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Aliases for FES Gene

Aliases for FES Gene

  • FES Proto-Oncogene, Tyrosine Kinase 2 3
  • Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog 2 3
  • Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog 3 4
  • Feline Sarcoma Oncogene 2 3
  • Proto-Oncogene C-Fes 3 4
  • Proto-Oncogene C-Fps 3 4
  • EC 2.7.10.2 4 63
  • P93c-Fes 3 4
  • FPS 3 4
  • Proto-Oncogene Tyrosine-Protein Kinase Fes/Fps 3
  • Oncogene FES, Feline Sarcoma Virus 3
  • Tyrosine-Protein Kinase Fes/Fps 3
  • Feline Sarcoma Virus 2
  • C-Fes/Fps Protein 2
  • Oncogene FES 2
  • EC 2.7.10 63

External Ids for FES Gene

Previous GeneCards Identifiers for FES Gene

  • GC15P087616
  • GC15P084868
  • GC15P089014
  • GC15P089157
  • GC15P089230
  • GC15P091426
  • GC15P067539

Summaries for FES Gene

Entrez Gene Summary for FES Gene

  • This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for FES Gene

FES (FES Proto-Oncogene, Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FES include sarcoma. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include protein tyrosine kinase activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for FES Gene

  • Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.

Gene Wiki entry for FES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FES Gene

Genomics for FES Gene

Regulatory Elements for FES Gene

Transcription factor binding sites by QIAGEN in the FES gene promoter:

Genomic Location for FES Gene

Start:
90,883,695 bp from pter
End:
90,895,776 bp from pter
Size:
12,082 bases
Orientation:
Plus strand

Genomic View for FES Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FES Gene

Proteins for FES Gene

  • Protein details for FES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07332-FES_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fes/Fps
    Protein Accession:
    P07332
    Secondary Accessions:
    • B2R6E6
    • B4DUD0
    • E9PC94
    • E9PC95
    • Q2VXS7
    • Q2VXS8
    • Q2VXT0
    • Q6GTU5

    Protein attributes for FES Gene

    Size:
    822 amino acids
    Molecular mass:
    93497 Da
    Quaternary structure:
    • Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules.
    Miscellaneous:
    • Cellular homolog of retroviral oncogenes. In contrast to the viral oncoproteins, the kinase activity of cellular FSP/FES is tightly regulated, and the kinase is inactive in normal cells in the absence of activating stimuli (PubMed:15485904).

    Three dimensional structures from OCA and Proteopedia for FES Gene

    Alternative splice isoforms for FES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FES Gene

Proteomics data for FES Gene at MOPED

Post-translational modifications for FES Gene

  • Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
  • Ubiquitination at Lys725
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FES (Fes)

Domains for FES Gene

Gene Families for FES Gene

HGNC:
  • SH2D :SH2 domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for FES Gene

Graphical View of Domain Structure for InterPro Entry

P07332

UniProtKB/Swiss-Prot:

FES_HUMAN :
  • P07332
Domain:
  • The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization and probably also interaction with other proteins
  • The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes
  • Contains 1 F-BAR domain.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
genes like me logo Genes that share domains with FES: view

Function for FES Gene

Molecular function for FES Gene

GENATLAS Biochemistry: feline sarcoma viral (v-fes) oncogene;Fujinami avian sarcoma viral (v-fps) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Kinase activity is tightly regulated. Activated in response to signaling from a cell surface receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713. Present in an inactive form in the absence of activating stimuli.
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.

Enzyme Numbers (IUBMB) for FES Gene

Gene Ontology (GO) - Molecular Function for FES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IDA 11509660
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA 15485904
GO:0005515 protein binding IPI 18046454
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FES: view
genes like me logo Genes that share phenotypes with FES: view

Animal Models for FES Gene

MGI Knock Outs for FES:

Animal Model Products

CRISPR Products

miRNA for FES Gene

miRTarBase miRNAs that target FES

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FES

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for FES Gene

Localization for FES Gene

Subcellular locations from UniProtKB/Swiss-Prot for FES Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FES Gene COMPARTMENTS Subcellular localization image for FES gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
plasma membrane 5
nucleus 3
chloroplast 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11339827
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
GO:0005925 focal adhesion IDA 18046454
genes like me logo Genes that share ontologies with FES: view

Pathways for FES Gene

genes like me logo Genes that share pathways with FES: view

Gene Ontology (GO) - Biological Process for FES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 6183005
GO:0006935 chemotaxis IBA --
GO:0007173 epidermal growth factor receptor signaling pathway IBA --
GO:0007275 multicellular organismal development TAS 6264598
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with FES: view

Compounds for FES Gene

(2) HMDB Compounds for FES Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(8) Novoseek inferred chemical compound relationships for FES Gene

Compound -log(P) Hits PubMed IDs
tyrosine 69 63
phosphotyrosine 51.3 1
phosphatidylinositol 25 2
retinoic acid 22.7 4
threonine 15.2 1
genes like me logo Genes that share compounds with FES: view

Transcripts for FES Gene

Unigene Clusters for FES Gene

Feline sarcoma oncogene:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FES

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FES Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - - - - - - - - - - -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - -
SP12: - -
SP13: -
SP14:
SP15: -
SP16: - -
SP17:

ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for FES Gene

GeneLoc Exon Structure for
FES
ECgene alternative splicing isoforms for
FES

Expression for FES Gene

mRNA expression in normal human tissues for FES Gene

mRNA differential expression in normal tissues according to GTEx for FES Gene

This gene is overexpressed in Whole Blood (14.3) and Spleen (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FES Gene

