FER Gene
protein-coding GIFtS: 68
GCID: GC05P108111
|
|
fer (fps/fes related) tyrosine kinase
| |
Aliases
for FER gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fer (Fps/Fes Related) Tyrosine Kinase1 2 | | P94-Fer1 | | TYK31 2 3 5 | | EC 2.7.10.23 8 | | PPP1R741 2 | | FerT2 | | Feline Encephalitis Virus-Related Kinase FER2 3 | | Phosphoprotein NCP942 | | Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer2 3 | | Protein Phosphatase 1, Regulatory Subunit 742 | | Proto-Oncogene C-Fer2 3 | | Tyrosine-Protein Kinase Fer2 | | Tyrosine Kinase 32 3 | | EC 2.7.108 |
Export aliases for FER gene to outside databasesPrevious GC identifers: GC05P107703 GC05P108524 GC05P108114 GC05P108159 GC05P103255 |
Summaries
for FER gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FER:
Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-celladhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FER_HUMAN, P16591Function: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role inthe regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migrationand chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation ofNF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in theinsulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of theactivated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signalingin mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment anddiapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking ofsynaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays arole in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. Mayphosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type andstimulus
Gene Wiki entry for FER
|
Genomic Views
for FER gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FER gene promoter:
NF-1 NF-1/L p53 Egr-1 GATA-1 AREB6 Max STAT3 AP-2alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for FER
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FER |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q21 Ensembl cytogenetic band: 5q21.3 HGNC cytogenetic band: 5q21FER Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P108111: view genomic region
(about GC identifiers)
Start:
|
108,083,523 bp from pter |
End:
|
108,532,542 bp from pter |
Size:
|
449,020 bases |
Orientation:
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plus strand |
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Proteins
for FER gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FER_HUMAN, P16591 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Fer Size: 822 amino acids; 94638 Da
Subunit: Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA andregulates its phosphorylation at 'Thr-320' (By similarity). Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR andSTAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FERagainst proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cellcortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelialcells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts
1 PDB 3D structure from  and Proteopedia  for FER:2KK6 (3D)
Secondary accessions: B2RCR4 B4DSQ2 H2FLB8Alternative promoter usage, Alternative splicing: 3 isoforms: P16591-1 P16591-2 P16591-3 (Produced by alternative promoter usage)Explore the universe of human proteins at neXtProt for FER: NX_P16591
Post-translational modifications:
Autophosphorylated1
Polyubiquitinated; this leads to proteasomal degradation (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P16591
4/14 DME Specific Peptides for FER (P16591) (see all 14)
FER Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005237.2
ENSEMBL proteins: ENSP00000281092 ENSP00000421951 ENSP00000442627 ENSP00000394297 Reactome Protein details: P16591
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
FER for ontologies About GeneDecksing
FER Antibody Products:
Assay Products for FER: |
Protein
Domains /
Families
for FER gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FER for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry P16591ProtoNet protein and cluster: P16591 3 Blocks protein families: IPB000980 SH2 domain signature IPB001060 Cdc15/Fes/CIP4 IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: FER_HUMAN, P16591Domain: The coiled coil domains mediate homooligomerization and are required for location at microtubulesDomain: The N-terminal region including the first coiled coil domain mediates interaction withphosphoinositide-containing membranesSimilarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamilySimilarity: Contains 1 FCH domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domain |
Function
for FER gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FER_HUMAN, P16591Function: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role inthe regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migrationand chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation ofNF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in theinsulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of theactivated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signalingin mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment anddiapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking ofsynaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays arole in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. Mayphosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type andstimulusCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated byreactive oxygen species (ROS) Genatlas biochemistry entry for FER:fer (fps/fes related) oncogene homolog
Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FER
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FER (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FER (NM_005246) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FER | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FER |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER |
Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16): About this table
FER for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for FER:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Fer):
FER for phenotypes About GeneDecksing
|
Pathways & Interactions
for FER gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response Fc epsilon RI pathway | | | 2 | Neurophysiological process Receptor-mediated axon growth repulsion | | | 3 | Cytoskeleton remodeling Slit-Robo signaling | | | 4 | Tyrosine Kinases / Adaptors | | | 5 | Lymphocyte Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for FER
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FER
2 
Cell Signaling Technology (CST) Pathways for FER
3  GeneGo (Thomson Reuters) Pathways for FER
5/6  BioSystems Pathways for FER (see all 6)
2 
Reactome Pathways for FER
1 
Kegg Pathway (Kegg details for FER):
FER for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FER
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for FER (P165912, 3 ENSP000002810924) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table
FER for ontologies About GeneDecksing
|
Drugs & Compounds
for FER gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FER for compounds About GeneDecksing
 Browse Tocris compounds for FER
2 HMDB Compounds for FER About this table
3 Novoseek chemical compound relationships for FER gene About this table
Search CenterWatch for drugs/clinical trials and news about FER
|
Transcripts
