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Aliases for FECH Gene

Aliases for FECH Gene

  • Ferrochelatase 2 3
  • Protoheme Ferro-Lyase 3 4
  • Protoporphyria 2 3
  • Heme Synthase 3 4
  • EC 4 63
  • FCE 3 6
  • Ferrochelatase (Protoporphyria) 2
  • Ferrochelatase, Mitochondrial 3
  • Heme Synthetase 3
  • EPP 3

External Ids for FECH Gene

Previous GeneCards Identifiers for FECH Gene

  • GC18P055578
  • GC18M055191
  • GC18M055001
  • GC18M053365
  • GC18M053367
  • GC18M051922

Summaries for FECH Gene

Entrez Gene Summary for FECH Gene

  • The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]

GeneCards Summary for FECH Gene

FECH (Ferrochelatase) is a Protein Coding gene. Diseases associated with FECH include protoporphyria, erythropoietic, autosomal recessive and x-linked protoporphyria. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include heme binding and ferrous iron binding.

UniProtKB/Swiss-Prot for FECH Gene

  • Catalyzes the ferrous insertion into protoporphyrin IX

Gene Wiki entry for FECH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FECH Gene

Genomics for FECH Gene

Regulatory Elements for FECH Gene

Genomic Location for FECH Gene

57,544,841 bp from pter
57,586,772 bp from pter
41,932 bases
Minus strand

Genomic View for FECH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FECH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FECH Gene

Proteins for FECH Gene

  • Protein details for FECH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferrochelatase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8KA72
    • Q8IXN1
    • Q8NAN0

    Protein attributes for FECH Gene

    423 amino acids
    Molecular mass:
    47862 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 1 [2Fe-2S] cluster.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for FECH Gene

    Alternative splice isoforms for FECH Gene


neXtProt entry for FECH Gene

Proteomics data for FECH Gene at MOPED

Post-translational modifications for FECH Gene

  • Ubiquitination at Lys57 and Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for FECH Gene

Domains for FECH Gene

Protein Domains for FECH Gene

Suggested Antigen Peptide Sequences for FECH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ferrochelatase family.
  • Belongs to the ferrochelatase family.
genes like me logo Genes that share domains with FECH: view

No data available for Gene Families for FECH Gene

Function for FECH Gene

Molecular function for FECH Gene

GENATLAS Biochemistry:
ferrochelatase,inner mitochondrial membrane,catalyzing heme formation,from protoporphyrin
UniProtKB/Swiss-Prot CatalyticActivity:
Protoheme + 2 H(+) = protoporphyrin + Fe(2+)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by nitric oxide (NO). The 2Fe-2S cluster could act as a NO sensor
UniProtKB/Swiss-Prot Function:
Catalyzes the ferrous insertion into protoporphyrin IX

Enzyme Numbers (IUBMB) for FECH Gene

Gene Ontology (GO) - Molecular Function for FECH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004325 ferrochelatase activity TAS --
GO:0005506 iron ion binding --
GO:0005515 protein binding IPI 15123683
GO:0008198 ferrous iron binding TAS 1729699
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with FECH: view
genes like me logo Genes that share phenotypes with FECH: view

Animal Models for FECH Gene

MGI Knock Outs for FECH:

miRNA for FECH Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FECH

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for FECH Gene

Localization for FECH Gene

Subcellular locations from UniProtKB/Swiss-Prot for FECH Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Jensen Localization Image for FECH Gene COMPARTMENTS Subcellular localization image for FECH gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FECH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FECH: view

Pathways for FECH Gene

genes like me logo Genes that share pathways with FECH: view

UniProtKB/Swiss-Prot P22830-HEMH_HUMAN

  • Pathway: Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1

Gene Ontology (GO) - Biological Process for FECH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 1729699
GO:0006778 porphyrin-containing compound metabolic process TAS --
GO:0006779 porphyrin-containing compound biosynthetic process --
GO:0006783 heme biosynthetic process TAS --
GO:0008203 cholesterol metabolic process IEA --
genes like me logo Genes that share ontologies with FECH: view

Compounds for FECH Gene

(1) Drugbank Compounds for FECH Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Cholic Acid
81-25-4 221493 Target approved

(3) HMDB Compounds for FECH Gene

Compound Synonyms Cas Number PubMed IDs
  • Formyl coenzyme A
  • (protoporphyrinato)iron
Protoporphyrin IX
  • 3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionate

(36) Novoseek inferred chemical compound relationships for FECH Gene

Compound -log(P) Hits PubMed IDs
protoporphyrin ix 96.2 120
n-methylmesoporphyrin 90.3 6
ppix 86.9 17
haem 86.6 39
mesoporphyrin 85.7 2
genes like me logo Genes that share compounds with FECH: view

Transcripts for FECH Gene

Unigene Clusters for FECH Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FECH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FECH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for FECH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FECH Gene

mRNA expression in normal human tissues for FECH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FECH Gene

