Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FETUB Gene

protein-coding   GIFtS: 53
GCID: GC03P186353

Fetuin B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fetuin B1 2
Fetuin-Like Protein IRL6852 3
16G22 3
Gugu2 3
IRL6852
fetuin-B2

External Ids:    HGNC: 36581   Entrez Gene: 269982   Ensembl: ENSG000000905127   OMIM: 6059545   UniProtKB: Q9UGM53   

Export aliases for FETUB gene to outside databases

Previous GC identifers: GC03P183129 GC03P187615 GC03P187760 GC03P187679 GC03P187840 GC03P183767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FETUB Gene:
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine
protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone
resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic
inflammation. This protein may be secreted by cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for FETUB Gene:
FETUB (fetuin B) is a protein-coding gene. Diseases associated with FETUB include hantavirus pulmonary syndrome, and renal osteodystrophy. GO annotations related to this gene include metalloendopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is AHSG.

UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5
Function: Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida
hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates
the cleavage of ZP2 and triggers zona pellucida hardening (By similarity)

Gene Wiki entry for FETUB (Fetuin-B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FETUB gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   E2F-1   E2F   FOXO4   Chx10   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFETUB promoter sequence
   Search Chromatin IP Primers for FETUB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FETUB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

FETUB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FETUB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186353:  view genomic region     (about GC identifiers)

Start:
186,353,758 bp from pter      End:
186,370,930 bp from pter
Size:
17,173 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5 (See protein sequence)
Recommended Name: Fetuin-B precursor  
Size: 382 amino acids; 42055 Da
Developmental stage: 2-fold increase toward the end of the menstrual cycle
Secondary accessions: B2RCW6 E9PG06 Q1RMZ0 Q5J876 Q6DK58 Q6GRB6 Q9Y6Z0
Alternative splicing: 2 isoforms:  Q9UGM5-1   Q9UGM5-2   

Explore the universe of human proteins at neXtProt for FETUB: NX_Q9UGM5

Explore proteomics data for FETUB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn37, Asn136, Asn182
  • Modification sites at PhosphoSitePlus

  • See FETUB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055190.2  
    ENSEMBL proteins: 
     ENSP00000396581   ENSP00000404288   ENSP00000371569   ENSP00000265029   ENSP00000393851  
     ENSP00000405438   ENSP00000371571   ENSP00000443704  

    FETUB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FETUB (Fetuin B)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FETUB
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FETUB
    GenScript Custom Purified and Recombinant Proteins Services for FETUB
    Novus Biologicals FETUB Proteins
    Novus Biologicals FETUB Lysate
    Sino Biological Recombinant Protein for FETUB
    Sino Biological Cell Lysate for FETUB
    ProSpec Recombinant Protein for FETUB
    Cloud-Clone Corp. Proteins for FETUB

    FETUB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FETUB
    R&D Systems Antibodies for FETUB (Fetuin B)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FETUB
    Novus Biologicals FETUB Antibodies
    Abcam antibodies for FETUB
    Cloud-Clone Corp. Antibodies for FETUB
    ThermoFisher Antibody for FETUB
    LSBio Antibodies in human, mouse, rat for FETUB

    FETUB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FETUB
    R&D Systems ELISAs for FETUB (Fetuin B)         (see all)
    GenScript Custom Assay Services for FETUB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FETUB
    Cloud-Clone Corp. CLIAs for FETUB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR025764 Cystatin_Fetuin_B
     IPR001363 Prot_inh_fetuin_CS
     IPR000010 Prot_inh_cystat

    Graphical View of Domain Structure for InterPro Entry Q9UGM5

    ProtoNet protein and cluster: Q9UGM5

    1 Blocks protein domain: IPB000010 Cysteine protease inhibitor

    UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5
    Similarity: Belongs to the fetuin family
    Similarity: Contains 2 cystatin fetuin-B-type domains


    FETUB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FETUB_HUMAN, Q9UGM5
    Function: Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida
    hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates
    the cleavage of ZP2 and triggers zona pellucida hardening (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0008191metalloendopeptidase inhibitor activity ISS--
         
    FETUB for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fetub):
     reproductive system 

    FETUB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fetubtm1Wja for FETUB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FETUB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FETUB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FETUB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FETUB

    miRNA
    Products:
        
    miRTarBase miRNAs that target FETUB:
    hsa-mir-148b-3p (MIRT019366)

    Block miRNA regulation of human, mouse, rat FETUB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FETUB
    SwitchGear 3'UTR luciferase reporter plasmidFETUB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FETUB
    Predesigned siRNA for gene silencing in human, mouse, rat FETUB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FETUB

    Clone
    Products:
         
