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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FEM1B Gene

protein-coding   GIFtS: 55
GCID: GC15P068570

Fem-1 Homolog B (C. Elegans)

(Previous name: FEM-1 (C. elegans) homolog b)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fem-1 Homolog B (C. Elegans)1 2     F1A-ALPHA2
Fem-1-Like Death Receptor-Binding Protein Alpha2 3     FEM-1-Like Death Receptor Binding Protein2
Fem-1-Like In Apoptotic Pathway Protein Alpha2 3     Protein Fem-1 Homolog B2
F1AA2 3     F1A-alpha3
FEM1-beta2 3     FEM1b3
FEM-1 (C. Elegans) Homolog B1     KIAA03963

External Ids:    HGNC: 36491   Entrez Gene: 101162   Ensembl: ENSG000001690187   OMIM: 6135395   UniProtKB: Q9UK733   

Export aliases for FEM1B gene to outside databases

Previous GC identifers: GC15P064410 GC15P061668 GC15P066148 GC15P066285 GC15P066357 GC15P045400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FEM1B Gene:
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and
plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication
stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. (provided by RefSeq, Aug
2013)

GeneCards Summary for FEM1B Gene: 
FEM1B (fem-1 homolog b (C. elegans)) is a protein-coding gene. Diseases associated with FEM1B include polycystic ovary syndrome, and hypoxia. GO annotations related to this gene include ubiquitin-protein ligase activity and death receptor binding. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition
subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also
involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication
stress-induced signaling that leads to the activation of CHEK1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FEM1B gene promoter:
         PPAR-alpha   Bach1   AML1a   p53   Pax-5   Nkx2-2   MRF-2   GATA-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FEM1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22

FEM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEM1B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P068570:  view genomic region     (about GC identifiers)

Start:
68,570,141 bp from pter      End:
68,588,203 bp from pter
Size:
18,063 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73 (See protein sequence)
Recommended Name: Protein fem-1 homolog B  
Size: 627 amino acids; 70264 Da
Subunit: Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1,
TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and
TNFRSF1A. Interacts with CHEK1
Subcellular location: Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after
camptothecin (CPT) treatment. Associated with chromatin
Secondary accessions: O43146

Explore the universe of human proteins at neXtProt for FEM1B: NX_Q9UK73

Explore proteomics data for FEM1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK73

  • FEM1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FEM1B Protein Expression
    REFSEQ proteins: NP_056137.1  
    ENSEMBL proteins: 
     ENSP00000307298   ENSP00000457002   ENSP00000457342   ENSP00000456968  

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    Cloud-Clone Corp. Proteins for FEM1B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA19330022

    FEM1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9UK73

    ProtoNet protein and cluster: Q9UK73

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Similarity: Belongs to the fem-1 family
    Similarity: Contains 8 ANK repeats
    Similarity: Contains 1 TPR repeat


    FEM1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEM1B_HUMAN, Q9UK73
    Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition
    subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also
    involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication
    stress-induced signaling that leads to the activation of CHEK1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP15601820
    GO:0005123death receptor binding NAS10623617
    GO:0005515protein binding IPI11559703
         
    FEM1B for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fem1b):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    FEM1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FEM1B: Fem1btm1Jfma Fem1btm1Mms

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FEM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/22 Interacting proteins for FEM1B (Q9UK732, 3 ENSP000003072984) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPM1FP495932, 3, ENSP000002632124MINT-8215474 MINT-8215483 I2D: score=1 STRING: ENSP00000263212
    CUL2Q136173, ENSP000003638804I2D: score=2 STRING: ENSP00000363880
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    RBX1P628773, ENSP000002162254I2D: score=2 STRING: ENSP00000216225
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002070epithelial cell maturation ----
    GO:0006915apoptotic process NAS10623617
    GO:0016567protein ubiquitination ----
    GO:0051438regulation of ubiquitin-protein ligase activity IMP15601820
    GO:0060442branching involved in prostate gland morphogenesis IEA--

    FEM1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FEM1B

    Search CenterWatch for drugs/clinical trials and news about FEM1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FEM1B gene: 
    NM_015322.4  

    Unigene Cluster for FEM1B:

    Fem-1 homolog b (C. elegans)
    Hs.362733  [show with all ESTs]
    Unigene Representative Sequence: AL833264
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306917(uc002arg.3) ENST00000570067 ENST00000566739 ENST00000566008

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    Additional mRNA sequence: 

    AB007856.2 AF178632.1 AF204883.1 AK098620.1 AK290167.1 AL833264.1 BC010122.2 BC014558.2 

    3 DOTS entries:

    DT.40269875  DT.100754756  DT.121025984 

    24/247 AceView cDNA sequences (see all 247):

    BM454598 AI685927 AU130679 AF204883 BU190194 AA243257 BE018229 AA737787 
    AI206324 AI422232 BF222122 BU171519 CB157821 AA953992 BE465637 AL711376 
    BM927893 W60202 BM761900 BF111324 BI831081 BM829540 AI281645 AI271627 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FEM1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:        -     -     -                                       
    SP4:              -     -                                       
    SP5:                    -                                       


