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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FEZ1 Gene

protein-coding   GIFtS: 57
GCID: GC11M125349

Fasciculation And Elongation Protein Zeta 1 (Zygin I)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fasciculation And Elongation Protein Zeta 1 (Zygin I)1 2
Zygin I2 3
Fasciculation And Elongation Protein Zeta-12
zygin-12
Zygin-13

External Ids:    HGNC: 36591   Entrez Gene: 96382   Ensembl: ENSG000001495577   OMIM: 6048255   UniProtKB: Q996893   

Export aliases for FEZ1 gene to outside databases

Previous GC identifers: GC11M127316 GC11M126828 GC11M124853 GC11M124820 GC11M121257


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FEZ1 Gene:
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and
elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants
partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The
N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding
different isoforms of this protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for FEZ1 Gene: 
FEZ1 (fasciculation and elongation protein zeta 1 (zygin I)) is a protein-coding gene. Diseases associated with FEZ1 include progressive multifocal leukoencephalopathy, and lissencephaly. GO annotations related to this gene include gamma-tubulin binding and protein N-terminus binding. An important paralog of this gene is FEZ2.

UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular
morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans
unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other
cargos along microtubules

Gene Wiki entry for FEZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FEZ1 gene promoter:
         Max1   ATF-2   MZF-1   FAC1   POU2F1   POU2F1a   c-Jun   MRF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFEZ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FEZ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

FEZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEZ1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M125349:  view genomic region     (about GC identifiers)

Start:
125,315,641 bp from pter      End:
125,366,213 bp from pter
Size:
50,573 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689 (See protein sequence)
Recommended Name: Fasciculation and elongation protein zeta-1  
Size: 392 amino acids; 45119 Da
Subunit: Homodimer; difulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable
region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with
SAP30L. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and
UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane (By
similarity). Note=Co-localizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the
cytoplasm by activation of the PKC zeta (By similarity)
Secondary accessions: O00679 O00728 Q6IBI7
Alternative splicing: 2 isoforms:  Q99689-1   Q99689-2   

Explore the universe of human proteins at neXtProt for FEZ1: NX_Q99689

Explore proteomics data for FEZ1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination
  • UniProtKB: Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important
    for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99689

  • FEZ1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FEZ1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005094.1  NP_072043.1  

    ENSEMBL proteins: 
     ENSP00000278919   ENSP00000463116   ENSP00000393425   ENSP00000431521   ENSP00000434803  

    Human Recombinant Protein Products for FEZ1: 
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    Novus Biologicals FEZ1 Proteins
    Novus Biologicals FEZ1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IEA--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane IEA--
    GO:0015630microtubule cytoskeleton IDA--

    FEZ1 for ontologies           About GeneDecksing



    FEZ1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015642 FEZ_1
     IPR011680 FEZ

    Graphical View of Domain Structure for InterPro Entry Q99689

    ProtoNet protein and cluster: Q99689

    1 Blocks protein domain: IPB011680 FEZ-like

    UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Similarity: Belongs to the zygin family


    FEZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEZ1_HUMAN, Q99689
    Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular
    morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans
    unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other
    cargos along microtubules

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI14690447
    GO:0043015gamma-tubulin binding IEA--
    GO:0047485protein N-terminus binding IEA--
         
    FEZ1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fez1):
     behavior/neurological  growth/size  homeostasis/metabolism  nervous system 

    FEZ1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fez1tm1Kei for FEZ1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FEZ1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FEZ1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FEZ1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FEZ1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FEZ1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FEZ1:
    hsa-miR-205* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidFEZ1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FEZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for FEZ1 (Q996891, 2, 3 ENSP000002789194) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-396435,EBI-466029 MINT-3978028 MINT-3978231 MINT-3981322 I2D: score=5 STRING: ENSP00000347184
    KIAA1377Q9P2H01, 2, 3, ENSP000002634684EBI-396435,EBI-473176 MINT-3981135 MINT-3981754 I2D: score=3 STRING: ENSP00000263468
    TXNDC9O145301, 2, 3EBI-396435,EBI-707554 MINT-63059 I2D: score=5 
    CCL7P800982, 3, ENSP000002003074MINT-64011 I2D: score=5 STRING: ENSP00000200307
    HEATR2Q86Y562, 3, ENSP000002974404MINT-64842 I2D: score=5 STRING: ENSP00000297440
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007155cell adhesion TAS9096408
    GO:0007399nervous system development TAS9096408
    GO:0007411axon guidance TAS9096408
    GO:0010976positive regulation of neuron projection development IEA--

    FEZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FEZ1

    Search CenterWatch for drugs/clinical trials and news about FEZ1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FEZ1 gene (2 alternative transcripts): 
    NM_005103.4  NM_022549.3  

    Unigene Clusters for FEZ1:

    Fasciculation and elongation protein zeta 1 (zygin I)
    Hs.224008  [show with all ESTs], Hs.732083  [show with all ESTs]
    Unigene Representative Sequences: NM_005103, NM_022549
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526507 ENST00000527350 ENST00000278919(uc001qbx.3) ENST00000524427
    ENST00000530096 ENST00000528863 ENST00000532778 ENST00000392709(uc010sbc.2)
    ENST00000577924 ENST00000533294 ENST00000534022 ENST00000532981 ENST00000366139(uc001qby.2)
    ENST00000524435 ENST00000527534
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FEZ1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FEZ1:
    hsa-miR-205* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidFEZ1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): FEZ1 (NM_005103)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEZ1
    Sirion Biotech Customized lentivirus for stable overexpression of FEZ1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEZ1

