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FEZ1 Gene

protein-coding   GIFtS: 55
GCID: GC11M125316

Fasciculation And Elongation Protein Zeta 1 (Zygin I)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fasciculation And Elongation Protein Zeta 1 (Zygin I)1 2
Zygin I2 3
Fasciculation And Elongation Protein Zeta-12
zygin-12
Zygin-13

External Ids:    HGNC: 36591   Entrez Gene: 96382   Ensembl: ENSG000001495577   OMIM: 6048255   UniProtKB: Q996893   

Export aliases for FEZ1 gene to outside databases

Previous GC identifers: GC11M127316 GC11M126828 GC11M125349 GC11M124853 GC11M124820 GC11M121257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FEZ1 Gene:
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and
elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants
partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The
N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding
different isoforms of this protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for FEZ1 Gene:
FEZ1 (fasciculation and elongation protein zeta 1 (zygin I)) is a protein-coding gene. Diseases associated with FEZ1 include esophageal squamous cell carcinoma, and lissencephaly. GO annotations related to this gene include gamma-tubulin binding and protein N-terminus binding. An important paralog of this gene is FEZ2.

UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular
morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans
unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other
cargos along microtubules

Gene Wiki entry for FEZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FEZ1 gene promoter:
         Max1   ATF-2   MZF-1   FAC1   POU2F1   POU2F1a   c-Jun   MRF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFEZ1 promoter sequence
   Search Chromatin IP Primers for FEZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FEZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

FEZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEZ1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M125316:  view genomic region     (about GC identifiers)

Start:
125,315,641 bp from pter      End:
125,366,213 bp from pter
Size:
50,573 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689 (See protein sequence)
Recommended Name: Fasciculation and elongation protein zeta-1  
Size: 392 amino acids; 45119 Da
Subunit: Homodimer; disulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable
region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with
SAP30L. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and
UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation
Secondary accessions: O00679 O00728 Q6IBI7
Alternative splicing: 2 isoforms:  Q99689-1   Q99689-2   

Explore the universe of human proteins at neXtProt for FEZ1: NX_Q99689

Explore proteomics data for FEZ1 at MOPED

Post-translational modifications: 

  • Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination1
  • Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important
    for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-261
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FEZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005094.1  NP_072043.1  

    ENSEMBL proteins: 
     ENSP00000278919   ENSP00000463116   ENSP00000393425   ENSP00000431521   ENSP00000434803  

    FEZ1 Human Recombinant Protein Products:

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    Novus Biologicals FEZ1 Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015642 FEZ_1
     IPR011680 FEZ

    Graphical View of Domain Structure for InterPro Entry Q99689

    ProtoNet protein and cluster: Q99689

    1 Blocks protein domain: IPB011680 FEZ-like

    UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Similarity: Belongs to the zygin family


    FEZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEZ1_HUMAN, Q99689
    Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular
    morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans
    unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other
    cargos along microtubules

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI14690447
    GO:0043015gamma-tubulin binding IEA--
    GO:0047485protein N-terminus binding IEA--
         
    FEZ1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fez1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  nervous system 

    FEZ1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fez1tm1Kei for FEZ1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FEZ1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FEZ1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FEZ1

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FEZ1:
    hsa-miR-205* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidFEZ1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): FEZ1 (NM_005103)
    Sino Biological Human cDNA Clone for FEZ1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEZ1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FEZ1_HUMAN, Q99689: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane (By
    similarity). Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the
    cytoplasm by activation of the PKC zeta (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IEA--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane IEA--
    GO:0015630microtubule cytoskeleton IDA--

    FEZ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FEZ1
    Interactions:

