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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FEM1B Gene

protein-coding   GIFtS: 53
GCID: GC15P068570

fem-1 homolog b (C. elegans)

(Previous name: FEM-1 (C. elegans) homolog b )
 Explore 6 diseases affiliated with
FEM1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FEM1B    

Aliases
for FEM1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fem-1 Homolog B (C. Elegans)1 2     FEM-1-Like Death Receptor Binding Protein2
Fem-1-Like Death Receptor-Binding Protein Alpha2 3     Protein Fem-1 Homolog B2
Fem-1-Like In Apoptotic Pathway Protein Alpha2 3     F1A-Alpha1
FEM1-Beta1     F1AA3
FEM-1 (C. Elegans) Homolog B1     FEM1b3
F1A-ALPHA2     KIAA03963
FIAA2     

External Ids:    HGNC: 36491   Entrez Gene: 101162   Ensembl: ENSG000001690187   OMIM: 6135395   UniProtKB: Q9UK733   

Export aliases for FEM1B gene to outside databases

Previous GC identifers: GC15P064410 GC15P061668 GC15P066148 GC15P066285 GC15P066357 GC15P045400


Summaries
for FEM1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.
Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in
glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that
leads to the activation of CHEK1




Genomic Views
for FEM1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FEM1B gene promoter:
         PPAR-alpha   Bach1   AML1a   p53   Pax-5   Nkx2-2   MRF-2   GATA-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FEM1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22

FEM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEM1B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P068570:  view genomic region     (about GC identifiers)

Start:
 68,570,141 bp from pter      End:
 68,588,203 bp from pter
Size:
 18,063 bases      Orientation:
 plus strand

Proteins
for FEM1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73 (See protein sequence)
Recommended Name: Protein fem-1 homolog B  
Size: 627 amino acids; 70264 Da
Subunit: Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1,
TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A.
Interacts with CHEK1
Subcellular location: Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin
(CPT) treatment. Associated with chromatin
Secondary accessions: O43146

Explore the universe of human proteins at neXtProt for FEM1B: NX_Q9UK73

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UK73

    • FEM1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056137.1  
    ENSEMBL proteins: 
     ENSP00000307298   ENSP00000457002   ENSP00000457342   ENSP00000456968  

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    Uscn Proteins for FEM1B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA19330022


    FEM1B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FEM1B

    Protein Domains /
    Families
    for FEM1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FEM1B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9UK73

    ProtoNet protein and cluster: Q9UK73

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Similarity: Belongs to the fem-1 family
    Similarity: Contains 8 ANK repeats
    Similarity: Contains 1 TPR repeat


    Function
    for FEM1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.
    Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in
    glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that
    leads to the activation of CHEK1

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: FEM1B
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP15601820
    GO:0005123death receptor binding NAS10623617
    GO:0005515protein binding IPI17003112


    FEM1B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for FEM1B: Fem1btm1Jfma Fem1btm1Mms
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fem1b):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    FEM1B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FEM1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FEM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/22 Interacting proteins for FEM1B (Q9UK732, 3 ENSP000003072984) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPM1FP495932, 3, ENSP000002632124MINT-8215474 MINT-8215483 I2D: score=1 STRING: ENSP00000263212
    CUL2Q136173, ENSP000003638804I2D: score=2 STRING: ENSP00000363880
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    RBX1P628773, ENSP000002162254I2D: score=2 STRING: ENSP00000216225
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002070epithelial cell maturation ----
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis NAS10623617
    GO:0016567protein ubiquitination ----
    GO:0042981regulation of apoptotic process IMP10542291


    FEM1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for FEM1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FEM1B
    Search CenterWatch for drugs/clinical trials and news about FEM1B 

    Transcripts
    for FEM1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FEM1B gene: 
    NM_015322.3  

    Unigene Cluster for FEM1B:

    Fem-1 homolog b (C. elegans)
    Hs.362733  [show with all ESTs]
    Unigene Representative Sequence: AL833264
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306917(uc002arg.3) ENST00000570067 ENST00000566739 ENST00000566008


