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FEZ2 Gene

protein-coding   GIFtS: 55
GCID: GC02M036775

Fasciculation And Elongation Protein Zeta 2 (Zygin II)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fasciculation And Elongation Protein Zeta 2 (Zygin II)1 2     Pre-T/NK Cell Associated Protein (3Cl)2
Zygin II2 3     Zygin 22
HUM3CL2     zygin-22
Fasciculation And Elongation Protein Zeta-22     Zygin-23

External Ids:    HGNC: 36601   Entrez Gene: 96372   Ensembl: ENSG000001710557   OMIM: 6048265   UniProtKB: Q9UHY83   

Export aliases for FEZ2 gene to outside databases

Previous GC identifers: GC02M036744 GC02M036926 GC02M036753 GC02M036691 GC02M036632 GC02M036519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FEZ2 Gene:
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and
elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to
synaptotagmin. (provided by RefSeq, Jul 2008)

GeneCards Summary for FEZ2 Gene:
FEZ2 (fasciculation and elongation protein zeta 2 (zygin II)) is a protein-coding gene. An important paralog of this gene is FEZ1.

UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8
Function: Involved in axonal outgrowth and fasciculation (By similarity)

Gene Wiki entry for FEZ2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FEZ2 gene promoter:
         HOXA9B   HOXA9   Sox5   AP-1   Nkx2-5   STAT5A   Meis-1b   HFH-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFEZ2 promoter sequence
   Search Chromatin IP Primers for FEZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FEZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p21

FEZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEZ2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M036775:  view genomic region     (about GC identifiers)

Start:
36,778,570 bp from pter      End:
36,873,230 bp from pter
Size:
94,661 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8 (See protein sequence)
Recommended Name: Fasciculation and elongation protein zeta-2  
Size: 353 amino acids; 39666 Da
Subunit: Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin
Sequence caution: Sequence=AAF14865.1; Type=Frameshift; Positions=41, 51, 71, 78, 84;
Secondary accessions: Q5EBN3 Q76LN0 Q99690
Alternative splicing: 2 isoforms:  Q9UHY8-1   Q9UHY8-2   

Explore the universe of human proteins at neXtProt for FEZ2: NX_Q9UHY8

Explore proteomics data for FEZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FEZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036013.1  NP_005093.2  

    ENSEMBL proteins: 
     ENSP00000395619   ENSP00000415325   ENSP00000410879   ENSP00000368547   ENSP00000385112  
     ENSP00000390985   ENSP00000396982   ENSP00000350685   ENSP00000305843  

    FEZ2 Human Recombinant Protein Products:

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    Novus Biologicals FEZ2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FEZ2 

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    Search eBioscience for ELISAs for FEZ2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015641 FEZ_2
     IPR011680 FEZ

    Graphical View of Domain Structure for InterPro Entry Q9UHY8

    ProtoNet protein and cluster: Q9UHY8

    1 Blocks protein domain: IPB011680 FEZ-like

    UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8
    Similarity: Belongs to the zygin family


    Find genes that share domains with FEZ2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEZ2_HUMAN, Q9UHY8
    Function: Involved in axonal outgrowth and fasciculation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14690447
         
    Find genes that share ontologies with FEZ2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FEZ2:
     Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FEZ2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FEZ2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FEZ2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FEZ2

    miRNA
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    Block miRNA regulation of human, mouse, rat FEZ2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FEZ2 (see all 11):
    hsa-miR-148b hsa-miR-429 hsa-miR-1257 hsa-miR-374c hsa-miR-152 hsa-miR-200c hsa-miR-655 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidFEZ2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FEZ2

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    GenScript: all cDNA clones in your preferred vector (see all 2): FEZ2 (NM_005102)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEZ2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FEZ2
    Interactions:

        GeneGlobe Interaction Network for FEZ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for FEZ2 (Q9UHY81, 3 ENSP000003685474) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK1Q96PY61, 3, ENSP000004080204EBI-396453,EBI-373615 I2D: score=4 STRING: ENSP00000408020
    PRKCZQ055133, ENSP000003678304I2D: score=3 STRING: ENSP00000367830
    FEZ1Q996893, ENSP000002789194I2D: score=2 STRING: ENSP00000278919
    BRD1O956963, ENSP000002162674I2D: score=1 STRING: ENSP00000216267
    C16orf59Q7L2K03, ENSP000003550224I2D: score=1 STRING: ENSP00000355022
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9096408
    GO:0007399nervous system development TAS9096408
    GO:0007411axon guidance TAS9096408

    Find genes that share ontologies with FEZ2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FEZ2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FEZ2 gene (2 alternative transcripts): 
    NM_001042548.1  NM_005102.2  

    Unigene Cluster for FEZ2:

    Fasciculation and elongation protein zeta 2 (zygin II)
    Hs.258563  [show with all ESTs]
    Unigene Representative Sequence: NM_001042548
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414288 ENST00000475815 ENST00000441005 ENST00000413938(uc002rpf.2)
    ENST00000379245(uc002rpg.2 uc002rph.2 uc002rpj.2) ENST00000405912
    ENST00000451623 ENST00000432869 ENST00000487919 ENST00000487282 ENST00000484205
    ENST00000464964 ENST00000357996 ENST00000305852
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FEZ2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FEZ2 (see all 11):
    hsa-miR-148b hsa-miR-429 hsa-miR-1257 hsa-miR-374c hsa-miR-152 hsa-miR-200c hsa-miR-655 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidFEZ2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FEZ2
    Predesigned siRNA for gene silencing in human, mouse, rat FEZ2
    Clone
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    OriGene ORF clones in mouse, rat for FEZ2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FEZ2 (NM_005102)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEZ2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FEZ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FEZ2
      QuantiTect SYBR Green Assays in human, mouse, rat FEZ2
      QuantiFast Probe-based Assays in human, mouse, rat FEZ2

