Aliases for FEV Gene
Aliases for FEV Gene
External Ids for FEV Gene
- HGNC: 18562
- Entrez Gene: 54738
- Ensembl: ENSG00000163497
- OMIM: 607150
- UniProtKB: Q99581
Previous GeneCards Identifiers for FEV Gene
- GC02M220050
- GC02M219671
- GC02M219554
- GC02M219845
- GC02M211699
Summaries for FEV Gene
-
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
GeneCards Summary for FEV Gene
FEV (FEV, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FEV include Ewing Sarcoma and Sudden Infant Death Syndrome. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is FLI1.
UniProtKB/Swiss-Prot for FEV Gene
-
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEV Gene
Genomics for FEV Gene
Regulatory Elements for FEV Gene
Enhancers for FEV Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FEV on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FEV gene promoter:
Regulatory Element Products
Genomic Location for FEV Gene
- Chromosome:
- 2
- Start:
- 218,981,087 bp from pter
- End:
- 218,985,657 bp from pter
- Size:
- 4,571 bases
- Orientation:
- Minus strand
Genomic View for FEV Gene
Genes around FEV on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by Ensembl
- 2q35 by Entrez Gene
- 2q35 by HGNC
FEV Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FEV Gene
Proteins for FEV Gene
-
Protein details for FEV Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99581-FEV_HUMAN
- Recommended name:
- Protein FEV
- Protein Accession:
- Q99581
Protein attributes for FEV Gene
- Size:
- 238 amino acids
- Molecular mass:
- 25030 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for FEV Gene
Other Protein References for FEV Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FEV
-
Abcam antibodies for FEV
- Invitrogen Antibodies for FEV
- antibodies-online Antibodies for FEV: See all 12
- Search GeneTex for Antibodies for FEV
Protein Products
-
OriGene Purified Proteins for FEV
- Search Origene for MassSpec and Protein Over-expression Lysates for FEV
- Origene Custom Protein Services for FEV
- antibodies-online Proteins for FEV: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FEV
-
Abcam proteins for FEV
Assay Products
- antibodies-online Kits for FEV: See all 1
No data available for DME Specific Peptides for FEV Gene
Domains & Families for FEV Gene
Gene Families for FEV Gene
Protein Domains for FEV Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FEV Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99581- Family:
-
- Belongs to the ETS family.
Function for FEV Gene
Molecular function for FEV Gene
- GENATLAS Biochemistry:
- fused with EWS in complex translocation t(2;21;22),only detected in adult prostate and small intestine
- UniProtKB/Swiss-Prot Function:
- Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 9121764 |
| GO:0003714 | transcription corepressor activity | TAS | 9121764 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for FEV Gene
- MGI mutant phenotypes for FEV:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FEV:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased IL-8 secretion
- Wnt reporter downregulated
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Decreased viability with TRAIL
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FEV gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEV gene
- Search ViGene Biosciences for FEV
CRISPR Products
-
OriGene CRISPR knockouts for FEV
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEV
- GenScript: Design CRISPR guide RNA sequences for FEV
miRNA Products
- Search ViGene Biosciences for FEV
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEV
- Browse OriGene Inhibitory RNA Products For FEV
-
ViGene Biosciences ready-to-package AAV shRNAs for FEV gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FEV
Cell Line Products
-
Horizon Cell Lines for FEV
-
ViGene Biosciences adenoviral particle packaged cDNA for FEV gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FEV gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEV gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11257) for FEV
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FEV Gene
Localization for FEV Gene
Subcellular locations from UniProtKB/Swiss-Prot for FEV Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for FEV Gene
Pathways by source for FEV Gene
1 BioSystems pathway for FEV Gene
1 KEGG pathway for FEV Gene
Interacting Proteins for FEV Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IBA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 9121764 |
| GO:0007275 | multicellular organism development | IEA | -- |
Transcripts for FEV Gene
mRNA/cDNA for FEV Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FEV Gene
CRISPR Products
-
OriGene CRISPR knockouts for FEV
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEV
- GenScript: Design CRISPR guide RNA sequences for FEV
miRNA Products
- Search ViGene Biosciences for FEV
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEV
- Browse OriGene Inhibitory RNA Products For FEV
-
ViGene Biosciences ready-to-package AAV shRNAs for FEV gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FEV
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11257) for FEV
Expression for FEV Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Kidney (Urinary System)
- Ureteric Bud Tip Cells Ureteric Bud
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FEV Gene
This gene is overexpressed in Pituitary (x9.3), Prostate (x6.8), Brain - Putamen (basal ganglia) (x5.1), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.7).
