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FES Gene

protein-coding GIFtS: 69

GC15P089230

feline sarcoma oncogene
(Previous name: feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C-Fes ^³
EC 2.7.10.2 ^³
FPS ^¹, ², ³

Descriptions
Oncogene FES, feline sarcoma virus ^²
c-fes/fps protein ^²
feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog ^¹, ²
feline sarcoma oncogene ^²
proto-oncogene tyrosine-protein kinase Fes/Fps ^²

External Ids
HGNC: 3657¹
Entrez Gene: 2242²
UniProtKB: P07332³
Ensembl: ENSG00000182511⁷

Search outside databases for aliases for FES gene

Previous GC identifers: GC15P087616 GC15P084868 GC15P089014 GC15P089157

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FES:

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with

transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that

activity is required for maintenance of cellular transformation. Its chromosomal location has

linked it to a specific translocation event identified in patients with acute promyelocytic

leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine

receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.

Gene Wiki entry for FES (Feline_sarcoma_oncogene)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FES gene

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25-qter

FES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P089230: (about GC identifiers)

Start:	89,228,703 bp from pter
End:	89,240,010 bp from pter
Size:	11,308 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010274.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FES_HUMAN, P07332 (See protein sequence)

Recommended Name: Proto-oncogene tyrosine-protein kinase Fes/Fps

Size: 822 amino acids; 93497 Da

PDB structures from and Proteopedia :

1WQU (3D)

2DCR (3D)

3BKB (3D)

3CBL (3D)

3CD3 (3D)

Secondary accessions: Q6GTU5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001137255.1 NP_001137256.1 NP_001137257.1 NP_001996.1

ENSEMBL proteins:

ENSP00000331504 ENSP00000377837 ENSP00000377839 ENSP00000377843 ENSP00000377841

Human Recombinant Proteins

	Invitrogen human recombinant proteins for FES
	Millipore Purified and/or Recombinant FES Protein
	Sigma-Aldrich Proteins for FES
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FES)
	Human Recombinant Proteins from Abnova (FES)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348

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Antibodies for FES:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FES
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FES
	Antibodies from Abcam (FES), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FES)
	Novus Biologicals Antibodies for FES

Assays for FES:

	Invitrogen Assays for FES
	Millipore Kits and Assays for the Analysis of FES
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07332

ProtoNet protein and cluster: P07332

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001060 Cdc15/Fes/CIP4

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily

Similarity: Contains 1 FCH domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FES)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FES)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001143783

Applied Biosystems Silencer® siRNAs for FES

Sigma-Aldrich siRNA and siRNA Panels for FES

Sigma-Aldrich shRNA Panels and shRNA for FES

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001143783
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001143783
untagged cDNA clones in CMV expression vector (see all 5): NM_001143783

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002005

UniProtKB/Swiss-Prot: FES_HUMAN, P07332

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for FES:

feline sarcoma viral (v-fes) oncogene;Fujinami avian sarcoma viral (v-fps) oncogene homolog

14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fes):

	craniofacial	digestive/alimentary	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	muscle	nervous system
reproductive system	skin/coat/nails	tumorigenesis	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for FES (Your Favorite Gene powered by Ingenuity)

Semaphorin Signaling in Neurons
Axonal Guidance Signaling

GeneDecks FES for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FES

5/42 Interacting proteins for FES (P07332² ENSP00000331504³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EZR	P15311², ENSP00000356041³	MINT-6380367 MINT-6380399 MINT-6380517 MINT-6380771 MINT-6380786 MINT-6380343 STRING (score=.748)
EGFR	P00533²	MINT-74535
STAT3	ENSP00000264657³	STRING (score=.979)
IRS2	ENSP00000365016³	STRING (score=.975)
BCR	ENSP00000303507³	STRING (score=.974)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	TAS	6264598
GO:0008283	cell proliferation	TAS	6264598
GO:0018108	peptidyl-tyrosine phosphorylation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FES
4 Novoseek chemical compound relationships for FES gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	68.85	88	8955135 (4), 8007965 (4), 7538109 (3), 7523858 (3) (see all 34)
phosphotyrosine	52.33	1	7511210 (1)
phosphatidylinositol	26.61	3	10405761 (1), 8007965 (1)
threonine	16.87	1	8955135 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FES)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FES)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001143783

Sigma-Aldrich siRNA and siRNA Panels for FES

Sigma-Aldrich shRNA Panels and shRNA for FES

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001143783 NM_001143784 NM_001143785 NM_002005

REFSEQ mRNAs for FES gene (4 alternative transcripts):

NM_001143783.1 NM_001143784.1 NM_001143785.1 NM_002005.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001143783 NM_001143784 NM_001143785 NM_002005

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001143783
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001143783
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001143783

Additional cDNA sequence:

