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Aliases for FER1L6 Gene

Aliases for FER1L6 Gene

  • Fer-1 Like Family Member 6 2 3
  • Fer-1-Like Family Member 6 3 5
  • C8ORFK23 3 4
  • Fer-1-Like 6 (C. Elegans) 2
  • Fer-1-Like 6 3

External Ids for FER1L6 Gene

Previous GeneCards Identifiers for FER1L6 Gene

  • GC08P124935
  • GC08P120280
  • GC08P124864

Summaries for FER1L6 Gene

GeneCards Summary for FER1L6 Gene

FER1L6 (Fer-1 Like Family Member 6) is a Protein Coding gene. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is FER1L5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L6 Gene

Genomics for FER1L6 Gene

Regulatory Elements for FER1L6 Gene

Enhancers for FER1L6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FER1L6 on UCSC Golden Path with GeneCards custom track

Genomic Location for FER1L6 Gene

123,851,987 bp from pter
124,120,061 bp from pter
268,075 bases
Plus strand

Genomic View for FER1L6 Gene

Genes around FER1L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER1L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER1L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L6 Gene

Proteins for FER1L6 Gene

  • Protein details for FER1L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fer-1-like protein 6
    Protein Accession:

    Protein attributes for FER1L6 Gene

    1857 amino acids
    Molecular mass:
    209308 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FER1L6 Gene

Proteomics data for FER1L6 Gene at MOPED

Post-translational modifications for FER1L6 Gene

  • Ubiquitination at Lys 578
  • Modification sites at PhosphoSitePlus

Other Protein References for FER1L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FER1L6 Gene

Domains & Families for FER1L6 Gene

Gene Families for FER1L6 Gene

Protein Domains for FER1L6 Gene

Suggested Antigen Peptide Sequences for FER1L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 C2 domains.
  • Belongs to the ferlin family.
  • Contains 6 C2 domains.
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L6: view

Function for FER1L6 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FER1L6 Gene

Localization for FER1L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L6 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FER1L6 Gene COMPARTMENTS Subcellular localization image for FER1L6 gene
Compartment Confidence
cytosol 3
endosome 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FER1L6 Gene

Pathways & Interactions for FER1L6 Gene

SuperPathways for FER1L6 Gene

No Data Available

Interacting Proteins for FER1L6 Gene

Gene Ontology (GO) - Biological Process for FER1L6 Gene


No data available for Pathways by source and SIGNOR curated interactions for FER1L6 Gene

Drugs & Compounds for FER1L6 Gene

No Compound Related Data Available

Transcripts for FER1L6 Gene

mRNA/cDNA for FER1L6 Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FER1L6 Gene

Fer-1-like 6 (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L6 Gene

No ASD Table

Relevant External Links for FER1L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FER1L6 Gene

mRNA expression in normal human tissues for FER1L6 Gene

mRNA differential expression in normal tissues according to GTEx for FER1L6 Gene

This gene is overexpressed in Stomach (x17.3), Testis (x9.5), Colon - Transverse (x8.2), and Small Intestine - Terminal Ileum (x4.7).

Protein differential expression in normal tissues from HIPED for FER1L6 Gene

This gene is overexpressed in Nasal epithelium (50.5) and Stomach (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FER1L6 Gene

SOURCE GeneReport for Unigene cluster for FER1L6 Gene Hs.632058

genes like me logo Genes that share expression patterns with FER1L6: view

Protein tissue co-expression partners for FER1L6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FER1L6 Gene

Orthologs for FER1L6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FER1L6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FER1L6 35
  • 88.74 (n)
  • 89.92 (a)
FER1L6 36
  • 86 (a)
(Canis familiaris)
Mammalia FER1L6 35
  • 89.31 (n)
  • 90.3 (a)
FER1L6 36
  • 90 (a)
(Mus musculus)
Mammalia Fer1l6 35
  • 85.39 (n)
  • 88.51 (a)
Fer1l6 16
Fer1l6 36
  • 88 (a)
(Pan troglodytes)
Mammalia FER1L6 35
  • 99.21 (n)
  • 99.08 (a)
FER1L6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fer1l6 35
  • 85.93 (n)
  • 88.45 (a)
(Monodelphis domestica)
Mammalia FER1L6 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia FER1L6 36
  • 77 (a)
(Gallus gallus)
Aves FER1L6 35
  • 72.21 (n)
  • 74.77 (a)
FER1L6 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
-- 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fer1l6 35
  • 68.93 (n)
  • 71.42 (a)
(Danio rerio)
Actinopterygii fer1l6 35
  • 62.94 (n)
  • 62.51 (a)
FER1L6 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta mfr 35
  • 44.44 (n)
  • 31.84 (a)
mfr 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea fer-1 36
  • 20 (a)
ferl-1 36
  • 15 (a)
Species with no ortholog for FER1L6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FER1L6 Gene

Gene Tree for FER1L6 (if available)
Gene Tree for FER1L6 (if available)

Paralogs for FER1L6 Gene

Paralogs for FER1L6 Gene

(2) SIMAP similar genes for FER1L6 Gene using alignment to 1 proteins: Pseudogenes for FER1L6 Gene

genes like me logo Genes that share paralogs with FER1L6: view

Variants for FER1L6 Gene

Sequence variations from dbSNP and Humsavar for FER1L6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_039558 -
rs2116360 -- 123,871,693(+) catag(A/C)ttccc intron-variant
rs2163533 -- 123,871,918(+) aaacc(C/T)atatg intron-variant
rs2385522 -- 123,853,822(+) ACATC(A/G)CGGCC intron-variant
rs7829766 -- 123,905,495(+) tttgg(A/G)ttgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FER1L6 Gene

Variant ID Type Subtype PubMed ID
nsv831451 CNV Gain+Loss 17160897
nsv6374 CNV Loss 18451855
nsv395998 CNV Insertion 16902084
esv1213669 CNV Insertion 17803354
nsv510173 CNV Loss 20534489
nsv820240 CNV Loss 19587683
esv2310236 CNV Deletion 18987734
nsv435876 CNV Deletion 17901297
nsv6375 CNV Loss 18451855
esv270982 CNV Insertion 20981092
esv273651 CNV Insertion 20981092
nsv510985 CNV Complex 20534489
nsv831452 CNV Gain 17160897
esv23245 CNV Loss 19812545

Variation tolerance for FER1L6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FER1L6 Gene

Disorders for FER1L6 Gene

Relevant External Links for FER1L6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FER1L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FER1L6 Gene

Publications for FER1L6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PMID: 20200978) Ichikawa S. … Econs M.J. (J. Bone Miner. Res. 2010) 3

Products for FER1L6 Gene

Sources for FER1L6 Gene