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Aliases for FER Gene

Aliases for FER Gene

  • FER Tyrosine Kinase 2 3 5
  • Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer 3 4
  • Protein Phosphatase 1, Regulatory Subunit 74 2 3
  • Feline Encephalitis Virus-Related Kinase FER 3 4
  • Fer (Fps/Fes Related) Tyrosine Kinase 2 3
  • Phosphoprotein NCP94 2 3
  • Proto-Oncogene C-Fer 3 4
  • Tyrosine Kinase 3 3 4
  • EC 2.7.10.2 4 61
  • P94-Fer 3 4
  • TYK3 3 4
  • Tyrosine-Protein Kinase Fer 3
  • EC 2.7.10 61
  • PPP1R74 3

External Ids for FER Gene

Previous GeneCards Identifiers for FER Gene

  • GC05P107703
  • GC05P108524
  • GC05P108114
  • GC05P108159
  • GC05P108111
  • GC05P103255

Summaries for FER Gene

Entrez Gene Summary for FER Gene

  • The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

GeneCards Summary for FER Gene

FER (FER Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FER include Leukemia, Acute Myeloid. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Remodeling of Adherens Junctions. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FES.

UniProtKB/Swiss-Prot for FER Gene

  • Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Gene Wiki entry for FER Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER Gene

Genomics for FER Gene

Regulatory Elements for FER Gene

Enhancers for FER Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G109468 1.3 Ensembl ENCODE 20.2 +722.7 722731 0.4 PKNOX1 FOXA2 ARID4B FEZF1 ZNF2 ZNF766 ZNF143 MXD4 REST ZNF662 FER ENSG00000251367 LOC105379117
GH05G109484 1 ENCODE 25.2 +738.9 738939 0.9 FOXA2 MLX ARID4B ZNF48 YY1 SP5 MXD4 NFYC MIER2 PPARG FER LOC285638 ENSG00000248440 ENSG00000248876
GH05G108800 1.3 FANTOM5 Ensembl ENCODE 16.7 +55.8 55793 1.8 TBP ATF1 JUN SIN3A MAX CHD7 CEBPG RFX5 FOSL1 FOS FER ENSG00000250383 LOC100422561
GH05G108735 1 FANTOM5 19.2 -10.2 -10158 0.4 HDAC1 PKNOX1 ATF1 ELK1 GATA2 FOS CREM NCOA1 REST MEF2D FER GC05P108729
GH05G108685 1.3 FANTOM5 Ensembl ENCODE 11.5 -59.4 -59448 2.1 ELF3 SOX13 FOXA2 SAP130 ARID4B RBBP5 ZNF48 RARA YY1 FOXK2 FER GC05M108715 PIR47866
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FER on UCSC Golden Path with GeneCards custom track

Genomic Location for FER Gene

Chromosome:
5
Start:
108,746,085 bp from pter
End:
109,196,841 bp from pter
Size:
450,757 bases
Orientation:
Plus strand

Genomic View for FER Gene

Genes around FER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER Gene

Proteins for FER Gene

  • Protein details for FER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16591-FER_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fer
    Protein Accession:
    P16591
    Secondary Accessions:
    • B2RCR4
    • B4DSQ2
    • H2FLB8

    Protein attributes for FER Gene

    Size:
    822 amino acids
    Molecular mass:
    94638 Da
    Quaternary structure:
    • Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA and regulates its phosphorylation at Thr-320 (By similarity). Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1.

    Three dimensional structures from OCA and Proteopedia for FER Gene

    Alternative splice isoforms for FER Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER Gene

Selected DME Specific Peptides for FER Gene

P16591:
  • TKKSGVVL
  • RDLAARN
  • KWTAPEA
  • WYHGAIPR
  • LGELLGKGNFGEVYKG
  • ILKQYDHPNIVKLIG
  • GGDFLTFLR
  • CIHRDLAARNCLV
  • PYPGMTN
  • LKISDFGMSR
  • KFLQEAKILKQY
  • YSSESDVWSFGILLWE
  • HAEDLNSGPL
  • LHNQYVLA

Post-translational modifications for FER Gene

Domains & Families for FER Gene

Graphical View of Domain Structure for InterPro Entry

P16591

UniProtKB/Swiss-Prot:

FER_HUMAN :
  • The coiled coil domains mediate homooligomerization and are required for location at microtubules.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
Domain:
  • The coiled coil domains mediate homooligomerization and are required for location at microtubules.
  • The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
genes like me logo Genes that share domains with FER: view

