Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FDXR Gene

protein-coding   GIFtS: 68
GCID: GC17M072858

Ferredoxin Reductase


(Previous symbol: ADXR)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ferredoxin Reductase1 2 3     AR2 3
ADXR1 2 3 5     NADPH:Adrenodoxin Oxidoreductase, Mitochondrial2
Adrenodoxin Reductase1 2 3     EC 1.18.1.63
Adrenodoxin-NADP(+) Reductase1 2     EC 1.18.1.28
Ferredoxin--NADP(+) Reductase2 3     

External Ids:    HGNC: 36421   Entrez Gene: 22322   Ensembl: ENSG000001615137   OMIM: 1032705   UniProtKB: P225703   

Export aliases for FDXR gene to outside databases

Previous GC identifers: GC17M072875 GC17M075917 GC17M073322 GC17M073455 GC17M070370 GC17M068269


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FDXR Gene:
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving
electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. (provided
by RefSeq, Apr 2012)

GeneCards Summary for FDXR Gene: 
FDXR (ferredoxin reductase) is a protein-coding gene. Diseases associated with FDXR include congenital adrenal insufficiency, and locked-in syndrome, and among its related super-pathways are Electron Transport from NADPH to Ferredoxin and Metabolic pathways. GO annotations related to this gene include NADPH-adrenodoxin reductase activity and NADPH binding.

UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including
cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal
cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver

summary for FDXR Gene:
Androgen receptors (ARs) (also known as dihydrotestosterone receptors) are nuclear hormone receptors of the
NR3C class, which also includes mineralocorticoid, progesterone and glucocorticoid receptors. They are
expressed in bone marrow, mammary gland, prostate, testicular and muscle tissues where they exist as dimers
coupled to Hsp90 and HMGB proteins, which are shed upon ligand binding. Activated androgen receptors bind to
nuclear response elements of the genome, with an inverted palindromic 15 nucleotide sequence, to regulate
gene transcription. Androgen receptors also effect gene expression through interaction with transcription
factors including AP-1, NF-kappaB and STAT. Target genes of androgen receptors include insulin-like growth
factor 1 (IGF-1) and genes involved in the development of primary and secondary male sexual characteristics,
maintenance of sexual function and possibly have a causative role in aggressive behavior. Furthermore,
androgen receptors have recently been shown to have actions that are independent of DNA interactions.
Congential mutations in androgen receptors are associated with androgen insensitivity syndromes, virility
and spinal and bulbar muscular atrophy. Perturbations in androgen receptor expression is also a common
feature of prostate cancer. The human gene encoding the androgen receptor has been localized to Xq11-12.

Gene Wiki entry for FDXR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FDXR gene promoter:
         NRSF form 1   HNF-4alpha2   Tal-1beta   NRSF form 2   E47   HNF-4alpha1   MZF-1   AREB6   SEF-1 (1)   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFDXR promoter sequence
   Search SABiosciences Chromatin IP Primers for FDXR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDXR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

FDXR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDXR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072858:  view genomic region     (about GC identifiers)

Start:
72,858,619 bp from pter      End:
72,869,156 bp from pter
Size:
10,538 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570 (See protein sequence)
Recommended Name: NADPH:adrenodoxin oxidoreductase, mitochondrial precursor  
Size: 491 amino acids; 53837 Da
Cofactor: FAD
Subunit: Monomer. Interacts directly with FDX1 (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: B4DDI7 B4DHX5 B4DQQ4 B4DX24 B7Z7G2 E7EQC1 Q13716 Q4PJI0 Q9BU12
Alternative splicing: 7 isoforms:  P22570-1   P22570-2   P22570-3   P22570-4   P22570-5   P22570-6   P22570-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FDXR: NX_P22570

Explore proteomics data for FDXR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22570

  • 4/10 DME Specific Peptides for FDXR (P22570) (see all 10)
     GVAPDHP  VGRRGPLQ  FTIKELRE  PVSFSDWEK 

    FDXR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FDXR Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001244941.1  NP_001244942.1  NP_001244943.1  NP_001244944.1  NP_001244945.1  NP_004101.2  NP_077728.2  

