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Aliases & Descriptions for FER
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.7.10.2 3 | | TYK3 1, 2, 3, 5 | | c-FER 3 | | p94-FER 3 |
| | | Descriptions |
|---|
| Tyrosine kinase 3 3 | | fer (fps/fes related) tyrosine kinase 2 | | phosphoprotein NCP94 2 |
|
| | Search outside databases for aliases for FER genePrevious GC identifers: GC05P107703 GC05P108524 GC05P108114 GC05P108159 |
Summaries for FER(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FER: Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq] UniProtKB/Swiss-Prot: FER_HUMAN, P16591Function: Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle controlGene Wiki entry for FER |
Genomic Location for FER
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FER gene 
Entrez Gene cytogenetic band: 5q21 Ensembl cytogenetic band: 5q21.3 HGNC cytogenetic band: 5q21FER Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P108111:
(about GC identifiers)
Start:
|
108,111,422 bp from pter |
End:
|
108,551,272 bp from pter |
Size:
|
439,851 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000005.8 NT_034772.5
| Proteins for FER
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FER_HUMAN, P16591 (See
protein sequence)Recommended Name: Proto-oncogene tyrosine-protein kinase FER Size: 822 amino acids; 94638 Da
Subcellular location: Cytoplasm. Nucleus. Note=Associated with the chromatinPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005237.2
ENSEMBL proteins: ENSP00000281092
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for FER: Assays for FER: | Protein
Domains/ Families for FER(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P16591
ProtoNet protein and cluster: P16591 3 Blocks protein families: IPB000980 SH2 domain signature IPB001060 Cdc15/Fes/CIP4 IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: FER_HUMAN, P16591Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamilySimilarity: Contains 1 FCH domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domain | Gene Function for FER
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005246
Applied Biosystems Silencer® siRNAs for FER
Sigma-Aldrich siRNA and siRNA Panels for FER  Sigma-Aldrich shRNA Panels and shRNA for FER  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005246                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005246                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005246 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005246
UniProtKB/Swiss-Prot: FER_HUMAN, P16591Function: Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle controlCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme Number (IUBMB): EC 2.7.10.2 Genatlas biochemistry entry for FER:fer (fps/fes related) oncogene homolog1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Fert2):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FER
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for FER (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FER 
5 Interacting proteins for FER (P165912) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007242 | intracellular signaling cascade |
TAS | 2209086 | | GO:0018108 | peptidyl-tyrosine phosphorylation |
IEA | -- | About this table
|
Drugs & Compounds for FER(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FER 3 Novoseek chemical compound relationships for FER gene
About this table
|
Transcripts for FER(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005246
Sigma-Aldrich siRNA and siRNA Panels for FER  Sigma-Aldrich shRNA Panels and shRNA for FER  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005246 REFSEQ mRNAs for FER gene: NM_005246.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005246               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005246                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005246                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005246  Additional cDNA sequence: AK293376.1 AK296874.1 AK299855.1 AK315234.1 BC017060.1 BC058030.1 CR612158.1 J03358.1 9 DOTS entries: DT.204962 DT.91664750 DT.100015683 DT.101956348 DT.100664607 DT.100743018 DT.95147128 DT.97773964 DT.95197173 24/28 AceView cDNA sequences (see all 28
):AL553206 BM461740 BE464122 BM836424 J03358 CR612158 NM_005246 BX111092 BX329084 BC017060 BQ948178 BG611933 AI969987 CB120902 BG199979 BX645595 BX327980 BE620300 BU155168 AA534773 AI654758 CB853071 BC058030 CF129502
highest scoring ESTs for FER:J03358 AA534773 AI654758 AI918808 AI969987 BE464122 BE548973 BG199979 BQ948178 CF129502 Unigene Cluster for FER: Fer (fps/fes related) tyrosine kinase Hs.221472 [show with all ESTs]Unigene Representative Sequence: AK299855
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000281092
|
Expression for FER
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FER expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FER
1 / 2 / 3 4 probe-sets matching FER gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGCAATTCC
SOURCE GeneReport for Unigene cluster: Hs.221472
Expression variation in blood from EXPOLDB for FER UniProtKB/Swiss-Prot: FER_HUMAN, P16591Tissue specificity: Expressed in a variety of lymphoid cell lines |
Orthologs for FER
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FER gene from 5/9 species (see all 9
)
About this table Species with no ortholog for FER
ENSEMBL Gene Tree for FER | Paralogs for FER(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FER gene
- FES2
|
SNPs/Variants for FER(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FER (up to first 250kb)
|
Disorders & Mutations for FER
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 176942
5 Novoseek disease relationships for FER gene
About this table
Human Gene Mutation Database: FER Tumor Gene Database: FER
|
Medical News for FER(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FER (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/71 PubMed articles for FER gene (see all 71
):- Nuclear and cytoplasmic location of the FER tyrosine kinase. (PubMed id 1990274)1, 3, 4 Hao Q.-L.... Groffen J. (1991)
- Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)3, 4 Wissing J.... Daub H. (2007)
- A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. (PubMed id 8247543)3, 4 Lee S.-T.... Spritz R.A. (1993)
- Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. (PubMed id 1651563)3, 4 Nishisho I....Hedge P. (1991)
- Identification and chromosomal mapping of new human tyrosine kinase genes. (PubMed id 2156206)3, 4 Krolewski J.J.... Dalla-Favera R. (1990)
- Isolation and sequence analysis of a novel human tyrosine kinase gene. (PubMed id 2725517)3, 4 Hao Q.-L.... Groffen J. (1989)
- Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells. (PubMed id 12738762)1, 3 Taler M....Nir U. (2003)
- N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo. (PubMed id 10998246)1, 3 Orlovsky K....Nir U. (2000)
- Involvement of the tyrosine kinase fer in cell adhesion. (PubMed id 9742093)1, 3 Rosato R....Heisterkamp N. (1998)
- Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. (PubMed id 16732323)1, 3 Pasder O....Nir U. (2006)
|
Search for FER
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FER
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FER
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FER(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FER(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FER:

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| Antibodies & Assays for FER  |
| | Recombinant Proteins (FER) | | Antibodies (FER) |
| | | Search Tocris compounds for FER |
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Incremental update: 13 Oct 2009
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