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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FERMT2 Gene

protein-coding   GIFtS: 56
GCID: GC14M053323

fermitin family member 2

(Previous names: pleckstrin homology domain containing, family C (with FERM...)
(Previous symbol: PLEKHC1)
 Explore 9 diseases affiliated with
FERMT2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FERMT2    

Aliases
for FERMT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fermitin Family Member 21 2     UNC1122 5
KIND21 2 3 5     Fermitin Family Homolog 2 (Drosophila)1
PLEKHC11 2 3 5     Fermitin Family Homolog 22
MIG22 3 5     Kindlin 22
UNC112B1 2     Kindlin-23
Mig-21     Mitogen Inducible Gene 2 Protein2
Pleckstrin Homology Domain Containing, Family C (With FERM Domain) Member 11 2     Pleckstrin Homology Domain Containing, Family C Member 12
Mitogen-Inducible Gene 2 Protein2 3     Kindlin-23
Pleckstrin Homology Domain-Containing Family C Member 12 3     MIG-23
PH Domain-Containing Family C Member 12 3     

External Ids:    HGNC: 157671   Entrez Gene: 109792   Ensembl: ENSG000000737127   OMIM: 6077465   UniProtKB: Q96AC13   

Export aliases for FERMT2 gene to outside databases

Previous GC identifers: GC14M052394 GC14M033486


Summaries
for FERMT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: FERM2_HUMAN, Q96AC1
Function: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the
orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal
adhesion sites

Gene Wiki entry for FERMT2


Genomic Views
for FERMT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FERMT2 gene promoter:
         SREBP-1c   FOXD3   HNF-1A   SREBP-1b   Egr-2   SREBP-1a   deltaCREB   HNF-1   SEF-1 (1)   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FERMT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FERMT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FERMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

FERMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FERMT2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M053323:  view genomic region     (about GC identifiers)

Start:
 53,323,986 bp from pter      End:
 53,419,153 bp from pter
Size:
 95,168 bases      Orientation:
 minus strand

Proteins
for FERMT2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FERM2_HUMAN, Q96AC1 (See protein sequence)
Recommended Name: Fermitin family homolog 2  
Size: 680 amino acids; 77861 Da
Subunit: Interacts with FBLP1
Subcellular location: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Within actin
stress fibers at cell-ECM focal adhesion sites
Sequence caution: Sequence=CAA80852.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for FERMT2:
2LGX (3D)        2LKO (3D)        4F7H (3D)    
Secondary accessions: B5TJY2 Q14840 Q86TY7
Alternative splicing: 3 isoforms:  Q96AC1-1   Q96AC1-2   Q96AC1-3   (May be due to an exon inclusion and an intron retention)

Explore the universe of human proteins at neXtProt for FERMT2: NX_Q96AC1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96AC1

    • FERMT2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128471.1  NP_001128472.1  NP_006823.1  

    ENSEMBL proteins: 
     ENSP00000378993   ENSP00000340391   ENSP00000450741   ENSP00000451084   ENSP00000451134  
     ENSP00000382243   ENSP00000451268   ENSP00000452472   ENSP00000450506   ENSP00000451085  
     ENSP00000342858  
    Reactome Protein details: Q96AC1
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: FERMT2
    OriGene Protein Over-expression Lysate: FERMT2
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    Novus Biologicals FERMT2 Protein
    Novus Biologicals FERMT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FERMT2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber NAS--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion IDA--


    FERMT2 for ontologies           About GeneDecksing



    FERMT2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FERMT2
    R&D Systems Antibodies for FERMT2 (MIG2)
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    Novus Biologicals FERMT2 Antibodies
    Search for Antibodies for FERMT2 at Abcam  
    Uscn Antibodies for FERMT2
    Search ThermoFisher Antibodies for FERMT2

    Assay Products for FERMT2: 
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    Uscn ELISAs and CLIAs for FERMT2

    Protein Domains /
    Families
    for FERMT2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FERMT2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR019748 FERM_central
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR019749 Band_41_domain

    Graphical View of Domain Structure for InterPro Entry Q96AC1

    ProtoNet protein and cluster: Q96AC1

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: FERM2_HUMAN, Q96AC1
    Domain: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a
    PH domain
    Similarity: Belongs to the kindlin family
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PH domain


    Function
    for FERMT2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FERM2_HUMAN, Q96AC1
    Function: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the
    orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal
    adhesion sites
    Induction: By serum in lung fetal fibroblast cultured cells

    miRNA
    Products:            		miRTarBase miRNAs that target FERMT2:
    hsa-mir-1 (MIRT005281)

