Aliases for FEN1 Gene
Aliases for FEN1 Gene
External Ids for FEN1 Gene
- HGNC: 3650
- Entrez Gene: 2237
- Ensembl: ENSG00000168496
- OMIM: 600393
- UniProtKB: P39748
Previous HGNC Symbols for FEN1 Gene
- RAD2
Previous GeneCards Identifiers for FEN1 Gene
- GC11P064074
- GC11P063135
- GC11P061335
- GC11P061316
- GC11P061560
- GC11P057888
Summaries for FEN1 Gene
-
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
GeneCards Summary for FEN1 Gene
FEN1 (Flap Structure-Specific Endonuclease 1) is a Protein Coding gene. Diseases associated with FEN1 include Vitelliform Macular Dystrophy and Xeroderma Pigmentosum, Group G. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include magnesium ion binding and damaged DNA binding. An important paralog of this gene is GEN1.
UniProtKB/Swiss-Prot for FEN1 Gene
-
Structure-specific nuclease with 5-flap endonuclease and 5-3 exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5-end of a downstream Okazaki fragment. It enters the flap from the 5-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5-3 exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEN1 Gene
Genomics for FEN1 Gene
Regulatory Elements for FEN1 Gene
Enhancers for FEN1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FEN1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FEN1 gene promoter:
Regulatory Element Products
Genomic Location for FEN1 Gene
- Chromosome:
- 11
- Start:
- 61,792,637 bp from pter
- End:
- 61,797,244 bp from pter
- Size:
- 4,608 bases
- Orientation:
- Plus strand
Genomic View for FEN1 Gene
Genes around FEN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.2 by Ensembl
- 11q12.2 by Entrez Gene
- 11q12.2 by HGNC
FEN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FEN1 Gene
Proteins for FEN1 Gene
-
Protein details for FEN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P39748-FEN1_HUMAN
- Recommended name:
- Flap endonuclease 1
- Protein Accession:
- P39748
Protein attributes for FEN1 Gene
- Size:
- 380 amino acids
- Molecular mass:
- 42593 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer (PubMed:15616578). PCNA stimulates the nuclease activity without altering cleavage specificity (PubMed:15616578). The C-terminal domain binds EP300; can bind simultaneously to both PCNA and EP300 (PubMed:11430825). Interacts with PCNA; can bind simultaneously to both PCNA and EP300 (PubMed:9305916, PubMed:11430825). Interacts with DDX11; this interaction is direct and increases flap endonuclease activity of FEN1 (PubMed:18499658).
Three dimensional structures from OCA and Proteopedia for FEN1 Gene
Protein Expression for FEN1 Gene
Post-translational modifications for FEN1 Gene
- Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
- Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
- Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
- Ubiquitination at isoforms=8, Lys171, and Lys345
- Modification sites at PhosphoSitePlus
Other Protein References for FEN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for FEN1 (FEN1)
-
Custom Antibody ServicesOriGene Antibodies for FEN1
- AP06687PU-N
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- TA802762AM
- CF802774
- TA802774
- CF802764
- TA802764
- CF802763
- TA802763
- CF802762
- TA802762
- TA346947
- TA346946
- TA339264
- TA326972
- Novus Biologicals Antibodies for FEN1
- Invitrogen Antibodies for FEN1
- antibodies-online Antibodies for FEN1: See all 109
- GeneTex FEN1 antibody for FEN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FEN1
Protein Products
-
OriGene Purified Proteins for FEN1
- Search Origene for MassSpec and Protein Over-expression Lysates for FEN1
- Origene Custom Protein Services for FEN1
- ProSpec Recombinant Proteins for FEN1
- antibodies-online Proteins for FEN1: See all 60
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FEN1
-
ProSci Proteins for FEN1
Assay Products
- antibodies-online Kits for FEN1: See all 5
No data available for DME Specific Peptides for FEN1 Gene
Domains & Families for FEN1 Gene
Protein Domains for FEN1 Gene
Suggested Antigen Peptide Sequences for FEN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P39748- Family:
-
- Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
No data available for Gene Families for FEN1 Gene
Function for FEN1 Gene
Molecular function for FEN1 Gene
- GENATLAS Biochemistry:
- flap structure specific endonuclease 1,with an 5- 3 exonuclease activity,involved in long patch base excision repair,DNA replication,where it processes Okazaki fragments,recombination and repair where it interacts with PCNA complex and DNA and acts as an exonuclease
- UniProtKB/Swiss-Prot Function:
