Aliases for FEM1B Gene
Aliases for FEM1B Gene
External Ids for FEM1B Gene
- HGNC: 3649
- Entrez Gene: 10116
- Ensembl: ENSG00000169018
- OMIM: 613539
- UniProtKB: Q9UK73
Previous GeneCards Identifiers for FEM1B Gene
- GC15P064410
- GC15P061668
- GC15P066148
- GC15P066285
- GC15P066357
- GC15P068570
- GC15P045400
- GC15P068278
Summaries for FEM1B Gene
-
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
GeneCards Summary for FEM1B Gene
FEM1B (Fem-1 Homolog B) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and death receptor binding. An important paralog of this gene is FEM1C.
UniProtKB/Swiss-Prot for FEM1B Gene
-
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1B Gene
Genomics for FEM1B Gene
Regulatory Elements for FEM1B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH15G068298 | 1.4 | Ensembl ENCODE dbSUPER | 12.4 | +21.9 | 21863 | 2.6 | ELF3 FOXA2 RAD21 RARA YY1 ZNF121 SCRT2 RELB IKZF2 CREM | ENSG00000260657 FEM1B PIAS1 GC15M068298 |
| GH15G068306 | 1.4 | Ensembl ENCODE dbSUPER | 12.3 | +29.0 | 28960 | 1.0 | ZNF473 ZNF2 RAD21 RFX5 EGR1 ZNF143 RCOR1 RELB MIXL1 DEK | ENSG00000260657 FEM1B GC15M068298 ITGA11 |
| GH15G068256 | 1.2 | ENCODE dbSUPER | 12.4 | -20.7 | -20699 | 1.6 | ELF3 ARID4B SIN3A ZNF48 RAD21 YY1 THAP11 ZNF202 JUNB CEBPB | FEM1B CLN6 HMGN2P40 |
| GH15G068312 | 1.2 | Ensembl dbSUPER | 11.3 | +35.4 | 35355 | 0.6 | PKNOX1 KLF17 INSM2 FEZF1 ZNF366 EGR1 SCRT2 ZSCAN5C FOS EGR2 | ENSG00000260657 FEM1B ITGA11 GC15M068298 |
| GH15G068227 | 1.1 | ENCODE | 11.4 | -48.5 | -48514 | 3.6 | HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZBTB7B ZNF766 | IQCH-AS1 CLN6 FEM1B PIAS1 RNU6-1 LOC101929076 SKOR1 ENSG00000260007 CALML4 |
- Transcription factor binding sites by QIAGEN in the FEM1B gene promoter:
Regulatory Element Products
Genomic Location for FEM1B Gene
- Chromosome:
- 15
- Start:
- 68,277,756 bp from pter
- End:
- 68,295,865 bp from pter
- Size:
- 18,110 bases
- Orientation:
- Plus strand
Genomic View for FEM1B Gene
- Cytogenetic band:
-
- 15q23 by Ensembl
- 15q23 by Entrez Gene
- 15q23 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FEM1B Gene
Proteins for FEM1B Gene
-
Protein details for FEM1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UK73-FEM1B_HUMAN
- Recommended name:
- Protein fem-1 homolog B
- Protein Accession:
- Q9UK73
- O43146
Protein attributes for FEM1B Gene
- Size:
- 627 amino acids
- Molecular mass:
- 70264 Da
- Quaternary structure:
-
- Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, ELOB, ELOC and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.
Protein Expression for FEM1B Gene
Post-translational modifications for FEM1B Gene
Other Protein References for FEM1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
No data available for DME Specific Peptides for FEM1B Gene
Domains & Families for FEM1B Gene
Gene Families for FEM1B Gene
Protein Domains for FEM1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FEM1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UK73- Family:
-
- Belongs to the fem-1 family.
