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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FDX1 Gene

protein-coding GIFtS: 57
GCID: GC11P110334

ferredoxin 1

(Previous symbol: FDX)

Explore 17 diseases affiliated with
FDX1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ferredoxin 1¹ ²		Ferredoxin-1³
ADX¹ ² ³ ⁵		Hepatoredoxin³
FDX¹ ²		Mitochondrial Adrenodoxin²
Adrenal Ferredoxin² ³		Ferredoxin-1³
LOH11CR1D²		Hepatoredoxin³
Adrenodoxin, Mitochondrial²

External Ids:	HGNC: 3638¹	Entrez Gene: 2230²	Ensembl: ENSG00000137714⁷	OMIM: 103260⁵	UniProtKB: P10109³

Export aliases for FDX1 gene to outside databases

Previous GC identifers: GC11P112572 GC11P111771 GC11P109838 GC11P109805 GC11P106225

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FDX1:

This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to

mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this

functional gene are found on chromosomes 20 and 21. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ADX_HUMAN, P10109

Function: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones,

participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from

adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme

Gene Wiki entry for FDX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FDX1 gene promoter:
Sp1 Pbx1a C/EBPalpha GATA-1 FAC1 FOXJ2 (long isoform) FOXO1a FOXJ2 Pax-4a FOXO1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FDX1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDX1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

FDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDX1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P110334: view genomic region (about GC identifiers)

Start:	110,300,594 bp from pter	End:	110,335,605 bp from pter
Size:	35,012 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADX_HUMAN, P10109 (See protein sequence)

Recommended Name: Adrenodoxin, mitochondrial precursor

Size: 184 amino acids; 19393 Da

Cofactor: Binds 1 2Fe-2S cluster

Subcellular location: Mitochondrion matrix

5 PDB 3D structures from and Proteopedia for FDX1:

3N9Y (3D)

3N9Z (3D)

3NA0 (3D)

3NA1 (3D)

3P1M (3D)

Secondary accessions: B0YJ14 Q53YD6

Explore the universe of human proteins at neXtProt for FDX1: NX_P10109

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10109

FDX1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004100.1

ENSEMBL proteins:

ENSP00000260270

Reactome Protein details: P10109
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for FDX1
	Uscn Proteins for FDX1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005759	mitochondrial matrix	IEA	--
GO:0030061	mitochondrial crista	--	--

FDX1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FDX1 for domains About GeneDecksing

4 InterPro domains/families:

IPR012675 Beta-grasp_dom

IPR001055 Adrenodoxin

IPR018298 Adrenodoxin_Fe-S_BS

IPR001041 2Fe-2S_ferredoxin-type

Graphical View of Domain Structure for InterPro Entry P10109

ProtoNet protein and cluster: P10109

2 Blocks protein families:

IPB001041 Ferredoxin

IPB001055 Adrenodoxin

UniProtKB/Swiss-Prot: ADX_HUMAN, P10109

Similarity: Belongs to the adrenodoxin/putidaredoxin family

Similarity: Contains 1 2Fe-2S ferredoxin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADX_HUMAN, P10109

Function: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones,

participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from

adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme

Biophysicochemical properties: Redox potential: E(0) is -448 mV;

Genatlas biochemistry entry for FDX1:

ferredoxin,ion sulfur electron transport protein for mitochondrial P450s

miRNA Products:		OriGene 3'-UTR Clone: FDX1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDX1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate FDX1 (see all 10):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3653 hsa-miR-944 hsa-miR-4282 hsa-miR-340 hsa-miR-3647-3p hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: FDX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for FDX1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDX1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	TAS	2969697
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	--	--
GO:0009055	electron carrier activity	IEA	--
GO:0015039	NADPH-adrenodoxin reductase activity	--	--
GO:0019899	enzyme binding	--	--

FDX1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mitochondrial Iron-Sulfur Cluster Biogenesis

	Mitochondrial Iron-Sulfur Cluster Biogenesis	1.00			Electron Transport from NADPH to Ferredoxin	0.33
	FXN:NFS1:ISD11:ISCU Synthesizes Iron-Sulfur Cluster	0.67

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for FDX1

	Mitochondrial Iron-Sulfur Cluster Biogenesis
	Metabolism
	Electron Transport from NADPH to Ferredoxin
	FXN:NFS1:ISD11:ISCU Synthesizes Iron-Sulfur Cluster

FDX1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FDX1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for FDX1 (P10109³ ENSP00000260270⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP11B2	P19099³, ENSP00000325822⁴	I2D: score=1 STRING: ENSP00000325822
CYP11A1	P05108³, ENSP00000268053⁴	I2D: score=2 STRING: ENSP00000268053
FDXR	P22570³, ENSP00000293195⁴	I2D: score=1 STRING: ENSP00000293195
CYCS	P99999³, ENSP00000307786⁴	I2D: score=1 STRING: ENSP00000307786
NR4A2	P43354³	I2D: score=1

