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Aliases for FER1L5 Gene

Aliases for FER1L5 Gene

  • Fer-1 Like Family Member 5 2 3 5
  • Fer-1-Like 5 (C. Elegans) 2

External Ids for FER1L5 Gene

Previous GeneCards Identifiers for FER1L5 Gene

  • GC08U900646
  • GC02P096673
  • GC02P097308

Summaries for FER1L5 Gene

GeneCards Summary for FER1L5 Gene

FER1L5 (Fer-1 Like Family Member 5) is a Protein Coding gene. An important paralog of this gene is DYSF.

UniProtKB/Swiss-Prot for FER1L5 Gene

  • Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L5 Gene

Genomics for FER1L5 Gene

Regulatory Elements for FER1L5 Gene

Enhancers for FER1L5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FER1L5 on UCSC Golden Path with GeneCards custom track

Promoters for FER1L5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FER1L5 Gene

Chromosome:
2
Start:
96,642,711 bp from pter
End:
96,706,220 bp from pter
Size:
63,510 bases
Orientation:
Plus strand

Genomic View for FER1L5 Gene

Genes around FER1L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER1L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L5 Gene

Proteins for FER1L5 Gene

  • Protein details for FER1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVI2-FR1L5_HUMAN
    Recommended name:
    Fer-1-like protein 5
    Protein Accession:
    A0AVI2
    Secondary Accessions:
    • Q17RH2
    • Q6ZU24

    Protein attributes for FER1L5 Gene

    Size:
    2093 amino acids
    Molecular mass:
    241963 Da
    Quaternary structure:
    • Interacts (via second C2 domain) with EHD1 and EHD2.

    Alternative splice isoforms for FER1L5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER1L5 Gene

Post-translational modifications for FER1L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FER1L5 Gene

No data available for DME Specific Peptides for FER1L5 Gene

Domains & Families for FER1L5 Gene

Gene Families for FER1L5 Gene

Protein Domains for FER1L5 Gene

Suggested Antigen Peptide Sequences for FER1L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0AVI2

UniProtKB/Swiss-Prot:

FR1L5_HUMAN :
  • Contains 6 C2 domains.
  • Belongs to the ferlin family.
Domain:
  • Contains 6 C2 domains.
Family:
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L5: view

Function for FER1L5 Gene

Molecular function for FER1L5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

Phenotypes for FER1L5 Gene

GenomeRNAi human phenotypes for FER1L5:
genes like me logo Genes that share phenotypes with FER1L5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FER1L5 Gene

Localization for FER1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L5 Gene

Cell membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FER1L5: view

No data available for Subcellular locations from COMPARTMENTS for FER1L5 Gene

Pathways & Interactions for FER1L5 Gene

SuperPathways for FER1L5 Gene

No Data Available

Interacting Proteins for FER1L5 Gene

Gene Ontology (GO) - Biological Process for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
genes like me logo Genes that share ontologies with FER1L5: view

No data available for Pathways by source and SIGNOR curated interactions for FER1L5 Gene

Drugs & Compounds for FER1L5 Gene

No Compound Related Data Available

Transcripts for FER1L5 Gene

mRNA/cDNA for FER1L5 Gene

(22) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FER1L5 Gene

Fer-1-like 5 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L5 Gene

No ASD Table

Relevant External Links for FER1L5 Gene

GeneLoc Exon Structure for
FER1L5
ECgene alternative splicing isoforms for
FER1L5

Expression for FER1L5 Gene

mRNA expression in normal human tissues for FER1L5 Gene

mRNA differential expression in normal tissues according to GTEx for FER1L5 Gene

This gene is overexpressed in Testis (x23.2) and Pancreas (x5.8).

Protein differential expression in normal tissues from HIPED for FER1L5 Gene

This gene is overexpressed in Rectum (14.8), Heart (8.4), Stomach (7.5), and Urinary Bladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FER1L5 Gene



NURSA nuclear receptor signaling pathways regulating expression of FER1L5 Gene:

FER1L5

SOURCE GeneReport for Unigene cluster for FER1L5 Gene:

Hs.534025
genes like me logo Genes that share expression patterns with FER1L5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FER1L5 Gene

Orthologs for FER1L5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FER1L5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FER1L5 34
  • 83.51 (n)
  • 78.31 (a)
dog
(Canis familiaris)
Mammalia FER1L5 34
  • 84.98 (n)
  • 79.66 (a)
mouse
(Mus musculus)
Mammalia Fer1l5 34
  • 80.4 (n)
  • 74.65 (a)
Fer1l5 16
chimpanzee
(Pan troglodytes)
Mammalia FER1L5 34
  • 99.17 (n)
  • 98.77 (a)
rat
(Rattus norvegicus)
Mammalia Fer1l5 34
  • 80.04 (n)
  • 73.48 (a)
Species where no ortholog for FER1L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FER1L5 Gene

ENSEMBL:
Gene Tree for FER1L5 (if available)
TreeFam:
Gene Tree for FER1L5 (if available)

Paralogs for FER1L5 Gene

Paralogs for FER1L5 Gene

(3) SIMAP similar genes for FER1L5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FER1L5: view

Variants for FER1L5 Gene

Sequence variations from dbSNP and Humsavar for FER1L5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4907201 - 96,662,257(+) ACTAA(C/T)TGGGG reference, missense
rs7599598 - 96,686,103(+) TCAAC(A/G)CCGTG reference, missense
rs7579051 -- 96,643,602(+) gcctc(A/G)gcctc intron-variant
rs7579054 -- 96,643,611(+) tccca(A/G)agtgc intron-variant
rs7580337 -- 96,680,597(+) CACTT(A/T)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FER1L5 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv2720413 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591690 CNV gain 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv469775 CNV loss 16826518
nsv526313 CNV loss 19592680
nsv834306 CNV loss 17160897
nsv834307 CNV loss 17160897

Relevant External Links for FER1L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FER1L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FER1L5 Gene

Disorders for FER1L5 Gene

Relevant External Links for FER1L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FER1L5

No disorders were found for FER1L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FER1L5 Gene

Publications for FER1L5 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 65
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for FER1L5 Gene

Sources for FER1L5 Gene

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