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FER Gene

protein-coding   GIFtS: 72
GCID: GC05P108111

Fer (Fps/Fes Related) Tyrosine Kinase

  See FER-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fer (Fps/Fes Related) Tyrosine Kinase1 2     FerT2
TYK32 3 5     PPP1R742
Phosphoprotein NCP941 2     Pe1Fe102
Feline Encephalitis Virus-Related Kinase FER2 3     Pe1Fe132
Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer2 3     Pe1Fe32
Proto-Oncogene C-Fer2 3     Pe1Fe62
Tyrosine Kinase 32 3     Protein Phosphatase 1, Regulatory Subunit 742
p94-Fer2 3     Truncated Fer (Fps/Fes Related) Tyrosine Kinase2
EC 2.7.10.23 8     Tyrosine-Protein Kinase Fer2
Protein Phosphatase 11     EC 2.7.108
Regulatory Subunit 741     

External Ids:    HGNC: 36551   Entrez Gene: 22412   Ensembl: ENSG000001514227   OMIM: 1769425   UniProtKB: P165913   

Export aliases for FER gene to outside databases

Previous GC identifers: GC05P107703 GC05P108524 GC05P108114 GC05P108159 GC05P103255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FER Gene:
Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates
cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FER Gene:
FER (fer (fps/fes related) tyrosine kinase) is a protein-coding gene. Diseases associated with FER include encephalitis, and sarcoma. GO annotations related to this gene include lipid binding and actin binding. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: FER_HUMAN, P16591
Function: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a
role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion,
cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to
promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell
cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.
Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon
receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a
role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in
synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and
neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN,
CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the
biological relevance of this depends on cell type and stimulus

Gene Wiki entry for FER Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FER gene promoter:
         NF-1   NF-1/L   p53   Egr-1   GATA-1   AREB6   Max   STAT3   AP-2alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FER promoter sequence
   Search Chromatin IP Primers for FER

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21   Ensembl cytogenetic band:  5q21.3   HGNC cytogenetic band: 5q21

FER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FER gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P108111:  view genomic region     (about GC identifiers)

Start:
108,083,523 bp from pter      End:
108,532,542 bp from pter
Size:
449,020 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FER_HUMAN, P16591 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fer  
Size: 822 amino acids; 94638 Da
Subunit: Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA and
regulates its phosphorylation at 'Thr-320' (By similarity). Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and
STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and
protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and
PTK2/FAK1
1 PDB 3D structure from and Proteopedia for FER:
2KK6 (3D)    
Secondary accessions: B2RCR4 B4DSQ2 H2FLB8
Alternative promoter usage, Alternative splicing: 3 isoforms:  P16591-1   P16591-2   P16591-3   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for FER: NX_P16591

Explore proteomics data for FER at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Polyubiquitinated; this leads to proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys610
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FER (P16591) (see all 14)
     KWTAPEA  RDLAARN  PYPGMTN  TKKSGVVL 


    See FER Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005237.2  
    ENSEMBL proteins: 
     ENSP00000281092   ENSP00000421951   ENSP00000442627   ENSP00000394297  
    Reactome Protein details: P16591

    FER Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FER Protein
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    Novus Biologicals FER Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FER

     
    Search eBioscience for Proteins for FER 

     
    Search antibodies-online for proteins for FER 

     
    antibodies-online peptides for FER

    FER Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FER
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    Novus Biologicals FER Antibodies
    Abcam antibodies for FER
    Cloud-Clone Corp. Antibodies for FER
    ThermoFisher Antibody for FER
    LSBio Antibodies in human, mouse, rat for FER
    antibodies-online antibodies for FER (95 products) 

    FER Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FER
    Browse R&D Systems for biochemical assays
    GenScript FER-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FER
    Cloud-Clone Corp. CLIAs for FER
    Search eBioscience for ELISAs for FER 
    antibodies-online kits for FER (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: fer (fps/fes related) tyrosine kinase
    Fer family

    Selected InterPro protein domains (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR001060 FCH_dom
     IPR011009 Kinase-like_dom
     IPR016250 Tyr-prot_kinase_Fes/Fps
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P16591

