Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FES Gene

protein-coding   GIFtS: 74
GCID: GC15P091426

Feline Sarcoma Oncogene

(Previous name: feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian...)
  See FES-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Feline Sarcoma Oncogene1 2     C-Fes/Fps Protein1
Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma
(PRCII) Viral (V-Fps) Oncogene Homolog1 2
     Feline Sarcoma Virus1
Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog2 3     Oncogene FES1
Proto-Oncogene C-Fes2 3     Oncogene FES, Feline Sarcoma Virus2
Proto-Oncogene C-Fps2 3     Proto-Oncogene Tyrosine-Protein Kinase Fes/Fps2
FPS2 3     Tyrosine-Protein Kinase Fes/Fps2
p93c-fes2 3     EC 2.7.108
EC 2.7.10.23 8     

External Ids:    HGNC: 36571   Entrez Gene: 22422   Ensembl: ENSG000001825117   OMIM: 1900305   UniProtKB: P073323   

Export aliases for FES gene to outside databases

Previous GC identifers: GC15P087616 GC15P084868 GC15P089014 GC15P089157 GC15P089230 GC15P067539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FES Gene:
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming
capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for
maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event
identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well
as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding
different isoforms.(provided by RefSeq, Jan 2009)

GeneCards Summary for FES Gene:
FES (feline sarcoma oncogene) is a protein-coding gene. Diseases associated with FES include sarcoma, and acute promyelocytic leukemia. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: FES_HUMAN, P07332
Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the
regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in
FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the
activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of
mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in
response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced
activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1,
STAT3 and TRIM28

Gene Wiki entry for FES (Feline sarcoma oncogene) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FES gene promoter:
         AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FES promoter sequence
   Search Chromatin IP Primers for FES

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

FES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FES gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091426:  view genomic region     (about GC identifiers)

Start:
91,426,925 bp from pter      End:
91,439,006 bp from pter
Size:
12,082 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FES_HUMAN, P07332 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fes/Fps  
Size: 822 amino acids; 93497 Da
Subunit: Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28.
Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated
KIT. Interacts with FLT3. Interacts (via FCH domain) with soluble tubulin. Interacts (via SH2 domain) with
microtubules
Miscellaneous: Cellular homolog of retroviral oncogenes. In contrast to the viral oncoproteins, the kinase
activity of cellular FSP/FES is tightly regulated, and the kinase is inactive in normal cells in the absence of
activating stimuli (PubMed:15485904)
Selected PDB 3D structures from and Proteopedia for FES (see all 7):
1WQU (3D)        2DCR (3D)        3BKB (3D)        3CBL (3D)        3CD3 (3D)        4DYL (3D)    
Secondary accessions: B2R6E6 B4DUD0 E9PC94 E9PC95 Q2VXS7 Q2VXS8 Q2VXT0 Q6GTU5
Alternative splicing: 4 isoforms:  P07332-1   P07332-2   P07332-3   P07332-4   

Explore the universe of human proteins at neXtProt for FES: NX_P07332

Explore proteomics data for FES at MOPED

Post-translational modifications: 

  • Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK1
  • Ubiquitination2 at Lys725
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FES (P07332) (see all 22)
     RDLAARN  KWTAPEA  KAKFLQEA  TKKSGVVL 


    See FES Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137255.1  NP_001137256.1  NP_001137257.1  NP_001996.1  

    ENSEMBL proteins: 
     ENSP00000410477   ENSP00000331504   ENSP00000454146   ENSP00000414629   ENSP00000454089  
     ENSP00000377839   ENSP00000392696   ENSP00000435811   ENSP00000395425   ENSP00000377837  
     ENSP00000400868   ENSP00000409915  
    Reactome Protein details: P07332

    FES Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FES Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FES
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FES
    GenScript Custom Purified and Recombinant Proteins Services for FES
    Novus Biologicals FES Proteins
    Novus Biologicals FES Lysate
    Sino Biological Recombinant Protein for FES
    Sino Biological Cell Lysate for FES
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FES

     
    Search eBioscience for Proteins for FES 

    FES Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FES
    Cell Signaling Technology (CST) Antibodies for FES 
    OriGene Antibodies for FES
    OriGene Custom Antibody Services for FES
    Novus Biologicals FES Antibodies
    Abcam antibodies for FES
    Cloud-Clone Corp. Antibodies for FES
    ThermoFisher Antibodies for FES
    LSBio Antibodies in human, mouse, rat for FES

