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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FDXR Gene

protein-coding   GIFtS: 63
GCID: GC17M072858

ferredoxin reductase


(Previous symbol: ADXR)
 Explore 14 diseases affiliated with
FDXR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FDXR    

Aliases
for FDXR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ferredoxin Reductase1 2 3     AR2 3
ADXR1 2 3 5     NADPH:Adrenodoxin Oxidoreductase, Mitochondrial2
Adrenodoxin Reductase2 3     EC 1.18.1.63
Ferredoxin--NADP(+) Reductase2 3     EC 1.18.1.28

External Ids:    HGNC: 36421   Entrez Gene: 22322   Ensembl: ENSG000001615137   OMIM: 1032705   UniProtKB: P225703   

Export aliases for FDXR gene to outside databases

Previous GC identifers: GC17M072875 GC17M075917 GC17M073322 GC17M073455 GC17M070370 GC17M068269


Summaries
for FDXR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FDXR:
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving
electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. (provided by
RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol
side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin
D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver

summary for FDXR:
Androgen receptors (ARs) (also known as dihydrotestosterone receptors) are nuclear hormone receptors of the
NR3C class, which also includes mineralocorticoid, progesterone and glucocorticoid receptors. They are
expressed in bone marrow, mammary gland, prostate, testicular and muscle tissues where they exist as dimers
coupled to Hsp90 and HMGB proteins, which are shed upon ligand binding. Activated androgen receptors bind to
nuclear response elements of the genome, with an inverted palindromic 15 nucleotide sequence, to regulate
gene transcription. Androgen receptors also effect gene expression through interaction with transcription
factors including AP-1, NF-kappaB and STAT. Target genes of androgen receptors include insulin-like growth
factor 1 (IGF-1) and genes involved in the development of primary and secondary male sexual characteristics,
maintenance of sexual function and possibly have a causative role in aggressive behavior. Furthermore,
androgen receptors have recently been shown to have actions that are independent of DNA interactions.
Congential mutations in androgen receptors are associated with androgen insensitivity syndromes, virility
and spinal and bulbar muscular atrophy. Perturbations in androgen receptor expression is also a common
feature of prostate cancer. The human gene encoding the androgen receptor has been localized to Xq11-12.

Gene Wiki entry for FDXR


Genomic Views
for FDXR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FDXR gene promoter:
         NRSF form 1   HNF-4alpha2   Tal-1beta   NRSF form 2   E47   HNF-4alpha1   MZF-1   AREB6   SEF-1 (1)   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FDXR promoter sequence
   Search SABiosciences Chromatin IP Primers for FDXR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDXR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24-q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q24-q25

FDXR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDXR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072858:  view genomic region     (about GC identifiers)

Start:
 72,858,619 bp from pter      End:
 72,869,156 bp from pter
Size:
 10,538 bases      Orientation:
 minus strand

Proteins
for FDXR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570 (See protein sequence)
Recommended Name: NADPH:adrenodoxin oxidoreductase, mitochondrial precursor  
Size: 491 amino acids; 53837 Da
Cofactor: FAD
Subunit: Monomer. Interacts directly with FDX1 (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: B4DHX5 Q13716 Q4PJI0 Q9BU12
Alternative splicing: 3 isoforms:  P22570-1   P22570-2   P22570-3   (Represents 10-20% of all adrenodoxin reductase mRNAs and seems to be inactive)

Explore the universe of human proteins at neXtProt for FDXR: NX_P22570

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22570

    • 4/10 DME Specific Peptides for FDXR (P22570) (see all 10)
     GVAPDHP  VGRRGPLQ  FTIKELRE  PVSFSDWEK 

    FDXR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001244941.1  NP_001244942.1  NP_001244943.1  NP_001244944.1  NP_001244945.1  NP_004101.2  NP_077728.2  

    ENSEMBL proteins: 
     ENSP00000464670   ENSP00000293195   ENSP00000445432   ENSP00000414172   ENSP00000462972  
     ENSP00000461993   ENSP00000462083   ENSP00000463940   ENSP00000416515   ENSP00000462183  
     ENSP00000408595   ENSP00000462884   ENSP00000463308   ENSP00000462330   ENSP00000462488  
     ENSP00000463934   ENSP00000390875  
    Reactome Protein details: P22570
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: FDXR
    OriGene Protein Over-expression Lysate: FDXR
    OriGene Custom Protein Services for FDXR 
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    Novus Biologicals FDXR Proteins
    Novus Biologicals FDXR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FDXR