    ENSEMBL proteins: 
     ENSP00000464670   ENSP00000293195   ENSP00000445432   ENSP00000414172   ENSP00000462972  
     ENSP00000461993   ENSP00000462083   ENSP00000463940   ENSP00000416515   ENSP00000462183  
     ENSP00000408595   ENSP00000462884   ENSP00000463308   ENSP00000462330   ENSP00000462488  
     ENSP00000463934   ENSP00000390875  
    Reactome Protein details: P22570
    Human Recombinant Protein Products for FDXR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FDXR
    OriGene Protein Over-expression Lysate for FDXR
    OriGene MassSpec for FDXR 
    OriGene Custom Protein Services for FDXR
    GenScript Custom Purified and Recombinant Proteins Services for FDXR
    Novus Biologicals FDXR Proteins
    Novus Biologicals FDXR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FDXR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS2845396
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix TAS--

    FDXR for ontologies           About GeneDecksing



    FDXR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FDXR
    GenScript Custom Superior Antibodies Services for FDXR
    Novus Biologicals FDXR Antibodies
    Abcam antibodies for FDXR
    Cloud-Clone Corp. Antibodies for FDXR 
    ThermoFisher Antibodies for FDXR
    LSBio Antibodies in human, mouse, rat for FDXR 

    Assay Products for FDXR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FDXR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FDXR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FDXR 
    Cloud-Clone Corp. CLIAs for FDXR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021163 Adrenodoxin_Rdtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P22570

    ProtoNet protein and cluster: P22570

    2 Blocks protein domains:
    IPB000759 Adrenodoxin reductase family signature
    IPB013027 FAD-dependent pyridine nucleotide reductase signature


    UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Similarity: Belongs to the ferredoxin--NADP reductase type 1 family


    FDXR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADRO_HUMAN, P22570
    Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including
    cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal
    cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver
    Catalytic activity: 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH

         Genatlas biochemistry entry for FDXR:
    ferredoxin oxidoreductase,electron transport flavoprotein for mitochondrial P450s

         Enzyme Numbers (IUBMB): EC 1.18.1.22 EC 1.18.1.61

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004324ferredoxin-NADP+ reductase activity TAS2845396
    GO:0005515protein binding IPI18319262
    GO:0015039NADPH-adrenodoxin reductase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0070402NADPH binding IEA--
         
    FDXR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FDXR:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FDXR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FDXR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FDXR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FDXR 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FDXR:
    hsa-mir-488 (MIRT003789)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDXR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FDXR
    SwitchGear 3'UTR luciferase reporter plasmidFDXR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FDXR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDXR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FDXR
    Sirion Biotech Customized adenovirus for overexpression of FDXR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FDXR (see all 11)
    OriGene ORF clones in mouse, rat for FDXR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FDXR (NM_024417)
    Sino Biological Human cDNA Clone for FDXR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDXR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDXR
    Sirion Biotech Customized lentivirus for stable overexpression of FDXR 
                         Customized lentivirus expression plasmids for stable overexpression of FDXR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FDXR
    Search LifeMap BioReagents cell lines for FDXR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDXR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FDXR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mitochondrial Iron-Sulfur Cluster Biogenesis
    Electron Transport from NADPH to Ferredoxin0.33
    Mitochondrial Iron-Sulfur Cluster Biogenesis0.33
    2Metabolism
    Metabolism0.40
    3Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FDXR
        Direct p53 effectors


    3        Reactome Pathways for FDXR
        Mitochondrial Iron-Sulfur Cluster Biogenesis
    Metabolism
    Electron Transport from NADPH to Ferredoxin


    UniProtKB/Swiss-Prot: ADRO_HUMAN, P22570
    Pathway: Steroid metabolism; cholesterol metabolism


    FDXR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FDXR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for FDXR (P225701, 3 ENSP000002931954) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHITP497891, 3, ENSP000003420874EBI-1751533,EBI-741760 I2D: score=2 STRING: ENSP00000342087
    FDX1P101093, ENSP000002602704I2D: score=1 STRING: ENSP00000260270
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    CNOT1A5YKK63I2D: score=6 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2845396
    GO:0006694steroid biosynthetic process TAS1863359
    GO:0008203cholesterol metabolic process IEA--
    GO:0022900electron transport chain ----
    GO:0044281small molecule metabolic process TAS--

