 |
No data available for Pathways by source and SIGNOR curated interactions for FEZ2 Gene
Transcripts for FEZ2 Gene
mRNA/cDNA for FEZ2 Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (334) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FEZ2 Gene
- Fasciculation and elongation protein zeta 2 (zygin II):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FEZ2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEZ2
- GenScript: Design CRISPR guide RNA sequences for FEZ2
miRNA Products
- Search ViGene Biosciences for FEZ2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEZ2
- Browse OriGene Inhibitory RNA Products For FEZ2
-
ViGene Biosciences ready-to-package AAV shRNAs for FEZ2 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for FEZ2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Horizontal Cells Inner Nuclear Layer
-
Neurons
- Mature Horizontal Cells Inner Nuclear Layer
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Gonad
- Primordial Germ Cell Precursors Epiblast
- Brain (Nervous System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for FEZ2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEZ2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FEZ2 Gene:
FEZ2SOURCE GeneReport for Unigene cluster for FEZ2 Gene:
Hs.258563mRNA Expression by UniProt/SwissProt for FEZ2 Gene:
Q9UHY8-FEZ2_HUMANEvidence on tissue expression from TISSUES for FEZ2 Gene
- Adrenal gland(4.3)
- Liver(4.3)
- Nervous system(3.4)
- Muscle(3.2)
Primer Products
-
OriGene qPCR primer pairs for FEZ2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FEZ2 Gene
Orthologs for FEZ2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FEZ2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FEZ2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FEZ2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fez2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FEZ2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fez2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FEZ2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FEZ2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FEZ2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fez2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-288i20.2 34 |
|
||
| FEZ2 (1 of 2) 35 |
|
OneToMany | |||
| FEZ2 (2 of 2) 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Unc-76 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003014 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-76 36 34 35 |
|
- Species where no ortholog for FEZ2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FEZ2 Gene
(2) SIMAP similar genes for FEZ2 Gene using alignment to 11 proteins:
Variants for FEZ2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030893 | -- | 36,555,302(+) | TCACT(A/C)ATGAT | intron-variant | |
| rs1000055876 | -- | 36,572,834(+) | CATGA(C/G)CTGAG | intron-variant | |
| rs1000105948 | -- | 36,566,045(+) | TGAAA(C/T)TGGTT | intron-variant | |
| rs1000185615 | -- | 36,577,901(+) | CTTTA(C/G)CCAAC | intron-variant | |
| rs1000242401 | -- | 36,558,742(+) | AAACA(A/G)CCACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2662106 | CNV | deletion | 23128226 |
| esv2719923 | CNV | deletion | 23290073 |
| esv3590394 | CNV | loss | 21293372 |
| esv3590395 | CNV | loss | 21293372 |
| esv3590396 | CNV | loss | 21293372 |
| nsv1071587 | CNV | deletion | 25765185 |
| nsv1121998 | CNV | deletion | 24896259 |
| nsv2681 | CNV | deletion | 18451855 |
Relevant External Links for FEZ2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FEZ2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEZ2 Gene
Disorders for FEZ2 Gene
Relevant External Links for FEZ2
No disorders were found for FEZ2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEZ2 Gene
Publications for FEZ2 Gene
- Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. (PMID: 14697253) Fujita T. … Kuroda S. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
- The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PMID: 9096408) Bloom L. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 64
- Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann E.M. … Kobarg J. (J. Biol. Chem. 2006) 3 4 64
Products for FEZ2 Gene
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- Custom Antibody ServicesOriGene Antibodies for FEZ2
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- Novus Biologicals Antibodies for FEZ2
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- Novus Biologicals
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- ViGene Biosciences adenoviral particle packaged cDNA for FEZ2 gene
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- Search ViGene Biosciences for FEZ2
- Santa Cruz Biotechnology (SCBT) Antibodies for FEZ2
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FEZ2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




