Aliases for FER1L5 Gene
External Ids for FER1L5 Gene
- HGNC: 19044
- Entrez Gene: 90342
- Ensembl: ENSG00000249715
- UniProtKB: A0AVI2
Previous GeneCards Identifiers for FER1L5 Gene
- GC08U900646
- GC02P096673
- GC02P097308
Summaries for FER1L5 Gene
GeneCards Summary for FER1L5 Gene
FER1L5 (Fer-1 Like Family Member 5) is a Protein Coding gene. An important paralog of this gene is DYSF.
UniProtKB/Swiss-Prot for FER1L5 Gene
-
Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L5 Gene
Genomics for FER1L5 Gene
Regulatory Elements for FER1L5 Gene
Enhancers for FER1L5 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G096615 | 1 | Ensembl ENCODE | 13 | -24.8 | -24806 | 3.8 | ELF3 KLF1 FOXA2 SAP130 TAF1 KLF17 MAX CEBPG RAD21 RARA | CNNM3 ARID5A FER1L5 KANSL3 LOC105373496 CNNM4 LMAN2L ITPRIPL1 SNRNP200 GC02P096595 |
| GH02G096636 | 1.2 | ENCODE | 0.4 | -5.0 | -5004 | 2.8 | MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D | ANKRD36B STARD7-AS1 CIAO1 FER1L5 GC02P096595 |
| GH02G096600 | 1 | ENCODE | 0.3 | -40.8 | -40772 | 2.3 | PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 PPARG | LMAN2L CIAO1 GC02P096595 FER1L5 |
| GH02G096631 | 0.6 | ENCODE | 0.4 | -10.4 | -10395 | 1.8 | ATF3 CEBPA HLF SCRT2 CEBPG FOS | CIAO1 FER1L5 GC02P096595 |
| GH02G096608 | 0.7 | ENCODE | 0.3 | -33.9 | -33914 | 1.4 | TFAP4 ESRRA SAP130 RAD21 RARA ZNF316 NR2F6 NFE2 MAFK NFE2L2 | ARID5A LOC105373496 CNNM3 KANSL3 GC02P096595 FER1L5 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FER1L5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FER1L5 Gene
- Chromosome:
- 2
- Start:
- 96,642,711 bp from pter
- End:
- 96,706,220 bp from pter
- Size:
- 63,510 bases
- Orientation:
- Plus strand
Genomic View for FER1L5 Gene
Genes around FER1L5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by Ensembl
- 2q11.2 by Entrez Gene
- 2q11.2 by HGNC
FER1L5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FER1L5 Gene
Proteins for FER1L5 Gene
-
Protein details for FER1L5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0AVI2-FR1L5_HUMAN
- Recommended name:
- Fer-1-like protein 5
- Protein Accession:
- A0AVI2
- Q17RH2
- Q6ZU24
Protein attributes for FER1L5 Gene
- Size:
- 2093 amino acids
- Molecular mass:
- 241963 Da
- Quaternary structure:
-
- Interacts (via second C2 domain) with EHD1 and EHD2.
Protein Expression for FER1L5 Gene
Post-translational modifications for FER1L5 Gene
Other Protein References for FER1L5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FER1L5
- Search GeneTex for Antibodies for FER1L5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FER1L5
- Origene Custom Protein Services for FER1L5
- Search GeneTex for Proteins for FER1L5
Assay Products
No data available for DME Specific Peptides for FER1L5 Gene
Domains & Families for FER1L5 Gene
Gene Families for FER1L5 Gene
- HGNC:
Protein Domains for FER1L5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FER1L5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A0AVI2- Family:
-
- Belongs to the ferlin family.
Function for FER1L5 Gene
Molecular function for FER1L5 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.
