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FEM1A Gene

protein-coding   GIFtS: 54
GCID: GC19P004791

Fem-1 Homolog A (C. Elegans)

  Search for FEM1A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fem-1 Homolog A (C. Elegans)1 2
Prostaglandin E Receptor 4-Associated Protein2 3
EPRAP2 3
FEM1-alpha2 3
Protein Fem-1 Homolog A2
FEM1a3

External Ids:    HGNC: 169341   Entrez Gene: 555272   Ensembl: ENSG000001419657   OMIM: 6135385   UniProtKB: Q9BSK43   

Export aliases for FEM1A gene to outside databases

Previous GC identifers: GC19P004883 GC19P004732 GC19P004742 GC19P004553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FEM1A Gene:
FEM1A (fem-1 homolog a (C. elegans)) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and EP4 subtype prostaglandin E2 receptor binding. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4
Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate
recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with
PTGER4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the FEM1A gene promoter:
         Pax-5   SREBP-1c   Lmo2   AP-4   SREBP-1b   YY1   E2F-1   SREBP-1a   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FEM1A promoter sequence
   Search Chromatin IP Primers for FEM1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FEM1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FEM1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FEM1A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004791:  view genomic region     (about GC identifiers)

Start:
4,791,728 bp from pter      End:
4,795,571 bp from pter
Size:
3,844 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4 (See protein sequence)
Recommended Name: Protein fem-1 homolog A  
Size: 669 amino acids; 73639 Da
Subunit: Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4
Secondary accessions: B2RDI3 Q711P8 Q9NPN7 Q9NPW8

Explore the universe of human proteins at neXtProt for FEM1A: NX_Q9BSK4

Explore proteomics data for FEM1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys182, Lys206, Lys320
  • Modification sites at PhosphoSitePlus

  • See FEM1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061178.1  
    ENSEMBL proteins: 
     ENSP00000269856  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BSK4

    ProtoNet protein and cluster: Q9BSK4

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4
    Similarity: Belongs to the fem-1 family
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 2 TPR repeats


    Find genes that share domains with FEM1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FEM1A_HUMAN, Q9BSK4
    Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate
    recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with
    PTGER4
    Induction: Frequently down-regulated in rhabdomyosarcoma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0031867EP4 subtype prostaglandin E2 receptor binding IPI16424369
         
    Find genes that share ontologies with FEM1A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FEM1A
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    hsa-mir-423-3p (MIRT042591), hsa-mir-504-5p (MIRT041076), hsa-mir-760 (MIRT036724), hsa-mir-484 (MIRT042261)

    Block miRNA regulation of human, mouse, rat FEM1A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FEM1A:
    hsa-miR-135b hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidFEM1A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FEM1A_HUMAN, Q9BSK4: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    cytoskeleton1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with FEM1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FEM1A
    Interactions:

        GeneGlobe Interaction Network for FEM1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FEM1A (Q9BSK43 ENSP000002698564) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPM1FP495933, ENSP000002632124I2D: score=1 STRING: ENSP00000263212
    TCEAL1Q151703, ENSP000003617074I2D: score=2 STRING: ENSP00000361707
    UBCENSP000003448184STRING: ENSP00000344818
    KIAA0319ENSP000003674594STRING: ENSP00000367459
    PPM1EENSP000003124114STRING: ENSP00000312411
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050728negative regulation of inflammatory response IDA16424369
    GO:0051438regulation of ubiquitin-protein ligase activity ISS--

    Find genes that share ontologies with FEM1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FEM1A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FEM1A gene: 
    NM_018708.2  

    Unigene Cluster for FEM1A:

    Fem-1 homolog a (C. elegans)
    Hs.515082  [show with all ESTs]
    Unigene Representative Sequence: NM_018708
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000269856(uc002mbf.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FEM1A:
    hsa-miR-135b hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidFEM1A 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FEM1A
      QuantiTect SYBR Green Assays in human, mouse, rat FEM1A
      QuantiFast Probe-based Assays in human, mouse, rat FEM1A

    Additional mRNA sequence: 

    AJ311359.1 AK074232.1 AK126532.1 AK315554.1 AL359589.1 AL365408.1 AY356352.1 BC004988.1 
    CR749732.1 

    7 DOTS entries:

    DT.444040  DT.101981831  DT.75159514  DT.95090716  DT.95303560  DT.95090712  DT.95090715 

    Selected AceView cDNA sequences (see all 31):

    BF447595 AI219669 BE855928 AA932849 AA731842 BQ340183 BM553222 AK126532 
    CA311661 AA883966 AI951558 AI698736 BM916748 AW175962 AW804491 AA829913 
    AI245065 AI220002 AW754454 BM557537 AW970630 BF815454 BM551439 BF816198 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FEM1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAGTCTCC
    FEM1A Expression
    About this image


