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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FES Gene

protein-coding GIFtS: 72
GCID: GC15P091426

feline sarcoma oncogene

(Previous name: feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami...)

Explore 18 diseases affiliated with
FES via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Feline Sarcoma Oncogene¹ ²		P93c-Fes¹
FPS¹ ² ³		EC 2.7.10.2³ ⁸
Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog¹ ²		Oncogene FES, Feline Sarcoma Virus²
Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog² ³		Proto-Oncogene Tyrosine-Protein Kinase Fes/Fps²
Proto-Oncogene C-Fes² ³		Tyrosine-Protein Kinase Fes/Fps²
Proto-Oncogene C-Fps² ³		EC 2.7.10⁸

External Ids:	HGNC: 3657¹	Entrez Gene: 2242²	Ensembl: ENSG00000182511⁷	OMIM: 190030⁵	UniProtKB: P07332³

Export aliases for FES gene to outside databases

Previous GC identifers: GC15P087616 GC15P084868 GC15P089014 GC15P089157 GC15P089230 GC15P067539

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FES:

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities.

The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of

cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in

patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor

and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different

isoforms.(provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of

the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity

immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor

and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a

role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a

role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and

down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28

Gene Wiki entry for FES (Feline sarcoma oncogene)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FES gene promoter:
AP-1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FES promoter sequence

Search SABiosciences Chromatin IP Primers for FES

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FES

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25-qter

FES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FES gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P091426: view genomic region (about GC identifiers)

Start:	91,426,925 bp from pter	End:	91,439,006 bp from pter
Size:	12,082 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FES_HUMAN, P07332 (See protein sequence)

Recommended Name: Tyrosine-protein kinase Fes/Fps

Size: 822 amino acids; 93497 Da

Subunit: Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts

(via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts

with FLT3. Interacts (via FCH domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules

Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein;

Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the

cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity.

Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in

polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the

cytoplasm and at the cell periphery

Miscellaneous: Cellular homolog of retroviral oncogenes. In contrast to the viral oncoproteins, the kinase activity of

cellular FSP/FES is tightly regulated, and the kinase is inactive in normal cells in the absence of activating stimuli

(PubMed:15485904)

6/7 PDB 3D structures from and Proteopedia for FES (see all 7):

1WQU (3D)

2DCR (3D)

3BKB (3D)

3CBL (3D)

3CD3 (3D)

4DYL (3D)

Secondary accessions: B2R6E6 B4DUD0 E9PC94 E9PC95 Q2VXS7 Q2VXS8 Q2VXT0 Q6GTU5

Alternative splicing: 4 isoforms: P07332-1 P07332-2 P07332-3 P07332-4

Explore the universe of human proteins at neXtProt for FES: NX_P07332

Post-translational modifications:

Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07332

4/22 DME Specific Peptides for FES (P07332) (see all 22)

RDLAARN

KWTAPEA

KAKFLQEA

TKKSGVVL

FES Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001137255.1 NP_001137256.1 NP_001137257.1 NP_001996.1

ENSEMBL proteins:

ENSP00000410477 ENSP00000331504 ENSP00000454146 ENSP00000414629 ENSP00000454089

ENSP00000377839 ENSP00000392696 ENSP00000435811 ENSP00000395425 ENSP00000377837

ENSP00000400868 ENSP00000409915

Reactome Protein details: P07332
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant FES Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): FES OriGene Custom Protein Services for FES
	GenScript Custom Purified and Recombinant Proteins Services for FES
	Novus Biologicals FES Proteins Novus Biologicals FES Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FES

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11339827
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005925	focal adhesion	IDA	18046454
GO:0015630	microtubule cytoskeleton	IDA	15485904

FES for ontologies About GeneDecksing

FES Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FES
	Cell Signaling Technology (CST) Antibodies for FES
	OriGene Antibodies: FES OriGene Custom Antibody Services for FES
	GenScript Superior Antibodies for FES
	Novus Biologicals FES Antibodies
	Abcam antibodies for FES
	Uscn Antibodies for FES
	ThermoFisher Antibodies for FES

Assay Products for FES:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FES
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FES

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FES for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR017441 Protein_kinase_ATP_BS

IPR001060 FCH

IPR011009 Kinase-like_dom

IPR016250 Tyr_kinase_non-rcpt_Fes_subgr

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P07332

ProtoNet protein and cluster: P07332

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001060 Cdc15/Fes/CIP4

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Domain: The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization and

probably also interaction with other proteins

Domain: The N-terminal region including the first coiled coil domain mediates interaction with

phosphoinositide-containing membranes

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily

Similarity: Contains 1 FCH domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of

the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity

immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor

and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a

role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a

role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and

down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme regulation: Kinase activity is tightly regulated. Activated in response to signaling from a cell surface

receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713.

