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Aliases for FDXACB1 Gene

Aliases for FDXACB1 Gene

  • Ferredoxin-Fold Anticodon Binding Domain Containing 1 2 3 5
  • FDX-ACDB Domain-Containing Protein 1 3 4
  • Hypothetical Protein BC006136 2 3
  • Ferredoxin-Fold Anticodon-Binding Domain-Containing Protein 1 3
  • HCG_2033039 3

External Ids for FDXACB1 Gene

Previous GeneCards Identifiers for FDXACB1 Gene

  • GC11M111252
  • GC11M111653
  • GC11M111745

Summaries for FDXACB1 Gene

Entrez Gene Summary for FDXACB1 Gene

  • This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDXACB1 Gene

FDXACB1 (Ferredoxin-Fold Anticodon Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is FARS2.

Additional gene information for FDXACB1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXACB1 Gene

Genomics for FDXACB1 Gene

Regulatory Elements for FDXACB1 Gene

Enhancers for FDXACB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H111934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -58.8 -58822 11 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 TIMM8B FDXACB1 C11orf1 ALG9 NKAPD1
GH11H112023 1.1 ENCODE 12.7 -143.9 -143884 2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 PPP2R1B FDXACB1 ALG9 NKAPD1 PIH1D2 DIXDC1 IL18 CRYAB C11orf52 DLAT
GH11H111917 1.2 Ensembl ENCODE 11 -37.5 -37503 2 ELF3 TBP ARID4B SIN3A DMAP1 BMI1 RAD21 YY1 ETS1 SCRT2 PPP2R1B FDXACB1 C11orf1 ALG9 C11orf52 SDHD LOC105369494 CRYAB
GH11H111844 1.1 Ensembl ENCODE dbSUPER 10.7 +34.9 34878 3 PKNOX1 CEBPB MAX FEZF1 JUND POLR2A FOS MAFK MYC SP7 PPP2R1B ALG9 SIK2 FDXACB1 C11orf1 ENSG00000254980 ALG9-IT1 GNG5P3
GH11H112016 1.1 Ensembl ENCODE 10.2 -135.9 -135870 1 PKNOX1 FOXA2 ATF1 BATF RAD21 RARA FOS RUNX3 CREM IKZF2 PIH1D2 NKAPD1 TIMM8B SDHD FDXACB1 C11orf1 ALG9 ENSG00000255334 GC11M112018
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FDXACB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FDXACB1 Gene

Chromosome:
11
Start:
111,874,056 bp from pter
End:
111,881,243 bp from pter
Size:
7,188 bases
Orientation:
Minus strand

Genomic View for FDXACB1 Gene

Genes around FDXACB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDXACB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDXACB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDXACB1 Gene

Proteins for FDXACB1 Gene

  • Protein details for FDXACB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP7-FDXA1_HUMAN
    Recommended name:
    Ferredoxin-fold anticodon-binding domain-containing protein 1
    Protein Accession:
    Q9BRP7
    Secondary Accessions:
    • A0PJW7
    • B4DUU2

    Protein attributes for FDXACB1 Gene

    Size:
    624 amino acids
    Molecular mass:
    70416 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FDXACB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FDXACB1 Gene

Post-translational modifications for FDXACB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDXACB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDXACB1 Gene

Domains & Families for FDXACB1 Gene

Gene Families for FDXACB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FDXACB1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FDXACB1: view

No data available for UniProtKB/Swiss-Prot for FDXACB1 Gene

Function for FDXACB1 Gene

Gene Ontology (GO) - Molecular Function for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004826 phenylalanine-tRNA ligase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FDXACB1: view
genes like me logo Genes that share phenotypes with FDXACB1: view

Animal Models for FDXACB1 Gene

MGI Knock Outs for FDXACB1:

Animal Model Products

CRISPR Products

miRNA for FDXACB1 Gene

miRTarBase miRNAs that target FDXACB1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FDXACB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDXACB1 Gene

Localization for FDXACB1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009328 phenylalanine-tRNA ligase complex IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FDXACB1 Gene

Pathways & Interactions for FDXACB1 Gene

SuperPathways for FDXACB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006432 phenylalanyl-tRNA aminoacylation IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Pathways by source and SIGNOR curated interactions for FDXACB1 Gene

Drugs & Compounds for FDXACB1 Gene

No Compound Related Data Available

Transcripts for FDXACB1 Gene

mRNA/cDNA for FDXACB1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDXACB1 Gene

Ferredoxin-fold anticodon binding domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FDXACB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FDXACB1 Gene

No ASD Table

Relevant External Links for FDXACB1 Gene

GeneLoc Exon Structure for
FDXACB1
ECgene alternative splicing isoforms for
FDXACB1

Expression for FDXACB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FDXACB1 Gene

Protein differential expression in normal tissues from HIPED for FDXACB1 Gene

This gene is overexpressed in Plasma (30.9), Adipocyte (19.3), and Lung (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FDXACB1 Gene



Protein tissue co-expression partners for FDXACB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FDXACB1 Gene:

FDXACB1

SOURCE GeneReport for Unigene cluster for FDXACB1 Gene:

Hs.697132
genes like me logo Genes that share expression patterns with FDXACB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FDXACB1 Gene

Orthologs for FDXACB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDXACB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDXACB1 33
  • 99.52 (n)
-- 34
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FDXACB1 33
  • 87.11 (n)
cow
(Bos Taurus)
Mammalia FDXACB1 33
  • 85.58 (n)
-- 34
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fdxacb1 33 16 34
  • 80.55 (n)
rat
(Rattus norvegicus)
Mammalia Fdxacb1 33
  • 79.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FDXACB1 33
  • 58.14 (n)
-- 34
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fdxacb1 33
  • 51.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC566022 33
  • 51.68 (n)
FDXACB1 34
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSF1 34
  • 18 (a)
OneToMany
Species where no ortholog for FDXACB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDXACB1 Gene

ENSEMBL:
Gene Tree for FDXACB1 (if available)
TreeFam:
Gene Tree for FDXACB1 (if available)

Paralogs for FDXACB1 Gene

Paralogs for FDXACB1 Gene

(1) SIMAP similar genes for FDXACB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FDXACB1: view

Variants for FDXACB1 Gene

Sequence variations from dbSNP and Humsavar for FDXACB1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000043705 -- 111,875,242(+) AGGGA(A/C)AAAAT nc-transcript-variant, reference, missense
rs1000266546 -- 111,879,973(+) TAGTT(G/T)AGTTT intron-variant, upstream-variant-2KB
rs1001322959 -- 111,879,458(+) GTTCT(C/G)GGTGA upstream-variant-2KB, utr-variant-5-prime
rs1003034139 -- 111,878,610(+) TGCGT(C/G)CACAA intron-variant, upstream-variant-2KB, reference, missense
rs1003391583 -- 111,878,245(+) GGGCT(C/G)GGATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FDXACB1 Gene

Variant ID Type Subtype PubMed ID
esv3627745 CNV gain 21293372
nsv832269 CNV loss 17160897

Variation tolerance for FDXACB1 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDXACB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FDXACB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXACB1 Gene

Disorders for FDXACB1 Gene

Relevant External Links for FDXACB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FDXACB1

No disorders were found for FDXACB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDXACB1 Gene

Publications for FDXACB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 60

Products for FDXACB1 Gene

Sources for FDXACB1 Gene

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