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Aliases for FETUB Gene

Aliases for FETUB Gene

  • Fetuin B 2 3 5
  • Fetuin-Like Protein IRL685 3 4
  • 16G2 3 4
  • Gugu 3 4
  • Fetuin-B 3
  • IRL685 3

External Ids for FETUB Gene

Previous GeneCards Identifiers for FETUB Gene

  • GC03P183129
  • GC03P187615
  • GC03P187760
  • GC03P187679
  • GC03P187840
  • GC03P186353
  • GC03P183767

Summaries for FETUB Gene

Entrez Gene Summary for FETUB Gene

  • The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FETUB Gene

FETUB (Fetuin B) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is AHSG.

UniProtKB/Swiss-Prot for FETUB Gene

  • Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Wiki entry for FETUB Gene

Additional gene information for FETUB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FETUB Gene

Genomics for FETUB Gene

Regulatory Elements for FETUB Gene

Enhancers for FETUB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H186752 1.2 Ensembl ENCODE 10.6 +118.3 118306 3 FOXA2 ARID4B BRCA1 YY1 TCF12 ZNF121 ATF7 FOS REST KAT8 KNG1 EIF4A2 SNORA63 SNORA81 ENSG00000200418 RFC4 FETUB ENSG00000231724 AHSG HRG
GH03H186588 1.2 Ensembl ENCODE 10.4 -45.9 -45919 3 PKNOX1 FOXA2 ARNT BRCA1 RAD21 RARA GTF3C2 SLC30A9 ZNF366 SCRT2 ENSG00000200418 TRA2B TBCCD1 AHSG SNORD2 EIF4A2 SNORA63 SNORA81 SNORA4 ENSG00000231724
GH03H186597 1 ENCODE 11 -36.2 -36182 3 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 ZNF766 ATF7 FETUB KNG1 HRG ENSG00000283390 AHSG
GH03H186596 1 Ensembl ENCODE 10.4 -38.8 -38832 0 HDAC1 ATF1 JUN CEBPG ZBTB40 IRF9 CTBP1 TRIM24 ZNF584 ATF7 FETUB KNG1 HRG RFC4 ENSG00000231724 ENSG00000283390 AHSG
GH03H186640 0.6 ENCODE 17.3 +4.7 4724 1 MAX REST FOXA1 NR2F2 JUND ATF3 CEBPA HNF4G HNF4A FETUB HRG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FETUB on UCSC Golden Path with GeneCards custom track

Genomic Location for FETUB Gene

Chromosome:
3
Start:
186,635,832 bp from pter
End:
186,653,141 bp from pter
Size:
17,310 bases
Orientation:
Plus strand

Genomic View for FETUB Gene

Genes around FETUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FETUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FETUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FETUB Gene

Proteins for FETUB Gene

  • Protein details for FETUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM5-FETUB_HUMAN
    Recommended name:
    Fetuin-B
    Protein Accession:
    Q9UGM5
    Secondary Accessions:
    • B2RCW6
    • E9PG06
    • Q1RMZ0
    • Q5J876
    • Q6DK58
    • Q6GRB6
    • Q9Y6Z0

    Protein attributes for FETUB Gene

    Size:
    382 amino acids
    Molecular mass:
    42055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FETUB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FETUB Gene

Post-translational modifications for FETUB Gene

  • Glycosylation at isoforms=237, posLast=136136, isoforms=2182, isoforms=2289, and isoforms=2292
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for FETUB

No data available for DME Specific Peptides for FETUB Gene

Domains & Families for FETUB Gene

Gene Families for FETUB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FETUB Gene

Suggested Antigen Peptide Sequences for FETUB Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGM5

UniProtKB/Swiss-Prot:

FETUB_HUMAN :
  • Belongs to the fetuin family.
Family:
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with FETUB: view

Function for FETUB Gene

Molecular function for FETUB Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Phenotypes From GWAS Catalog for FETUB Gene

Gene Ontology (GO) - Molecular Function for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004857 enzyme inhibitor activity IEA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity ISS,IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with FETUB: view
genes like me logo Genes that share phenotypes with FETUB: view

Animal Models for FETUB Gene

MGI Knock Outs for FETUB:

Animal Model Products

  • Taconic Biosciences Mouse Models for FETUB

CRISPR Products

miRNA for FETUB Gene

miRTarBase miRNAs that target FETUB

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FETUB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FETUB Gene

Localization for FETUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FETUB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FETUB gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FETUB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FETUB Gene

