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Aliases for FDX1L Gene

Aliases for FDX1L Gene

  • Ferredoxin 1-Like 2 3 5
  • FDX2 3 4
  • Ferredoxin-1-Like Protein 4

External Ids for FDX1L Gene

Previous GeneCards Identifiers for FDX1L Gene

  • GC19M010278
  • GC19M010281
  • GC19M010416
  • GC19M010001

Summaries for FDX1L Gene

Entrez Gene Summary for FDX1L Gene

  • This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]

GeneCards Summary for FDX1L Gene

FDX1L (Ferredoxin 1-Like) is a Protein Coding gene. Among its related pathways are Diseases of metabolism and Phase II conjugation. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is FDX1.

UniProtKB/Swiss-Prot for FDX1L Gene

  • Essential for heme A and Fe/S protein biosynthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDX1L Gene

Genomics for FDX1L Gene

Regulatory Elements for FDX1L Gene

Promoters for FDX1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FDX1L on UCSC Golden Path with GeneCards custom track

Genomic Location for FDX1L Gene

10,310,045 bp from pter
10,316,015 bp from pter
5,971 bases
Minus strand

Genomic View for FDX1L Gene

Genes around FDX1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDX1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDX1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDX1L Gene

Proteins for FDX1L Gene

  • Protein details for FDX1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adrenodoxin-like protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8N8B8

    Protein attributes for FDX1L Gene

    183 amino acids
    Molecular mass:
    19521 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FDX1L Gene

    Alternative splice isoforms for FDX1L Gene


neXtProt entry for FDX1L Gene

Proteomics data for FDX1L Gene at MOPED

Post-translational modifications for FDX1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDX1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDX1L Gene

Domains & Families for FDX1L Gene

Protein Domains for FDX1L Gene

Suggested Antigen Peptide Sequences for FDX1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 2Fe-2S ferredoxin-type domain.
  • Belongs to the adrenodoxin/putidaredoxin family.
  • Contains 1 2Fe-2S ferredoxin-type domain.
  • Belongs to the adrenodoxin/putidaredoxin family.
genes like me logo Genes that share domains with FDX1L: view

No data available for Gene Families for FDX1L Gene

Function for FDX1L Gene

Molecular function for FDX1L Gene

UniProtKB/Swiss-Prot Function:
Essential for heme A and Fe/S protein biosynthesis.

Phenotypes for FDX1L Gene

GenomeRNAi human phenotypes for FDX1L:
genes like me logo Genes that share phenotypes with FDX1L: view

Animal Model Products

miRNA for FDX1L Gene

miRTarBase miRNAs that target FDX1L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FDX1L Gene

Localization for FDX1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDX1L Gene

Mitochondrion. Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for FDX1L Gene COMPARTMENTS Subcellular localization image for FDX1L gene
Compartment Confidence
mitochondrion 5
chloroplast 2

No data available for Gene Ontology (GO) - Cellular Components for FDX1L Gene

Pathways & Interactions for FDX1L Gene

genes like me logo Genes that share pathways with FDX1L: view

Gene Ontology (GO) - Biological Process for FDX1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FDX1L: view

No data available for SIGNOR curated interactions for FDX1L Gene

Drugs & Compounds for FDX1L Gene

No Compound Related Data Available

Transcripts for FDX1L Gene

Unigene Clusters for FDX1L Gene

Ferredoxin 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FDX1L Gene

No ASD Table

Relevant External Links for FDX1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FDX1L Gene

mRNA expression in normal human tissues for FDX1L Gene

Protein differential expression in normal tissues from HIPED for FDX1L Gene

This gene is overexpressed in Heart (23.6) and Pancreas (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FDX1L Gene

SOURCE GeneReport for Unigene cluster for FDX1L Gene Hs.654865

mRNA Expression by UniProt/SwissProt for FDX1L Gene

Tissue specificity: Widely expressed, with highest levels in testis, kidney and brain (at protein level).
genes like me logo Genes that share expression patterns with FDX1L: view

Protein tissue co-expression partners for FDX1L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FDX1L Gene

Orthologs for FDX1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FDX1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FDX1L 35
  • 86.89 (n)
  • 89.07 (a)
FDX1L 36
  • 88 (a)
(Canis familiaris)
Mammalia FDX1L 35
  • 86.7 (n)
  • 89.62 (a)
FDX1L 36
  • 88 (a)
(Mus musculus)
Mammalia Fdx1l 35
  • 83.14 (n)
  • 83.91 (a)
Fdx1l 16
Fdx1l 36
  • 80 (a)
(Pan troglodytes)
Mammalia FDX1L 35
  • 98.91 (n)
  • 98.91 (a)
FDX1L 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fdx1l 35
  • 82.18 (n)
  • 85.06 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fdx1l 35
  • 62.22 (n)
  • 62.78 (a)
Str.7854 35
(Danio rerio)
Actinopterygii fdx1l 35
  • 71.61 (n)
  • 80.47 (a)
fdx1l 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5955 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006799 35
  • 59.33 (n)
  • 57.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fdxh 35
  • 63.31 (n)
  • 59.71 (a)
Fdxh 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y73F8A.27 35
  • 58.63 (n)
  • 58.16 (a)
Y73F8A.27 36
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL169C 35
  • 55.45 (n)
  • 45.45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10307g 35
  • 48.18 (n)
  • 44.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAH1 35
  • 53.94 (n)
  • 45.45 (a)
YAH1 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MFDX1 35
  • 52.01 (n)
  • 53.45 (a)
(Oryza sativa)
Liliopsida Os09g0437900 35
  • 52.87 (n)
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07794 35
  • 52.05 (n)
  • 42.47 (a)
Species with no ortholog for FDX1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FDX1L Gene

Gene Tree for FDX1L (if available)
Gene Tree for FDX1L (if available)

Paralogs for FDX1L Gene

Paralogs for FDX1L Gene

(1) SIMAP similar genes for FDX1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FDX1L: view

Variants for FDX1L Gene

Sequence variations from dbSNP and Humsavar for FDX1L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12976540 -- 10,315,318(+) TTGTG(G/T)GTTTT intron-variant
rs7408715 -- 10,314,235(+) tgcct(C/T)ggcct intron-variant
rs8101195 -- 10,313,139(+) tctca(A/G)ataaa intron-variant
rs8101365 -- 10,312,563(+) agtcc(C/T)gctct intron-variant
rs8101473 -- 10,312,662(+) cagag(C/T)agctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FDX1L Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
esv2667969 CNV Deletion 23128226
nsv911040 CNV Loss 21882294

Variation tolerance for FDX1L Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDX1L Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDX1L Gene

Disorders for FDX1L Gene

Relevant External Links for FDX1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FDX1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDX1L Gene

Publications for FDX1L Gene

  1. Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. (PMID: 20547883) Sheftel A.D. … Lill R. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Human ferredoxin-2 displays a unique conformational change. (PMID: 23208207) Qi W. … Cowan J.A. (Dalton Trans 2013) 3
  5. Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy. (PMID: 24281368) Spiegel R. … Elpeleg O. (Eur. J. Hum. Genet. 2013) 3

Products for FDX1L Gene

Sources for FDX1L Gene