    FDXR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FDXR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for FDXR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TestosteroneEndogenous androgen receptor agonist[58-22-0]
    FlutamideNon-steroidal androgen receptor antagonist[13311-84-7]
    NilutamideAndrogen receptor antagonist. Orally active[63612-50-0]
    BicalutamideNon-steroidal androgen receptor antagonist[90357-06-5]
    Cl-4AS-1Steroidal androgen receptor agonist[188589-66-4]

    3 HMDB Compounds for FDXR    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 DrugBank Compounds for FDXR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--10592235

    10/26 Novoseek inferred chemical compound relationships for FDXR gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbazole 79.5 8 17554172 (2), 16511100 (1), 20516607 (1), 17161368 (1) (see all 5)
    putidaredoxin 72 3 9675270 (1), 17144670 (1)
    nadph 69.9 34 2403337 (2), 2294024 (2), 2078639 (1), 8251942 (1) (see all 23)
    iron-sulfur 64.2 4 8425475 (1), 8517924 (1), 1567230 (1), 7588394 (1)
    nadp+ 61.7 6 2236061 (1), 17635583 (1), 1315050 (1)
    steroid 58.6 14 11841224 (2), 10498693 (1), 11053423 (1), 1425418 (1) (see all 11)
    cholesterol 54 16 1425418 (2), 9029712 (1), 12787114 (1), 9818721 (1) (see all 13)
    flavin 53.7 2 8662973 (1)
    doca 53.1 1 10720486 (1)
    isoalloxazine 51.3 1 11053423 (1)

    Search CenterWatch for drugs/clinical trials and news about FDXR / ADRO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FDXR gene (7 alternative transcripts): 
    NM_001258012.1  NM_001258013.1  NM_001258014.1  NM_001258015.1  NM_001258016.1  NM_004110.3  NM_024417.2  

    Unigene Cluster for FDXR:

    Ferredoxin reductase
    Hs.69745  [show with all ESTs]
    Unigene Representative Sequence: BC034763
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000583881 ENST00000293195(uc002jlx.3 uc002jly.3 uc010wrm.2 uc002jlz.3 uc002jmb.3)
    ENST00000544854(uc010wri.2) ENST00000420580 ENST00000578473(uc010wrj.2 uc002jlw.3 uc010wrk.2)
    ENST00000581530 ENST00000579482 ENST00000577509 ENST00000583917 ENST00000442102(uc010wrl.2)
    ENST00000582944 ENST00000413947 ENST00000582710 ENST00000579893 ENST00000580492
    ENST00000581969 ENST00000579543 ENST00000581219
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDXR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FDXR
    SwitchGear 3'UTR luciferase reporter plasmidFDXR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FDXR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDXR
    Clone
    Products:
         
    OriGene clones in human, mouse for FDXR (see all 11)
    OriGene ORF clones in mouse, rat for FDXR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FDXR (NM_024417)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDXR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDXR
    Sirion Biotech Customized lentivirus for stable overexpression of FDXR 
                         Customized lentivirus expression plasmids for stable overexpression of FDXR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FDXR
    OriGene qSTAR qPCR primer pairs in human, mouse for FDXR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FDXR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDXR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDXR

    Additional mRNA sequence: 

    AK098648.1 AK223530.1 AK293208.1 AK293210.1 AK295307.1 AK298908.1 AK301779.1 AK301977.1 
    BC002960.1 BC011521.1 BC018911.2 BC034763.1 BC063493.1 BT006684.1 J03826.1 NR_047576.1 

    16 DOTS entries:

    DT.310507  DT.100817682  DT.100817683  DT.100027359  DT.40132463  DT.97844056  DT.120927223  DT.120927273 
    DT.100817679  DT.100817684  DT.120927270  DT.97844058  DT.120927215  DT.120927220  DT.120927271  DT.100817680 

    24/162 AceView cDNA sequences (see all 162):

    BQ707344 CB126298 CB852815 BX363976 BU184028 BX402070 BX375550 CR615445 
    CR590842 BU149238 BQ652928 AI754779 CR619324 BC063493 CR616367 BM547494 
    BQ425924 BC034763 CF129986 BM554402 BX341485 BM477975 CR594512 AU122525 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FDXR (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                      -                 -     -     -                                               -           -                           
    SP2:                                -     -                       -     -                                               -           -                           
    SP3:                          -     -     -                 -     -     -                                               -           -                           
    SP4:                          -     -     -                 -     -     -                                               -                                       
    SP5:                                -     -                 -     -     -                                               -           -                           

    ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for FDXR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FDXR expression in normal human tissues (normalized intensities)      FDXR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAAATAA
    FDXR Expression
    About this image


    FDXR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
             CERVIX   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   

    See FDXR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FDXR

    SOURCE GeneReport for Unigene cluster: Hs.69745
        SABiosciences Custom PCR Arrays for FDXR
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FDXR
    OriGene qSTAR qPCR primer pairs in human, mouse for FDXR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FDXR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDXR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDXR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDXR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FDXR gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fdxr1 , 5 ferredoxin reductase1, 5 85.74(n)1
    87.37(a)1
      11 (80.84 cM)5
    141491  NM_007997.11  NP_032023.11 
     1152680245 
    chicken
    (Gallus gallus)
    Aves FDXR1 ferredoxin reductase 68.92(n)
    69.28(a)
      769635  XM_001232922.2  XP_001232923.1 
    lizard
    (Anolis carolinensis)
    Reptilia FDXR6
    ferredoxin reductase
    65(a)
    1 ↔ 1
    2(115318527-115362750)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89592 Xenopus laevis transcribed sequence with moderate similarity more 73.2(n)    BU905014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005361151 NADPH:adrenodoxin oxidoreductase, mitochondrial-like 63.2(n)
    63.57(a)
      100536115  XM_003199654.1  XP_003199702.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dare1 , 3 molting cycle (sensu Insecta) electron
    transporter3
    defective in the avoidance of repellents1
    47(a)3
    56.23(n)1
    52.1(a)1
      2 47E43
    362031  NM_057802.51  NP_477150.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y62E10A.63   -- 36(a)   IV(13372168-13377437)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARH1(YDR376W)4
    ARH11
    Oxidoreductase of the mitochondrial inner membrane, more4
    Arh1p1
    42.79(n)1
    37.16(a)1
      4(1226822-1228303)4
    8519821, 4  NP_010664.31  NP_010664.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G323601 ferredoxin--NADP+ reductase 50.52(n)
    49.33(a)
      829370  NM_119388.4  NP_194962.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g02776001 hypothetical protein 52.27(n)
    50.91(a)
      4329009  NM_001053082.1  NP_001046547.1 


    ENSEMBL Gene Tree for FDXR (if available)
    TreeFam Gene Tree for FDXR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 SNPs in FDXR are shown (see all 445)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924223121,2
    --72858207(+) AGTGTA/GTCTGA 8 -- ds50010--------
    rs1157739501,2
    F--72858272(+) CTCGCC/GTGGGG 8 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1400078391,2
    C--72858300(+) GACAA-/GCTGCTTC
    TCAGTCCCCC
    GCTCC
    8 -- ds50010--------
    rs1161915571,2
    C,F--72858375(+) GGTCCC/TGGTCC 8 -- ds50011Minor allele frequency- T:0.02WA 118
    rs356887631,2
    C,F--72858391(-) GGGCTG/TCCCGG 8 -- ds50016Minor allele frequency- T:0.04NS WA 302
    rs1399918151,2
    --72858470(+) GCCAGA/GCCTGG 8 -- ds50010--------
    rs1848623391,2
    --72858537(+) CGCCAC/TCTGGT 8 -- ds50010--------
    rs340158231,2
    C,F,H--72858591(-) TTTTGG/AAAGGG 8 -- ds50018Minor allele frequency- A:0.00EA NS NA 350
    rs1929281861,2
    --72858620(+) TGGCTC/TTTGGT 8 -- ut31 nc-transcript-variant0--------
    rs346074061,2
    C,F--72858709(-) TGGGCC/TGATCT 8 -- ut31 nc-transcript-variant6Minor allele frequency- T:0.03NS WA 302

    HapMap Linkage Disequilibrium report for FDXR (72858619 - 72869156 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FDXR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518292CNV Loss19592680
    nsv833540CNV Loss17160897
    dgv3253n71CNV Loss21882294
    nsv908744CNV Loss21882294
    dgv3254n71CNV Loss21882294
    nsv908743CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FDXR
    DNA2.0 Custom Variant and Variant Library Synthesis for FDXR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103270    OMIM disorders: --