        GeneGlobe Interaction Network for FEZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FEZ1 (Q996891, 2, 3 ENSP000002789194) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-396435,EBI-466029 MINT-3978028 MINT-3978231 MINT-3981322 I2D: score=5 STRING: ENSP00000347184
    KIAA1377Q9P2H01, 2, 3, ENSP000002634684EBI-396435,EBI-473176 MINT-3981135 MINT-3981754 I2D: score=3 STRING: ENSP00000263468
    TXNDC9O145301, 2, 3EBI-396435,EBI-707554 MINT-63059 I2D: score=5 
    CCL7P800982, 3, ENSP000002003074MINT-64011 I2D: score=5 STRING: ENSP00000200307
    HEATR2Q86Y562, 3, ENSP000002974404MINT-64842 I2D: score=5 STRING: ENSP00000297440
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007155cell adhesion TAS9096408
    GO:0007399nervous system development TAS9096408
    GO:0007411axon guidance TAS9096408
    GO:0010976positive regulation of neuron projection development IEA--

    FEZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FEZ1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FEZ1 gene (2 alternative transcripts): 
    NM_005103.4  NM_022549.3  

    Unigene Cluster for FEZ1:

    Fasciculation and elongation protein zeta 1 (zygin I)
    Hs.224008  [show with all ESTs]
    Unigene Representative Sequence: NM_005103
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526507 ENST00000527350 ENST00000278919(uc001qbx.3) ENST00000524427
    ENST00000530096 ENST00000528863 ENST00000532778 ENST00000392709(uc010sbc.2)
    ENST00000577924 ENST00000533294 ENST00000534022 ENST00000532981 ENST00000366139(uc001qby.2)
    ENST00000524435 ENST00000527534
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FEZ1:
    hsa-miR-205* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidFEZ1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FEZ1
    Predesigned siRNA for gene silencing in human, mouse, rat FEZ1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FEZ1 (NM_005103)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEZ1
    Primer
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    OriGene qPCR primer pairs and template standards for FEZ1
    OriGene qSTAR qPCR primer pairs in human, mouse for FEZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FEZ1
      QuantiTect SYBR Green Assays in human, mouse, rat FEZ1
      QuantiFast Probe-based Assays in human, mouse, rat FEZ1

    Additional mRNA sequence: 

    AK296554.1 BC009545.1 CR456817.1 CR541954.1 U60060.1 U69139.1 

    15 DOTS entries:

    DT.100786869  DT.120738689  DT.100708021  DT.446832  DT.100786857  DT.100740867  DT.100786864  DT.100786865 
    DT.120738778  DT.120738715  DT.92432039  DT.95277055  DT.95346794  DT.120738723  DT.40225596 

    Selected AceView cDNA sequences (see all 238):

    BX402676 AI265849 CR541954 AW162866 CR619971 BX360583 CR456817 BU740627 
    Z40914 CR596282 AL540224 AI753868 AL536128 BM704132 CR614380 BM663785 
    CR606763 CD511637 AV654756 AI359557 NM_005103 CR615559 BG675803 AI754816 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FEZ1 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:              -     -                 -     -                 -           -     -                 -                 -           -           -               
    SP2:                                                              -           -     -     -     -     -                 -           -           -               
    SP3:                                                                          -     -                 -                                                         
    SP4:                                                              -     -     -     -                 -                 -           -                           
    SP5:                                      -     -                 -           -     -                                                                           

    ExUns: 13b · 13c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for FEZ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FEZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGGCAGG
    FEZ1 Expression
    About this image


    FEZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Oligodendrocyte-like cells
             Globus Pallidus   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     NULL (Uncategorized)
             Neural rosettes
    FEZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FEZ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.224008

    UniProtKB/Swiss-Prot: FEZ1_HUMAN, Q99689
    Tissue specificity: Mainly expressed in brain

        Custom PCR Arrays for FEZ1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FEZ1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fez11 , 5 fasciculation and elongation protein zeta 1 (zygin more1, 5 91.16(n)1
    95.41(a)1
      9 (20.69 cM)5
    2351801  NM_183171.41  NP_898994.21 
     368219395 
    chicken
    (Gallus gallus)
    Aves FEZ11 fasciculation and elongation protein zeta 1 (zygin more 67.9(n)
    65.24(a)
      425587  XM_423333.4  XP_423333.3 
    lizard
    (Anolis carolinensis)
    Reptilia FEZ16
    fasciculation and elongation protein zeta 1 (zygin...
    81(a)
    1 ↔ 1
    GL343367.1(1021309-1055035)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fez11 fasciculation and elongation protein zeta 1 (zygin more 73.83(n)
    79.8(a)
      780367  NM_001079437.1  NP_001072905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271572 Danio rerio cDNA clone MGC73258 IMAGE4200293, complete more 76.58(n)    BC059593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-766
    Unc-76
    24(a)
    1 → many
    X(1974643-1987981)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-766
    Protein UNC-76, isoform b (unc-76) mRNA, complete ...
    28(a)
    1 → many
    V(15071756-15080144) WBGene00006808


