FERD3L Gene
protein-coding GIFtS: 44
GCID: GC07M019150
|
|
Fer3-like (Drosophila)
| |
Aliases
for FERD3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fer3-Like (Drosophila)1 2 | | Nephew Of Atonal 32 3 | | NATO31 2 3 | | Neuronal Twist2 3 | | BHLHa311 | | NTWIST2 3 | | N-TWIST1 2 | | Fer3-Like Protein2 | | Basic Helix-Loop-Helix Protein N-Twist2 3 | | BHLHA313 | | Class A Basic Helix-Loop-Helix Protein 312 3 | | |
Export aliases for FERD3L gene to outside databasesPrevious GC identifers: GC07M018828 GC07M018928 GC07M018957 |
Summaries
for FERD3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FER3L_HUMAN, Q96RJ6Function: Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA bindingrequires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins(By similarity)
|
Genomic Views
for FERD3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FERD3L gene promoter:
AML1a p53 ATF-2 HSF1 (long) POU3F2 E47 PPAR-alpha HSF1short c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for FERD3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FERD3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p21.1 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p21.3FERD3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M019150: view genomic region
(about GC identifiers)
Start:
|
19,184,405 bp from pter |
End:
|
19,185,044 bp from pter |
Size:
|
640 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 19,235,856-19,236,495 |
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Proteins
for FERD3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FER3L_HUMAN, Q96RJ6 (See
protein sequence)Recommended Name: Fer3-like protein Size: 166 amino acids; 19017 Da
Subunit: Heterodimer with TCF3/E12. Interacts with the bHLH domain of TCF3/E12 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q495K0Explore the universe of human proteins at neXtProt for FERD3L: NX_Q96RJ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RJ6
FERD3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_690862.1
ENSEMBL proteins: ENSP00000275461
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
FERD3L for ontologies About GeneDecksing
FERD3L Antibody Products:
Assay Products for FERD3L: |
Protein
Domains /
Families
for FERD3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FERD3L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96RJ6ProtoNet protein and cluster: Q96RJ6 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: FER3L_HUMAN, Q96RJ6Similarity: Contains 1 bHLH (basic helix-loop-helix) domain |
Function
for FERD3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FER3L_HUMAN, Q96RJ6Function: Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA bindingrequires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins(By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FERD3L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FERD3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FERD3L (NM_152898) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FERD3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FERD3L |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- |
FERD3L for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ferd3l):
FERD3L for phenotypes About GeneDecksing
|
Pathways & Interactions
for FERD3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FERD3L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FERD3L (Q96RJ63 ENSP000002754614) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
ISS | -- |
FERD3L for ontologies About GeneDecksing
|
Drugs & Compounds
for FERD3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FERD3L
Search CenterWatch for drugs/clinical trials and news about FERD3L / FER3L
|
Transcripts
for FERD3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FERD3L gene: NM_152898.2 Unigene Cluster for FERD3L: Fer3-like (Drosophila) Hs.592168 Unigene Representative Sequence: AF5171221 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000275461(uc003suo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FERD3L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FERD3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FERD3L (NM_152898) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FERD3L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FERD3L |
Additional cDNA sequence: AF517122.1 BC069147.1 BC101135.1 BC101136.1 BC101137.1 BC101138.2 1 DOTS entry: DT.100000413 5 AceView cDNA sequences: BC069147 BI834521 BC043576 NM_152898 AF517122
GeneLoc Exon Structure
|
Expression
for FERD3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FERD3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCGAGCTCT
About this image
See FERD3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FERD3L
SOURCE GeneReport for Unigene cluster: Hs.592168
SABiosciences Custom PCR Arrays for FERD3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FERD3L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FERD3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FERD3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FERD3L |
Orthologs
for FERD3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FERD3L gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FERD3L1 |
Fer3-like (Drosophila) |
71.27(n)
69.08(a) |
|
428429 XM_425989.1 XP_425989.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FERD3L6 |
-- |
73(a) |
1 ↔ 1 |
6(28678177-28678431) |
zebrafish
(Danio rerio) |
Actinopterygii |
ferd3l6 |
Fer3-like (Drosophila) |
72(a) |
1 ↔ 1 |
19(2463510-2463753) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Fer36 |
48 related 3 |
30(a) |
1 ↔ 1 |
3R(7519132-7519999) |
worm
(Caenorhabditis elegans) |
Secernentea |
hlh-136 |
Helix-loop-helix protein 13 |
26(a) |
1 ↔ 1 |
X(4249225-4250740) |
ENSEMBL Gene Tree for FERD3L (if available)
TreeFam Gene Tree for FERD3L (if available) |
Paralogs
for FERD3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FERD3L gene
- NEUROG32 NEUROD22 NEUROD12 NEUROD62 ATOH12 NEUROG22 BHLHA152 PTF1A2
- ATOH72 NEUROG12 NEUROD42
6 SIMAP similar genes for FERD3L using alignment to 1 protein entry: FER3L_HUMAN:PTF1A ATOH1 NEUROD4 NHLH1 NEUROD6 NEUROD2
FERD3L for paralogs About GeneDecksing
|
Genomic Variants
for FERD3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FERD3L (19184405 - 19185044 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FERD3L
1 CNV: 0101 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FERD3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FERD3L for disorders About GeneDecksing
4  diseases for FERD3L: About MalaCardssaethre-chotzen syndrome learning disability neuronitis brachydactyly
1 disease from the University of Copenhagen DISEASES database for FERD3L:Saethre-Chotzen syndrome Export disorders for FERD3L gene to outside databases
|
Publications
for FERD3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FERD3L gene integrated from 9 sources:
(articles sorted by number of sources associating them with FERD3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. (PubMed id 12217327)1, 2, 3 Verzi M.P.... Black B.L. (2002)
- Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse. (PubMed id 11472856)1, 2, 3 Segev E.... Ben-Arie N. (2001)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FERD3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FERD3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FERD3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FERD3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FERD3L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FERD3L gene:
Search GeneIP for patents involving FERD3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FERD3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FERD3L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FERD3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FERD3L | | | OriGene Protein Over-expression Lysate for FERD3L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FERD3L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FERD3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FERD3L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FERD3L | | OriGene Custom Protein Services for FERD3L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FERD3L | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FERD3L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FERD3L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FERD3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FERD3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FERD3L |
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| |  |  |  |  | | | | |
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 | | | FERD3L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FERD3L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FERD3L |
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