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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FEV Gene

protein-coding   GIFtS: 53
GCID: GC02M219845

FEV (ETS Oncogene Family)

(Previous name: FEV (fifth Ewing variant))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FEV (ETS Oncogene Family)1 2     PET-12
Fifth Ewing Variant Protein2 3     Protein FEV2
PC12 ETS Domain-Containing Transcription Factor 12 3     PET13
FEV (Fifth Ewing Variant)1     Pet-13
HSRNAFEV2     PC12 ETS Factor 13

External Ids:    HGNC: 185621   Entrez Gene: 547382   Ensembl: ENSG000001634977   OMIM: 6071505   UniProtKB: Q995813   

Export aliases for FEV gene to outside databases

Previous GC identifers: GC02M220050 GC02M219671 GC02M219554 GC02M211699


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FEV Gene:
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid
ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may
act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT)
system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating
disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome
translocations. (provided by RefSeq, Jul 2008)

GeneCards Summary for FEV Gene: 
FEV (FEV (ETS oncogene family)) is a protein-coding gene. Diseases associated with FEV include eating disorder, and enamel erosion. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: FEV_HUMAN, Q99581
Function: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a
transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic
neurons. May play a role in cell growth




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FEV gene promoter:
         HOXA9B   HOXA9   Spz1   NRSF form 1   NRSF form 2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFEV promoter sequence
   Search SABiosciences Chromatin IP Primers for FEV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36

FEV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEV gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M219845:  view genomic region     (about GC identifiers)

Start:
219,845,809 bp from pter      End:
219,850,379 bp from pter
Size:
4,571 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FEV_HUMAN, Q99581 (See protein sequence)
Recommended Name: Protein FEV  
Size: 238 amino acids; 25030 Da
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for FEV:
2YPR (3D)        3ZP5 (3D)    

Explore the universe of human proteins at neXtProt for FEV: NX_Q99581

Explore proteomics data for FEV at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99581

  • FEV Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FEV Protein Expression
    REFSEQ proteins: NP_059991.1  
    ENSEMBL proteins: 
     ENSP00000295727  

    Human Recombinant Protein Products for FEV: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for FEV
    OriGene Protein Over-expression Lysate for FEV
    OriGene MassSpec for FEV 
    OriGene Custom Protein Services for FEV
    GenScript Custom Purified and Recombinant Proteins Services for FEV
    Novus Biologicals FEV Proteins
    Novus Biologicals FEV Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FEV 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    FEV for ontologies           About GeneDecksing



    FEV Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals FEV Antibodies
    Abcam antibodies for FEV
    Cloud-Clone Corp. Antibodies for FEV 
    Search ThermoFisher Antibodies for FEV
    LSBio Antibodies in human, mouse, rat for FEV 

    Assay Products for FEV: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FEV 
    Cloud-Clone Corp. CLIAs for FEV


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q99581

    ProtoNet protein and cluster: Q99581

    UniProtKB/Swiss-Prot: FEV_HUMAN, Q99581
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    FEV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEV_HUMAN, Q99581
    Function: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a
    transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic
    neurons. May play a role in cell growth

         Genatlas biochemistry entry for FEV:
    fused with EWS in complex translocation t(2;21;22),only detected in adult prostate and small intestine

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS9121764
    GO:0043565sequence-specific DNA binding IEA--
         
    FEV for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FEV:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fev):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 

    FEV for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FEV: Fevtm1Esd Fevtm2.1Esd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FEV 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FEV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FEV 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FEV 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FEV
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FEV
    SwitchGear 3'UTR luciferase reporter plasmidFEV 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FEV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FEV

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FEV
    Sirion Biotech Customized adenovirus for overexpression of FEV

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FEV (see all 4)
    OriGene ORF clones in mouse, rat for FEV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FEV (NM_017521)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEV
    Sirion Biotech Customized lentivirus for stable overexpression of FEV 
                         Customized lentivirus expression plasmids for stable overexpression of FEV 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FEV
    Search LifeMap BioReagents cell lines for FEV
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEV


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FEV About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FEV
        SIDS Susceptibility Pathways


    1         Kegg Pathway  (Kegg details for FEV):
        Transcriptional misregulation in cancer


    FEV for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FEV

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9121764
    GO:0010628positive regulation of gene expression ----
    GO:0042551neuron maturation IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--

    FEV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FEV

    Search CenterWatch for drugs/clinical trials and news about FEV

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FEV gene: 
    NM_017521.2  

    Unigene Cluster for FEV:

    FEV (ETS oncogene family)
    Hs.234759  [show with all ESTs]
    Unigene Representative Sequence: NM_017521
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295727(uc002vji.1) ENST00000470119
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FEV
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FEV
    SwitchGear 3'UTR luciferase reporter plasmidFEV 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FEV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FEV
    Clone
    Products:
         
    OriGene clones in human, mouse for FEV (see all 4)
    OriGene ORF clones in mouse, rat for FEV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FEV (NM_017521)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEV
    Sirion Biotech Customized lentivirus for stable overexpression of FEV 
                         Customized lentivirus expression plasmids for stable overexpression of FEV 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FEV
    OriGene qSTAR qPCR primer pairs in human, mouse for FEV
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FEV
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FEV
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEV

    Additional mRNA sequence: 