- Structure-specific nuclease with 5-flap endonuclease and 5-3 exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5-end of a downstream Okazaki fragment. It enters the flap from the 5-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5-3 exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Enzyme Numbers (IUBMB) for FEN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA,IMP | 11986308 |
| GO:0003684 | damaged DNA binding | TAS | 8007985 |
| GO:0003690 | double-stranded DNA binding | TAS | 8131753 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
Phenotypes for FEN1 Gene
- MGI mutant phenotypes for FEN1:
-
inferred from 8 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for FEN1:
-
- Increased viability
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FEN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEN1 gene
- Search ViGene Biosciences for FEN1
CRISPR Products
-
OriGene CRISPR knockouts for FEN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEN1
- GenScript: Design CRISPR guide RNA sequences for FEN1
miRNA for FEN1 Gene
- miRTarBase miRNAs that target FEN1
-
- hsa-mir-24-3p (MIRT000116)
- hsa-mir-193b-3p (MIRT016610)
- hsa-mir-215-5p (MIRT024421)
- hsa-mir-34a-5p (MIRT025481)
- hsa-mir-192-5p (MIRT026838)
- hsa-mir-1229-3p (MIRT036309)
- hsa-mir-324-3p (MIRT042974)
- hsa-mir-183-5p (MIRT047080)
- hsa-let-7b-5p (MIRT052079)
- hsa-mir-140-5p (MIRT267491)
- hsa-mir-1253 (MIRT267492)
- hsa-mir-4293 (MIRT267494)
- hsa-mir-4324 (MIRT267495)
- hsa-mir-4251 (MIRT267496)
- hsa-mir-4795-5p (MIRT267500)
- hsa-mir-6719-3p (MIRT267504)
- hsa-mir-6770-5p (MIRT267506)
- hsa-mir-6807-5p (MIRT267507)
- hsa-mir-8055 (MIRT267508)
- hsa-mir-610 (MIRT333716)
- hsa-mir-651-3p (MIRT333717)
- hsa-mir-1200 (MIRT333718)
- hsa-mir-548n (MIRT333719)
- hsa-mir-548av-3p (MIRT333726)
- hsa-mir-6124 (MIRT333728)
- hsa-mir-628-5p (MIRT567554)
- hsa-mir-7152-5p (MIRT567555)
- hsa-mir-3074-5p (MIRT567556)
- hsa-mir-378a-5p (MIRT567557)
- hsa-mir-5087 (MIRT567558)
- hsa-mir-6823-3p (MIRT567559)
- hsa-mir-2114-3p (MIRT567560)
- hsa-mir-544b (MIRT567561)
- hsa-mir-885-5p (MIRT567562)
- hsa-mir-6800-3p (MIRT567563)
- hsa-mir-8054 (MIRT567564)
- hsa-mir-548k (MIRT567565)
- hsa-mir-548av-5p (MIRT567566)
- hsa-mir-548g-3p (MIRT567567)
miRNA Products
- Search ViGene Biosciences for FEN1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEN1
- Browse OriGene Inhibitory RNA Products For FEN1
-
ViGene Biosciences ready-to-package AAV shRNAs for FEN1 gene
Clone Products
- Sino Biological Human cDNA Clone for FEN1
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- Addgene plasmids for FEN1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FEN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FEN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FEN1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12168) for FEN1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FEN1 Gene
Localization for FEN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FEN1 Gene
- Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
- Isoform FENMIT: Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
| GO:0005634 | nucleus | IDA | 7961795 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005739 | mitochondrion | IDA | 18995831 |
Pathways & Interactions for FEN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | HIV Life Cycle |
.92
.65
|
.45
|
| 4 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.78
|
| 5 | Cell Cycle, Mitotic |
.83
|
|
Pathways by source for FEN1 Gene
1 Cell Signaling Technology pathway for FEN1 Gene
29 Reactome pathways for FEN1 Gene
3 KEGG pathways for FEN1 Gene
2 GeneGo (Thomson Reuters) pathways for FEN1 Gene
2 Qiagen pathways for FEN1 Gene
Interacting Proteins for FEN1 Gene
Selected Interacting proteins:
P39748-FEN1_HUMAN
ENSP00000305480
for FEN1 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000722 | telomere maintenance via recombination | TAS | -- |
| GO:0000724 | double-strand break repair via homologous recombination | TAS | -- |
| GO:0006260 | DNA replication | TAS | 9778254 |
| GO:0006281 | DNA repair | TAS,IEA | 8007985 |
| GO:0006284 | base-excision repair | IEA | -- |
Transcripts for FEN1 Gene
mRNA/cDNA for FEN1 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (427) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FEN1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FEN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FEN1
- GenScript: Design CRISPR guide RNA sequences for FEN1
miRNA Products
- Search ViGene Biosciences for FEN1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FEN1
- Browse OriGene Inhibitory RNA Products For FEN1
-
ViGene Biosciences ready-to-package AAV shRNAs for FEN1 gene
Clone Products
- Sino Biological Human cDNA Clone for FEN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FEN1
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12168) for FEN1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: |
