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Aliases for FDXACB1 Gene

Aliases for FDXACB1 Gene

  • Ferredoxin-Fold Anticodon Binding Domain Containing 1 2 3 5
  • FDX-ACDB Domain-Containing Protein 1 3 4
  • Hypothetical Protein BC006136 2 3
  • Ferredoxin-Fold Anticodon-Binding Domain-Containing Protein 1 3
  • HCG_2033039 3

External Ids for FDXACB1 Gene

Previous GeneCards Identifiers for FDXACB1 Gene

  • GC11M111252
  • GC11M111653
  • GC11M111745

Summaries for FDXACB1 Gene

Entrez Gene Summary for FDXACB1 Gene

  • This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDXACB1 Gene

FDXACB1 (Ferredoxin-Fold Anticodon Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is FARS2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXACB1 Gene

Genomics for FDXACB1 Gene

Regulatory Elements for FDXACB1 Gene

Enhancers for FDXACB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G111934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -58.8 -58822 11.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PPP2R1B SDHD C11orf52 HSPB2-C11orf52 HSPB2 TIMM8B FDXACB1 C11orf1 ALG9 C11orf57
GH11G111917 1.3 Ensembl ENCODE 11 -37.5 -37503 2.3 FOXA2 ATF1 MLX SIN3A ARID4B DMAP1 ZNF48 YY1 ETS1 TCF12 PPP2R1B FDXACB1 C11orf1 ALG9 C11orf52 SDHD CRYAB LOC105369494
GH11G111844 1.2 Ensembl ENCODE dbSUPER 10.7 +34.9 34878 3.1 PKNOX1 MAX FEZF1 ZNF316 ZNF600 FOS MAFK NFE2L2 ZNF10 CEBPB PPP2R1B ALG9 SIK2 C11orf1 FDXACB1 ENSG00000254980 GNG5P3 ALG9-IT1
GH11G112016 1.1 Ensembl ENCODE 10.2 -135.9 -135870 2.0 PKNOX1 FOXA2 ATF1 RAD21 RARA KAT2B GATA4 GATA2 CBX5 FOS C11orf57 PIH1D2 TIMM8B SDHD FDXACB1 C11orf1 ALG9 ENSG00000255334 GC11M112018
GH11G111573 1.1 Ensembl ENCODE dbSUPER 10 +307.1 307133 1.4 ZNF664 RNF2 ZSCAN4 ZNF398 YY1 NR2F2 SIK2 LAYN PPP2R1B ALG9 FDXACB1 C11orf1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FDXACB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FDXACB1 Gene

111,874,056 bp from pter
111,881,243 bp from pter
7,188 bases
Minus strand

Genomic View for FDXACB1 Gene

Genes around FDXACB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDXACB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDXACB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDXACB1 Gene

Proteins for FDXACB1 Gene

  • Protein details for FDXACB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferredoxin-fold anticodon-binding domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A0PJW7
    • B4DUU2

    Protein attributes for FDXACB1 Gene

    624 amino acids
    Molecular mass:
    70416 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH06136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FDXACB1 Gene


neXtProt entry for FDXACB1 Gene

Post-translational modifications for FDXACB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDXACB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDXACB1 Gene

Domains & Families for FDXACB1 Gene

Protein Domains for FDXACB1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FDXACB1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FDXACB1 Gene

Function for FDXACB1 Gene

Gene Ontology (GO) - Molecular Function for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004826 phenylalanine-tRNA ligase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FDXACB1: view

Phenotypes for FDXACB1 Gene

genes like me logo Genes that share phenotypes with FDXACB1: view

Animal Models for FDXACB1 Gene

MGI Knock Outs for FDXACB1:

Animal Model Products

CRISPR Products

miRNA for FDXACB1 Gene

miRTarBase miRNAs that target FDXACB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDXACB1 Gene

Localization for FDXACB1 Gene

Gene Ontology (GO) - Cellular Components for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009328 phenylalanine-tRNA ligase complex IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FDXACB1 Gene

Pathways & Interactions for FDXACB1 Gene

SuperPathways for FDXACB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006432 phenylalanyl-tRNA aminoacylation IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Pathways by source and SIGNOR curated interactions for FDXACB1 Gene

Transcripts for FDXACB1 Gene

mRNA/cDNA for FDXACB1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDXACB1 Gene

Ferredoxin-fold anticodon binding domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FDXACB1 Gene

No ASD Table

Relevant External Links for FDXACB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FDXACB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FDXACB1 Gene

Protein differential expression in normal tissues from HIPED for FDXACB1 Gene

This gene is overexpressed in Plasma (30.9), Adipocyte (19.3), and Lung (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FDXACB1 Gene

Protein tissue co-expression partners for FDXACB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FDXACB1 Gene:


SOURCE GeneReport for Unigene cluster for FDXACB1 Gene:

genes like me logo Genes that share expression patterns with FDXACB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FDXACB1 Gene

Orthologs for FDXACB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDXACB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FDXACB1 34
  • 99.52 (n)
-- 35
  • 99 (a)
(Canis familiaris)
Mammalia FDXACB1 34
  • 87.11 (n)
(Bos Taurus)
Mammalia FDXACB1 34
  • 85.58 (n)
-- 35
  • 81 (a)
(Mus musculus)
Mammalia Fdxacb1 34 16 35
  • 80.55 (n)
(Rattus norvegicus)
Mammalia Fdxacb1 34
  • 79.67 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
-- 35
  • 53 (a)
-- 35
  • 16 (a)
(Gallus gallus)
Aves FDXACB1 34
  • 58.14 (n)
-- 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fdxacb1 34
  • 51.83 (n)
(Danio rerio)
Actinopterygii LOC566022 34
  • 51.68 (n)
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSF1 35
  • 18 (a)
Species where no ortholog for FDXACB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDXACB1 Gene

Gene Tree for FDXACB1 (if available)
Gene Tree for FDXACB1 (if available)

Paralogs for FDXACB1 Gene

Paralogs for FDXACB1 Gene

(1) SIMAP similar genes for FDXACB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FDXACB1: view

Variants for FDXACB1 Gene

Sequence variations from dbSNP and Humsavar for FDXACB1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000043705 -- 111,875,242(+) AGGGA(A/C)AAAAT nc-transcript-variant, reference, missense
rs1000266546 -- 111,879,973(+) TAGTT(G/T)AGTTT intron-variant, upstream-variant-2KB
rs1001322959 -- 111,879,458(+) GTTCT(C/G)GGTGA upstream-variant-2KB, utr-variant-5-prime
rs1003034139 -- 111,878,610(+) TGCGT(C/G)CACAA intron-variant, upstream-variant-2KB, reference, missense
rs1003391583 -- 111,878,245(+) GGGCT(C/G)GGATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FDXACB1 Gene

Variant ID Type Subtype PubMed ID
esv3627745 CNV gain 21293372
nsv832269 CNV loss 17160897

Variation tolerance for FDXACB1 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDXACB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXACB1 Gene

Disorders for FDXACB1 Gene

Relevant External Links for FDXACB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FDXACB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDXACB1 Gene

Publications for FDXACB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FDXACB1 Gene

Sources for FDXACB1 Gene

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