    ENSEMBL Gene Tree for FEZ1 (if available)
    TreeFam Gene Tree for FEZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FEZ1 gene
    FEZ22  
    2 SIMAP similar genes for FEZ1 using alignment to 3 protein entries:     FEZ1_HUMAN (see all proteins):
    DKFZp779C2259    FEZ2

    FEZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FEZ1 (see all 935)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356440621,2
    C--125205968(+) AATGC-/TTTTTT 1 -- int10--------
    rs772050561,2
    C,F--125315150(+) GTTTCG/ATCAAG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1916124001,2
    --125315213(+) TTCCCA/GCAGGC 1 -- ds50010--------
    rs1114525281,2
    F--125315395(+) CCCTGG/ATGCAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1157570401,2
    F--125315588(+) AGCCCG/ATCTCT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1402799641,2
    C--125315732(+) TGAGCA/GGTGAA 1 -- ut310--------
    rs1879001681,2
    --125315837(+) CCAACA/GGCAAA 1 -- ut310--------
    rs37631,2
    H--125315861(+) TTGCTC/TGTGTT 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 418
    rs1502258681,2
    C--125316014(+) TGCAAC/TGAGAA 1 -- int10--------
    rs2008546601,2
    --125316029(+) GGAGGA/GGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FEZ1 (125315641 - 125366213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FEZ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv532CNV Loss18451855
    esv32964CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing FEZ1:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing FEZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for FEZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604825    OMIM disorders: --

    11 diseases for FEZ1:    
    About MalaCards
    esophageal squamous cell carcinoma    lissencephaly    progressive multifocal leukoencephalopathy    phaeochromocytoma
    schizophrenia    bronchiolitis    huntington's disease    bipolar disorder
    hiv-1    neuronitis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for FEZ1:
    Progressive multifocal leukoencephalopathy     Phaeochromocytoma

    FEZ1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FEZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly sequence, isolated 88 2 16510495 (1), 17117617 (1)
    schizophrenia 44.4 16 17374448 (4), 18647754 (3), 17664024 (1), 16510495 (1) (see all 5)

    Genetic Association Database (GAD): FEZ1
    Human Genome Epidemiology (HuGE) Navigator: FEZ1 (13 documents)

    Export disorders for FEZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FEZ1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with FEZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PubMed id 9096408)1, 2, 3 Bloom L. and Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. (PubMed id 15843383)1, 3, 9 Suzuki T....Sawa H. (J. Biol. Chem. 2005)
    3. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2, 9 Assmann E.M.... Kobarg J. (J. Biol. Chem. 2006)
    4. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. (PubMed id 17374448)1, 4, 9 Koga M....Arinami T. (Neurosci. Lett. 2007)
    5. Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport. (PubMed id 20812761)1, 2 Alborghetti M.R.... Kobarg J. (J. Proteome Res. 2010)
    6. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. (PubMed id 19251251)1, 4 Tomppo L....Peltonen L. (Biol. Psychiatry 2009)
    8. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. (PubMed id 19632097)1, 4 Rastogi A....Wong A.H. (Schizophr. Res. 2009)
    9. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (Nat. Genet. 2008)
    10. Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells. (PubMed id 18439996)1, 2 Lanza D.C.... Kobarg J. (Exp. Cell Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9638 HGNC: 3659 AceView: FEZ1 Ensembl:ENSG00000149557 euGenes: HUgn9638
    ECgene: FEZ1 H-InvDB: FEZ1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FEZ1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FEZ1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FEZ1 gene:
    Search GeneIP for patents involving FEZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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