Aliases for FERMT2 Gene
- Fermitin Family Member 2 2 3
- Kindlin-2 2 3 4
- PLEKHC1 3 4 6
- KIND2 3 4 6
- MIG2 3 4 6
- Pleckstrin Homology Domain Containing, Family C (With FERM Domain) Member 1 2 3
- Pleckstrin Homology Domain-Containing Family C Member 1 3 4
- PH Domain-Containing Family C Member 1 3 4
- Mitogen-Inducible Gene 2 Protein 3 4
External Ids for FERMT2 Gene
Previous Symbols for FERMT2 Gene
GeneCards Summary for FERMT2 Gene
FERMT2 (Fermitin Family Member 2) is a Protein Coding gene. Diseases associated with FERMT2 include kindler syndrome. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is FERMT3.
UniProtKB/Swiss-Prot for FERMT2 Gene
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.