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Aliases for FDX2 Gene

Aliases for FDX2 Gene

  • Ferredoxin 2 2 5
  • Adrenodoxin-Like Protein 3 4
  • FDX1L 3 4
  • Adrenodoxin-Like Protein, Mitochondrial 3
  • Ferredoxin-2, Mitochondrial 3
  • Ferredoxin-1-Like Protein 4
  • Ferredoxin 1-Like 2
  • Ferredoxin 1 Like 3

External Ids for FDX2 Gene

Previous HGNC Symbols for FDX2 Gene

  • FDX1L

Previous GeneCards Identifiers for FDX2 Gene

  • GC00U990097

Summaries for FDX2 Gene

Entrez Gene Summary for FDX2 Gene

  • This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]

GeneCards Summary for FDX2 Gene

FDX2 (Ferredoxin 2) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial iron-sulfur cluster biogenesis. An important paralog of this gene is ENSG00000167807.

UniProtKB/Swiss-Prot for FDX2 Gene

  • Essential for heme A and Fe/S protein biosynthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDX2 Gene

Genomics for FDX2 Gene

Regulatory Elements for FDX2 Gene

Enhancers for FDX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010331 1.2 ENCODE 6.9 -17.7 -17662 3.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KANK2 LOC100418883 DOCK6 S1PR2 LOC105372273 RAVER1 ZNF561 FBXL12 ZNF177 ICAM3
GH19F010314 1.1 ENCODE 7.2 +0.3 262 1.9 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 PAF1 LOC100128428 ICAM3 FDX2 KRI1 ENSG00000167807 ZGLP1
GH19F010100 1.5 FANTOM5 ENCODE 4.4 +211.6 211628 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F010407 1.2 FANTOM5 ENCODE 4.8 -92.8 -92821 2.1 KLF1 TBL1XR1 MAX BCL11B ZNF48 ZNF121 ZFHX2 GLIS2 ZNF366 POLR2A TYK2 FDX2 PDE4A C19orf38 ICAM3 S1PR5 ATG4D P2RY11 GC19P010412 GC19P010382
GH19F010321 0.8 ENCODE 6.8 -6.2 -6181 1.8 HDGF ATF1 THRB GLIS2 CREM SMAD5 ZBTB2 ZBTB11 ZFP69B SMARCA4 RAVER1 ICAM3 FDX2 ENSG00000267303 GC19M010320
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FDX2 on UCSC Golden Path with GeneCards custom track

Promoters for FDX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214845 515 1401 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 PAF1

Genomic Location for FDX2 Gene

Chromosome:
19
Start:
10,310,045 bp from pter
End:
10,316,015 bp from pter
Size:
5,971 bases
Orientation:
Minus strand

Genomic View for FDX2 Gene

Genes around FDX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDX2 Gene

Proteins for FDX2 Gene

  • Protein details for FDX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4F2-FDX2_HUMAN
    Recommended name:
    Ferredoxin-2, mitochondrial
    Protein Accession:
    Q6P4F2
    Secondary Accessions:
    • Q8N8B8

    Protein attributes for FDX2 Gene

    Size:
    183 amino acids
    Molecular mass:
    19521 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FDX2 Gene

    Alternative splice isoforms for FDX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FDX2 Gene

Post-translational modifications for FDX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDX2 Gene

Domains & Families for FDX2 Gene

Suggested Antigen Peptide Sequences for FDX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P4F2

UniProtKB/Swiss-Prot:

FDX2_HUMAN :
  • Contains 1 2Fe-2S ferredoxin-type domain.
  • Belongs to the adrenodoxin/putidaredoxin family.
Domain:
  • Contains 1 2Fe-2S ferredoxin-type domain.
Family:
  • Belongs to the adrenodoxin/putidaredoxin family.
genes like me logo Genes that share domains with FDX2: view

No data available for Gene Families for FDX2 Gene

Function for FDX2 Gene

Molecular function for FDX2 Gene

UniProtKB/Swiss-Prot Function:
Essential for heme A and Fe/S protein biosynthesis.

