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FDXR Gene

protein-coding   GIFtS: 68
GCID: GC17M072858

Ferredoxin Reductase


(Previous symbol: ADXR)
  See FDXR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ferredoxin Reductase1 2 3     AR2 3
ADXR1 2 3 5     NADPH:Adrenodoxin Oxidoreductase, Mitochondrial2
Adrenodoxin Reductase1 2 3     EC 1.18.1.63
Adrenodoxin-NADP(+) Reductase1 2     EC 1.18.1.28
Ferredoxin--NADP(+) Reductase2 3     

External Ids:    HGNC: 36421   Entrez Gene: 22322   Ensembl: ENSG000001615137   OMIM: 1032705   UniProtKB: P225703   

Export aliases for FDXR gene to outside databases

Previous GC identifers: GC17M072875 GC17M075917 GC17M073322 GC17M073455 GC17M070370 GC17M068269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FDXR Gene:
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving
electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. (provided
by RefSeq, Apr 2012)

GeneCards Summary for FDXR Gene:
FDXR (ferredoxin reductase) is a protein-coding gene. Diseases associated with FDXR include congenital adrenal insufficiency, and locked-in syndrome. GO annotations related to this gene include NADPH-adrenodoxin reductase activity and NADPH binding.

UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including
cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal
cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver

summary for FDXR Gene:
Androgen receptors (ARs) (also known as dihydrotestosterone receptors) are nuclear hormone receptors of the
NR3C class, which also includes mineralocorticoid, progesterone and glucocorticoid receptors. They are
expressed in bone marrow, mammary gland, prostate, testicular and muscle tissues where they exist as dimers
coupled to Hsp90 and HMGB proteins, which are shed upon ligand binding. Activated androgen receptors bind to
nuclear response elements of the genome, with an inverted palindromic 15 nucleotide sequence, to regulate
gene transcription. Androgen receptors also effect gene expression through interaction with transcription
factors including AP-1, NF-kappaB and STAT. Target genes of androgen receptors include insulin-like growth
factor 1 (IGF-1) and genes involved in the development of primary and secondary male sexual characteristics,
maintenance of sexual function and possibly have a causative role in aggressive behavior. Furthermore,
androgen receptors have recently been shown to have actions that are independent of DNA interactions.
Congential mutations in androgen receptors are associated with androgen insensitivity syndromes, virility
and spinal and bulbar muscular atrophy. Perturbations in androgen receptor expression is also a common
feature of prostate cancer. The human gene encoding the androgen receptor has been localized to Xq11-12.

Gene Wiki entry for FDXR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FDXR gene promoter:
         NRSF form 1   HNF-4alpha2   Tal-1beta   NRSF form 2   E47   HNF-4alpha1   MZF-1   AREB6   SEF-1 (1)   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFDXR promoter sequence
   Search Chromatin IP Primers for FDXR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FDXR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

FDXR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDXR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072858:  view genomic region     (about GC identifiers)

Start:
72,858,619 bp from pter      End:
72,869,156 bp from pter
Size:
10,538 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570 (See protein sequence)
Recommended Name: NADPH:adrenodoxin oxidoreductase, mitochondrial precursor  
Size: 491 amino acids; 53837 Da
Cofactor: FAD
Subunit: Monomer. Interacts directly with FDX1 (By similarity)
Secondary accessions: B4DDI7 B4DHX5 B4DQQ4 B4DX24 B7Z7G2 E7EQC1 Q13716 Q4PJI0 Q9BU12
Alternative splicing: 7 isoforms:  P22570-1   P22570-2   P22570-3   P22570-4   P22570-5   P22570-6   P22570-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FDXR: NX_P22570

Explore proteomics data for FDXR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys209
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FDXR (P22570) (see all 10)
     GVAPDHP  VGRRGPLQ  FTIKELRE  PVSFSDWEK 


    See FDXR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001244941.1  NP_001244942.1  NP_001244943.1  NP_001244944.1  NP_001244945.1  NP_004101.2  NP_077728.2  

    ENSEMBL proteins: 
     ENSP00000464670   ENSP00000293195   ENSP00000445432   ENSP00000414172   ENSP00000462972  
     ENSP00000461993   ENSP00000462083   ENSP00000463940   ENSP00000416515   ENSP00000462183  
     ENSP00000408595   ENSP00000462884   ENSP00000463308   ENSP00000462330   ENSP00000462488  
     ENSP00000463934   ENSP00000390875  
    Reactome Protein details: P22570