Present in an inactive form in the absence of activating stimuli

Genatlas biochemistry entry for FES:

feline sarcoma viral (v-fes) oncogene;Fujinami avian sarcoma viral (v-fps) oncogene homolog

Enzyme Numbers (IUBMB): EC 2.7.10.2¹ ² EC 2.7.10²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): FES Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FES
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FES:
		hsa-miR-194* hsa-miR-3916 hsa-miR-3125
		SwitchGear 3'UTR luciferase reporter plasmid: FES 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FES (see all 7) OriGene shRNA RFP: FES OriGene siRNA: FES
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FES

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FES

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FES (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FES (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): FES (NM_001143783)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FES
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FES

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FES
		Search LifeMap BioReagents cell lines for FES

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FES

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004713	protein tyrosine kinase activity	IDA	11509660
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IDA	15485904
GO:0005524	ATP binding	IEA	--
GO:0034987	immunoglobulin receptor binding	IDA	19001085

FES for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for FES:

Decreased substrate adherent c

Decreased telomerase activity

Increased cell death HMECs cel

Weaker migration

Animal Models:
Mouse knock-outs for FES: Fes^tm2Mcs Fes^tm2Pag Fes^tm1Mcs
15/16 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fes) (see all 16):

cardiovascular system	cellular	craniofacial	digestive/alimentary	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	mortality/aging
muscle	nervous system	normal	reproductive system	tumorigenesis

FES for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	1.00			CRMPs in Sema3A signaling	0.36
	Sema3A PAK dependent Axon repulsion	0.45

Immune response_IL-4 signaling pathway

Immune response_IL-4 signaling pathway

1.00

Immune response IL-4 signaling pathway

0.98

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Development_EPO-induced Jak-STAT pathway

Development EPO-induced Jak-STAT pathway

1.00

Development_EPO-induced Jak-STAT pathway

1.00

Neurophysiological process Receptor-mediated axon growth repulsion

Neurophysiological process Receptor-mediated axon growth repulsion

1.00

Neurophysiological process_Receptor-mediated axon growth repulsion

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for FES

	Neurophysiological process Receptor-mediated axon growth repulsion
	Development EPO-induced Jak-STAT pathway
	Immune response IL-4 signaling pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FES

	Guidance Cues and Growth Cone Motility
	IL-4 Pathway
	Semaphorin Signaling

1 Cell Signaling Technology (CST) Pathway for FES

Tyrosine Kinases / Adaptors

3 GeneGo (Thomson Reuters) Pathways for FES

	Immune response IL-4 signaling pathway
	Neurophysiological process Receptor-mediated axon growth repulsion
	Development EPO-induced Jak-STAT pathway

5/7 BioSystems Pathways for FES (see all 7)

	IL-6 Signaling Pathway
	Kit Receptor Signaling Pathway
	IL-3 Signaling Pathway
	IL-4 signaling Pathway
	Signaling events mediated by VEGFR1 and VEGFR2

5/8 Reactome Pathways for FES (see all 8)

	CRMPs in Sema3A signaling
	Semaphorin interactions
	Developmental Biology
	Signal Transduction
	Signaling by SCF-KIT

1 Kegg Pathway (Kegg details for FES):

Axon guidance

FES for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FES

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for FES (P07332^{2, 3} ENSP00000331504⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EZR	P15311²^,³, ENSP00000338934⁴	MINT-6380367 MINT-6380517 MINT-6380771 MINT-6380343 MINT-8035482 MINT-6380399 MINT-8035497 MINT-6380786 I2D: score=1 STRING: ENSP00000338934
NSF	P46459²^,³, ENSP00000381293⁴	MINT-8217349 I2D: score=2 STRING: ENSP00000381293
ABI1	Q8IZP0²^,³, ENSP00000365312⁴	MINT-7908171 I2D: score=1 STRING: ENSP00000365312
PDE4DIP	Q5VU43²^,³	MINT-8255310 I2D: score=2
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74535 I2D: score=2 STRING: ENSP00000275493

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	TAS	6183005
GO:0007275	multicellular organismal development	TAS	6264598
GO:0007411	axon guidance	TAS	--
GO:0008283	cell proliferation	TAS	6264598
GO:0008360	regulation of cell shape	IMP	18046454

FES for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FES for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for FES

Browse Tocris compounds for FES

2 HMDB Compounds for FES About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

8 Novoseek chemical compound relationships for FES gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	69	90	8955135 (4), 8007965 (4), 7538109 (3), 7523858 (3) (see all 36)
phosphotyrosine	51.3	1	7511210 (1)
phosphatidylinositol	25	3	10405761 (1), 8007965 (1)
retinoic acid	22.7	6	8152313 (2), 8340750 (1), 12642874 (1)
threonine	15.2	1	8955135 (1)
dmso	9.07	2	8340750 (1)
agar	0	1	16455651 (1)
serine	0	1	8955135 (1)

