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Aliases for FDXACB1 Gene

Aliases for FDXACB1 Gene

  • Ferredoxin-Fold Anticodon Binding Domain Containing 1 2 3
  • FDX-ACDB Domain-Containing Protein 1 3 4
  • Hypothetical Protein BC006136 2 3
  • Ferredoxin-Fold Anticodon-Binding Domain-Containing Protein 1 3
  • HCG_2033039 3

External Ids for FDXACB1 Gene

Previous GeneCards Identifiers for FDXACB1 Gene

  • GC11M111252
  • GC11M111653
  • GC11M111745

Summaries for FDXACB1 Gene

Entrez Gene Summary for FDXACB1 Gene

  • This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDXACB1 Gene

FDXACB1 (Ferredoxin-Fold Anticodon Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is FARS2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXACB1 Gene

Genomics for FDXACB1 Gene

Regulatory Elements for FDXACB1 Gene

Genomic Location for FDXACB1 Gene

111,874,056 bp from pter
111,881,255 bp from pter
7,200 bases
Minus strand

Genomic View for FDXACB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FDXACB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDXACB1 Gene

Proteins for FDXACB1 Gene

  • Protein details for FDXACB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferredoxin-fold anticodon-binding domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A0PJW7
    • B4DUU2

    Protein attributes for FDXACB1 Gene

    624 amino acids
    Molecular mass:
    70416 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH06136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FDXACB1 Gene


neXtProt entry for FDXACB1 Gene

Proteomics data for FDXACB1 Gene at MOPED

Post-translational modifications for FDXACB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDXACB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDXACB1 Gene

Domains for FDXACB1 Gene

Protein Domains for FDXACB1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FDX-ACB domain.
  • Contains 1 FDX-ACB domain.
genes like me logo Genes that share domains with FDXACB1: view

No data available for Gene Families for FDXACB1 Gene

Function for FDXACB1 Gene

Gene Ontology (GO) - Molecular Function for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0004826 phenylalanine-tRNA ligase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FDXACB1: view

Animal Model Products

CRISPR Products

miRNA for FDXACB1 Gene

miRTarBase miRNAs that target FDXACB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FDXACB1 Gene

Localization for FDXACB1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FDXACB1 Gene

Pathways for FDXACB1 Gene

SuperPathways for FDXACB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006432 phenylalanyl-tRNA aminoacylation IEA --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Pathways by source for FDXACB1 Gene

Transcripts for FDXACB1 Gene

mRNA/cDNA for FDXACB1 Gene

(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDXACB1 Gene

Ferredoxin-fold anticodon binding domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDXACB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDXACB1 Gene

No ASD Table

Relevant External Links for FDXACB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FDXACB1 Gene

mRNA expression in normal human tissues for FDXACB1 Gene

Protein differential expression in normal tissues for FDXACB1 Gene

This gene is overexpressed in Plasma (30.9), Adipocyte (19.3), and Lung (17.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FDXACB1 Gene

SOURCE GeneReport for Unigene cluster for FDXACB1 Gene Hs.697132

genes like me logo Genes that share expressions with FDXACB1: view

Expression partners for FDXACB1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FDXACB1 Gene

Orthologs for FDXACB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDXACB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FDXACB1 35
  • 85.58 (n)
  • 81.09 (a)
-- 36
  • 81 (a)
(Canis familiaris)
Mammalia FDXACB1 35
  • 87.11 (n)
  • 83.47 (a)
(Mus musculus)
Mammalia Fdxacb1 35
  • 80.55 (n)
  • 71.86 (a)
Fdxacb1 16
Fdxacb1 36
  • 72 (a)
(Pan troglodytes)
Mammalia FDXACB1 35
  • 99.52 (n)
  • 99.04 (a)
-- 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fdxacb1 35
  • 79.67 (n)
  • 71.53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
-- 36
  • 16 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves FDXACB1 35
  • 58.14 (n)
  • 51.16 (a)
-- 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fdxacb1 35
  • 51.83 (n)
  • 43.49 (a)
(Danio rerio)
Actinopterygii LOC566022 35
  • 51.68 (n)
  • 46.03 (a)
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSF1 36
  • 18 (a)
Species with no ortholog for FDXACB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDXACB1 Gene

Gene Tree for FDXACB1 (if available)
Gene Tree for FDXACB1 (if available)

Paralogs for FDXACB1 Gene

Paralogs for FDXACB1 Gene

(1) SIMAP similar genes for FDXACB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FDXACB1: view

Variants for FDXACB1 Gene

Sequence variations from dbSNP and Humsavar for FDXACB1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs605655 -- 111,874,735(+) ccgcc(G/T)gggcg utr-variant-3-prime, nc-transcript-variant
rs634983 -- 111,876,703(+) GAGAC(C/T)GAATC intron-variant
rs3168263 - 111,875,374(-) CTGCC(A/C)CTAGT reference, missense, nc-transcript-variant
rs7124696 -- 111,876,573(+) CCTTC(A/G)AAAGG synonymous-codon, reference, nc-transcript-variant
rs10670929 -- 111,874,595(+) ATACA(-/A/AA)AAAAA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FDXACB1 Gene

Variant ID Type Subtype PubMed ID
nsv832269 CNV Loss 17160897

Relevant External Links for FDXACB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXACB1 Gene

Disorders for FDXACB1 Gene

No disorders were found for FDXACB1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FDXACB1 Gene

Publications for FDXACB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FDXACB1 Gene

Sources for FDXACB1 Gene

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