AK300595.1 AK300605.1 AK309530.1 AK312545.1 AY513654.1 AY513655.1 AY513656.1 AY513657.1

BC035357.1 CR593957.1 CR622908.1 CR624741.1 M14209.1 X52192.1

9 DOTS entries:

DT.211690 DT.95370630 DT.121041210 DT.121041225 DT.97839353 DT.100730102 DT.121041214 DT.121041217

DT.121041226

24/85 AceView cDNA sequences (see all 85 ):

CB850902 CA449888 CR622908 BM929822 BC035357 CK429323 BQ712558 AU105452

BM684264 CA389238 CR593957 BU179019 BQ924403 BU160929 CR624741 BU538316

BQ015500 NM_002005 BX356089 AI199245 BI910442 BM922880 AL703055 CB990282

highest scoring ESTs for FES:

AA031807 AA813886 AA918653 AA988389 AI081753 AI199245 AI571289 AI862686 AI871941 AI961982

Unigene Cluster for FES:

Feline sarcoma oncogene

Hs.7636 [show with all ESTs]

Unigene Representative Sequence: BC035357

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for FES (see all 17 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^
SP1:							-		-						-
SP2:
SP3:															-		-		-		-		-		-		-
SP4:							-		-						-
SP5:							-		-						-												-		-		-		-		-		-				-		-		-		-		-		-

ExUns:	11a	·	11b	^	12a	·	12b	·	12c	·	12d	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b
SP1:					-						-										-
SP2:											-		-		-						-
SP3:
SP4:
SP5:	-				-

About this scheme

ECgene alternative splicing isoforms for FES

5 Ensembl transcripts including schematic representations:

ENST00000328850 ENST00000394300 ENST00000394302 ENST00000394306 ENST00000394304

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FES expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FES

¹ / ² / ³

3 probe-sets matching FES gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1976_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X06292	0.20	1.00	0.72	1
205418_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002005	0.60	1.00	0.82	1
205418_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FES for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGCAGTGCT

SOURCE GeneReport for Unigene cluster: Hs.7636
Expression variation in blood from EXPOLDB for FES

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FES gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FES¹	--	feline sarcoma oncogene	90.65(n) 94.27(a)	609483 XM_846743.1 XP_851836.1
chimpanzee (Pan troglodytes)	FES¹	--	feline sarcoma oncogene	99.55(n) 99.88(a)	453654 XM_001169425.1 XP_001169425.1
cow (Bos taurus)	FES¹	--	feline sarcoma oncogene	90.27(n) 92.58(a)	507304 NM_001032300.1 NP_001027471.1
rat (Rattus norvegicus)	Fes¹	--	feline sarcoma oncogene	87.1(n) 91.48(a)	361597 XM_341876.3 XP_341877.3
mouse (Mus musculus)	Fes^{1, 5}	7 (39.00 cM)⁵	feline sarcoma oncogene^{1, 5}	87.15(n)¹ 90.63(a)¹	14159¹ NM_010194.2¹ NP_034324.2¹ AF542394⁵ AI586313⁵ (see all 21)

About this table Species with no ortholog for FES

ENSEMBL Gene Tree for FES

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FES gene

FER²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/108 NCBI SNPs in FES are shown (see all 108 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 77)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2856848^1,2	H	89234075(+)	`GCAGGC/GTGACC`	1	L/V	mis¹ ese³		2		EU WA	200
--	rs12906125^1,2	A	89228616(+)	`TCGGGA/GCGGTC`	1	--	ng5¹		0	--	--	--	--
--	rs16944986^1,2	F	89228239(+)	`AATGGA/CAGCTG`	1	--	ng5¹		2		MN EA	376
	rs2227989^1,2	A,C,F,H,O	89237969(+)	`GAAGCC/TGATGG`	1	A/A	syn¹ ese³		8		MN NA EU EA WA	638
	rs2229074^1,2	A,C,F,O	89235281(+)	`TACCAC/TGGGGC`	1	H/H	syn¹ ese³		4		MN NA	170
	rs11539637^1,2	C,F,H	89229294(+)	`TCTTCT/CGAGCT`	1	S/S	syn¹		4		EU EA WA	412
	rs2071383^1,2	C,F	89231440(+)	`AAGGCC/TAAGGA`	1	A/A	syn¹		11		EA MN NA CSAM	2180
	rs2856846^1,2	H	89233781(+)	`GTCACG/ATTCGA`	1	T/T	syn¹ ese³		4		EU EA WA	410
	rs1894400^1,2	A,C,F,H	89229959(+)	`TGATGC/TAGCTT`	1	--	int¹		3		EU EA	300
	rs11638635^1,2	A,C,F,H	89236520(+)	`CCTACC/GCTGAA`	1	--	int¹		7		NA EU EA WA	556