    Additional mRNA sequence: 

    AB076184.1 AB209719.1 AF113124.1 AK025274.1 AK057492.1 BC018032.1 BC037566.1 BC047020.1 
    BC054043.1 BC064484.1 BC089390.1 BC110386.1 BX537785.1 U60061.1 U69140.1 

    19 DOTS entries:

    DT.99981840  DT.446810  DT.101983959  DT.100825793  DT.86855362  DT.120959894  DT.95177598  DT.120959979 
    DT.75195443  DT.120959888  DT.86855361  DT.92446854  DT.95177596  DT.120959855  DT.120959915  DT.92446860 
    DT.120959876  DT.120959912  DT.92446858 

    Selected AceView cDNA sequences (see all 334):

    BU633824 AW241341 BM680200 BM669912 AI796411 AW502123 N91936 CR589976 
    AI872762 AI278051 AW204817 CR606546 AA150613 CA443996 AI127405 BU621582 
    AW069721 CK299374 AI311743 CR594110 AA035389 BM726032 W24114 CR591023 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FEZ2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                              -           -                 -                     
    SP2:        -                       -                                                                                 
    SP3:                                -                                                                                 
    SP4:                                                                                                                  
    SP5:                                                              -     -     -     -           -                     


    ECgene alternative splicing isoforms for FEZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FEZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACTTTTG
    FEZ2 Expression
    About this image


    FEZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)
    FEZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FEZ2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258563

    UniProtKB/Swiss-Prot: FEZ2_HUMAN, Q9UHY8
    Tissue specificity: Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and
    melanocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FEZ2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fez21 , 5 fasciculation and elongation protein zeta 2 (zygin more1, 5 86.31(n)1
    90.67(a)1
      17 (48.57 cM)5
    2250201  NM_001285940.11  NP_001272869.11 
     783778855 
    chicken
    (Gallus gallus)
    Aves FEZ21 fasciculation and elongation protein zeta 2 (zygin more 79.72(n)
    84.23(a)
      421472  XM_004935423.1  XP_004935480.1 
    lizard
    (Anolis carolinensis)
    Reptilia FEZ26
    fasciculation and elongation protein zeta 2 (zygin...
    86(a)
    1 ↔ 1
    AAWZ02036584(9935-21825)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL865716.22   -- 78.51(n)    AL865716.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-288i20.21 si:dkey-288i20.2 61.94(n)
    59.44(a)
      100334565  XM_002664769.2  XP_002664815.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-761 Unc-76 53.86(n)
    46.38(a)
      31179  NM_130625.3  NP_569981.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-761 , 3 UNC-76 protein3
    unc-761
    34(a)3
    47.57(n)1
    38.69(a)1
      V(15074458-15082307)3
    1800141  NM_001269716.11  NP_001256645.11 


    ENSEMBL Gene Tree for FEZ2 (if available)
    TreeFam Gene Tree for FEZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FEZ2 gene
    FEZ12  
    2 SIMAP similar genes for FEZ2 using alignment to 11 protein entries:     FEZ2_HUMAN (see all proteins):
    DKFZp779C2259    FEZ1

    Find genes that share paralogs with FEZ2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FEZ2 (see all 1297)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580675081,2
    C,F--36778931(+) TCTCAT/CACCCC 2 -- ds50011Minor allele frequency- C:0.05EA 120
    rs757008251,2
    F--36778983(+) AACCGC/TGCCCC 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1149574571,2
    F--36779130(+) ATGTCG/ATCTAT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs101807601,2
    C,F,A,H--36779144(+) AGGGGT/GCTGCA 2 -- ds500119Minor allele frequency- G:0.49NS EA WA NA 2338
    rs1411807901,2
    --36779230(+) TACTCC/TAATAA 2 -- ds50010--------
    rs1451421071,2
    --36779238(+) TAAACA/GTCCTC 2 -- ds50010--------
    rs1895773211,2
    C--36779277(+) AATCAG/CGGTTT 2 -- ds50011Minor allele frequency- C:0.00EU 593
    rs779169971,2
    C,F--36779297(+) ACATAT/CTGTAG 2 -- ds50011Minor allele frequency- C:0.04EA 120
    rs126124741,2
    C,F,H--36779312(+) GGGTTC/GTGTGT 2 -- ds50011Minor allele frequency- G:0.33NA 6
    rs1926050091,2
    --36779373(+) AAAACC/TCCCAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for FEZ2 (36778570 - 36873230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FEZ2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662106CNV Deletion23128226
    esv2719923CNV Deletion23290073
    nsv2681CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604826    OMIM disorders: --


    Find genes that share disorders with FEZ2           About GenesLikeMe

    Genetic Association Database (GAD): FEZ2
    Human Genome Epidemiology (HuGE) Navigator: FEZ2 (2 documents)

    Export disorders for FEZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FEZ2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with FEZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PubMed id 9096408)1, 2, 3 Bloom L. and Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. (PubMed id 14697253)1, 2, 9 Fujita T....Kuroda S. (Biochem. Biophys. Res. Commun. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2 Assmann E.M.... Kobarg J. (J. Biol. Chem. 2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9637 HGNC: 3660 AceView: FEZ2 Ensembl:ENSG00000171055 euGenes: HUgn9637
    ECgene: FEZ2 H-InvDB: FEZ2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FEZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FEZ2 gene:
    Search GeneIP for patents involving FEZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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