Function for FEM1B Gene
Molecular function for FEM1B Gene
- UniProtKB/Swiss-Prot Function:
- Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IMP | 15601820 |
| GO:0005123 | death receptor binding | NAS | 10623617 |
| GO:0005515 | protein binding | IPI | 11559703 |
Phenotypes for FEM1B Gene
- MGI mutant phenotypes for FEM1B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FEM1B:
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miRNA for FEM1B Gene
- miRTarBase miRNAs that target FEM1B
-
- hsa-mir-186-5p (MIRT044948)
- hsa-mir-30b-5p (MIRT046117)
- hsa-mir-10b-5p (MIRT047427)
- hsa-mir-10a-5p (MIRT047584)
- hsa-mir-30d-5p (MIRT047779)
- hsa-mir-30c-5p (MIRT047848)
- hsa-mir-578 (MIRT476872)
- hsa-mir-6715b-3p (MIRT476873)
- hsa-mir-3655 (MIRT476874)
- hsa-mir-3682-5p (MIRT476875)
- hsa-mir-138-1-3p (MIRT476876)
- hsa-mir-3609 (MIRT476877)
- hsa-mir-548ah-5p (MIRT476878)
- hsa-mir-1229-5p (MIRT507278)
- hsa-mir-6783-3p (MIRT507279)
- hsa-mir-1343-3p (MIRT507280)
- hsa-mir-340-5p (MIRT507281)
- hsa-mir-4473 (MIRT507282)
- hsa-mir-4662a-5p (MIRT507283)
- hsa-mir-4711-3p (MIRT507284)
- hsa-mir-550a-3p (MIRT507285)
- hsa-mir-200c-5p (MIRT507286)
- hsa-mir-3132 (MIRT507287)
- hsa-mir-197-5p (MIRT507288)
- hsa-mir-138-5p (MIRT507289)
- hsa-mir-6131 (MIRT507290)
- hsa-mir-133a-5p (MIRT507291)
- hsa-mir-6499-3p (MIRT507292)
- hsa-mir-302a-5p (MIRT507293)
- hsa-mir-7152-3p (MIRT507294)
- hsa-mir-6861-5p (MIRT507295)
- hsa-mir-6758-3p (MIRT507296)
- hsa-mir-6742-3p (MIRT507297)
- hsa-mir-6852-5p (MIRT507298)
- hsa-mir-939-3p (MIRT507299)
- hsa-mir-153-5p (MIRT507300)
- hsa-mir-1250-3p (MIRT507301)
- hsa-mir-6733-3p (MIRT507302)
- hsa-mir-520f-3p (MIRT507303)
- hsa-mir-302c-3p (MIRT507304)
- hsa-mir-512-3p (MIRT507305)
- hsa-mir-4519 (MIRT507306)
- hsa-mir-3121-3p (MIRT507307)
- hsa-mir-5692a (MIRT507308)
- hsa-mir-6792-5p (MIRT507309)
- hsa-mir-646 (MIRT507310)
- hsa-mir-5003-3p (MIRT507311)
- hsa-mir-374b-3p (MIRT548233)
- hsa-mir-5682 (MIRT548234)
- hsa-mir-585-5p (MIRT548235)
- hsa-mir-6871-3p (MIRT548236)
- hsa-mir-29b-3p (MIRT548237)
- hsa-mir-29a-3p (MIRT548238)
- hsa-mir-29c-3p (MIRT548239)
- hsa-mir-514b-3p (MIRT557873)
- hsa-mir-514a-3p (MIRT557874)
- hsa-mir-4477a (MIRT557875)
- hsa-mir-5087 (MIRT557876)
- hsa-mir-3913-3p (MIRT557877)
- hsa-mir-4307 (MIRT557878)
- hsa-mir-499b-3p (MIRT557879)
- hsa-mir-499a-3p (MIRT557880)
- hsa-mir-519c-3p (MIRT557881)
- hsa-mir-519b-3p (MIRT557882)
- hsa-mir-519a-3p (MIRT557883)
- hsa-mir-224-5p (MIRT557884)
- hsa-mir-522-3p (MIRT557885)
- hsa-mir-224-3p (MIRT557886)
- hsa-mir-4694-3p (MIRT557887)
- hsa-mir-6507-3p (MIRT557888)
- hsa-mir-106b-5p (MIRT557889)
- hsa-mir-17-5p (MIRT557890)
- hsa-mir-106a-5p (MIRT557891)
- hsa-mir-20a-5p (MIRT557892)
- hsa-mir-20b-5p (MIRT557893)
- hsa-mir-519d-3p (MIRT557894)
- hsa-mir-526b-3p (MIRT557895)
- hsa-mir-93-5p (MIRT557896)
- hsa-mir-489-3p (MIRT557897)
- hsa-mir-6083 (MIRT567579)
- hsa-mir-4326 (MIRT567580)
- hsa-mir-26b-3p (MIRT567581)
- hsa-mir-5006-3p (MIRT616711)
- hsa-mir-4755-5p (MIRT616712)
- hsa-mir-511-5p (MIRT616713)
- hsa-mir-514b-5p (MIRT616714)
- hsa-mir-513c-5p (MIRT616715)
- hsa-mir-211-5p (MIRT616716)
- hsa-mir-204-5p (MIRT616717)
- hsa-mir-623 (MIRT616718)
- hsa-mir-4291 (MIRT616719)
- hsa-mir-6740-3p (MIRT616720)
- hsa-mir-372-5p (MIRT616721)
- hsa-mir-371a-5p (MIRT616722)
- hsa-mir-616-5p (MIRT616723)
- hsa-mir-373-5p (MIRT616724)
- hsa-mir-371b-5p (MIRT616725)
- hsa-mir-5088-3p (MIRT616726)
- hsa-mir-7157-5p (MIRT616727)
- hsa-mir-4310 (MIRT616728)
- hsa-mir-4698 (MIRT616729)
- hsa-mir-8063 (MIRT616730)
- hsa-mir-4659b-3p (MIRT641239)
- hsa-mir-4659a-3p (MIRT641240)
- hsa-mir-6875-3p (MIRT641241)
- hsa-mir-27b-3p (MIRT727658)
- hsa-mir-27a-3p (MIRT727660)
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FEM1B Gene
Localization for FEM1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FEM1B Gene
- Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 19330022 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 19330022 |
| GO:0005829 | cytosol | TAS,IDA | -- |
Pathways & Interactions for FEM1B Gene
UniProtKB/Swiss-Prot Q9UK73-FEM1B_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FEM1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | NAS | 10623617 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0051438 | regulation of ubiquitin-protein transferase activity | IMP | 15601820 |
| GO:0060442 | branching involved in prostate gland morphogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FEM1B Gene
Transcripts for FEM1B Gene
