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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FES Gene

protein-coding   GIFtS: 72
GCID: GC15P091426

Feline Sarcoma Oncogene

(Previous name: feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Feline Sarcoma Oncogene1 2     C-Fes/Fps Protein1
Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma
(PRCII) Viral (V-Fps) Oncogene Homolog1 2
     Feline Sarcoma Virus1
Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog2 3     Oncogene FES1
Proto-Oncogene C-Fes2 3     Oncogene FES, Feline Sarcoma Virus2
Proto-Oncogene C-Fps2 3     Proto-Oncogene Tyrosine-Protein Kinase Fes/Fps2
FPS2 3     Tyrosine-Protein Kinase Fes/Fps2
p93c-fes2 3     EC 2.7.108
EC 2.7.10.23 8     

External Ids:    HGNC: 36571   Entrez Gene: 22422   Ensembl: ENSG000001825117   OMIM: 1900305   UniProtKB: P073323   

Export aliases for FES gene to outside databases

Previous GC identifers: GC15P087616 GC15P084868 GC15P089014 GC15P089157 GC15P089230 GC15P067539


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FES Gene:
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming
capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for
maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event
identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well
as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding
different isoforms.(provided by RefSeq, Jan 2009)

GeneCards Summary for FES Gene: 
FES (feline sarcoma oncogene) is a protein-coding gene. Diseases associated with FES include sarcoma, and acute promyelocytic leukemia, and among its related super-pathways are SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion and Axon guidance. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is DSTYK.

UniProtKB/Swiss-Prot: FES_HUMAN, P07332
Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the
regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in
FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the
activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of
mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in
response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced
activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1,
STAT3 and TRIM28

Gene Wiki entry for FES (Feline sarcoma oncogene) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FES gene promoter:
         AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FES promoter sequence
   Search SABiosciences Chromatin IP Primers for FES

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

FES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FES gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091426:  view genomic region     (about GC identifiers)

Start:
91,426,925 bp from pter      End:
91,439,006 bp from pter
Size:
12,082 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FES_HUMAN, P07332 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fes/Fps  
Size: 822 amino acids; 93497 Da
Subunit: Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28.
Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated
KIT. Interacts with FLT3. Interacts (via FCH domain) with soluble tubulin. Interacts (via SH2 domain) with
microtubules
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein;
Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed
throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the
kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the
lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular
membrane structures in the cytoplasm and at the cell periphery
Miscellaneous: Cellular homolog of retroviral oncogenes. In contrast to the viral oncoproteins, the kinase
activity of cellular FSP/FES is tightly regulated, and the kinase is inactive in normal cells in the absence of
activating stimuli (PubMed:15485904)
6/7 PDB 3D structures from and Proteopedia for FES (see all 7):
1WQU (3D)        2DCR (3D)        3BKB (3D)        3CBL (3D)        3CD3 (3D)        4DYL (3D)    
Secondary accessions: B2R6E6 B4DUD0 E9PC94 E9PC95 Q2VXS7 Q2VXS8 Q2VXT0 Q6GTU5
Alternative splicing: 4 isoforms:  P07332-1   P07332-2   P07332-3   P07332-4   

Explore the universe of human proteins at neXtProt for FES: NX_P07332

Explore proteomics data for FES at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07332

  • 4/22 DME Specific Peptides for FES (P07332) (see all 22)
     RDLAARN  KWTAPEA  KAKFLQEA  TKKSGVVL 

    FES Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FES Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001137255.1  NP_001137256.1  NP_001137257.1  NP_001996.1  

    ENSEMBL proteins: 
     ENSP00000410477   ENSP00000331504   ENSP00000454146   ENSP00000414629   ENSP00000454089  
     ENSP00000377839   ENSP00000392696   ENSP00000435811   ENSP00000395425   ENSP00000377837  
     ENSP00000400868   ENSP00000409915  
    Reactome Protein details: P07332
    Human Recombinant Protein Products for FES: 
    EMD Millipore Purified and/or Recombinant FES Protein
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    Sino Biological Cell Lysate for FES 
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    Cloud-Clone Corp. Proteins for FES 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11339827
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion IDA18046454
    GO:0015630microtubule cytoskeleton IDA15485904

    FES for ontologies           About GeneDecksing



    FES Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: feline sarcoma oncogene 
    Fer family

