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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FEZ2 Gene

protein-coding   GIFtS: 56
GCID: GC02M036775

Fasciculation And Elongation Protein Zeta 2 (Zygin II)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fasciculation And Elongation Protein Zeta 2 (Zygin II)1 2     Pre-T/NK Cell Associated Protein (3Cl)2
Zygin II2 3     Zygin 22
HUM3CL2     zygin-22
Fasciculation And Elongation Protein Zeta-22     Zygin-23

External Ids:    HGNC: 36601   Entrez Gene: 96372   Ensembl: ENSG000001710557   OMIM: 6048265   UniProtKB: Q9UHY83   

Export aliases for FEZ2 gene to outside databases

Previous GC identifers: GC02M036744 GC02M036926 GC02M036753 GC02M036691 GC02M036632 GC02M036519


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FEZ2 Gene:
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and
elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to
synaptotagmin. (provided by RefSeq, Jul 2008)

GeneCards Summary for FEZ2 Gene: 
FEZ2 (fasciculation and elongation protein zeta 2 (zygin II)) is a protein-coding gene. Diseases associated with FEZ2 include kidney disease, and polycystic kidney disease. GO annotations related to this gene include protein binding. An important paralog of this gene is FEZ1.

UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8
Function: Involved in axonal outgrowth and fasciculation (By similarity)

Gene Wiki entry for FEZ2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FEZ2 gene promoter:
         HOXA9B   HOXA9   Sox5   AP-1   Nkx2-5   STAT5A   Meis-1b   HFH-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFEZ2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FEZ2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p21

FEZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEZ2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M036775:  view genomic region     (about GC identifiers)

Start:
36,778,570 bp from pter      End:
36,873,230 bp from pter
Size:
94,661 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8 (See protein sequence)
Recommended Name: Fasciculation and elongation protein zeta-2  
Size: 353 amino acids; 39666 Da
Subunit: Homodimer; difulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin
Sequence caution: Sequence=AAF14865.1; Type=Frameshift; Positions=41, 51, 71, 78, 84;
Secondary accessions: Q5EBN3 Q76LN0 Q99690
Alternative splicing: 2 isoforms:  Q9UHY8-1   Q9UHY8-2   

Explore the universe of human proteins at neXtProt for FEZ2: NX_Q9UHY8

Explore proteomics data for FEZ2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHY8

  • FEZ2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FEZ2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001036013.1  NP_005093.2  

    ENSEMBL proteins: 
     ENSP00000395619   ENSP00000415325   ENSP00000410879   ENSP00000368547   ENSP00000385112  
     ENSP00000390985   ENSP00000396982   ENSP00000350685   ENSP00000305843  

    Human Recombinant Protein Products for FEZ2: 
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    Novus Biologicals FEZ2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


    FEZ2 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR011680 FEZ

    Graphical View of Domain Structure for InterPro Entry Q9UHY8

    ProtoNet protein and cluster: Q9UHY8

    1 Blocks protein domain: IPB011680 FEZ-like

    UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8
    Similarity: Belongs to the zygin family


    FEZ2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEZ2_HUMAN, Q9UHY8
    Function: Involved in axonal outgrowth and fasciculation (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14690447
         
    FEZ2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FEZ2:
     Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FEZ2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FEZ2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FEZ2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FEZ2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FEZ2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate FEZ2 (see all 11):
    hsa-miR-148b hsa-miR-429 hsa-miR-1257 hsa-miR-374c hsa-miR-152 hsa-miR-200c hsa-miR-655 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidFEZ2 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of FEZ2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FEZ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for FEZ2 (Q9UHY81, 3 ENSP000003685474) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK1Q96PY61, 3, ENSP000004080204EBI-396453,EBI-373615 I2D: score=4 STRING: ENSP00000408020
    PRKCZQ055133, ENSP000003678304I2D: score=3 STRING: ENSP00000367830
    FEZ1Q996893, ENSP000002789194I2D: score=2 STRING: ENSP00000278919
    BRD1O956963, ENSP000002162674I2D: score=1 STRING: ENSP00000216267
    C16orf59Q7L2K03, ENSP000003550224I2D: score=1 STRING: ENSP00000355022
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9096408
    GO:0007399nervous system development TAS9096408
    GO:0007411axon guidance TAS9096408

    FEZ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FEZ2

    Search CenterWatch for drugs/clinical trials and news about FEZ2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FEZ2 gene (2 alternative transcripts): 
    NM_001042548.1  NM_005102.2  

    Unigene Cluster for FEZ2:

    Fasciculation and elongation protein zeta 2 (zygin II)
    Hs.258563  [show with all ESTs]
    Unigene Representative Sequence: NM_001042548
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414288 ENST00000475815 ENST00000441005 ENST00000413938(uc002rpf.2)
    ENST00000379245(uc002rpg.2 uc002rph.2 uc002rpj.2) ENST00000405912
    ENST00000451623 ENST00000432869 ENST00000487919 ENST00000487282 ENST00000484205
    ENST00000464964 ENST00000357996 ENST00000305852
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FEZ2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate FEZ2 (see all 11):
    hsa-miR-148b hsa-miR-429 hsa-miR-1257 hsa-miR-374c hsa-miR-152 hsa-miR-200c hsa-miR-655 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidFEZ2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEZ2
    Sirion Biotech Customized lentivirus for stable overexpression of FEZ2 
                         Customized lentivirus expression plasmids for stable overexpression of FEZ2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FEZ2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEZ2