Phenotypes for FER1L5 Gene
- GenomeRNAi human phenotypes for FER1L5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FER1L5 gene
- Search ViGene Biosciences for FER1L5
CRISPR Products
-
OriGene CRISPR knockouts for FER1L5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FER1L5
miRNA Products
- Search ViGene Biosciences for FER1L5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FER1L5
- Browse OriGene Inhibitory RNA Products For FER1L5
- Search ViGene Biosciences for FER1L5
Clone Products
-
OriGene ORF clones in human for FER1L5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
Horizon Cell Lines for FER1L5
-
ViGene Biosciences adenoviral particle packaged cDNA for FER1L5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FER1L5 gene
- Search ViGene Biosciences for FER1L5
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FER1L5 Gene
Localization for FER1L5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FER1L5 Gene
- Cell membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity). {ECO:0000250}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS for FER1L5 Gene
Pathways & Interactions for FER1L5 Gene
No Data Available
Interacting Proteins for FER1L5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007520 | myoblast fusion | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FER1L5 Gene
Transcripts for FER1L5 Gene
mRNA/cDNA for FER1L5 Gene
- (22) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (3) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FER1L5 Gene
- Fer-1-like 5 (C. elegans):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FER1L5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FER1L5
miRNA Products
- Search ViGene Biosciences for FER1L5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FER1L5
- Browse OriGene Inhibitory RNA Products For FER1L5
- Search ViGene Biosciences for FER1L5
Clone Products
-
OriGene ORF clones in human for FER1L5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for FER1L5 Gene
mRNA differential expression in normal tissues according to GTEx for FER1L5 Gene
This gene is overexpressed in Testis (x23.2) and Pancreas (x5.8).
This gene is overexpressed in Rectum (14.8), Heart (8.4), Stomach (7.5), and Urinary Bladder (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FER1L5 Gene
NURSA nuclear receptor signaling pathways regulating expression of FER1L5 Gene:
FER1L5SOURCE GeneReport for Unigene cluster for FER1L5 Gene:
Hs.534025Primer Products
-
OriGene qPCR primer pairs for FER1L5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FER1L5 Gene
Orthologs for FER1L5 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FER1L5 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FER1L5 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FER1L5 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fer1l5 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fer1l5 34 |
|
- Species where no ortholog for FER1L5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FER1L5 Gene
(3) SIMAP similar genes for FER1L5 Gene using alignment to 3 proteins:
Variants for FER1L5 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011491 | -- | 96,653,092(+) | GGTGC(A/C)TGTAA | intron-variant | |
| rs1000022031 | -- | 96,696,603(+) | ATCTT(-/A)AAAAA | intron-variant | |
| rs1000053354 | -- | 96,696,797(+) | CTACT(A/C)TGGAG | intron-variant | |
| rs1000075546 | -- | 96,703,997(+) | TTTTA(A/G)TAGAG | intron-variant | |
| rs1000101200 | -- | 96,670,501(+) | GGCAA(A/G)GTGCG | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv607e201 | CNV | deletion | 23290073 |
| esv2720413 | CNV | deletion | 23290073 |
| esv3425717 | CNV | duplication | 20981092 |
| esv3591690 | CNV | gain | 21293372 |
| esv5003 | OTHER | complex | 18987735 |
| nsv1135873 | CNV | deletion | 24896259 |
| nsv469775 | CNV | loss | 16826518 |
| nsv526313 | CNV | loss | 19592680 |
| nsv834306 | CNV | loss | 17160897 |
| nsv834307 | CNV | loss | 17160897 |
Relevant External Links for FER1L5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FER1L5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FER1L5 Gene
Disorders for FER1L5 Gene
Relevant External Links for FER1L5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FER1L5
No disorders were found for FER1L5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FER1L5 Gene
Publications for FER1L5 Gene
- Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for FER1L5 Gene
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- Custom Antibody ServicesOriGene Antibodies for FER1L5
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- OriGene qPCR primer pairs for FER1L5
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- Novus Biologicals
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- VectorBuilder custom plasmid, inducible vectors for FER1L5
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FER1L5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (87) LifeMap
- (88) miRTarBase
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- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
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- (115) ProteomicsDB
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- (141) ENCODE
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- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer