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Aliases for FEZ2 Gene

Aliases for FEZ2 Gene

  • Fasciculation And Elongation Protein Zeta 2 (Zygin II) 2 3
  • Zygin II 3 4
  • Zygin-2 3 4
  • Fasciculation And Elongation Protein Zeta-2 3
  • Pre-T/NK Cell Associated Protein (3Cl) 3
  • Zygin 2 3
  • HUM3CL 3

External Ids for FEZ2 Gene

Previous GeneCards Identifiers for FEZ2 Gene

  • GC02M036744
  • GC02M036926
  • GC02M036753
  • GC02M036691
  • GC02M036632
  • GC02M036775

Summaries for FEZ2 Gene

Entrez Gene Summary for FEZ2 Gene

  • This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEZ2 Gene

FEZ2 (Fasciculation And Elongation Protein Zeta 2 (Zygin II)) is a Protein Coding gene. An important paralog of this gene is FEZ1.

UniProtKB/Swiss-Prot for FEZ2 Gene

  • Involved in axonal outgrowth and fasciculation.

Gene Wiki entry for FEZ2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZ2 Gene

Genomics for FEZ2 Gene

Regulatory Elements for FEZ2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FEZ2 Gene

36,531,805 bp from pter
36,646,087 bp from pter
114,283 bases
Minus strand

Genomic View for FEZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FEZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEZ2 Gene

Proteins for FEZ2 Gene

  • Protein details for FEZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fasciculation and elongation protein zeta-2
    Protein Accession:
    Secondary Accessions:
    • Q5EBN3
    • Q76LN0
    • Q99690

    Protein attributes for FEZ2 Gene

    353 amino acids
    Molecular mass:
    39666 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.
    • Sequence=AAF14865.1; Type=Frameshift; Positions=41, 51, 71, 78, 84; Evidence={ECO:0000305};

    Alternative splice isoforms for FEZ2 Gene


neXtProt entry for FEZ2 Gene

Proteomics data for FEZ2 Gene at MOPED

Post-translational modifications for FEZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for FEZ2 Gene

Domains for FEZ2 Gene

Protein Domains for FEZ2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zygin family.
  • Belongs to the zygin family.
genes like me logo Genes that share domains with FEZ2: view

No data available for Gene Families for FEZ2 Gene

Function for FEZ2 Gene

Molecular function for FEZ2 Gene

UniProtKB/Swiss-Prot Function:
Involved in axonal outgrowth and fasciculation.

Gene Ontology (GO) - Molecular Function for FEZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14690447
genes like me logo Genes that share ontologies with FEZ2: view

Phenotypes for FEZ2 Gene

genes like me logo Genes that share phenotypes with FEZ2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FEZ2 Gene

Localization for FEZ2 Gene

Subcellular locations from

Jensen Localization Image for FEZ2 Gene COMPARTMENTS Subcellular localization image for FEZ2 gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FEZ2 Gene

Pathways for FEZ2 Gene

SuperPathways for FEZ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FEZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9096408
GO:0007399 nervous system development TAS 9096408
GO:0007411 axon guidance TAS 9096408
genes like me logo Genes that share ontologies with FEZ2: view

No data available for Pathways by source for FEZ2 Gene

Transcripts for FEZ2 Gene

Unigene Clusters for FEZ2 Gene

Fasciculation and elongation protein zeta 2 (zygin II):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FEZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: -
SP5: - - - - -
SP6: -
SP8: -

Relevant External Links for FEZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEZ2 Gene

mRNA expression in normal human tissues for FEZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEZ2 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Protein differential expression in normal tissues for FEZ2 Gene

This gene is overexpressed in Heart (24.0), Placenta (19.7), Ovary (9.7), and Spleen (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FEZ2 Gene

SOURCE GeneReport for Unigene cluster for FEZ2 Gene Hs.258563

mRNA Expression by UniProt/SwissProt for FEZ2 Gene

Tissue specificity: Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes
genes like me logo Genes that share expressions with FEZ2: view

Expression partners for FEZ2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for FEZ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FEZ2 35
  • 90.69 (n)
  • 94.68 (a)
FEZ2 36
  • 96 (a)
(Canis familiaris)
Mammalia FEZ2 35
  • 91.49 (n)
  • 94.41 (a)
FEZ2 36
  • 96 (a)
(Mus musculus)
Mammalia Fez2 35
  • 86.31 (n)
  • 90.67 (a)
Fez2 16
Fez2 36
  • 89 (a)
(Pan troglodytes)
Mammalia FEZ2 35
  • 96.56 (n)
  • 94.99 (a)
FEZ2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fez2 35
  • 88.44 (n)
  • 91.73 (a)
(Monodelphis domestica)
Mammalia FEZ2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FEZ2 36
  • 86 (a)
(Gallus gallus)
Aves FEZ2 35
  • 79.72 (n)
  • 84.23 (a)
FEZ2 36
  • 80 (a)
(Anolis carolinensis)
Reptilia FEZ2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fez2 35
  • 72.14 (n)
  • 72.33 (a)
(Danio rerio)
Actinopterygii si:dkey-288i20.2 35
  • 61.94 (n)
  • 59.44 (a)
FEZ2 (1 of 2) 36
  • 55 (a)
FEZ2 (2 of 2) 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003014 35
  • 52.3 (n)
  • 45.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Unc-76 35
  • 53.86 (n)
  • 46.38 (a)
Unc-76 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea unc-76 37
  • 34 (a)
unc-76 35
  • 47.57 (n)
  • 38.69 (a)
unc-76 36
  • 27 (a)
Species with no ortholog for FEZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEZ2 Gene

Gene Tree for FEZ2 (if available)
Gene Tree for FEZ2 (if available)

Paralogs for FEZ2 Gene

Paralogs for FEZ2 Gene

genes like me logo Genes that share paralogs with FEZ2: view

Variants for FEZ2 Gene

Sequence variations from dbSNP and Humsavar for FEZ2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14291 -- 36,583,443(-) GATAC(A/G)TCAGA reference, synonymous-codon, nc-transcript-variant
rs16700 -- 36,590,025(-) GAAAA(-/AA)TCACA intron-variant
rs848609 -- 36,589,285(-) GCCTT(A/G)CTGTC intron-variant
rs848610 -- 36,589,116(-) TAAGT(A/T)TGAAG intron-variant
rs848611 -- 36,588,884(-) GAGAC(A/G)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEZ2 Gene

Variant ID Type Subtype PubMed ID
esv2719923 CNV Deletion 23290073
esv2662106 CNV Deletion 23128226
nsv2681 CNV Loss 18451855

Relevant External Links for FEZ2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEZ2 Gene

Disorders for FEZ2 Gene

Relevant External Links for FEZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FEZ2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FEZ2 Gene

Publications for FEZ2 Gene

  1. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. (PMID: 14697253) Fujita T. … Kuroda S. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PMID: 9096408) Bloom L. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann E.M. … Kobarg J. (J. Biol. Chem. 2006) 3 4

Products for FEZ2 Gene

Sources for FEZ2 Gene

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