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FEM1B Gene

protein-coding   GIFtS: 56
GCID: GC15P068570

Fem-1 Homolog B (C. Elegans)

(Previous name: FEM-1 (C. elegans) homolog b)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fem-1 Homolog B (C. Elegans)1 2     F1A-ALPHA2
Fem-1-Like Death Receptor-Binding Protein Alpha2 3     FEM-1-Like Death Receptor Binding Protein2
Fem-1-Like In Apoptotic Pathway Protein Alpha2 3     Protein Fem-1 Homolog B2
F1AA2 3     F1A-alpha3
FEM1-beta2 3     FEM1b3
FEM-1 (C. Elegans) Homolog B1     KIAA03963

External Ids:    HGNC: 36491   Entrez Gene: 101162   Ensembl: ENSG000001690187   OMIM: 6135395   UniProtKB: Q9UK733   

Export aliases for FEM1B gene to outside databases

Previous GC identifers: GC15P064410 GC15P061668 GC15P066148 GC15P066285 GC15P066357 GC15P045400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FEM1B Gene:
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and
plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication
stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. (provided by RefSeq, Aug
2013)

GeneCards Summary for FEM1B Gene:
FEM1B (fem-1 homolog b (C. elegans)) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and death receptor binding. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition
subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also
involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication
stress-induced signaling that leads to the activation of CHEK1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FEM1B gene promoter:
         PPAR-alpha   Bach1   AML1a   p53   Pax-5   Nkx2-2   MRF-2   GATA-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FEM1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FEM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22

FEM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEM1B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P068570:  view genomic region     (about GC identifiers)

Start:
68,570,141 bp from pter      End:
68,588,203 bp from pter
Size:
18,063 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73 (See protein sequence)
Recommended Name: Protein fem-1 homolog B  
Size: 627 amino acids; 70264 Da
Subunit: Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1,
TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and
TNFRSF1A. Interacts with CHEK1
Secondary accessions: O43146

Explore the universe of human proteins at neXtProt for FEM1B: NX_Q9UK73

Explore proteomics data for FEM1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys469
  • Modification sites at PhosphoSitePlus

  • See FEM1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056137.1  
    ENSEMBL proteins: 
     ENSP00000307298   ENSP00000457002   ENSP00000457342   ENSP00000456968  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9UK73

    ProtoNet protein and cluster: Q9UK73

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Similarity: Belongs to the fem-1 family
    Similarity: Contains 8 ANK repeats
    Similarity: Contains 1 TPR repeat


    Find genes that share domains with FEM1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEM1B_HUMAN, Q9UK73
    Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition
    subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also
    involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication
    stress-induced signaling that leads to the activation of CHEK1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP15601820
    GO:0005123death receptor binding NAS10623617
    GO:0005515protein binding IPI11559703
         
    Find genes that share ontologies with FEM1B           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fem1b):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with FEM1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FEM1B: Fem1btm1Jfma Fem1btm1Mms

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FEM1B_HUMAN, Q9UK73: Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after
    camptothecin (CPT) treatment. Associated with chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with FEM1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FEM1B: 

              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FEM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for FEM1B (Q9UK731, 2, 3 ENSP000003072984) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPM1FP495931, 2, 3, ENSP000002632124EBI-310482,EBI-719945 MINT-8215474 MINT-8215483 I2D: score=1 STRING: ENSP00000263212
    CUL2Q136173, ENSP000003638804I2D: score=2 STRING: ENSP00000363880
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    RBX1P628773, ENSP000002162254I2D: score=2 STRING: ENSP00000216225
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002070epithelial cell maturation ----
    GO:0006915apoptotic process NAS10623617
    GO:0016567protein ubiquitination ----
    GO:0051438regulation of ubiquitin-protein ligase activity IMP15601820
    GO:0060442branching involved in prostate gland morphogenesis IEA--

    Find genes that share ontologies with FEM1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FEM1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FEM1B gene: 
    NM_015322.4  

    Unigene Cluster for FEM1B:

    Fem-1 homolog b (C. elegans)
    Hs.362733  [show with all ESTs]
    Unigene Representative Sequence: AL833264
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306917(uc002arg.3) ENST00000570067 ENST00000566739 ENST00000566008

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    Additional mRNA sequence: 

    AB007856.2 AF178632.1 AF204883.1 AK098620.1 AK290167.1 AL833264.1 BC010122.2 BC014558.2 

    3 DOTS entries:

    DT.40269875  DT.100754756  DT.121025984 

    Selected AceView cDNA sequences (see all 247):

    BC010122 AA961254 BF112021 AI372871 CB157821 BI831081 W60202 BM829540 
    T16735 BE465637 AU130679 BX505251 NM_015322 AI377359 AF204883 AI281645 
    BM927893 CR612333 AA714667 AK098620 BF111324 AA954282 BM988065 BU676992 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FEM1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:        -     -     -                                       
    SP4:              -     -                                       
    SP5:                    -                                       


