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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FEZ1 Gene

protein-coding   GIFtS: 55
GCID: GC11M125349

fasciculation and elongation protein zeta 1 (zygin I)
 Explore 5 diseases affiliated with
FEZ1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FEZ1    

Aliases
for FEZ1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fasciculation And Elongation Protein Zeta 1 (Zygin I)1 2
Zygin I2 3
Fasciculation And Elongation Protein Zeta-12
Zygin-13
Zygin-13

External Ids:    HGNC: 36591   Entrez Gene: 96382   Ensembl: ENSG000001495577   OMIM: 6048255   UniProtKB: Q996893   

Export aliases for FEZ1 gene to outside databases

Previous GC identifers: GC11M127316 GC11M126828 GC11M124853 GC11M124820 GC11M121257


Summaries
for FEZ1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FEZ1:
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation
within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial
locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the
gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein
have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular
morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans
unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other
cargos along microtubules

Gene Wiki entry for FEZ1


Genomic Views
for FEZ1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FEZ1 gene promoter:
         Max1   ATF-2   MZF-1   FAC1   POU2F1   POU2F1a   c-Jun   MRF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FEZ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FEZ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

FEZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEZ1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M125349:  view genomic region     (about GC identifiers)

Start:
 125,315,646 bp from pter      End:
 125,366,213 bp from pter
Size:
 50,568 bases      Orientation:
 minus strand

Proteins
for FEZ1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689 (See protein sequence)
Recommended Name: Fasciculation and elongation protein zeta-1  
Size: 392 amino acids; 45119 Da
Subunit: Homodimer; difulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable region
(V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with SAP30L.
Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and UVRAG.
Stabilizes the interaction between SCOC and UVRAG during amino acid starvation
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cell membrane (By similarity). Note=Co-localizes with both,
alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By
similarity)
Secondary accessions: O00679 O00728 Q6IBI7
Alternative splicing: 2 isoforms:  Q99689-1   Q99689-2   

Explore the universe of human proteins at neXtProt for FEZ1: NX_Q99689

Post-translational modifications:

  • Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination1
  • Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for
    • neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-261
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99689

    • FEZ1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005094.1  NP_072043.1  

    ENSEMBL proteins: 
     ENSP00000278919   ENSP00000463116   ENSP00000393425   ENSP00000431521   ENSP00000434803  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion ----
    GO:0005813centrosome IEA--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane IEA--


    FEZ1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FEZ1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FEZ1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015642 FEZ_1
     IPR011680 FEZ

    Graphical View of Domain Structure for InterPro Entry Q99689

    ProtoNet protein and cluster: Q99689

    1 Blocks protein family: IPB011680 FEZ-like

    UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Similarity: Belongs to the zygin family


    Function
    for FEZ1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular
    morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans
    unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other
    cargos along microtubules

    miRNA
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI16169070
    GO:0043015gamma-tubulin binding IEA--
    GO:0047485protein N-terminus binding IEA--


    FEZ1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fez1tm1Kei for FEZ1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fez1):
     behavior/neurological  growth/size  homeostasis/metabolism  nervous system 

    FEZ1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FEZ1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FEZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for FEZ1 (Q996891, 2, 3 ENSP000002789194) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-396435,EBI-466029 MINT-3978028 MINT-3978231 MINT-3981322 I2D: score=5 STRING: ENSP00000347184
    KIAA1377Q9P2H01, 2, 3, ENSP000002634684EBI-396435,EBI-473176 MINT-3981135 MINT-3981754 I2D: score=3 STRING: ENSP00000263468
    TXNDC9O145301, 2, 3EBI-396435,EBI-707554 MINT-63059 I2D: score=5 
    CCL7P800982, 3, ENSP000002003074MINT-64011 I2D: score=5 STRING: ENSP00000200307
    HEATR2Q86Y562, 3, ENSP000002974404MINT-64842 I2D: score=5 STRING: ENSP00000297440
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007155cell adhesion TAS9096408
    GO:0007399nervous system development TAS9096408
    GO:0007411axon guidance TAS9096408
    GO:0010976positive regulation of neuron projection development IEA--


    FEZ1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FEZ1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FEZ1
    Search CenterWatch for drugs/clinical trials and news about FEZ1 

    Transcripts
    for FEZ1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FEZ1 gene (2 alternative transcripts): 
    NM_005103.4  NM_022549.3  

    Unigene Clusters for FEZ1:

    Fasciculation and elongation protein zeta 1 (zygin I)
    Hs.224008  [show with all ESTs], Hs.732083  [show with all ESTs]
    Unigene Representative Sequences: NM_005103, NM_022549
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526507 ENST00000527350 ENST00000278919(uc001qbx.3) ENST00000524427
    ENST00000530096 ENST00000528863 ENST00000532778 ENST00000392709(uc010sbc.2)
    ENST00000529053 ENST00000577924 ENST00000533294 ENST00000534022 ENST00000532981
    ENST00000366139(uc001qby.2) ENST00000524435 ENST00000527534

    miRNA
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    hsa-miR-205* hsa-miR-1284
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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEZ1

    Additional cDNA sequence: U60062.1 

    22 DOTS entries:

    DT.100786869  DT.120738689  DT.446832  DT.100708021  DT.217433  DT.100786860  DT.100740867  DT.100786857 
    DT.92432043  DT.100786864  DT.120738744  DT.100786865  DT.120738715  DT.120738718  DT.120738778  DT.102837598 
    DT.120738723  DT.120738767  DT.92432039  DT.95277055  DT.95346794  DT.40225596 

    24/238 AceView cDNA sequences (see all 238):

    BX402676 BE855743 BI035920 AI359557 AI754816 F09340 BM664408 BG675803 
    BM696124 CR609364 AI150749 AA331493 AL540224 CR619971 CR593895 AA432199 
    F08237 F04470 N47326 BM991286 AI371007 CR456817 NM_005103 AV654756 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for FEZ1 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:              -     -                 -     -                 -           -     -                 -                 -           -           -               
    SP2:                                                              -           -     -     -     -     -                 -           -           -               
    SP3:                                                                          -     -                 -                                                         
    SP4:                                                              -     -     -     -                 -                 -           -                           
    SP5:                                      -     -                 -           -     -                                                                           

    ExUns: 13b · 13c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for FEZ1

    Expression
    for FEZ1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FEZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGGGCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FEZ1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesendoderm-like cells (Generation of mesend...)

    See FEZ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FEZ1

    SOURCE GeneReport for Unigene clusters: Hs.224008 Hs.732083

    UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Tissue specificity: Mainly expressed in brain

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    In Situ
    Assay Products:     
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    Orthologs
    for FEZ1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FEZ1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FEZ11 fasciculation and elongation protein zeta 1 (zygin more 68.38(n)
    66.1(a)    		   425587  XM_423333.3  XP_423333.3 
    lizard
    (Anolis carolinensis)    		 Reptilia FEZ16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343367.1(1021309-1047457)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.271572 Danio rerio cDNA clone MGC73258 IMAGE4200293, complete more 76.58(n)    BC059593.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Unc-766
    		 Unc-76
    		 26(a)
    		 1 → many
    		 X(1974643-1987981)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-766
    		 UNCoordinated family member (unc-76)
    		 28(a)
    		 1 → many
    		 V(15071739-15080127)


    ENSEMBL Gene Tree for FEZ1 (if available)
    TreeFam Gene Tree for FEZ1 (if available) 

    Paralogs
    for FEZ1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FEZ1 gene
    FEZ22  
    2 SIMAP similar genes for FEZ1 using alignment to 3 protein entries:     FEZ1_HUMAN (see all proteins):
    DKFZp779C2259    FEZ2

    FEZ1 for paralogs           About GeneDecksing



    Genomic Variants
    for FEZ1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/876 NCBI SNPs in FEZ1 are shown (see all 876)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs112200951,2
    		A,--121304796(+) AAAGAA/GAGAAA 1 -- us2k1 trp30--------
    rs112200961,2
    		--121304838(+) AAGAAA/GGAAAG 1 -- us2k1 trp30--------
    rs116009721,2
    		C,A,H,--121305047(+) TCAATA/GTGCTT 1 -- us2k14Minor allele frequency- G:0.15NA WA EA 360
    rs750986621,2
    		F,--121305161(+) TTACAG/CAGATA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs745232041,2
    		--121305172(+) TGAAAG/ACCAAT 1 -- us2k12Minor allele frequency- A:0.11CSA WA 120
    rs793175011,2
    		F,--121305179(+) CAATCC/AGATAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs116052071,2
    		C,F,A,H,--121305202(+) TTACAC/TTGCCT 1 -- us2k117Minor allele frequency- T:0.15NS EA NA WA 2336
    rs756322401,2
    		F,--121305327(+) CCAACC/TAGAAT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs748785771,2
    		F,--121305339(+) TAGGAC/ATAAGA 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs788853651,2
    		F,--121305414(+) AGAAAA/CTGGAT 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for FEZ1 (125315646 - 125366213 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FEZ1
         2 CNVs: 5037 6905

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing FEZ1:
    Pancreatic Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FEZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for FEZ1

    Disorders / Diseases
    for FEZ1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FEZ1 for disorders           About GeneDecksing

    OMIM gene information: 604825    OMIM disorders: --

    5 diseases for FEZ1:    About MalaCards
    progressive multifocal leukoencephalopathy    lissencephaly    huntington's disease    schizophrenia
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FEZ1:
    Progressive multifocal leukoencephalopathy     Phaeochromocytoma

    2 Novoseek disease relationships for FEZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly sequence, isolated 88 2 16510495 (1), 17117617 (1)
    schizophrenia 44.4 16 17374448 (4), 18647754 (3), 17664024 (1), 16510495 (1) (see all 5)

    Genetic Association Database (GAD): FEZ1
    Human Genome Epidemiology (HuGE) Navigator: FEZ1 (13 documents)

    Export disorders for FEZ1 gene to outside databases

    Publications
    for FEZ1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FEZ1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with FEZ1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PubMed id 9096408)1, 2, 3 Bloom L. and Horvitz H.R. (1997)
    2. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. (PubMed id 15843383)1, 3, 9 Suzuki T....Sawa H. (2005)
    3. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2, 9 Assmann E.M.... Kobarg J. (2006)
    4. Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport. (PubMed id 20812761)1, 2 Alborghetti M.R.... Kobarg J. (2010)
    5. Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells. (PubMed id 18439996)1, 2 Lanza D.C....Kobarg J. (2008)
    6. Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. (PubMed id 15522253)1, 4 Yamada K....Yoshikawa T. (2004)
    7. Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. (PubMed id 15466860)1, 2 Okumura F.... Nakayama K. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. (PubMed id 9971736)1, 9 Kuroda S....Tanizawa K. (1999)
    10. Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution. (PubMed id 18615714)1, 9 Lanza D.C....Kobarg J. (2009)

    External Searches for FEZ1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing FEZ1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9638 HGNC: 3659 AceView: FEZ1 Ensembl:ENSG00000149557 euGenes: HUgn9638
    ECgene: FEZ1 H-InvDB: FEZ1

    Other Databases showing FEZ1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FEZ1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FEZ1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FEZ1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FEZ1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FEZ1 gene:
    Search GeneIP for patents involving FEZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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