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Aliases for FEV Gene

Aliases for FEV Gene

  • FEV (ETS Oncogene Family) 2 3
  • PC12 ETS Domain-Containing Transcription Factor 1 3 4
  • Fifth Ewing Variant Protein 3 4
  • PET-1 3 4
  • FEV (Fifth Ewing Variant) 2
  • PC12 ETS Factor 1 4
  • HSRNAFEV 3
  • PET1 4

External Ids for FEV Gene

Previous GeneCards Identifiers for FEV Gene

  • GC02M220050
  • GC02M219671
  • GC02M219554
  • GC02M219845
  • GC02M211699

Summaries for FEV Gene

Entrez Gene Summary for FEV Gene

  • This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEV Gene

FEV (FEV (ETS Oncogene Family)) is a Protein Coding gene. Diseases associated with FEV include vestibulocochlear nerve disease and vestibular neuronitis. Among its related pathways are Transcriptional misregulation in cancer and SIDS Susceptibility Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for FEV Gene

  • Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEV Gene

Genomics for FEV Gene

Regulatory Elements for FEV Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FEV Gene

Chromosome:
2
Start:
218,981,087 bp from pter
End:
218,985,657 bp from pter
Size:
4,571 bases
Orientation:
Minus strand

Genomic View for FEV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FEV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEV Gene

Proteins for FEV Gene

  • Protein details for FEV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99581-FEV_HUMAN
    Recommended name:
    Protein FEV
    Protein Accession:
    Q99581

    Protein attributes for FEV Gene

    Size:
    238 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FEV Gene

neXtProt entry for FEV Gene

Proteomics data for FEV Gene at MOPED

Post-translational modifications for FEV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEV Gene

Domains & Families for FEV Gene

Gene Families for FEV Gene

Protein Domains for FEV Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FEV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99581

UniProtKB/Swiss-Prot:

FEV_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with FEV: view

Function for FEV Gene

Molecular function for FEV Gene

GENATLAS Biochemistry:
fused with EWS in complex translocation t(2;21;22),only detected in adult prostate and small intestine
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

Gene Ontology (GO) - Molecular Function for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9121764
GO:0003714 transcription corepressor activity TAS 9121764
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FEV: view
genes like me logo Genes that share phenotypes with FEV: view

Animal Models for FEV Gene

MGI Knock Outs for FEV:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FEV

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for FEV Gene

Localization for FEV Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEV Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FEV Gene COMPARTMENTS Subcellular localization image for FEV gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FEV: view

Pathways & Interactions for FEV Gene

genes like me logo Genes that share pathways with FEV: view

Pathways by source for FEV Gene

1 BioSystems pathway for FEV Gene
1 KEGG pathway for FEV Gene

Interacting Proteins for FEV Gene

SIGNOR curated interactions for FEV Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9121764
GO:0010628 positive regulation of gene expression --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FEV: view

Drugs & Compounds for FEV Gene

No Compound Related Data Available

Transcripts for FEV Gene

mRNA/cDNA for FEV Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FEV Gene

FEV (ETS oncogene family):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FEV

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEV Gene

No ASD Table

Relevant External Links for FEV Gene

GeneLoc Exon Structure for
FEV
ECgene alternative splicing isoforms for
FEV

Expression for FEV Gene

mRNA expression in normal human tissues for FEV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEV Gene

This gene is overexpressed in Pituitary (x9.3), Prostate (x6.8), Brain - Putamen (basal ganglia) (x5.1), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.7).

SOURCE GeneReport for Unigene cluster for FEV Gene Hs.234759

mRNA Expression by UniProt/SwissProt for FEV Gene

Q99581-FEV_HUMAN
Tissue specificity: In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
genes like me logo Genes that share expression patterns with FEV: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FEV Gene

Orthologs for FEV Gene

This gene was present in the common ancestor of animals.

Orthologs for FEV Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FEV 35
  • 91.56 (n)
  • 94.94 (a)
FEV 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fev 35
  • 90.86 (n)
  • 96.62 (a)
Fev 16
Fev 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FEV 35
  • 99.12 (n)
  • 98.23 (a)
rat
(Rattus norvegicus)
Mammalia Fev 35
  • 89.17 (n)
  • 96.62 (a)
oppossum
(Monodelphis domestica)
Mammalia FEV 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857480 35
  • 77.62 (n)
  • 75.24 (a)
FEV 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fev 35
  • 73.33 (n)
  • 72.86 (a)
zebrafish
(Danio rerio)
Actinopterygii fev 35
  • 72.14 (n)
  • 75.71 (a)
fev 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ast-1 36
  • 24 (a)
ManyToMany
ets-5 36
  • 39 (a)
ManyToMany
Species with no ortholog for FEV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEV Gene

ENSEMBL:
Gene Tree for FEV (if available)
TreeFam:
Gene Tree for FEV (if available)

Paralogs for FEV Gene

Paralogs for FEV Gene

(15) SIMAP similar genes for FEV Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEV: view

Variants for FEV Gene

Sequence variations from dbSNP and Humsavar for FEV Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs364565 -- 218,984,369(+) AAAAG(A/C/G)GCCCC intron-variant
rs364906 -- 218,984,438(+) ACCCG(C/G)CTCCT intron-variant
rs375436 -- 218,981,881(+) GCGGG(G/T)CGAGG missense, reference
rs388221 -- 218,984,445(+) TCCTC(C/T)TCCCG intron-variant
rs391542 -- 218,984,438(+) CCCGC(C/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEV Gene

Variant ID Type Subtype PubMed ID
nsv834542 CNV Gain 17160897

Variation tolerance for FEV Gene

Gene Damage Index Score: 0.25; 5.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEV Gene

HapMap Linkage Disequilibrium report
FEV
Human Gene Mutation Database (HGMD)
FEV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEV Gene

Disorders for FEV Gene

MalaCards: The human disease database

(4) MalaCards diseases for FEV Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vestibulocochlear nerve disease
  • acoustic nerve disorder nos
vestibular neuronitis
  • epidemic neurolabyrinthitis
ewing sarcoma
  • neuroepithelioma
sudden infant death syndrome
  • cot death
- elite association
Search FEV in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FEV_HUMAN
  • Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.
  • Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269 PubMed:17597646}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for FEV

Genetic Association Database (GAD)
FEV
Human Genome Epidemiology (HuGE) Navigator
FEV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FEV
genes like me logo Genes that share disorders with FEV: view

No data available for Genatlas for FEV Gene

Publications for FEV Gene

  1. A new member of the ETS family fused to EWS in Ewing tumors. (PMID: 9121764) Peter M. … Delattre O. (Oncogene 1997) 2 23 67
  2. Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness. (PMID: 19786075) Schaefer T.L. … Williams M.T. (Neuroscience 2009) 23 67
  3. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. (PMID: 15986391) Iyo A.H. … Austin M.C. (Synapse 2005) 23 67
  4. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. (PMID: 10575032) Hendricks T. … Deneris E.S. (J. Neurosci. 1999) 23 67
  5. Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. (PMID: 24100022) Wellman C.L. … Holmes A. (Exp. Neurol. 2013) 67

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