    ECgene alternative splicing isoforms for FEM1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FEM1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTTTGTT
    FEM1B Expression
    About this image


    FEM1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Larynx (Respiratory System)
    FEM1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FEM1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.362733

    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FEM1B: 
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FEM1B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fem1b1 , 5 feminization 1 homolog b (C. elegans)1, 5 90.38(n)1
    99.04(a)1
      9 (33.87 cM)5
    141551  NM_010193.41  NP_034323.11 
     627918325 
    chicken
    (Gallus gallus)
    Aves FEM1B1 fem-1 homolog b (C. elegans) 78.42(n)
    90.75(a)
      415559  NM_001030553.1  NP_001025724.1 
    lizard
    (Anolis carolinensis)
    Reptilia FEM1B6
    fem-1 homolog b (C. elegans)
    87(a)
    1 ↔ 1
    GL343467.1(770295-777471)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114862 Xenopus laevis transcribed sequence with moderate similarity more 77.84(n)    BJ062223.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fem1b1 fem-1 homolog b (C. elegans) 70.28(n)
    80.22(a)
      567119  XM_690410.5  XP_695502.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90253
    Fem-11
    Fem-11 45(a)3
    49.16(n)1
    42.09(a)1
      57A93
    373441  NM_137664.21  NP_611508.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C01H6.26
    Protein C01H6.2 (C01H6.2) mRNA, complete cds
    11(a)
    many ↔ many
    I(7204545-7207717) WBGene00007252


    ENSEMBL Gene Tree for FEM1B (if available)
    TreeFam Gene Tree for FEM1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FEM1B gene
    TANC22  ANKS32  ANKRD172  ANKRD292  FEM1A2  ANKHD12  FANK12  KIDINS2202  
    ANKHD1-EIF4EBP32  TANC12  ANKS62  FEM1C2  
    10 SIMAP similar genes for FEM1B using alignment to 3 protein entries:     FEM1B_HUMAN (see all proteins):
    ANKRD6    FEM1C    ANKRD29    FPGT-TNNI3K    PPP1R12C    RFXANK
    FEM1A    ANKRD12    TANC2    CASKIN2

    Find genes that share paralogs with FEM1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FEM1B (see all 342)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs1504522611,2
    --48620796(+) CTCCAC/GGTCAG 1 -- us2k10--------
    rs1151172641,2
    F--48620852(+) TGGTAG/AGGAGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs37598221,2
    C,F,H--48620879(+) GAGAGA/GCAGAG 1 -- us2k110Minor allele frequency- G:0.05EA NS NA WA 1280
    rs1440925221,2
    --48620936(+) CTTGCC/TGTATG 1 -- us2k10--------
    rs1870374051,2
    C--48621102(+) ACCAGC/TAGAAT 1 -- us2k10--------
    rs734278991,2
    C,F--48621109(+) GAATCT/ATACCT 1 -- us2k12Minor allele frequency- A:0.20WA 120
    rs1464470311,2
    C--48621196(+) AAGTGC/GGTAAA 1 -- us2k10--------
    rs1390493831,2
    --48621445(+) GAGTTC/TTTTGA 1 -- us2k10--------
    rs740198631,2
    C,F--48621540(+) GAGTTC/TATTCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1447456371,2
    --48621606(+) CCCTCC/TTTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FEM1B (68570141 - 68588203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FEM1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv752e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FEM1B
    DNA2.0 Custom Variant and Variant Library Synthesis for FEM1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 613539    OMIM disorders: --


    Find genes that share disorders with FEM1B           About GenesLikeMe

    Genetic Association Database (GAD): FEM1B
    Human Genome Epidemiology (HuGE) Navigator: FEM1B (3 documents)

    Export disorders for FEM1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FEM1B gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with FEM1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, organization, and expression of the human FEM1B gene. (PubMed id 10623617)1, 2, 3 Ventura-Holman T. and Maher J.F. (Biochem. Biophys. Res. Commun. 2000)
    2. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    3. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    4. Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. (PubMed id 19330022)1, 2 Sun T.P. and Shieh S.Y. (Oncogene 2009)
    5. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PubMed id 18757445)1, 4 Goodarzi M.O....Azziz R. (Hum. Reprod. 2008)
    6. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (Genes Dev. 2004)
    7. The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PubMed id 11559703)1, 2 Tan K.M.L.... Yu V.C. (J. Biol. Chem. 2001)
    8. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. (PubMed id 10542291)1, 2 Chan S.-L....Yu V.C. (J. Biol. Chem. 1999)
    9. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    10. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PubMed id 23377640)1 (Am J Psychiatry 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10116 HGNC: 3649 AceView: FEM1B Ensembl:ENSG00000169018 euGenes: HUgn10116
    ECgene: FEM1B H-InvDB: FEM1B

    (According to HUGE)
    About This Section

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    HUGE: KIAA0396

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FEM1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FEM1B gene:
    Search GeneIP for patents involving FEM1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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