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Aliases for FETUB Gene

Aliases for FETUB Gene

  • Fetuin B 2 3 5
  • Fetuin-Like Protein IRL685 3 4
  • 16G2 3 4
  • Gugu 3 4
  • Fetuin-B 3
  • IRL685 3

External Ids for FETUB Gene

Previous GeneCards Identifiers for FETUB Gene

  • GC03P183129
  • GC03P187615
  • GC03P187760
  • GC03P187679
  • GC03P187840
  • GC03P186353
  • GC03P183767

Summaries for FETUB Gene

Entrez Gene Summary for FETUB Gene

  • The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FETUB Gene

FETUB (Fetuin B) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is AHSG.

UniProtKB/Swiss-Prot for FETUB Gene

  • Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Wiki entry for FETUB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FETUB Gene

Genomics for FETUB Gene

Regulatory Elements for FETUB Gene

Enhancers for FETUB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F186640 0.7 ENCODE 17.3 +4.7 4724 1.1 ATF3 CEBPA HNF4G REST NR2F2 FETUB HRG
GH03F186669 0.5 ENCODE 11.3 +34.0 33979 1.3 TBP CEBPG FOSL1 ZNF316 FOS TRIM24 NFE2 NFE2L2 HLF MAFG FETUB KNG1 AHSG HRG LOC100533663
GH03F186597 0.9 ENCODE 11 -36.2 -36182 3.4 PKNOX1 MLX ZNF133 ZFP64 ARID4B DMAP1 ZNF48 YY1 PPARG KAT8 FETUB KNG1 HRG ENSG00000283390 AHSG
GH03F186752 1.1 Ensembl ENCODE 10.6 +118.3 118306 3.9 ARID4B BRCA1 YY1 ZNF121 FOS REST KAT8 MAFF SMARCA4 STAT3 KNG1 MIR1248 EIF4A2 ENSG00000200418 SNORA63 SNORA81 RFC4 FETUB ENSG00000231724 AHSG
GH03F186757 0.2 ENCODE 10.6 +121.9 121932 1.5 GATA3 ZFHX2 PKNOX1 ATF3 PBX2 IKZF1 SPI1 KNG1 MIR1248 SNORA63 SNORA81 EIF4A2 ENSG00000200418 RFC4 FETUB AHSG ENSG00000231724
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FETUB on UCSC Golden Path with GeneCards custom track

Genomic Location for FETUB Gene

Chromosome:
3
Start:
186,635,832 bp from pter
End:
186,653,141 bp from pter
Size:
17,310 bases
Orientation:
Plus strand

Genomic View for FETUB Gene

Genes around FETUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FETUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FETUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FETUB Gene

Proteins for FETUB Gene

  • Protein details for FETUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM5-FETUB_HUMAN
    Recommended name:
    Fetuin-B
    Protein Accession:
    Q9UGM5
    Secondary Accessions:
    • B2RCW6
    • E9PG06
    • Q1RMZ0
    • Q5J876
    • Q6DK58
    • Q6GRB6
    • Q9Y6Z0

    Protein attributes for FETUB Gene

    Size:
    382 amino acids
    Molecular mass:
    42055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FETUB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FETUB Gene

Post-translational modifications for FETUB Gene

  • Glycosylation at Asn 37, Asn 136, Asn 182, Thr 289, and Thr 292
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for FETUB

No data available for DME Specific Peptides for FETUB Gene

Domains & Families for FETUB Gene

Gene Families for FETUB Gene

Protein Domains for FETUB Gene

Suggested Antigen Peptide Sequences for FETUB Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGM5

UniProtKB/Swiss-Prot:

FETUB_HUMAN :
  • Contains 2 cystatin fetuin-B-type domains.
  • Belongs to the fetuin family.
Domain:
  • Contains 2 cystatin fetuin-B-type domains.
Family:
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with FETUB: view

Function for FETUB Gene

Molecular function for FETUB Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Ontology (GO) - Molecular Function for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004857 enzyme inhibitor activity IEA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity ISS,IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with FETUB: view
genes like me logo Genes that share phenotypes with FETUB: view

Animal Models for FETUB Gene

MGI Knock Outs for FETUB:

Animal Model Products

  • Taconic Biosciences Mouse Models for FETUB

miRNA for FETUB Gene

miRTarBase miRNAs that target FETUB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FETUB Gene

Localization for FETUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FETUB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FETUB Gene COMPARTMENTS Subcellular localization image for FETUB gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IBA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FETUB: view