    ProtoNet protein and cluster: P16591

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001060 Cdc15/Fes/CIP4
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FER_HUMAN, P16591
    Domain: The coiled coil domains mediate homooligomerization and are required for location at microtubules
    Domain: The N-terminal region including the first coiled coil domain mediates interaction with
    phosphoinositide-containing membranes
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with FER           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FER_HUMAN, P16591
    Function: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a
    role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion,
    cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to
    promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell
    cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.
    Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon
    receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a
    role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in
    synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and
    neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN,
    CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the
    biological relevance of this depends on cell type and stimulus
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by
    reactive oxygen species (ROS)

         Genatlas biochemistry entry for FER:
    fer (fps/fes related) oncogene homolog

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS2725517
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA12972546
    GO:0005154epidermal growth factor receptor binding IDA--
         
    Find genes that share ontologies with FER           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for FER:
     Decreased Wnt reporter activit  Decreased substrate adherent c  Increased apoptosis  Increased colony dispersion (i 
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Fer):
     normal 

    Find genes that share phenotypes with FER           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FER
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FER

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FER
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FER

    miRNA
    Products:
        
    miRTarBase miRNAs that target FER:
    hsa-mir-17-5p (MIRT051027), hsa-mir-26a-5p (MIRT050063), hsa-mir-26a-2-3p (MIRT038279)

    Block miRNA regulation of human, mouse, rat FER using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FER
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FER
    Predesigned siRNA for gene silencing in human, mouse, rat FER

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FER (NM_005246)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FER
    Addgene plasmids for FER 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FER


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FER_HUMAN, P16591: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic
    side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
    Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile
    vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at
    nascent cell-cell contacts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790colocalizes with nuclear chromatin IDA1990274
    GO:0005634nucleus IDA19147545
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005938cell cortex IEA--

    Find genes that share ontologies with FER           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FER About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2PI-3K cascade
    Signaling by SCF-KIT0.72
    3Signaling by GPCR
    Signal Transduction0.58
    4Development Slit Robo signaling
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    5Sertoli-Sertoli Cell Junction Dynamics
    Germ Cell-Sertoli Cell Junction Dynamics0.38


    Find genes that share SuperPaths with FER           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FER
        Remodeling of Adherens Junctions
    Germ Cell-Sertoli Cell Junction Dynamics
    Transendothelial Migration of Leukocytes
    Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for FER
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for FER
        Neurophysiological process Receptor-mediated axon growth repulsion
    Immune response Fc epsilon RI pathway
    Cell adhesion Cadherin-mediated cell adhesion

    Selected BioSystems Pathways for FER (see all 6)
        Integrated Breast Cancer Pathway
    N-cadherin signaling events
    PDGFR-beta signaling pathway
    Signaling events mediated by PTP1B
    Fc-epsilon receptor I signaling in mast cells

    1 Reactome Pathway for FER
        Signaling by SCF-KIT


    1 Kegg Pathway  (Kegg details for FER):
        Adherens junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FER
    Interactions:

        GeneGlobe Interaction Network for FER

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FER (P165911, 2, 3 ENSP000002810924) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464592, 3, ENSP000003812934MINT-8217341 I2D: score=2 STRING: ENSP00000381293
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908123 I2D: score=1 STRING: ENSP00000365312
    ERBB2P046262, 3, ENSP000002695714MINT-74533 I2D: score=1 STRING: ENSP00000269571
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IMP12972546
    GO:0000278mitotic cell cycle IMP--
    GO:0001932regulation of protein phosphorylation ISS--
    GO:0006468protein phosphorylation TAS2725517
    GO:0006935chemotaxis IEA--

    Find genes that share ontologies with FER           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FER

    2 HMDB Compounds for FER    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 Novoseek inferred chemical compound relationships for FER gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 67.1 99 11006284 (6), 12738762 (5), 12972546 (5), 19159681 (5) (see all 29)
    iron 29.5 9 8144027 (1), 8861664 (1), 11427634 (1), 16060121 (1) (see all 6)
    phosphatidylinositol 22.8 7 11006284 (3), 12738762 (1)