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS2845396
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix IEA--


    FDXR for ontologies           About GeneDecksing



    FDXR Antibody Products: 
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    Uscn Antibodies for FDXR
    ThermoFisher Antibodies for FDXR

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    Uscn ELISAs and CLIAs for FDXR

    Protein Domains /
    Families
    for FDXR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FDXR for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021163 Adrenodoxin_Rdtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P22570

    ProtoNet protein and cluster: P22570

    2 Blocks protein families:
    IPB000759 Adrenodoxin reductase family signature
    IPB013027 FAD-dependent pyridine nucleotide reductase signature


    UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Similarity: Belongs to the ferredoxin--NADP reductase type 1 family


    Function
    for FDXR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol
    side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin
    D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver
    Catalytic activity: 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH

         Genatlas biochemistry entry for FDXR:
    ferredoxin oxidoreductase,electron transport flavoprotein for mitochondrial P450s

    Enzyme Numbers (IUBMB): EC 1.18.1.22 EC 1.18.1.61

    miRNA
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    hsa-mir-488 (MIRT003789)

    OriGene 3'-UTR Clone (see all 2): FDXR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDXR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FDXR
    SwitchGear 3'UTR luciferase reporter plasmid: FDXR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FDXR (see all 7)
    OriGene shRNA RFP: FDXR
    OriGene siRNA: FDXR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDXR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FDXR

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDXR (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FDXR (NM_024417)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDXR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDXR 

    Cell Line
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    Search LifeMap BioReagents cell lines for FDXR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDXR

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004324ferredoxin-NADP+ reductase activity TAS2845396
    GO:0005515protein binding IPI18319262
    GO:0015039NADPH-adrenodoxin reductase activity IEA--
    GO:0016491oxidoreductase activity ----


    FDXR for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FDXR:
     Decreased Salmonella enterica  


    Pathways & Interactions
    for FDXR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Iron-Sulfur Cluster Biogenesis
    		Mitochondrial Iron-Sulfur Cluster Biogenesis1.00
    		Electron Transport from NADPH to Ferredoxin0.33
    2Direct p53 effectors
    		Direct p53 effectors1.00
    3Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for FDXR 
        Direct p53 effectors

    3        Reactome Pathways for FDXR
        Mitochondrial Iron-Sulfur Cluster Biogenesis
    Metabolism
    Electron Transport from NADPH to Ferredoxin


    UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Pathway: Steroid metabolism; cholesterol metabolism


    FDXR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FDXR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for FDXR (P225701, 3 ENSP000002931954) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHITP497891, 3, ENSP000003420874EBI-1751533,EBI-741760 I2D: score=2 STRING: ENSP00000342087
    FDX1P101093, ENSP000002602704I2D: score=1 STRING: ENSP00000260270
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    CNOT1A5YKK63I2D: score=6 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2845396
    GO:0006694steroid biosynthetic process TAS1863359
    GO:0008203cholesterol metabolic process IEA--
    GO:0022900electron transport chain IEA--
    GO:0055114oxidation-reduction process TAS2845396


    FDXR for ontologies           About GeneDecksing



    Drugs & Compounds
    for FDXR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FDXR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for FDXR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NilutamideAndrogen receptor antagonist. Orally active[63612-50-0]
    BicalutamideNon-steroidal androgen receptor antagonist[90357-06-5]
    Cl-4AS-1Steroidal androgen receptor agonist[188589-66-4]
    FinasterideType II 5alpha-reductase inhibitor[98319-26-7]
    TFM-4AS-1Selective androgen receptor modulator (SARM)--

    3 HMDB Compounds for FDXR    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 DrugBank Compounds for FDXR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--10592235

    10/26 Novoseek chemical compound relationships for FDXR gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbazole 79.5 8 17554172 (2), 16511100 (1), 20516607 (1), 17161368 (1) (see all 5)
    putidaredoxin 72 3 9675270 (1), 17144670 (1)
    nadph 69.9 34 2403337 (2), 2294024 (2), 2078639 (1), 8251942 (1) (see all 23)
    iron-sulfur 64.2 4 8425475 (1), 8517924 (1), 1567230 (1), 7588394 (1)
    nadp+ 61.7 6 2236061 (1), 17635583 (1), 1315050 (1)
    steroid 58.6 14 11841224 (2), 10498693 (1), 11053423 (1), 1425418 (1) (see all 11)
    cholesterol 54 16 1425418 (2), 9029712 (1), 12787114 (1), 9818721 (1) (see all 13)
    flavin 53.7 2 8662973 (1)
    doca 53.1 1 10720486 (1)
    isoalloxazine 51.3 1 11053423 (1)