Pathways & Interactions for FETUB Gene

SuperPathways for FETUB Gene

No Data Available

Interacting Proteins for FETUB Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265029%0d%0a9606.ENSP00000216225%0d%0a9606.ENSP00000365944%0d%0a9606.ENSP00000251547%0d%0a
Selected Interacting proteins: Q9UGM5-FETUB_HUMAN ENSP00000265029 for FETUB Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization ISS --
GO:0007339 binding of sperm to zona pellucida IBA,ISS --
GO:0008150 biological_process ND --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity ISS --
genes like me logo Genes that share ontologies with FETUB: view

No data available for Pathways by source and SIGNOR curated interactions for FETUB Gene

Drugs & Compounds for FETUB Gene

No Compound Related Data Available

Transcripts for FETUB Gene

Unigene Clusters for FETUB Gene

Fetuin B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FETUB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FETUB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for FETUB Gene

GeneLoc Exon Structure for
FETUB
ECgene alternative splicing isoforms for
FETUB

Expression for FETUB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FETUB Gene

mRNA differential expression in normal tissues according to GTEx for FETUB Gene

This gene is overexpressed in Liver (x42.6).

Protein differential expression in normal tissues from HIPED for FETUB Gene

This gene is overexpressed in Serum (26.9), Plasma (14.9), and Synovial fluid (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FETUB Gene



Protein tissue co-expression partners for FETUB Gene

NURSA nuclear receptor signaling pathways regulating expression of FETUB Gene:

FETUB

SOURCE GeneReport for Unigene cluster for FETUB Gene:

Hs.81073

mRNA Expression by UniProt/SwissProt for FETUB Gene:

Q9UGM5-FETUB_HUMAN
Tissue specificity: Liver and testis.

Evidence on tissue expression from TISSUES for FETUB Gene

  • Liver(4.7)
  • Bone marrow(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FETUB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FETUB Gene

Orthologs for FETUB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FETUB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FETUB 33 34
  • 98.43 (n)
dog
(Canis familiaris)
Mammalia FETUB 33 34
  • 79.93 (n)
cow
(Bos Taurus)
Mammalia FETUB 33 34
  • 77.42 (n)
mouse
(Mus musculus)
Mammalia Fetub 33 16 34
  • 74.79 (n)
rat
(Rattus norvegicus)
Mammalia Fetub 33
  • 72.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FETUB 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FETUB 33 34
  • 53.78 (n)
lizard
(Anolis carolinensis)
Reptilia FETUB 34
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fetub 33
  • 46.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563738 33
  • 53.78 (n)
FETUB (3 of 3) 34
  • 30 (a)
OneToMany
FETUB (2 of 3) 34
  • 26 (a)
OneToMany
fetub 34
  • 23 (a)
OneToMany
Species where no ortholog for FETUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FETUB Gene

ENSEMBL:
Gene Tree for FETUB (if available)
TreeFam:
Gene Tree for FETUB (if available)

Paralogs for FETUB Gene

Paralogs for FETUB Gene

(1) SIMAP similar genes for FETUB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FETUB: view

Variants for FETUB Gene

Sequence variations from dbSNP and Humsavar for FETUB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000123933 -- 186,639,445(+) GAGAG(A/T)TAGGG intron-variant, upstream-variant-2KB
rs1000456445 -- 186,638,650(+) TGTTA(C/T)TGGAT intron-variant, upstream-variant-2KB
rs1000745700 -- 186,647,708(+) GAATA(A/G)TAAGA intron-variant
rs1000755221 -- 186,641,944(+) AAACT(A/G)TATAC intron-variant
rs1000927591 -- 186,644,270(+) CTAAC(C/T)AAACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FETUB Gene

Variant ID Type Subtype PubMed ID
esv2759206 CNV loss 17122850
nsv4153 CNV insertion 18451855
nsv508974 CNV insertion 20534489
nsv525368 CNV loss 19592680

Variation tolerance for FETUB Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FETUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FETUB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FETUB Gene

Disorders for FETUB Gene

Relevant External Links for FETUB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FETUB

No disorders were found for FETUB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FETUB Gene

Publications for FETUB Gene

  1. Fetuin-B, a second member of the fetuin family in mammals. (PMID: 10947975) Olivier E … Salier JP (The Biochemical journal 2000) 2 3 4 60
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PMID: 15499407) Hsu SJ … Balmain A (Genome 2004) 3 4 60
  5. Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus. (PMID: 28183456) Kralisch S … Ebert T (Metabolism: clinical and experimental 2017) 3 60

Products for FETUB Gene

Sources for FETUB Gene

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