Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FEM1A Gene

Aliases for FEM1A Gene

  • Fem-1 Homolog A (C. Elegans) 2 3
  • Prostaglandin E Receptor 4-Associated Protein 3 4
  • FEM1-Alpha 3 4
  • EPRAP 3 4
  • Protein Fem-1 Homolog A 3
  • FEM1A 4

External Ids for FEM1A Gene

Previous GeneCards Identifiers for FEM1A Gene

  • GC19P004883
  • GC19P004732
  • GC19P004742
  • GC19P004553

Summaries for FEM1A Gene

GeneCards Summary for FEM1A Gene

FEM1A (Fem-1 Homolog A (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and EP4 subtype prostaglandin E2 receptor binding. An important paralog of this gene is TANC1.

UniProtKB/Swiss-Prot for FEM1A Gene

  • Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1A Gene

Genomics for FEM1A Gene

Regulatory Elements for FEM1A Gene

Genomic Location for FEM1A Gene

4,791,681 bp from pter
4,801,273 bp from pter
9,593 bases
Plus strand

Genomic View for FEM1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FEM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1A Gene

Proteins for FEM1A Gene

  • Protein details for FEM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein fem-1 homolog A
    Protein Accession:
    Secondary Accessions:
    • B2RDI3
    • Q711P8
    • Q9NPN7
    • Q9NPW8

    Protein attributes for FEM1A Gene

    669 amino acids
    Molecular mass:
    73639 Da
    Quaternary structure:
    • Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.

neXtProt entry for FEM1A Gene

Proteomics data for FEM1A Gene at MOPED

Post-translational modifications for FEM1A Gene

  • Ubiquitination at Lys21, Lys182, Lys206, and Lys320
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEM1A Gene

Domains for FEM1A Gene

Gene Families for FEM1A Gene

  • ANKRD :Ankyrin repeat domain containing

Protein Domains for FEM1A Gene

Suggested Antigen Peptide Sequences for FEM1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BSK4
  • Belongs to the fem-1 family.
  • Contains 9 ANK repeats.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with FEM1A: view

Function for FEM1A Gene

Molecular function for FEM1A Gene

UniProtKB/Swiss-Prot Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.
UniProtKB/Swiss-Prot Induction: Frequently down-regulated in rhabdomyosarcoma.

Gene Ontology (GO) - Molecular Function for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding --
GO:0031867 EP4 subtype prostaglandin E2 receptor binding IPI 16424369
genes like me logo Genes that share ontologies with FEM1A: view

miRNA for FEM1A Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FEM1A Gene

Localization for FEM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1A Gene


Subcellular locations from

Jensen Localization Image for FEM1A Gene COMPARTMENTS Subcellular localization image for FEM1A gene
Compartment Confidence
cytosol 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FEM1A: view

Pathways for FEM1A Gene

SuperPathways for FEM1A Gene

No Data Available

UniProtKB/Swiss-Prot Q9BSK4-FEM1A_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0050728 negative regulation of inflammatory response IDA 16424369
GO:0051438 regulation of ubiquitin-protein transferase activity ISS --
genes like me logo Genes that share ontologies with FEM1A: view

No data available for Pathways by source for FEM1A Gene

Transcripts for FEM1A Gene

mRNA/cDNA for FEM1A Gene

(31) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FEM1A Gene

Fem-1 homolog a (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1A Gene

No ASD Table

Relevant External Links for FEM1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEM1A Gene

mRNA expression in normal human tissues for FEM1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEM1A Gene

This gene is overexpressed in Muscle - Skeletal (20.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FEM1A Gene

SOURCE GeneReport for Unigene cluster for FEM1A Gene Hs.515082

mRNA Expression by UniProt/SwissProt for FEM1A Gene

Tissue specificity: Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
genes like me logo Genes that share expressions with FEM1A: view

Orthologs for FEM1A Gene

This gene was present in the common ancestor of animals.

Orthologs for FEM1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FEM1A 35
  • 99.25 (n)
  • 99.4 (a)
FEM1A 36
  • 100 (a)
(Bos Taurus)
Mammalia FEM1A 35
  • 90.05 (n)
  • 95.41 (a)
FEM1A 36
  • 96 (a)
(Canis familiaris)
Mammalia FEM1A 35
  • 89.64 (n)
  • 95.17 (a)
(Mus musculus)
Mammalia 4931440F15Rik 36
  • 86 (a)
Fem1a 35
  • 83.84 (n)
  • 91.59 (a)
Fem1a 16
Fem1a 36
  • 91 (a)
(Monodelphis domestica)
Mammalia FEM1A 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FEM1A 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Fem1a 35
  • 82.72 (n)
  • 91.28 (a)
(Gallus gallus)
Aves FEM1A 35
  • 74.29 (n)
  • 81.65 (a)
FEM1A 36
  • 79 (a)
(Danio rerio)
Actinopterygii fem1a 35
  • 74.96 (n)
  • 75.12 (a)
fem1a 36
  • 73 (a)
wufi20c04 35
fruit fly
(Drosophila melanogaster)
Insecta CG6966 36
  • 50 (a)
CG6966 37
  • 49 (a)
CG11896 37
  • 30 (a)
(Caenorhabditis elegans)
Secernentea fem-1 36
  • 33 (a)
fem-1 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for FEM1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FEM1A Gene

Gene Tree for FEM1A (if available)
Gene Tree for FEM1A (if available)

Paralogs for FEM1A Gene

Selected SIMAP similar genes for FEM1A Gene using alignment to 1 proteins: Pseudogenes for FEM1A Gene

genes like me logo Genes that share paralogs with FEM1A: view

Variants for FEM1A Gene

Sequence variations from dbSNP and Humsavar for FEM1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11437 -- 4,795,333(+) GGAGT(G/T)TCCAG utr-variant-3-prime
rs1044386 -- 4,795,277(+) TCACT(A/G)CATCC utr-variant-3-prime
rs1044409 -- 4,795,330(+) CCGGG(A/G)GTGTC utr-variant-3-prime
rs3181004 -- 4,795,555(+) TCAAA(A/G)AGAAT utr-variant-3-prime
rs3214271 -- 4,794,936(+) TTGCA(-/AACCTCAC)GTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FEM1A Gene

Variant ID Type Subtype PubMed ID
nsv910847 CNV Loss 21882294
nsv910859 CNV Loss 21882294

Relevant External Links for FEM1A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1A Gene

Disorders for FEM1A Gene

Relevant External Links for FEM1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FEM1A: view

No data available for UniProtKB/Swiss-Prot for FEM1A Gene

Publications for FEM1A Gene

  1. The Fem1a gene is downregulated in Rhabdomyosarcoma. (PMID: 16254458) Ventura-Holman T. … Maher J.F. (Tumor Biol. 2005) 3 4 23
  2. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. (PMID: 16424369) Takayama K. … Libby P. (Circ. Res. 2006) 3 4 23
  3. FEM1A is a candidate gene for polycystic ovary syndrome. (PMID: 16390781) Maher J.F. … Cowan B.D. (Gynecol. Endocrinol. 2005) 3 4 48
  4. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 3
  5. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M. … Ramoni M.F. (Circulation 2009) 3 48

Products for FEM1A Gene

Sources for FEM1A Gene

Back to Top