FERMT1 Gene

Aliases
for FERMT1 gene

Previous GC identifer: GC20M006004

Summaries
for FERMT1 gene

Genomic Views
for FERMT1 gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011387.8  

SwitchGear Promoter luciferase reporter plasmid: FERMT1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FERMT1

FERMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M006055:  view genomic region     (about GC identifiers)

Proteins
for FERMT1 gene

Explore the universe of human proteins at neXtProt for FERMT1: NX_Q9BQL6

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FERMT1 OriGene Protein Over-expression Lysate: FERMT1 OriGene Custom Protein Services for FERMT1
	GenScript Custom Purified and Recombinant Proteins Services for FERMT1
	Novus Biologicals FERMT1 Proteins Novus Biologicals FERMT1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FERMT1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FERMT1
	Browse R&D Systems for Antibodies
	OriGene Antibodies: FERMT1 OriGene Custom Antibody Services for FERMT1
	GenScript Custom Superior Antibodies Services for FERMT1
	Novus Biologicals FERMT1 Antibodies
	Search for Antibodies for FERMT1 at Abcam
	Uscn Antibodies for FERMT1
	ThermoFisher Antibodies for FERMT1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FERMT1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FERMT1

Protein Domains /
Families
for FERMT1 gene

ProtoNet protein and cluster: Q9BQL6

Function
for FERMT1 gene

miRNA Products:		OriGene 3'-UTR Clone: FERMT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FERMT1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate FERMT1 (see all 9):
		hsa-miR-607 hsa-miR-548o hsa-miR-597 hsa-miR-507 hsa-miR-373* hsa-miR-661 hsa-miR-1323 hsa-miR-24
		SwitchGear 3'UTR luciferase reporter plasmid: FERMT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FERMT1 (see all 7) OriGene shRNA RFP: FERMT1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FERMT1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FERMT1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FERMT1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FERMT1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FERMT1 (NM_017671)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FERMT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FERMT1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FERMT1
		Search LifeMap BioReagents cell lines for FERMT1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FERMT1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Fermt1)

Pathways & Interactions
for FERMT1 gene

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for FERMT1 gene

Transcripts
for FERMT1 gene

Expression
for FERMT1 gene

FERMT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACACAGCA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FERMT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FERMT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FERMT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FERMT1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FERMT1

Orthologs
for FERMT1 gene

Paralogs
for FERMT1 gene

Paralogs for FERMT1 gene

FERMT2²  FERMT3²  

3 SIMAP similar genes for FERMT1 using alignment to 4 protein entries:     FERM1_HUMAN (see all proteins):

DTGCU2    FERMT2    FERMT3

FERMT1 for paralogs           About GeneDecksing

Genomic Variants
for FERMT1 gene

10/1170 NCBI SNPs in FERMT1 are shown (see all 1170)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs2005379361,2	C	--	6011848(+)	TGCTGG/TTGTGT	1	--	ds5001		0	--	--	--	--
rs60538771,2	C,F,A,H,	--	6012117(+)	GGAAAA/CAGTCA	1	--	ds5001		16		NS EA WA CSA NA	2138
rs1996112031,2	C	--	6012388(-)	TGTGAA/CAAAAA	1	--	ut31		0	--	--	--	--
rs61170661,2	C,F,A,H,	--	6012480(+)	AAACAA/TAGTTG	1	--	ut31		14		NS EA NA WA CSA	809
rs110877151,2	C	--	6012720(+)	GTATAA/-TACGG	1	--	ut31		2		NA CSA	4
rs61399081,2	C,H	--	6012813(+)	ACTTCT/CGAGCT	1	--	ut31 ese3		4		NS EA	420
rs1130966261,2		--	6013139(+)	GTGGCA/CGAACA	1	--	ut31		2		CSA WA	120
rs1116450391,2		--	6013302(+)	AGCACC/TGTCTC	1	--	ut31		1		CSA	2
rs81161771,2	H	--	6013395(+)	CCAAAG/ATCCTT	1	--	ut31 ese3		4		NS EA	416
rs412829561,2		--	6013421(+)	GAGTCA/GTACCA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for FERMT1 (6055492 - 6104191 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FERMT1: --
Human Gene Mutation Database (HGMD): FERMT1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FERMT1

DNA2.0 Custom Variant and Variant Library Synthesis for FERMT1

Disorders / Diseases
for FERMT1 gene

10 diseases for FERMT1

1 Novoseek disease relationship for FERMT1 gene    About this table

Publications
for FERMT1 gene

PubMed articles for FERMT1 gene, integrated from 9 sources (see all 58): (articles sorted by number of sources associating them with FERMT1)

Utopia: connect your pdf to the dynamic world of online information

1. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PubMed id 12697302)^{1, 2, 3, 9} Weinstein E.J....Mazzarella R. (2003)
2. Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. (PubMed id 12789646)^{1, 2, 3, 9} Siegel D.H....Epstein E.H. (2003)
3. Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes. (PubMed id 17012746)^{1, 2, 9} Herz C....Has C. (2006)
4. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. (PubMed id 14634021)^{1, 2, 9} Kloeker S....Beckerle M.C. (2004)
5. The structure of the N-terminus of kindlin-1: a domain important for alphaIIbbeta3 integrin activation. (PubMed id 19804783)^{1, 2, 9} Goult B.T.... Critchley D.R. (2009)
6. Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome. (PubMed id 12668616)^{1, 2, 9} Jobard F.... Fischer J. (2003)
7. Kindler syndrome: extension of FERMT1 mutational spectrum and natural history. (PubMed id 21936020)^{1, 2} Has C....Bruckner-Tuderman L. (2011)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
9. Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. (PubMed id 18528435)^{1, 9} Lai-Cheong J.E....McGrath J.A. (2008)
10. Kindlin-1 Is required for RhoGTPase-mediated lamellip odia formation in keratinocytes. (PubMed id 19762715)^{1, 9} Has C....Bruckner-Tuderman L. (2009)

External Searches for FERMT1 gene

Genome Databases showing FERMT1 gene

Other Databases showing FERMT1 gene

Specialized Databases showing FERMT1 gene

Products
for FERMT1 gene