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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FERMT3 Gene

protein-coding   GIFtS: 55
GCID: GC11P063975

fermitin family member 3

(Previous name: fermitin family homolog 3 (Drosophila) )
 Explore 12 diseases affiliated with
FERMT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FERMT3    

Aliases
for FERMT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fermitin Family Member 31 2     MGC109661
KIND31 2 3 5     Fermitin Family Homolog 3 (Drosophila)1
MIG2B1 2 3 5     URP2SF2
URP21 2 3 5     Fermitin Family Homolog 32
MIG-21 2     Kindlin 32
UNC112C1 2     UNC-112 Related Protein 22
Unc-112-Related Protein 22 3     Kindlin-33
MIG2-Like Protein2 3     

External Ids:    HGNC: 231511   Entrez Gene: 837062   Ensembl: ENSG000001497817   OMIM: 6079015   UniProtKB: Q86UX73   

Export aliases for FERMT3 gene to outside databases

Previous GC identifers: GC11P063731 GC11P060302


Summaries
for FERMT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FERMT3:
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and
thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene
has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane
skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency
syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
Function: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3
(ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial
cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)
Function: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis

Gene Wiki entry for FERMT3


Genomic Views
for FERMT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FERMT3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   PPAR-gamma1   E2F-1   E2F   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FERMT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FERMT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FERMT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

FERMT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FERMT3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063975:  view genomic region     (about GC identifiers)

Start:
 63,974,150 bp from pter      End:
 63,991,363 bp from pter
Size:
 17,214 bases      Orientation:
 plus strand

Proteins
for FERMT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7 (See protein sequence)
Recommended Name: Fermitin family homolog 3  
Size: 667 amino acids; 75953 Da
Subunit: Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails) (By similarity)
Subcellular location: Cell projection, podosome (By similarity). Note=Present in the F-actin surrounding ring structure
of podosomes, which are specialized adhesion structures of hematopoietic cells (By similarity)
1 PDB 3D structure from and Proteopedia for FERMT3:
2YS3 (3D)    
Secondary accessions: Q8IUA1 Q8N207 Q9BT48
Alternative splicing: 2 isoforms:  Q86UX7-1   Q86UX7-2   

Explore the universe of human proteins at neXtProt for FERMT3: NX_Q86UX7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UX7

    • FERMT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_113659.3  NP_848537.1  

    ENSEMBL proteins: 
     ENSP00000445778   ENSP00000339950   ENSP00000279227   ENSP00000438885   ENSP00000440209  

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    Uscn Proteins for FERMT3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome ISS--
    GO:0030054cell junction IEA--
    GO:0042995cell projection IEA--


    FERMT3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FERMT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FERMT3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019748 FERM_central
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR019749 Band_41_domain

    Graphical View of Domain Structure for InterPro Entry Q86UX7

    ProtoNet protein and cluster: Q86UX7

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
    Domain: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a
    PH domain
    Similarity: Belongs to the kindlin family
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PH domain


    Function
    for FERMT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
    Function: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3
    (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial
    cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)
    Function: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding ISS--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--


    FERMT3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FERMT3:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fermt3):
     cardiovascular system  digestive/alimentary  hematopoietic system  homeostasis/metabolism  integument 
     mortality/aging  nervous system  skeleton 

    FERMT3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FERMT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FERMT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for FERMT3 (Q86UX73 ENSP000002792274) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    EXOSC10Q017803, ENSP000003661354I2D: score=3 STRING: ENSP00000366135
    NAA38O957773, ENSP000002492994I2D: score=4 STRING: ENSP00000249299
    AFAP1L1ENSP000002967214STRING: ENSP00000296721
    RHOUENSP000003556524STRING: ENSP00000355652
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007159leukocyte cell-cell adhesion IMP19234460
    GO:0033622integrin activation IMP19234463
    GO:0033632regulation of cell-cell adhesion mediated by integrin IMP19234463
    GO:0070527platelet aggregation ISS--


    FERMT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FERMT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FERMT3
    Search CenterWatch for drugs/clinical trials and news about FERMT3 / URP2 

    Transcripts
    for FERMT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FERMT3 gene (2 alternative transcripts): 
    NM_031471.5  NM_178443.2  

    Unigene Cluster for FERMT3:

    Fermitin family member 3
    Hs.180535  [show with all ESTs]
    Unigene Representative Sequence: NM_178443
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544997 ENST00000345728(uc001nym.2) ENST00000279227(uc001nyl.2)
    ENST00000541252 ENST00000541326 ENST00000546255 ENST00000540957 ENST00000545896
    ENST00000540554

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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FERMT3
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    Additional cDNA sequence: 

    AK093719.1 AY093951.1 AY093952.1 BC004347.1 BC013366.2 BC015584.2 

    10 DOTS entries:

    DT.101964595  DT.87016974  DT.120757766  DT.95111670  DT.120757795  DT.120757798  DT.95148306  DT.95224839 
    DT.100808071  DT.120757796 

    24/151 AceView cDNA sequences (see all 151):

    BE466295 NM_178443 BG743988 CA433782 BG106426 AA353813 BU540512 BM919386 
    AY093951 BQ955033 BX366139 CR613949 CR621529 BG491654 BM480015 BM915812 
    BX395872 BC013366 AA977169 BX366140 AL709779 NM_031471 AY093952 BM914870 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FERMT3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                            -                                       
    SP2:                                                                                            -                                       
    SP3:                    -                                                                                                               
    SP4:                                                                                                                                    
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for FERMT3

