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Aliases for FER1L6 Gene

Aliases for FER1L6 Gene

  • Fer-1 Like Family Member 6 2 3 5
  • C8ORFK23 3 4
  • Fer-1-Like 6 (C. Elegans) 2
  • Fer-1-Like Protein 6 3
  • Fer-1-Like 6 3

External Ids for FER1L6 Gene

Previous GeneCards Identifiers for FER1L6 Gene

  • GC08P124935
  • GC08P120280
  • GC08P124864

Summaries for FER1L6 Gene

GeneCards Summary for FER1L6 Gene

FER1L6 (Fer-1 Like Family Member 6) is a Protein Coding gene. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is OTOF.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L6 Gene

Genomics for FER1L6 Gene

Regulatory Elements for FER1L6 Gene

Enhancers for FER1L6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G123876 1.5 FANTOM5 Ensembl ENCODE 18.6 +26.3 26318 3.4 HDGF ATF1 PKNOX1 ARNT SIN3A ZNF143 FOS REST MIER2 ZNF592 FER1L6 ENSG00000253607 GC08P123918
GH08G123911 1 Ensembl ENCODE 6.5 +60.1 60093 1.9 CTCF PKNOX1 NFIB ZMYM3 CEBPG FEZF1 RAD21 ZKSCAN1 GATA3 EGR1 ENSG00000254249 FER1L6-AS1 FER1L6 IMPDH1P6 ZHX1 GC08P123918
GH08G123920 1.3 Ensembl ENCODE 4.7 +69.7 69737 3.1 PKNOX1 CREB3L1 ARNT SIN3A ZNF766 ZNF143 FOS ZHX2 JUNB REST FAM91A1 FER1L6 GC08P123918 ENSG00000254000
GH08G122862 1.1 Ensembl ENCODE dbSUPER 4.4 -989.2 -989153 1.6 ZNF316 MAFG CREB1 NFE2 EMSY ATF2 FER1L6 GC08P122905 ENSG00000253372
GH08G123904 0.4 FANTOM5 5.1 +52.7 52709 0.3 ZNF366 ZNF512 FER1L6 GC08P123918
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FER1L6 on UCSC Golden Path with GeneCards custom track

Genomic Location for FER1L6 Gene

123,851,987 bp from pter
124,120,061 bp from pter
268,075 bases
Plus strand

Genomic View for FER1L6 Gene

Genes around FER1L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER1L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER1L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L6 Gene

Proteins for FER1L6 Gene

  • Protein details for FER1L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fer-1-like protein 6
    Protein Accession:

    Protein attributes for FER1L6 Gene

    1857 amino acids
    Molecular mass:
    209308 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FER1L6 Gene

Post-translational modifications for FER1L6 Gene

  • Ubiquitination at Lys578
  • Modification sites at PhosphoSitePlus

Other Protein References for FER1L6 Gene

No data available for DME Specific Peptides for FER1L6 Gene

Domains & Families for FER1L6 Gene

Gene Families for FER1L6 Gene

Protein Domains for FER1L6 Gene

Suggested Antigen Peptide Sequences for FER1L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ferlin family.
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L6: view

Function for FER1L6 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FER1L6 Gene

Localization for FER1L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L6 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FER1L6 gene
Compartment Confidence
cytosol 3
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for FER1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FER1L6: view

Pathways & Interactions for FER1L6 Gene

SuperPathways for FER1L6 Gene

No Data Available

Interacting Proteins for FER1L6 Gene

Gene Ontology (GO) - Biological Process for FER1L6 Gene


No data available for Pathways by source and SIGNOR curated interactions for FER1L6 Gene

Drugs & Compounds for FER1L6 Gene

No Compound Related Data Available

Transcripts for FER1L6 Gene

mRNA/cDNA for FER1L6 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FER1L6 Gene

Fer-1-like 6 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L6 Gene

No ASD Table

Relevant External Links for FER1L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FER1L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FER1L6 Gene

mRNA differential expression in normal tissues according to GTEx for FER1L6 Gene

This gene is overexpressed in Stomach (x17.3), Testis (x9.5), Colon - Transverse (x8.2), and Small Intestine - Terminal Ileum (x4.7).