Function for FER Gene

Molecular function for FER Gene

GENATLAS Biochemistry:
fer (fps/fes related) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Enzyme Numbers (IUBMB) for FER Gene

Gene Ontology (GO) - Molecular Function for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS 2725517
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA,IEA 12972546
GO:0005154 epidermal growth factor receptor binding IEA,IDA 21518868
GO:0005515 protein binding IPI 15226396
genes like me logo Genes that share ontologies with FER: view
genes like me logo Genes that share phenotypes with FER: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FER Gene

Localization for FER Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FER gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 1990274
GO:0005634 nucleus IDA,IEA 19147545
GO:0005737 cytoplasm IEA,IDA 1990274
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FER: view

Pathways & Interactions for FER Gene

genes like me logo Genes that share pathways with FER: view

SIGNOR curated interactions for FER Gene

Activates:

Gene Ontology (GO) - Biological Process for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 12972546
GO:0000278 mitotic cell cycle IMP 22223638
GO:0001932 regulation of protein phosphorylation ISS --
GO:0006468 protein phosphorylation TAS,IEA 2725517
GO:0006935 chemotaxis IBA --
genes like me logo Genes that share ontologies with FER: view

Drugs & Compounds for FER Gene

(4) Drugs for FER Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Dovitinib (TKI-258, CHIR-258) Pharma Multitargeted RTK inhibitor 0

(2) Additional Compounds for FER Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for FER Gene

Compound Action Cas Number
Dovitinib (TKI-258, CHIR-258) Multitargeted RTK inhibitor 405169-16-6
genes like me logo Genes that share compounds with FER: view

Drug Products

Transcripts for FER Gene

Unigene Clusters for FER Gene

Fer (fps/fes related) tyrosine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER Gene

No ASD Table

Relevant External Links for FER Gene

GeneLoc Exon Structure for
FER
ECgene alternative splicing isoforms for
FER

Expression for FER Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FER Gene

Protein differential expression in normal tissues from HIPED for FER Gene

This gene is overexpressed in Lung (46.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FER Gene



NURSA nuclear receptor signaling pathways regulating expression of FER Gene:

FER

SOURCE GeneReport for Unigene cluster for FER Gene:

Hs.221472

mRNA Expression by UniProt/SwissProt for FER Gene:

P16591-FER_HUMAN
Tissue specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for FER Gene

  • Nervous system(4.3)
  • Spleen(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with FER: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FER Gene

Orthologs for FER Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FER Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FER 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia FER 34 35
  • 93.27 (n)
mouse
(Mus musculus)
Mammalia Fer 16 35
  • 93 (a)
Fert2 34
  • 88.44 (n)
cow
(Bos Taurus)
Mammalia FER 34 35
  • 91.16 (n)
oppossum
(Monodelphis domestica)
Mammalia FER 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FER 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fert2 34
  • 86.26 (n)
chicken
(Gallus gallus)
Aves FER 34 35
  • 81.31 (n)
lizard
(Anolis carolinensis)
Reptilia FER 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fer 34
  • 73.99 (n)
zebrafish
(Danio rerio)
Actinopterygii fer 34 35
  • 71.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fps85D 36 34 35
  • 48.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003651 34
  • 48.06 (n)
worm
(Caenorhabditis elegans)
Secernentea kin-14 36 34 35
  • 49.42 (n)
T21G5.1 36 35
  • 41 (a)
C35E7.10b 36
  • 38 (a)
ZK622.1 36 35
  • 38 (a)
C25A8.5 36 35
  • 37 (a)
C35E7.10a 36
  • 37 (a)
C55C3.4 36 35
  • 37 (a)
F26E4.5 36 35
  • 37 (a)
W04G5.10 36
  • 37 (a)
frk-1 36 35
  • 37 (a)
F01D4.3 36
  • 36 (a)
F23C8.7 36 35
  • 36 (a)
F57B9.8 36 35
  • 36 (a)
T06C10.3 36 35
  • 36 (a)
F46F5.2 36
  • 35 (a)
T14E8.1a 36
  • 35 (a)
T14E8.1b 36
  • 35 (a)
kin-26 36 35
  • 34 (a)
R05H5.4 36 35
  • 34 (a)
C18H7.4 36 35
  • 33 (a)
F09A5.2 36
  • 33 (a)
kin-23 36
  • 33 (a)
ZC581.7 36 35
  • 33 (a)
R11E3.1 36
  • 32 (a)
spe-8 36 35
  • 32 (a)
W03F8.2 36 35
  • 32 (a)
T25B9.4 36 35
  • 31 (a)
C35E7.10 35
  • 31 (a)
ManyToMany
K09B11.5 36
  • 30 (a)
T25B9.5 36
  • 30 (a)
Y69E1A.3 36
  • 30 (a)
ZK593.9 36 35
  • 29 (a)
W02A2.4 36
  • 28 (a)
Y4C6A.1 36 35
  • 28 (a)
Y52D5A.2 36
  • 28 (a)
kin-31 35
  • 28 (a)
ManyToMany
kin-6 35
  • 28 (a)
ManyToMany
Y43C5B.2 35
  • 28 (a)
ManyToMany
F59A3.8 36 35
  • 27 (a)
kin-24 36 35
  • 26 (a)
W01B6.5 36 35
  • 26 (a)
Y116A8C.24 36 35
  • 25 (a)
Y116A8C.38 36 35
  • 25 (a)
kin-5 35
  • 24 (a)
ManyToMany
F22B3.8 35
  • 23 (a)
ManyToMany
Y106G6A.1 35
  • 20 (a)
ManyToMany
B0252.1 35
  • 18 (a)
ManyToMany
W03A5.1 35
  • 15 (a)
ManyToMany
C34F11.5 35
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for FER was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FER Gene

