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Aliases for FERMT3 Gene

Aliases for FERMT3 Gene

  • Fermitin Family Member 3 2 3
  • KIND3 3 4 6
  • URP2 3 4 6
  • Unc-112-Related Protein 2 3 4
  • MIG2-Like Protein 3 4
  • Kindlin-3 2 4
  • MIG2B 3 4
  • Fermitin Family Homolog 3 (Drosophila) 2
  • UNC-112 Related Protein 2 3
  • Fermitin Family Homolog 3 3
  • Kindlin 3 3
  • UNC112C 3
  • URP2SF 3
  • MIG2B, 6
  • Mig-2 3

External Ids for FERMT3 Gene

Summaries for FERMT3 Gene

Entrez Gene Summary for FERMT3 Gene

  • Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]

GeneCards Summary for FERMT3 Gene

FERMT3 (Fermitin Family Member 3) is a Protein Coding gene. Diseases associated with FERMT3 include leukocyte adhesion deficiency, type iii and leukocyte adhesion deficiency. GO annotations related to this gene include phospholipid binding and integrin binding. An important paralog of this gene is FERMT2.

UniProtKB/Swiss-Prot for FERMT3 Gene

  • Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).

  • Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.

Gene Wiki entry for FERMT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FERMT3 Gene

Genomics for FERMT3 Gene

Genomic Location for FERMT3 Gene

64,206,678 bp from pter
64,223,891 bp from pter
17,214 bases
Plus strand

Genomic View for FERMT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FERMT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FERMT3 Gene

Regulatory Elements for FERMT3 Gene

Proteins for FERMT3 Gene

  • Protein details for FERMT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fermitin family homolog 3
    Protein Accession:
    Secondary Accessions:
    • Q8IUA1
    • Q8N207
    • Q9BT48

    Protein attributes for FERMT3 Gene

    667 amino acids
    Molecular mass:
    75953 Da
    Quaternary structure:
    • Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails).

    Three dimensional structures from OCA and Proteopedia for FERMT3 Gene

    Alternative splice isoforms for FERMT3 Gene


neXtProt entry for FERMT3 Gene

Proteomics data for FERMT3 Gene at MOPED

Post-translational modifications for FERMT3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys353 and Lys590

Other Protein References for FERMT3 Gene

No data available for DME Specific Peptides for FERMT3 Gene

Domains for FERMT3 Gene

Gene Families for FERMT3 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing
  • FERMT :Fermitins

Protein Domains for FERMT3 Gene


  • The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain:
    • Q86UX7
  • Contains 1 FERM domain.:
    • Q86UX7
  • Contains 1 PH domain.:
    • Q86UX7
  • Belongs to the kindlin family.:
    • Q86UX7
genes like me logo Genes that share domains with FERMT3: view

Function for FERMT3 Gene

Molecular function for FERMT3 Gene

UniProtKB/Swiss-Prot Function: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.

Gene Ontology (GO) - Molecular Function for FERMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FERMT3: view
genes like me logo Genes that share phenotypes with FERMT3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FERMT3 Gene

Localization for FERMT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FERMT3 Gene

Cell projection, podosome. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FERMT3 Gene COMPARTMENTS Subcellular localization image for FERMT3 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FERMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome ISS --
GO:0016020 membrane IDA 19946888
GO:0030054 cell junction IEA --
GO:0042995 cell projection IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with FERMT3: view

Pathways for FERMT3 Gene

SuperPathways for FERMT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FERMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007159 leukocyte cell-cell adhesion IMP 19234460
GO:0007229 integrin-mediated signaling pathway IMP 19234460
GO:0033622 integrin activation IMP 19234460
GO:0033632 regulation of cell-cell adhesion mediated by integrin IMP 19234463
GO:0034446 substrate adhesion-dependent cell spreading IMP 19234460
genes like me logo Genes that share ontologies with FERMT3: view

No data available for Pathways by source for FERMT3 Gene

Transcripts for FERMT3 Gene

Unigene Clusters for FERMT3 Gene

Fermitin family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FERMT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: -
SP3: -
SP5: -