mRNA/cDNA for FEM1B Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (247) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FEM1B Gene
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| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||
| SP4: | - | - | |||||||||||||||||
| SP5: | - |
Expression for FEM1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Testis Interstitium
- Neural Tube (Nervous System)
- Blood (Hematopoietic System)
-
Larynx (Respiratory System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEM1B Gene
NURSA nuclear receptor signaling pathways regulating expression of FEM1B Gene:
FEM1BSOURCE GeneReport for Unigene cluster for FEM1B Gene:
Hs.362733mRNA Expression by UniProt/SwissProt for FEM1B Gene:
Q9UK73-FEM1B_HUMANEvidence on tissue expression from TISSUES for FEM1B Gene
- Nervous system(4.4)
Primer Products
-
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-
OriGene qPCR primer pairs and template standards for FEM1B
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEM1B Gene
Orthologs for FEM1B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FEM1B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FEM1B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FEM1B 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FEM1B 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fem1b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fem1b 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FEM1B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FEM1B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FEM1B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fem1b 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11486 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fem1b 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fem-1 34 35 |
|
||
| CG9025 36 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007382 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C01H6.2 35 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4940 35 |
|
OneToOne |
- Species where no ortholog for FEM1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FEM1B Gene
(10) SIMAP similar genes for FEM1B Gene using alignment to 3 proteins:
Variants for FEM1B Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000254905 | -- | 68,294,247(+) | AGCCC(A/G)CAGCC | utr-variant-3-prime | |
| rs1000434228 | -- | 68,275,829(+) | TTCAG(A/G)AACAT | upstream-variant-2KB | |
| rs1000466750 | -- | 68,276,006(+) | AGACA(A/G)ATGGT | upstream-variant-2KB | |
| rs1000530405 | -- | 68,288,950(+) | ATCCT(C/T)ACTTC | intron-variant | |
| rs1000542422 | -- | 68,282,331(+) | AGGGG(C/T)ATGCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2760036 | CNV | loss | 17122850 |
Relevant External Links for FEM1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FEM1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1B Gene
Disorders for FEM1B Gene
Relevant External Links for FEM1B
No disorders were found for FEM1B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEM1B Gene
Publications for FEM1B Gene
- Sequence, organization, and expression of the human FEM1B gene. (PMID: 10623617) Ventura-Holman T. … Maher J.F. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
- Family-based analysis of candidate genes for polycystic ovary syndrome. (PMID: 20200332) Ewens K.G. … Spielman R.S. (J. Clin. Endocrinol. Metab. 2010) 3 46 64
- Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M. … Ramoni M.F. (Circulation 2009) 3 46 64
- Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. (PMID: 19330022) Sun T.P. … Shieh S.Y. (Oncogene 2009) 3 4 64
- FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PMID: 18757445) Goodarzi M.O. … Azziz R. (Hum. Reprod. 2008) 3 46 64
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- Search antibodies-online for peptides
- GeneTex FEM1B antibody for FEM1B
- Search GeneTex for Proteins for FEM1B
- ViGene Biosciences adenoviral particle packaged cDNA for FEM1B gene
- ViGene Biosciences lentiviral particle packaged cDNA for FEM1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for FEM1B gene
- Search ViGene Biosciences for FEM1B
- Custom Antibody ServicesProSci Antibodies for FEM1B
- Search for FEM1B Proteins at ProSci
- Horizon Cell Lines for FEM1B
- Cyagen custom Knockout/knockin (KOKI) mouse models for FEM1B
- VectorBuilder custom plasmid, inducible vectors for FEM1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FEM1B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FEM1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




