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Aliases for FENDRR Gene

Subcategory (RNA class) for FENDRR Gene


Quality Score for this RNA gene is


Aliases for FENDRR Gene

  • FOXF1 Adjacent Non-Coding Developmental Regulatory RNA 2 3
  • FOXF1 Antisense RNA 1 (Head To Head) 2 3
  • TCONS_00024240 3 6
  • FOXF1 Antisense RNA 1 (Non-Protein Coding) 3
  • LincFOXF1 3
  • FOXF1-AS1 3
  • FOXF1AS1 6

External Ids for FENDRR Gene

Previous HGNC Symbols for FENDRR Gene

  • FOXF1-AS1

Summaries for FENDRR Gene

Entrez Gene Summary for FENDRR Gene

  • This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

GeneCards Summary for FENDRR Gene

FENDRR (FOXF1 Adjacent Non-Coding Developmental Regulatory RNA) is an RNA Gene, and is affiliated with the lncRNA class.

fRNAdb sequence ontologies for FENDRR Gene

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for FENDRR Gene

Genomics for FENDRR Gene

Genomic Location for FENDRR Gene

86,474,525 bp from pter
86,509,099 bp from pter
34,575 bases
Minus strand

Genomic View for FENDRR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FENDRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FENDRR Gene

No data available for Regulatory Elements for FENDRR Gene

Proteins for FENDRR Gene

Post-translational modifications for FENDRR Gene

No Post-translational modifications

No data available for DME Specific Peptides for FENDRR Gene

Domains for FENDRR Gene

Gene Families for FENDRR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FENDRR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FENDRR Gene

Function for FENDRR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FENDRR Gene

Localization for FENDRR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FENDRR Gene

Pathways for FENDRR Gene

SuperPathways for FENDRR Gene

No Data Available

Interacting Proteins for FENDRR Gene

Gene Ontology (GO) - Biological Process for FENDRR Gene


No data available for Pathways by source for FENDRR Gene

Transcripts for FENDRR Gene

Unigene Clusters for FENDRR Gene

FOXF1 adjacent non-coding developmental regulatory RNA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FENDRR Gene

No ASD Table

Relevant External Links for FENDRR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FENDRR Gene

mRNA expression in normal human tissues for FENDRR Gene

mRNA differential expression in normal tissues according to GTEx for FENDRR Gene

This gene is overexpressed in Colon - Sigmoid (9.1), Esophagus - Gastroesophageal Junction (7.5), Esophagus - Muscularis (6.8), Bladder (6.1), and Lung (4.4).

SOURCE GeneReport for Unigene cluster for FENDRR Gene Hs.448825

genes like me logo Genes that share expressions with FENDRR: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FENDRR Gene

Orthologs for FENDRR Gene

Evolution for FENDRR Gene

Gene Tree for FENDRR (if available)
Gene Tree for FENDRR (if available)

No data available for Orthologs for FENDRR Gene

Paralogs for FENDRR Gene

No data available for Paralogs for FENDRR Gene

Variants for FENDRR Gene

Sequence variations from dbSNP and Humsavar for FENDRR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs39520 -- 86,495,105(+) GCAGG(A/G)CGGCT intron-variant
rs39521 -- 86,494,521(+) ACTGG(A/C)CTGAT intron-variant
rs39522 -- 86,493,263(+) GGGGA(C/T)GACCT intron-variant
rs39523 -- 86,492,563(-) ACACA(C/T)CAGTT intron-variant
rs39524 -- 86,490,942(+) ATGCA(A/G)TTGCT intron-variant, nc-transcript-variant

Relevant External Links for FENDRR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FENDRR Gene

Disorders for FENDRR Gene

No disorders were found for FENDRR Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FENDRR Gene

Publications for FENDRR Gene

  1. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M. … Rinn J.L. (Elife 2013) 2 3
  2. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. (PMID: 19571010) Khalil A.M. … Rinn J.L. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3
  3. Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. (PMID: 23034409) Szafranski P. … Stankiewicz P. (Genome Res. 2013) 2 3
  4. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. (PMID: 23369715) Grote P. … Herrmann B.G. (Dev. Cell 2013) 2 3
  5. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. (PMID: 23563609) Wheeler E. … Farooqi I.S. (Nat. Genet. 2013) 3

Products for FENDRR Gene

Sources for FENDRR Gene

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