Expression for FEN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (11.7) and Lavage (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEN1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FEN1 Gene:
FEN1SOURCE GeneReport for Unigene cluster for FEN1 Gene:
Hs.409065Evidence on tissue expression from TISSUES for FEN1 Gene
- Lung(4.8)
- Liver(4.3)
- Nervous system(4.2)
- Eye(2.8)
- Bone marrow(2.1)
- Heart(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for FEN1
-
OriGene qPCR primer pairs and template standards for FEN1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEN1 Gene
Orthologs for FEN1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FEN1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FEN1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FEN1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fen1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fen1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FEN1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FEN1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FEN1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FEN1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fen1 34 |
|
||
| Str.3319 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | fen1-B 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fen1 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.569 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011448 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fen1 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y47G6A.8 36 |
|
|
|
| crn-1 34 35 |
|
||||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABL052C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD27 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F02992g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G26680 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0540100 34 |
|
||
| Os.4469 34 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.6646 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.3072 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7233 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU10776 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rad2 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2215 34 |
|
- Species where no ortholog for FEN1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FEN1 Gene
(1) SIMAP similar genes for FEN1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for FEN1 Gene
Variants for FEN1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006148 | -- | 61,796,864(+) | GGCCA(A/C)CTGGT | utr-variant-3-prime | |
| rs1001813317 | -- | 61,794,721(+) | GACTG(A/C)GTGGT | intron-variant | |
| rs1002391793 | -- | 61,794,793(+) | TCTTA(C/T)GTGCT | intron-variant | |
| rs1002676540 | -- | 61,792,969(+) | ACCGC(A/C)TGCCC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1002728911 | -- | 61,793,307(+) | TCCTG(-/CCTA)CCTGT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.24;
40.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FEN1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEN1 Gene
Disorders for FEN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vitelliform macular dystrophy |
|
|
| xeroderma pigmentosum, group g |
|
|
| werner syndrome |
|
|
| bloom syndrome |
|
|
| best vitelliform macular dystrophy |
|
|
Search FEN1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FEN1
No data available for UniProtKB/Swiss-Prot and Genatlas for FEN1 Gene
Publications for FEN1 Gene
- Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. (PMID: 7774922) Hiraoka L.R. … Hsieh C.-L. (Genomics 1995) 2 3 4 22 64
- Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. (PMID: 19618370) Yang M. … Lin D. (Hum. Mutat. 2009) 3 22 46 64
- Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. (PMID: 18499658) Farina A. … Hurwitz J. (J. Biol. Chem. 2008) 3 4 22 64
- Associations of DNase IV polymorphisms with autoantibodies in patients with systemic lupus erythematosus. (PMID: 18417526) Kim I. … Bae S.C. (Rheumatology (Oxford) 2008) 3 22 46 64
- Structural basis for recruitment of human flap endonuclease 1 to PCNA. (PMID: 15616578) Sakurai S. … Hakoshima T. (EMBO J. 2005) 3 4 22 64
Products for FEN1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
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- Custom Antibody ServicesOriGene Antibodies for FEN1
- AP06687PU-N
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- TA802774
- CF802774
- TA802762AM
- TA802762BM
- TA802762CM
- TA802762DM
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- TA802762FM
- TA802762GM
- TA802762HM
- TA802762JM
- TA802763AM
- TA802763BM
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Sources for FEN1 Gene
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