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Aliases for FDXACB1 Gene

Aliases for FDXACB1 Gene

  • Ferredoxin-Fold Anticodon Binding Domain Containing 1 2 3 5
  • FDX-ACDB Domain-Containing Protein 1 3 4
  • Hypothetical Protein BC006136 2 3
  • Ferredoxin-Fold Anticodon-Binding Domain-Containing Protein 1 3
  • HCG_2033039 3

External Ids for FDXACB1 Gene

Previous GeneCards Identifiers for FDXACB1 Gene

  • GC11M111252
  • GC11M111653
  • GC11M111745

Summaries for FDXACB1 Gene

Entrez Gene Summary for FDXACB1 Gene

  • This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDXACB1 Gene

FDXACB1 (Ferredoxin-Fold Anticodon Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is FARS2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXACB1 Gene

Genomics for FDXACB1 Gene

Regulatory Elements for FDXACB1 Gene

Enhancers for FDXACB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111917 0.5 ENCODE 11 -37.5 -37503 2.3 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZHX2 MIER2 PPARG PPP2R1B FDXACB1 C11orf1 ALG9 C11orf52 SDHD CRYAB LOC105369494
GH11F111844 1.2 Ensembl ENCODE 10.7 +34.9 34878 3.1 PKNOX1 CEBPB MAX FEZF1 ZNF316 JUND ZFP3 FOS ZNF600 MYC PPP2R1B ALG9 SIK2 C11orf1 FDXACB1 ENSG00000254980 GNG5P3 ALG9-IT1
GH11F111931 0.9 Ensembl ENCODE 10.6 -51.0 -50958 0.8 CTCF ARID4B ZNF384 RAD21 GATA3 SMC3 MIXL1 GATAD2A ZNF654 TFE3 C11orf1 FDXACB1 ALG9 C11orf57 PIH1D2 ENSG00000255292 SDHD TIMM8B RNA5SP351 ENSG00000255286
GH11F111933 0.2 Ensembl 10.6 -52.3 -52258 0.2 C11orf1 FDXACB1 ALG9 C11orf57 PIH1D2 ENSG00000255292 SDHD TIMM8B RNA5SP351 ENSG00000255286
GH11F111934 1.2 FANTOM5 Ensembl ENCODE 10.6 -58.8 -58822 11.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 ENSG00000255292 TIMM8B FDXACB1 C11orf1 ALG9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FDXACB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FDXACB1 Gene

Chromosome:
11
Start:
111,874,056 bp from pter
End:
111,881,243 bp from pter
Size:
7,188 bases
Orientation:
Minus strand

Genomic View for FDXACB1 Gene

Genes around FDXACB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDXACB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDXACB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDXACB1 Gene

Proteins for FDXACB1 Gene

  • Protein details for FDXACB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP7-FDXA1_HUMAN
    Recommended name:
    Ferredoxin-fold anticodon-binding domain-containing protein 1
    Protein Accession:
    Q9BRP7
    Secondary Accessions:
    • A0PJW7
    • B4DUU2

    Protein attributes for FDXACB1 Gene

    Size:
    624 amino acids
    Molecular mass:
    70416 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FDXACB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FDXACB1 Gene

Post-translational modifications for FDXACB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDXACB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDXACB1 Gene

Domains & Families for FDXACB1 Gene

Protein Domains for FDXACB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRP7

UniProtKB/Swiss-Prot:

FDXA1_HUMAN :
  • Contains 1 FDX-ACB domain.
Domain:
  • Contains 1 FDX-ACB domain.
genes like me logo Genes that share domains with FDXACB1: view

No data available for Gene Families for FDXACB1 Gene

Function for FDXACB1 Gene

Gene Ontology (GO) - Molecular Function for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0004826 NOT phenylalanine-tRNA ligase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FDXACB1: view

Phenotypes for FDXACB1 Gene

genes like me logo Genes that share phenotypes with FDXACB1: view

Animal Models for FDXACB1 Gene

MGI Knock Outs for FDXACB1:

Animal Model Products

miRNA for FDXACB1 Gene

miRTarBase miRNAs that target FDXACB1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDXACB1 Gene

Localization for FDXACB1 Gene

Gene Ontology (GO) - Cellular Components for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FDXACB1 Gene

Pathways & Interactions for FDXACB1 Gene

SuperPathways for FDXACB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006432 NOT phenylalanyl-tRNA aminoacylation IBA --
GO:0008033 tRNA processing IEA --
GO:0070475 rRNA base methylation IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Pathways by source and SIGNOR curated interactions for FDXACB1 Gene

Transcripts for FDXACB1 Gene

mRNA/cDNA for FDXACB1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDXACB1 Gene

Ferredoxin-fold anticodon binding domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDXACB1 Gene

No ASD Table

Relevant External Links for FDXACB1 Gene

GeneLoc Exon Structure for
FDXACB1
ECgene alternative splicing isoforms for
FDXACB1

Expression for FDXACB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FDXACB1 Gene

Protein differential expression in normal tissues from HIPED for FDXACB1 Gene

This gene is overexpressed in Plasma (30.9), Adipocyte (19.3), and Lung (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FDXACB1 Gene



Protein tissue co-expression partners for FDXACB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FDXACB1 Gene:

FDXACB1

SOURCE GeneReport for Unigene cluster for FDXACB1 Gene:

Hs.697132
genes like me logo Genes that share expression patterns with FDXACB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FDXACB1 Gene

Orthologs for FDXACB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDXACB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDXACB1 34
  • 99.52 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FDXACB1 34
  • 87.11 (n)
cow
(Bos Taurus)
Mammalia FDXACB1 34
  • 85.58 (n)
-- 35
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fdxacb1 34 16 35
  • 80.55 (n)
rat
(Rattus norvegicus)
Mammalia Fdxacb1 34
  • 79.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FDXACB1 34
  • 58.14 (n)
-- 35
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fdxacb1 34
  • 51.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC566022 34
  • 51.68 (n)
FDXACB1 35
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSF1 35
  • 18 (a)
OneToMany
Species where no ortholog for FDXACB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDXACB1 Gene

ENSEMBL:
Gene Tree for FDXACB1 (if available)
TreeFam:
Gene Tree for FDXACB1 (if available)

Paralogs for FDXACB1 Gene

Paralogs for FDXACB1 Gene

(1) SIMAP similar genes for FDXACB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FDXACB1: view

Variants for FDXACB1 Gene

Sequence variations from dbSNP and Humsavar for FDXACB1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10670929 -- 111,874,604(+) ATACA(-/A/AA)AAAAA nc-transcript-variant, utr-variant-3-prime
rs10789850 -- 111,880,105(+) AGGTA(C/T)AGGTT intron-variant, upstream-variant-2KB
rs10789851 -- 111,880,231(+) AGTGT(C/G)TGTTG intron-variant, upstream-variant-2KB
rs111335057 -- 111,877,706(+) GAGGC(A/G)GGGTT intron-variant, upstream-variant-2KB
rs111526632 -- 111,874,206(+) CTCTC(A/G)TAAGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FDXACB1 Gene

Variant ID Type Subtype PubMed ID
esv3627745 CNV gain 21293372
nsv832269 CNV loss 17160897

Variation tolerance for FDXACB1 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDXACB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FDXACB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXACB1 Gene

Disorders for FDXACB1 Gene

Relevant External Links for FDXACB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FDXACB1

No disorders were found for FDXACB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDXACB1 Gene

Publications for FDXACB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FDXACB1 Gene

Sources for FDXACB1 Gene

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