    FDXR Human Recombinant Protein Products:

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    Novus Biologicals FDXR Proteins
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    Cloud-Clone Corp. Proteins for FDXR

     
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    antibodies-online proteins for FDXR (6 products) 

     
    antibodies-online peptides for FDXR

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    antibodies-online antibodies for FDXR (48 products) 

    FDXR Assay Products:

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    Cloud-Clone Corp. CLIAs for FDXR
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    antibodies-online kits for FDXR (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021163 Adrenodoxin_Rdtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P22570

    ProtoNet protein and cluster: P22570

    2 Blocks protein domains:
    IPB000759 Adrenodoxin reductase family signature
    IPB013027 FAD-dependent pyridine nucleotide reductase signature


    UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Similarity: Belongs to the ferredoxin--NADP reductase type 1 family


    Find genes that share domains with FDXR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADRO_HUMAN, P22570
    Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including
    cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal
    cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver
    Catalytic activity: 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH

         Genatlas biochemistry entry for FDXR:
    ferredoxin oxidoreductase,electron transport flavoprotein for mitochondrial P450s

         Enzyme Numbers (IUBMB): EC 1.18.1.22 EC 1.18.1.61

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004324ferredoxin-NADP+ reductase activity TAS2845396
    GO:0005515protein binding IPI18319262
    GO:0015039NADPH-adrenodoxin reductase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0070402NADPH binding IEA--
         
    Find genes that share ontologies with FDXR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FDXR:
     Decreased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FDXR

    miRNA
    Products:
        
    miRTarBase miRNAs that target FDXR:
    hsa-mir-501-3p (MIRT037989), hsa-mir-16-5p (MIRT031555), hsa-mir-26b-5p (MIRT029194), hsa-mir-500a-3p (MIRT041149)

    Block miRNA regulation of human, mouse, rat FDXR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FDXR
    SwitchGear 3'UTR luciferase reporter plasmidFDXR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FDXR

    Gene Editing
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    OriGene ORF clones in mouse, rat for FDXR
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    GenScript: all cDNA clones in your preferred vector (see all 2): FDXR (NM_024417)
    Sino Biological Human cDNA Clone for FDXR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDXR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDXR
    Addgene plasmids for FDXR 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDXR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADRO_HUMAN, P22570: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    nucleus2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with FDXR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FDXR About    
    See pathways by source

    SuperPathContained pathways About
    1Mitochondrial Iron-Sulfur Cluster Biogenesis
    Mitochondrial Iron-Sulfur Cluster Biogenesis
    Electron Transport from NADPH to Ferredoxin0.00
    2Metabolism
    Metabolism0.38
    3Direct p53 effectors
    Direct p53 effectors


    Find genes that share SuperPaths with FDXR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FDXR
        Androgen Signaling
    Akt Signaling

    1 BioSystems Pathway for FDXR
        Direct p53 effectors


    1 Reactome Pathway for FDXR
        Electron transport from NADPH to Ferredoxin


    UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Pathway: Steroid metabolism; cholesterol metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FDXR
    Interactions:

        GeneGlobe Interaction Network for FDXR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FDXR (P225701, 3 ENSP000002931954) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHITP497891, 3, ENSP000003420874EBI-1751533,EBI-741760 I2D: score=2 STRING: ENSP00000342087
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=6 
    FDX1P101093, ENSP000002602704I2D: score=1 STRING: ENSP00000260270
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2845396
    GO:0006694steroid biosynthetic process TAS1863359
    GO:0008203cholesterol metabolic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process TAS2845396

    Find genes that share ontologies with FDXR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FDXR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TestosteroneEndogenous androgen receptor agonist[58-22-0]
    FlutamideNon-steroidal androgen receptor antagonist[13311-84-7]
    NilutamideAndrogen receptor antagonist. Orally active[63612-50-0]
    BicalutamideNon-steroidal androgen receptor antagonist[90357-06-5]
    Cl-4AS-1Steroidal androgen receptor agonist[188589-66-4]

    3 HMDB Compounds for FDXR    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 DrugBank Compounds for FDXR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--10592235

