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FERMT3 Gene

protein-coding   GIFtS: 56
GCID: GC11P063975

Fermitin Family Member 3

(Previous name: fermitin family homolog 3 (Drosophila))
  See FERMT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fermitin Family Member 31 2     MIG-22
KIND32 3 5     UNC112C2
MIG2B2 3 5     URP2SF2
URP22 3 5     Fermitin Family Homolog 32
Unc-112-Related Protein 22 3     Kindlin 32
MIG2-Like Protein2 3     UNC-112 Related Protein 22
Fermitin Family Homolog 3 (Drosophila)1     Kindlin-33
kindlin-31     

External Ids:    HGNC: 231511   Entrez Gene: 837062   Ensembl: ENSG000001497817   OMIM: 6079015   UniProtKB: Q86UX73   

Export aliases for FERMT3 gene to outside databases

Previous GC identifers: GC11P063731 GC11P060302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FERMT3 Gene:
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation
and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by
this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the
membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion
deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct
isoforms. (provided by RefSeq, Jan 2010)

GeneCards Summary for FERMT3 Gene:
FERMT3 (fermitin family member 3) is a protein-coding gene. Diseases associated with FERMT3 include leukocyte adhesion deficiency, type iii, and leukocyte adhesion deficiency. GO annotations related to this gene include integrin binding and phospholipid binding. An important paralog of this gene is FERMT2.

UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
Function: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3
(ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial
cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By
similarity)
Function: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis

Gene Wiki entry for FERMT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FERMT3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   PPAR-gamma1   E2F-1   E2F   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFERMT3 promoter sequence
   Search Chromatin IP Primers for FERMT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FERMT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

FERMT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FERMT3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063975:  view genomic region     (about GC identifiers)

Start:
63,974,150 bp from pter      End:
63,991,363 bp from pter
Size:
17,214 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7 (See protein sequence)
Recommended Name: Fermitin family homolog 3  
Size: 667 amino acids; 75953 Da
Subunit: Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails) (By similarity)
1 PDB 3D structure from and Proteopedia for FERMT3:
2YS3 (3D)    
Secondary accessions: Q8IUA1 Q8N207 Q9BT48
Alternative splicing: 2 isoforms:  Q86UX7-1   Q86UX7-2   

Explore the universe of human proteins at neXtProt for FERMT3: NX_Q86UX7

Explore proteomics data for FERMT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys353, Lys590
  • Modification sites at PhosphoSitePlus

  • See FERMT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_113659.3  NP_848537.1  

    ENSEMBL proteins: 
     ENSP00000445778   ENSP00000339950   ENSP00000279227   ENSP00000438885   ENSP00000440209  

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    antibodies-online proteins for FERMT3 (4 products) 

     
    antibodies-online peptides for FERMT3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    FERMT: Fermitins

    5 InterPro protein domains:
     IPR019748 FERM_central
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR019749 Band_41_domain

    Graphical View of Domain Structure for InterPro Entry Q86UX7

    ProtoNet protein and cluster: Q86UX7

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
    Domain: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion
    of a PH domain
    Similarity: Belongs to the kindlin family
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with FERMT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: URP2_HUMAN, Q86UX7
    Function: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3
    (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial
    cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By
    similarity)
    Function: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding ISS--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FERMT3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FERMT3:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fermt3):
     cardiovascular system  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with FERMT3           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    URP2_HUMAN, Q86UX7: Cell projection, podosome (By similarity). Note=Present in the F-actin surrounding ring
    structure of podosomes, which are specialized adhesion structures of hematopoietic cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome ISS--
    GO:0030054cell junction IEA--
    GO:0042995cell projection IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with FERMT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FERMT3
    Interactions:

        Search GeneGlobe Interaction Network for FERMT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for FERMT3 (Q86UX73 ENSP000002792274) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    EXOSC10Q017803, ENSP000003661354I2D: score=3 STRING: ENSP00000366135
    LSM8O957773, ENSP000002492994I2D: score=4 STRING: ENSP00000249299
    AFAP1L1ENSP000002967214STRING: ENSP00000296721
    RHOUENSP000003556524STRING: ENSP00000355652
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007159leukocyte cell-cell adhesion IMP19234460
    GO:0033622integrin activation IMP19234460
    GO:0033632regulation of cell-cell adhesion mediated by integrin IMP19234463
    GO:0070527platelet aggregation ISS--

    Find genes that share ontologies with FERMT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FERMT3 (URP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FERMT3 gene (2 alternative transcripts): 
    NM_031471.5  NM_178443.2  

    Unigene Cluster for FERMT3:

    Fermitin family member 3
    Hs.180535  [show with all ESTs]
    Unigene Representative Sequence: NM_178443
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544997 ENST00000345728(uc001nym.2) ENST00000279227(uc001nyl.2)
    ENST00000541252 ENST00000541326 ENST00000546255 ENST00000540957 ENST00000545896
    ENST00000540554
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    Additional mRNA sequence: 

    AK093719.1 AY093951.1 AY093952.1 BC004347.1 BC013366.2 BC015584.2 

    10 DOTS entries:

    DT.101964595  DT.87016974  DT.120757766  DT.95111670  DT.120757795  DT.120757798  DT.95148306  DT.95224839 
    DT.100808071  DT.120757796 

    Selected AceView cDNA sequences (see all 151):