    FES Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FES
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FES
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FES
    Cloud-Clone Corp. CLIAs for FES
    Search eBioscience for ELISAs for FES 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: feline sarcoma oncogene
    Fer family

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001060 FCH_dom
     IPR011009 Kinase-like_dom
     IPR016250 Tyr-prot_kinase_Fes/Fps
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P07332

    ProtoNet protein and cluster: P07332

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001060 Cdc15/Fes/CIP4
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FES_HUMAN, P07332
    Domain: The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization
    and probably also interaction with other proteins
    Domain: The N-terminal region including the first coiled coil domain mediates interaction with
    phosphoinositide-containing membranes
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with FES           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FES_HUMAN, P07332
    Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the
    regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in
    FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the
    activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of
    mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in
    response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced
    activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1,
    STAT3 and TRIM28
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Kinase activity is tightly regulated. Activated in response to signaling from a cell surface
    receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at
    Tyr-713. Present in an inactive form in the absence of activating stimuli

         Genatlas biochemistry entry for FES:
    feline sarcoma viral (v-fes) oncogene;Fujinami avian sarcoma viral (v-fps) oncogene homolog

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA11509660
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA15485904
    GO:0005515protein binding IPI18046454
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with FES           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FES:
     Decreased substrate adherent c  Decreased telomerase activity  Increased cell death HMECs cel  Weaker migration 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fes) (see all 16):
     cardiovascular system  craniofacial  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  normal  reproductive system  tumorigenesis 

    Find genes that share phenotypes with FES           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FES: Festm2Mcs Festm2Pag Festm1Mcs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FES
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FES
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FES

    miRNA
    Products:
        
    miRTarBase miRNAs that target FES:
    hsa-mir-26b-5p (MIRT029960)

    Block miRNA regulation of human, mouse, rat FES using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FES:
    hsa-miR-194* hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidFES 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FES
    Predesigned siRNA for gene silencing in human, mouse, rat FES

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FES

    Clone
    Products:
         
    OriGene clones in human, mouse for FES (see all 23)
    OriGene ORF clones in mouse, rat for FES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): FES (NM_001143783)
    Sino Biological Human cDNA Clone for FES
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FES
    Addgene plasmids for FES 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FES
    Browse ESI BIO Cell Lines and PureStem Progenitors for FES 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FES


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FES_HUMAN, P07332: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein;
    Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed
    throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the
    kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the
    lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular
    membrane structures in the cytoplasm and at the cell periphery
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    golgi apparatus5
    plasma membrane5
    nucleus3
    chloroplast2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11339827
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005925focal adhesion IDA18046454

    Find genes that share ontologies with FES           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FES About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Semaphorin interactions
    Semaphorin interactions0.43
    CRMPs in Sema3A signaling0.00
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.00
    Sema3A PAK dependent Axon repulsion0.00
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3PI-3K cascade
    Signaling by SCF-KIT0.72
    4Signaling by GPCR
    Signal Transduction0.58
    5Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42


    Find genes that share SuperPaths with FES           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FES
        Guidance Cues and Growth Cone Motility
    IL-4 Pathway
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for FES
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for FES
        Immune response IL-4 signaling pathway
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development EPO-induced Jak-STAT pathway

    Selected BioSystems Pathways for FES (see all 7)
        IL-4 signaling Pathway
    Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    IL-3 Signaling Pathway
    IL4-mediated signaling events


    4 Reactome Pathways for FES
        CRMPs in Sema3A signaling
    Sema3A PAK dependent Axon repulsion
    Signaling by SCF-KIT
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


    1 Kegg Pathway  (Kegg details for FES):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FES
    Interactions:

        GeneGlobe Interaction Network for FES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FES (P073321, 2, 3 ENSP000003315044) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153111, 2, 3, ENSP000003389344EBI-1055635,EBI-1056902 MINT-6380399 MINT-6380367 MINT-6380517 MINT-6380771 MINT-8035497 MINT-6380786 MINT-6380343 MINT-8035482 I2D: score=1 STRING: ENSP00000338934
    NSFP464592, 3, ENSP000003812934MINT-8217349 I2D: score=2 STRING: ENSP00000381293
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908171 I2D: score=1 STRING: ENSP00000365312
    PDE4DIPQ5VU432, 3MINT-8255310 I2D: score=2 
    EGFRP005332, 3, ENSP000002754934MINT-74535 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS6183005
    GO:0007275multicellular organismal development TAS6264598
    GO:0007411axon guidance TAS--
    GO:0008283cell proliferation TAS6264598
    GO:0008360regulation of cell shape IMP11509660

