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Aliases for FEM1C Gene

Aliases for FEM1C Gene

  • Fem-1 Homolog C 2 3
  • Fem-1 Homolog C (C. Elegans) 2 5
  • FEM1-Gamma 3 4
  • EUROIMAGE686608 3
  • EUROIMAGE783647 3
  • KIAA1785 4
  • FEM1a 3
  • FEM1c 4

External Ids for FEM1C Gene

Previous GeneCards Identifiers for FEM1C Gene

  • GC05M114624
  • GC05M115264
  • GC05M114887
  • GC05M114932
  • GC05M114884
  • GC05M110038

Summaries for FEM1C Gene

GeneCards Summary for FEM1C Gene

FEM1C (Fem-1 Homolog C) is a Protein Coding gene. An important paralog of this gene is FEM1B.

UniProtKB/Swiss-Prot for FEM1C Gene

  • Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1C Gene

Genomics for FEM1C Gene

Regulatory Elements for FEM1C Gene

Enhancers for FEM1C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FEM1C on UCSC Golden Path with GeneCards custom track

Genomic Location for FEM1C Gene

115,520,908 bp from pter
115,544,894 bp from pter
23,987 bases
Minus strand

Genomic View for FEM1C Gene

Genes around FEM1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1C Gene

Proteins for FEM1C Gene

  • Protein details for FEM1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein fem-1 homolog C
    Protein Accession:
    Secondary Accessions:
    • B2RE47
    • Q8N3V8
    • Q9H704
    • Q9NPL6
    • Q9NPL9

    Protein attributes for FEM1C Gene

    617 amino acids
    Molecular mass:
    68673 Da
    Quaternary structure:
    • Component of some E3 ubiquitin-protein ligase complex.
    • Sequence=BAB15096.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FEM1C Gene

Proteomics data for FEM1C Gene at MOPED

Post-translational modifications for FEM1C Gene

  • Ubiquitination at Lys 267
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FEM1C

No data available for DME Specific Peptides for FEM1C Gene

Domains & Families for FEM1C Gene

Gene Families for FEM1C Gene

Protein Domains for FEM1C Gene

Suggested Antigen Peptide Sequences for FEM1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fem-1 family.
  • Contains 9 ANK repeats.
  • Belongs to the fem-1 family.
  • Contains 9 ANK repeats.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with FEM1C: view

Function for FEM1C Gene

Molecular function for FEM1C Gene

UniProtKB/Swiss-Prot Function:
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.
genes like me logo Genes that share phenotypes with FEM1C: view

Animal Model Products

miRNA for FEM1C Gene

miRTarBase miRNAs that target FEM1C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEM1C Gene

Localization for FEM1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1C Gene


Subcellular locations from

Jensen Localization Image for FEM1C Gene COMPARTMENTS Subcellular localization image for FEM1C gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FEM1C: view

Pathways & Interactions for FEM1C Gene

SuperPathways for FEM1C Gene

No Data Available

UniProtKB/Swiss-Prot Q96JP0-FEM1C_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1C Gene


No data available for Pathways by source and SIGNOR curated interactions for FEM1C Gene

Drugs & Compounds for FEM1C Gene

No Compound Related Data Available

Transcripts for FEM1C Gene

mRNA/cDNA for FEM1C Gene

Unigene Clusters for FEM1C Gene

Fem-1 homolog c (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2: -

Relevant External Links for FEM1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEM1C Gene

mRNA expression in normal human tissues for FEM1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FEM1C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FEM1C Gene

SOURCE GeneReport for Unigene cluster for FEM1C Gene Hs.47367

mRNA Expression by UniProt/SwissProt for FEM1C Gene

Tissue specificity: Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.
genes like me logo Genes that share expression patterns with FEM1C: view

Protein tissue co-expression partners for FEM1C Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FEM1C Gene

Orthologs for FEM1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FEM1C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC541180 35
  • 95.25 (n)
  • 99.84 (a)
FEM1C 36
  • 100 (a)
(Canis familiaris)
Mammalia FEM1C 35
  • 93.63 (n)
  • 99.68 (a)
FEM1C 36
  • 96 (a)
(Mus musculus)
Mammalia Fem1c 35
  • 92.38 (n)
  • 99.51 (a)
Fem1c 16
Fem1c 36
  • 100 (a)
(Pan troglodytes)
Mammalia FEM1C 35
  • 99.78 (n)
  • 100 (a)
FEM1C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fem1c 35
  • 93.08 (n)
  • 99.68 (a)
(Monodelphis domestica)
Mammalia FEM1C 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia FEM1C 36
  • 86 (a)
(Gallus gallus)
Aves FEM1C 35
  • 82.39 (n)
  • 90.6 (a)
FEM1C 36
  • 91 (a)
(Anolis carolinensis)
Reptilia FEM1C 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fem1c 35
  • 76.77 (n)
  • 89.63 (a)
Str.15002 35
(Danio rerio)
Actinopterygii fem1c 35
  • 66.5 (n)
  • 79.35 (a)
fem1c 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003839 35
  • 53.31 (n)
  • 55.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6966 35
  • 54.04 (n)
  • 55.52 (a)
CG6966 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea fem-1 35
  • 49.97 (n)
  • 40.37 (a)
fem-1 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAR1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for FEM1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEM1C Gene

Gene Tree for FEM1C (if available)
Gene Tree for FEM1C (if available)

Paralogs for FEM1C Gene

Paralogs for FEM1C Gene

(2) SIMAP similar genes for FEM1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEM1C: view

Variants for FEM1C Gene

Sequence variations from dbSNP and Humsavar for FEM1C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_039810 A breast cancer sample
VAR_039811 A breast cancer sample
rs3727 -- 115,521,013(+) TCTTT(C/T)GAAAA utr-variant-3-prime
rs813761 -- 115,536,030(+) agaaa(A/G)gagat intron-variant
rs166281 -- 115,529,745(-) TTAGA(A/C)CACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEM1C Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV Gain 17160897
esv269779 CNV Insertion 20981092

Variation tolerance for FEM1C Gene

Residual Variation Intolerance Score: 9.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEM1C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1C Gene

Disorders for FEM1C Gene

Relevant External Links for FEM1C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FEM1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEM1C Gene

Publications for FEM1C Gene

  1. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. (PMID: 14527725) Ventura-Holman T. … Maher J.F. (Gene 2003) 2 3 4 23 67
  2. Identification of human FEM1A, the ortholog of a C. elegans sex- differentiation gene. (PMID: 11733146) Krakow D. … Cohn D.H. (Gene 2001) 2 3 23
  3. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PMID: 18757445) Goodarzi M.O. … Azziz R. (Hum. Reprod. 2008) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for FEM1C Gene

Sources for FEM1C Gene