    OriGene clones in human, mouse for FETUB (see all 7)
    OriGene ORF clones in mouse, rat for FETUB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FETUB (NM_014375)
    Sino Biological Human cDNA Clone for FETUB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FETUB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FETUB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FETUB
    Browse ESI BIO Cell Lines and PureStem Progenitors for FETUB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FETUB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FETUB_HUMAN, Q9UGM5: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    FETUB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FETUB
    Interactions:

        Search GeneGlobe Interaction Network for FETUB

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007338single fertilization ISS--
    GO:0007339binding of sperm to zona pellucida ISS--
    GO:0008150biological_process ND--
    GO:0010951negative regulation of endopeptidase activity ISS--

    FETUB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FETUB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FETUB gene: 
    NM_014375.2  

    Unigene Cluster for FETUB:

    Fetuin B
    Hs.81073  [show with all ESTs]
    Unigene Representative Sequence: NM_014375
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431018 ENST00000450521 ENST00000382134 ENST00000265029(uc010hyq.3 uc003fqn.3 uc010hyr.3 uc003fqp.4)
    ENST00000435961(uc010hys.3) ENST00000420570 ENST00000488561 ENST00000382136
    ENST00000539949(uc011brz.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FETUB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FETUB
    SwitchGear 3'UTR luciferase reporter plasmidFETUB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FETUB
    Predesigned siRNA for gene silencing in human, mouse, rat FETUB
    Clone
    Products:
         
    OriGene clones in human, mouse for FETUB (see all 7)
    OriGene ORF clones in mouse, rat for FETUB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FETUB (NM_014375)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FETUB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FETUB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FETUB
    OriGene qSTAR qPCR primer pairs in human, mouse for FETUB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FETUB
      QuantiTect SYBR Green Assays in human, mouse, rat FETUB
      QuantiFast Probe-based Assays in human, mouse, rat FETUB

    Additional mRNA sequence: 

    AB017551.1 AF534529.1 AJ242928.1 AK303859.1 AK309647.1 AK315309.1 AY373820.1 AY373821.1 
    BC069670.1 BC069820.1 BC074734.2 BC114616.1 

    4 DOTS entries:

    DT.454206  DT.95260104  DT.95260105  DT.92418729 

    Selected AceView cDNA sequences (see all 89):

    CR603548 AB017551 BC069670 N78259 CB156988 CB163984 BC069820 T61011 
    BX431933 BX390632 AV646205 H70786 AA703251 N70226 H91229 AA620768 
    H77986 NM_014375 AV651998 AA909680 BX340570 BC074734 N49312 AJ242928 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FETUB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                      
    SP2:                                                      


    ECgene alternative splicing isoforms for FETUB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FETUB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAAAGATA
    FETUB Expression
    About this image

    FETUB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FETUB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.81073

    UniProtKB/Swiss-Prot: FETUB_HUMAN, Q9UGM5
    Tissue specificity: Liver and testis

        Custom PCR Arrays for FETUB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FETUB
    OriGene qSTAR qPCR primer pairs in human, mouse for FETUB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FETUB
    QuantiTect SYBR Green Assays in human, mouse, rat FETUB
    QuantiFast Probe-based Assays in human, mouse, rat FETUB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FETUB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FETUB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fetub1 , 5 fetuin beta1, 5 74.79(n)1
    66.39(a)1
      16 (13.76 cM)5
    590831  NM_021564.21  NP_067539.11 
     229183825 
    chicken
    (Gallus gallus)
    Aves FETUB1 fetuin B 53.78(n)
    40.06(a)
      395404  NM_001277408.1  NP_001264337.1 
    lizard
    (Anolis carolinensis)
    Reptilia FETUB6
    fetuin B
    28(a)
    1 ↔ 1
    GL343321.1(198439-212892)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fetub1 fetuin B 46.77(n)
    34.93(a)
      496992  XM_002937840.2  XP_002937886.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5637381 Fetuin-B-like 53.78(n)
    38.12(a)
      563738  NM_001045024.1  NP_001038489.1 


    ENSEMBL Gene Tree for FETUB (if available)
    TreeFam Gene Tree for FETUB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FETUB gene
    AHSG2  
    1 SIMAP similar gene for FETUB using alignment to 6 protein entries:     FETUB_HUMAN (see all proteins):
    GUGU