NURSA nuclear receptor signaling pathways regulating expression of FEV Gene:
FEVSOURCE GeneReport for Unigene cluster for FEV Gene:
Hs.234759mRNA Expression by UniProt/SwissProt for FEV Gene:
Q99581-FEV_HUMAN
Tissue specificity:
In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
Evidence on tissue expression from TISSUES for FEV Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for FEV
-
OriGene qPCR primer pairs and template standards for FEV
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEV Gene
Orthologs for FEV Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FEV 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FEV 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FEV 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fev 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fev 34 |
|
||
| chicken (Gallus gallus) |
Aves | LOC100857480 34 |
|
||
| FEV 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fev 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fev 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ets65A 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ets-5 35 |
|
ManyToMany | |
| ast-1 35 |
|
ManyToMany |
- Species where no ortholog for FEV was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FEV Gene
Paralogs for FEV Gene
(15) SIMAP similar genes for FEV Gene using alignment to 1 proteins:
Variants for FEV Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030212 | -- | 218,987,387(+) | TTTCC(C/G)CTTCA | upstream-variant-2KB | |
| rs1000192283 | -- | 218,981,525(+) | CCCGT(A/C)CCCCT | utr-variant-3-prime | |
| rs1000582709 | -- | 218,983,001(+) | TTGGC(A/C)TCTTA | intron-variant | |
| rs1000644750 | -- | 218,983,273(+) | CCCGA(A/C/T)ACAAT | intron-variant | |
| rs1000710909 | -- | 218,981,697(+) | GAGGC(G/T)GCGGC | reference, synonymous-codon |
Gene Damage Index Score:
0.25;
5.70% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FEV Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEV Gene
Disorders for FEV Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ewing sarcoma |
|
|
| sudden infant death syndrome |
|
|
Search FEV in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FEV_HUMAN- Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. {ECO:0000269 PubMed:9121764}.
- Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269 PubMed:17597646}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Relevant External Links for FEV
No data available for Genatlas for FEV Gene
Publications for FEV Gene
- A new member of the ETS family fused to EWS in Ewing tumors. (PMID: 9121764) Peter M. … Delattre O. (Oncogene 1997) 2 3 4 22 64
- Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
- The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
- Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. (PMID: 19707175) Broadbelt K.G. … Beggs A.H. (Pediatr. Res. 2009) 3 46 64
- Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B. … Hoffman P.L. (BMC Biol. 2009) 3 46 64
Products for FEV Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FEV
- Search Origene for MassSpec and Protein Over-expression Lysates for FEV
- Origene Custom Protein Services for FEV
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FEV
- Browse OriGene Inhibitory RNA Products For FEV
- OriGene qPCR primer pairs and template standards for FEV
- OriGene qPCR primer pairs for FEV
- OriGene CRISPR knockouts for FEV
- OriGene ORF clones in human for FEV
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FEV in any vector
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- GenScript: Design CRISPR guide RNA sequences for FEV
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FEV
- Novus Biologicals proteins and lysates for FEV
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FEV
- Abcam proteins for FEV
- Search for Assays for FEV at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for FEV
- antibodies-online Antibodies for FEV: See all 12
- antibodies-online Kits for FEV: See all 1
- antibodies-online Proteins for FEV: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for FEV
- Search GeneTex for Proteins for FEV
- ViGene Biosciences adenoviral particle packaged cDNA for FEV gene
- ViGene Biosciences lentiviral particle packaged cDNA for FEV gene
- ViGene Biosciences ready-to-package AAV shRNAs for FEV gene
- Search ViGene Biosciences for FEV
- Horizon Cell Lines for FEV
- Cyagen custom Knockout/knockin (KOKI) mouse models for FEV
- VectorBuilder custom plasmid, inducible vectors for FEV
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FEV
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FEV Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (28) RNAdb
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- (50) eBioscience
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- (52) Cell Signaling Technology
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- (55) HORDE
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- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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