    Find genes that share compounds with FER           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FER gene: 
    NM_005246.2  

    Unigene Cluster for FER:

    Fer (fps/fes related) tyrosine kinase
    Hs.221472  [show with all ESTs]
    Unigene Representative Sequence: AK299855
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281092(uc011cvf.1 uc003kop.1) ENST00000509035 ENST00000513676
    ENST00000504143(uc011cvg.1) ENST00000502752(uc003koq.2) ENST00000505323
    ENST00000513777 ENST00000536402(uc011cve.1) ENST00000438717
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FER
    Addgene plasmids for FER 
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    OriGene qSTAR qPCR primer pairs in human, mouse for FER
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FER
      QuantiTect SYBR Green Assays in human, mouse, rat FER
      QuantiFast Probe-based Assays in human, mouse, rat FER

    Additional mRNA sequence: 

    AK293376.1 AK296874.1 AK299855.1 AK315234.1 BC017060.1 BC058030.1 J03358.1 JQ412173.1 

    9 DOTS entries:

    DT.204962  DT.91664750  DT.100015683  DT.101956348  DT.100664607  DT.100743018  DT.95147128  DT.95197173 
    DT.97773964 

    Selected AceView cDNA sequences (see all 28):

    NM_005246 BX111092 J03358 BM461740 BE464122 BM836424 CR612158 AL553206 
    BX645595 BX329084 BE620300 BG611933 BU155168 BQ948178 BG199979 CB120902 
    BC017060 AI969987 BX327980 AA534773 AI654758 CF129502 BC058030 CB853071 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FER expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAATTCC
    FER Expression
    About this image


    FER expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Placenta (Extraembryonic Tissues)
    FER Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FER Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.221472

    UniProtKB/Swiss-Prot: FER_HUMAN, P16591
    Tissue specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is
    detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma
    and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal
    fibroblasts (at protein level). Widely expressed

        Custom PCR Arrays for FER
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FER gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fer5
    Fert21
    fer (fms/fps related) protein kinase5
    fer (fms/fps related) protein kinase, testis specific more1
    88.44(n)1
    93.07(a)1
      17 (33.06 cM)5
    141581  NM_001037997.31  NP_001033086.21 
     638960185 
    chicken
    (Gallus gallus)
    Aves FER1 fer (fps/fes related) tyrosine kinase 81.31(n)
    87.96(a)
      415614  XM_413981.4  XP_413981.2 
    lizard
    (Anolis carolinensis)
    Reptilia FER6
    fer (fps/fes related) tyrosine kinase
    85(a)
    1 ↔ 1
    GL343193.1(5106706-5255823)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fer1 fer (fps/fes related) tyrosine kinase 73.99(n)
    79.6(a)
      549656  NM_001016902.2  NP_001016902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fer1 fer (fps/fes related) tyrosine kinase 71.1(n)
    77.68(a)
      565199  XM_688484.5  XP_693576.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fps85D1 , 3 photoreceptor morphogenesis (sensu
    Drosophila) more3
    Fps oncogene analog1
    37(a)3
    48.14(n)1
    41.3(a)1
      411181  NM_001275482.11  NP_001262411.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T21G5.13
    kin-141
    tyrosine-protein kinase3
    kin-141
    41(a)
    (best of 39)3
    49.42(n)1
    40.7(a)1
      I(6882444-6884994)3
    1724401  NM_059603.61  NP_492004.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC156
    Protein kinase of the Mitotic Exit Network that is...
    9(a)
    1 → many
    I(172211-175135) YAR019C


    ENSEMBL Gene Tree for FER (if available)
    TreeFam Gene Tree for FER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FER gene
    TEC2  CSK2  ITK2  TXK2  FES2  DSTYK2  MATK2  BMX2  
    BTK2  
    Selected SIMAP similar genes for FER using alignment to 5 protein entries:     FER_HUMAN (see all proteins) (see all similar genes):
    ABL1    EPHA2    tec    FES    SHC3    BTK
    FGR    FRK    SRC    DKFZp434L0319    PTK6    CSK
    FGFR2    FGFR3    urf-ret    HCK    TIE1    FYN

