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Aliases for FERD3L Gene

Aliases for FERD3L Gene

  • Fer3-Like BHLH Transcription Factor 2 3
  • Class A Basic Helix-Loop-Helix Protein 31 3 4
  • Basic Helix-Loop-Helix Protein N-Twist 3 4
  • Nephew Of Atonal 3 3 4
  • Neuronal Twist 3 4
  • BHLHa31 3 4
  • NTWIST 3 4
  • NATO3 3 4
  • Fer3-Like (Drosophila) 2
  • Fer3-Like Protein 3
  • N-TWIST 3

External Ids for FERD3L Gene

Summaries for FERD3L Gene

GeneCards Summary for FERD3L Gene

FERD3L (Fer3-Like BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with FERD3L include acrocephalosyndactylia and colorectal cancer. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is PTF1A.

UniProtKB/Swiss-Prot for FERD3L Gene

  • Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FERD3L Gene

Genomics for FERD3L Gene

Genomic Location for FERD3L Gene

Start:
19,144,782 bp from pter
End:
19,145,421 bp from pter
Size:
640 bases
Orientation:
Minus strand

Genomic View for FERD3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FERD3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FERD3L Gene

Regulatory Elements for FERD3L Gene

Proteins for FERD3L Gene

  • Protein details for FERD3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RJ6-FER3L_HUMAN
    Recommended name:
    Fer3-like protein
    Protein Accession:
    Q96RJ6
    Secondary Accessions:
    • Q495K0

    Protein attributes for FERD3L Gene

    Size:
    166 amino acids
    Molecular mass:
    19017 Da
    Quaternary structure:
    • Heterodimer with TCF3/E12. Interacts with the bHLH domain of TCF3/E12 (By similarity).

neXtProt entry for FERD3L Gene

Proteomics data for FERD3L Gene at MOPED

Post-translational modifications for FERD3L Gene

No Post-translational modifications

Other Protein References for FERD3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FERD3L Gene

Domains for FERD3L Gene

Gene Families for FERD3L Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for FERD3L Gene

UniProtKB/Swiss-Prot:

FER3L_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q96RJ6
genes like me logo Genes that share domains with FERD3L: view

Function for FERD3L Gene

Molecular function for FERD3L Gene

UniProtKB/Swiss-Prot Function: Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).

Gene Ontology (GO) - Molecular Function for FERD3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with FERD3L: view

Phenotypes for FERD3L Gene

genes like me logo Genes that share phenotypes with FERD3L: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FERD3L Gene

Localization for FERD3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FERD3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FERD3L Gene COMPARTMENTS Subcellular localization image for FERD3L gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FERD3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with FERD3L: view

Pathways for FERD3L Gene

SuperPathways for FERD3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for FERD3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0033504 floor plate development IEA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:0048468 cell development IEA --
GO:0050767 regulation of neurogenesis IEA --
genes like me logo Genes that share ontologies with FERD3L: view

No data available for Pathways by source for FERD3L Gene

Transcripts for FERD3L Gene

mRNA/cDNA for FERD3L Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FERD3L Gene

No ASD Table

Relevant External Links for FERD3L Gene

GeneLoc Exon Structure for
FERD3L
ECgene alternative splicing isoforms for
FERD3L

Expression for FERD3L Gene

mRNA expression in normal human tissues for FERD3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FERD3L Gene

This gene is overexpressed in Brain - Hypothalamus (5.6), Brain - Substantia nigra (5.1), and Brain - Frontal Cortex (BA9) (4.4).

SOURCE GeneReport for Unigene cluster for FERD3L Gene Hs.592168

genes like me logo Genes that share expressions with FERD3L: view

Orthologs for FERD3L Gene

This gene was present in the common ancestor of animals.

Orthologs for FERD3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FERD3L 36
  • 99.4 (n)
  • 100 (a)
FERD3L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FERD3L 36
  • 84.37 (n)
  • 81.87 (a)
FERD3L 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FERD3L 36
  • 83.73 (n)
  • 80.12 (a)
FERD3L 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ferd3l 36
  • 78.59 (n)
  • 78.79 (a)
Ferd3l 16
Ferd3l 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FERD3L 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FERD3L 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ferd3l 36
  • 78.12 (n)
  • 77.3 (a)
chicken
(Gallus gallus)
Aves FERD3L 36
  • 69.91 (n)
  • 68.18 (a)
FERD3L 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FERD3L 37
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ferd3l 37
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fer3 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-13 37
  • 26 (a)
OneToMany
Species with no ortholog for FERD3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FERD3L Gene

ENSEMBL:
Gene Tree for FERD3L (if available)
TreeFam:
Gene Tree for FERD3L (if available)

Paralogs for FERD3L Gene

Paralogs for FERD3L Gene

Selected SIMAP similar genes for FERD3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FERD3L: view

Variants for FERD3L Gene

Sequence variations from dbSNP and Humsavar for FERD3L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10228726 -- 19,147,176(+) GGAAG(A/G)TGTTA upstream-variant-2KB
rs10257807 -- 19,146,842(+) ACATC(C/T)CGGTT upstream-variant-2KB
rs12700019 -- 19,147,263(+) AATAG(C/G)ATTGT upstream-variant-2KB
rs73325572 -- 19,146,973(+) CTCAA(C/T)TCATT upstream-variant-2KB
rs75251182 -- 19,146,789(+) AGATA(A/G)TTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FERD3L Gene

Variant ID Type Subtype PubMed ID
nsv482940 CNV Gain 15286789

Relevant External Links for FERD3L Gene

HapMap Linkage Disequilibrium report
FERD3L

Disorders for FERD3L Gene

(1) University of Copenhagen DISEASES for FERD3L Gene

Relevant External Links for FERD3L

Genetic Association Database (GAD)
FERD3L
genes like me logo Genes that share disorders with FERD3L: view

No data available for UniProtKB/Swiss-Prot for FERD3L Gene

Publications for FERD3L Gene

  1. Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse. (PMID: 11472856) Segev E. … Ben-Arie N. (Mech. Dev. 2001) 2 3 4
  2. N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. (PMID: 12217327) Verzi M.P. … Black B.L. (Dev. Biol. 2002) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FERD3L Gene

  • antibodies-online proteins for FERD3L
  • antibodies-online antibodies for FERD3L
  • antibodies-online kits for FERD3L

Sources for FERD3L Gene

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