SOURCE GeneReport for Unigene cluster for FES Gene Hs.7636

mRNA Expression by UniProt/SwissProt for FES Gene

P07332-FES_HUMAN
Tissue specificity: Widely expressed. Detected in adult colon epithelium.
genes like me logo Genes that share expressions with FES: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FES Gene

Orthologs for FES Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FES 35
  • 99.47 (n)
  • 99.88 (a)
FES 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FES 35
  • 90.23 (n)
  • 92.58 (a)
FES 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FES 35
  • 90.61 (n)
  • 94.27 (a)
FES 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fes 35
  • 87.1 (n)
  • 90.63 (a)
Fes 16
Fes 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FES 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FES 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fes 35
  • 87.06 (n)
  • 91.48 (a)
chicken
(Gallus gallus)
Aves FES 35
  • 74.11 (n)
  • 70.24 (a)
FES 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FES 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489191 35
  • 63.98 (n)
  • 65.77 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13023 35
fes 35
  • 61.33 (n)
  • 58.13 (a)
fes 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fps85D 36
  • 24 (a)
OneToMany
Fps85D 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea R11E3.1 36
  • 24 (a)
ManyToMany
ZK622.1 35
  • 44.63 (n)
  • 38.38 (a)
F59A3.8 37
  • 27 (a)
F23C8.7 37
  • 34 (a)
ZK593.9 37
  • 28 (a)
T25B9.5 37
  • 31 (a)
C25A8.5 37
  • 34 (a)
Y116A8C.38 37
  • 28 (a)
F26E4.5 37
  • 36 (a)
kin-24 37
  • 27 (a)
C35E7.10b 37
  • 34 (a)
W02A2.4 37
  • 34 (a)
frk-1 37
  • 36 (a)
ZC581.7 37
  • 34 (a)
spe-8 37
  • 33 (a)
T21G5.1 37
  • 38 (a)
T25B9.4 37
  • 29 (a)
kin-14 37
  • 36 (a)
T06C10.3 37
  • 30 (a)
Y52D5A.2 37
  • 32 (a)
R05H5.4 37
  • 33 (a)
F57B9.8 37
  • 32 (a)
K09B11.5 37
  • 29 (a)
F01D4.3 37
  • 33 (a)
C18H7.4 37
  • 33 (a)
R11E3.1 37
  • 30 (a)
C55C3.4 37
  • 34 (a)
kin-26 37
  • 32 (a)
W04G5.10 37
  • 37 (a)
Y69E1A.3 37
  • 30 (a)
W03F8.2 37
  • 27 (a)
C35E7.10a 37
  • 33 (a)
ZK622.1 37
  • 36 (a)
F46F5.2 37
  • 31 (a)
Y116A8C.24 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for FES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FES Gene

ENSEMBL:
Gene Tree for FES (if available)
TreeFam:
Gene Tree for FES (if available)

Paralogs for FES Gene

Paralogs for FES Gene

genes like me logo Genes that share paralogs with FES: view

Variants for FES Gene

Sequence variations from dbSNP and Humsavar for FES Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs916113 -- 90,890,828(+) GTCCA(A/G)TGCCC intron-variant
rs1894400 -- 90,885,725(+) TGATG(C/T)AGCTT intron-variant
rs1894401 -- 90,885,812(+) TGGGA(A/G)TGTAA intron-variant
rs2071382 -- 90,884,967(+) CCCAG(C/T)CTCCT upstream-variant-2KB, intron-variant
rs2071383 -- 90,887,206(+) AAGGC(C/G/T)AAGGA synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FES Gene

Variant ID Type Subtype PubMed ID
nsv833089 CNV Loss 17160897
nsv515661 CNV Loss 19592680
dgv2436n71 CNV Loss 21882294

Relevant External Links for FES Gene

HapMap Linkage Disequilibrium report
FES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FES Gene

Disorders for FES Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FES Gene including...

Search for FES Gene in MalaCards »

UniProtKB/Swiss-Prot

FES_HUMAN
  • Note=Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation of the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as activated kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells (PubMed:20111072). Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid differentiation (PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or absent in samples from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses anchorage-independent growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and might be a predictor of recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma cells (PubMed:19082481). {ECO:0000269 PubMed:16455651, ECO:0000269 PubMed:19082481, ECO:0000269 PubMed:20111072, ECO:0000269 PubMed:21563194, ECO:0000269 PubMed:2656706}.

(1) University of Copenhagen DISEASES for FES Gene

(11) Novoseek inferred disease relationships for FES Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 69.2 8
leukaemia lymphocytic 37.9 5
leukemia 31.7 7
leukemia promyelocytic acute 27.8 2
myeloid leukemia chronic 23.7 2

Relevant External Links for FES

Genetic Association Database (GAD)
FES
Human Genome Epidemiology (HuGE) Navigator
FES
Tumor Gene Database (TGDB):
FES
genes like me logo Genes that share disorders with FES: view

Publications for FES Gene

  1. Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene. (PMID: 2179816) Alcalay M. … Pelicci P.G. (Oncogene 1990) 3 4 23
  2. Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues. (PMID: 8955135) Li J. … Smithgall T.E. (J. Biol. Chem. 1996) 3 4 23
  3. Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. (PMID: 11339827) Zirngibl R. … Greer P.A. (Exp. Cell Res. 2001) 3 4 23
  4. A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells. (PMID: 11509660) Cheng H.Y. … Smithgall T.E. (Mol. Cell. Biol. 2001) 3 4 23
  5. The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. (PMID: 15485904) Laurent C.E. … Smithgall T.E. (Mol. Cell. Biol. 2004) 3 4 23

Products for FES Gene

  • Addgene plasmids for FES

Sources for FES Gene

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