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Aliases for FEZ2 Gene

Aliases for FEZ2 Gene

  • Fasciculation And Elongation Protein Zeta 2 2 3
  • Zygin II 2 3 4
  • Fasciculation And Elongation Protein Zeta 2 (Zygin II) 3 5
  • Zygin-2 3 4
  • Pre-T/NK Cell Associated Protein (3Cl) 3
  • Zygin 2 3
  • HUM3CL 3

External Ids for FEZ2 Gene

Previous GeneCards Identifiers for FEZ2 Gene

  • GC02M036744
  • GC02M036926
  • GC02M036753
  • GC02M036691
  • GC02M036632
  • GC02M036775

Summaries for FEZ2 Gene

Entrez Gene Summary for FEZ2 Gene

  • This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEZ2 Gene

FEZ2 (Fasciculation And Elongation Protein Zeta 2) is a Protein Coding gene. An important paralog of this gene is FEZ1.

UniProtKB/Swiss-Prot for FEZ2 Gene

  • Involved in axonal outgrowth and fasciculation.

Gene Wiki entry for FEZ2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZ2 Gene

Genomics for FEZ2 Gene

Regulatory Elements for FEZ2 Gene

Genomic Location for FEZ2 Gene

Chromosome:
2
Start:
36,531,805 bp from pter
End:
36,646,087 bp from pter
Size:
114,283 bases
Orientation:
Minus strand

Genomic View for FEZ2 Gene

Genes around FEZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEZ2 Gene

Proteins for FEZ2 Gene

  • Protein details for FEZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHY8-FEZ2_HUMAN
    Recommended name:
    Fasciculation and elongation protein zeta-2
    Protein Accession:
    Q9UHY8
    Secondary Accessions:
    • Q5EBN3
    • Q76LN0
    • Q99690

    Protein attributes for FEZ2 Gene

    Size:
    353 amino acids
    Molecular mass:
    39666 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.
    SequenceCaution:
    • Sequence=AAF14865.1; Type=Frameshift; Positions=41, 51, 71, 78, 84; Evidence={ECO:0000305};

    Alternative splice isoforms for FEZ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FEZ2 Gene

Proteomics data for FEZ2 Gene at MOPED

Post-translational modifications for FEZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for FEZ2 Gene

Domains & Families for FEZ2 Gene

Protein Domains for FEZ2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UHY8

UniProtKB/Swiss-Prot:

FEZ2_HUMAN :
  • Belongs to the zygin family.
Family:
  • Belongs to the zygin family.
genes like me logo Genes that share domains with FEZ2: view

No data available for Gene Families for FEZ2 Gene

Function for FEZ2 Gene

Molecular function for FEZ2 Gene

UniProtKB/Swiss-Prot Function:
Involved in axonal outgrowth and fasciculation.
genes like me logo Genes that share phenotypes with FEZ2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEZ2 Gene

Localization for FEZ2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FEZ2 Gene COMPARTMENTS Subcellular localization image for FEZ2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FEZ2 Gene

Pathways & Interactions for FEZ2 Gene

SuperPathways for FEZ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FEZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9096408
GO:1902902 negative regulation of autophagosome assembly IMP 25495476
genes like me logo Genes that share ontologies with FEZ2: view

No data available for Pathways by source and SIGNOR curated interactions for FEZ2 Gene

Drugs & Compounds for FEZ2 Gene

No Compound Related Data Available

Transcripts for FEZ2 Gene

Unigene Clusters for FEZ2 Gene

Fasciculation and elongation protein zeta 2 (zygin II):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FEZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: - - - - -
SP6: -
SP7:
SP8: -

Relevant External Links for FEZ2 Gene

GeneLoc Exon Structure for
FEZ2
ECgene alternative splicing isoforms for
FEZ2

Expression for FEZ2 Gene

mRNA expression in normal human tissues for FEZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEZ2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for FEZ2 Gene