    OriGene 3'-UTR Clone (see all 3): FERMT2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FERMT2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate FERMT2 (see all 49):
    hsa-miR-323-3p hsa-miR-582-3p hsa-miR-376b hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: FERMT2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FERMT2 (see all 4)
    OriGene shRNA RFP: FERMT2
    OriGene siRNA: FERMT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FERMT2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FERMT2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FERMT2 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 3): FERMT2 (NM_001134999)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FERMT2 

    Cell Line
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    Search LifeMap BioReagents cell lines for FERMT2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FERMT2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--


    FERMT2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FERMT2:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Fermt2tm1Ref for FERMT2
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fermt2):
     cellular  embryogenesis  mortality/aging 

    FERMT2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FERMT2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    		Cell-extracellular matrix interactions0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for FERMT2
        Cell-extracellular matrix interactions
    Cell junction organization
    Cell-Cell communication



    FERMT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FERMT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for FERMT2 (Q96AC12, 3 ENSP000003428584) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352222MINT-8399030 MINT-8398724 MINT-8398831 MINT-8398987 MINT-8398882 MINT-8398896 MINT-8398917 MINT-8398737 MINT-8399014 MINT-8398779 MINT-8399000 MINT-8398937 MINT-8398816 MINT-8398862 MINT-8398799 MINT-8398846 MINT-8398755
    TCF4P158842MINT-8398937 MINT-8399030 MINT-8398862 MINT-8398882 MINT-8398896 MINT-8398917 MINT-8398954
    FBLIM1Q8WUP23, ENSP000004163874I2D: score=2 STRING: ENSP00000416387
    PARVAQ9NVD73, ENSP000003340084I2D: score=1 STRING: ENSP00000334008
    ARAFP103983I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS--
    GO:0008360regulation of cell shape IEA--
    GO:0030036actin cytoskeleton organization NAS--
    GO:0034329cell junction assembly TAS--


    FERMT2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FERMT2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FERMT2
    Search CenterWatch for drugs/clinical trials and news about FERMT2 / FERM2 

    Transcripts
    for FERMT2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FERMT2 gene (3 alternative transcripts): 
    NM_001134999.1  NM_001135000.1  NM_006832.2  

    Unigene Cluster for FERMT2:

    Fermitin family member 2
    Hs.509343  [show with all ESTs]
    Unigene Representative Sequence: NM_001134999
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395631(uc001xad.3) ENST00000341590(uc001xae.3) ENST00000557255
    ENST00000554152 ENST00000555546 ENST00000553373 ENST00000553663 ENST00000399304(uc001xaf.3)
    ENST00000553768 ENST00000554288 ENST00000555692 ENST00000554712 ENST00000557562
    ENST00000343279(uc001xac.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FERMT2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate FERMT2 (see all 49):
    hsa-miR-323-3p hsa-miR-582-3p hsa-miR-376b hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: FERMT2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FERMT2 (see all 4)
    OriGene shRNA RFP: FERMT2
    OriGene siRNA: FERMT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FERMT2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FERMT2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FERMT2 (NM_001134999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FERMT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FERMT2 
    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FERMT2

    Additional cDNA sequence: 

    AF443279.1 AK126426.1 AK291738.1 BC011125.1 BC017327.2 BX161467.1 EU979385.1 Z24725.1 

    13 DOTS entries:

    DT.95229891  DT.100812360  DT.99979568  DT.40206342  DT.100024323  DT.120771632  DT.100718988  DT.99938480 
    DT.91760946  DT.91760965  DT.95310000  DT.75101300  DT.99973191 

    24/174 AceView cDNA sequences (see all 174):

    BG435558 BX464883 BQ437790 AA444033 NM_006832 AA364982 BX161467 BC017327 
    BU188003 CB265794 AW271443 AI627283 CR624174 T28567 BX398816 AF443279 
    T16775 BX330544 AI224965 AA446538 AI355335 AV703349 BE501451 AI808833 

    GeneLoc Exon Structure


    Expression
    for FERMT2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FERMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTCAAAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FERMT2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteLumbar Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See FERMT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FERMT2

    SOURCE GeneReport for Unigene cluster: Hs.509343

    UniProtKB/Swiss-Prot: FERM2_HUMAN, Q96AC1
    Tissue specificity: Ubiquitous. Found in numerous tumor tissues

        SABiosciences Custom PCR Arrays for FERMT2
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FERMT2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FERMT2