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006091	generation of precursor metabolites and energy	TAS	2969697
GO:0022900	electron transport chain	IEA	--
GO:0030325	adrenal gland development	--	--
GO:0034698	response to gonadotropin stimulus	--	--
GO:0044320	cellular response to leptin stimulus	--	--

FDX1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FDX1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FDX1

1 DrugBank Compound for FDX1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Mitotane	--	53-19-0	target	unknown	11159707 3770229 9118466

10/37 Novoseek chemical compound relationships for FDX1 gene (see all 37) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
putidaredoxin	79.8	5	10220356 (2), 9675270 (1), 10899784 (1)
22r-hydroxycholesterol	79.6	3	8947841 (2), 2292341 (1)
18-hydroxycorticosterone	75.1	2	10411633 (1), 10491169 (1)
steroid	68.1	28	11841224 (2), 11053423 (1), 11726279 (1), 16137649 (1) (see all 16)
iron-sulfur	67.2	15	11726279 (1), 17499976 (1), 8425475 (1), 8517924 (1) (see all 10)
doca	64.7	1	18178501 (1)
cholesterol	61.7	38	1425418 (2), 19317426 (2), 10103006 (2), 1793433 (1) (see all 25)
nadph	56.4	34	2294024 (4), 2078639 (2), 15340917 (2), 8799343 (1) (see all 15)
3beta-hydroxysteroid	54.5	6	2292341 (1), 16139340 (1), 9030872 (1), 12768545 (1)
sterol	54.1	6	9790667 (1), 8950197 (1), 1661294 (1), 1425418 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about FDX1 / ADX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FDX1 gene:

NM_004109.4

Unigene Cluster for FDX1:

Ferredoxin 1

Hs.744 [show with all ESTs]

Unigene Representative Sequence: NM_004109

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000260270(uc001pkx.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDX1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate FDX1 (see all 10):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3653 hsa-miR-944 hsa-miR-4282 hsa-miR-340 hsa-miR-3647-3p hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: FDX1 3' UTR sequence

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Additional cDNA sequence:

AB096243.1 BC010284.1 BC017063.1 BT006681.1 J03548.1 M18003.1 M34788.1

7 DOTS entries:

DT.214815 DT.120754302 DT.100759997 DT.91979097 DT.100789367 DT.92415116 DT.92429110

24/173 AceView cDNA sequences (see all 173):

BC017063 BI822600 NM_004109 CA394895 CR607314 CR611214 CR620794 AI810995

CA431948 BQ083897 CB529217 CR626036 BM052958 AI383320 BQ685101 CD678489

AV704377 BM714049 CD367282 AV708401 AA774562 CA309903 AV708262 BM675234

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FDX1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4
SP1:
SP2:

ECgene alternative splicing isoforms for FDX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FDX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAGTGGA

About this image

FDX1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FDX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FDX1

SOURCE GeneReport for Unigene cluster: Hs.744

UniProtKB/Swiss-Prot: ADX_HUMAN, P10109

Tissue specificity: Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at

protein level)

SABiosciences Custom PCR Arrays for FDX1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for FDX1 gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FDX1¹	ferredoxin 1	75.62(n) 77.71(a)		373947 NM_001198668.1 NP_001185597.1
lizard (Anolis carolinensis)	Reptilia	FDX1⁶ FDX1L⁶	--	82(a) 39(a)	1 ↔ 1 possible ortholog	3(186492777-186494832) 2(27778125-27781883)
African clawed frog (Xenopus laevis)	Amphibia	AW646341.1²	--	79(n)		AW646341.1
zebrafish (Danio rerio)	Actinopterygii	Dr.13680²	Transcribed sequence with weak similarity to protein more	74.34(n)		BQ617988.1
fruit fly (Drosophila melanogaster)	Insecta	CG1319¹	CG1319	57.33(n) 59.2(a)		38530 NM_139632.2 NP_647889.2
worm (Caenorhabditis elegans)	Secernentea	Y73F8A.27⁶	--	29(a)	possible ortholog	IV(15472775-15473798)
thale cress (Arabidopsis thaliana)	eudicotyledons	MFDX1⁶ ATMFDX2⁶	ferredoxin 2	31(a) 29(a)	possible ortholog possible ortholog	4(2758653-2760912) 4(11256459-11258588)
rice (Oryza sativa)	Liliopsida	-- --	2Fe-2S iron-sulfur cluster binding domain containi... 2Fe-2S iron-sulfur cluster binding domain containi...	35(a) 35(a)	possible ortholog possible ortholog	7(562346-565055) 9(16170154-16174737)
E. coli (Escherichia coli)	Gamma proteobacteria	fdx⁶	[2Fe-2S] ferredoxin	27(a)	1 ↔ 1	Chromosome(2654770-2655105) b2525