    Search CenterWatch for drugs/clinical trials and news about FDXR / ADRO 

    Transcripts
    for FDXR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FDXR gene (7 alternative transcripts): 
    NM_001258012.1  NM_001258013.1  NM_001258014.1  NM_001258015.1  NM_001258016.1  NM_004110.3  NM_024417.2  

    Unigene Cluster for FDXR:

    Ferredoxin reductase
    Hs.69745  [show with all ESTs]
    Unigene Representative Sequence: BC034763
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000583881 ENST00000293195(uc002jlx.3 uc002jly.3 uc010wrm.2 uc002jlz.3 uc002jmb.3)
    ENST00000544854(uc010wri.2) ENST00000420580 ENST00000578473(uc010wrj.2 uc002jlw.3 uc010wrk.2)
    ENST00000581530 ENST00000579482 ENST00000577509 ENST00000583917 ENST00000442102(uc010wrl.2)
    ENST00000582944 ENST00000413947 ENST00000582710 ENST00000579893 ENST00000580492
    ENST00000581969 ENST00000579543 ENST00000581219

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK098648.1 AK223530.1 AK293208.1 AK293210.1 AK295307.1 AK298908.1 AK301779.1 AK301977.1 
    BC002960.1 BC011521.1 BC018911.2 BC034763.1 BC063493.1 BT006684.1 J03826.1 NR_047576.1 

    16 DOTS entries:

    DT.310507  DT.100817682  DT.100817683  DT.100027359  DT.40132463  DT.97844056  DT.120927223  DT.120927273 
    DT.100817679  DT.100817684  DT.120927270  DT.97844058  DT.120927215  DT.120927220  DT.120927271  DT.100817680 

    24/162 AceView cDNA sequences (see all 162):

    BC002960 CR594512 BM554402 CB112384 BQ425924 BM477975 CB852815 BC034763 
    AI744077 BU149238 CR616367 BX402070 BU184028 CR619324 AI754779 BM467785 
    CF129986 AK098648 CR615445 BE745424 BM547494 CA395965 BX341485 BQ652928 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FDXR (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                      -                 -     -     -                                               -           -                           
    SP2:                                -     -                       -     -                                               -           -                           
    SP3:                          -     -     -                 -     -     -                                               -           -                           
    SP4:                          -     -     -                 -     -     -                                               -                                       
    SP5:                                -     -                 -     -     -                                               -           -                           

    ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for FDXR

    Expression
    for FDXR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FDXR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGAAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FDXR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FDXR

    SOURCE GeneReport for Unigene cluster: Hs.69745
        SABiosciences Custom PCR Arrays for FDXR
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    Orthologs
    for FDXR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for FDXR gene from 11/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fdxr1 , 5 ferredoxin reductase1, 5 85.74(n)1
    87.37(a)1    		   11 (80.84 cM)5
    141491  NM_007997.11  NP_032023.11 
     1152680245 
    chicken
    (Gallus gallus)    		 Aves FDXR1 ferredoxin reductase 68.92(n)
    69.28(a)    		   769635  XM_001232922.2  XP_001232923.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FDXR6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 2(115328519-115362750)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.89592 Xenopus laevis transcribed sequence with moderate similarity more 73.2(n)    BU905014.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005361151 NADPH:adrenodoxin oxidoreductase, mitochondrial-like 63.2(n)
    63.57(a)    		   100536115  XM_003199654.1  XP_003199702.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dare1 , 3 molting cycle (sensu Insecta) electron
    transporter3
    defective in the avoidance of repellents1    		 47(a)3
    56.23(n)1
    52.1(a)1    		   2 47E43
    362031  NM_057802.51  NP_477150.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y62E10A.63   -- 36(a)   IV(13372168-13377437)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ARH1(YDR376W)4
    ARH11    		 Oxidoreductase of the mitochondrial inner membrane, more4
    Arh1p1    		 42.79(n)1
    37.16(a)1    		   4(1226822-1228303)4
    8519821, 4  NP_010664.31  NP_010664.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G323601 ferredoxin--NADP+ reductase 50.52(n)
    49.33(a)    		   829370  NM_119388.4  NP_194962.2 
    rice
    (Oryza sativa)    		 Liliopsida Os02g02776001 hypothetical protein 52.27(n)
    50.91(a)    		   4329009  NM_001053082.1  NP_001046547.1 