    5/9 InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001060 FCH_dom
     IPR011009 Kinase-like_dom
     IPR016250 Tyr_kinase_non-rcpt_Fes_subgr
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P07332

    ProtoNet protein and cluster: P07332

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001060 Cdc15/Fes/CIP4
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FES_HUMAN, P07332
    Domain: The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization
    and probably also interaction with other proteins
    Domain: The N-terminal region including the first coiled coil domain mediates interaction with
    phosphoinositide-containing membranes
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain


    FES for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FES_HUMAN, P07332
    Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the
    regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in
    FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the
    activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of
    mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in
    response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced
    activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1,
    STAT3 and TRIM28
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Kinase activity is tightly regulated. Activated in response to signaling from a cell surface
    receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at
    Tyr-713. Present in an inactive form in the absence of activating stimuli

         Genatlas biochemistry entry for FES:
    feline sarcoma viral (v-fes) oncogene;Fujinami avian sarcoma viral (v-fps) oncogene homolog

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA11509660
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA15485904
    GO:0005515protein binding IPI18046454
    GO:0005524ATP binding IEA--
         
    FES for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FES:
     Decreased substrate adherent c  Decreased telomerase activity  Increased cell death HMECs cel  Weaker migration 

         15/17 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fes) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  normal  reproductive system 

    FES for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FES: Festm2Mcs Festm2Pag Festm1Mcs

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FES 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FES 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FES 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FES
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FES:
    hsa-miR-194* hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidFES 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FES


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FES About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.45
    CRMPs in Sema3A signaling0.36
    Sema3A PAK dependent Axon repulsion0.45
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion0.94
    4PIP3 activates AKT signaling
    Signaling by SCF-KIT0.72
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for FES
        Neurophysiological process Receptor-mediated axon growth repulsion
    Development EPO-induced Jak-STAT pathway
    Immune response IL-4 signaling pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FES
        Guidance Cues and Growth Cone Motility
    IL-4 Pathway
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for FES
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for FES
        Immune response IL-4 signaling pathway
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development EPO-induced Jak-STAT pathway

    5/7 BioSystems Pathways for FES (see all 7)
        IL-4 signaling Pathway
    Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    IL-3 Signaling Pathway
    Angiopoietin receptor Tie2-mediated signaling


    5/8        Reactome Pathways for FES (see all 8)
        CRMPs in Sema3A signaling
    Semaphorin interactions
    Developmental Biology
    Signal Transduction
    Signaling by SCF-KIT


    1         Kegg Pathway  (Kegg details for FES):
        Axon guidance


    FES for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for FES (P073322, 3 ENSP000003315044) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153112, 3, ENSP000003389344MINT-6380367 MINT-6380517 MINT-6380771 MINT-6380343 MINT-8035482 MINT-6380399 MINT-8035497 MINT-6380786 I2D: score=1 STRING: ENSP00000338934
    NSFP464592, 3, ENSP000003812934MINT-8217349 I2D: score=2 STRING: ENSP00000381293
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908171 I2D: score=1 STRING: ENSP00000365312
    PDE4DIPQ5VU432, 3MINT-8255310 I2D: score=2 
    EGFRP005332, 3, ENSP000002754934MINT-74535 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS6183005
    GO:0007275multicellular organismal development TAS6264598
    GO:0007411axon guidance TAS--
    GO:0008283cell proliferation TAS6264598
    GO:0008360regulation of cell shape IMP11509660

    FES for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FES for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for FES

    Browse Tocris compounds for FES

    2 HMDB Compounds for FES    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for FES gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 69 90 8955135 (4), 8007965 (4), 7538109 (3), 7523858 (3) (see all 36)
    phosphotyrosine 51.3 1 7511210 (1)
    phosphatidylinositol 25 3 10405761 (1), 8007965 (1)
    retinoic acid 22.7 6 8152313 (2), 8340750 (1), 12642874 (1)
    threonine 15.2 1 8955135 (1)
    dmso 9.07 2 8340750 (1)
    agar 0 1 16455651 (1)
    serine 0 1 8955135 (1)

    Search CenterWatch for drugs/clinical trials and news about FES

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FES gene (4 alternative transcripts): 
    NM_001143783.1  NM_001143784.1  NM_001143785.1  NM_002005.3  