ENSEMBL Gene Tree for FDX1 (if available)
TreeFam Gene Tree for FDX1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FDX1 gene

FDX1L²

1 SIMAP similar gene for FDX1 using alignment to 1 protein entry: ADX_HUMAN:

FDX1L

FDX1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for FDX1
PGOHUM00000247519 PGOHUM00000239159 PGOHUM00000235571

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35726307^1,2	C	--	106248832(+)	`TTTTT-/TCTTAA`	1	--	int¹		2		NA	4
rs145716035^1,2		--	110298758(+)	`CTTGAC/GCTCAG`	1	--	us2k¹		0	--	--	--	--
rs114250632^1,2	F,	--	110299099(+)	`CATCAA/GTTTAT`	1	--	us2k¹		1		WA	118
rs17111207^1,2	C,F,H,	--	110299117(+)	`TATTTA/GTTAGA`	1	--	us2k¹		18		NA NS EA CSA WA	1962
rs185322742^1,2		--	110299203(+)	`GTGTAC/TGAATA`	1	--	us2k¹		0	--	--	--	--
rs34558864^1,2	C,	--	110299365(+)	`TTACTA/-AAAAA`	1	--	us2k¹		1		CSA	2
rs3782053^1,2	C,F,H,	--	110299371(+)	`AAAAAA/CAAAAG`	1	--	us2k¹		8		NS EA WA NA	816
rs190528692^1,2		--	110299431(+)	`CTGTGC/TCCTTC`	1	--	us2k¹		0	--	--	--	--
rs3759018^1,2	C,F,A,H,	--	110299437(+)	`CCTTCG/ACAGCT`	1	--	us2k¹		18		NS EA NA	2226
rs73564121^1,2	C,	--	110299469(+)	`AACGAC/TTTGAG`	1	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for FDX1 (110300594 - 110335605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FDX1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FDX1 for disorders           About GeneDecksing

OMIM gene information: 103260    OMIM disorders: --

17 diseases for FDX1:    About MalaCards

vitamin d-dependent rickets, type i lipoid adrenal hyperplasia cerebrotendinous xanthomatosis xanthomatosis

congenital adrenal insufficiency adrenal hyperplasia rickets hypospadias

choriocarcinoma oligodendroglioma aldosteronism lung cancer

adenoma cholesterol tuberculosis thyroiditis

mycobacterium tuberculosis

2 diseases from the University of Copenhagen DISEASES database for FDX1:

Cerebrotendinous xanthomatosis Congenital adrenal insufficiency

2 Novoseek disease relationships for FDX1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
xanthomatosis cerebrotendinous	68.9	1	8950197 (1)
choriocarcinoma	32.4	1	1316854 (1)

Human Genome Epidemiology (HuGE) Navigator: FDX1 (4 documents)

Export disorders for FDX1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FDX1 gene, integrated from 9 sources (see all 165):
(articles sorted by number of sources associating them with FDX1)

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Molecular cloning and sequence analysis of human placental ferredoxin. (PubMed id 2969697)^{1, 2, 3} Mittal S.... Vickery L.E. (1988)
Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode. (PubMed id 12699818)^{1, 2, 9} Johnson D.... Martin L.L. (2003)
Humans possess two mitochondrial ferredoxins, Fdx1 an d Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynth esis. (PubMed id 20547883)^{1, 2} Sheftel A.D....Lill R. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins. (PubMed id 1909889)^{1, 2} Skjeldal L.... Vickery L.E. (1991)
Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family. (PubMed id 2340092)^{1, 2} Chang C.-Y.... Chung B.-C. (1990)
Cloning and structure of the human adrenodoxin gene. (PubMed id 3229285)^{1, 2} Chang C.-Y.... Chung B.-C. (1988)
Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells. (PubMed id 3343244)^{1, 2} Picado-Leonard J.... Miller W.L. (1988)
Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s. (PubMed id 17188650)^{1, 9} Pechurskaya T.A....Usanov S.A. (2007)
Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria. (PubMed id 15927889)^{1, 9} Derouet-Humbert E....Bureik M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2230	HGNC: 3638	AceView: FDX1	Ensembl:ENSG00000137714	euGenes: HUgn2230
ECgene: FDX1	H-InvDB: FDX1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FDX1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FDX1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FDX1 gene:
Search GeneIP for patents involving FDX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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