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Aliases for FDX1L Gene

Aliases for FDX1L Gene

  • Ferredoxin 1-Like 2 3
  • FDX2 3 4 6
  • Adrenodoxin-Like Protein, Mitochondrial 3
  • Ferredoxin-1-Like Protein 4

External Ids for FDX1L Gene

Previous GeneCards Identifiers for FDX1L Gene

  • GC19M010278
  • GC19M010281
  • GC19M010416
  • GC19M010001

Summaries for FDX1L Gene

Entrez Gene Summary for FDX1L Gene

  • This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]

GeneCards Summary for FDX1L Gene

FDX1L (Ferredoxin 1-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial Iron-Sulfur Cluster Biogenesis. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is FDX1.

UniProtKB/Swiss-Prot for FDX1L Gene

  • Essential for heme A and Fe/S protein biosynthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDX1L Gene

Genomics for FDX1L Gene

Regulatory Elements for FDX1L Gene

Genomic Location for FDX1L Gene

10,310,045 bp from pter
10,316,015 bp from pter
5,971 bases
Minus strand

Genomic View for FDX1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FDX1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDX1L Gene

Proteins for FDX1L Gene

  • Protein details for FDX1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adrenodoxin-like protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8N8B8

    Protein attributes for FDX1L Gene

    183 amino acids
    Molecular mass:
    19521 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 1 [2Fe-2S] cluster.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FDX1L Gene

    Alternative splice isoforms for FDX1L Gene


neXtProt entry for FDX1L Gene

Proteomics data for FDX1L Gene at MOPED

Post-translational modifications for FDX1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDX1L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FDX1L Gene

Domains for FDX1L Gene

Protein Domains for FDX1L Gene

Suggested Antigen Peptide Sequences for FDX1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 2Fe-2S ferredoxin-type domain.
  • Belongs to the adrenodoxin/putidaredoxin family.
  • Contains 1 2Fe-2S ferredoxin-type domain.
  • Belongs to the adrenodoxin/putidaredoxin family.
genes like me logo Genes that share domains with FDX1L: view

No data available for Gene Families for FDX1L Gene

Function for FDX1L Gene

Molecular function for FDX1L Gene

UniProtKB/Swiss-Prot Function:
Essential for heme A and Fe/S protein biosynthesis.

Gene Ontology (GO) - Molecular Function for FDX1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0009055 electron carrier activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with FDX1L: view

Animal Model Products

miRNA for FDX1L Gene

miRTarBase miRNAs that target FDX1L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDX1L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FDX1L Gene

Localization for FDX1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDX1L Gene

Mitochondrion. Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for FDX1L Gene COMPARTMENTS Subcellular localization image for FDX1L gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FDX1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FDX1L: view

Pathways for FDX1L Gene

genes like me logo Genes that share pathways with FDX1L: view

Pathways by source for FDX1L Gene

Gene Ontology (GO) - Biological Process for FDX1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process TAS --
GO:0016125 sterol metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FDX1L: view

Transcripts for FDX1L Gene

Unigene Clusters for FDX1L Gene

Ferredoxin 1-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDX1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDX1L Gene

No ASD Table

Relevant External Links for FDX1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FDX1L Gene

mRNA expression in normal human tissues for FDX1L Gene

Protein differential expression in normal tissues for FDX1L Gene

This gene is overexpressed in Heart (23.6) and Pancreas (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FDX1L Gene

SOURCE GeneReport for Unigene cluster for FDX1L Gene Hs.654865

mRNA Expression by UniProt/SwissProt for FDX1L Gene

Tissue specificity: Widely expressed, with highest levels in testis, kidney and brain (at protein level).
genes like me logo Genes that share expressions with FDX1L: view

Expression partners for FDX1L Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FDX1L Gene

Orthologs for FDX1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FDX1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FDX1L 35
  • 86.89 (n)
  • 89.07 (a)
FDX1L 36
  • 88 (a)
(Canis familiaris)
Mammalia FDX1L 35
  • 86.7 (n)
  • 89.62 (a)
FDX1L 36
  • 88 (a)
(Mus musculus)
Mammalia Fdx1l 35
  • 83.14 (n)
  • 83.91 (a)
Fdx1l 16
Fdx1l 36
  • 80 (a)
(Pan troglodytes)
Mammalia FDX1L 35
  • 98.91 (n)
  • 98.91 (a)
FDX1L 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fdx1l 35
  • 82.18 (n)
  • 85.06 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fdx1l 35
  • 62.22 (n)
  • 62.78 (a)
Str.7854 35
(Danio rerio)
Actinopterygii fdx1l 35
  • 71.61 (n)
  • 80.47 (a)
fdx1l 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5955 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006799 35
  • 59.33 (n)
  • 57.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fdxh 35
  • 63.31 (n)
  • 59.71 (a)
Fdxh 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y73F8A.27 35
  • 58.63 (n)
  • 58.16 (a)
Y73F8A.27 36
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL169C 35
  • 55.45 (n)
  • 45.45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10307g 35
  • 48.18 (n)
  • 44.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAH1 35
  • 53.94 (n)
  • 45.45 (a)
YAH1 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MFDX1 35
  • 52.01 (n)
  • 53.45 (a)
(Oryza sativa)
Liliopsida Os09g0437900 35
  • 52.87 (n)
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07794 35
  • 52.05 (n)
  • 42.47 (a)
Species with no ortholog for FDX1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FDX1L Gene

Gene Tree for FDX1L (if available)
Gene Tree for FDX1L (if available)

Paralogs for FDX1L Gene

Paralogs for FDX1L Gene

(1) SIMAP similar genes for FDX1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FDX1L: view

Variants for FDX1L Gene

Sequence variations from dbSNP and Humsavar for FDX1L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs368835 -- 10,315,310(+) CACCT(A/G)ATTTG intron-variant
rs430092 -- 10,314,275(+) cactg(C/T)gcctg intron-variant
rs1124765 -- 10,315,348(-) CTTAT(A/C)CATTT intron-variant
rs2358583 -- 10,315,319(+) TGTGG(G/T)TTTTT intron-variant
rs4389248 -- 10,311,892(+) tgagg(G/T)ggagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FDX1L Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
esv2667969 CNV Deletion 23128226
nsv911040 CNV Loss 21882294

Relevant External Links for FDX1L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDX1L Gene

Disorders for FDX1L Gene

Relevant External Links for FDX1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FDX1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FDX1L Gene

Publications for FDX1L Gene

  1. Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. (PMID: 20547883) Sheftel A.D. … Lill R. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FDX1L Gene

Sources for FDX1L Gene

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