FEM1A Gene
protein-coding GIFtS: 49
GCID: GC19P004791
|
|
fem-1 homolog a (C. elegans)
| |
Aliases
for FEM1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fem-1 Homolog A (C. Elegans)1 2 | | Prostaglandin E Receptor 4-Associated Protein2 3 | | EPRAP2 3 | | FEM1-Alpha1 | | Protein Fem-1 Homolog A2 | | FEM1a3 |
Export aliases for FEM1A gene to outside databasesPrevious GC identifers: GC19P004883 GC19P004732 GC19P004742 GC19P004553 |
Summaries
for FEM1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognitionsubunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4
|
Genomic Views
for FEM1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FEM1A gene promoter:
Pax-5 SREBP-1c Lmo2 AP-4 SREBP-1b YY1 E2F-1 SREBP-1a E2F Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FEM1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FEM1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3FEM1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P004791: view genomic region
(about GC identifiers)
Start:
|
4,791,728 bp from pter |
End:
|
4,795,571 bp from pter |
Size:
|
3,844 bases |
Orientation:
|
plus strand |
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Proteins
for FEM1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4 (See
protein sequence)Recommended Name: Protein fem-1 homolog A Size: 669 amino acids; 73639 Da
Subunit: Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4
Subcellular location: Cytoplasm (Probable)
Secondary accessions: B2RDI3 Q711P8 Q9NPN7 Q9NPW8Explore the universe of human proteins at neXtProt for FEM1A: NX_Q9BSK4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSK4
FEM1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061178.1
ENSEMBL proteins: ENSP00000269856
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
FEM1A for ontologies About GeneDecksing
FEM1A Antibody Products:
Assay Products for FEM1A: |
Protein
Domains /
Families
for FEM1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FEM1A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BSK4ProtoNet protein and cluster: Q9BSK4 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4Similarity: Belongs to the fem-1 familySimilarity: Contains 9 ANK repeatsSimilarity: Contains 2 TPR repeats |
Function
for FEM1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognitionsubunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4Induction: Frequently down-regulated in rhabdomyosarcoma
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
ISS | -- | | GO:0031867 | EP4 subtype prostaglandin E2 receptor binding |
IPI | 16424369 |
FEM1A for ontologies About GeneDecksing
|
Pathways & Interactions
for FEM1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4Pathway: Protein modification; protein ubiquitinationInteractions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FEM1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for FEM1A (Q9BSK43 ENSP000002698564) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
-- | -- | | GO:0050728 | negative regulation of inflammatory response |
IDA | 16424369 | | GO:0051438 | regulation of ubiquitin-protein ligase activity |
ISS | -- |
FEM1A for ontologies About GeneDecksing
|
Drugs & Compounds
for FEM1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FEM1A
Search CenterWatch for drugs/clinical trials and news about FEM1A
|
Transcripts
for FEM1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FEM1A gene: NM_018708.2 Unigene Cluster for FEM1A: Fem-1 homolog a (C. elegans) Hs.515082 [show with all ESTs]Unigene Representative Sequence: NM_0187081 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000269856(uc002mbf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FEM1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FEM1A (NM_018708) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FEM1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FEM1A |
Additional cDNA sequence: AJ311359.1 AK074232.1 AK126532.1 AK315554.1 AL359589.1 AL365408.1 AY356352.1 BC004988.1 CR749732.1 7 DOTS entries: DT.444040 DT.101981831 DT.75159514 DT.95090716 DT.95303560 DT.95090712 DT.95090715 24/31 AceView cDNA sequences (see all 31): BE855928 AI219669 BF447595 AA932849 AA731842 AI698736 AI951558 AA883966 AK126532 BQ340183 CA311661 BM553222 AA829913 AI245065 AW175962 AW804491 BM916748 AI220002 AW970630 AW754454 BM557537 BF816198 AW859780 BF815454
GeneLoc Exon Structure
|
Expression
for FEM1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FEM1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAGTCTCC
About this image
See FEM1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FEM1A
SOURCE GeneReport for Unigene cluster: Hs.515082
UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4Tissue specificity: Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (atprotein level)
SABiosciences Custom PCR Arrays for FEM1A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FEM1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FEM1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FEM1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FEM1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1A |
Orthologs
for FEM1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FEM1A gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FEM1A1 |
fem-1 homolog a (C. elegans) |
74.59(n)
82.11(a) |
|
420157 XM_418271.3 XP_418271.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi20c042 |
wufi20c04 |
77.53(n) |
|
327613 BC060522.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG69663 |
-- |
49(a)
(best of 2) |
|
88E1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
fem-13 |
Expression: all somatic, embryo, L1 larva,
L2 more |
39(a) |
|
IV(5533595-5538047) -- |
ENSEMBL Gene Tree for FEM1A (if available)
TreeFam Gene Tree for FEM1A (if available) |
Paralogs
for FEM1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FEM1A gene
- ANKRD292 FEM1B2 KIDINS2202 FEM1C2
2 SIMAP similar genes for FEM1A using alignment to 1 protein entry: FEM1A_HUMAN:FEM1C FEM1B
FEM1A for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for FEM1A
PGOHUM00000248499 PGOHUM00000234877 PGOHUM00000239133 PGOHUM00000243331
|
Genomic Variants
for FEM1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FEM1A (4791728 - 4795571 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FEM1A: --
Human Gene Mutation Database (HGMD): FEM1A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FEM1A |
|
Disorders
/ Diseases
for FEM1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FEM1A for disorders About GeneDecksing
OMIM gene information: 613538
OMIM disorders: --
3  diseases for FEM1A: About MalaCardspolycystic ovary syndrome rhabdomyosarcoma atherosclerosis
Human Genome Epidemiology (HuGE) Navigator: FEM1A (7 documents)
Export disorders for FEM1A gene to outside databases
|
Publications
for FEM1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FEM1A gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with FEM1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. (PubMed id 16424369)1, 2, 9 Takayama K.... Libby P. (2006)
- The Fem1a gene is downregulated in Rhabdomyosarcoma. (PubMed id 16254458)1, 2, 9 Ventura-Holman T.... Maher J.F. (2005)
- FEM1A is a candidate gene for polycystic ovary syndrome. (PubMed id 16390781)1, 2 Maher J.F.... Cowan B.D. (2005)
- Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (2001)
- [Polymorphisms of FEM1A gene in patients with polycyst ic ovary syndrome]. (PubMed id 22678803)1 Lin Y. and Sun Y. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Family-based analysis of candidate genes for polycyst ic ovary syndrome. (PubMed id 20200332)1 Ewens K.G....Spielman R.S. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for FEM1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FEM1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FEM1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FEM1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FEM1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FEM1A gene:
Search GeneIP for patents involving FEM1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FEM1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FEM1A |
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