    ENSEMBL Gene Tree for FDXR (if available)
    TreeFam Gene Tree for FDXR (if available) 

    Paralogs
    for FDXR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for FDXR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/319 NCBI SNPs in FDXR are shown (see all 319)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1924223121,2
    		--72858207(+) AGTGTA/GTCTGA 8 -- ds50010--------
    rs1157739501,2
    		F,--72858272(+) CTCGCC/GTGGGG 8 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1400078391,2
    		C,--72858300(+) GACAA-/GCTGCTTC
    TCAGTCCCCC    GCTCC     		8 -- ds50010--------
    rs1161915571,2
    		F,--72858375(+) GGTCCC/TGGTCC 8 -- ds50011Minor allele frequency- T:0.02WA 118
    rs356887631,2
    		C,F,--72858391(-) GGGCTG/TCCCGG 8 -- ds50016Minor allele frequency- T:0.04NS WA 302
    rs1399918151,2
    		--72858470(+) GCCAGA/GCCTGG 8 -- ds50010--------
    rs339490491,2
    		C,F,--72858493(-) TGGGG-/GCTTGA 8 -- ds50016Minor allele frequency- G:0.38NS CSA 186
    rs1848623391,2
    		--72858537(+) CGCCAC/TCTGGT 8 -- ds50010--------
    rs340158231,2
    		C,F,H,--72858591(-) TTTTGG/AAAGGG 8 -- ds50018Minor allele frequency- A:0.00EA NS NA 350
    rs1929281861,2
    		--72858620(+) TGGCTC/TTTGGT 8 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for FDXR (72858619 - 72869156 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FDXR: --

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    Disorders / Diseases
    for FDXR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FDXR for disorders           About GeneDecksing

    OMIM gene information: 103270    OMIM disorders: --

    14 diseases for FDXR:    About MalaCards
    spinal-bulbar muscular atrophy    lipoid adrenal hyperplasia    androgen insensitivity syndrome    adrenal hyperplasia
    muscular atrophy    locked-in syndrome    virilization    hypospadias
    toxoplasmosis    colorectal cancer    tuberculosis    cholesterol
    malaria    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for FDXR:
    locked-in syndrome     Congenital adrenal insufficiency

    4 Novoseek disease relationships for FDXR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 18.9 5 12614197 (2), 15863094 (1), 18767989 (1), 18293930 (1)
    colon cancer 0 3 11590433 (1), 14559799 (1)
    colorectal cancer 0 6 14559799 (3), 16528528 (2), 11590433 (1)
    tumors 0 16 16528528 (3), 19004824 (2), 14559799 (1), 14614330 (1)

    Human Genome Epidemiology (HuGE) Navigator: FDXR (1 document)

    Export disorders for FDXR gene to outside databases

    Publications
    for FDXR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FDXR gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with FDXR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence of the human adrenodoxin reductase gene. (PubMed id 2236061)1, 2, 9 Lin D.... Miller W.L. (1990)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen-->q25 are expressed in steroidogenic tissues. (PubMed id 2845396)1, 2 Solish S.B.... Miller W.L. (1988)
    5. Molecular cloning and sequence analysis of human placental ferredoxin. (PubMed id 2969697)1, 3 Mittal S.... Vickery L.E. (1988)
    6. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. (PubMed id 12370809)1, 9 Liu G. and Chen X. (2002)
    7. Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. (PubMed id 11053423)1, 9 Muller J.J....Heinemann U. (2001)
    8. Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. (PubMed id 19004824)1, 9 Pichiorri F....Huebner K. (2009)
    9. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. (PubMed id 1863359)1, 9 Sparkes R.S....Miller W.L. (1991)
    10. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. (PubMed id 18319262)1, 9 Trapasso F....Croce C.M. (2008)

    External Searches for FDXR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FDXR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2232 HGNC: 3642 AceView: FDXR Ensembl:ENSG00000161513 euGenes: HUgn2232
    ECgene: FDXR H-InvDB: FDXR

    Other Databases showing FDXR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FDXR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FDXR Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fdxr/

    Intellectual Property
    for FDXR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FDXR gene:
    Search GeneIP for patents involving FDXR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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