    FEM1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Skeletal Muscle (Muscoskeletal System)
    FEM1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FEM1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515082

    UniProtKB/Swiss-Prot: FEM1A_HUMAN, Q9BSK4
    Tissue specificity: Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at
    protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FEM1A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fem1a1 , 5 feminization 1 homolog a (C. elegans)1, 5 83.84(n)1
    91.59(a)1
      17 (29.24 cM)5
    141541  NM_010192.41  NP_034322.31 
     562567935 
    chicken
    (Gallus gallus)
    Aves FEM1A1 fem-1 homolog a (C. elegans) 74.29(n)
    81.65(a)
      420157  XM_418271.4  XP_418271.3 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi20c042 wufi20c04 77.53(n)   327613  BC060522.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69663   -- 49(a)
    (best of 2)
      88E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea fem-13 Expression: all somatic, embryo, L1
    larva, L2 more
    39(a)   IV(5533595-5538047)   --


    ENSEMBL Gene Tree for FEM1A (if available)
    TreeFam Gene Tree for FEM1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FEM1A gene
    TANC22  ANKRD172  ANKS32  ANKRD292  ANKHD12  FANK12  KIDINS2202  ANKHD1-EIF4EBP32  
    FEM1B2  TANC12  ANKS62  FEM1C2  
    2 SIMAP similar genes for FEM1A using alignment to 1 protein entry:     FEM1A_HUMAN:
    FEM1C    FEM1B

    Find genes that share paralogs with FEM1A           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for FEM1A
    PGOHUM00000248499 PGOHUM00000234877 PGOHUM00000239133 PGOHUM00000243331


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FEM1A (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504406361,2
    --4789755(+) GCGCGA/CTCTCG 1 -- us2k10--------
    rs116660541,2
    C,F,H--4789861(+) aatttC/Tttgta 1 -- us2k14Minor allele frequency- T:0.50NA 8
    rs116688311,2
    C,F,H--4789873(+) ttttaA/Gtagag 1 -- us2k15Minor allele frequency- G:0.40NA 10
    rs1432150841,2
    C--4789934(+) ATCCAC/GCCATC 1 -- us2k10--------
    rs72572811,2
    C,F,A--4789937(+) cacccA/Gtctcg 1 -- us2k17Minor allele frequency- G:0.46NA WA CSA 13
    rs1418209261,2
    C--4789990(+) CGGCCA/GGCATG 1 -- us2k10--------
    rs1462659901,2
    C--4790018(+) GAAGAC/TGCTGT 1 -- us2k10--------
    rs1932614361,2
    --4790131(+) GTCACC/GCAGGC 1 -- us2k10--------
    rs48076421,2
    C--4790420(+) TTGTAT/CATATA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs129743861,2
    C,F--4790442(+) ATAAAC/TTTTAA 1 -- us2k1 tfbs35Minor allele frequency- T:0.11NA EA 246

    HapMap Linkage Disequilibrium report for FEM1A (4791728 - 4795571 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FEM1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910847CNV Loss21882294
    nsv910859CNV Loss21882294

    Human Gene Mutation Database (HGMD): FEM1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FEM1A
    DNA2.0 Custom Variant and Variant Library Synthesis for FEM1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613538    OMIM disorders: --


    Find genes that share disorders with FEM1A           About GenesLikeMe

    Genetic Association Database (GAD): FEM1A
    Human Genome Epidemiology (HuGE) Navigator: FEM1A (7 documents)

    Export disorders for FEM1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FEM1A gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FEM1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FEM1A is a candidate gene for polycystic ovary syndrome. (PubMed id 16390781)1, 2, 4 Maher J.F.... Cowan B.D. (Gynecol. Endocrinol. 2005)
    2. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. (PubMed id 16424369)1, 2, 9 Takayama K.... Libby P. (Circ. Res. 2006)
    3. The Fem1a gene is downregulated in Rhabdomyosarcoma. (PubMed id 16254458)1, 2, 9 Ventura-Holman T.... Maher J.F. (Tumor Biol. 2005)
    4. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    7. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PubMed id 18757445)1, 4 Goodarzi M.O....Azziz R. (Hum. Reprod. 2008)
    8. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (Science 2001)
    9. [Polymorphisms of FEM1A gene in patients with polycystic ovary syndrome]. (PubMed id 22678803)1 Lin Y. and Sun Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55527 HGNC: 16934 AceView: FEM1A.1 Ensembl:ENSG00000141965 euGenes: HUgn55527
    ECgene: FEM1A H-InvDB: FEM1A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FEM1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FEM1A gene:
    Search GeneIP for patents involving FEM1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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