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    Inhib. RNA
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    OriGene shRNA RFP: FEM1B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB007856.2 AF178632.1 AF204883.1 AK098620.1 AK290167.1 AL833264.1 BC010122.2 BC014558.2 

    3 DOTS entries:

    DT.40269875  DT.100754756  DT.121025984 

    24/247 AceView cDNA sequences (see all 247):

    AI685927 BM829540 AU130679 AI377359 BC010122 CB243690 BM719400 BM563269 
    AF178632 BM988065 AI372871 BE018229 CK000753 BM454598 AF204883 AI418166 
    CR612333 W60202 AL711376 BQ549332 AA961254 BF112021 BU190194 AA348019 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FEM1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:        -     -     -                                       
    SP4:              -     -                                       
    SP5:                    -                                       


    ECgene alternative splicing isoforms for FEM1B

    Expression
    for FEM1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FEM1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTTTTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FEM1B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FEM1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FEM1B

    SOURCE GeneReport for Unigene cluster: Hs.362733

    UniProtKB/Swiss-Prot: FEM1B_HUMAN, Q9UK73
    Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including FEM1B: 
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for FEM1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FEM1B gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FEM1B1 fem-1 homolog b (C. elegans) 78.36(n)
    90.75(a)    		   415559  NM_001030553.1  NP_001025724.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FEM1B6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343467.1(770295-776112)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.114862 Xenopus laevis transcribed sequence with moderate similarity more 77.84(n)    BJ062223.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fem1b1 fem-1 homolog b (C. elegans) 70.33(n)
    80.22(a)    		   567119  XM_690410.4  XP_695502.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG90253
    Fem-11    		 CG9025-PA1 45(a)3
    48.82(n)1
    41.45(a)1    		   57A93
    373441  NM_137664.21  NP_611508.11 


    ENSEMBL Gene Tree for FEM1B (if available)
    TreeFam Gene Tree for FEM1B (if available) 

    Paralogs
    for FEM1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FEM1B gene
    ANKRD292  FEM1A2  KIDINS2202  FEM1C2  
    9 SIMAP similar genes for FEM1B using alignment to 3 protein entries:     FEM1B_HUMAN (see all proteins):
    ANKRD6    FEM1C    ANKRD29    PPP1R12C    RFXANK    FEM1A
    ANKRD12    TANC2    CASKIN2

    FEM1B for paralogs           About GeneDecksing



    Genomic Variants
    for FEM1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FEM1B
         1 CNV: 3965
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FEM1B
    DNA2.0 Custom Variant and Variant Library Synthesis for FEM1B

    Disorders / Diseases
    for FEM1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FEM1B for disorders           About GeneDecksing

    OMIM gene information: 613539    OMIM disorders: --

    6 diseases for FEM1B:    About MalaCards
    polycystic ovary syndrome    colon cancer    atherosclerosis    hypoxia
    pancreatitis    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: FEM1B (3 documents)

    Export disorders for FEM1B gene to outside databases

    Publications
    for FEM1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FEM1B gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with FEM1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, organization, and expression of the human FEM1B gene. (PubMed id 10623617)1, 2, 3 Ventura-Holman T. and Maher J.F. (2000)
    2. Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. (PubMed id 19330022)1, 2 Sun T.P. and Shieh S.Y. (2009)
    3. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (2004)
    4. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PubMed id 11559703)1, 2 Tan K.M....Yu V.C. (2001)
    5. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. (PubMed id 10542291)1, 2 Chan S.-L....Yu V.C. (1999)
    6. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Fem1b, a proapoptotic protein, mediates proteasome in hibitor-induced apoptosis of human colon cancer cells. (PubMed id 19908242)1 Subauste M.C....Maher J.F. (2010)

    External Searches for FEM1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing FEM1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10116 HGNC: 3649 AceView: FEM1B Ensembl:ENSG00000169018 euGenes: HUgn10116
    ECgene: FEM1B H-InvDB: FEM1B

    Other Databases showing FEM1B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0396

    Specialized Databases showing FEM1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for FEM1B Pharmacogenomics, SNPs, Pathways

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    		Patent Information for FEM1B gene:
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