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Aliases for FEZ2 Gene

Aliases for FEZ2 Gene

  • Fasciculation And Elongation Protein Zeta 2 2 3 5
  • Zygin II 2 3 4
  • Fasciculation And Elongation Protein Zeta-2 3
  • Pre-T/NK Cell Associated Protein (3Cl) 3
  • Zygin 2 3
  • Zygin-2 4
  • HUM3CL 3

External Ids for FEZ2 Gene

Previous GeneCards Identifiers for FEZ2 Gene

  • GC02M036744
  • GC02M036926
  • GC02M036753
  • GC02M036691
  • GC02M036632
  • GC02M036775

Summaries for FEZ2 Gene

Entrez Gene Summary for FEZ2 Gene

  • This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEZ2 Gene

FEZ2 (Fasciculation And Elongation Protein Zeta 2) is a Protein Coding gene. An important paralog of this gene is FEZ1.

UniProtKB/Swiss-Prot for FEZ2 Gene

  • Involved in axonal outgrowth and fasciculation.

Gene Wiki entry for FEZ2 Gene

Additional gene information for FEZ2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZ2 Gene

Genomics for FEZ2 Gene

Regulatory Elements for FEZ2 Gene

Enhancers for FEZ2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H036555 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.6 +82.8 82756 16.4 TBP SIN3A RCOR1 FOS ZC3H11A CEBPB TGIF2 ZFP69B IKZF1 CEBPA FEZ2 CRIM1 GC02M036589 GC02P036523
GH02H036553 0.9 Ensembl ENCODE dbSUPER 29.3 +92.2 92173 1 POLR2A GABPA FEZ2 GC02P036523 GC02M036589
GH02H036537 0.7 dbSUPER 28 +105.4 105442 5.4 ATF1 SOX6 TAL1 HLF MAFG REST NFIC JUND ZNF316 MAFF FEZ2 CRIM1 GC02P036523 GC02M036589
GH02H036547 0.6 ENCODE dbSUPER 29.7 +97.2 97182 3 JUN FEZ2 GC02P036523 GC02M036589
GH02H036596 1 ENCODE 17.3 +48.3 48293 1.9 ARID4B SIN3A DMAP1 GLIS2 ELK1 ZNF143 RUNX3 SP3 SP5 NFYC FEZ2 CRIM1 GC02M036589
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FEZ2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FEZ2 Gene

Genomic Locations for FEZ2 Gene
114,283 bases
Minus strand

Genomic View for FEZ2 Gene

Genes around FEZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEZ2 Gene

Proteins for FEZ2 Gene

  • Protein details for FEZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fasciculation and elongation protein zeta-2
    Protein Accession:
    Secondary Accessions:
    • Q5EBN3
    • Q76LN0
    • Q99690

    Protein attributes for FEZ2 Gene

    353 amino acids
    Molecular mass:
    39666 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.
    • Sequence=AAF14865.1; Type=Frameshift; Positions=41, 51, 71, 78, 84; Evidence={ECO:0000305};

    Alternative splice isoforms for FEZ2 Gene


neXtProt entry for FEZ2 Gene

Post-translational modifications for FEZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FEZ2 Gene

Domains & Families for FEZ2 Gene

Gene Families for FEZ2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FEZ2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zygin family.
  • Belongs to the zygin family.
genes like me logo Genes that share domains with FEZ2: view

Function for FEZ2 Gene

Molecular function for FEZ2 Gene

UniProtKB/Swiss-Prot Function:
Involved in axonal outgrowth and fasciculation.

Phenotypes From GWAS Catalog for FEZ2 Gene

Gene Ontology (GO) - Molecular Function for FEZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14690447
genes like me logo Genes that share ontologies with FEZ2: view
genes like me logo Genes that share phenotypes with FEZ2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEZ2 Gene

Localization for FEZ2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEZ2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0030424 axon IBA --
genes like me logo Genes that share ontologies with FEZ2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FEZ2 Gene

Pathways & Interactions for FEZ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FEZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9096408
GO:0007399 nervous system development TAS 9096408
GO:0007411 axon guidance TAS 9096408
GO:1902902 negative regulation of autophagosome assembly IMP 25495476
genes like me logo Genes that share ontologies with FEZ2: view