    Unigene Cluster for FES:

    Feline sarcoma oncogene
    Hs.7636  [show with all ESTs]
    Unigene Representative Sequence: BC035357
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416779 ENST00000328850(uc002bpv.3 uc010uqj.2 uc010uqk.2 uc002bpx.3 uc002bpy.3 uc010bny.3)
    ENST00000470152 ENST00000414248 ENST00000481665 ENST00000559355 ENST00000394302
    ENST00000452243 ENST00000464684 ENST00000443697 ENST00000394300 ENST00000444422
    ENST00000497945 ENST00000494259 ENST00000448367 ENST00000496379 ENST00000462476
    ENST00000450438
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK300595.1 AK300605.1 AK309530.1 AK312545.1 AY513654.1 AY513655.1 AY513656.1 AY513657.1 
    BC035357.1 M14209.1 X52192.1 

    9 DOTS entries:

    DT.211690  DT.95370630  DT.121041210  DT.121041225  DT.97839353  DT.100730102  DT.121041214  DT.121041217 
    DT.121041226 

    24/85 AceView cDNA sequences (see all 85):

    BU179019 CK429323 BM929822 BQ924403 BC035357 NM_002005 BU160929 CA389238 
    CA449888 AU105452 BQ712558 CB850902 CR622908 BM684264 CR624741 CR593957 
    BQ015500 BX356089 BU538316 AL703055 BU184736 BX327963 BM769633 BI910442 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for FES (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^
    SP1:                    -     -                 -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                            -     -     -     -     -     -     -                                                                           
    SP4:                    -     -                 -                                                                                                               
    SP5:                    -     -                 -                                   -     -     -     -     -     -           -     -     -     -     -     -   

    ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
    SP1:              -                 -                             -                                             
    SP2:                                -     -     -                 -                                             
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:  -           -                                                                                             


    ECgene alternative splicing isoforms for FES

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FES expression in normal human tissues (normalized intensities)      FES embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGTGCT
    FES Expression
    About this image


    FES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             cd14+ cells   

    See FES Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FES

    SOURCE GeneReport for Unigene cluster: Hs.7636

    UniProtKB/Swiss-Prot: FES_HUMAN, P07332
    Tissue specificity: Widely expressed. Detected in adult colon epithelium

        SABiosciences Custom PCR Arrays for FES
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FES gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fes1 , 5 feline sarcoma oncogene1, 5 87.1(n)1
    90.63(a)1
      7 (45.65 cM)5
    141591  NM_010194.21  NP_034324.21 
     803777585 
    chicken
    (Gallus gallus)
    Aves FES1 feline sarcoma oncogene 74.11(n)
    70.24(a)
      429374  XM_003641868.1  XP_003641916.1 
    lizard
    (Anolis carolinensis)
    Reptilia FES6
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343759.1(99059-124728)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130232 Transcribed sequence with weak similarity to protein more 77.89(n)    BI882025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fps85D3 photoreceptor morphogenesis (sensu
    Drosophila) more
    36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T21G5.13
    ZK622.11
    tyrosine-protein kinase3
    Protein ZK622.11
    38(a)
    (best of 33)3
    44.54(n)1
    38.38(a)1
      I(6882444-6884994)3
    1913661  NM_062593.11  NP_494994.11 


    ENSEMBL Gene Tree for FES (if available)
    TreeFam Gene Tree for FES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FES gene
    DSTYK2  MATK2  FER2  CSK2  
    18/112 SIMAP similar genes for FES using alignment to 10 protein entries:     FES_HUMAN (see all proteins) (see all similar genes):
    ABL1    BCR/ABL fusion    EPHA2    FER    EPHA3    EPHA5
    EPHA6    PTK2    EPHA4    EPHB2 variant protein    EPHB1    EPHB3
    FLT3    FLT4    MET    BTK kinase deficient isoform 6    FLT1    IGF1R