for FER gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FER gene: NM_005246.2 Unigene Cluster for FER: Fer (fps/fes related) tyrosine kinase Hs.221472 [show with all ESTs]Unigene Representative Sequence: AK2998559 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281092(uc011cvf.1 uc003kop.1) ENST00000509035 ENST00000513676
ENST00000504143(uc011cvg.1) ENST00000502752(uc003koq.2) ENST00000505323
ENST00000513777 ENST00000536402(uc011cve.1) ENST00000438717
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FER
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FER (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FER (NM_005246) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FER | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FER |
Additional cDNA sequence: AK293376.1 AK296874.1 AK299855.1 AK315234.1 BC017060.1 BC058030.1 J03358.1 JQ412173.1 9 DOTS entries: DT.204962 DT.91664750 DT.100015683 DT.101956348 DT.100664607 DT.100743018 DT.95147128 DT.95197173 DT.97773964 24/28 AceView cDNA sequences (see all 28): BM461740 BX111092 J03358 AL553206 NM_005246 CR612158 BM836424 BE464122 BX645595 BE620300 BX329084 BX327980 BG199979 BQ948178 AI969987 CB120902 BC017060 BG611933 BU155168 CF129502 BC058030 AI654758 AA534773 CB853071
GeneLoc Exon Structure
|
Expression
for FER gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FER expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCAATTCC
About this image
See FER Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FER
SOURCE GeneReport for Unigene cluster: Hs.221472
UniProtKB/Swiss-Prot: FER_HUMAN, P16591Tissue specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detectedin normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepatocarcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (atprotein level). Widely expressed
SABiosciences Custom PCR Arrays for FER
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FER
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FER | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FER | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FER | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER |
Orthologs
for FER gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FER gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FER1 |
fer (fps/fes related) tyrosine kinase |
81.31(n)
87.96(a) |
|
415614 XM_413981.3 XP_413981.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FER6 |
-- |
86(a) |
1 ↔ 1 |
GL343193.1(5107475-5255823) |
zebrafish
(Danio rerio) |
Actinopterygii |
fer1 |
fer (fps/fes related) tyrosine kinase |
71.1(n)
77.68(a) |
|
565199 XM_688484.4 XP_693576.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Fps85D1 , 3 |
photoreceptor morphogenesis (sensu
Drosophila) more3
Fps oncogene analog1 |
37(a)3
48.41(n)1
41.78(a)1 |
|
411181 NM_079564.31 NP_524288.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
T21G5.13
kin-141 |
tyrosine-protein kinase3
Protein KIN-141 |
41(a)
(best of 39)3
49.33(n)1
40.7(a)1 |
|
I(6882444-6884994)3
1724401 NM_059603.51 NP_492004.11 |
ENSEMBL Gene Tree for FER (if available)
TreeFam Gene Tree for FER (if available) |
Paralogs
for FER gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FER gene
- DSTYK2 MATK2 CSK2 FES2
18/33 SIMAP similar genes for FER using alignment to 5 protein entries: FER_HUMAN (see all proteins)
(see all similar genes):ABL1 EPHA2 tec FES SHC3 BTK
FGR FRK SRC DKFZp434L0319 PTK6 CSK
FGFR2 FGFR3 urf-ret HCK TIE1 FYN
FER for paralogs About GeneDecksing
|
Genomic Variants
for FER gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FER (108083523 - 108333523 bp, first 250kb of FER)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FER
1 CNV: 99251
1 Indel: 99250 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FER |
|
Disorders
/ Diseases
for FER gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FER for disorders About GeneDecksing
OMIM gene information: 176942
OMIM disorders: --
14  diseases for FER: About MalaCardsadult-onset still's disease encephalitis sarcoma myeloid leukemia
prostate cancer hermaphroditism prostatitis colon carcinoma
hepatocellular carcinoma leukemia carcinoma colorectal cancer
anemia neuronitis
1 disease from the University of Copenhagen DISEASES database for FER:Acute myeloid leukemia 5 Novoseek disease relationships for FER gene About this table
Human Genome Epidemiology (HuGE) Navigator: FER (8 documents)
Tumor Gene Database (TGDB): FER
Export disorders for FER gene to outside databases
|
Publications
for FER gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FER gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with FER) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. (PubMed id 12972546)1, 2, 9 Kogata N....Mochizuki N. (2003)
- The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PubMed id 19147545)1, 2, 9 Zoubeidi A....Chevalier S. (2009)
- Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes. (PubMed id 19339212)1, 2, 9 Oh M.A....Lee J.W. (2009)
- The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. (PubMed id 19738202)1, 2, 9 Itoh T....Takenawa T. (2009)
- Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. (PubMed id 14517306)1, 2, 9 Miravet S....Garcia de Herreros A. (2003)
- Nuclear and cytoplasmic location of the FER tyrosine kinase. (PubMed id 1990274)1, 2, 9 Hao Q.-L.... Groffen J. (1991)
- Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. (PubMed id 9722593)1, 2, 9 Kim L. and Wong T.W. (1998)
- Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells. (PubMed id 22223638)1, 2 Makovski A.... Nir U. (2012)
- FER tyrosine kinase (FER) overexpression mediates res istance to quinacrine through EGF-dependent activation of NF-kappaB. (PubMed id 21518868)1, 2 Guo C. and Stark G.R. (2011)
- Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids. (PubMed id 18985748)1, 2 Kierszenbaum A.L....Tres L.L. (2008)
|
External Searches for FER gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FER gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FER gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FER gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FER gene:
Search GeneIP for patents involving FER
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FER gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for FER | | OriGene shRNA RFP for FER | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FER | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FER | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FER | | OriGene 3'-UTR Clone for FER | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FER | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FER | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FER | | OriGene Custom Protein Services for FER | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FER | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FER | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FER | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FER | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FER | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FER |
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| | Antibodies & Assays for FER |
| | | | Search Tocris compounds for FER |
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 | | | FER Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER |
|  |  |  | | | | ThermoFisher Antibody for FER |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FER |
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