ENSEMBL:
Gene Tree for FER (if available)
TreeFam:
Gene Tree for FER (if available)

Paralogs for FER Gene

Paralogs for FER Gene

genes like me logo Genes that share paralogs with FER: view

Variants for FER Gene

Sequence variations from dbSNP and Humsavar for FER Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_041692 An ovarian Endometrioid carcinoma sample
VAR_041695 A lung small cell carcinoma sample
rs1000001532 -- 109,124,907(+) CAGGC(G/T)TAGTG intron-variant
rs1000008741 -- 108,906,511(+) ATAGC(C/T)CTTTT intron-variant
rs1000011571 -- 108,925,969(+) AGTGA(C/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FER Gene

Variant ID Type Subtype PubMed ID
esv2450464 CNV deletion 19546169
esv2502982 CNV insertion 19546169
esv2668245 CNV deletion 23128226
esv2677654 CNV deletion 23128226
esv2730582 CNV deletion 23290073
esv3566428 CNV deletion 23714750
esv3566430 CNV deletion 23714750
esv3570334 CNV loss 25503493
esv3606212 CNV loss 21293372
esv3606214 CNV loss 21293372
esv3890706 CNV gain 25118596
nsv1016343 CNV gain 25217958
nsv1074323 CNV deletion 25765185
nsv1129748 CNV tandem duplication 24896259
nsv327356 CNV insertion 16902084
nsv471039 CNV gain 18288195
nsv475926 CNV novel sequence insertion 20440878
nsv4952 CNV deletion 18451855
nsv4953 CNV deletion 18451855
nsv509988 OTHER sequence alteration 20534489
nsv512857 CNV insertion 21212237
nsv525993 CNV loss 19592680
nsv830443 CNV gain 17160897
nsv968974 CNV duplication 23825009
nsv969258 CNV deletion 23825009

Variation tolerance for FER Gene

Residual Variation Intolerance Score: 5.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FER Gene

Human Gene Mutation Database (HGMD)
FER
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FER

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FER Gene

Disorders for FER Gene

MalaCards: The human disease database

(1) MalaCards diseases for FER Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FER in MalaCards View complete list of genes associated with diseases

Relevant External Links for FER

Genetic Association Database (GAD)
FER
Human Genome Epidemiology (HuGE) Navigator
FER
Tumor Gene Database (TGDB):
FER
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FER
genes like me logo Genes that share disorders with FER: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FER Gene

Publications for FER Gene

  1. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PMID: 19147545) Zoubeidi A. … Chevalier S. (Mol. Cancer Res. 2009) 3 4 22 64
  2. Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes. (PMID: 19339212) Oh M.A. … Lee J.W. (Biochim. Biophys. Acta 2009) 3 4 22 64
  3. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. (PMID: 19738202) Itoh T. … Takenawa T. (Sci. Signal. 2009) 3 4 22 64
  4. Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. (PMID: 12972546) Kogata N. … Mochizuki N. (Mol. Biol. Cell 2003) 3 4 22 64
  5. Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. (PMID: 14517306) Miravet S. … Garcia de Herreros A. (Mol. Cell. Biol. 2003) 3 4 22 64

Products for FER Gene

  • Addgene plasmids for FER

Sources for FER Gene

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