    Find genes that share ontologies with FES           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FES
      Browse compounds at ApexBio 

    Browse Tocris compounds for FES

    2 HMDB Compounds for FES    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for FES gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 69 90 8955135 (4), 8007965 (4), 7538109 (3), 7523858 (3) (see all 36)
    phosphotyrosine 51.3 1 7511210 (1)
    phosphatidylinositol 25 3 10405761 (1), 8007965 (1)
    retinoic acid 22.7 6 8152313 (2), 8340750 (1), 12642874 (1)
    threonine 15.2 1 8955135 (1)
    dmso 9.07 2 8340750 (1)
    agar 0 1 16455651 (1)
    serine 0 1 8955135 (1)



    Find genes that share compounds with FES           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FES gene (4 alternative transcripts): 
    NM_001143783.1  NM_001143784.1  NM_001143785.1  NM_002005.3  

    Unigene Cluster for FES:

    Feline sarcoma oncogene
    Hs.7636  [show with all ESTs]
    Unigene Representative Sequence: BC035357
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416779 ENST00000328850(uc002bpv.3 uc010uqj.2 uc010uqk.2 uc002bpx.3 uc002bpy.3 uc010bny.3)
    ENST00000470152 ENST00000414248 ENST00000481665 ENST00000559355 ENST00000394302
    ENST00000452243 ENST00000464684 ENST00000443697 ENST00000394300 ENST00000444422
    ENST00000497945 ENST00000494259 ENST00000448367 ENST00000496379 ENST00000462476
    ENST00000450438
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FES using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FES:
    hsa-miR-194* hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidFES 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FES
    Predesigned siRNA for gene silencing in human, mouse, rat FES
    Clone
    Products:
         
    OriGene clones in human, mouse for FES (see all 23)
    OriGene ORF clones in mouse, rat for FES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): FES (NM_001143783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FES
    Addgene plasmids for FES 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FES
    OriGene qSTAR qPCR primer pairs in human, mouse for FES
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FES
      QuantiTect SYBR Green Assays in human, mouse, rat FES
      QuantiFast Probe-based Assays in human, mouse, rat FES

    Additional mRNA sequence: 

    AK300595.1 AK300605.1 AK309530.1 AK312545.1 AY513654.1 AY513655.1 AY513656.1 AY513657.1 
    BC035357.1 M14209.1 X52192.1 

    9 DOTS entries:

    DT.211690  DT.95370630  DT.121041210  DT.121041225  DT.97839353  DT.100730102  DT.121041214  DT.121041217 
    DT.121041226 

    Selected AceView cDNA sequences (see all 85):

    NM_002005 BU179019 CA389238 BQ015500 BQ924403 BQ712558 CA449888 BU160929 
    CK429323 AU105452 CR622908 CR593957 BC035357 BM684264 CR624741 BM929822 
    BU538316 BX356089 CB850902 CB990282 AL602298 BI906370 BU191340 BU191031 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FES (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^
    SP1:                    -     -                 -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                            -     -     -     -     -     -     -                                                                           
    SP4:                    -     -                 -                                                                                                               
    SP5:                    -     -                 -                                   -     -     -     -     -     -           -     -     -     -     -     -   

    ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
    SP1:              -                 -                             -                                             
    SP2:                                -     -     -                 -                                             
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:  -           -                                                                                             


    ECgene alternative splicing isoforms for FES

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGTGCT
    FES Expression
    About this image

    FES Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FES Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7636

    UniProtKB/Swiss-Prot: FES_HUMAN, P07332
    Tissue specificity: Widely expressed. Detected in adult colon epithelium