    Expression
    for FERMT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FERMT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTCAAACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FERMT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod PeriosteumBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium

    See FERMT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FERMT3

    SOURCE GeneReport for Unigene cluster: Hs.180535

    UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
    Tissue specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in
    placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies

        SABiosciences Custom PCR Arrays for FERMT3
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    In Situ
    Assay Products:     
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    Orthologs
    for FERMT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FERMT3 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia FERMT36
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL343555.1(380027-391722)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC690692 hypothetical protein MGC69069 76.27(n)    BC059329.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc641012 hypothetical protein MGC64101 74.95(n)   393878  BC064669.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Fit16
    Fit26
    		 Fermitin 2
    		 39(a)
    38(a)
    		 many ↔ many
    many ↔ many
    		 3L(4103564-4107116)
    3L(17017428-17020217)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-1126
    		 Protein unc-112
    		 36(a)
    		 1 → many
    		 V(14691837-14696918)


    ENSEMBL Gene Tree for FERMT3 (if available)
    TreeFam Gene Tree for FERMT3 (if available) 

    Paralogs
    for FERMT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FERMT3 gene
    FERMT22  FERMT12  
    3 SIMAP similar genes for FERMT3 using alignment to 4 protein entries:     URP2_HUMAN (see all proteins):
    FERMT1    FERMT2    DTGCU2

    FERMT3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FERMT3
    PGOHUM00000236985 PGOHUM00000237306 PGOHUM00000260610


    Genomic Variants
    for FERMT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/359 NCBI SNPs in FERMT3 are shown (see all 359)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219182951,2
    		Cpathogenic63988121(+) TCCAGC/TGAAAG 4 R * stg10--------
    rs1492404361,2
    		--63972607(+) GTCTCA/GAACTC 2 -- us2k10--------
    rs1833005141,2
    		--63972640(+) CCTCAA/GCCTCC 2 -- us2k10--------
    rs1880340021,2
    		--63972643(+) CAACCC/TCCCAA 2 -- us2k10--------
    rs1920255721,2
    		--63972739(+) CTGTCA/GCCCAG 2 -- us2k10--------
    rs1474422621,2
    		--63972759(+) CAGTGA/GCGTGA 2 -- us2k10--------
    rs1846255391,2
    		--63972792(+) CTCCCA/GGGTTC 2 -- us2k10--------
    rs1880863291,2
    		--63972904(+) AGAGAC/TGGGGT 2 -- us2k10--------
    rs1927316901,2
    		--63972915(+) TTCACC/TGTGTT 2 -- us2k10--------
    rs1850587281,2
    		--63972916(+) TCACCA/GTGTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FERMT3 (63974150 - 63991363 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FERMT3
         1 Indel: 11056
    Human Gene Mutation Database (HGMD): FERMT3

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    Disorders / Diseases
    for FERMT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FERMT3 for disorders           About GeneDecksing

    OMIM gene information: 607901   
    OMIM disorders: 612840  
    UniProtKB/Swiss-Prot: URP2_HUMAN, Q86UX7
  • Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called
    • leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus
    formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a
    hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on
    hematopoietic cells, including platelets and leukocytes

    12 diseases for FERMT3:    About MalaCards
    leukocyte adhesion deficiency, type iii    phagocyte bactericidal dysfunction    leukocyte-adhesion deficiency syndrome    kindler syndrome
    thrombosis    chronic lymphocytic leukemia    lymphocytic leukemia    bleeding disorder
    osteopetrosis    colon carcinoma    leukemia    carcinoma

    4 diseases from the University of Copenhagen DISEASES database for FERMT3:
    Leukocyte adhesion deficiency     Glanzmann's thrombasthenia     leukocyte-adhesion deficiency syndrome     Osteopetrosis

    Export disorders for FERMT3 gene to outside databases

    Publications
    for FERMT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FERMT3 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with FERMT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. (PubMed id 19617577)1, 2, 9 Manevich-Mendelson E.... Alon R. (2009)
    2. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. (PubMed id 12886250)1, 2, 9 Boyd R.S.... Dyer M.J.S. (2003)
    3. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PubMed id 12697302)1, 2, 9 Weinstein E.J....Mazzarella R. (2003)
    4. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. (PubMed id 18779414)1, 2, 9 Mory A.... Alon R. (2008)
    5. LAD-1/variant syndrome is caused by mutations in FERMT3. (PubMed id 19064721)1, 2, 9 Kuijpers T.W.... Baas F. (2009)
    6. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. (PubMed id 19234460)1, 2, 9 Malinin N.L....Byzova T.V. (2009)
    7. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. (PubMed id 19234463)1, 2 Svensson L.... Hogg N. (2009)
    8. URP2SF, a FERM and PH domain containing protein, regulates NF-kappaB and apoptosis. (PubMed id 18280249)1, 2 Wang L.... Ma D. (2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for FERMT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing FERMT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83706 HGNC: 23151 AceView: URP2 Ensembl:ENSG00000149781 euGenes: HUgn83706
    ECgene: FERMT3 H-InvDB: FERMT3

    Other Databases showing FERMT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FERMT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FERMT3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FERMT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FERMT3 gene:
    Search GeneIP for patents involving FERMT3

    GeneCards and IP:
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