    FES for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/493 SNPs in FES are shown (see all 493)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999420961,2
    C--67545463(+) AGCGGG/TTNNNN 4 -- int10--------
    rs342980471,2
    C,F--67549486(+) TGACA-/AGAGAG 4 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs62291,2
    C,F,H--71150123(+) CAAGGC/TCGAAG 2 -- us2k19Minor allele frequency- T:0.09MN NS EA WA 800
    rs1917007241,2
    --71150695(+) AGGTGA/GTGGCA 4 -- us2k10--------
    rs47021,2
    C,F,A,H--71150942(+) AAGATA/GCTGGG 4 -- us2k130Minor allele frequency- G:0.39MN EA NS NA WA CSA 4392
    rs1436699431,2
    C--71151008(+) TATTTA/GATGGA 4 -- us2k10--------
    rs781920201,2
    C,F--71151069(+) AACCAG/CGCCCA 4 -- us2k13Minor allele frequency- C:0.13NA CSA 124
    rs1113166971,2
    C--71151070(+) ACCAGA/GCCCAG 4 -- us2k10--------
    rs1132727431,2
    C--71151071(+) CCAGGA/CCCAGT 4 -- us2k10--------
    rs795964571,2
    C,F--71151115(+) CTGAGG/CATAGG 4 -- us2k13Minor allele frequency- C:0.13NA CSA 124

    HapMap Linkage Disequilibrium report for FES (91426925 - 91439006 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FES:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    nsv515661CNV Loss19592680
    dgv2436n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190030    OMIM disorders: --

    UniProtKB/Swiss-Prot: FES_HUMAN, P07332
  • Note=Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation
    of the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as
    activated kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells
    (PubMed:20111072). Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid
    differentiation (PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or
    absent in samples from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses
    anchorage-independent growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and
    might be a predictor of recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma
    cells (PubMed:19082481)

  • 14 diseases for FES:    About MalaCards
    sarcoma    acute promyelocytic leukemia    myeloid leukemia    hemangioma
    chronic myeloid leukemia    leukemia    acute myeloid leukemia    colorectal cancer
    endotheliitis    lung cancer    prostate cancer    colon cancer
    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FES:
    Sarcoma

    FES for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for FES gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 69.2 10 8634335 (2), 1984516 (2), 10706130 (1), 10567558 (1) (see all 6)
    leukaemia lymphocytic 37.9 6 1984516 (2), 1373879 (2), 20030920 (1)
    leukemia 31.7 7 1984516 (3), 20030920 (2), 2010659 (1), 16792528 (1)
    leukemia promyelocytic acute 27.8 2 8340750 (1), 8152313 (1)
    myeloid leukemia chronic 23.7 3 1984516 (1), 15869408 (1)
    hemangioma 16.9 1 8792159 (1)
    sarcoma 14.9 3 7696187 (1), 17588535 (1)
    colorectal cancer 0 2 15867340 (1), 16455651 (1)
    tumors 0 15 15867340 (5), 7893977 (2), 2174659 (1), 2394839 (1) (see all 5)
    lymphoma 0 2 1373879 (2)

    Genetic Association Database (GAD): FES
    Human Genome Epidemiology (HuGE) Navigator: FES (7 documents)
    Tumor Gene Database (TGDB): FES

    Export disorders for FES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FES gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with FES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. (PubMed id 16455651)1, 2, 9 Delfino F.J....Smithgall T.E. (2006)
    2. Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells. (PubMed id 19082481)1, 2, 9 Kanda S....Smithgall T.E. (2009)
    3. Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. (PubMed id 19001085)1, 2, 9 McPherson V.A....Craig A.W. (2009)
    4. The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. (PubMed id 15485904)1, 2, 9 Laurent C.E....Smithgall T.E. (2004)
    5. The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase. (PubMed id 16792528)1, 2, 9 Delfino F.J....Smithgall T.E. (2006)
    6. Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues. (PubMed id 8955135)1, 2, 9 Li J. and Smithgall T.E. (1996)
    7. Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene. (PubMed id 2179816)1, 2, 9 Alcalay M.... Pelicci P.G. (1990)
    8. A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells. (PubMed id 11509660)1, 2, 9 Cheng H.Y....Smithgall T.E. (2001)
    9. Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. (PubMed id 18775312)1, 2, 9 Filippakopoulos P....Knapp S. (2008)
    10. Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. (PubMed id 11339827)1, 2, 9 Zirngibl R....Greer P.A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2242 HGNC: 3657 AceView: FES Ensembl:ENSG00000182511 euGenes: HUgn2242
    ECgene: FES Kegg: 2242 H-InvDB: FES

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FES Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FES Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FES gene:
    Search GeneIP for patents involving FES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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