    Selected Novoseek inferred chemical compound relationships for FDXR gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbazole 79.5 8 17554172 (2), 16511100 (1), 20516607 (1), 17161368 (1) (see all 5)
    putidaredoxin 72 3 9675270 (1), 17144670 (1)
    nadph 69.9 34 2403337 (2), 2294024 (2), 2078639 (1), 8251942 (1) (see all 23)
    iron-sulfur 64.2 4 8425475 (1), 8517924 (1), 1567230 (1), 7588394 (1)
    nadp+ 61.7 6 2236061 (1), 17635583 (1), 1315050 (1)
    steroid 58.6 14 11841224 (2), 10498693 (1), 11053423 (1), 1425418 (1) (see all 11)
    cholesterol 54 16 1425418 (2), 9029712 (1), 12787114 (1), 9818721 (1) (see all 13)
    flavin 53.7 2 8662973 (1)
    doca 53.1 1 10720486 (1)
    isoalloxazine 51.3 1 11053423 (1)



    Find genes that share compounds with FDXR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FDXR gene (7 alternative transcripts): 
    NM_001258012.2  NM_001258013.2  NM_001258014.2  NM_001258015.2  NM_001258016.2  NM_004110.4  NM_024417.3  

    Unigene Cluster for FDXR:

    Ferredoxin reductase
    Hs.69745  [show with all ESTs]
    Unigene Representative Sequence: BC034763
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000583881 ENST00000293195(uc002jlx.3 uc002jly.3 uc010wrm.2 uc002jlz.3 uc002jmb.3)
    ENST00000544854(uc010wri.2) ENST00000420580 ENST00000578473(uc010wrj.2 uc002jlw.3 uc010wrk.2)
    ENST00000581530 ENST00000579482 ENST00000577509 ENST00000583917 ENST00000442102(uc010wrl.2)
    ENST00000582944 ENST00000413947 ENST00000582710 ENST00000579893 ENST00000580492
    ENST00000581969 ENST00000579543 ENST00000581219
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      QuantiFast Probe-based Assays in human, mouse, rat FDXR

    Additional mRNA sequence: 

    AK098648.1 AK223530.1 AK293208.1 AK293210.1 AK295307.1 AK298908.1 AK301779.1 AK301977.1 
    BC002960.1 BC011521.1 BC018911.2 BC034763.1 BC063493.1 BT006684.1 J03826.1 NR_047576.1 

    16 DOTS entries:

    DT.310507  DT.100817682  DT.100817683  DT.100027359  DT.40132463  DT.97844056  DT.120927223  DT.120927273 
    DT.100817679  DT.100817684  DT.120927270  DT.97844058  DT.120927215  DT.120927220  DT.120927271  DT.100817680 

    Selected AceView cDNA sequences (see all 162):

    CR622927 BE745424 BC063493 AI754779 BM554402 C21050 BM702164 CR613827 
    AK098648 BQ652928 BI826616 AI744077 BQ707344 BC034763 CB852815 CB126298 
    BQ425924 BM477975 CR594512 CR615445 BU149238 CR616367 BX402070 BX363976 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FDXR (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                      -                 -     -     -                                               -           -                           
    SP2:                                -     -                       -     -                                               -           -                           
    SP3:                          -     -     -                 -     -     -                                               -           -                           
    SP4:                          -     -     -                 -     -     -                                               -                                       
    SP5:                                -     -                 -     -     -                                               -           -                           

    ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for FDXR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FDXR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAAATAA
    FDXR Expression
    About this image


    FDXR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    FDXR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FDXR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.69745
        Custom PCR Arrays for FDXR
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FDXR gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fdxr1 , 5 ferredoxin reductase1, 5 85.74(n)1
    87.37(a)1
      11 (80.84 cM)5
    141491  NM_007997.11  NP_032023.11 
     1152680245 
    chicken
    (Gallus gallus)
    Aves FDXR1 ferredoxin reductase 68.84(n)
    69.13(a)
      769635  XM_004946354.1  XP_004946411.1 
    lizard
    (Anolis carolinensis)
    Reptilia FDXR6
    ferredoxin reductase
    65(a)
    1 ↔ 1
    2(115318527-115362750)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89592 Xenopus laevis transcribed sequence with moderate similarity more 73.2(n)    BU905014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005361151 NADPH:adrenodoxin oxidoreductase, mitochondrial-like 63.14(n)
    63.74(a)
      100536115  XM_005169494.1  XP_005169551.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dare1 , 3 molting cycle (sensu Insecta) electron
    transporter3
    defective in the avoidance of repellents1
    47(a)3
    55.84(n)1
    51.64(a)1
      2 47E43
    362031  NM_057802.51  NP_477150.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y62E10A.63   -- 36(a)   IV(13372168-13377437)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARH1(YDR376W)4 Oxidoreductase of the mitochondrial inner membrane, more   --   4(1226822-1228303) 851982  NP_010664.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G323601 AT4G32360 51(n)
    49.89(a)
      829370  NM_119388.4  NP_194962.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g02776001 Os02g0277600 52.68(n)
    50.79(a)
      4329009  NM_001053082.1  NP_001046547.1 