    BQ231388 BM551342 AA977169 BQ933425 BM558855 AY093952 BG491654 AX748276 
    AL709779 BM915812 BX357215 BM915231 BM916920 BQ072423 BM811384 BX395872 
    NM_031471 BC004347 BM559876 BX366139 BQ054370 BQ575858 BQ053531 BM009729 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FERMT3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                            -                                       
    SP2:                                                                                            -                                       
    SP3:                    -                                                                                                               
    SP4:                                                                                                                                    
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for FERMT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FERMT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCAAACG
    FERMT3 Expression
    About this image


    FERMT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Tonsil (Hematopoietic System)
     
     Dermis (Integumentary System)
    FERMT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FERMT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180535

    UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
    Tissue specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed
    in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FERMT3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fermt31 , 5 fermitin family homolog 3 (Drosophila)1, 5 86.63(n)1
    93.67(a)1
      19 (5.13 cM)5
    1081011  NM_153795.21  NP_722490.11 
     69989585 
    lizard
    (Anolis carolinensis)
    Reptilia FERMT36
    fermitin family member 3
    70(a)
    1 ↔ 1
    GL343555.1(378113-393833)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690692 hypothetical protein MGC69069 76.27(n)    BC059329.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641012 hypothetical protein MGC64101 74.95(n)   393878  BC064669.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fit16
    Fit26
    Fermitin 2
    39(a)
    38(a)
    many ↔ many
    many ↔ many
    3L(4103564-4107116)
    3L(17017428-17020217)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1126
    Protein UNC-112 (unc-112) mRNA, complete cds
    36(a)
    1 → many
    V(14691852-14696933) WBGene00006836


    ENSEMBL Gene Tree for FERMT3 (if available)
    TreeFam Gene Tree for FERMT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FERMT3 gene
    FERMT22  FERMT12  
    3 SIMAP similar genes for FERMT3 using alignment to 4 protein entries:     URP2_HUMAN (see all proteins):
    FERMT1    FERMT2    DTGCU2

    Find genes that share paralogs with FERMT3           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for FERMT3
    PGOHUM00000236985 PGOHUM00000237306 PGOHUM00000260610


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FERMT3 (see all 475)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219182951,2
    Cpathogenic163907363(+) TCCAGC/TGAAAG 4 R * stg10--------
    rs1383969191,2
    C--63891561(+) TCTAAC/TGTGAG 2 -- us2k10--------
    rs1911875981,2
    --63891662(+) TTGAGA/TTGGAG 2 -- us2k10--------
    rs1492404361,2
    --63891849(+) GTCTCA/GAACTC 2 -- us2k10--------
    rs1833005141,2
    --63891882(+) CCTCAA/GCCTCC 2 -- us2k10--------
    rs1880340021,2
    --63891885(+) CAACCC/TCCCAA 2 -- us2k10--------
    rs1920255721,2
    --63891981(+) CTGTCA/GCCCAG 2 -- us2k10--------
    rs1474422621,2
    --63892001(+) CAGTGA/GCGTGA 2 -- us2k10--------
    rs1846255391,2
    --63892034(+) CTCCCA/GGGTTC 2 -- us2k10--------
    rs1880863291,2
    --63892146(+) AGAGAC/TGGGGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FERMT3 (63974150 - 63991363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FERMT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195
    esv33774CNV Gain17666407

    Human Gene Mutation Database (HGMD): FERMT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FERMT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FERMT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607901   
    OMIM disorders: 612840  
    UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
  • Leukocyte adhesion deficiency 3 (LAD3) [MIM:612840]: A disorder characterized by recurrent bacterial
    infections without pus formation, leukocytosis and major bleeding disorders. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 4 diseases for FERMT3:    
    About MalaCards
    leukocyte adhesion deficiency, type iii    leukocyte adhesion deficiency    kindler syndrome    low renin hypertension

    4 diseases from the University of Copenhagen DISEASES database for FERMT3:
    Leukocyte adhesion deficiency     Glanzmann's thrombasthenia     leukocyte-adhesion deficiency syndrome     Osteopetrosis

    Find genes that share disorders with FERMT3           About GenesLikeMe

    Genetic Association Database (GAD): FERMT3

    Export disorders for FERMT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FERMT3 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with FERMT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. (PubMed id 19617577)1, 2, 9 Manevich-Mendelson E.... Alon R. (Blood 2009)
    2. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. (PubMed id 12886250)1, 2, 9 Boyd R.S.... Dyer M.J.S. (Leukemia 2003)
    3. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PubMed id 12697302)1, 2, 9 Weinstein E.J....Mazzarella R. (Biochim. Biophys. Acta 2003)
    4. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. (PubMed id 18779414)1, 2, 9 Mory A.... Alon R. (Blood 2008)
    5. LAD-1/variant syndrome is caused by mutations in FERMT3. (PubMed id 19064721)1, 2, 9 Kuijpers T.W.... Baas F. (Blood 2009)
    6. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. (PubMed id 19234460)1, 2, 9 Malinin N.L.... Byzova T.V. (Nat. Med. 2009)
    7. Genome-wide association study of the child behavior checklist dysregulation profile. (PubMed id 21784300)1, 4 Mick E....Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011)
    8. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. (PubMed id 19234463)1, 2 Svensson L.... Hogg N. (Nat. Med. 2009)
    9. URP2SF, a FERM and PH domain containing protein, regulates NF-kappaB and apoptosis. (PubMed id 18280249)1, 2 Wang L.... Ma D. (Biochem. Biophys. Res. Commun. 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83706 HGNC: 23151 AceView: URP2 Ensembl:ENSG00000149781 euGenes: HUgn83706
    ECgene: FERMT3 H-InvDB: FERMT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FERMT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FERMT3 gene:
    Search GeneIP for patents involving FERMT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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