        Custom PCR Arrays for FES
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FES
    OriGene qSTAR qPCR primer pairs in human, mouse for FES
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FES
    QuantiTect SYBR Green Assays in human, mouse, rat FES
    QuantiFast Probe-based Assays in human, mouse, rat FES
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FES gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fes1 , 5 feline sarcoma oncogene1, 5 87.1(n)1
    90.63(a)1
      7 (45.65 cM)5
    141591  NM_010194.21  NP_034324.21 
     803777585 
    chicken
    (Gallus gallus)
    Aves FES1 feline sarcoma oncogene 74.11(n)
    70.24(a)
      429374  XM_003641868.2  XP_003641916.2 
    lizard
    (Anolis carolinensis)
    Reptilia FES6
    feline sarcoma oncogene
    56(a)
    1 ↔ 1
    GL343759.1(99059-124728)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004891911 tyrosine-protein kinase transforming protein Fps-like 63.98(n)
    65.77(a)
      100489191  XM_002932240.2  XP_002932286.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130232 Transcribed sequence with weak similarity to protein more 77.89(n)    BI882025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fps85D3 photoreceptor morphogenesis (sensu
    Drosophila) more
    36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T21G5.13
    ZK622.11
    tyrosine-protein kinase3
    ZK622.11
    38(a)
    (best of 33)3
    44.63(n)1
    38.38(a)1
      I(6882444-6884994)3
    1913661  NM_062593.11  NP_494994.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC156
    Protein kinase of the Mitotic Exit Network that is...
    9(a)
    1 → many
    I(172211-175135) YAR019C


    ENSEMBL Gene Tree for FES (if available)
    TreeFam Gene Tree for FES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FES gene
    TEC2  DSTYK2  MATK2  BMX2  CSK2  FER2  ITK2  TXK2  
    BTK2  
    Selected SIMAP similar genes for FES using alignment to 10 protein entries:     FES_HUMAN (see all proteins) (see all similar genes):
    ABL1    BCR/ABL fusion    EPHA2    FER    EPHA3    EPHA5
    EPHA6    PTK2    BTK    EPHA4    EPHB2 variant protein    EPHB1
    EPHB3    FLT3    FLT4    MET    BTK kinase deficient isoform 6    FLT1

    Find genes that share paralogs with FES           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FES (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999420961,2
    C--67545463(+) AGCGGG/TTNNNN 4 -- int10--------
    rs342980471,2
    C,F--67549486(+) TGACA-/AGAGAG 4 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs62291,2
    C,F,H--71150123(+) CAAGGC/TCGAAG 2 -- us2k19Minor allele frequency- T:0.09MN NS EA WA 800
    rs1917007241,2
    --71150695(+) AGGTGA/GTGGCA 4 -- us2k10--------
    rs47021,2
    C,F,A,H--71150942(+) AAGATA/GCTGGG 4 -- us2k130Minor allele frequency- G:0.39MN EA NS NA WA CSA 4392
    rs1436699431,2
    C--71151008(+) TATTTA/GATGGA 4 -- us2k10--------
    rs781920201,2
    C,F--71151069(+) AACCAG/CGCCCA 4 -- us2k13Minor allele frequency- C:0.13NA CSA 124
    rs1113166971,2
    C--71151070(+) ACCAGA/GCCCAG 4 -- us2k10--------
    rs1132727431,2
    C--71151071(+) CCAGGA/CCCAGT 4 -- us2k10--------
    rs795964571,2
    C,F--71151115(+) CTGAGG/CATAGG 4 -- us2k13Minor allele frequency- C:0.13NA CSA 124

    HapMap Linkage Disequilibrium report for FES (91426925 - 91439006 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FES:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    nsv515661CNV Loss19592680
    dgv2436n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FES
    DNA2.0 Custom Variant and Variant Library Synthesis for FES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 190030    OMIM disorders: --

    UniProtKB/Swiss-Prot: FES_HUMAN, P07332
  • Note=Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation
    of the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as
    activated kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells
    (PubMed:20111072). Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid
    differentiation (PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or
    absent in samples from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses
    anchorage-independent growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and
    might be a predictor of recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma
    cells (PubMed:19082481)

  • 2 diseases for FES:    
    About MalaCards
    sarcoma    acute promyelocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for FES:
    Sarcoma