    Additional mRNA sequence: U60062.1 

    22 DOTS entries:

    DT.100786869  DT.120738689  DT.446832  DT.100708021  DT.217433  DT.100786860  DT.100740867  DT.100786857 
    DT.92432043  DT.100786864  DT.120738744  DT.100786865  DT.120738715  DT.120738718  DT.120738778  DT.102837598 
    DT.120738723  DT.120738767  DT.92432039  DT.95277055  DT.95346794  DT.40225596 

    24/238 AceView cDNA sequences (see all 238):

    BM664408 BG675803 BE855743 BX402676 CR615559 BG059635 BM989186 BM991286 
    F08237 AW028069 CR456817 BX360583 BM706333 AI359557 AA331493 AW027008 
    AI754566 AV654756 AA432199 BC009545 AI150749 BI035920 N47326 NM_005103 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for FEZ1 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:              -     -                 -     -                 -           -     -                 -                 -           -           -               
    SP2:                                                              -           -     -     -     -     -                 -           -           -               
    SP3:                                                                          -     -                 -                                                         
    SP4:                                                              -     -     -     -                 -                 -           -                           
    SP5:                                      -     -                 -           -     -                                                                           

    ExUns: 13b · 13c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for FEZ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FEZ1 expression in normal human tissues (normalized intensities)      FEZ1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGGCAGG
    FEZ1 Expression
    About this image


    FEZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Globus Pallidus   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Spinal Cord (Nervous System)
             Dorsal Root Ganglion   
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles

    See FEZ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FEZ1

    SOURCE GeneReport for Unigene clusters: Hs.224008 Hs.732083

    UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Tissue specificity: Mainly expressed in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FEZ1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fez11 , 5 fasciculation and elongation protein zeta 1 (zygin more1, 5 91.16(n)1
    95.41(a)1
      9 (20.69 cM)5
    2351801  NM_183171.41  NP_898994.21 
     368219395 
    chicken
    (Gallus gallus)
    Aves FEZ11 fasciculation and elongation protein zeta 1 (zygin more 68.38(n)
    66.1(a)
      425587  XM_423333.3  XP_423333.3 
    lizard
    (Anolis carolinensis)
    Reptilia FEZ16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343367.1(1021309-1055035)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271572 Danio rerio cDNA clone MGC73258 IMAGE4200293, complete more 76.58(n)    BC059593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-766
    Unc-76
    23(a)
    1 → many
    X(1974643-1987981)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-766
    Protein UNC-76, isoform a
    26(a)
    1 → many
    V(15071756-15080144)


    ENSEMBL Gene Tree for FEZ1 (if available)
    TreeFam Gene Tree for FEZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FEZ1 gene
    FEZ22  
    2 SIMAP similar genes for FEZ1 using alignment to 3 protein entries:     FEZ1_HUMAN (see all proteins):
    DKFZp779C2259    FEZ2

    FEZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/935 SNPs in FEZ1 are shown (see all 935)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356440621,2
    C--125205968(+) AATGC-/TTTTTT 1 -- int10--------
    rs772050561,2
    C,F--125315150(+) GTTTCG/ATCAAG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1916124001,2
    --125315213(+) TTCCCA/GCAGGC 1 -- ds50010--------
    rs1114525281,2
    F--125315395(+) CCCTGG/ATGCAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1157570401,2
    F--125315588(+) AGCCCG/ATCTCT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1402799641,2
    C--125315732(+) TGAGCA/GGTGAA 1 -- ut310--------
    rs1879001681,2
    --125315837(+) CCAACA/GGCAAA 1 -- ut310--------
    rs37631,2
    H--125315861(+) TTGCTC/TGTGTT 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 418
    rs1502258681,2
    C--125316014(+) TGCAAC/TGAGAA 1 -- int10--------
    rs2008546601,2
    --125316029(+) GGAGGA/GGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FEZ1 (125315641 - 125366213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FEZ1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv532CNV Loss18451855
    esv32964CNV Gain+Loss17666407

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing FEZ1:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing FEZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for FEZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604825    OMIM disorders: --

    4 diseases for FEZ1:    About MalaCards
    progressive multifocal leukoencephalopathy    lissencephaly    schizophrenia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FEZ1:
    Progressive multifocal leukoencephalopathy     Phaeochromocytoma

    FEZ1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FEZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly sequence, isolated 88 2 16510495 (1), 17117617 (1)
    schizophrenia 44.4 16 17374448 (4), 18647754 (3), 17664024 (1), 16510495 (1) (see all 5)

    Genetic Association Database (GAD): FEZ1
    Human Genome Epidemiology (HuGE) Navigator: FEZ1 (13 documents)

    Export disorders for FEZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FEZ1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with FEZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PubMed id 9096408)1, 2, 3 Bloom L. and Horvitz H.R. (1997)
    2. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. (PubMed id 15843383)1, 3, 9 Suzuki T....Sawa H. (2005)
    3. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2, 9 Assmann E.M.... Kobarg J. (2006)
    4. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. (PubMed id 17374448)1, 4, 9 Koga M....Arinami T. (2007)
    5. Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport. (PubMed id 20812761)1, 2 Alborghetti M.R.... Kobarg J. (2010)
    6. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. (PubMed id 19251251)1, 4 Tomppo L....Peltonen L. (2009)
    7. Genetic association and post-mortem brain mRNA analys is of DISC1 and related genes in schizophrenia. (PubMed id 19632097)1, 4 Rastogi A....Wong A.H. (2009)
    8. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    9. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (2008)
    10. Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells. (PubMed id 18439996)1, 2 Lanza D.C....Kobarg J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9638 HGNC: 3659 AceView: FEZ1 Ensembl:ENSG00000149557 euGenes: HUgn9638
    ECgene: FEZ1 H-InvDB: FEZ1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FEZ1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FEZ1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FEZ1 gene:
    Search GeneIP for patents involving FEZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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