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Aliases for FER1L4 Gene

Aliases for FER1L4 Gene

  • Fer-1-Like Family Member 4, Pseudogene (Functional) 2 3
  • C20orf124 3 4
  • Fer-1-Like 4 (C. Elegans), Pseudogene (Functional) 2
  • Fer-1-Like 4, Pseudogene (Functional) 3
  • Fer-1-Like 4 (C. Elegans) 2

External Ids for FER1L4 Gene

Previous HGNC Symbols for FER1L4 Gene

  • C20orf124

Previous GeneCards Identifiers for FER1L4 Gene

  • GC20M033904
  • GC20M034814
  • GC20M034861
  • GC20M034862
  • GC20M033609
  • GC20M034146
  • GC20M030924

Summaries for FER1L4 Gene

GeneCards Summary for FER1L4 Gene

FER1L4 (Fer-1-Like Family Member 4, Pseudogene (Functional)) is a Pseudogene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER1L4 Gene

Genomics for FER1L4 Gene

Regulatory Elements for FER1L4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FER1L4 Gene

Start:
35,558,737 bp from pter
End:
35,607,896 bp from pter
Size:
49,160 bases
Orientation:
Minus strand

Genomic View for FER1L4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FER1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L4 Gene

Proteins for FER1L4 Gene

  • Protein details for FER1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A9Z1Z3-FR1L4_HUMAN
    Recommended name:
    Fer-1-like protein 4
    Protein Accession:
    A9Z1Z3
    Secondary Accessions:
    • Q9GZQ9
    • Q9H646
    • Q9H8L7

    Protein attributes for FER1L4 Gene

    Size:
    1794 amino acids
    Molecular mass:
    200980 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14597.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FER1L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER1L4 Gene

Proteomics data for FER1L4 Gene at MOPED

Post-translational modifications for FER1L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FER1L4 Gene

Domains for FER1L4 Gene

Protein Domains for FER1L4 Gene

Suggested Antigen Peptide Sequences for FER1L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A9Z1Z3

UniProtKB/Swiss-Prot:

FR1L4_HUMAN :
  • A9Z1Z3
Domain:
  • Contains 5 C2 domains.
Family:
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L4: view

No data available for Gene Families for FER1L4 Gene

Function for FER1L4 Gene

Phenotypes for FER1L4 Gene

GenomeRNAi human phenotypes for FER1L4:
genes like me logo Genes that share phenotypes with FER1L4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FER1L4 Gene

Localization for FER1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FER1L4 Gene COMPARTMENTS Subcellular localization image for FER1L4 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FER1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FER1L4: view

Pathways for FER1L4 Gene

SuperPathways for FER1L4 Gene

No Data Available

Interacting Proteins for FER1L4 Gene

Gene Ontology (GO) - Biological Process for FER1L4 Gene

None

No data available for Pathways by source for FER1L4 Gene

Transcripts for FER1L4 Gene

Unigene Clusters for FER1L4 Gene

Fer-1-like 4 (C. elegans) pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FER1L4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L4 Gene

No ASD Table

Relevant External Links for FER1L4 Gene

GeneLoc Exon Structure for
FER1L4
ECgene alternative splicing isoforms for
FER1L4

Expression for FER1L4 Gene

mRNA expression in normal human tissues for FER1L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FER1L4 Gene

This gene is overexpressed in Bladder (12.0) and Stomach (9.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FER1L4 Gene

SOURCE GeneReport for Unigene cluster for FER1L4 Gene Hs.72222

genes like me logo Genes that share expressions with FER1L4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FER1L4 Gene

Orthologs for FER1L4 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for FER1L4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Fer1l4 16
Species with no ortholog for FER1L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FER1L4 Gene

ENSEMBL:
Gene Tree for FER1L4 (if available)
TreeFam:
Gene Tree for FER1L4 (if available)

Paralogs for FER1L4 Gene

Selected SIMAP similar genes for FER1L4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FER1L4: view

No data available for Paralogs for FER1L4 Gene

Variants for FER1L4 Gene

Sequence variations from dbSNP and Humsavar for FER1L4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs188878 -- 35,568,093(+) ctctg(A/C)ctcca intron-variant
rs224423 -- 35,560,079(+) agggc(C/T)ggagg intron-variant
rs224424 -- 35,560,231(+) GCGCC(A/G)GACGC nc-transcript-variant
rs224425 -- 35,560,522(+) GCCCC(A/G)CCCGG intron-variant
rs224426 -- 35,560,590(+) TCGTC(A/G)TCCAG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FER1L4 Gene

Variant ID Type Subtype PubMed ID
nsv517785 CNV Loss 19592680
nsv526796 CNV Loss 19592680
nsv178794 CNV Loss 16902084
nsv526188 CNV Gain 19592680
esv2664066 CNV Deletion 23128226
esv2722366 CNV Deletion 23290073
dgv698n67 CNV Loss 20364138

Relevant External Links for FER1L4 Gene

HapMap Linkage Disequilibrium report
FER1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FER1L4 Gene

Disorders for FER1L4 Gene

Relevant External Links for FER1L4

Genetic Association Database (GAD)
FER1L4
genes like me logo Genes that share disorders with FER1L4: view

No data available for UniProtKB/Swiss-Prot for FER1L4 Gene

Publications for FER1L4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48
  3. Long non-coding RNA expression profile in human gastric cancer and its clinical significances. (PMID: 24063685) Song H. … Guo J. (J Transl Med 2013) 2 3
  4. Clinical significance of the low expression of FER1L4 in gastric cancer patients. (PMID: 24961353) Liu Z. … Guo J. (Tumour Biol. 2014) 2 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4

Products for FER1L4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FER1L4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FER1L4
    • Block miRNA regulation of FER1L4 using miScript Target Protectors

    Sources for FER1L4 Gene

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