Gene Ontology (GO) - Molecular Function for FDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0009055 electron carrier activity IEA,TAS --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with FDX2: view

Phenotypes for FDX2 Gene

GenomeRNAi human phenotypes for FDX2:
genes like me logo Genes that share phenotypes with FDX2: view

Animal Model Products

miRNA for FDX2 Gene

miRTarBase miRNAs that target FDX2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FDX2 Gene

Localization for FDX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDX2 Gene

Mitochondrion. Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FDX2 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for FDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FDX2: view

Pathways & Interactions for FDX2 Gene

genes like me logo Genes that share pathways with FDX2: view

Gene Ontology (GO) - Biological Process for FDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0016125 sterol metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FDX2: view

No data available for SIGNOR curated interactions for FDX2 Gene

Transcripts for FDX2 Gene

Unigene Clusters for FDX2 Gene

Ferredoxin 1-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDX2 Gene

No ASD Table

Relevant External Links for FDX2 Gene

GeneLoc Exon Structure for
FDX2
ECgene alternative splicing isoforms for
FDX2

Expression for FDX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FDX2 Gene:

FDX2

SOURCE GeneReport for Unigene cluster for FDX2 Gene:

Hs.654865

mRNA Expression by UniProt/SwissProt for FDX2 Gene:

Q6P4F2-FDX2_HUMAN
Tissue specificity: Widely expressed, with highest levels in testis, kidney and brain (at protein level).

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FDX2 Gene

Orthologs for FDX2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FDX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDX1L 34 35
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia FDX1L 34 35
  • 86.89 (n)
dog
(Canis familiaris)
Mammalia FDX1L 34 35
  • 86.7 (n)
mouse
(Mus musculus)
Mammalia Fdx1l 34 16 35
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Fdx1l 34
  • 82.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fdx1l 34
  • 62.22 (n)
Str.7854 34
zebrafish
(Danio rerio)
Actinopterygii fdx1l 34 35
  • 71.61 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5955 34
fruit fly
(Drosophila melanogaster)
Insecta Fdxh 34 35
  • 63.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006799 34
  • 59.33 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y73F8A.27 34
  • 58.63 (n)
Y73F8A.27 35
  • 51 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL169C 34
  • 55.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAH1 34 35
  • 53.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10307g 34
  • 48.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MFDX1 34
  • 52.01 (n)
rice
(Oryza sativa)
Liliopsida Os09g0437900 34
  • 52.87 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07794 34
  • 52.05 (n)
Species where no ortholog for FDX2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FDX2 Gene

ENSEMBL:
Gene Tree for FDX2 (if available)
TreeFam:
Gene Tree for FDX2 (if available)

Paralogs for FDX2 Gene

Paralogs for FDX2 Gene

Pseudogenes.org Pseudogenes for FDX2 Gene

genes like me logo Genes that share paralogs with FDX2: view

Variants for FDX2 Gene

Sequence variations from dbSNP and Humsavar for FDX2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs587777600 Uncertain significance 10,315,996(+) GGCCA(A/T)GACAT downstream-variant-500B, reference, missense
rs10408438 -- 10,309,751(+) CCACG(C/T)TAGCC downstream-variant-500B, upstream-variant-2KB
rs1045384 -- 10,316,570(-) TCTGT(A/C)TGTGG upstream-variant-2KB, utr-variant-3-prime
rs1048941 -- 10,310,540(-) ACCCT(G/T)CCCAA upstream-variant-2KB, reference, synonymous-codon
rs111313038 -- 10,315,641(+) ACAGG(C/G)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FDX2 Gene

Variant ID Type Subtype PubMed ID
esv2667969 CNV deletion 23128226
nsv470124 CNV gain 18288195

Variation tolerance for FDX2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FDX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDX2 Gene

Disorders for FDX2 Gene

Relevant External Links for FDX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FDX2

No disorders were found for FDX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDX2 Gene

Publications for FDX2 Gene

  1. Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy. (PMID: 24281368) Spiegel R. … Elpeleg O. (Eur. J. Hum. Genet. 2013) 2 3 64
  2. Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. (PMID: 20547883) Sheftel A.D. … Lill R. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for FDX2 Gene

Sources for FDX2 Gene

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