No data available for Pathways by source and SIGNOR curated interactions for FEZ2 Gene

Drugs & Compounds for FEZ2 Gene

No Compound Related Data Available

Transcripts for FEZ2 Gene

Unigene Clusters for FEZ2 Gene

Fasciculation and elongation protein zeta 2 (zygin II):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: -
SP5: - - - - -
SP6: -
SP8: -

Relevant External Links for FEZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEZ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FEZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEZ2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for FEZ2 Gene

This gene is overexpressed in Heart (24.0), Placenta (19.7), Ovary (9.7), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEZ2 Gene

Protein tissue co-expression partners for FEZ2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FEZ2 Gene:


SOURCE GeneReport for Unigene cluster for FEZ2 Gene:


mRNA Expression by UniProt/SwissProt for FEZ2 Gene:

Tissue specificity: Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.

Evidence on tissue expression from TISSUES for FEZ2 Gene

  • Adrenal gland(4.3)
  • Liver(4.3)
  • Nervous system(3.4)
  • Muscle(3.2)
genes like me logo Genes that share expression patterns with FEZ2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FEZ2 Gene

Orthologs for FEZ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FEZ2 33 34
  • 96.56 (n)
(Canis familiaris)
Mammalia FEZ2 33 34
  • 91.49 (n)
(Bos Taurus)
Mammalia FEZ2 33 34
  • 90.69 (n)
(Rattus norvegicus)
Mammalia Fez2 33
  • 88.44 (n)
(Monodelphis domestica)
Mammalia FEZ2 34
  • 87 (a)
(Mus musculus)
Mammalia Fez2 33 16 34
  • 86.31 (n)
(Ornithorhynchus anatinus)
Mammalia FEZ2 34
  • 86 (a)
(Gallus gallus)
Aves FEZ2 33 34
  • 79.72 (n)
(Anolis carolinensis)
Reptilia FEZ2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fez2 33
  • 72.14 (n)
(Danio rerio)
Actinopterygii si:dkey-288i20.2 33
  • 61.94 (n)
FEZ2 (1 of 2) 34
  • 55 (a)
FEZ2 (2 of 2) 34
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Unc-76 34 33
  • 53.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003014 33
  • 52.3 (n)
(Caenorhabditis elegans)
Secernentea unc-76 35 33 34
  • 47.57 (n)
Species where no ortholog for FEZ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEZ2 Gene

Gene Tree for FEZ2 (if available)
Gene Tree for FEZ2 (if available)

Paralogs for FEZ2 Gene

Paralogs for FEZ2 Gene

genes like me logo Genes that share paralogs with FEZ2: view

Variants for FEZ2 Gene

Sequence variations from dbSNP and Humsavar for FEZ2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000030893 -- 36,555,302(+) TCACT(A/C)ATGAT intron-variant
rs1000055876 -- 36,572,834(+) CATGA(C/G)CTGAG intron-variant
rs1000105948 -- 36,566,045(+) TGAAA(C/T)TGGTT intron-variant
rs1000185615 -- 36,577,901(+) CTTTA(C/G)CCAAC intron-variant
rs1000242401 -- 36,558,742(+) AAACA(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEZ2 Gene

Variant ID Type Subtype PubMed ID
nsv2681 CNV deletion 18451855
nsv1121998 CNV deletion 24896259
nsv1071587 CNV deletion 25765185
esv3590396 CNV loss 21293372
esv3590395 CNV loss 21293372
esv3590394 CNV loss 21293372
esv2719923 CNV deletion 23290073
esv2662106 CNV deletion 23128226

Variation tolerance for FEZ2 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEZ2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEZ2 Gene

Disorders for FEZ2 Gene

Relevant External Links for FEZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FEZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEZ2 Gene

Publications for FEZ2 Gene

  1. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. (PMID: 14697253) Fujita T … Kuroda S (Biochemical and biophysical research communications 2004) 3 4 22 60
  2. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PMID: 9096408) Bloom L … Horvitz HR (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 60
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann EM … Kobarg J (The Journal of biological chemistry 2006) 3 4 60

Products for FEZ2 Gene

Sources for FEZ2 Gene

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