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Aliases for FEM1B Gene

Aliases for FEM1B Gene

  • Fem-1 Homolog B (C. Elegans) 2 3
  • Fem-1-Like Death Receptor-Binding Protein Alpha 3 4
  • Fem-1-Like In Apoptotic Pathway Protein Alpha 3 4
  • F1A-ALPHA 3 4
  • FEM1-Beta 3 4
  • F1AA 3 4
  • FEM-1-Like Death Receptor Binding Protein 3
  • FEM-1 (C. Elegans) Homolog B 2
  • Protein Fem-1 Homolog B 3
  • KIAA0396 4
  • FEM1b 4

External Ids for FEM1B Gene

Previous GeneCards Identifiers for FEM1B Gene

  • GC15P064410
  • GC15P061668
  • GC15P066148
  • GC15P066285
  • GC15P066357
  • GC15P068570
  • GC15P045400

Summaries for FEM1B Gene

Entrez Gene Summary for FEM1B Gene

  • This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

GeneCards Summary for FEM1B Gene

FEM1B (Fem-1 Homolog B (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and death receptor binding. An important paralog of this gene is TANC1.

UniProtKB/Swiss-Prot for FEM1B Gene

  • Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1B Gene

Genomics for FEM1B Gene

Regulatory Elements for FEM1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FEM1B Gene

Start:
68,277,803 bp from pter
End:
68,295,865 bp from pter
Size:
18,063 bases
Orientation:
Plus strand

Genomic View for FEM1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FEM1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1B Gene

Proteins for FEM1B Gene

  • Protein details for FEM1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK73-FEM1B_HUMAN
    Recommended name:
    Protein fem-1 homolog B
    Protein Accession:
    Q9UK73
    Secondary Accessions:
    • O43146

    Protein attributes for FEM1B Gene

    Size:
    627 amino acids
    Molecular mass:
    70264 Da
    Quaternary structure:
    • Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.

neXtProt entry for FEM1B Gene

Proteomics data for FEM1B Gene at MOPED

Post-translational modifications for FEM1B Gene

  • Ubiquitination at Lys469
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1B Gene

No data available for DME Specific Peptides for FEM1B Gene

Domains for FEM1B Gene

Gene Families for FEM1B Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for FEM1B Gene

Suggested Antigen Peptide Sequences for FEM1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK73

UniProtKB/Swiss-Prot:

FEM1B_HUMAN :
  • Q9UK73
Family:
  • Belongs to the fem-1 family.
Similarity:
  • Contains 8 ANK repeats.
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with FEM1B: view

Function for FEM1B Gene

Molecular function for FEM1B Gene

UniProtKB/Swiss-Prot Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

Gene Ontology (GO) - Molecular Function for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 15601820
GO:0005123 death receptor binding NAS 10623617
GO:0005515 protein binding IPI 11559703
genes like me logo Genes that share ontologies with FEM1B: view
genes like me logo Genes that share phenotypes with FEM1B: view

Animal Models for FEM1B Gene

MGI Knock Outs for FEM1B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FEM1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FEM1B Gene

Localization for FEM1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1B Gene

Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FEM1B Gene COMPARTMENTS Subcellular localization image for FEM1B gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19330022
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FEM1B: view

Pathways for FEM1B Gene

SuperPathways for FEM1B Gene

No Data Available

PCR Array Products

UniProtKB/Swiss-Prot Q9UK73-FEM1B_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002070 epithelial cell maturation --
GO:0006915 apoptotic process NAS 10623617
GO:0016567 protein ubiquitination IEA --
GO:0051438 regulation of ubiquitin-protein transferase activity IMP 15601820
GO:0060442 branching involved in prostate gland morphogenesis IEA --
genes like me logo Genes that share ontologies with FEM1B: view

No data available for Pathways by source for FEM1B Gene

Transcripts for FEM1B Gene

Unigene Clusters for FEM1B Gene

Fem-1 homolog b (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FEM1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FEM1B Gene

GeneLoc Exon Structure for
FEM1B
ECgene alternative splicing isoforms for
FEM1B

Expression for FEM1B Gene

mRNA expression in normal human tissues for FEM1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FEM1B Gene

SOURCE GeneReport for Unigene cluster for FEM1B Gene Hs.362733

mRNA Expression by UniProt/SwissProt for FEM1B Gene

Q9UK73-FEM1B_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
genes like me logo Genes that share expressions with FEM1B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FEM1B Gene

Orthologs for FEM1B Gene

This gene was present in the common ancestor of animals.

Orthologs for FEM1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEM1B 35
  • 99.84 (n)
  • 100 (a)
FEM1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FEM1B 35
  • 94.05 (n)
  • 99.52 (a)
FEM1B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FEM1B 35
  • 93.78 (n)
  • 98.56 (a)
FEM1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fem1b 35
  • 90.38 (n)
  • 99.04 (a)
Fem1b 16
Fem1b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FEM1B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FEM1B 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fem1b 35
  • 90.64 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves FEM1B 35
  • 78.42 (n)
  • 90.75 (a)
FEM1B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FEM1B 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11486 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fem1b 35
  • 73.15 (n)
  • 83.89 (a)
zebrafish
(Danio rerio)
Actinopterygii fem1b 35
  • 70.28 (n)
  • 80.22 (a)
fem1b 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007382 35
  • 49.14 (n)
  • 44.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fem-1 35
  • 49.16 (n)
  • 42.09 (a)
Fem-1 36
  • 36 (a)
OneToOne
CG9025 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea C01H6.2 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4940 36
  • 47 (a)
OneToOne
Species with no ortholog for FEM1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEM1B Gene

ENSEMBL:
Gene Tree for FEM1B (if available)
TreeFam:
Gene Tree for FEM1B (if available)

Paralogs for FEM1B Gene

Selected SIMAP similar genes for FEM1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FEM1B: view

Variants for FEM1B Gene

Sequence variations from dbSNP and Humsavar for FEM1B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1043378 -- 68,291,300(+) TAATC(A/C)CAGAC utr-variant-3-prime
rs1227308 -- 68,285,956(+) ttcca(A/G)aaatt intron-variant
rs1228663 -- 68,286,044(+) tactg(G/T)gtctc intron-variant
rs1228664 -- 68,286,068(+) tactg(G/T)gaggt intron-variant
rs1236841 -- 68,285,985(+) attaa(A/G)aatag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FEM1B Gene

Variant ID Type Subtype PubMed ID
dgv752e1 CNV Complex 17122850

Relevant External Links for FEM1B Gene

HapMap Linkage Disequilibrium report
FEM1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1B Gene

Disorders for FEM1B Gene

Relevant External Links for FEM1B

Genetic Association Database (GAD)
FEM1B
Human Genome Epidemiology (HuGE) Navigator
FEM1B
genes like me logo Genes that share disorders with FEM1B: view

No data available for UniProtKB/Swiss-Prot for FEM1B Gene

Publications for FEM1B Gene

  1. Sequence, organization, and expression of the human FEM1B gene. (PMID: 10623617) Ventura-Holman T. … Maher J.F. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  3. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. (PMID: 10542291) Chan S.-L. … Yu V.C. (J. Biol. Chem. 1999) 3 4
  4. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PMID: 15601820) Kamura T. … Nakayama K.I. (Genes Dev. 2004) 3 4
  5. The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PMID: 11559703) Tan K.M.L. … Yu V.C. (J. Biol. Chem. 2001) 3 4

Products for FEM1B Gene

Sources for FEM1B Gene

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