Subcategory (RNA class) for FENDRR Gene
Quality Score for this RNA gene is
Aliases for FENDRR Gene
ORGUL Members for FENDRR Gene
Previous HGNC Symbols for FENDRR Gene
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
GeneCards Summary for FENDRR Gene
FENDRR (FOXF1 Adjacent Non-Coding Developmental Regulatory RNA) is an RNA Gene, and is affiliated with the lncRNA class.
fRNAdb sequence ontologies for FENDRR Gene
ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.