Aliases for FDXACB1 Gene
Aliases for FDXACB1 Gene
External Ids for FDXACB1 Gene
- HGNC: 25110
- Entrez Gene: 91893
- Ensembl: ENSG00000255561
- UniProtKB: Q9BRP7
Previous GeneCards Identifiers for FDXACB1 Gene
- GC11M111252
- GC11M111653
- GC11M111745
Summaries for FDXACB1 Gene
-
This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for FDXACB1 Gene
FDXACB1 (Ferredoxin-Fold Anticodon Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is FARS2.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXACB1 Gene
Genomics for FDXACB1 Gene
Regulatory Elements for FDXACB1 Gene
Enhancers for FDXACB1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FDXACB1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FDXACB1 Gene
- Chromosome:
- 11
- Start:
- 111,874,056 bp from pter
- End:
- 111,881,243 bp from pter
- Size:
- 7,188 bases
- Orientation:
- Minus strand
Genomic View for FDXACB1 Gene
Genes around FDXACB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.1 by Ensembl
- 11q23.1 by Entrez Gene
- 11q23.1 by HGNC
FDXACB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FDXACB1 Gene
Proteins for FDXACB1 Gene
-
Protein details for FDXACB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BRP7-FDXA1_HUMAN
- Recommended name:
- Ferredoxin-fold anticodon-binding domain-containing protein 1
- Protein Accession:
- Q9BRP7
- A0PJW7
- B4DUU2
Protein attributes for FDXACB1 Gene
- Size:
- 624 amino acids
- Molecular mass:
- 70416 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH06136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FDXACB1 Gene
Post-translational modifications for FDXACB1 Gene
Other Protein References for FDXACB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FDXACB1
- Invitrogen Antibodies for FDXACB1
- Search GeneTex for Antibodies for FDXACB1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FDXACB1
- Origene Custom Protein Services for FDXACB1
- Novus Biologicals proteins for FDXACB1
- Search GeneTex for Proteins for FDXACB1
Assay Products
- antibodies-online Kits for FDXACB1: See all 2
No data available for DME Specific Peptides for FDXACB1 Gene
Domains & Families for FDXACB1 Gene
Protein Domains for FDXACB1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FDXACB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for FDXACB1 Gene
Function for FDXACB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004826 | phenylalanine-tRNA ligase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for FDXACB1 Gene
- MGI mutant phenotypes for FDXACB1:
- inferred from 1 alleles
Animal Models for FDXACB1 Gene
- MGI Knock Outs for FDXACB1:
-
- Fdxacb1 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FDXACB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FDXACB1 gene
- Search ViGene Biosciences for FDXACB1
CRISPR Products
-
OriGene CRISPR knockouts for FDXACB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FDXACB1
- GenScript: Design CRISPR guide RNA sequences for FDXACB1
miRNA for FDXACB1 Gene
- miRTarBase miRNAs that target FDXACB1
miRNA Products
- Search ViGene Biosciences for FDXACB1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FDXACB1
- Browse OriGene Inhibitory RNA Products For FDXACB1
-
ViGene Biosciences ready-to-package AAV shRNAs for FDXACB1 gene
Clone Products
-
OriGene ORF clones in human for FDXACB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FDXACB1
-
ViGene Biosciences adenoviral particle packaged cDNA for FDXACB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FDXACB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FDXACB1 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDXACB1 Gene
Localization for FDXACB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009328 | phenylalanine-tRNA ligase complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FDXACB1 Gene
Pathways & Interactions for FDXACB1 Gene
No Data Available
Interacting Proteins for FDXACB1 Gene
Selected Interacting proteins:
ENSP00000260257
Q9BRP7-FDXA1_HUMAN
for FDXACB1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006432 | phenylalanyl-tRNA aminoacylation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FDXACB1 Gene
Transcripts for FDXACB1 Gene
mRNA/cDNA for FDXACB1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FDXACB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FDXACB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FDXACB1
- GenScript: Design CRISPR guide RNA sequences for FDXACB1
miRNA Products
- Search ViGene Biosciences for FDXACB1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FDXACB1
- Browse OriGene Inhibitory RNA Products For FDXACB1
-
ViGene Biosciences ready-to-package AAV shRNAs for FDXACB1 gene
Clone Products
-
OriGene ORF clones in human for FDXACB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FDXACB1 Gene
This gene is overexpressed in Plasma (30.9), Adipocyte (19.3), and Lung (17.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FDXACB1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FDXACB1 Gene:
FDXACB1SOURCE GeneReport for Unigene cluster for FDXACB1 Gene:
Hs.697132Primer Products
-
OriGene qPCR primer pairs for FDXACB1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FDXACB1 Gene
Orthologs for FDXACB1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FDXACB1 34 |
|
||
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | FDXACB1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FDXACB1 34 |
|
||
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Fdxacb1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fdxacb1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | FDXACB1 34 |
|
||
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fdxacb1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC566022 34 |
|
||
| FDXACB1 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSF1 35 |
|
OneToMany |
- Species where no ortholog for FDXACB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FDXACB1 Gene
(1) SIMAP similar genes for FDXACB1 Gene using alignment to 4 proteins:
Variants for FDXACB1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000043705 | -- | 111,875,242(+) | AGGGA(A/C)AAAAT | nc-transcript-variant, reference, missense | |
| rs1000266546 | -- | 111,879,973(+) | TAGTT(G/T)AGTTT | intron-variant, upstream-variant-2KB | |
| rs1001322959 | -- | 111,879,458(+) | GTTCT(C/G)GGTGA | upstream-variant-2KB, utr-variant-5-prime | |
| rs1003034139 | -- | 111,878,610(+) | TGCGT(C/G)CACAA | intron-variant, upstream-variant-2KB, reference, missense | |
| rs1003391583 | -- | 111,878,245(+) | GGGCT(C/G)GGATT | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3627745 | CNV | gain | 21293372 |
| nsv832269 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.22;
52.31% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FDXACB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FDXACB1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXACB1 Gene
Disorders for FDXACB1 Gene
Relevant External Links for FDXACB1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FDXACB1
No disorders were found for FDXACB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDXACB1 Gene
Publications for FDXACB1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
Products for FDXACB1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FDXACB1
- Origene Custom Protein Services for FDXACB1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FDXACB1
- Browse OriGene Inhibitory RNA Products For FDXACB1
- OriGene qPCR primer pairs for FDXACB1
- OriGene CRISPR knockouts for FDXACB1
- OriGene ORF clones in human for FDXACB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FDXACB1
- GenScript: Next-day shipping cDNA ORF clone for FDXACB1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FDXACB1
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- GenScript Custom overexpressing Cell Line Services for FDXACB1
- GenScript: Design CRISPR guide RNA sequences for FDXACB1
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for FDXACB1
- Novus Biologicals proteins for FDXACB1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FDXACB1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FDXACB1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FDXACB1 gene
- Search ViGene Biosciences for FDXACB1
- Horizon Cell Lines for FDXACB1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FDXACB1
- VectorBuilder custom plasmid, inducible vectors for FDXACB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FDXACB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FDXACB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer