FETUB Gene
protein-coding GIFtS: 50
GCID: GC03P186353
|
|
fetuin B
| |
Aliases
for FETUB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fetuin B1 2 | | Fetuin-Like Protein IRL6852 3 | | 16G22 3 | | Gugu2 3 | | IRL6852 | | Fetuin-B1 |
Export aliases for FETUB gene to outside databasesPrevious GC identifers: GC03P183129 GC03P187615 GC03P187760 GC03P187679 GC03P187840 GC03P183767 |
Summaries
for FETUB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FETUB:
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteineprotease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and boneresorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation.This protein may be secreted by cells. (provided by RefSeq, Jul 2008)
Gene Wiki entry for FETUB (Fetuin-B)
|
Genomic Views
for FETUB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FETUB gene promoter:
E2F-3a E2F-4 E2F-5 AML1a E2F-2 E2F-1 E2F FOXO4 Chx10 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for FETUB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FETUB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27.3FETUB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P186353: view genomic region
(about GC identifiers)
Start:
|
186,353,758 bp from pter |
End:
|
186,370,930 bp from pter |
Size:
|
17,173 bases |
Orientation:
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plus strand |
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Proteins
for FETUB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5 (See
protein sequence)Recommended Name: Fetuin-B precursor Size: 382 amino acids; 42055 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2RCW6 Q1RMZ0 Q6DK58 Q6GRB6 Q9Y6Z0Explore the universe of human proteins at neXtProt for FETUB: NX_Q9UGM5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGM5
FETUB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055190.2
ENSEMBL proteins: ENSP00000404288 ENSP00000396581 ENSP00000265029 ENSP00000371569 ENSP00000393851 ENSP00000405438 ENSP00000371571 ENSP00000443704
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
FETUB for ontologies About GeneDecksing
FETUB Antibody Products:
Assay Products for FETUB: |
Protein
Domains /
Families
for FETUB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FETUB for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UGM5ProtoNet protein and cluster: Q9UGM5 1 Blocks protein family: IPB000010 Cysteine protease inhibitor
UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5Similarity: Belongs to the fetuin familySimilarity: Contains 2 cystatin fetuin-B-type domains |
Function
for FETUB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FETUB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FETUB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FETUB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FETUB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FETUB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- |
FETUB for ontologies About GeneDecksing
|
Pathways & Interactions
for FETUB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FETUB
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
FETUB for ontologies About GeneDecksing
|
Drugs & Compounds
for FETUB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FETUB
Search CenterWatch for drugs/clinical trials and news about FETUB
|
Transcripts
for FETUB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FETUB gene: NM_014375.2 Unigene Cluster for FETUB: Fetuin B Hs.81073 [show with all ESTs]Unigene Representative Sequence: NM_0143759 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450521 ENST00000431018 ENST00000265029(uc010hyq.3 uc003fqn.3 uc010hyr.3 uc003fqp.4)
ENST00000382134 ENST00000435961(uc010hys.3) ENST00000420570 ENST00000488561
ENST00000382136 ENST00000539949(uc011brz.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FETUB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FETUB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FETUB (NM_014375) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FETUB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FETUB |
Additional cDNA sequence: AB017551.1 AF534529.1 AJ242928.1 AK303859.1 AK309647.1 AK315309.1 AY373820.1 AY373821.1 BC069670.1 BC069820.1 BC074734.2 BC114616.1 4 DOTS entries: DT.454206 DT.95260104 DT.95260105 DT.92418729 24/89 AceView cDNA sequences (see all 89): CR603548 CB156988 BC069670 AB017551 CB163984 N78259 BC069820 BX431933 T61011 N49312 CB163209 AV651998 BX340570 AA703251 AF534529 AA620768 NM_014375 H77986 AA909680 CB162763 AV646205 N70226 BE143060 BC074734
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FETUB About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FETUB
|
Expression
for FETUB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FETUB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAAAGATA
About this image
See FETUB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FETUB
SOURCE GeneReport for Unigene cluster: Hs.81073
UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5Tissue specificity: Liver and testis
SABiosciences Custom PCR Arrays for FETUB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FETUB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FETUB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FETUB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FETUB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FETUB |
Orthologs
for FETUB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FETUB gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for FETUB (if available)
TreeFam Gene Tree for FETUB (if available) |
Paralogs
for FETUB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FETUB gene
- AHSG2
2 SIMAP similar genes for FETUB using alignment to 7 protein entries: FETUB_HUMAN (see all proteins):GUGU KNG1
FETUB for paralogs About GeneDecksing
|
Genomic Variants
for FETUB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FETUB (186353758 - 186370930 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FETUB
3 CNVs: 2488 3467 36114 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FETUB |
|
Disorders
/ Diseases
for FETUB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FETUB for disorders About GeneDecksing
OMIM gene information: 605954
OMIM disorders: --
3  diseases for FETUB: About MalaCardshantavirus pulmonary syndrome renal osteodystrophy immunodeficiency
1 disease from the University of Copenhagen DISEASES database for FETUB:Hantavirus pulmonary syndrome Export disorders for FETUB gene to outside databases
|
Publications
for FETUB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FETUB gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FETUB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fetuin-B, a second member of the fetuin family in mammals. (PubMed id 10947975)1, 2, 3 Olivier E....Salier J.-P. (2000)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PubMed id 15499407)1, 2 Hsu S.J.... Balmain A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (2012)
- Downregulation of fetuin-B and zinc-a2-glycoprotein is linked to impaired fatty acid metabolism in liver cells. (PubMed id 22739111)1 Choi J.W....Yun J.W. (2012)
- Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. (PubMed id 16797392)1 Coen G....Bonucci E. (2006)
- Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. (PubMed id 15280384)1 Wajih N....Wallin R. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A. (PubMed id 12943536)1 Denecke B....Jahnen-Dechent W. (2003)
|
External Searches for FETUB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FETUB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FETUB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FETUB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FETUB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FETUB gene:
Search GeneIP for patents involving FETUB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FETUB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FETUB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FETUB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FETUB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FETUB | | OriGene 3'-UTR Clone for FETUB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FETUB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FETUB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FETUB | | OriGene Custom Protein Services for FETUB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FETUB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FETUB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FETUB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FETUB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FETUB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FETUB |
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| |  |  |  |  | | | | |
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 | | | FETUB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FETUB |
|  |  |  | | | | ThermoFisher Antibodies for FETUB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FETUB |
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