Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FEM1C Gene

protein-coding   GIFtS: 57
GCID: GC05M114884

Fem-1 Homolog C (C. Elegans)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fem-1 Homolog C (C. Elegans)1 2     FEM1A2
FEM1-gamma2 3     Protein Fem-1 Homolog C2
EUROIMAGE6866082     FEM1c3
EUROIMAGE7836472     KIAA17853

External Ids:    HGNC: 169331   Entrez Gene: 569292   Ensembl: ENSG000001457807   OMIM: 6087675   UniProtKB: Q96JP03   

Export aliases for FEM1C gene to outside databases

Previous GC identifers: GC05M114624 GC05M115264 GC05M114887 GC05M114932 GC05M110038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for FEM1C Gene:
FEM1C (fem-1 homolog c (C. elegans)) is a protein-coding gene. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0
Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate
recognition subunit (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FEM1C gene promoter:
         FOXO3   CUTL1   Cdc5   HNF-3beta   YY1   Evi-1   FOXO3b   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFEM1C promoter sequence
   Search Chromatin IP Primers for FEM1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FEM1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22

FEM1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEM1C gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114884:  view genomic region     (about GC identifiers)

Start:
114,856,608 bp from pter      End:
114,880,591 bp from pter
Size:
23,984 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0 (See protein sequence)
Recommended Name: Protein fem-1 homolog C  
Size: 617 amino acids; 68673 Da
Subunit: Component of some E3 ubiquitin-protein ligase complex (By similarity)
Caution: Was initially thought to be the ortholog of mouse FEM1A (PubMed:11733146)
Sequence caution: Sequence=BAB15096.1; Type=Erroneous initiation;
Secondary accessions: B2RE47 Q8N3V8 Q9H704 Q9NPL6 Q9NPL9

Explore the universe of human proteins at neXtProt for FEM1C: NX_Q96JP0

Explore proteomics data for FEM1C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys267
  • Modification sites at PhosphoSitePlus

  • See FEM1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064562.1  
    ENSEMBL proteins: 
     ENSP00000274457  

    FEM1C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FEM1C
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FEM1C
    GenScript Custom Purified and Recombinant Proteins Services for FEM1C
    Novus Biologicals FEM1C Protein
    Novus Biologicals FEM1C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FEM1C

     
    Search eBioscience for Proteins for FEM1C 

     
    antibodies-online proteins for FEM1C (3 products) 

     
    antibodies-online peptides for FEM1C

    FEM1C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FEM1C
    Novus Biologicals FEM1C Antibodies
    Abcam antibodies for FEM1C
    Cloud-Clone Corp. Antibodies for FEM1C
    ThermoFisher Antibodies for FEM1C
    antibodies-online antibodies for FEM1C (19 products) 

    FEM1C Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FEM1C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FEM1C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FEM1C
    Cloud-Clone Corp. CLIAs for FEM1C
    Search eBioscience for ELISAs for FEM1C 
    antibodies-online kits for FEM1C (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96JP0

    ProtoNet protein and cluster: Q96JP0

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0
    Similarity: Belongs to the fem-1 family
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 2 TPR repeats


    Find genes that share domains with FEM1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEM1C_HUMAN, Q96JP0
    Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate
    recognition subunit (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FEM1C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FEM1C:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fem1c):
     nervous system  reproductive system 

    Find genes that share phenotypes with FEM1C           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FEM1C

    miRNA
    Products:
        
    miRTarBase miRNAs that target FEM1C:
    hsa-mir-18a-5p (MIRT031336), hsa-mir-93-5p (MIRT028176), hsa-mir-103a-3p (MIRT027153), hsa-mir-16-5p (MIRT031848)

    Block miRNA regulation of human, mouse, rat FEM1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FEM1C (see all 68):
    hsa-miR-520e hsa-miR-106a hsa-miR-208b hsa-miR-93 hsa-miR-520b hsa-miR-20a hsa-miR-186* hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidFEM1C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FEM1C
    Predesigned siRNA for gene silencing in human, mouse, rat FEM1C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FEM1C

    Clone
    Products:
         
    OriGene clones in human, mouse for FEM1C (see all 6)
    OriGene ORF clones in mouse, rat for FEM1C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FEM1C (NM_020177)
    Sino Biological Human cDNA Clone for FEM1C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEM1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEM1C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FEM1C
    Browse ESI BIO Cell Lines and PureStem Progenitors for FEM1C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FEM1C_HUMAN, Q96JP0: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with FEM1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




    UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FEM1C
    Interactions:

        Search GeneGlobe Interaction Network for FEM1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FEM1C (Q96JP03 ENSP000002744574) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEAL1Q151703, ENSP000003617074I2D: score=2 STRING: ENSP00000361707
    FBXW7Q969H03, ENSP000002817084I2D: score=1 STRING: ENSP00000281708
    CUL2Q136173I2D: score=1 
    PPM1FP495933I2D: score=1 
    TCEB1Q153693I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with FEM1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FEM1C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FEM1C gene: 
    NM_020177.2  

    Unigene Cluster for FEM1C:

    Fem-1 homolog c (C. elegans)
    Hs.47367  [show with all ESTs]
    Unigene Representative Sequence: NM_020177
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274457(uc003krb.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FEM1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FEM1C (see all 68):
    hsa-miR-520e hsa-miR-106a hsa-miR-208b hsa-miR-93 hsa-miR-520b hsa-miR-20a hsa-miR-186* hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidFEM1C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FEM1C
    Predesigned siRNA for gene silencing in human, mouse, rat FEM1C
    Clone
    Products:
         
    OriGene clones in human, mouse for FEM1C (see all 6)
    OriGene ORF clones in mouse, rat for FEM1C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FEM1C (NM_020177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FEM1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEM1C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FEM1C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FEM1C
      QuantiTect SYBR Green Assays in human, mouse, rat FEM1C
      QuantiFast Probe-based Assays in human, mouse, rat FEM1C

    Additional mRNA sequence: 

    AB058688.1 AF391093.1 AK025265.1 AK315803.1 AL050087.1 AL110246.1 AL365409.1 AL365415.1 
    AL831817.1 AY249188.1 BC028369.2 BC098385.1 

    4 DOTS entries:

    DT.209778  DT.100022681  DT.100736405  DT.120813046 

    Selected AceView cDNA sequences (see all 93):

    NM_020177 AL365409 BQ573804 AL050087 AI753510 AB058688 CA774558 Z40725 
    AL365415 AL831817 AA446691 AK025265 AY249188 BQ025839 CA941636 Z44988 
    F07742 AL110246 Z44937 CB154094 AW576227 BP335508 BG057303 AF391093 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FEM1C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -                           
    SP2:              -                           
    SP3:                                          


    ECgene alternative splicing isoforms for FEM1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FEM1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGTTGCA
    FEM1C Expression
    About this image

    FEM1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FEM1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.47367

    UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0
    Tissue specificity: Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis.
    Expressed at lower levels in other tissues, including cartilage

        Custom PCR Arrays for FEM1C
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FEM1C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FEM1C
    QuantiTect SYBR Green Assays in human, mouse, rat FEM1C
    QuantiFast Probe-based Assays in human, mouse, rat FEM1C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FEM1C gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fem1c1 , 5 fem-1 homolog c (C.elegans)1, 5 92.38(n)1
    99.51(a)1
      18 (24.62 cM)5
    2402631  NM_173423.41  NP_775599.11 
     465017465 
    chicken
    (Gallus gallus)
    Aves FEM1C1 fem-1 homolog c (C. elegans) 82.39(n)
    90.6(a)
      431262  XM_428816.4  XP_428816.3 
    lizard
    (Anolis carolinensis)
    Reptilia FEM1C6
    fem-1 homolog c (C. elegans)
    94(a)
    1 ↔ 1
    GL343193.1(8272090-8282207)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.150022 Transcribed sequence with moderate similarity to protein more 79.06(n)    BX715992.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fem1c1 fem-1 homolog c (C.elegans) 66.5(n)
    79.35(a)
      378965  NM_198145.2  NP_937788.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69661 CG6966 54.04(n)
    55.52(a)
      41816  NM_001104326.1  NP_001097796.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fem-11 fem-1 49.97(n)
    40.37(a)
      177335  NM_068423.5  NP_500824.1 


    ENSEMBL Gene Tree for FEM1C (if available)
    TreeFam Gene Tree for FEM1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FEM1C gene
    TANC22  ANKS32  ANKRD172  ANKRD292  FEM1A2  ANKHD12  FANK12  KIDINS2202  
    ANKHD1-EIF4EBP32  FEM1B2  TANC12  ANKS62  
    2 SIMAP similar genes for FEM1C using alignment to 1 protein entry:     FEM1C_HUMAN:
    FEM1A    FEM1B

