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Aliases for FEV Gene

Aliases for FEV Gene

  • FEV, ETS Transcription Factor 2 3 5
  • PC12 ETS Domain-Containing Transcription Factor 1 3 4
  • Fifth Ewing Variant Protein 3 4
  • FEV (ETS Oncogene Family) 2 3
  • PET-1 3 4
  • FEV (Fifth Ewing Variant) 2
  • PC12 ETS Factor 1 4
  • Protein FEV 3
  • HSRNAFEV 3
  • PET1 4

External Ids for FEV Gene

Previous GeneCards Identifiers for FEV Gene

  • GC02M220050
  • GC02M219671
  • GC02M219554
  • GC02M219845
  • GC02M211699

Summaries for FEV Gene

Entrez Gene Summary for FEV Gene

  • This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEV Gene

FEV (FEV, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FEV include Ewing Sarcoma and Sudden Infant Death Syndrome. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is FLI1.

UniProtKB/Swiss-Prot for FEV Gene

  • Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEV Gene

Genomics for FEV Gene

Regulatory Elements for FEV Gene

Enhancers for FEV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G218908 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +76.1 76059 2.4 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A CNOT9 ENSG00000235024 CDK5R2 LINC00608 FEV CRYBA2 PRKAG3 ENSG00000269068 IHH PLCD4
GH02G219121 1.5 Ensembl ENCODE dbSUPER 10.7 -139.4 -139412 7.2 FOXA2 ATF1 ARID4B YBX1 TCF12 FOS SP5 KAT8 SREBF1 MIER3 SLC23A3 NHEJ1 IHH MIR375 LOC100129175 CRYBA2 FEV LINC00608 RETREG2 CNPPD1
GH02G218886 1.4 FANTOM5 ENCODE dbSUPER 10.5 +99.3 99258 0.5 HDGF TBP TBL1XR1 WRNIP1 SIN3A ZNF143 RELB IKZF2 CREM USF2 WNT6 RNU6-642P PRKAG3 LINC00608 FEV CRYBA2 WNT10A CNOT9 LOC105373882
GH02G218995 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.6 -10.8 -10809 1.5 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 ZNF143 KDM4B SP3 SP5 ZHX2 FEV CRYBA2 USP37 ZNF142 MIR375
GH02G219110 1.2 ENCODE dbSUPER 10.8 -126.6 -126625 3.0 ELF3 FOXA2 ATF1 MLX ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA IHH MIR375 LOC100129175 CRYBA2 FEV LINC00608 PTPRN NHEJ1 SLC23A3 CDK5R2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FEV on UCSC Golden Path with GeneCards custom track

Genomic Location for FEV Gene

Chromosome:
2
Start:
218,981,087 bp from pter
End:
218,985,657 bp from pter
Size:
4,571 bases
Orientation:
Minus strand

Genomic View for FEV Gene

Genes around FEV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEV Gene

Proteins for FEV Gene

  • Protein details for FEV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99581-FEV_HUMAN
    Recommended name:
    Protein FEV
    Protein Accession:
    Q99581

    Protein attributes for FEV Gene

    Size:
    238 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FEV Gene

neXtProt entry for FEV Gene

Post-translational modifications for FEV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEV Gene

Domains & Families for FEV Gene

Gene Families for FEV Gene

Protein Domains for FEV Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FEV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99581

UniProtKB/Swiss-Prot:

FEV_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with FEV: view

Function for FEV Gene

Molecular function for FEV Gene

GENATLAS Biochemistry:
fused with EWS in complex translocation t(2;21;22),only detected in adult prostate and small intestine
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

Gene Ontology (GO) - Molecular Function for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9121764
GO:0003714 transcription corepressor activity TAS 9121764
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FEV: view
genes like me logo Genes that share phenotypes with FEV: view

Animal Models for FEV Gene

MGI Knock Outs for FEV:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FEV

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FEV Gene

Localization for FEV Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEV Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEV gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with FEV: view

