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Aliases for FETUB Gene

Aliases for FETUB Gene

  • Fetuin B 2 3
  • Fetuin-Like Protein IRL685 3 4
  • 16G2 3 4
  • Gugu 3 4
  • Fetuin-B 3
  • IRL685 3

External Ids for FETUB Gene

Previous GeneCards Identifiers for FETUB Gene

  • GC03P183129
  • GC03P187615
  • GC03P187760
  • GC03P187679
  • GC03P187840
  • GC03P186353
  • GC03P183767

Summaries for FETUB Gene

Entrez Gene Summary for FETUB Gene

  • The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FETUB Gene

FETUB (Fetuin B) is a Protein Coding gene. Diseases associated with FETUB include hantavirus pulmonary syndrome. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is AHSG.

UniProtKB/Swiss-Prot for FETUB Gene

  • Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Wiki entry for FETUB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FETUB Gene

Genomics for FETUB Gene

Regulatory Elements for FETUB Gene

Genomic Location for FETUB Gene

Start:
186,635,969 bp from pter
End:
186,653,141 bp from pter
Size:
17,173 bases
Orientation:
Plus strand

Genomic View for FETUB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FETUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FETUB Gene

Proteins for FETUB Gene

  • Protein details for FETUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM5-FETUB_HUMAN
    Recommended name:
    Fetuin-B
    Protein Accession:
    Q9UGM5
    Secondary Accessions:
    • B2RCW6
    • E9PG06
    • Q1RMZ0
    • Q5J876
    • Q6DK58
    • Q6GRB6
    • Q9Y6Z0

    Protein attributes for FETUB Gene

    Size:
    382 amino acids
    Molecular mass:
    42055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FETUB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FETUB Gene

Proteomics data for FETUB Gene at MOPED

Post-translational modifications for FETUB Gene

  • Glycosylation at Asn37, Asn136, and Asn182
  • Modification sites at PhosphoSitePlus

Other Protein References for FETUB Gene

Antibody Products

No data available for DME Specific Peptides for FETUB Gene

Domains for FETUB Gene

Protein Domains for FETUB Gene

Suggested Antigen Peptide Sequences for FETUB Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGM5

UniProtKB/Swiss-Prot:

FETUB_HUMAN :
  • Q9UGM5
Domain:
  • Contains 2 cystatin fetuin-B-type domains.
Family:
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with FETUB: view

No data available for Gene Families for FETUB Gene

Function for FETUB Gene

Molecular function for FETUB Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Ontology (GO) - Molecular Function for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity ISS --
genes like me logo Genes that share ontologies with FETUB: view

Phenotypes for FETUB Gene

MGI mutant phenotypes for FETUB:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FETUB: view

Animal Models for FETUB Gene

MGI Knock Outs for FETUB:

Animal Model Products

miRNA for FETUB Gene

miRTarBase miRNAs that target FETUB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FETUB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FETUB Gene

Localization for FETUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FETUB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FETUB Gene COMPARTMENTS Subcellular localization image for FETUB gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FETUB: view

Pathways for FETUB Gene

SuperPathways for FETUB Gene

No Data Available

Interacting Proteins for FETUB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265029%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000265029 for FETUB Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization ISS --
GO:0007339 binding of sperm to zona pellucida ISS --
GO:0008150 biological_process ND --
GO:0010951 negative regulation of endopeptidase activity ISS --
genes like me logo Genes that share ontologies with FETUB: view

No data available for Pathways by source for FETUB Gene

Transcripts for FETUB Gene

Unigene Clusters for FETUB Gene

Fetuin B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FETUB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FETUB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for FETUB Gene

GeneLoc Exon Structure for
FETUB
ECgene alternative splicing isoforms for
FETUB

Expression for FETUB Gene

mRNA expression in normal human tissues for FETUB Gene

mRNA differential expression in normal tissues according to GTEx for FETUB Gene

This gene is overexpressed in Liver (42.6).

Protein differential expression in normal tissues for FETUB Gene

This gene is overexpressed in Serum (26.9), Plasma (14.9), and Synovial fluid (13.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FETUB Gene

SOURCE GeneReport for Unigene cluster for FETUB Gene Hs.81073

mRNA Expression by UniProt/SwissProt for FETUB Gene

Q9UGM5-FETUB_HUMAN
Tissue specificity: Liver and testis
genes like me logo Genes that share expressions with FETUB: view

Expression partners for FETUB Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FETUB Gene

Orthologs for FETUB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FETUB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FETUB 35
  • 77.42 (n)
  • 66.67 (a)
FETUB 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FETUB 35
  • 79.93 (n)
  • 70.03 (a)
FETUB 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fetub 35
  • 74.79 (n)
  • 66.39 (a)
Fetub 16
Fetub 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FETUB 35
  • 98.43 (n)
  • 97.38 (a)
FETUB 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fetub 35
  • 72.8 (n)
  • 64.31 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FETUB 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FETUB 35
  • 53.78 (n)
  • 40.06 (a)
FETUB 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FETUB 36
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fetub 35
  • 46.77 (n)
  • 34.93 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563738 35
  • 53.78 (n)
  • 38.12 (a)
fetub 36
  • 23 (a)
OneToMany
FETUB (2 of 3) 36
  • 26 (a)
OneToMany
FETUB (3 of 3) 36
  • 30 (a)
OneToMany
Species with no ortholog for FETUB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FETUB Gene

ENSEMBL:
Gene Tree for FETUB (if available)
TreeFam:
Gene Tree for FETUB (if available)

Paralogs for FETUB Gene

Paralogs for FETUB Gene

Selected SIMAP similar genes for FETUB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FETUB: view

Variants for FETUB Gene

Sequence variations from dbSNP and Humsavar for FETUB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7999 - 186,652,561(-) TTTCT(C/T)TGGGG reference, missense
rs1047115 -- 186,640,577(-) ACATC(G/T)GAGTC reference, synonymous-codon, utr-variant-5-prime
rs1131364 -- 186,652,544(-) AGGAC(A/C)ACCAG reference, synonymous-codon
rs1447669 -- 186,648,787(+) AATTT(A/C)ATTTT intron-variant
rs2121751 -- 186,647,248(+) tatcc(A/T)tctat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FETUB Gene

Variant ID Type Subtype PubMed ID
nsv508974 CNV Insertion 20534489
dgv1541e1 CNV Complex 17122850
nsv4153 CNV Insertion 18451855
nsv525368 CNV Loss 19592680
nsv878068 CNV Gain 21882294
essv25049 CNV CNV 17122850

Relevant External Links for FETUB Gene

HapMap Linkage Disequilibrium report
FETUB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FETUB Gene

Disorders for FETUB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FETUB Gene in MalaCards »

(1) Diseases for FETUB Gene including...

(1) University of Copenhagen DISEASES for FETUB Gene

genes like me logo Genes that share disorders with FETUB: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for FETUB Gene

Publications for FETUB Gene

  1. Fetuin-B, a second member of the fetuin family in mammals. (PMID: 10947975) Olivier E. … Salier J.-P. (Biochem. J. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PMID: 15499407) Hsu S.J. … Balmain A. (Genome 2004) 3 4
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  5. Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. (PMID: 16797392) Coen G. … Bonucci E. (Am. J. Kidney Dis. 2006) 3

Products for FETUB Gene

Sources for FETUB Gene

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