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Aliases for FEM1C Gene

Aliases for FEM1C Gene

  • Fem-1 Homolog C 2 3 5
  • FEM1-Gamma 3 4
  • Fem-1 Homolog C (C. Elegans) 2
  • Protein Fem-1 Homolog C 3
  • EUROIMAGE686608 3
  • EUROIMAGE783647 3
  • KIAA1785 4
  • FEM1a 3
  • FEM1c 4

External Ids for FEM1C Gene

Previous GeneCards Identifiers for FEM1C Gene

  • GC05M114624
  • GC05M115264
  • GC05M114887
  • GC05M114932
  • GC05M114884
  • GC05M110038

Summaries for FEM1C Gene

GeneCards Summary for FEM1C Gene

FEM1C (Fem-1 Homolog C) is a Protein Coding gene. An important paralog of this gene is FEM1A.

UniProtKB/Swiss-Prot for FEM1C Gene

  • Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1C Gene

Genomics for FEM1C Gene

Regulatory Elements for FEM1C Gene

Enhancers for FEM1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F115459 1.4 FANTOM5 Ensembl ENCODE 19.7 +83.8 83810 4.0 KLF1 TAF1 JUN SIN3A CBX5 EED FOS CREM MAFK STAT1 TICAM2 FEM1C PGGT1B GC05M115471 AK3P4
GH05F115418 1.2 FANTOM5 Ensembl ENCODE 13.4 +125.5 125522 2.6 STAT1 ZNF133 JUN CEBPB MAX EP300 ZFHX2 JUND STAT3 ZNF143 TICAM2 FEM1C PGGT1B AK3P4 GC05M115471
GH05F115574 0.9 Ensembl ENCODE 11.9 -29.9 -29907 0.4 CTCF ZNF362 ZNF654 MTA2 JUNB MAFG ZNF384 REST ZNF2 RAD21 LOC101927100 FEM1C TICAM2 CCDC112 TMED7-TICAM2 TMED7 GC05P115575
GH05F115541 1.4 FANTOM5 ENCODE 5.8 +1.4 1410 4.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ENSG00000271918 ENSG00000250015 SEMA6A-AS1 ATG12 LOC101927078 HMGN2P27 CCT5P1 PGGT1B LOC101927100 TICAM2
GH05F115413 1.3 FANTOM5 Ensembl ENCODE 5.5 +129.8 129818 2.5 SOX13 KLF1 MXI1 JUN SIN3A KLF17 MAX RAD21 ZFHX2 SCRT2 FEM1C AK3P4 GC05M115471
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FEM1C on UCSC Golden Path with GeneCards custom track

Genomic Location for FEM1C Gene

115,520,908 bp from pter
115,544,894 bp from pter
23,987 bases
Minus strand

Genomic View for FEM1C Gene

Genes around FEM1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1C Gene

Proteins for FEM1C Gene

  • Protein details for FEM1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein fem-1 homolog C
    Protein Accession:
    Secondary Accessions:
    • B2RE47
    • Q8N3V8
    • Q9H704
    • Q9NPL6
    • Q9NPL9

    Protein attributes for FEM1C Gene

    617 amino acids
    Molecular mass:
    68673 Da
    Quaternary structure:
    • Component of some E3 ubiquitin-protein ligase complex.
    • Sequence=BAB15096.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FEM1C Gene

Post-translational modifications for FEM1C Gene

  • Ubiquitination at Lys 267
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEM1C Gene

Domains & Families for FEM1C Gene

Gene Families for FEM1C Gene

Protein Domains for FEM1C Gene

Suggested Antigen Peptide Sequences for FEM1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fem-1 family.
  • Contains 9 ANK repeats.
  • Belongs to the fem-1 family.
  • Contains 9 ANK repeats.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with FEM1C: view

Function for FEM1C Gene

Molecular function for FEM1C Gene

UniProtKB/Swiss-Prot Function:
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.