Relevant External Links for FERMT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FERMT3 Gene

mRNA expression in normal human tissues for FERMT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FERMT3 Gene

This gene is overexpressed in Whole Blood (24.0) and Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FERMT3 Gene

SOURCE GeneReport for Unigene cluster for FERMT3 Gene Hs.180535

mRNA Expression by UniProt/SwissProt for FERMT3 Gene

Tissue specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
genes like me logo Genes that share expressions with FERMT3: view

Orthologs for FERMT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FERMT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FERMT3 36
  • 99.2 (n)
  • 99.55 (a)
  • 100 (a)
(Bos Taurus)
Mammalia FERMT3 37
  • 94 (a)
(Canis familiaris)
Mammalia FERMT3 36
  • 90.55 (n)
  • 95.92 (a)
  • 95 (a)
(Mus musculus)
Mammalia Fermt3 36
  • 86.63 (n)
  • 93.67 (a)
Fermt3 16
Fermt3 37
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia FERMT3 37
  • 87 (a)
(Rattus norvegicus)
Mammalia Fermt3 36
  • 86.02 (n)
  • 93.36 (a)
(Anolis carolinensis)
Reptilia FERMT3 37
  • 70 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69069 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9754 36
(Danio rerio)
Actinopterygii FERMT3 (2 of 2) 37
  • 60 (a)
fermt3b 36
  • 64.74 (n)
  • 64.48 (a)
fermt3b 37
  • 63 (a)
zgc64101 36
fruit fly
(Drosophila melanogaster)
Insecta Fit1 37
  • 39 (a)
Fit2 37
  • 38 (a)
(Caenorhabditis elegans)
Secernentea unc-112 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
Species with no ortholog for FERMT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FERMT3 Gene

Gene Tree for FERMT3 (if available)
Gene Tree for FERMT3 (if available)

Paralogs for FERMT3 Gene

Paralogs for FERMT3 Gene

Selected SIMAP similar genes for FERMT3 Gene using alignment to 4 proteins: Pseudogenes for FERMT3 Gene

genes like me logo Genes that share paralogs with FERMT3: view

Variants for FERMT3 Gene

Sequence variations from dbSNP and Humsavar for FERMT3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs882146 -- 64,209,227(-) GGTCT(C/T)GGCTT intron-variant
rs882147 -- 64,209,217(-) TTTGG(A/T)GCTCA intron-variant
rs1011219 -- 64,205,924(-) GACAG(C/T)GGCCT upstream-variant-2KB
rs1544538 -- 64,220,868(-) CACTG(C/T)GCCAG intron-variant
rs2508208 -- 64,208,871(-) CAGAA(A/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FERMT3 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
esv33774 CNV Gain 17666407

Relevant External Links for FERMT3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for FERMT3 Gene

(1) OMIM Diseases for FERMT3 Gene (607901)


  • Leukocyte adhesion deficiency 3 (LAD3) [MIM:612840]: A disorder characterized by recurrent bacterial infections without pus formation, leukocytosis and major bleeding disorders. {ECO:0000269 PubMed:18779414, ECO:0000269 PubMed:19064721, ECO:0000269 PubMed:19234460, ECO:0000269 PubMed:19234463, ECO:0000269 PubMed:19617577}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FERMT3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with FERMT3: view

Publications for FERMT3 Gene

  1. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PMID: 12697302) Weinstein E.J. … Mazzarella R. (Biochim. Biophys. Acta 2003) 3 4 23
  2. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. (PMID: 12886250) Boyd R.S. … Dyer M.J.S. (Leukemia 2003) 3 4 23
  3. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. (PMID: 18779414) Mory A. … Alon R. (Blood 2008) 3 4 23
  4. LAD-1/variant syndrome is caused by mutations in FERMT3. (PMID: 19064721) Kuijpers T.W. … Baas F. (Blood 2009) 3 4 23
  5. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. (PMID: 19234460) Malinin N.L. … Byzova T.V. (Nat. Med. 2009) 3 4 23

Products for FERMT3 Gene

Sources for FERMT3 Gene

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