    ENSEMBL Gene Tree for FDXR (if available)
    TreeFam Gene Tree for FDXR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FDXR (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924223121,2
    --72858207(+) AGTGTA/GTCTGA 8 -- ds50010--------
    rs1157739501,2
    F--72858272(+) CTCGCC/GTGGGG 8 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1400078391,2
    C--72858300(+) GACAA-/GCTGCTTC
    TCAGTCCCCC
    GCTCC
    8 -- ds50010--------
    rs1161915571,2
    C,F--72858375(+) GGTCCC/TGGTCC 8 -- ds50011Minor allele frequency- T:0.02WA 118
    rs356887631,2
    C,F--72858391(-) GGGCTG/TCCCGG 8 -- ds50016Minor allele frequency- T:0.04NS WA 302
    rs1399918151,2
    --72858470(+) GCCAGA/GCCTGG 8 -- ds50010--------
    rs1848623391,2
    --72858537(+) CGCCAC/TCTGGT 8 -- ds50010--------
    rs340158231,2
    C,F,H--72858591(-) TTTTGG/AAAGGG 8 -- ds50018Minor allele frequency- A:0.00EA NS NA 350
    rs1929281861,2
    --72858620(+) TGGCTC/TTTGGT 8 -- ut31 nc-transcript-variant0--------
    rs346074061,2
    C,F--72858709(-) TGGGCC/TGATCT 8 -- ut31 nc-transcript-variant6Minor allele frequency- T:0.03NS WA 302

    HapMap Linkage Disequilibrium report for FDXR (72858619 - 72869156 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FDXR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518292CNV Loss19592680
    nsv833540CNV Loss17160897
    dgv3253n71CNV Loss21882294
    nsv908744CNV Loss21882294
    dgv3254n71CNV Loss21882294
    nsv908743CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FDXR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103270    OMIM disorders: --

    4 diseases for FDXR:    
    About MalaCards
    congenital adrenal insufficiency    locked-in syndrome    lipoid adrenal hyperplasia    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for FDXR:
    locked-in syndrome     Congenital adrenal insufficiency

    Find genes that share disorders with FDXR           About GenesLikeMe

    4 Novoseek inferred disease relationships for FDXR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 18.9 5 12614197 (2), 15863094 (1), 18767989 (1), 18293930 (1)
    colon cancer 0 3 11590433 (1), 14559799 (1)
    colorectal cancer 0 6 14559799 (3), 16528528 (2), 11590433 (1)
    tumors 0 16 16528528 (3), 19004824 (2), 14559799 (1), 14614330 (1)

    Genetic Association Database (GAD): FDXR
    Human Genome Epidemiology (HuGE) Navigator: FDXR (1 document)

    Export disorders for FDXR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FDXR gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with FDXR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence of the human adrenodoxin reductase gene. (PubMed id 2236061)1, 2, 9 Lin D.... Miller W.L. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen-->q25 are expressed in steroidogenic tissues. (PubMed id 2845396)1, 2 Solish S.B.... Miller W.L. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    6. Molecular cloning and sequence analysis of human placental ferredoxin. (PubMed id 2969697)1, 3 Mittal S.... Vickery L.E. (Arch. Biochem. Biophys. 1988)
    7. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. (PubMed id 12370809)1, 9 Liu G. and Chen X. (Oncogene 2002)
    8. Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. (PubMed id 11053423)1, 9 MA1ller J.J....Heinemann U. (J. Biol. Chem. 2001)
    9. Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. (PubMed id 19004824)1, 9 Pichiorri F....Huebner K. (J. Biol. Chem. 2009)
    10. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. (PubMed id 1863359)1, 9 Sparkes R.S....Miller W.L. (DNA Cell Biol. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2232 HGNC: 3642 AceView: FDXR Ensembl:ENSG00000161513 euGenes: HUgn2232
    ECgene: FDXR H-InvDB: FDXR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FDXR Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fdxr/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FDXR gene:
    Search GeneIP for patents involving FDXR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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