    Find genes that share paralogs with FEM1C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FEM1C (see all 488)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0398104
    A breast cancer sample4--see VAR_0398102 D N mis40--------
    VAR_0398114
    A breast cancer sample4--see VAR_0398112 D N mis40--------
    rs1171740941,2
    C,F--114856293(+) TCATAA/GTAATA 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs2020305851,2
    C--114856298(+) ATAATA/GTATTT 1 -- ds50010--------
    rs77120261,2
    C,F,A,H--114856307(+) TTATGA/GTATAC 1 -- ds500117Minor allele frequency- G:0.13NS EA NA WA CSA 2216
    rs751673041,2
    C,F--114856325(+) CACAGC/TAAACC 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1828457611,2
    --114856326(+) ACAGCA/TAACCA 1 -- ds50010--------
    rs1414358381,2
    C--114856393(+) TCCCCA/GTATCT 1 -- ds50010--------
    rs1878761531,2
    --114856434(+) ATTTAG/TAATAA 1 -- ds50010--------
    rs759006211,2
    C,F--114856475(+) ATTAAC/TAATAA 1 -- ds50013Minor allele frequency- T:0.06CSA WA NA 240

    HapMap Linkage Disequilibrium report for FEM1C (114856608 - 114880591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FEM1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269779CNV Insertion20981092
    nsv830455CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FEM1C
    DNA2.0 Custom Variant and Variant Library Synthesis for FEM1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608767    OMIM disorders: --


    Find genes that share disorders with FEM1C           About GenesLikeMe

    Genetic Association Database (GAD): FEM1C
    Human Genome Epidemiology (HuGE) Navigator: FEM1C (1 document)

    Export disorders for FEM1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FEM1C gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FEM1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. (PubMed id 14527725)1, 2, 3, 9 Ventura-Holman T.... Maher J.F. (Gene 2003)
    2. Identification of human FEM1A, the ortholog of a C. elegans sex- differentiation gene. (PubMed id 11733146)1, 2, 3, 9 Krakow D.... Cohn D.H. (Gene 2001)
    3. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PubMed id 18757445)1, 4, 9 Goodarzi M.O....Azziz R. (Hum. Reprod. 2008)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 56929 HGNC: 16933 AceView: FEM1C Ensembl:ENSG00000145780 euGenes: HUgn56929
    ECgene: FEM1C H-InvDB: FEM1C

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1785

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FEM1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FEM1C gene:
    Search GeneIP for patents involving FEM1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FEM1C  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FEM1C  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FEM1C  
     OriGene qSTAR qPCR primer pairs in human, mouse for FEM1C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FEM1C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FEM1C   OriGene Custom Protein Services for FEM1C  

     
     
     Block miRNA regulation of human, mouse, rat FEM1C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FEM1C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FEM1C Predesigned siRNA for gene silencing in human, mouse, rat FEM1C
     QuantiFast Probe-based Assays in human, mouse, rat FEM1C QuantiTect SYBR Green Assays in human, mouse, rat FEM1C
     Custom PCR Arrays for FEM1C Search Chromatin IP Primers for FEM1C
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FEM1C  Search GeneGlobe Interaction Network for FEM1C
     Regulatory tfbs in FEM1C promoter
     GenScript Custom Purified and Recombinant Proteins Services for FEM1C GenScript cDNA clones with any tag delivered in your preferred vector for FEM1C
     GenScript Custom Assay Services for FEM1C GenScript Custom overexpressing Cell Line Services for FEM1C
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FEM1C
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FEM1C
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FEM1C antibodies
     FEM1C proteins
     FEM1C lysates
     Antibodies for FEM1C
     See all of Abcam's Antibodies, Kits and Proteins for FEM1C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FEM1C
     Antibodies for FEM1C
     ELISAs for FEM1C
     CLIAs for FEM1C



     Browse ESI BIO Cell Lines and PureStem Progenitors for FEM1C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1C
     SwitchGear 3'UTR luciferase reporter plasmids for FEM1C
     SwitchGear Promoter luciferase reporter plasmids for FEM1C
     ThermoFisher Antibodies for FEM1C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEM1C
     Browse compounds at ApexBio
     Search Addgene for plasmids for FEM1C
      Search eBioscience for proteins for FEM1C
      Search eBioscience for elisas for FEM1C
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FEM1C
     antibodies-online antibodies for FEM1C (19 products)
     antibodies-online kits for FEM1C (6 products)
     antibodies-online peptides for FEM1C
     antibodies-online proteins for FEM1C (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FEM1C gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4