Aliases for FERMT1 Gene
Aliases for FERMT1 Gene
External Ids for FERMT1 Gene
- HGNC: 15889
- Entrez Gene: 55612
- Ensembl: ENSG00000101311
- OMIM: 607900
- UniProtKB: Q9BQL6
Previous HGNC Symbols for FERMT1 Gene
- C20orf42
Previous GeneCards Identifiers for FERMT1 Gene
- GC20M006004
- GC20M006055
Summaries for FERMT1 Gene
-
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]
GeneCards Summary for FERMT1 Gene
FERMT1 (Fermitin Family Member 1) is a Protein Coding gene. Diseases associated with FERMT1 include Kindler Syndrome and Hereditary Acrokeratotic Poikiloderma, Weary Type. Among its related pathways are Adhesion and Cytoskeletal Signaling. An important paralog of this gene is FERMT3.
UniProtKB/Swiss-Prot for FERMT1 Gene
-
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FERMT1 Gene
Genomics for FERMT1 Gene
Regulatory Elements for FERMT1 Gene
Enhancers for FERMT1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FERMT1 on UCSC Golden Path with GeneCards custom track
Promoters for FERMT1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around FERMT1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FERMT1 gene promoter:
Regulatory Element Products
Genomic Location for FERMT1 Gene
- Chromosome:
- 20
- Start:
- 6,074,845 bp from pter
- End:
- 6,123,544 bp from pter
- Size:
- 48,700 bases
- Orientation:
- Minus strand
Genomic View for FERMT1 Gene
Genes around FERMT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p12.3 by Ensembl
- 20p12.3 by Entrez Gene
- 20p12.3 by HGNC
FERMT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FERMT1 Gene
Proteins for FERMT1 Gene
-
Protein details for FERMT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQL6-FERM1_HUMAN
- Recommended name:
- Fermitin family homolog 1
- Protein Accession:
- Q9BQL6
- D3DW10
- Q8IX34
- Q8IYH2
- Q9NWM2
- Q9NXQ3
Protein attributes for FERMT1 Gene
- Size:
- 677 amino acids
- Molecular mass:
- 77437 Da
- Quaternary structure:
-
- Interacts with the cytoplasmic domain of integrins ITGB1 and ITGB3.
- SequenceCaution:
-
- Sequence=BAA91358.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03826.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FERMT1 Gene
Post-translational modifications for FERMT1 Gene
Other Protein References for FERMT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FERMT1
- Cell Signaling Technology (CST) Antibodies for FERMT1 (kindlin-1)
- Novus Biologicals Antibodies for FERMT1
- Invitrogen Antibodies for FERMT1
- antibodies-online Antibodies for FERMT1: See all 48
- GeneTex FERMT1 antibody for FERMT1
Protein Products
-
OriGene Purified Proteins for FERMT1
- Search Origene for MassSpec and Protein Over-expression Lysates for FERMT1
- Origene Custom Protein Services for FERMT1
- antibodies-online Proteins for FERMT1: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FERMT1
Assay Products
No data available for DME Specific Peptides for FERMT1 Gene
Domains & Families for FERMT1 Gene
Gene Families for FERMT1 Gene
Protein Domains for FERMT1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FERMT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BQL6UniProtKB/Swiss-Prot:
FERM1_HUMAN :- The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions.
- Belongs to the kindlin family.
- Domain:
-
- The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions.
- Contains 1 FERM domain.
- Contains 1 PH domain.
- Family:
-
- Belongs to the kindlin family.
Function for FERMT1 Gene
Molecular function for FERMT1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
- UniProtKB/Swiss-Prot Induction:
- By TGFB1.
Phenotypes for FERMT1 Gene
- MGI mutant phenotypes for FERMT1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FERMT1:
-
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Models for FERMT1 Gene
- MGI Knock Outs for FERMT1:
-
- Fermt1 tm1Ref
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FERMT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FERMT1 gene
- Search ViGene Biosciences for FERMT1
CRISPR Products
-
OriGene CRISPR knockouts for FERMT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FERMT1
- GenScript: Design CRISPR guide RNA sequences for FERMT1
miRNA for FERMT1 Gene
- miRTarBase miRNAs that target FERMT1
miRNA Products
- Search ViGene Biosciences for FERMT1
Clone Products
- OriGene clones in human for FERMT1
- OriGene ORF clones in human,mouse,rat for FERMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FERMT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FERMT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FERMT1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FERMT1 Gene
Localization for FERMT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FERMT1 Gene
- Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| plasma membrane | 5 |
| nucleus | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030054 | cell junction | IDA | 17012746 |
| GO:0031941 | filamentous actin | IEA | -- |
Pathways & Interactions for FERMT1 Gene
More details on SuperPathways for FERMT1| Superpath | Contained pathways | |
|---|---|---|
| 1 | Adhesion |
1
|
| 2 | Cytoskeletal Signaling |
Pathways by source for FERMT1 Gene
2 Cell Signaling Technology pathways for FERMT1 Gene
Interacting Proteins for FERMT1 Gene
Selected Interacting proteins:
Q9BQL6-FERM1_HUMAN
ENSP00000217289
for FERMT1 Gene via
MINT
STRING
I2D
No data available for SIGNOR curated interactions for FERMT1 Gene
Transcripts for FERMT1 Gene
mRNA/cDNA for FERMT1 Gene
- (1) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (121) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FERMT1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FERMT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FERMT1
- GenScript: Design CRISPR guide RNA sequences for FERMT1
miRNA Products
- Search ViGene Biosciences for FERMT1
Clone Products
- OriGene clones in human for FERMT1
- OriGene ORF clones in human,mouse,rat for FERMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for FERMT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for FERMT1 Gene
This gene is overexpressed in Adrenal Gland (x7.6), Esophagus - Mucosa (x5.9), Colon - Transverse (x4.8), Skin - Not Sun Exposed (Suprapubic) (x4.2), and Skin - Sun Exposed (Lower leg) (x4.2).