    FETUB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FETUB (see all 368)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492607971,2
    --186356158(+) ACAGGC/TAGGTG 1 -- us2k10--------
    rs1902159421,2
    --186356276(+) AGAGGA/TGGAAT 1 -- us2k10--------
    rs1809023781,2
    --186356301(+) GCCTGA/GCACCA 1 -- us2k10--------
    rs622925681,2
    F--186356330(+) TGCTTC/TCTCTC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1841958931,2
    --186356369(+) AGAAGC/GCCAGC 1 -- us2k10--------
    rs1887354631,2
    --186356414(+) CATAAA/GTGGTG 1 -- us2k10--------
    rs730614511,2
    C,F--186356425(+) GTGCAC/TGATTT 1 -- us2k12Minor allele frequency- T:0.02WA 120
    rs1393052021,2
    --186356481(+) TTAGTC/TGCACT 1 -- us2k10--------
    rs1441718121,2
    --186356490(+) CTCATA/GGCCTT 1 -- us2k10--------
    rs1812065281,2
    C--186356493(+) ATGGCA/CTTCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FETUB (186353758 - 186370930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FETUB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508974CNV Insertion20534489
    nsv4153CNV Insertion18451855
    nsv525368CNV Loss19592680
    nsv878068CNV Gain21882294
    essv25049CNV CNV17122850
    dgv1541e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FETUB
    DNA2.0 Custom Variant and Variant Library Synthesis for FETUB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605954    OMIM disorders: --

    3 diseases for FETUB:    
    About MalaCards
    hantavirus pulmonary syndrome    renal osteodystrophy    coronary artery disease

    1 disease from the University of Copenhagen DISEASES database for FETUB:
    Hantavirus pulmonary syndrome

    FETUB for disorders           About GeneDecksing


    Export disorders for FETUB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FETUB gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FETUB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fetuin-B, a second member of the fetuin family in mammals. (PubMed id 10947975)1, 2, 3 Olivier E....Salier J.-P. (Biochem. J. 2000)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PubMed id 15499407)1, 2 Hsu S.J.... Balmain A. (Genome 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. Fetuin-B, a liver-derived plasma protein is essential for fertilization. (PubMed id 23562279)2 Dietzel E....Jahnen-Dechent W. (Dev. Cell 2013)
    7. Downregulation of fetuin-B and zinc-I+2-glycoprotein is linked to impaired fatty acid metabolism in liver cells. (PubMed id 22739111)1 Choi J.W....Yun J.W. (Cell. Physiol. Biochem. 2012)
    8. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (Am. J. Hum. Genet. 2012)
    9. Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. (PubMed id 16797392)1 Coen G....Bonucci E. (Am. J. Kidney Dis. 2006)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26998 HGNC: 3658 AceView: FETUB Ensembl:ENSG00000090512 euGenes: HUgn26998
    ECgene: FETUB H-InvDB: FETUB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FETUB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FETUB gene:
    Search GeneIP for patents involving FETUB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FETUB
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FETUB (Fetuin B)   Browse Cell Culture Products  
     ELISAs for FETUB (Fetuin B)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FETUB (Fetuin B)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for FETUB (Fetuin B)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FETUB  
     OriGene qPCR primer pairs and template standards for FETUB   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FETUB  
     OriGene qSTAR qPCR primer pairs in human, mouse for FETUB   OriGene Purified Protein for FETUB  
     OriGene ORF clones in mouse, rat for FETUB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FETUB   OriGene Custom Protein Services for FETUB  

     
     
     Block miRNA regulation of human, mouse, rat FETUB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FETUB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FETUB Predesigned siRNA for gene silencing in human, mouse, rat FETUB
     QuantiFast Probe-based Assays in human, mouse, rat FETUB QuantiTect SYBR Green Assays in human, mouse, rat FETUB
     Custom PCR Arrays for FETUB Search Chromatin IP Primers for FETUB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FETUB  Search GeneGlobe Interaction Network for FETUB
     Regulatory tfbs in FETUB promoter
     GenScript Custom Purified and Recombinant Proteins Services for FETUB GenScript cDNA clones with any tag delivered in your preferred vector for FETUB
     GenScript Custom Assay Services for FETUB GenScript Custom overexpressing Cell Line Services for FETUB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FETUB
     Proteins for FETUB
     Cell Lysates for FETUB
     cDNA Clones for FETUB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FETUB antibodies
     FETUB proteins
     FETUB lysates
     Antibodies for FETUB
     See all of Abcam's Antibodies, Kits and Proteins for FETUB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FETUB
     Proteins for FETUB
     Antibodies for FETUB
     ELISAs for FETUB
     CLIAs for FETUB



     Browse ESI BIO Cell Lines and PureStem Progenitors for FETUB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FETUB
     SwitchGear 3'UTR luciferase reporter plasmids for FETUB
     SwitchGear Promoter luciferase reporter plasmids for FETUB
     ThermoFisher Antibody for FETUB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FETUB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FETUB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FETUB
     LSBio Antibodies in human, mouse, rat for FETUB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FETUB gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4