Pathways & Interactions for FEV Gene

genes like me logo Genes that share pathways with FEV: view

Pathways by source for FEV Gene

SIGNOR curated interactions for FEV Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9121764
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FEV: view

Drugs & Compounds for FEV Gene

No Compound Related Data Available

Transcripts for FEV Gene

mRNA/cDNA for FEV Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FEV Gene

FEV (ETS oncogene family):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FEV

Alternative Splicing Database (ASD) splice patterns (SP) for FEV Gene

No ASD Table

Relevant External Links for FEV Gene

GeneLoc Exon Structure for
FEV
ECgene alternative splicing isoforms for
FEV

Expression for FEV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FEV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEV Gene

This gene is overexpressed in Pituitary (x9.3), Prostate (x6.8), Brain - Putamen (basal ganglia) (x5.1), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of FEV Gene:

FEV

SOURCE GeneReport for Unigene cluster for FEV Gene:

Hs.234759

mRNA Expression by UniProt/SwissProt for FEV Gene:

Q99581-FEV_HUMAN
Tissue specificity: In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.

Evidence on tissue expression from TISSUES for FEV Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FEV: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEV Gene

Orthologs for FEV Gene

This gene was present in the common ancestor of animals.

Orthologs for FEV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEV 34
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia FEV 34 35
  • 91.56 (n)
oppossum
(Monodelphis domestica)
Mammalia FEV 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fev 34 16 35
  • 90.86 (n)
rat
(Rattus norvegicus)
Mammalia Fev 34
  • 89.17 (n)
chicken
(Gallus gallus)
Aves LOC100857480 34
  • 77.62 (n)
FEV 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fev 34
  • 73.33 (n)
zebrafish
(Danio rerio)
Actinopterygii fev 34 35
  • 72.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ets-5 35
  • 39 (a)
ManyToMany
ast-1 35
  • 24 (a)
ManyToMany
Species where no ortholog for FEV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEV Gene

ENSEMBL:
Gene Tree for FEV (if available)
TreeFam:
Gene Tree for FEV (if available)

Paralogs for FEV Gene

(15) SIMAP similar genes for FEV Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEV: view

Variants for FEV Gene

Sequence variations from dbSNP and Humsavar for FEV Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000030212 -- 218,987,387(+) TTTCC(C/G)CTTCA upstream-variant-2KB
rs1000192283 -- 218,981,525(+) CCCGT(A/C)CCCCT utr-variant-3-prime
rs1000582709 -- 218,983,001(+) TTGGC(A/C)TCTTA intron-variant
rs1000644750 -- 218,983,273(+) CCCGA(A/C/T)ACAAT intron-variant
rs1000710909 -- 218,981,697(+) GAGGC(G/T)GCGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FEV Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954839 CNV deletion 24416366

Variation tolerance for FEV Gene

Gene Damage Index Score: 0.25; 5.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEV Gene

Human Gene Mutation Database (HGMD)
FEV
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEV Gene

Disorders for FEV Gene

MalaCards: The human disease database

(2) MalaCards diseases for FEV Gene - From: GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
sudden infant death syndrome
  • cot death
- elite association - COSMIC cancer census association via MalaCards
Search FEV in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FEV_HUMAN
  • Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. {ECO:0000269 PubMed:9121764}.
  • Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269 PubMed:17597646}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for FEV

Genetic Association Database (GAD)
FEV
Human Genome Epidemiology (HuGE) Navigator
FEV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FEV
genes like me logo Genes that share disorders with FEV: view

No data available for Genatlas for FEV Gene

Publications for FEV Gene

  1. A new member of the ETS family fused to EWS in Ewing tumors. (PMID: 9121764) Peter M. … Delattre O. (Oncogene 1997) 2 3 4 22 64
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  4. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. (PMID: 19707175) Broadbelt K.G. … Beggs A.H. (Pediatr. Res. 2009) 3 46 64
  5. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B. … Hoffman P.L. (BMC Biol. 2009) 3 46 64

Products for FEV Gene

  • Addgene plasmids for FEV

Sources for FEV Gene

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