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Aliases for FER1L5 Gene

Aliases for FER1L5 Gene

  • Fer-1 Like Family Member 5 2 3 5
  • Fer-1-Like 5 (C. Elegans) 2

External Ids for FER1L5 Gene

Previous GeneCards Identifiers for FER1L5 Gene

  • GC08U900646
  • GC02P096673
  • GC02P097308

Summaries for FER1L5 Gene

GeneCards Summary for FER1L5 Gene

FER1L5 (Fer-1 Like Family Member 5) is a Protein Coding gene. An important paralog of this gene is MYOF.

UniProtKB/Swiss-Prot for FER1L5 Gene

  • Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

Additional gene information for FER1L5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L5 Gene

Genomics for FER1L5 Gene

Regulatory Elements for FER1L5 Gene

Enhancers for FER1L5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H096615 1 Ensembl ENCODE 13 -24.8 -24806 3 ELF3 KLF1 FOXA2 SAP130 KLF17 MAX CEBPG RAD21 RARA YY1 CNNM3 ARID5A FER1L5 KANSL3 LOC105373496 CNNM4 LMAN2L ITPRIPL1 SNRNP200 GC02P096595
GH02H096636 1.2 ENCODE 0.4 -5.0 -5004 2 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 SNRNP200 KANSL3 ANKRD36B TRIM43CP ENSG00000236847 ENSG00000237837 ANKRD36 STARD7-AS1 LMAN2L CIAO1
GH02H096600 1 ENCODE 0.3 -40.8 -40772 2 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 REST PPARG LMAN2L CIAO1 GC02P096595 FER1L5
GH02H096631 0.6 ENCODE 0.4 -10.4 -10395 1 CEBPA HLF SCRT2 ZC3H11A CEBPG FOS CIAO1 FER1L5 GC02P096595
GH02H096608 0.7 ENCODE 0.3 -33.9 -33914 1 TFAP4 SAP130 SOX6 NR2F1 MAFG RAD21 RARA ZNF316 IKZF1 HNF4A ARID5A LOC105373496 CNNM3 KANSL3 GC02P096595 FER1L5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FER1L5 on UCSC Golden Path with GeneCards custom track

Promoters for FER1L5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000120303 189 600 PKNOX1 RFX1 POLR2A IKZF1 PRDM10 BMI1

Genomic Location for FER1L5 Gene

Chromosome:
2
Start:
96,642,711 bp from pter
End:
96,706,220 bp from pter
Size:
63,510 bases
Orientation:
Plus strand

Genomic View for FER1L5 Gene

Genes around FER1L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER1L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L5 Gene

Proteins for FER1L5 Gene

  • Protein details for FER1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVI2-FR1L5_HUMAN
    Recommended name:
    Fer-1-like protein 5
    Protein Accession:
    A0AVI2
    Secondary Accessions:
    • Q17RH2
    • Q6ZU24

    Protein attributes for FER1L5 Gene

    Size:
    2093 amino acids
    Molecular mass:
    241963 Da
    Quaternary structure:
    • Interacts (via second C2 domain) with EHD1 and EHD2.

    Alternative splice isoforms for FER1L5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER1L5 Gene

Post-translational modifications for FER1L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FER1L5 Gene

Domains & Families for FER1L5 Gene

Gene Families for FER1L5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FER1L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0AVI2

UniProtKB/Swiss-Prot:

FR1L5_HUMAN :
  • Belongs to the ferlin family.
Family:
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L5: view

Function for FER1L5 Gene

Molecular function for FER1L5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

Phenotypes for FER1L5 Gene

GenomeRNAi human phenotypes for FER1L5:
genes like me logo Genes that share phenotypes with FER1L5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FER1L5 Gene

Localization for FER1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L5 Gene

Cell membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FER1L5: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FER1L5 Gene

Pathways & Interactions for FER1L5 Gene

SuperPathways for FER1L5 Gene

No Data Available

Interacting Proteins for FER1L5 Gene

Gene Ontology (GO) - Biological Process for FER1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
genes like me logo Genes that share ontologies with FER1L5: view

No data available for Pathways by source and SIGNOR curated interactions for FER1L5 Gene

Drugs & Compounds for FER1L5 Gene

No Compound Related Data Available

Transcripts for FER1L5 Gene

mRNA/cDNA for FER1L5 Gene

(22) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(8) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FER1L5 Gene

Fer-1-like 5 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L5 Gene

No ASD Table

Relevant External Links for FER1L5 Gene

GeneLoc Exon Structure for
FER1L5
ECgene alternative splicing isoforms for
FER1L5

Expression for FER1L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FER1L5 Gene

mRNA differential expression in normal tissues according to GTEx for FER1L5 Gene

This gene is overexpressed in Testis (x23.2) and Pancreas (x5.8).

Protein differential expression in normal tissues from HIPED for FER1L5 Gene

This gene is overexpressed in Rectum (14.8), Heart (8.4), Stomach (7.5), and Urinary Bladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FER1L5 Gene



NURSA nuclear receptor signaling pathways regulating expression of FER1L5 Gene:

FER1L5

SOURCE GeneReport for Unigene cluster for FER1L5 Gene:

Hs.534025
genes like me logo Genes that share expression patterns with FER1L5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FER1L5 Gene

Orthologs for FER1L5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FER1L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FER1L5 33
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia FER1L5 33
  • 84.98 (n)
cow
(Bos Taurus)
Mammalia FER1L5 33
  • 83.51 (n)
mouse
(Mus musculus)
Mammalia Fer1l5 16 33
  • 80.4 (n)
rat
(Rattus norvegicus)
Mammalia Fer1l5 33
  • 80.04 (n)
Species where no ortholog for FER1L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FER1L5 Gene

ENSEMBL:
Gene Tree for FER1L5 (if available)
TreeFam:
Gene Tree for FER1L5 (if available)

Paralogs for FER1L5 Gene

Paralogs for FER1L5 Gene

(3) SIMAP similar genes for FER1L5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FER1L5: view

Variants for FER1L5 Gene

Sequence variations from dbSNP and Humsavar for FER1L5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000011491 -- 96,653,092(+) GGTGC(A/C)TGTAA intron-variant
rs1000022031 -- 96,696,603(+) ATCTT(-/A)AAAAA intron-variant
rs1000053354 -- 96,696,797(+) CTACT(A/C)TGGAG intron-variant
rs1000075546 -- 96,703,997(+) TTTTA(A/G)TAGAG intron-variant
rs1000101200 -- 96,670,501(+) GGCAA(A/G)GTGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FER1L5 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv2720413 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591690 CNV gain 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv469775 CNV loss 16826518
nsv526313 CNV loss 19592680
nsv834306 CNV loss 17160897
nsv834307 CNV loss 17160897

Relevant External Links for FER1L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FER1L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FER1L5 Gene

Disorders for FER1L5 Gene

Relevant External Links for FER1L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FER1L5

No disorders were found for FER1L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FER1L5 Gene

Publications for FER1L5 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for FER1L5 Gene

Sources for FER1L5 Gene

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