This gene is overexpressed in Heart (24.0), Placenta (19.7), Ovary (9.7), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FEZ2 Gene



SOURCE GeneReport for Unigene cluster for FEZ2 Gene Hs.258563

mRNA Expression by UniProt/SwissProt for FEZ2 Gene

Q9UHY8-FEZ2_HUMAN
Tissue specificity: Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.
genes like me logo Genes that share expression patterns with FEZ2: view

Protein tissue co-expression partners for FEZ2 Gene

Primer Products

In Situ Assay Products

Orthologs for FEZ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZ2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEZ2 36
  • 100 (a)
OneToOne
FEZ2 35
  • 96.56 (n)
  • 94.99 (a)
cow
(Bos Taurus)
Mammalia FEZ2 35
  • 90.69 (n)
  • 94.68 (a)
FEZ2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FEZ2 36
  • 96 (a)
OneToOne
FEZ2 35
  • 91.49 (n)
  • 94.41 (a)
mouse
(Mus musculus)
Mammalia Fez2 36
  • 89 (a)
OneToOne
Fez2 16
Fez2 35
  • 86.31 (n)
  • 90.67 (a)
oppossum
(Monodelphis domestica)
Mammalia FEZ2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FEZ2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fez2 35
  • 88.44 (n)
  • 91.73 (a)
chicken
(Gallus gallus)
Aves FEZ2 35
  • 79.72 (n)
  • 84.23 (a)
FEZ2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FEZ2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fez2 35
  • 72.14 (n)
  • 72.33 (a)
zebrafish
(Danio rerio)
Actinopterygii FEZ2 (1 of 2) 36
  • 55 (a)
OneToMany
FEZ2 (2 of 2) 36
  • 54 (a)
OneToMany
si:dkey-288i20.2 35
  • 61.94 (n)
  • 59.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003014 35
  • 52.3 (n)
  • 45.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Unc-76 36
  • 25 (a)
OneToMany
Unc-76 35
  • 53.86 (n)
  • 46.38 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-76 35
  • 47.57 (n)
  • 38.69 (a)
unc-76 37
  • 34 (a)
unc-76 36
  • 27 (a)
OneToMany
Species with no ortholog for FEZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEZ2 Gene

ENSEMBL:
Gene Tree for FEZ2 (if available)
TreeFam:
Gene Tree for FEZ2 (if available)

Paralogs for FEZ2 Gene

Paralogs for FEZ2 Gene

genes like me logo Genes that share paralogs with FEZ2: view

Variants for FEZ2 Gene

Sequence variations from dbSNP and Humsavar for FEZ2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs848616 -- 36,584,324(-) TGGGC(A/G)TGAAG intron-variant
rs848617 -- 36,584,155(-) ACCTT(C/G)CAGTC intron-variant
rs848618 -- 36,583,732(-) AATAC(A/C)GTATT intron-variant
rs848619 -- 36,583,626(-) AATAT(A/G)TACTC intron-variant
rs848639 -- 36,580,792(-) TACCT(C/G)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEZ2 Gene

Variant ID Type Subtype PubMed ID
esv2719923 CNV Deletion 23290073
esv2662106 CNV Deletion 23128226
nsv2681 CNV Loss 18451855

Variation tolerance for FEZ2 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEZ2 Gene

HapMap Linkage Disequilibrium report
FEZ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEZ2 Gene

Disorders for FEZ2 Gene

Relevant External Links for FEZ2

Genetic Association Database (GAD)
FEZ2
Human Genome Epidemiology (HuGE) Navigator
FEZ2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FEZ2

No disorders were found for FEZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEZ2 Gene

Publications for FEZ2 Gene

  1. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PMID: 9096408) Bloom L. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 67
  2. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. (PMID: 14697253) Fujita T. … Kuroda S. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. (PMID: 25495476) Spang N. … Behl C. (Autophagy 2014) 3

Products for FEZ2 Gene

Sources for FEZ2 Gene

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