FER1L4 Gene
pseudogene GIFtS : 35
GCID: GC20 M034146
fer-1-like 4 (C. elegans) pseudogene (Previous name: fer-1-like 4 (C. elegans) ) (Previous symbol: C20orf124 )
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Aliasesfor FER1L4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Fer-1-Like 4 (C. Elegans) Pseudogene 1 2 C20orf1241 2 3 BA563A22B.11 DJ309K20.11 Fer-1-Like 4 (C. Elegans)1
External Ids: HGNC: 15801 1 Entrez Gene: 80307 2 Ensembl: ENSG00000088340 7 UniProtKB: A9Z1Z3 3 ORGUL members: NONCODE:n387194 n339660 n346155 n406891
Export aliases for FER1L4 gene to outside databases Previous GC identifers: GC20M033904 GC20M034814 GC20M034861 GC20M034862 GC20M033609 GC20M030924
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Summariesfor FER1L4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor FER1L4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011362.10 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FER1L4 gene promoter: Pax-5 MEF-2 Brachyury ATF-2 YY1 HNF-4alpha1 CRE-BP1 HEN1 MEF-2A aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for FER1L4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FER1L4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q11.22 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.23 FER1L4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M034146: view genomic region
(about GC identifiers )
Start:
34,146,507 bp from pter
End:
34,195,484 bp from pter
Size:
48,978 bases
Orientation:
minus strand
ORGUL member locations:Legend (see complete legend)
n406891
n346155
n387194
n339660
34146506 34170995 34195484 chr20
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Proteinsfor FER1L4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FR1L4_HUMAN, A9Z1Z3 (See
protein sequence )Recommended Name: Fer-1-like protein 4 Size : 1794 amino acids; 200980 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Sequence caution : Sequence=BAB14597.1; Type=Erroneous initiation;
Secondary accessions : Q9GZQ9 Q9H646 Q9H8L7Alternative splicing : 4 isoforms : A9Z1Z3-1 A9Z1Z3-2 A9Z1Z3-3 A9Z1Z3-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FER1L4: NX_A9Z1Z3 FER1L4 Protein expression data from MOPED and PaxDb : About this image
Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
FER1L4 for ontologies About GeneDecksing FER1L4 Antibody Products: Assay Products for FER1L4:
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Protein
Domains / Familiesfor FER1L4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FER1L4 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry A9Z1Z3 ProtoNet protein and cluster: A9Z1Z3
UniProtKB/Swiss-Prot: FR1L4_HUMAN, A9Z1Z3 Similarity : Belongs to the ferlin familySimilarity : Contains 5 C2 domains
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Functionfor FER1L4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER1L4
1 GenomeRNAi human phenotype for FER1L4 :
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Pathways & Interactionsfor FER1L4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FER1L4
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Drugs & Compoundsfor FER1L4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FER1L4 Search CenterWatch for drugs/clinical trials and news about FER1L4
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Transcriptsfor FER1L4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Vector BioLabs ,
Primers from
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SABiosciences , and/or
QIAGEN
)About This Section Unigene Cluster for FER1L4:
Fer-1-like 4 (C. elegans) pseudogene Hs.72222 [show with all ESTs ] Unigene Representative Sequence: NR_024377 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000434828 ENST00000262870 ENST00000400461 (uc002xcx.3 ) ENST00000411519 (uc010gfg.1 )ENST00000400465 ENST00000431615 (uc002xcy.4 ) ENST00000440443 ENST00000452272 ENST00000430275 ENST00000412452 ENST00000325076 (uc010zvh.1 ) ENST00000434843 ENST00000426117 Additional cDNA sequence: AF218012.1 AF218030.1 AL833764.1 AY461812.1 BC029951.1 BX648024.1 NR_024377.1
14 DOTS entries : DT.105430 DT.99965692 DT.101978898 DT.97779387 DT.95336958 DT.95265673 DT.70101289 DT.100717011
DT.120818642 DT.91668661 DT.91679080 DT.99933710 DT.120818635 DT.65284360 23 AceView cDNA sequences :
AA600159 AL929481 BC029951 R74490 AK026266 AW135429 AI741534 BX366900 AI189057 BX379397 BI827331 AW451439 BF732507 AI206080 AW205318 BX339596 BX390528 BQ109511 AL548157 BG010720 R74601 AW298094 BG506859 GeneLoc Exon Structure
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Expression for FER1L4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FER1L4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGAGCTACCC
About this image FER1L4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FER1L4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FER1L4 SOURCE GeneReport for Unigene cluster: Hs.72222 SABiosciences Custom PCR Arrays for FER1L4 Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat FER1L4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FER1L4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FER1L4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER1L4
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Orthologsfor FER1L4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for FER1L4 gene from 1 species (see representative species ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Fer1l45
fer-1-like 4 (C. elegans)
--
 
2 (77.32 cM) 156019139
ENSEMBL Gene Tree for FER1L4 (if available)TreeFam Gene Tree for FER1L4 (if available)
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Paralogsfor FER1L4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor FER1L4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 20 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FER1L4 (34146507 - 34195484 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for FER1L4 2 CNVs : 6096 50650
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FER1L4
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Disorders
/ Diseasesfor FER1L4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FER1L4 for disorders About GeneDecksing 1 disease for FER1L4 : About MalaCards muscular dystrophy Export disorders for FER1L4 gene to outside databases
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Publicationsfor FER1L4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FER1L4 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with FER1L4) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565) 1 Teslovich T.M....Kathiresan S. (2010) In silico functional and structural characterisation of ferlin proteins by mapping disease-causing mutations and evolutionary information onto three-dimensional models of their C2 domains. (PubMed id 17512949) 1 Jimenez J.L. and Bashir R. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Dysferlin and the plasma membrane repair in muscular dystrophy. (PubMed id 15066638) 1 Bansal D. and Campbell K.P. (2004) Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 1 Brandenberger R.... Stanton L.W. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874) 2 Wan D....Gu J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 2 Deloukas P....Rogers J. (2001)
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External Searches for FER1L4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FER1L4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FER1L4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FER1L4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FER1L4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FER1L4 gene: Search GeneIP for patents involving FER1L4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FER1L4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FER1L4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FER1L4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FER1L4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FER1L4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FER1L4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FER1L4
Search Tocris compounds for FER1L4
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER1L4
Search ThermoFisher Antibodies for FER1L4
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FER1L4
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Function for FER1L4
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