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Aliases for FEV Gene

Aliases for FEV Gene

  • FEV, ETS Transcription Factor 2 3 5
  • PC12 ETS Domain-Containing Transcription Factor 1 3 4
  • Fifth Ewing Variant Protein 3 4
  • FEV (ETS Oncogene Family) 2 3
  • PET-1 3 4
  • FEV (Fifth Ewing Variant) 2
  • PC12 ETS Factor 1 4
  • Protein FEV 3
  • HSRNAFEV 3
  • PET1 4

External Ids for FEV Gene

Previous GeneCards Identifiers for FEV Gene

  • GC02M220050
  • GC02M219671
  • GC02M219554
  • GC02M219845
  • GC02M211699

Summaries for FEV Gene

Entrez Gene Summary for FEV Gene

  • This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEV Gene

FEV (FEV, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FEV include Sudden Infant Death Syndrome and Ewing Sarcoma. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is FLI1.

UniProtKB/Swiss-Prot for FEV Gene

  • Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

Additional gene information for FEV Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEV Gene

Genomics for FEV Gene

GeneHancer (GH) Regulatory Elements for FEV Gene

Promoters and enhancers for FEV Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I218985 Promoter 1 EPDnew 550.8 +0.1 76 0.1 ATF1 SUZ12 ETS1 E2F1 ZNF335 CTBP1 GLIS2 ZNF366 PATZ1 VEZF1 GC02P218985 FEV LINC00608
GH02I218986 Promoter 0.8 EPDnew 550.8 +0.5 453 0.1 ZNF148 ZNF335 SUZ12 ZBTB26 GABPA EZH2 FEV GC02P218985 LINC00608
GH02I218908 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +76.1 76059 2.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 CDK5R2 ENSG00000235024 ENSG00000269068
GH02I219121 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.7 -139.4 -139412 7.2 CLOCK ATF1 FOXA2 ARID4B YBX1 TCF12 FOS ATF7 RUNX3 RXRA SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 CNPPD1 RETREG2
GH02I218995 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.6 -10.8 -10808 1.5 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF143 ATF7 SP3 SP5 FEV CRYBA2 USP37 ZNF142 MIR375
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FEV on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FEV gene promoter:

Genomic Locations for FEV Gene

Genomic Locations for FEV Gene
chr2:218,981,087-218,985,657
(GRCh38/hg38)
Size:
4,571 bases
Orientation:
Minus strand
chr2:219,845,809-219,850,379
(GRCh37/hg19)

Genomic View for FEV Gene

Genes around FEV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEV Gene

Proteins for FEV Gene

  • Protein details for FEV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99581-FEV_HUMAN
    Recommended name:
    Protein FEV
    Protein Accession:
    Q99581

    Protein attributes for FEV Gene

    Size:
    238 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FEV Gene

neXtProt entry for FEV Gene

Post-translational modifications for FEV Gene

No Post-translational modifications

Other Protein References for FEV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEV Gene

Domains & Families for FEV Gene

Gene Families for FEV Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FEV Gene

Suggested Antigen Peptide Sequences for FEV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99581

UniProtKB/Swiss-Prot:

FEV_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with FEV: view

Function for FEV Gene

Molecular function for FEV Gene

GENATLAS Biochemistry:
fused with EWS in complex translocation t(2;21;22),only detected in adult prostate and small intestine
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

Phenotypes From GWAS Catalog for FEV Gene

Gene Ontology (GO) - Molecular Function for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 9121764
GO:0003714 transcription corepressor activity TAS 9121764
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FEV: view
genes like me logo Genes that share phenotypes with FEV: view

Animal Models for FEV Gene

MGI Knock Outs for FEV:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FEV

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FEV Gene

Localization for FEV Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEV Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEV gene
Compartment Confidence
nucleus 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with FEV: view

Pathways & Interactions for FEV Gene

genes like me logo Genes that share pathways with FEV: view

Pathways by source for FEV Gene

SIGNOR curated interactions for FEV Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006366 transcription by RNA polymerase II TAS 9121764
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FEV: view

Drugs & Compounds for FEV Gene

No Compound Related Data Available

Transcripts for FEV Gene

mRNA/cDNA for FEV Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FEV Gene

FEV (ETS oncogene family):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FEV

Alternative Splicing Database (ASD) splice patterns (SP) for FEV Gene

No ASD Table

Relevant External Links for FEV Gene

GeneLoc Exon Structure for
FEV
ECgene alternative splicing isoforms for
FEV

Expression for FEV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FEV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEV Gene

This gene is overexpressed in Pituitary (x9.3), Prostate (x6.8), Brain - Putamen (basal ganglia) (x5.1), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of FEV Gene:

FEV

SOURCE GeneReport for Unigene cluster for FEV Gene:

Hs.234759

mRNA Expression by UniProt/SwissProt for FEV Gene:

Q99581-FEV_HUMAN
Tissue specificity: In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.

Evidence on tissue expression from TISSUES for FEV Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FEV: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEV Gene

Orthologs for FEV Gene

This gene was present in the common ancestor of animals.

Orthologs for FEV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEV 33
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia FEV 33 34
  • 91.56 (n)
oppossum
(Monodelphis domestica)
Mammalia FEV 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fev 33 16 34
  • 90.86 (n)
rat
(Rattus norvegicus)
Mammalia Fev 33
  • 89.17 (n)
chicken
(Gallus gallus)
Aves LOC100857480 33
  • 77.62 (n)
FEV 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fev 33
  • 73.33 (n)
zebrafish
(Danio rerio)
Actinopterygii fev 33 34
  • 72.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ets-5 34
  • 39 (a)
ManyToMany
ast-1 34
  • 24 (a)
ManyToMany
Species where no ortholog for FEV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEV Gene

ENSEMBL:
Gene Tree for FEV (if available)
TreeFam:
Gene Tree for FEV (if available)

Paralogs for FEV Gene

(15) SIMAP similar genes for FEV Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEV: view

Variants for FEV Gene

Sequence variations from dbSNP and Humsavar for FEV Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000030212 -- 218,987,387(-) C/G upstream_transcript_variant
rs1000192283 -- 218,981,525(-) C/A/G 3_prime_UTR_variant
rs1000582709 -- 218,983,001(-) C/A intron_variant
rs1000644750 -- 218,983,273(-) T/A/C intron_variant
rs1000710909 -- 218,981,697(-) T/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for FEV Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954839 CNV deletion 24416366

Variation tolerance for FEV Gene

Gene Damage Index Score: 0.25; 5.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEV Gene

Human Gene Mutation Database (HGMD)
FEV
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEV Gene

Disorders for FEV Gene

MalaCards: The human disease database

(2) MalaCards diseases for FEV Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
sudden infant death syndrome
  • sids
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards
Search FEV in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FEV_HUMAN
  • Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. {ECO:0000269 PubMed:9121764}.
  • Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269 PubMed:17597646}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for FEV

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FEV: view

No data available for Genatlas for FEV Gene

Publications for FEV Gene

  1. A new member of the ETS family fused to EWS in Ewing tumors. (PMID: 9121764) Peter M … Delattre O (Oncogene 1997) 2 3 4 22 58
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 44 58
  5. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. (PMID: 19707175) Broadbelt KG … Beggs AH (Pediatric research 2009) 3 44 58

Products for FEV Gene

Sources for FEV Gene

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