FEM1C Gene
protein-coding GIFtS: 52
GCID: GC05M114884
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|
fem-1 homolog c (C. elegans)
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Aliases
for FEM1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fem-1 Homolog C (C. Elegans)1 2 | | KIAA17851 3 | | EUROIMAGE6866081 2 | | FEM1-Gamma1 | | EUROIMAGE7836471 2 | | Protein Fem-1 Homolog C2 | | FEM1A1 2 | | FEM1c3 |
Export aliases for FEM1C gene to outside databasesPrevious GC identifers: GC05M114624 GC05M115264 GC05M114887 GC05M114932 GC05M110038 |
Summaries
for FEM1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognitionsubunit (By similarity)
|
Genomic Views
for FEM1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FEM1C gene promoter:
FOXO3 CUTL1 Cdc5 HNF-3beta YY1 Evi-1 FOXO3b FOXJ2 (long isoform) FOXO3a FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FEM1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEM1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q22 Ensembl cytogenetic band: 5q22.3 HGNC cytogenetic band: 5q22FEM1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M114884: view genomic region
(about GC identifiers)
Start:
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114,856,608 bp from pter |
End:
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114,880,591 bp from pter |
Size:
|
23,984 bases |
Orientation:
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minus strand |
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Proteins
for FEM1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0 (See
protein sequence)Recommended Name: Protein fem-1 homolog C Size: 617 amino acids; 68673 Da
Subunit: Component of some E3 ubiquitin-protein ligase complex (By similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Was initially thought to be the ortholog of mouse FEM1A (PubMed:11733146)
Sequence caution: Sequence=BAB15096.1; Type=Erroneous initiation;
Secondary accessions: B2RE47 Q8N3V8 Q9H704 Q9NPL6 Q9NPL9Explore the universe of human proteins at neXtProt for FEM1C: NX_Q96JP0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JP0
FEM1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064562.1
ENSEMBL proteins: ENSP00000274457
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
FEM1C for ontologies About GeneDecksing
FEM1C Antibody Products:
Assay Products for FEM1C: |
Protein
Domains /
Families
for FEM1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FEM1C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96JP0ProtoNet protein and cluster: Q96JP0 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0Similarity: Belongs to the fem-1 familySimilarity: Contains 9 ANK repeatsSimilarity: Contains 2 TPR repeats |
Function
for FEM1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognitionsubunit (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1C |
1 GenomeRNAi human phenotype for FEM1C:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fem1c):
FEM1C for phenotypes About GeneDecksing
|
Pathways & Interactions
for FEM1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FEM1C
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for FEM1C (Q96JP03 ENSP000002744574) via UniProtKB, MINT, STRING, and/or I2D (see all 8) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
FEM1C for ontologies About GeneDecksing
|
Drugs & Compounds
for FEM1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FEM1C
Search CenterWatch for drugs/clinical trials and news about FEM1C
|
Transcripts
for FEM1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FEM1C gene: NM_020177.2 Unigene Cluster for FEM1C: Fem-1 homolog c (C. elegans) Hs.47367 [show with all ESTs]Unigene Representative Sequence: NM_0201771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000274457(uc003krb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FEM1C (NM_020177) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FEM1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEM1C |
Additional cDNA sequence: AB058688.1 AF391093.1 AK025265.1 AK315803.1 AL050087.1 AL110246.1 AL365409.1 AL365415.1 AL831817.1 AY249188.1 BC028369.2 BC098385.1 4 DOTS entries: DT.209778 DT.100022681 DT.100736405 DT.120813046 24/93 AceView cDNA sequences (see all 93): BQ422068 AI753510 CA941636 CA774558 F07742 BP335508 AY249188 AL831817 AL365415 BQ025839 AL050087 Z44988 CB154094 AL110246 AW576227 BG057303 AF391093 AK025265 BF445605 BQ573804 AA446691 AB058688 AA814586 NM_020177
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FEM1C About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 |
|---|
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| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FEM1C
|
Expression
for FEM1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FEM1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGGTTGCA
About this image
See FEM1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FEM1C
SOURCE GeneReport for Unigene cluster: Hs.47367
UniProtKB/Swiss-Prot: FEM1C_HUMAN, Q96JP0Tissue specificity: Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressedat lower levels in other tissues, including cartilage
SABiosciences Custom PCR Arrays for FEM1C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FEM1C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FEM1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FEM1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEM1C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1C |
Orthologs
for FEM1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FEM1C gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for FEM1C (if available)
TreeFam Gene Tree for FEM1C (if available) |
Paralogs
for FEM1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FEM1C gene
- ANKRD292 FEM1B2 FEM1A2 KIDINS2202
2 SIMAP similar genes for FEM1C using alignment to 1 protein entry: FEM1C_HUMAN:FEM1A FEM1B
FEM1C for paralogs About GeneDecksing
|
Genomic Variants
for FEM1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FEM1C (114856608 - 114880591 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FEM1C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FEM1C |
|
Disorders
/ Diseases
for FEM1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FEM1C for disorders About GeneDecksing
OMIM gene information: 608767
OMIM disorders: --
1  disease for FEM1C: About MalaCardspolycystic ovary syndrome
Human Genome Epidemiology (HuGE) Navigator: FEM1C (1 document)
Export disorders for FEM1C gene to outside databases
|
Publications
for FEM1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FEM1C gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FEM1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. (PubMed id 14527725)1, 2, 3, 9 Ventura-Holman T.... Maher J.F. (2003)
- Identification of human FEM1A, the ortholog of a C. elegans sex- differentiation gene. (PubMed id 11733146)1, 2, 3, 9 Krakow D.... Cohn D.H. (2001)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
- FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PubMed id 18757445)1, 9 Goodarzi M.O....Azziz R. (2008)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for FEM1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FEM1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FEM1C gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FEM1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FEM1C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FEM1C gene:
Search GeneIP for patents involving FEM1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FEM1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for FEM1C | | OriGene Custom Protein Services for FEM1C | | | OriGene Custom Immunoassay Development | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1C |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEM1C |
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