FDX1L Gene
protein-coding GIFtS: 47
GCID: GC19M010416
|
|
ferredoxin 1-like
| |
Aliases
for FDX1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ferredoxin 1-Like1 2 | | Ferredoxin-1-Like Protein2 3 | | MGC196041 | | FDX22 | | Adrenodoxin-Like Protein, Mitochondrial2 |
Export aliases for FDX1L gene to outside databasesPrevious GC identifers: GC19M010278 GC19M010281 GC19M010001 |
Summaries
for FDX1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ADXL_HUMAN, Q6P4F2Function: Essential for heme A and Fe/S protein biosynthesis
|
Genomic Views
for FDX1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FDX1L gene promoter:
PPAR-gamma1 Sp1 AP-2beta AP-2gamma AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for FDX1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDX1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2FDX1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M010416: view genomic region
(about GC identifiers)
Start:
|
10,416,103 bp from pter |
End:
|
10,426,691 bp from pter |
Size:
|
10,589 bases |
Orientation:
|
minus strand |
|
Proteins
for FDX1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADXL_HUMAN, Q6P4F2 (See
protein sequence)Recommended Name: Adrenodoxin-like protein, mitochondrial precursor Size: 183 amino acids; 19521 Da
Cofactor: Binds 1 2Fe-2S cluster (By similarity)
Subcellular location: Mitochondrion. Mitochondrion matrix (By similarity)
1 PDB 3D structure from  and Proteopedia  for FDX1L:2Y5C (3D)
Explore the universe of human proteins at neXtProt for FDX1L: NX_Q6P4F2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P4F2
FDX1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001026904.1
ENSEMBL proteins: ENSP00000408510 ENSP00000468746 ENSP00000441093 Reactome Protein details: Q6P4F2
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005759 | mitochondrial matrix |
IEA | -- |
FDX1L for ontologies About GeneDecksing
FDX1L Antibody Products:
Assay Products for FDX1L: |
Protein
Domains /
Families
for FDX1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FDX1L for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P4F2ProtoNet protein and cluster: Q6P4F2 2 Blocks protein families: IPB001041 Ferredoxin IPB001055 Adrenodoxin
UniProtKB/Swiss-Prot: ADXL_HUMAN, Q6P4F2Similarity: Belongs to the adrenodoxin/putidaredoxin familySimilarity: Contains 1 2Fe-2S ferredoxin-type domain |
Function
for FDX1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADXL_HUMAN, Q6P4F2Function: Essential for heme A and Fe/S protein biosynthesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDX1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDX1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FDX1L (NM_001031734) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FDX1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDX1L |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009055 | electron carrier activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- | | GO:0051537 | 2 iron, 2 sulfur cluster binding |
IEA | -- |
FDX1L for ontologies About GeneDecksing
|
Pathways & Interactions
for FDX1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Iron-Sulfur Cluster Biogenesis | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for FDX1L
FDX1L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FDX1L
3 Interacting proteins for FDX1L (Q6P4F23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022900 | electron transport chain |
IEA | -- |
FDX1L for ontologies About GeneDecksing
|
Drugs & Compounds
for FDX1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FDX1L
Search CenterWatch for drugs/clinical trials and news about FDX1L / ADXL
|
Transcripts
for FDX1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FDX1L gene (2 alternative transcripts): NM_080665.3 NM_001031734.2 Unigene Cluster for FDX1L: Ferredoxin 1-like Hs.654865 [show with all ESTs]Unigene Representative Sequence: AL5246084 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452032 ENST00000493771 ENST00000591626 ENST00000541276(uc002mnx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDX1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDX1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FDX1L (NM_001031734) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FDX1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDX1L |
Additional cDNA sequence: AK300568.1 BC010155.2 BC063460.1 11 DOTS entries: DT.212385 DT.121422214 DT.100782700 DT.100782699 DT.100024418 DT.95374300 DT.92420928 DT.121422192 DT.97841891 DT.99960882 DT.100037615 24/529 AceView cDNA sequences (see all 529): BC044225 BX282435 AI498122 BM675275 BM310518 AI080260 CF135584 BF724596 BQ233371 CR597964 AA354247 BC034409 BX353652 BQ086373 BM713265 BM926198 BQ430683 CA424713 BQ677994 BQ066216 AI289404 CD557260 BU732531 CA426759
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FDX1L (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i | · | 6j | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | |
ECgene alternative splicing isoforms for FDX1L
|
Expression
for FDX1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FDX1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGGCTCT
About this image
See FDX1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FDX1L
SOURCE GeneReport for Unigene cluster: Hs.654865
UniProtKB/Swiss-Prot: ADXL_HUMAN, Q6P4F2Tissue specificity: Widely expressed, with highest levels in testis, kidney and brain (at protein level)
SABiosciences Custom PCR Arrays for FDX1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FDX1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FDX1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDX1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDX1L |
Orthologs
for FDX1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FDX1L gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for FDX1L (if available)
TreeFam Gene Tree for FDX1L (if available) |
Paralogs
for FDX1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FDX1L gene
- FDX12
1 SIMAP similar gene for FDX1L using alignment to 1 protein entry: ADXL_HUMAN:FDX1
FDX1L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FDX1L
PGOHUM00000245273
|
Genomic Variants
for FDX1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FDX1L (10416103 - 10426691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FDX1L
1 CNV: 29685 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FDX1L |
|
Disorders
/ Diseases
for FDX1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FDX1L for disorders About GeneDecksing
OMIM gene information: 614585
OMIM disorders: --
1  disease for FDX1L: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: FDX1L (1 document)
Export disorders for FDX1L gene to outside databases
|
Publications
for FDX1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FDX1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with FDX1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Humans possess two mitochondrial ferredoxins, Fdx1 an d Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynth esis. (PubMed id 20547883)2 Sheftel A.D....Lill R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for FDX1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FDX1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FDX1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FDX1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FDX1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FDX1L gene:
Search GeneIP for patents involving FDX1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FDX1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FDX1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FDX1L | | | OriGene Protein Over-expression Lysate for FDX1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FDX1L | | OriGene 3'-UTR Clone for FDX1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDX1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDX1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FDX1L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FDX1L | | OriGene Custom Protein Services for FDX1L | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FDX1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FDX1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDX1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDX1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDX1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDX1L |
| |
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 | | | FDX1L Proteins, Antibodies, CLIAs, and ELISAs |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDX1L |
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