This gene is overexpressed in Heart (39.4) and Adrenal (13.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FERMT1 Gene
SOURCE GeneReport for Unigene cluster for FERMT1 Gene Hs.472054
mRNA Expression by UniProt/SwissProt for FERMT1 Gene
Q9BQL6-FERM1_HUMAN
Tissue specificity:
Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.
Primer Products
-
OriGene qPCR primer pairs for FERMT1
Orthologs for FERMT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | FERMT1 35 |
|
||
| FERMT1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | FERMT1 35 |
|
||
| FERMT1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Fermt1 35 |
|
||
| Fermt1 16 |
|
||||
| Fermt1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | FERMT1 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fermt1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FERMT1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FERMT1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FERMT1 35 |
|
||
| FERMT1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FERMT1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fermt1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fermt1 35 |
|
||
| fermt1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Fit1 36 |
|
ManyToMany | |
| Fit2 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | unc-112 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for FERMT1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FERMT1 Gene
(3) SIMAP similar genes for FERMT1 Gene using alignment to 4 proteins:
Variants for FERMT1 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2232074 | - | 6,085,082(-) | AAAAA(A/G)ACACA | reference, missense | |
| rs2232078 | - | 6,084,158(-) | TGGCC(A/G)CCCGG | reference, missense | |
| rs16991866 | - | 6,112,530(+) | CAATT(A/G)TGGGT | reference, missense | |
| rs55666319 | - | 6,110,322(+) | TATCA(A/G)CCAGA | reference, missense | |
| VAR_066943 | Kindler syndrome (KINDS) |
Residual Variation Intolerance Score:
23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.78;
97.36% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FERMT1 Gene
- Human Gene Mutation Database (HGMD)
- FERMT1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FERMT1 Gene
Disorders for FERMT1 Gene
(5) MalaCards diseases for FERMT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kindler syndrome |
|
|
| hereditary acrokeratotic poikiloderma, weary type |
|
|
| skin atrophy |
|
|
| photoparoxysmal response 1 |
|
|
| urbach-wiethe disease |
|
|
Search FERMT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FERM1_HUMAN- Kindler syndrome (KINDS) [MIM:173650]: Autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. {ECO:0000269 PubMed:12668616, ECO:0000269 PubMed:12789646, ECO:0000269 PubMed:21936020}. Note=The disease is caused by mutations affecting the gene represented in this entry. Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020). {ECO:0000269 PubMed:21936020}.
Relevant External Links for FERMT1
No data available for Genatlas for FERMT1 Gene
Publications for FERMT1 Gene
- URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PMID: 12697302) Weinstein E.J. … Mazzarella R. (Biochim. Biophys. Acta 2003) 2 3 4 23 67
- Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. (PMID: 12789646) Siegel D.H. … Epstein E.H. Jr. (Am. J. Hum. Genet. 2003) 2 3 23
- The role of kindlins in cell biology and relevance to human disease. (PMID: 19854292) Lai-Cheong J.E. … McGrath J.A. (Int. J. Biochem. Cell Biol. 2010) 3 23
- Kindler syndrome pathogenesis and fermitin family homologue 1 (kindlin-1) function. (PMID: 19945623) D'Souza M.A. … McMillan J.R. (Dermatol Clin 2010) 3 23
- Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. (PMID: 19762715) Has C. … Bruckner-Tuderman L. (Am. J. Pathol. 2009) 3 23
Products for FERMT1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FERMT1
- Search Origene for MassSpec and Protein Over-expression Lysates for FERMT1
- Origene Custom Protein Services for FERMT1
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for FERMT1
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- OriGene qPCR primer pairs for FERMT1
- OriGene CRISPR knockouts for FERMT1
- OriGene clones in human for FERMT1
- OriGene ORF clones in human,mouse,rat for FERMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for FERMT1
- GenScript Custom Assay Services for FERMT1
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- GenScript: Design CRISPR guide RNA sequences for FERMT1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FERMT1
- Cell Signaling Technology (CST) Antibodies for FERMT1 (kindlin-1)
- Search for Antibodies & Assays
- Novus Biologicals Antibodies for FERMT1
- Novus Biologicals proteins and lysates for FERMT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FERMT1: See all 48
- Search antibodies-online for kits
- antibodies-online Proteins for FERMT1: See all 7
- Search antibodies-online for peptides
- GeneTex FERMT1 antibody for FERMT1
- Search GeneTex for Proteins for FERMT1
- ViGene Biosciences adenoviral particle packaged cDNA for FERMT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FERMT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FERMT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FERMT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FERMT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FERMT1 gene
- Search ViGene Biosciences for FERMT1
- Search ViGene Biosciences for FERMT1
Sources for FERMT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
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