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HapMap Linkage Disequilibrium images for FES (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 190030

10/11 Novoseek disease relationships for FES gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	68.07	9	8634335 (2), 1984516 (2), 10706130 (1), 10567558 (1) (see all 5)
leukemia	29.76	5	1984516 (3), 2010659 (1), 16792528 (1)
leukemia promyelocytic acute	29.40	2	8340750 (1), 8152313 (1)
leukaemia lymphocytic	27.72	5	1984516 (2), 1373879 (2)
myeloid leukemia chronic	25.54	3	1984516 (1), 15869408 (1)
hemangioma	18.68	1	8792159 (1)
sarcoma	16.85	3	7696187 (1), 17588535 (1)
cancer	0.00	1	15867340 (1)
tumors	0.00	15	15867340 (5), 7893977 (2), 2174659 (1), 2394839 (1) (see all 5)
lymphoma	0.00	2	1373879 (2)

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Human Gene Mutation Database: FES
Tumor Gene Database: FES

(Possibly Related Articles in Doctor's Guide)
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RSNA MEETING: Imaging Reveals If Breast Cancer Treatment Is Working

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/109 PubMed articles for FES gene (see all 109 ):

Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene. (PubMed id 2179816)^{1, 3, 4} Alcalay M.... Pelicci P.G. (1990)
Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. (PubMed id 15929003)^{3, 4} Scott A....Guentert P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
An insertion deletion polymorphism associated with C-FES. (PubMed id 1870997)^{2, 3} Bowden D.W....Rothschild C.B. (1991)
The structure of the human c-fes/fps proto-oncogene. (PubMed id 4065096)^{3, 4} Roebroek A.J.M.... van de Ven W.J.M. (1985)
The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl. (PubMed id 10706130)^{1, 3} Lionberger J.M. and Smithgall T.E. (2000)
Expression of truncated transcripts of the proto-oncogene c-fps/fes in human lymphoma and lymphoid leukemia cell lines. (PubMed id 1373879)^{1, 3} Jucker M....Tesch H. (1992)
Functional specificity of cytoplasmic and transmembrane tyrosine kinases: identification of 130- and 75-kilodalton substrates of c-fps/fes tyrosine kinase in macrophages. (PubMed id 8007965)^{1, 3} Areces L.B....Feldman R.A. (1994)
A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. (PubMed id 16455651)^{1, 3} Delfino F.J....Smithgall T.E. (2006)
Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues. (PubMed id 8663427)^{1, 3} Rogers J.A....Smithgall T.E. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2242	HGNC: 3657	AceView: FES	Ensembl:ENSG00000182511	euGenes: HUgn2242
ECgene: FES	H-InvDB: FES

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FES	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FES
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FES:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FES-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FES		Antibodies for FES
	Explore super-pooled esiRNAs		Proteins for FES
	Lentivirus-delivered shRNAs for FES		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FES)
	Antibodies (FES)
	Chimera RNAi (FES)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FES

	Recombinant Proteins (FES)
	Antibodies (FES)

Search OriGene for FES

Search Tocris compounds for FES

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Antibodies for FES

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FES Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for FES

Summaries
for FES

Genomic Location
for FES

Proteins
for FES

Protein Domains/
Families
for FES

Gene Function
for FES

Pathways & Interactions
for FES

Drugs & Compounds
for FES

Transcripts
for FES

Expression
for FES

Orthologs
for FES

Paralogs
for FES

SNPs/Variants
for FES

Disorders & Mutations
for FES

Medical News
for FES

Publications
for FES

Search for FES

Genome Databases showing FES

Other Databases showing FES

Specialized Databases showing FES

Licensable Technologies
for FES

Services
for FES

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FES Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor FES

Summariesfor FES

Genomic Locationfor FES

Proteinsfor FES

Protein Domains/Familiesfor FES

Gene Functionfor FES

Pathways & Interactionsfor FES

Drugs & Compoundsfor FES

Transcriptsfor FES

Expression for FES

Orthologsfor FES

Paralogsfor FES

SNPs/Variantsfor FES

Disorders & Mutationsfor FES

Medical Newsfor FES

Publicationsfor FES

Search for FES

Genome Databases showing FES

Other Databases showing FES

Specialized Databases showing FES

Licensable Technologiesfor FES

Servicesfor FES

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FES

Summaries
for FES

Genomic Location
for FES

Proteins
for FES

Protein Domains/
Families
for FES

Gene Function
for FES

Pathways & Interactions
for FES

Drugs & Compounds
for FES

Transcripts
for FES

Expression
for FES

Orthologs
for FES

Paralogs
for FES

SNPs/Variants
for FES

Disorders & Mutations
for FES

Medical News
for FES

Publications
for FES

Licensable Technologies
for FES

Services
for FES