    Find genes that share paralogs with FER           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FER (see all 9114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0416954
    A lung small cell carcinoma sample4--see VAR_0416952 W C mis40--------
    VAR_0416924
    An ovarian Endometrioid carcinoma sample4--see VAR_0416922 E Q mis40--------
    rs719820691,2
    C--103298237(+) CACAC-/CACACAC 1 -- int10--------
    rs131874291,2
    C--103352991(+) tgtgtA/GtgtgT 1 -- int11Minor allele frequency- G:0.00WA 2
    rs105426821,2
    C--103697078(+) TTTGTAAAC/-  
            
    AAACA
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs113416271,2
    C--108091858(+) ATCTC-/AAAAAA 1 -- int1 trp30--------
    rs789729391,2
    C,F--108096242(+) GAGTTT/CTGGAT 1 -- int12Minor allele frequency- C:0.12WA 120
    rs557518431,2
    C--108096639(+) TTTTT-/TGAGAT 1 -- int10--------
    rs2008913081,2
    C--108105634(+) ATGAT-/GA    
       T
    /TGA
    TTTTT
    2 -- cds10--------
    rs572662481,2
    C--108106624(+) TTTTTT/-CTCTG 1 -- int11Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for FER (108083523 - 108333523 bp, first 250kb of FER)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FER (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677654CNV Deletion23128226
    esv2450464CNV Deletion19546169
    esv2730582CNV Deletion23290073
    esv2668245CNV Deletion23128226
    esv2502982CNV Insertion19546169
    nsv327356CNV Insertion16902084
    nsv512857CNV Insertion21212237
    dgv6291n71CNV Loss21882294
    nsv525993CNV Loss19592680
    nsv509988CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176942    OMIM disorders: --

    2 diseases for FER:    
    About MalaCards
    encephalitis    sarcoma

    1 disease from the University of Copenhagen DISEASES database for FER:
    Leukemia

    Find genes that share disorders with FER           About GenesLikeMe

    5 Novoseek inferred disease relationships for FER gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 22.4 2 10687853 (2)
    metaplasia 20.3 1 10687853 (1)
    prostate cancer 4.09 11 19147545 (7), 10687853 (1)
    tumors 0 1 19147545 (1)
    cancer 0 2 16732323 (1), 10687853 (1)

    Genetic Association Database (GAD): FER
    Human Genome Epidemiology (HuGE) Navigator: FER (8 documents)
    Tumor Gene Database (TGDB): FER

    Export disorders for FER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FER gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with FER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. (PubMed id 12972546)1, 2, 9 Kogata N....Mochizuki N. (Mol. Biol. Cell 2003)
    2. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PubMed id 19147545)1, 2, 9 Zoubeidi A.... Chevalier S. (Mol. Cancer Res. 2009)
    3. Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes. (PubMed id 19339212)1, 2, 9 Oh M.A.... Lee J.W. (Biochim. Biophys. Acta 2009)
    4. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. (PubMed id 19738202)1, 2, 9 Itoh T.... Takenawa T. (Sci. Signal. 2009)
    5. Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. (PubMed id 14517306)1, 2, 9 Miravet S....Garcia de Herreros A. (Mol. Cell. Biol. 2003)
    6. Nuclear and cytoplasmic location of the FER tyrosine kinase. (PubMed id 1990274)1, 2, 9 Hao Q.-L.... Groffen J. (Mol. Cell. Biol. 1991)
    7. Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. (PubMed id 9722593)1, 2, 9 Kim L. and Wong T.W. (J. Biol. Chem. 1998)
    8. Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells. (PubMed id 22223638)1, 2 Makovski A.... Nir U. (J. Biol. Chem. 2012)
    9. FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. (PubMed id 21518868)1, 2 Guo C. and Stark G.R. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2241 HGNC: 3655 AceView: FER Ensembl:ENSG00000151422 euGenes: HUgn2241
    ECgene: FER Kegg: 2241 H-InvDB: FER

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FER Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FER Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FER gene:
    Search GeneIP for patents involving FER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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