Protein differential expression in normal tissues from HIPED for FER1L6 Gene

This gene is overexpressed in Nasal epithelium (50.5) and Stomach (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FER1L6 Gene

Protein tissue co-expression partners for FER1L6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FER1L6 Gene:


SOURCE GeneReport for Unigene cluster for FER1L6 Gene:


Evidence on tissue expression from TISSUES for FER1L6 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with FER1L6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FER1L6 Gene

Orthologs for FER1L6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FER1L6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FER1L6 34 35
  • 99.21 (n)
(Canis familiaris)
Mammalia FER1L6 34 35
  • 89.31 (n)
(Bos Taurus)
Mammalia FER1L6 34 35
  • 88.74 (n)
(Rattus norvegicus)
Mammalia Fer1l6 34
  • 85.93 (n)
(Mus musculus)
Mammalia Fer1l6 34 16 35
  • 85.39 (n)
(Monodelphis domestica)
Mammalia FER1L6 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia FER1L6 35
  • 77 (a)
(Gallus gallus)
Aves FER1L6 34 35
  • 72.21 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 81 (a)
-- 35
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fer1l6 34
  • 68.93 (n)
(Danio rerio)
Actinopterygii fer1l6 34
  • 62.94 (n)
FER1L6 35
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta mfr 34 35
  • 44.44 (n)
(Caenorhabditis elegans)
Secernentea fer-1 35
  • 20 (a)
ferl-1 35
  • 15 (a)
Species where no ortholog for FER1L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FER1L6 Gene

Gene Tree for FER1L6 (if available)
Gene Tree for FER1L6 (if available)

Paralogs for FER1L6 Gene

Paralogs for FER1L6 Gene

(2) SIMAP similar genes for FER1L6 Gene using alignment to 1 proteins: Pseudogenes for FER1L6 Gene

genes like me logo Genes that share paralogs with FER1L6: view

Variants for FER1L6 Gene

Sequence variations from dbSNP and Humsavar for FER1L6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000014015 -- 124,055,176(+) GTTCA(A/C/T)GCCTG intron-variant
rs1000025475 -- 123,870,874(+) CTGTA(C/T)TAAAA intron-variant
rs1000027589 -- 123,918,943(+) GGGCT(A/C)TCAGT intron-variant
rs1000036697 -- 124,001,687(+) TGGGA(C/G)AAAGA intron-variant
rs1000044054 -- 124,006,360(+) ATGCT(G/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FER1L6 Gene

Variant ID Type Subtype PubMed ID
dgv12305n54 CNV loss 21841781
dgv7308n100 CNV loss 25217958
esv1213669 CNV insertion 17803354
esv2310236 CNV deletion 18987734
esv23245 CNV loss 19812545
esv3306706 CNV mobile element insertion 20981092
esv3309379 CNV mobile element insertion 20981092
esv3344858 CNV insertion 20981092
esv3359343 CNV insertion 20981092
esv3618674 CNV gain 21293372
esv3618675 CNV loss 21293372
esv3618679 CNV loss 21293372
esv3618680 CNV loss 21293372
nsv1020971 CNV gain 25217958
nsv1023183 CNV loss 25217958
nsv1124375 CNV deletion 24896259
nsv395998 CNV insertion 16902084
nsv435876 CNV deletion 17901297
nsv510173 OTHER sequence alteration 20534489
nsv510985 OTHER complex 20534489
nsv612143 CNV loss 21841781
nsv612144 CNV loss 21841781
nsv6374 CNV deletion 18451855
nsv6375 CNV deletion 18451855
nsv820240 CNV loss 19587683
nsv831451 CNV gain+loss 17160897
nsv831452 CNV gain 17160897
nsv958472 CNV deletion 24416366

Variation tolerance for FER1L6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FER1L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FER1L6 Gene

Disorders for FER1L6 Gene

Relevant External Links for FER1L6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FER1L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FER1L6 Gene

Publications for FER1L6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PMID: 20200978) Ichikawa S. … Econs M.J. (J. Bone Miner. Res. 2010) 3 64
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 46 64
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64

Products for FER1L6 Gene

Sources for FER1L6 Gene

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