    BC023511.2 Y08976.1 

    3 DOTS entries:

    DT.75200143  DT.99961343  DT.99962249 

    22 AceView cDNA sequences:

    CA867392 BC023511 CA771327 CA867675 CA771025 CB069127 NM_017521 AW138530 
    BI438572 Y08976 BQ777436 BF447326 BM128563 BQ788110 BX280874 BM128343 
    CB069363 BI194956 BE262829 BI438899 BU603585 BF314312 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FEV expression in normal human tissues (normalized intensities)      FEV embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCCGCCGC
    FEV Expression
    About this image


    FEV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             Lateral funiculus   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Pancreas (Endocrine System)

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See FEV Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FEV

    SOURCE GeneReport for Unigene cluster: Hs.234759

    UniProtKB/Swiss-Prot: FEV_HUMAN, Q99581
    Tissue specificity: In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median
    raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine

        SABiosciences Custom PCR Arrays for FEV
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEV
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FEV gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fev1 , 5 FEV (ETS oncogene family)1, 5 90.86(n)1
    96.62(a)1
      1 (38.54 cM)5
    2602981  NM_153111.21  NP_694751.11 
     748815095 
    chicken
    (Gallus gallus)
    Aves LOC1008574801 protein FEV-like 77.62(n)
    75.24(a)
      100857480  XM_003641646.1  XP_003641694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fev1 FEV (ETS oncogene family) 72.14(n)
    75.71(a)
      791175  NM_001080657.1  NP_001074126.1 


    ENSEMBL Gene Tree for FEV (if available)
    TreeFam Gene Tree for FEV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FEV gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ETS22  ELK12  ERG2  ETV42  ETV22  FLI12  ELK32  
    15 SIMAP similar genes for FEV using alignment to 1 protein entry:     FEV_HUMAN:
    GABPA    GABPAP    ETV2    ETV5    ETS2    EWSR1/FLI1 fusion
    ETV1    FLI1    ERG    ETS1    DDX5-ETV4 fusion    ELK3
    ETV4    ERF    ELK1

    FEV for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 SNPs in FEV are shown (see all 121)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850780651,2
    --219229019(+) AGATGA/GGGTGA 1 -- ds50010--------
    rs730890731,2
    C--219229305(+) TGGCAG/AGGTGG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1139964371,2
    F--219229373(+) GCGGGC/AGGCGC 1 -- ds50011Minor allele frequency- A:0.14WA 118
    rs1474188101,2
    C--219229777(+) CAGGCA/GGAAAT 1 -- ut310--------
    rs4512531,2
    C,H--219229778(+) AGGCGG/AAAATG 1 -- ut316Minor allele frequency- A:0.00MN NS EA NA 606
    rs1390499271,2
    --219229892(+) GACTGC/TGGGGT 1 -- ut310--------
    rs1498685661,2
    C--219229893(+) ACTGCA/GGGGTG 1 -- ut310--------
    rs130252231,2
    C,H--219229922(+) TACCAG/TACAAG 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs793540231,2
    C,F--219230004(+) TTGACG/AGAGGC 1 -- ut311Minor allele frequency- A:0.05WA 118
    rs1909494141,2
    C--219230012(+) GGCTCC/TCGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FEV (219845809 - 219850379 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FEV:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834542CNV Gain17160897


    Human Gene Mutation Database (HGMD): FEV
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FEV
    DNA2.0 Custom Variant and Variant Library Synthesis for FEV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607150    OMIM disorders: --

    UniProtKB/Swiss-Prot: FEV_HUMAN, Q99581
  • Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1
    year that remains unexplained after a thorough case investigation, including performance of a complete autopsy,
    examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include
    respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism,
    but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Note=Disease
    susceptibility may be associated with variations affecting the gene represented in this entry
  • Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation
    t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity

  • 11 diseases for FEV:    About MalaCards
    eating disorder    enamel erosion    aphasia    hemiplegia
    sudden infant death syndrome    plasmacytoma    anorexia nervosa    sarcoma
    neuronitis    alcoholism    prostatitis


    FEV for disorders           About GeneDecksing

    Genetic Association Database (GAD): FEV
    Human Genome Epidemiology (HuGE) Navigator: FEV (11 documents)

    Export disorders for FEV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FEV gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with FEV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new member of the ETS family fused to EWS in Ewing tumors. (PubMed id 9121764)1, 2, 3, 9 Peter M.... Delattre O. (1997)
    2. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    3. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    4. Serotonin-related FEV gene variant in the sudden infa nt death syndrome is a common polymorphism in the African-American population. (PubMed id 19707175)1, 4 Broadbelt K.G....Beggs A.H. (2009)
    5. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    7. Sudden infant death syndrome: rare mutation in the serotonin system FEV gene. (PubMed id 17597646)1, 2 Rand C.M....Weese-Mayer D.E. (2007)
    8. The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons. (PubMed id 15003288)1, 2 Maurer P....de Launoit Y. (2004)
    9. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. (PubMed id 12761502)1, 2 Maurer P.... Baert J.-L. (2003)
    10. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. (PubMed id 15986391)2, 9 Iyo A.H.... Austin M.C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54738 HGNC: 18562 AceView: FEV Ensembl:ENSG00000163497 euGenes: HUgn54738
    ECgene: FEV Kegg: 54738 H-InvDB: FEV

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FEV Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FEV Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FEV gene:
    Search GeneIP for patents involving FEV

    GeneCards and IP:
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