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Aliases for FEM1B Gene

Aliases for FEM1B Gene

  • Fem-1 Homolog B 2 3 5
  • Fem-1-Like Death Receptor-Binding Protein Alpha 3 4
  • Fem-1-Like In Apoptotic Pathway Protein Alpha 3 4
  • F1A-ALPHA 3 4
  • FEM1-Beta 3 4
  • F1AA 3 4
  • FEM-1-Like Death Receptor Binding Protein 3
  • FEM-1 (C. Elegans) Homolog B 2
  • Fem-1 Homolog B (C. Elegans) 2
  • Protein Fem-1 Homolog B 3
  • KIAA0396 4
  • FEM1b 4

External Ids for FEM1B Gene

Previous GeneCards Identifiers for FEM1B Gene

  • GC15P064410
  • GC15P061668
  • GC15P066148
  • GC15P066285
  • GC15P066357
  • GC15P068570
  • GC15P045400

Summaries for FEM1B Gene

Entrez Gene Summary for FEM1B Gene

  • This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

GeneCards Summary for FEM1B Gene

FEM1B (Fem-1 Homolog B) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and death receptor binding. An important paralog of this gene is FEM1C.

UniProtKB/Swiss-Prot for FEM1B Gene

  • Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1B Gene

Genomics for FEM1B Gene

Regulatory Elements for FEM1B Gene

Enhancers for FEM1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F068298 1.2 Ensembl ENCODE 12.3 +22.4 22407 3.7 ELF3 RAD21 RARA YY1 ZNF121 SCRT2 CREM EGR2 THAP11 NFYC LOC105370872 FEM1B PIAS1 GC15M068298
GH15F068306 1.1 Ensembl ENCODE 12.3 +29.0 29045 1.2 KLF17 ZNF2 RAD21 RFX5 GLIS2 ZNF143 RCOR1 DEK MIXL1 EGR2 LOC105370872 FEM1B GC15M068298 ITGA11
GH15F068227 1.1 ENCODE 11.4 -48.5 -48514 3.6 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A ZNF207 ZNF143 IQCH-AS1 CLN6 FEM1B PIAS1 RNU6-1 LOC101929076 SKOR1 ENSG00000260007 CALML4
GH15F068303 1 Ensembl ENCODE 12.3 +27.2 27222 2.0 CTCF RFX1 TEAD4 KLF17 FEZF1 MNT ZFP69B ZNF664 ZFHX2 ZNF791 LOC105370872 FEM1B IQCH-AS1 PIAS1 GC15M068298 ITGA11
GH15F068256 0.9 ENCODE 12.4 -20.7 -20699 1.6 ELF3 ARID4B ZNF48 RAD21 YY1 THAP11 ZNF202 JUNB CEBPB REST FEM1B IQCH-AS1 CLN6 HMGN2P40
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FEM1B on UCSC Golden Path with GeneCards custom track

Promoters for FEM1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001453306 1944 5801 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 PPARGC1A

Genomic Location for FEM1B Gene

Chromosome:
15
Start:
68,277,756 bp from pter
End:
68,295,865 bp from pter
Size:
18,110 bases
Orientation:
Plus strand

Genomic View for FEM1B Gene

Genes around FEM1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1B Gene

Proteins for FEM1B Gene

  • Protein details for FEM1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK73-FEM1B_HUMAN
    Recommended name:
    Protein fem-1 homolog B
    Protein Accession:
    Q9UK73
    Secondary Accessions:
    • O43146

    Protein attributes for FEM1B Gene

    Size:
    627 amino acids
    Molecular mass:
    70264 Da
    Quaternary structure:
    • Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.

neXtProt entry for FEM1B Gene

Post-translational modifications for FEM1B Gene

  • Ubiquitination at Lys 469
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1B Gene

No data available for DME Specific Peptides for FEM1B Gene

Domains & Families for FEM1B Gene

Gene Families for FEM1B Gene

Protein Domains for FEM1B Gene

Suggested Antigen Peptide Sequences for FEM1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK73

UniProtKB/Swiss-Prot:

FEM1B_HUMAN :
  • Belongs to the fem-1 family.
  • Contains 8 ANK repeats.
Family:
  • Belongs to the fem-1 family.
Similarity:
  • Contains 8 ANK repeats.
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with FEM1B: view

Function for FEM1B Gene

Molecular function for FEM1B Gene

UniProtKB/Swiss-Prot Function:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

Gene Ontology (GO) - Molecular Function for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 15601820
GO:0005123 death receptor binding NAS 10623617
GO:0005515 protein binding IPI 11559703
genes like me logo Genes that share ontologies with FEM1B: view
genes like me logo Genes that share phenotypes with FEM1B: view

Animal Models for FEM1B Gene

MGI Knock Outs for FEM1B:

