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Aliases for FEM1A Gene

Aliases for FEM1A Gene

  • Fem-1 Homolog A 2 3
  • Prostaglandin E Receptor 4-Associated Protein 3 4
  • Fem-1 Homolog A (C. Elegans) 2 5
  • FEM1-Alpha 3 4
  • EPRAP 3 4
  • FEM1a 4

External Ids for FEM1A Gene

Previous GeneCards Identifiers for FEM1A Gene

  • GC19P004883
  • GC19P004732
  • GC19P004742
  • GC19P004553

Summaries for FEM1A Gene

GeneCards Summary for FEM1A Gene

FEM1A (Fem-1 Homolog A) is a Protein Coding gene. Diseases associated with FEM1A include rhabdomyosarcoma. GO annotations related to this gene include ubiquitin-protein transferase activity and EP4 subtype prostaglandin E2 receptor binding. An important paralog of this gene is FEM1B.

UniProtKB/Swiss-Prot for FEM1A Gene

  • Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1A Gene

Genomics for FEM1A Gene

Regulatory Elements for FEM1A Gene

Promoters for FEM1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FEM1A on UCSC Golden Path with GeneCards custom track

Genomic Location for FEM1A Gene

Chromosome:
19
Start:
4,791,681 bp from pter
End:
4,801,273 bp from pter
Size:
9,593 bases
Orientation:
Plus strand

Genomic View for FEM1A Gene

Genes around FEM1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1A Gene

Proteins for FEM1A Gene

  • Protein details for FEM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK4-FEM1A_HUMAN
    Recommended name:
    Protein fem-1 homolog A
    Protein Accession:
    Q9BSK4
    Secondary Accessions:
    • B2RDI3
    • Q711P8
    • Q9NPN7
    • Q9NPW8

    Protein attributes for FEM1A Gene

    Size:
    669 amino acids
    Molecular mass:
    73639 Da
    Quaternary structure:
    • Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.

neXtProt entry for FEM1A Gene

Proteomics data for FEM1A Gene at MOPED

Post-translational modifications for FEM1A Gene

  • Ubiquitination at Lys 21, Lys 182, Lys 206, and Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FEM1A Gene

Domains & Families for FEM1A Gene

Gene Families for FEM1A Gene

Protein Domains for FEM1A Gene

Suggested Antigen Peptide Sequences for FEM1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSK4

UniProtKB/Swiss-Prot:

FEM1A_HUMAN :
  • Belongs to the fem-1 family.
  • Contains 9 ANK repeats.
Family:
  • Belongs to the fem-1 family.
Similarity:
  • Contains 9 ANK repeats.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with FEM1A: view

Function for FEM1A Gene

Molecular function for FEM1A Gene

UniProtKB/Swiss-Prot Function:
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.
UniProtKB/Swiss-Prot Induction:
Frequently down-regulated in rhabdomyosarcoma.

Gene Ontology (GO) - Molecular Function for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
genes like me logo Genes that share ontologies with FEM1A: view
genes like me logo Genes that share phenotypes with FEM1A: view

Animal Model Products

miRNA for FEM1A Gene

miRTarBase miRNAs that target FEM1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEM1A Gene

Localization for FEM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FEM1A Gene COMPARTMENTS Subcellular localization image for FEM1A gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FEM1A Gene

Pathways & Interactions for FEM1A Gene

SuperPathways for FEM1A Gene

No Data Available

UniProtKB/Swiss-Prot Q9BSK4-FEM1A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0050728 negative regulation of inflammatory response IDA 16424369
genes like me logo Genes that share ontologies with FEM1A: view

No data available for Pathways by source and SIGNOR curated interactions for FEM1A Gene

Drugs & Compounds for FEM1A Gene

No Compound Related Data Available

Transcripts for FEM1A Gene

mRNA/cDNA for FEM1A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FEM1A Gene

Fem-1 homolog a (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1A Gene

No ASD Table

Relevant External Links for FEM1A Gene

GeneLoc Exon Structure for
FEM1A
ECgene alternative splicing isoforms for
FEM1A

Expression for FEM1A Gene

mRNA expression in normal human tissues for FEM1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEM1A Gene

This gene is overexpressed in Muscle - Skeletal (x20.8).