SOURCE GeneReport for Unigene cluster for FECH Gene Hs.365365

genes like me logo Genes that share expressions with FECH: view

Expression partners for FECH Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FECH Gene

Orthologs for FECH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FECH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FECH 35
  • 86.14 (n)
  • 87.26 (a)
  • 87 (a)
(Canis familiaris)
Mammalia FECH 35
  • 88.95 (n)
  • 90.89 (a)
  • 86 (a)
(Mus musculus)
Mammalia Fech 35
  • 86.9 (n)
  • 88.7 (a)
Fech 16
Fech 36
  • 89 (a)
(Pan troglodytes)
Mammalia FECH 35
  • 99.37 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Fech 35
  • 87.28 (n)
  • 88.39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
-- 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia FECH 36
  • 92 (a)
(Gallus gallus)
Aves FECH 35
  • 76.76 (n)
  • 83.72 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia FECH 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fech 35
  • 75.46 (n)
  • 85.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398014 35
(Danio rerio)
Actinopterygii fech 35
  • 72.39 (n)
  • 79.56 (a)
fech 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta ferrochelatase 37
  • 55 (a)
ferrochelatase 35
  • 59.23 (n)
  • 56.21 (a)
ferrochelatase 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003719 35
  • 59.04 (n)
  • 57.34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR272W 35
  • 55.92 (n)
  • 53.43 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20141g 35
  • 54.73 (n)
  • 51.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HEM15 35
  • 55.13 (n)
  • 52.37 (a)
HEM15 36
  • 46 (a)
HEM15 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FC2 35
  • 49.79 (n)
  • 45.22 (a)
(Oryza sativa)
Liliopsida Os05g0361200 35
  • 49.15 (n)
  • 45.19 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8424 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08291 35
  • 58.26 (n)
  • 57.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hem15 35
  • 52.23 (n)
  • 49.57 (a)
Species with no ortholog for FECH:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FECH Gene

Gene Tree for FECH (if available)
Gene Tree for FECH (if available)

Paralogs for FECH Gene

(1) SIMAP similar genes for FECH Gene using alignment to 7 proteins: Pseudogenes for FECH Gene

genes like me logo Genes that share paralogs with FECH: view

No data available for Paralogs for FECH Gene

Variants for FECH Gene

Sequence variations from dbSNP and Humsavar for FECH Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs8339 -- 57,550,464(-) TCCAT(C/T)AGGAC utr-variant-3-prime
rs13271 -- 57,549,820(-) ATTAT(C/T)TTATA utr-variant-3-prime
rs13732 -- 57,545,084(-) CCCTG(A/C)GGGTC utr-variant-3-prime
rs317805 -- 57,582,307(+) attgg(A/T)gcatt intron-variant
rs317806 -- 57,583,032(+) ATGTC(C/T)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FECH Gene

Variant ID Type Subtype PubMed ID
esv2751777 CNV Gain 17911159
nsv458086 CNV Gain 19166990
nsv909663 CNV Gain 21882294
nsv833663 CNV Gain 17160897
nsv909664 CNV Loss 21882294

Relevant External Links for FECH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FECH Gene

Disorders for FECH Gene

(1) OMIM Diseases for FECH Gene (612386)


  • Erythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. {ECO:0000269 PubMed:10942404, ECO:0000269 PubMed:11375302, ECO:0000269 PubMed:12063482, ECO:0000269 PubMed:12601550, ECO:0000269 PubMed:1376018, ECO:0000269 PubMed:15286165, ECO:0000269 PubMed:17196862, ECO:0000269 PubMed:1755842, ECO:0000269 PubMed:7910885, ECO:0000269 PubMed:8757534, ECO:0000269 PubMed:9585598, ECO:0000269 PubMed:9740232}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(21) Novoseek inferred disease relationships for FECH Gene

Disease -log(P) Hits PubMed IDs
protoporphyria erythropoietic 98.5 129
skin photosensitivity 86.9 12
porphyria 82.7 4
porphyria, congenital erythropoietic 82.2 9
porphyria variegate 75.8 1

Relevant External Links for FECH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FECH: view

No data available for Genatlas for FECH Gene

Publications for FECH Gene

  1. Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase. (PMID: 2260980) Nakahashi Y. … Tokunaga R. (Biochem. Biophys. Res. Commun. 1990) 3 4 23
  2. Human erythropoietic protoporphyria: two point mutations in the ferrochelatase gene. (PMID: 1755842) Lamoril J. … Deybach J.-C. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  3. Recessive inheritance of erythropoietic protoporphyria with liver failure. (PMID: 7910885) Sarkany R.P.E. … Cox T.M. (Lancet 1994) 3 4 23
  4. Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases. (PMID: 8276824) Dailey H.A. … Dailey T.A. (J. Biol. Chem. 1994) 3 4 23
  5. A novel mutation in the ferrochelatase gene associated with erythropoietic protoporphyria. (PMID: 8757534) Imoto S. … Oka Y. (Br. J. Haematol. 1996) 3 4 23

Products for FECH Gene

Sources for FECH Gene

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