    Orthologs
    for FERMT2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FERMT2 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PLEKHC11 pleckstrin homology domain containing, family C (with more 80.4(n)
    95.78(a)    		   423589  XM_421477.3  XP_421477.3 
    lizard
    (Anolis carolinensis)    		 Reptilia FERMT26
    FERMT26
    		 --
    		 96(a)
    79(a)
    		 possible ortholog
    1 ↔ 1
    		 GL343527.1(107140-151263)
    AAWZ02038193(7953-9445)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.33922 Xenopus laevis transcribed sequence with strong similarity more 84.32(n)    CA971258.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fermt21 fermitin family homolog 2 (Drosophila) 76.75(n)
    91.52(a)    		   553051  XM_680444.4  XP_685536.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Fit11 Fermitin 1 55.49(n)
    52.15(a)    		   38488  NM_168060.2  NP_728936.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-1121 Protein UNC-112 52.86(n)
    46.43(a)    		   179972  NM_074227.5  NP_506628.1 


    ENSEMBL Gene Tree for FERMT2 (if available)
    TreeFam Gene Tree for FERMT2 (if available) 

    Paralogs
    for FERMT2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FERMT2 gene
    FERMT32  FERMT12  
    3 SIMAP similar genes for FERMT2 using alignment to 7 protein entries:     FERM2_HUMAN (see all proteins):
    FERMT1    DTGCU2    FERMT3

    FERMT2 for paralogs           About GeneDecksing



    Genomic Variants
    for FERMT2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1711 NCBI SNPs in FERMT2 are shown (see all 1711)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs733007691,2
    		C,--53323594(+) AATTGG/TTCTAA 2 -- ds50012Minor allele frequency- T:0.12WA 120
    rs1381792881,2
    		--53323819(+) TTCAAC/TTGAGG 2 -- ds50010--------
    rs1866825241,2
    		--53323963(+) TGTAAA/CCATTA 2 -- ds50010--------
    rs1495636811,2
    		--53324140(+) ACAGAG/TTGTAA 2 -- ut310--------
    rs1907931191,2
    		--53324150(+) ACAGCA/GCAACA 2 -- ut310--------
    rs758422231,2
    		F,--53324265(+) ATTATA/CTCTCT 2 -- ut311Minor allele frequency- C:0.05NA 120
    rs1812605811,2
    		--53324288(+) ATTAAC/TGCAGA 2 -- ut310--------
    rs1857028681,2
    		--53324308(+) ATTTAA/GGCCAT 2 -- ut310--------
    rs799480141,2
    		C,--53324425(+) ATGCA-/AAGAGTT 2 -- ut310--------
    rs1442088531,2
    		--53324478(+) AAAGTA/GTAATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FERMT2 (53323986 - 53419153 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FERMT2
         1 Indel: 58679

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    Disorders / Diseases
    for FERMT2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FERMT2 for disorders           About GeneDecksing

    OMIM gene information: 607746    OMIM disorders: --

    9 diseases for FERMT2:    About MalaCards
    kindler syndrome    malignant mesothelioma    osteopetrosis    leiomyosarcoma
    chondrosarcoma    leiomyoma    colon carcinoma    breast cancer
    carcinoma


    Export disorders for FERMT2 gene to outside databases

    Publications
    for FERMT2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FERMT2 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with FERMT2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PubMed id 12697302)1, 2, 3 Weinstein E.J....Mazzarella R. (2003)
    2. Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression. (PubMed id 8175911)1, 2, 3 Wick M.... Mueller R. (1994)
    3. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. (PubMed id 12679033)1, 2, 9 Tu Y.... Wu C. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    6. Kindlin-2 (Mig-2): a co-activator of beta3 integrins. (PubMed id 18458155)1, 9 Ma Y.Q....Plow E.F. (2008)
    7. Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas. (PubMed id 14745725)1, 9 Kato K....Konishi I. (2004)
    8. Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. (PubMed id 18528435)1, 9 Lai-Cheong J.E....McGrath J.A. (2008)
    9. The role of kindlins in cell biology and relevance to human disease. (PubMed id 19854292)1, 9 Lai-Cheong J.E....McGrath J.A. (2010)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for FERMT2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing FERMT2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10979 HGNC: 15767 AceView: PLEKHC1 Ensembl:ENSG00000073712 euGenes: HUgn10979
    ECgene: FERMT2 H-InvDB: FERMT2

    Other Databases showing FERMT2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FERMT2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FERMT2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/FERMT2

    Intellectual Property
    for FERMT2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FERMT2 gene:
    Search GeneIP for patents involving FERMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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