    Find genes that share disorders with FES           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FES gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 69.2 10 8634335 (2), 1984516 (2), 10706130 (1), 10567558 (1) (see all 6)
    leukaemia lymphocytic 37.9 6 1984516 (2), 1373879 (2), 20030920 (1)
    leukemia 31.7 7 1984516 (3), 20030920 (2), 2010659 (1), 16792528 (1)
    leukemia promyelocytic acute 27.8 2 8340750 (1), 8152313 (1)
    myeloid leukemia chronic 23.7 3 1984516 (1), 15869408 (1)
    hemangioma 16.9 1 8792159 (1)
    sarcoma 14.9 3 7696187 (1), 17588535 (1)
    colorectal cancer 0 2 15867340 (1), 16455651 (1)
    tumors 0 15 15867340 (5), 7893977 (2), 2174659 (1), 2394839 (1) (see all 5)
    lymphoma 0 2 1373879 (2)

    Genetic Association Database (GAD): FES
    Human Genome Epidemiology (HuGE) Navigator: FES (7 documents)
    Tumor Gene Database (TGDB): FES

    Export disorders for FES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FES gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with FES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. (PubMed id 16455651)1, 2, 9 Delfino F.J.... Smithgall T.E. (J. Biol. Chem. 2006)
    2. Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells. (PubMed id 19082481)1, 2, 9 Kanda S.... Smithgall T.E. (Int. J. Oncol. 2009)
    3. Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. (PubMed id 19001085)1, 2, 9 McPherson V.A.... Craig A.W. (Mol. Cell. Biol. 2009)
    4. The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. (PubMed id 15485904)1, 2, 9 Laurent C.E.... Smithgall T.E. (Mol. Cell. Biol. 2004)
    5. The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase. (PubMed id 16792528)1, 2, 9 Delfino F.J.... Smithgall T.E. (Biochem. J. 2006)
    6. Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues. (PubMed id 8955135)1, 2, 9 Li J. and Smithgall T.E. (J. Biol. Chem. 1996)
    7. Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene. (PubMed id 2179816)1, 2, 9 Alcalay M.... Pelicci P.G. (Oncogene 1990)
    8. A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells. (PubMed id 11509660)1, 2, 9 Cheng H.Y.... Smithgall T.E. (Mol. Cell. Biol. 2001)
    9. Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. (PubMed id 18775312)1, 2, 9 Filippakopoulos P.... Knapp S. (Cell 2008)
    10. Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. (PubMed id 11339827)1, 2, 9 Zirngibl R.... Greer P.A. (Exp. Cell Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2242 HGNC: 3657 AceView: FES Ensembl:ENSG00000182511 euGenes: HUgn2242
    ECgene: FES Kegg: 2242 H-InvDB: FES

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FES Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FES Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FES gene:
    Search GeneIP for patents involving FES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore Purified and/or Recombinant FES Protein
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FES (Fes)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FES   OriGene RNAi products in human, mouse, rat for FES  
     OriGene qPCR primer pairs and template standards for FES   OriGene Protein Over-expression Lysate for FES  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FES  
     OriGene qSTAR qPCR primer pairs in human, mouse for FES   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FES   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FES   OriGene Custom Protein Services for FES  

     
     
     Block miRNA regulation of human, mouse, rat FES using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FES
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FES Predesigned siRNA for gene silencing in human, mouse, rat FES
     QuantiFast Probe-based Assays in human, mouse, rat FES QuantiTect SYBR Green Assays in human, mouse, rat FES
     Custom PCR Arrays for FES Search Chromatin IP Primers for FES
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FES  GeneGlobe Interaction Network for FES
     Regulatory tfbs in FES promoter
     GenScript Custom Purified and Recombinant Proteins Services for FES GenScript cDNA clones with any tag delivered in your preferred vector for FES
     GenScript Custom Assay Services for FES GenScript Custom overexpressing Cell Line Services for FES
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FES 

     Search Tocris compounds for FES
     Proteins for FES
     Cell Lysates for FES
     cDNA Clones for FES
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for FES
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FES antibodies
     FES proteins
     FES lysates
     Antibodies for FES
     See all of Abcam's Antibodies, Kits and Proteins for FES
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FES
     Antibodies for FES
     ELISAs for FES
     CLIAs for FES



     Browse ESI BIO Cell Lines and PureStem Progenitors for FES
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FES
     SwitchGear 3'UTR luciferase reporter plasmids for FES
     SwitchGear Promoter luciferase reporter plasmids for FES
     ThermoFisher Antibodies for FES
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FES
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FES
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FES
     LSBio Antibodies in human, mouse, rat for FES
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for FES
      Search eBioscience for proteins for FES
      Search eBioscience for elisas for FES
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FES gene at Home site.
    Version: 3.12.216 30 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4