Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FER1L5 Gene

Aliases for FER1L5 Gene

  • Fer-1-Like Family Member 5 2 3
  • Fer-1-Like 5 (C. Elegans) 2

External Ids for FER1L5 Gene

Previous GeneCards Identifiers for FER1L5 Gene

  • GC08U900646
  • GC02P096673
  • GC02P097308

Summaries for FER1L5 Gene

GeneCards Summary for FER1L5 Gene

FER1L5 (Fer-1-Like Family Member 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FER1L5 Gene

  • Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L5 Gene

Genomics for FER1L5 Gene

Regulatory Elements for FER1L5 Gene

Genomic Location for FER1L5 Gene

Start:
96,642,737 bp from pter
End:
96,704,887 bp from pter
Size:
62,151 bases
Orientation:
Plus strand

Genomic View for FER1L5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FER1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L5 Gene

Proteins for FER1L5 Gene

  • Protein details for FER1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVI2-FR1L5_HUMAN
    Recommended name:
    Fer-1-like protein 5
    Protein Accession:
    A0AVI2
    Secondary Accessions:
    • Q17RH2
    • Q6ZU24

    Protein attributes for FER1L5 Gene

    Size:
    2093 amino acids
    Molecular mass:
    241963 Da
    Quaternary structure:
    • Interacts (via second C2 domain) with EHD1 and EHD2.

    Alternative splice isoforms for FER1L5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER1L5 Gene

Proteomics data for FER1L5 Gene at MOPED

Post-translational modifications for FER1L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FER1L5 Gene

No data available for DME Specific Peptides for FER1L5 Gene

Domains for FER1L5 Gene

Protein Domains for FER1L5 Gene

Suggested Antigen Peptide Sequences for FER1L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0AVI2

UniProtKB/Swiss-Prot:

FR1L5_HUMAN :
  • A0AVI2
Domain:
  • Contains 6 C2 domains.
Family:
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L5: view

No data available for Gene Families for FER1L5 Gene

Function for FER1L5 Gene

Molecular function for FER1L5 Gene

UniProtKB/Swiss-Prot Function: Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

Gene Ontology (GO) - Molecular Function for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FER1L5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FER1L5 Gene

Localization for FER1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L5 Gene

Cell membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FER1L5 Gene COMPARTMENTS Subcellular localization image for FER1L5 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FER1L5: view

Pathways for FER1L5 Gene

SuperPathways for FER1L5 Gene

No Data Available

Interacting Proteins for FER1L5 Gene

Gene Ontology (GO) - Biological Process for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
genes like me logo Genes that share ontologies with FER1L5: view

No data available for Pathways by source for FER1L5 Gene

Transcripts for FER1L5 Gene

mRNA/cDNA for FER1L5 Gene

(25) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FER1L5 Gene

Fer-1-like 5 (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L5 Gene

No ASD Table

Relevant External Links for FER1L5 Gene

GeneLoc Exon Structure for
FER1L5
ECgene alternative splicing isoforms for
FER1L5

Expression for FER1L5 Gene

mRNA expression in normal human tissues for FER1L5 Gene

mRNA differential expression in normal tissues according to GTEx for FER1L5 Gene

This gene is overexpressed in Testis (23.2) and Pancreas (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FER1L5 Gene

SOURCE GeneReport for Unigene cluster for FER1L5 Gene Hs.534025

genes like me logo Genes that share expressions with FER1L5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FER1L5 Gene

Orthologs for FER1L5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FER1L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FER1L5 35
  • 99.17 (n)
  • 98.77 (a)
cow
(Bos Taurus)
Mammalia FER1L5 35
  • 83.51 (n)
  • 78.31 (a)
dog
(Canis familiaris)
Mammalia FER1L5 35
  • 84.98 (n)
  • 79.66 (a)
mouse
(Mus musculus)
Mammalia Fer1l5 35
  • 80.4 (n)
  • 74.65 (a)
Fer1l5 16
rat
(Rattus norvegicus)
Mammalia Fer1l5 35
  • 80.04 (n)
  • 73.48 (a)
Species with no ortholog for FER1L5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FER1L5 Gene

ENSEMBL:
Gene Tree for FER1L5 (if available)
TreeFam:
Gene Tree for FER1L5 (if available)

Paralogs for FER1L5 Gene

Selected SIMAP similar genes for FER1L5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FER1L5: view

No data available for Paralogs for FER1L5 Gene

Variants for FER1L5 Gene

Sequence variations from dbSNP and Humsavar for FER1L5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs747757 -- 96,648,438(-) CCCTT(C/T)TTTCC intron-variant
rs749949 -- 96,647,713(+) CCTGC(C/G)CGGGA intron-variant
rs749950 -- 96,647,737(+) TCTTT(A/C)CCCTG intron-variant
rs867539 -- 96,692,700(+) GAGGA(C/T)GCCCC intron-variant
rs868168 -- 96,687,988(+) CACGC(A/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FER1L5 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
esv2720413 CNV Deletion 23290073
nsv469775 CNV Loss 16826518
nsv834306 CNV Loss 17160897
nsv874680 CNV Loss 21882294
nsv834307 CNV Loss 17160897
nsv526313 CNV Loss 19592680

Relevant External Links for FER1L5 Gene

HapMap Linkage Disequilibrium report
FER1L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FER1L5 Gene

Disorders for FER1L5 Gene

No disorders were found for FER1L5 Gene.

No data available for UniProtKB/Swiss-Prot for FER1L5 Gene

Publications for FER1L5 Gene

  1. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for FER1L5 Gene

Sources for FER1L5 Gene

Back to Top

Content