Search CenterWatch for drugs/clinical trials and news about FES

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FES gene (4 alternative transcripts):

NM_001143783.1 NM_001143784.1 NM_001143785.1 NM_002005.3

Unigene Cluster for FES:

Feline sarcoma oncogene

Hs.7636 [show with all ESTs]

Unigene Representative Sequence: BC035357

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000416779 ENST00000328850(uc002bpv.3 uc010uqj.2 uc010uqk.2 uc002bpx.3 uc002bpy.3 uc010bny.3)

ENST00000470152 ENST00000414248 ENST00000481665 ENST00000559355 ENST00000394302

ENST00000452243 ENST00000464684 ENST00000443697 ENST00000394300 ENST00000444422

ENST00000497945 ENST00000494259 ENST00000448367 ENST00000496379 ENST00000462476

ENST00000450438

miRNA Products:		OriGene 3'-UTR Clone (see all 4): FES Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FES
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FES:
		hsa-miR-194* hsa-miR-3916 hsa-miR-3125
		SwitchGear 3'UTR luciferase reporter plasmid: FES 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FES (see all 7) OriGene shRNA RFP: FES OriGene siRNA: FES
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FES

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FES (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FES (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): FES (NM_001143783)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FES

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FES
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FES
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FES

Additional cDNA sequence:

AK300595.1 AK300605.1 AK309530.1 AK312545.1 AY513654.1 AY513655.1 AY513656.1 AY513657.1

BC035357.1 M14209.1 X52192.1

9 DOTS entries:

DT.211690 DT.95370630 DT.121041210 DT.121041225 DT.97839353 DT.100730102 DT.121041214 DT.121041217

DT.121041226

24/85 AceView cDNA sequences (see all 85):

CR593957 BU160929 BQ924403 CK429323 AU105452 BQ712558 BM929822 CR622908

CB850902 BC035357 BX356089 CA389238 BU538316 CR624741 BM684264 NM_002005

CA449888 BU179019 BQ015500 BQ711139 AL540776 BM456755 BX381726 AL703055

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for FES (see all 17) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^
SP1:							-		-						-
SP2:
SP3:															-		-		-		-		-		-		-
SP4:							-		-						-
SP5:							-		-						-												-		-		-		-		-		-				-		-		-		-		-		-

ExUns:	11a	·	11b	^	12a	·	12b	·	12c	·	12d	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b
SP1:					-						-										-
SP2:											-		-		-						-
SP3:
SP4:
SP5:	-				-

ECgene alternative splicing isoforms for FES

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FES expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCAGTGCT

About this image

FES expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FES Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FES

SOURCE GeneReport for Unigene cluster: Hs.7636

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Tissue specificity: Widely expressed. Detected in adult colon epithelium

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FES gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FES¹	feline sarcoma oncogene	74.11(n) 70.24(a)		429374 XM_003641868.1 XP_003641916.1
lizard (Anolis carolinensis)	Reptilia	FES⁶	--	54(a)	1 ↔ 1	GL343759.1(99063-124728)
zebrafish (Danio rerio)	Actinopterygii	Dr.13023²	Transcribed sequence with weak similarity to protein more	77.89(n)		BI882025.1
fruit fly (Drosophila melanogaster)	Insecta	Fps85D³	photoreceptor morphogenesis (sensu Drosophila) more	36(a)		--
worm (Caenorhabditis elegans)	Secernentea	T21G5.1³ ZK622.1¹	tyrosine-protein kinase³ Protein ZK622.1¹	38(a) (best of 33)³ 44.54(n)¹ 38.38(a)¹		I(6882444-6884994)³ 191366¹ NM_062593.1¹ NP_494994.1¹

ENSEMBL Gene Tree for FES (if available)
TreeFam Gene Tree for FES (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FES gene

DSTYK² MATK² FER² CSK²

18/92 SIMAP similar genes for FES using alignment to 10 protein entries: FES_HUMAN (see all proteins) (see all similar genes):