Gene Ontology (GO) - Molecular Function for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FEM1C: view
genes like me logo Genes that share phenotypes with FEM1C: view

Animal Model Products

miRNA for FEM1C Gene

miRTarBase miRNAs that target FEM1C

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEM1C Gene

Localization for FEM1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1C Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEM1C gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FEM1C: view

Pathways & Interactions for FEM1C Gene

SuperPathways for FEM1C Gene

No Data Available

UniProtKB/Swiss-Prot Q96JP0-FEM1C_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FEM1C: view

No data available for Pathways by source and SIGNOR curated interactions for FEM1C Gene

Transcripts for FEM1C Gene

mRNA/cDNA for FEM1C Gene

Unigene Clusters for FEM1C Gene

Fem-1 homolog c (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2: -

Relevant External Links for FEM1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEM1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FEM1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FEM1C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEM1C Gene

Protein tissue co-expression partners for FEM1C Gene

NURSA nuclear receptor signaling pathways regulating expression of FEM1C Gene:


SOURCE GeneReport for Unigene cluster for FEM1C Gene:


mRNA Expression by UniProt/SwissProt for FEM1C Gene:

Tissue specificity: Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.
genes like me logo Genes that share expression patterns with FEM1C: view

Primer Products

No data available for mRNA differential expression in normal tissues for FEM1C Gene

Orthologs for FEM1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FEM1C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FEM1C 35
  • 100 (a)
LOC541180 34
  • 95.25 (n)
(Pan troglodytes)
Mammalia FEM1C 34 35
  • 99.78 (n)
(Monodelphis domestica)
Mammalia FEM1C 35
  • 95 (a)
(Canis familiaris)
Mammalia FEM1C 34 35
  • 93.63 (n)
(Rattus norvegicus)
Mammalia Fem1c 34
  • 93.08 (n)
(Mus musculus)
Mammalia Fem1c 34 16 35
  • 92.38 (n)
(Ornithorhynchus anatinus)
Mammalia FEM1C 35
  • 86 (a)
(Gallus gallus)
Aves FEM1C 34 35
  • 82.39 (n)
(Anolis carolinensis)
Reptilia FEM1C 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fem1c 34
  • 76.77 (n)
Str.15002 34
(Danio rerio)
Actinopterygii fem1c 34 35
  • 66.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6966 34 35
  • 54.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003839 34
  • 53.31 (n)
(Caenorhabditis elegans)
Secernentea fem-1 34 35
  • 49.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAR1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
Species where no ortholog for FEM1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEM1C Gene

Gene Tree for FEM1C (if available)
Gene Tree for FEM1C (if available)

Paralogs for FEM1C Gene

Paralogs for FEM1C Gene

(2) SIMAP similar genes for FEM1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEM1C: view

Variants for FEM1C Gene

Sequence variations from dbSNP and Humsavar for FEM1C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_039810 A breast cancer sample
VAR_039811 A breast cancer sample
rs10043328 -- 115,543,820(+) CCCCC(A/C)CCCCC intron-variant
rs10053572 -- 115,541,847(+) ACATA(C/G)ACAAG intron-variant
rs10077232 -- 115,530,041(+) acatt(A/T)aaaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEM1C Gene

Variant ID Type Subtype PubMed ID
esv3444399 CNV insertion 20981092
nsv830455 CNV gain 17160897
nsv950116 CNV duplication 24416366

Variation tolerance for FEM1C Gene

Residual Variation Intolerance Score: 9.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEM1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1C Gene

Disorders for FEM1C Gene

Relevant External Links for FEM1C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FEM1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEM1C Gene

Publications for FEM1C Gene

  1. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. (PMID: 14527725) Ventura-Holman T. … Maher J.F. (Gene 2003) 2 3 4 22 64
  2. Identification of human FEM1A, the ortholog of a C. elegans sex- differentiation gene. (PMID: 11733146) Krakow D. … Cohn D.H. (Gene 2001) 2 3 4 22 64
  3. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PMID: 18757445) Goodarzi M.O. … Azziz R. (Hum. Reprod. 2008) 3 22 46 64
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FEM1C Gene

Sources for FEM1C Gene

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