    Additional mRNA sequence: 

    AB076184.1 AB209719.1 AF113124.1 AK025274.1 AK057492.1 BC018032.1 BC037566.1 BC047020.1 
    BC054043.1 BC064484.1 BC089390.1 BC110386.1 BX537785.1 U60061.1 U69140.1 

    19 DOTS entries:

    DT.99981840  DT.446810  DT.101983959  DT.100825793  DT.86855362  DT.120959894  DT.95177598  DT.120959979 
    DT.75195443  DT.120959888  DT.86855361  DT.92446854  DT.95177596  DT.120959855  DT.120959915  DT.92446860 
    DT.120959876  DT.120959912  DT.92446858 

    24/334 AceView cDNA sequences (see all 334):

    BC064484 R30727 BU633824 BQ003912 F26373 AW001010 CD722314 AI371012 
    BX474601 T30303 AI631947 BM680200 AW471489 CB305818 AW241341 F26364 
    AW502123 AI796411 CB265919 CR589976 AA442708 AW594135 AA043279 CR618629 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FEZ2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                              -           -                 -                     
    SP2:        -                       -                                                                                 
    SP3:                                -                                                                                 
    SP4:                                                                                                                  
    SP5:                                                              -     -     -     -           -                     


    ECgene alternative splicing isoforms for FEZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FEZ2 expression in normal human tissues (normalized intensities)      FEZ2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACTTTTG
    FEZ2 Expression
    About this image


    FEZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer

    See FEZ2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FEZ2

    SOURCE GeneReport for Unigene cluster: Hs.258563

    UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8
    Tissue specificity: Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and
    melanocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FEZ2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fez21 , 5 fasciculation and elongation protein zeta 2 (zygin more1, 5 85.92(n)1
    90.8(a)1
      17 (48.57 cM)5
    2250201  NM_199448.21  NP_955519.11 
     783778855 
    chicken
    (Gallus gallus)
    Aves FEZ21 fasciculation and elongation protein zeta 2 (zygin more 79.07(n)
    84.45(a)
      421472  XM_419521.3  XP_419521.3 
    lizard
    (Anolis carolinensis)
    Reptilia FEZ26
    Uncharacterized protein
    86(a)
    1 ↔ 1
    AAWZ02036584(9935-21825)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL865716.22   -- 78.51(n)    AL865716.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-57i17.11 si:ch211-57i17.1 60.18(n)
    60.79(a)
      565010  NM_001077432.1  NP_001070900.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-761 CG3981-PA 52.55(n)
    43.42(a)
      31179  NM_166927.1  NP_726792.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-761 , 3 UNC-76 protein3
    Protein UNC-761
    34(a)3
    47.77(n)1
    37.68(a)1
      V(15074458-15082307)3
    1800141  NM_074311.31  NP_506712.41 


    ENSEMBL Gene Tree for FEZ2 (if available)
    TreeFam Gene Tree for FEZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FEZ2 gene
    FEZ12  
    2 SIMAP similar genes for FEZ2 using alignment to 11 protein entries:     FEZ2_HUMAN (see all proteins):
    DKFZp779C2259    FEZ1

    FEZ2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1297 SNPs in FEZ2 are shown (see all 1297)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580675081,2
    C,F--36778931(+) TCTCAT/CACCCC 2 -- ds50011Minor allele frequency- C:0.05EA 120
    rs757008251,2
    F--36778983(+) AACCGC/TGCCCC 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1149574571,2
    F--36779130(+) ATGTCG/ATCTAT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs101807601,2
    C,F,A,H--36779144(+) AGGGGT/GCTGCA 2 -- ds500119Minor allele frequency- G:0.49NS EA WA NA 2338
    rs1411807901,2
    --36779230(+) TACTCC/TAATAA 2 -- ds50010--------
    rs1451421071,2
    --36779238(+) TAAACA/GTCCTC 2 -- ds50010--------
    rs1895773211,2
    C--36779277(+) AATCAG/CGGTTT 2 -- ds50011Minor allele frequency- C:0.00EU 593
    rs779169971,2
    C,F--36779297(+) ACATAT/CTGTAG 2 -- ds50011Minor allele frequency- C:0.04EA 120
    rs126124741,2
    C,F,H--36779312(+) GGGTTC/GTGTGT 2 -- ds50011Minor allele frequency- G:0.33NA 6
    rs1926050091,2
    --36779373(+) AAAACC/TCCCAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for FEZ2 (36778570 - 36873230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FEZ2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662106CNV Deletion23128226
    esv2719923CNV Deletion23290073
    nsv2681CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604826    OMIM disorders: --

    2 diseases for FEZ2:    About MalaCards
    kidney disease    polycystic kidney disease


    FEZ2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FEZ2
    Human Genome Epidemiology (HuGE) Navigator: FEZ2 (2 documents)

    Export disorders for FEZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FEZ2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with FEZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PubMed id 9096408)1, 2, 3 Bloom L. and Horvitz H.R. (1997)
    2. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. (PubMed id 14697253)1, 2, 9 Fujita T....Kuroda S. (2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    5. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2 Assmann E.M.... Kobarg J. (2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9637 HGNC: 3660 AceView: FEZ2 Ensembl:ENSG00000171055 euGenes: HUgn9637
    ECgene: FEZ2 H-InvDB: FEZ2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FEZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FEZ2 gene:
    Search GeneIP for patents involving FEZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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