ABL1 BCR/ABL fusion EPHA2 FER EPHA3 EPHA5

EPHA6 PTK2 EPHA4 EPHB2 variant protein EPHB1 EPHB3

FLT3 FLT4 MET BTK kinase deficient isoform 6 FLT1 IGF1R

FES for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6229^1,2	C,F,H,	--	67537246(+)	`CAAGGC/TCGAAG`	2	--	us2k¹		9	MN NS EA WA	800
rs78192020^1,2	C,F,	--	67538192(+)	`AACCAG/CGCCCA`	4	--	us2k¹		3	NA CSA	124
rs79596457^1,2	C,F,	--	67538238(+)	`CTGAGG/CATAGG`	4	--	us2k¹		3	NA CSA	124
rs79865852^1,2	C,F,	--	67538321(+)	`GGGGCG/AGGAGG`	4	--	us2k¹		3	WA NA EA	358
rs59856426^1,2	C,	--	67538404(+)	`GCACTA/TAACTC`	4	--	us2k¹		2	WA	120
rs58147987^1,2	C,	--	67538405(+)	`CACTAA/CACTCC`	4	--	us2k¹		2	WA	120
rs8027907^1,2	C,F,H,	--	67538578(+)	`CTCCAC/TGCCTG`	4	--	us2k¹		10	NS NA WA	1016
rs79856966^1,2	F,	--	67538587(+)	`TGTCCG/ACTCCC`	4	--	us2k¹		1	WA	118
rs8033171^1,2	C,F,A,	--	67538687(+)	`CTGTAT/CCCGAG`	4	--	us2k¹		3	WA	122
rs16944986^1,2	F	--	67538740(+)	`AATGGA/CAGCTG`	4	--	us2k¹		2	MN EA	376

HapMap Linkage Disequilibrium report for FES (91426925 - 91439006 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FES
1 CNV: 49620
Human Gene Mutation Database (HGMD): FES

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FES

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FES for disorders About GeneDecksing

OMIM gene information: 190030 OMIM disorders: --

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Note=Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation of

the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as activated

kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells (PubMed:20111072).

Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid differentiation

(PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or absent in samples

from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses anchorage-independent

growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and might be a predictor of

recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma cells (PubMed:19082481)

18 diseases for FES: About MalaCards

sarcoma acute promyelocytic leukemia hematopoiesis leukemia

myeloid leukemia chronic myeloid leukemia acute myeloid leukemia hemangioma

colorectal cancer hermaphroditism renal carcinoma ovarian carcinoma

lung cancer prostate cancer carcinoma prostatitis

neuronitis lymphoid leukemia

1 disease from the University of Copenhagen DISEASES database for FES:

Sarcoma

10/11 Novoseek disease relationships for FES gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	69.2	10	8634335 (2), 1984516 (2), 10706130 (1), 10567558 (1) (see all 6)
leukaemia lymphocytic	37.9	6	1984516 (2), 1373879 (2), 20030920 (1)
leukemia	31.7	7	1984516 (3), 20030920 (2), 2010659 (1), 16792528 (1)
leukemia promyelocytic acute	27.8	2	8340750 (1), 8152313 (1)
myeloid leukemia chronic	23.7	3	1984516 (1), 15869408 (1)
hemangioma	16.9	1	8792159 (1)
sarcoma	14.9	3	7696187 (1), 17588535 (1)
colorectal cancer	0	2	15867340 (1), 16455651 (1)
tumors	0	15	15867340 (5), 7893977 (2), 2174659 (1), 2394839 (1) (see all 5)
lymphoma	0	2	1373879 (2)

Human Genome Epidemiology (HuGE) Navigator: FES (7 documents)
Tumor Gene Database (TGDB): FES

Export disorders for FES gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FES gene, integrated from 9 sources (see all 136):
(articles sorted by number of sources associating them with FES)

Utopia: connect your pdf to the dynamic
world of online information

A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. (PubMed id 16455651)^{1, 2, 9} Delfino F.J....Smithgall T.E. (2006)
Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells. (PubMed id 19082481)^{1, 2, 9} Kanda S....Smithgall T.E. (2009)
Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. (PubMed id 19001085)^{1, 2, 9} McPherson V.A....Craig A.W. (2009)
The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. (PubMed id 15485904)^{1, 2, 9} Laurent C.E....Smithgall T.E. (2004)
The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase. (PubMed id 16792528)^{1, 2, 9} Delfino F.J....Smithgall T.E. (2006)
Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues. (PubMed id 8955135)^{1, 2, 9} Li J. and Smithgall T.E. (1996)
Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene. (PubMed id 2179816)^{1, 2, 9} Alcalay M.... Pelicci P.G. (1990)
A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells. (PubMed id 11509660)^{1, 2, 9} Cheng H.Y....Smithgall T.E. (2001)
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. (PubMed id 18775312)^{1, 2, 9} Filippakopoulos P....Knapp S. (2008)
Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. (PubMed id 11339827)^{1, 2, 9} Zirngibl R....Greer P.A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2242	HGNC: 3657	AceView: FES	Ensembl:ENSG00000182511	euGenes: HUgn2242
ECgene: FES	Kegg: 2242	H-InvDB: FES

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FES	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FES	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FES gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FES gene:
Search GeneIP for patents involving FES

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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