Animal Model Products

miRNA for FEM1B Gene

miRTarBase miRNAs that target FEM1B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FEM1B Gene

Localization for FEM1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1B Gene

Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEM1B gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19330022
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 19330022
genes like me logo Genes that share ontologies with FEM1B: view

Pathways & Interactions for FEM1B Gene

SuperPathways for FEM1B Gene

No Data Available

UniProtKB/Swiss-Prot Q9UK73-FEM1B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 10623617
GO:0016567 protein ubiquitination IEA --
GO:0051438 regulation of ubiquitin-protein transferase activity IMP 15601820
GO:0060442 branching involved in prostate gland morphogenesis IEA --
GO:0060743 epithelial cell maturation involved in prostate gland development IEA --
genes like me logo Genes that share ontologies with FEM1B: view

No data available for Pathways by source and SIGNOR curated interactions for FEM1B Gene

Transcripts for FEM1B Gene

Unigene Clusters for FEM1B Gene

Fem-1 homolog b (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FEM1B Gene

GeneLoc Exon Structure for
FEM1B
ECgene alternative splicing isoforms for
FEM1B

Expression for FEM1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FEM1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FEM1B Gene

This gene is overexpressed in Lung (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEM1B Gene



Protein tissue co-expression partners for FEM1B Gene

NURSA nuclear receptor signaling pathways regulating expression of FEM1B Gene:

FEM1B

SOURCE GeneReport for Unigene cluster for FEM1B Gene:

Hs.362733

mRNA Expression by UniProt/SwissProt for FEM1B Gene:

Q9UK73-FEM1B_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
genes like me logo Genes that share expression patterns with FEM1B: view

Primer Products

No data available for mRNA differential expression in normal tissues for FEM1B Gene

Orthologs for FEM1B Gene

This gene was present in the common ancestor of animals.

Orthologs for FEM1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEM1B 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia FEM1B 34 35
  • 94.05 (n)
dog
(Canis familiaris)
Mammalia FEM1B 34 35
  • 93.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FEM1B 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fem1b 34
  • 90.64 (n)
mouse
(Mus musculus)
Mammalia Fem1b 34 16 35
  • 90.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FEM1B 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves FEM1B 34 35
  • 78.42 (n)
lizard
(Anolis carolinensis)
Reptilia FEM1B 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fem1b 34
  • 73.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11486 34
zebrafish
(Danio rerio)
Actinopterygii fem1b 34 35
  • 70.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fem-1 34 35
  • 49.16 (n)
CG9025 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007382 34
  • 49.14 (n)
worm
(Caenorhabditis elegans)
Secernentea C01H6.2 35
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4940 35
  • 47 (a)
OneToOne
Species where no ortholog for FEM1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEM1B Gene

ENSEMBL:
Gene Tree for FEM1B (if available)
TreeFam:
Gene Tree for FEM1B (if available)

Paralogs for FEM1B Gene

Paralogs for FEM1B Gene

(10) SIMAP similar genes for FEM1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FEM1B: view

Variants for FEM1B Gene

Sequence variations from dbSNP and Humsavar for FEM1B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152450 -- 68,279,141(+) TGGGC(G/T)TTAAT intron-variant
rs1043378 -- 68,291,300(+) TAATC(A/C)CAGAC utr-variant-3-prime
rs111294065 -- 68,283,358(+) CATAT(A/C)ATAAT intron-variant
rs111343207 -- 68,289,605(+) TGTGT(A/G)GGTAT splice-acceptor-variant
rs111367704 -- 68,288,408(+) TTGAT(-/C)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEM1B Gene

Variant ID Type Subtype PubMed ID
esv2760036 CNV loss 17122850

Variation tolerance for FEM1B Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEM1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEM1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1B Gene

Disorders for FEM1B Gene

Relevant External Links for FEM1B

Genetic Association Database (GAD)
FEM1B
Human Genome Epidemiology (HuGE) Navigator
FEM1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FEM1B

No disorders were found for FEM1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEM1B Gene

Publications for FEM1B Gene

  1. Sequence, organization, and expression of the human FEM1B gene. (PMID: 10623617) Ventura-Holman T. … Maher J.F. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  2. Family-based analysis of candidate genes for polycystic ovary syndrome. (PMID: 20200332) Ewens K.G. … Spielman R.S. (J. Clin. Endocrinol. Metab. 2010) 3 46 64
  3. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M. … Ramoni M.F. (Circulation 2009) 3 46 64
  4. Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. (PMID: 19330022) Sun T.P. … Shieh S.Y. (Oncogene 2009) 3 4 64
  5. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PMID: 18757445) Goodarzi M.O. … Azziz R. (Hum. Reprod. 2008) 3 46 64

Products for FEM1B Gene

Sources for FEM1B Gene

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