    15 diseases for FDXR:    About MalaCards
    congenital adrenal insufficiency    locked-in syndrome    congenital lipoid adrenal hyperplasia    lipoid adrenal hyperplasia
    androgen insensitivity syndrome    spinal-bulbar muscular atrophy    muscular atrophy    hypospadias
    toxoplasmosis    cytochrome p450    tuberculosis    prostate cancer
    prostatitis    colorectal cancer    colon cancer

    2 diseases from the University of Copenhagen DISEASES database for FDXR:
    locked-in syndrome     Congenital adrenal insufficiency

    FDXR for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for FDXR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 18.9 5 12614197 (2), 15863094 (1), 18767989 (1), 18293930 (1)
    colon cancer 0 3 11590433 (1), 14559799 (1)
    colorectal cancer 0 6 14559799 (3), 16528528 (2), 11590433 (1)
    tumors 0 16 16528528 (3), 19004824 (2), 14559799 (1), 14614330 (1)

    Genetic Association Database (GAD): FDXR
    Human Genome Epidemiology (HuGE) Navigator: FDXR (1 document)

    Export disorders for FDXR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FDXR gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with FDXR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence of the human adrenodoxin reductase gene. (PubMed id 2236061)1, 2, 9 Lin D.... Miller W.L. (1990)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen-->q25 are expressed in steroidogenic tissues. (PubMed id 2845396)1, 2 Solish S.B.... Miller W.L. (1988)
    6. Molecular cloning and sequence analysis of human placental ferredoxin. (PubMed id 2969697)1, 3 Mittal S.... Vickery L.E. (1988)
    7. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. (PubMed id 12370809)1, 9 Liu G. and Chen X. (2002)
    8. Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. (PubMed id 11053423)1, 9 Muller J.J....Heinemann U. (2001)
    9. Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. (PubMed id 19004824)1, 9 Pichiorri F....Huebner K. (2009)
    10. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. (PubMed id 1863359)1, 9 Sparkes R.S....Miller W.L. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2232 HGNC: 3642 AceView: FDXR Ensembl:ENSG00000161513 euGenes: HUgn2232
    ECgene: FDXR H-InvDB: FDXR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FDXR Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fdxr/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FDXR gene:
    Search GeneIP for patents involving FDXR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FDXR  
     OriGene qPCR primer pairs and template standards for FDXR   OriGene Protein Over-expression Lysate for FDXR  
     OriGene MassSpec something-or-other for FDXR   OriGene clones in human, mouse for FDXR  
     OriGene qSTAR qPCR primer pairs in human, mouse for FDXR   OriGene Purified Protein for FDXR  
     OriGene ORF clones in mouse, rat for FDXR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FDXR   OriGene Custom Protein Services for FDXR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FDXR
     QIAGEN SeqTarget long-range PCR primers for resequencing FDXR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDXR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDXR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDXR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDXR
     GenScript Custom Purified and Recombinant Proteins Services for FDXR GenScript cDNA clones with any tag delivered in your preferred vector for FDXR
     GenScript Custom Assay Services for FDXR GenScript Custom Superior Antibodies Services for FDXR
     GenScript Custom overexpressing Cell Line Services for FDXR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FDXR promoter
     Search Chromatin IP Primers for FDXR
     RT2 qPCR Primer Assay in human, mouse, rat FDXR
     GNC Network for FDXR
     SABiosciences Custom PCR Arrays for FDXR
     Tocris compounds for FDXR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for FDXR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FDXR antibodies
     FDXR proteins
     FDXR lysates
     Antibodies for FDXR
     See all of Abcam's Antibodies, Kits and Proteins for FDXR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FDXR
     Antibodies for FDXR
     ELISAs for FDXR
     CLIAs for FDXR
     Search LifeMap BioReagents cell lines for FDXR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDXR
     SwitchGear 3'UTR luciferase reporter plasmids for FDXR
     SwitchGear Promoter luciferase reporter plasmids for FDXR
     ThermoFisher Antibodies for FDXR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDXR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FDXR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FDXR
    Customized:
     lentivirus for stable overexpression of FDXR
     lentivirus expression plasmids for stable overexpression of FDXR
     adenovirus for overexpression of FDXR
     LSBio Antibodies in human, mouse, rat for FDXR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FDXR gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4