Pathways & Interactions for FETUB Gene

SuperPathways for FETUB Gene

No Data Available

Interacting Proteins for FETUB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265029%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9UGM5-FETUB_HUMAN ENSP00000265029 for FETUB Gene via IID STRING

Gene Ontology (GO) - Biological Process for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization ISS --
GO:0007339 binding of sperm to zona pellucida ISS,IBA --
GO:0008150 biological_process ND --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity ISS --
genes like me logo Genes that share ontologies with FETUB: view

No data available for Pathways by source and SIGNOR curated interactions for FETUB Gene

Transcripts for FETUB Gene

Unigene Clusters for FETUB Gene

Fetuin B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FETUB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for FETUB Gene

GeneLoc Exon Structure for
FETUB
ECgene alternative splicing isoforms for
FETUB

Expression for FETUB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FETUB Gene

mRNA differential expression in normal tissues according to GTEx for FETUB Gene

This gene is overexpressed in Liver (x42.6).

Protein differential expression in normal tissues from HIPED for FETUB Gene

This gene is overexpressed in Serum (26.9), Plasma (14.9), and Synovial fluid (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FETUB Gene



Protein tissue co-expression partners for FETUB Gene

NURSA nuclear receptor signaling pathways regulating expression of FETUB Gene:

FETUB

SOURCE GeneReport for Unigene cluster for FETUB Gene:

Hs.81073

mRNA Expression by UniProt/SwissProt for FETUB Gene:

Q9UGM5-FETUB_HUMAN
Tissue specificity: Liver and testis.
genes like me logo Genes that share expression patterns with FETUB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FETUB Gene

Orthologs for FETUB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FETUB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FETUB 34 35
  • 98.43 (n)
dog
(Canis familiaris)
Mammalia FETUB 34 35
  • 79.93 (n)
cow
(Bos Taurus)
Mammalia FETUB 34 35
  • 77.42 (n)
mouse
(Mus musculus)
Mammalia Fetub 34 16 35
  • 74.79 (n)
rat
(Rattus norvegicus)
Mammalia Fetub 34
  • 72.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FETUB 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FETUB 34 35
  • 53.78 (n)
lizard
(Anolis carolinensis)
Reptilia FETUB 35
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fetub 34
  • 46.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563738 34
  • 53.78 (n)
FETUB (3 of 3) 35
  • 30 (a)
OneToMany
FETUB (2 of 3) 35
  • 26 (a)
OneToMany
fetub 35
  • 23 (a)
OneToMany
Species where no ortholog for FETUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FETUB Gene

ENSEMBL:
Gene Tree for FETUB (if available)
TreeFam:
Gene Tree for FETUB (if available)

Paralogs for FETUB Gene

Paralogs for FETUB Gene

(1) SIMAP similar genes for FETUB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FETUB: view

Variants for FETUB Gene

Sequence variations from dbSNP and Humsavar for FETUB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1047115 -- 186,640,577(-) ACATC(G/T)GAGTC intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs10618470 -- 186,650,180(+) GGGGG(-/GGG)TAAAT intron-variant
rs111266998 -- 186,651,491(+) AATAT(G/T)GTCCT intron-variant, nc-transcript-variant
rs111368341 -- 186,640,072(+) GTGGC(C/G)AAGGA intron-variant, upstream-variant-2KB
rs111434312 -- 186,644,168(+) CTTAT(A/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FETUB Gene

Variant ID Type Subtype PubMed ID
esv2759206 CNV loss 17122850
nsv4153 CNV insertion 18451855
nsv508974 CNV insertion 20534489
nsv525368 CNV loss 19592680

Variation tolerance for FETUB Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FETUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FETUB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FETUB Gene

Disorders for FETUB Gene

Relevant External Links for FETUB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FETUB

No disorders were found for FETUB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FETUB Gene

Publications for FETUB Gene

  1. Fetuin-B, a second member of the fetuin family in mammals. (PMID: 10947975) Olivier E. … Salier J.-P. (Biochem. J. 2000) 2 3 4 64
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PMID: 15499407) Hsu S.J. … Balmain A. (Genome 2004) 3 4 64
  5. The serum protein fetuin-B is involved in the development of acute myocardial infarction. (PMID: 25671698) Jung S.H. … Kim B. (Clin. Sci. 2015) 3 64

Products for FETUB Gene

  • Cloud-Clone Corp. Antibodies for FETUB
  • Cloud-Clone Corp. Proteins for FETUB
  • Cloud-Clone Corp Assay Kits for FETUB

Sources for FETUB Gene

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