FER1L6 Gene
protein-coding GIFtS: 36
GCID: GC08P124864
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fer-1-like 6 (C. elegans)
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Aliases
for FER1L6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fer-1-Like 6 (C. Elegans)1 2 | | C8ORFK231 2 | | Fer-1-Like Protein 62 | | C8orfK233 |
Export aliases for FER1L6 gene to outside databasesPrevious GC identifers: GC08P124935 GC08P120280 |
Summaries
for FER1L6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FER1L6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FER1L6 gene promoter:
GATA-3 Nkx5-1 GATA-2 GATA-1 Meis-1b FOXJ2 (long isoform) FOXJ2 Meis-1a Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FER1L6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FER1L6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.1 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13FER1L6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P124864: view genomic region
(about GC identifiers)
Start:
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124,864,227 bp from pter |
End:
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125,132,302 bp from pter |
Size:
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268,076 bases |
Orientation:
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plus strand |
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Proteins
for FER1L6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FR1L6_HUMAN, Q2WGJ9 (See
protein sequence)Recommended Name: Fer-1-like protein 6 Size: 1857 amino acids; 209308 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for FER1L6: NX_Q2WGJ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2WGJ9
FER1L6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034201.2
ENSEMBL proteins: ENSP00000428280 ENSP00000381982
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
FER1L6 for ontologies About GeneDecksing
FER1L6 Antibody Products:
Assay Products for FER1L6: |
Protein
Domains /
Families
for FER1L6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FER1L6 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2WGJ9ProtoNet protein and cluster: Q2WGJ9 3 Blocks protein families: IPB000008 C2 domain IPB012561 FerB IPB012968 FerI
UniProtKB/Swiss-Prot: FR1L6_HUMAN, Q2WGJ9Similarity: Belongs to the ferlin familySimilarity: Contains 6 C2 domains |
Function
for FER1L6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FER1L6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FER1L6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FER1L6 (NM_001039112) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FER1L6 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FER1L6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER1L6 |
|
Pathways & Interactions
for FER1L6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FER1L6
|
Drugs & Compounds
for FER1L6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FER1L6
Search CenterWatch for drugs/clinical trials and news about FER1L6 / FR1L6
|
Transcripts
for FER1L6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FER1L6 gene: NM_001039112.2 Unigene Cluster for FER1L6: Fer-1-like 6 (C. elegans) Hs.632058 [show with all ESTs]Unigene Representative Sequence: AB1966332 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522917(uc003yqw.3) ENST00000399018
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FER1L6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FER1L6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FER1L6 (NM_001039112) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FER1L6 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FER1L6 |
Additional cDNA sequence: AB196633.1 1 DOTS entry: DT.95137898
GeneLoc Exon Structure
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Expression
for FER1L6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FER1L6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAATCAACA
About this image
See FER1L6 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.632058
SABiosciences Custom PCR Arrays for FER1L6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FER1L6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FER1L6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FER1L6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FER1L6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER1L6 |
Orthologs
for FER1L6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FER1L6 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for FER1L6 (if available)
TreeFam Gene Tree for FER1L6 (if available) |
Paralogs
for FER1L6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FER1L6 gene
- OTOF2 MYOF2 DYSF2
2 SIMAP similar genes for FER1L6 using alignment to 1 protein entry: FR1L6_HUMAN:OTOF FER1L4
FER1L6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FER1L6
PGOHUM00000250543
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Genomic Variants
for FER1L6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FER1L6 (124864227 - 125114227 bp, first 250kb of FER1L6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FER1L6
3 CNVs: 23098 65256 59453 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FER1L6 |
|
Disorders
/ Diseases
for FER1L6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FER1L6 for disorders About GeneDecksing
3  diseases for FER1L6: About MalaCardspremature ovarian failure amenorrhea malaria
1 disease from the University of Copenhagen DISEASES database for FER1L6:Premature ovarian failure Human Genome Epidemiology (HuGE) Navigator: FER1L6 (2 documents)
Export disorders for FER1L6 gene to outside databases
|
Publications
for FER1L6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FER1L6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FER1L6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for FER1L6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FER1L6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FER1L6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FER1L6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FER1L6 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FER1L6 gene:
Search GeneIP for patents involving FER1L6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FER1L6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FER1L6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FER1L6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FER1L6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FER1L6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FER1L6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FER1L6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FER1L6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FER1L6 | | OriGene Custom Protein Services for FER1L6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FER1L6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FER1L6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FER1L6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FER1L6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FER1L6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FER1L6 |
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| | | | Search Tocris compounds for FER1L6 |
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 | | | FER1L6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER1L6 |
|  |  |  | | | | Search ThermoFisher Antibodies for FER1L6 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FER1L6 |
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