Protein differential expression in normal tissues from HIPED for FEM1A Gene

This gene is overexpressed in Adrenal (40.1) and Plasma (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FEM1A Gene



SOURCE GeneReport for Unigene cluster for FEM1A Gene Hs.515082

mRNA Expression by UniProt/SwissProt for FEM1A Gene

Q9BSK4-FEM1A_HUMAN
Tissue specificity: Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
genes like me logo Genes that share expression patterns with FEM1A: view

Protein tissue co-expression partners for FEM1A Gene

Primer Products

In Situ Assay Products

Orthologs for FEM1A Gene

This gene was present in the common ancestor of animals.

Orthologs for FEM1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEM1A 36
  • 100 (a)
OneToOne
FEM1A 35
  • 99.25 (n)
  • 99.4 (a)
cow
(Bos Taurus)
Mammalia FEM1A 36
  • 96 (a)
OneToOne
FEM1A 35
  • 90.05 (n)
  • 95.41 (a)
dog
(Canis familiaris)
Mammalia FEM1A 35
  • 89.64 (n)
  • 95.17 (a)
mouse
(Mus musculus)
Mammalia 4931440F15Rik 36
  • 86 (a)
OneToMany
Fem1a 36
  • 91 (a)
OneToMany
Fem1a 16
Fem1a 35
  • 83.84 (n)
  • 91.59 (a)
oppossum
(Monodelphis domestica)
Mammalia FEM1A 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FEM1A 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fem1a 35
  • 82.72 (n)
  • 91.28 (a)
chicken
(Gallus gallus)
Aves FEM1A 35
  • 74.29 (n)
  • 81.65 (a)
FEM1A 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fem1a 36
  • 73 (a)
OneToOne
fem1a 35
  • 74.96 (n)
  • 75.12 (a)
wufi20c04 35
fruit fly
(Drosophila melanogaster)
Insecta CG11896 37
  • 30 (a)
CG6966 37
  • 49 (a)
CG6966 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fem-1 36
  • 33 (a)
OneToMany
fem-1 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for FEM1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FEM1A Gene

ENSEMBL:
Gene Tree for FEM1A (if available)
TreeFam:
Gene Tree for FEM1A (if available)

Paralogs for FEM1A Gene

Paralogs for FEM1A Gene

(2) SIMAP similar genes for FEM1A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FEM1A Gene

genes like me logo Genes that share paralogs with FEM1A: view

Variants for FEM1A Gene

Sequence variations from dbSNP and Humsavar for FEM1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3181004 -- 4,795,555(+) TCAAA(A/G)AGAAT utr-variant-3-prime
rs4807642 -- 4,790,408(+) TTGTA(C/T)ATATA upstream-variant-2KB
rs11085099 -- 4,794,245(+) AGGAC(A/G/T)GTCTG utr-variant-3-prime
rs11668831 -- 4,789,861(+) tttta(A/G)tagag upstream-variant-2KB
rs12974386 -- 4,790,430(+) ATAAA(C/T)TTTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FEM1A Gene

Variant ID Type Subtype PubMed ID
nsv910847 CNV Loss 21882294
nsv910859 CNV Loss 21882294

Variation tolerance for FEM1A Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FEM1A Gene

HapMap Linkage Disequilibrium report
FEM1A
Human Gene Mutation Database (HGMD)
FEM1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1A Gene

Disorders for FEM1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FEM1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search FEM1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for FEM1A

Genetic Association Database (GAD)
FEM1A
Human Genome Epidemiology (HuGE) Navigator
FEM1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FEM1A
genes like me logo Genes that share disorders with FEM1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FEM1A Gene

Publications for FEM1A Gene

  1. FEM1A is a candidate gene for polycystic ovary syndrome. (PMID: 16390781) Maher J.F. … Cowan B.D. (Gynecol. Endocrinol. 2005) 3 4 48 67
  2. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. (PMID: 16424369) Takayama K. … Libby P. (Circ. Res. 2006) 3 23
  3. The Fem1a gene is downregulated in Rhabdomyosarcoma. (PMID: 16254458) Ventura-Holman T. … Maher J.F. (Tumor Biol. 2005) 3 23
  4. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for FEM1A Gene

Sources for FEM1A Gene

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