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Aliases for FEZ1 Gene

Aliases for FEZ1 Gene

  • Fasciculation And Elongation Protein Zeta 1 (Zygin I) 2 3
  • Zygin I 3 4
  • Zygin-1 3 4
  • Fasciculation And Elongation Protein Zeta-1 3

External Ids for FEZ1 Gene

Summaries for FEZ1 Gene

Entrez Gene Summary for FEZ1 Gene

  • This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEZ1 Gene

FEZ1 (Fasciculation And Elongation Protein Zeta 1 (Zygin I)) is a Protein Coding gene. Diseases associated with FEZ1 include esophageal cancer and schizophrenia. GO annotations related to this gene include protein N-terminus binding and gamma-tubulin binding. An important paralog of this gene is FEZ2.

UniProtKB/Swiss-Prot for FEZ1 Gene

  • May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Gene Wiki entry for FEZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEZ1 Gene

Genomics for FEZ1 Gene

Genomic Location for FEZ1 Gene

Start:
125,445,745 bp from pter
End:
125,496,317 bp from pter
Size:
50,573 bases
Orientation:
Minus strand

Genomic View for FEZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FEZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEZ1 Gene

Regulatory Elements for FEZ1 Gene

Proteins for FEZ1 Gene

  • Protein details for FEZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99689-FEZ1_HUMAN
    Recommended name:
    Fasciculation and elongation protein zeta-1
    Protein Accession:
    Q99689
    Secondary Accessions:
    • O00679
    • O00728
    • Q6IBI7

    Protein attributes for FEZ1 Gene

    Size:
    392 amino acids
    Molecular mass:
    45119 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation.

    Alternative splice isoforms for FEZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FEZ1 Gene

Proteomics data for FEZ1 Gene at MOPED

Post-translational modifications for FEZ1 Gene

  • Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.
  • Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEZ1 Gene

No data available for DME Specific Peptides for FEZ1 Gene

Domains for FEZ1 Gene

Protein Domains for FEZ1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

FEZ1_HUMAN
Family:
  • Belongs to the zygin family.:
    • Q99689
genes like me logo Genes that share domains with FEZ1: view

No data available for Gene Families for FEZ1 Gene

Function for FEZ1 Gene

Molecular function for FEZ1 Gene

UniProtKB/Swiss-Prot Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Gene Ontology (GO) - Molecular Function for FEZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI 14690447
GO:0043015 gamma-tubulin binding IEA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with FEZ1: view
genes like me logo Genes that share phenotypes with FEZ1: view

Animal Models for FEZ1 Gene

MGI Knock Outs for FEZ1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FEZ1 Gene

Localization for FEZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEZ1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FEZ1 Gene COMPARTMENTS Subcellular localization image for FEZ1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FEZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IEA --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with FEZ1: view

Pathways for FEZ1 Gene

SuperPathways for FEZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FEZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007155 cell adhesion TAS 9096408
GO:0007399 nervous system development TAS 9096408
GO:0007411 axon guidance TAS 9096408
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with FEZ1: view

No data available for Pathways by source for FEZ1 Gene

Transcripts for FEZ1 Gene

Unigene Clusters for FEZ1 Gene

Fasciculation and elongation protein zeta 1 (zygin I):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FEZ1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - -
SP11: -
SP12:
SP13: - -
SP14:
SP15: -

ExUns: 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FEZ1 Gene

GeneLoc Exon Structure for
FEZ1
ECgene alternative splicing isoforms for
FEZ1

Expression for FEZ1 Gene

mRNA expression in normal human tissues for FEZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEZ1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.5) and Brain - Substantia nigra (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FEZ1 Gene

SOURCE GeneReport for Unigene cluster for FEZ1 Gene Hs.224008

mRNA Expression by UniProt/SwissProt for FEZ1 Gene

Q99689-FEZ1_HUMAN
Tissue specificity: Mainly expressed in brain
genes like me logo Genes that share expressions with FEZ1: view

Orthologs for FEZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEZ1 36
  • 99.57 (n)
  • 100 (a)
FEZ1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FEZ1 36
  • 92.35 (n)
  • 96.94 (a)
FEZ1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FEZ1 36
  • 93.96 (n)
  • 96.17 (a)
FEZ1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fez1 36
  • 91.16 (n)
  • 95.41 (a)
Fez1 16
Fez1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FEZ1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FEZ1 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fez1 36
  • 91.33 (n)
  • 95.66 (a)
chicken
(Gallus gallus)
Aves FEZ1 36
  • 67.9 (n)
  • 65.24 (a)
FEZ1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FEZ1 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fez1 36
  • 73.83 (n)
  • 79.8 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27157 36
fez1 36
  • 70.21 (n)
  • 70.98 (a)
fez1 37
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Unc-76 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-76 37
  • 28 (a)
OneToMany
Species with no ortholog for FEZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEZ1 Gene

ENSEMBL:
Gene Tree for FEZ1 (if available)
TreeFam:
Gene Tree for FEZ1 (if available)

Paralogs for FEZ1 Gene

Paralogs for FEZ1 Gene

Selected SIMAP similar genes for FEZ1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FEZ1: view

Variants for FEZ1 Gene

Sequence variations from dbSNP and Humsavar for FEZ1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3763 -- 125,445,965(+) TTGCT(C/T)GTGTT utr-variant-3-prime
rs485680 -- 125,483,385(-) TTCTT(A/G)TAATG intron-variant
rs488462 -- 125,483,093(-) TTGCT(C/G)TCACG intron-variant
rs510050 -- 125,485,877(-) gctcc(A/G)cttcc intron-variant
rs511536 -- 125,492,322(-) GAGCC(C/T)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEZ1 Gene

Variant ID Type Subtype PubMed ID
nsv532 CNV Loss 18451855
esv32964 CNV Gain+Loss 17666407

Relevant External Links for FEZ1 Gene

HapMap Linkage Disequilibrium report
FEZ1

Disorders for FEZ1 Gene

(2) University of Copenhagen DISEASES for FEZ1 Gene

(2) Novoseek inferred disease relationships for FEZ1 Gene

Disease -log(P) Hits PubMed IDs
lissencephaly sequence, isolated 88 2
schizophrenia 44.4 10

Relevant External Links for FEZ1

Genetic Association Database (GAD)
FEZ1
Human Genome Epidemiology (HuGE) Navigator
FEZ1
genes like me logo Genes that share disorders with FEZ1: view

No data available for UniProtKB/Swiss-Prot for FEZ1 Gene

Publications for FEZ1 Gene

  1. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. (PMID: 15843383) Suzuki T. … Sawa H. (J. Biol. Chem. 2005) 2 3 23
  2. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann E.M. … Kobarg J. (J. Biol. Chem. 2006) 3 4 23
  3. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. (PMID: 17374448) Koga M. … Arinami T. (Neurosci. Lett. 2007) 3 23 49
  4. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PMID: 9096408) Bloom L. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  5. Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. (PMID: 15466860) Okumura F. … Nakayama K. (J. Biol. Chem. 2004) 3 4

Products for FEZ1 Gene

Sources for FEZ1 Gene

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