    ECgene alternative splicing isoforms for FEM1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FEM1B expression in normal human tissues (normalized intensities)      FEM1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTTTGTT
    FEM1B Expression
    About this image


    FEM1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Blood (Hematopoietic System)
             bone marrow cd34+   
     
     Larynx (Respiratory System)

    See FEM1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FEM1B

    SOURCE GeneReport for Unigene cluster: Hs.362733

    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including FEM1B: 
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FEM1B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fem1b1 , 5 feminization 1 homolog b (C. elegans)1, 5 90.43(n)1
    99.04(a)1
      9 (33.87 cM)5
    141551  NM_010193.41  NP_034323.11 
     627918325 
    chicken
    (Gallus gallus)
    Aves FEM1B1 fem-1 homolog b (C. elegans) 78.36(n)
    90.75(a)
      415559  NM_001030553.1  NP_001025724.1 
    lizard
    (Anolis carolinensis)
    Reptilia FEM1B6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343467.1(770295-777471)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114862 Xenopus laevis transcribed sequence with moderate similarity more 77.84(n)    BJ062223.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fem1b1 fem-1 homolog b (C. elegans) 70.33(n)
    80.22(a)
      567119  XM_690410.4  XP_695502.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90253
    Fem-11
    CG9025-PA1 45(a)3
    48.82(n)1
    41.45(a)1
      57A93
    373441  NM_137664.21  NP_611508.11 


    ENSEMBL Gene Tree for FEM1B (if available)
    TreeFam Gene Tree for FEM1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FEM1B gene
    TANC22  ANKS32  ANKRD172  ANKRD292  FEM1A2  ANKHD12  FANK12  KIDINS2202  
    RNASEL2  ANKHD1-EIF4EBP32  TANC12  ANKS62  FEM1C2  
    9 SIMAP similar genes for FEM1B using alignment to 3 protein entries:     FEM1B_HUMAN (see all proteins):
    ANKRD6    FEM1C    ANKRD29    PPP1R12C    RFXANK    FEM1A
    ANKRD12    TANC2    CASKIN2

    FEM1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/342 SNPs in FEM1B are shown (see all 342)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504522611,2
    --48620796(+) CTCCAC/GGTCAG 1 -- us2k10--------
    rs1151172641,2
    F--48620852(+) TGGTAG/AGGAGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs37598221,2
    C,F,H--48620879(+) GAGAGA/GCAGAG 1 -- us2k110Minor allele frequency- G:0.05EA NS NA WA 1280
    rs1440925221,2
    --48620936(+) CTTGCC/TGTATG 1 -- us2k10--------
    rs1870374051,2
    C--48621102(+) ACCAGC/TAGAAT 1 -- us2k10--------
    rs734278991,2
    C,F--48621109(+) GAATCT/ATACCT 1 -- us2k12Minor allele frequency- A:0.20WA 120
    rs1464470311,2
    C--48621196(+) AAGTGC/GGTAAA 1 -- us2k10--------
    rs1390493831,2
    --48621445(+) GAGTTC/TTTTGA 1 -- us2k10--------
    rs740198631,2
    C,F--48621540(+) GAGTTC/TATTCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1447456371,2
    --48621606(+) CCCTCC/TTTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FEM1B (68570141 - 68588203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FEM1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv752e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613539    OMIM disorders: --

    6 diseases for FEM1B:    About MalaCards
    polycystic ovary syndrome    hypoxia    atherosclerosis    colon cancer
    pancreatitis    prostatitis


    FEM1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FEM1B
    Human Genome Epidemiology (HuGE) Navigator: FEM1B (3 documents)

    Export disorders for FEM1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FEM1B gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with FEM1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, organization, and expression of the human FEM1B gene. (PubMed id 10623617)1, 2, 3 Ventura-Holman T. and Maher J.F. (2000)
    2. Family-based analysis of candidate genes for polycyst ic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (2010)
    3. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    4. Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. (PubMed id 19330022)1, 2 Sun T.P. and Shieh S.Y. (2009)
    5. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PubMed id 18757445)1, 4 Goodarzi M.O....Azziz R. (2008)
    6. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (2004)
    7. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PubMed id 11559703)1, 2 Tan K.M....Yu V.C. (2001)
    8. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. (PubMed id 10542291)1, 2 Chan S.-L....Yu V.C. (1999)
    9. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    10. Common genetic variation and antidepressant efficacy i n major depressive disorder: a meta-analysis of three genome-wide pharmacogeneti c studies. (PubMed id 23377640)1 (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10116 HGNC: 3649 AceView: FEM1B Ensembl:ENSG00000169018 euGenes: HUgn10116
    ECgene: FEM1B H-InvDB: FEM1B

    (According to HUGE)
    About This Section
    HUGE: KIAA0396

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FEM1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FEM1B gene:
    Search GeneIP for patents involving FEM1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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