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FDX1 Gene

protein-coding   GIFtS: 60
GCID: GC11P110334

Ferredoxin 1


(Previous symbol: FDX)
  See FDX1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ferredoxin 11 2     Adrenodoxin, Mitochondrial2
ADX2 3 5     ferredoxin-12
FDX1 2     hepatoredoxin2
Adrenal Ferredoxin2 3     Mitochondrial Adrenodoxin2
adrenodoxin1     Ferredoxin-13
LOH11CR1D2     Hepatoredoxin3

External Ids:    HGNC: 36381   Entrez Gene: 22302   Ensembl: ENSG000001377147   OMIM: 1032605   UniProtKB: P101093   

Export aliases for FDX1 gene to outside databases

Previous GC identifers: GC11P112572 GC11P111771 GC11P109838 GC11P109805 GC11P106225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FDX1 Gene:
This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to
mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this
functional gene are found on chromosomes 20 and 21. (provided by RefSeq, Aug 2011)

GeneCards Summary for FDX1 Gene:
FDX1 (ferredoxin 1) is a protein-coding gene. Diseases associated with FDX1 include vitamin d-dependent rickets type i, and congenital adrenal insufficiency. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is FDX1L.

UniProtKB/Swiss-Prot: ADX_HUMAN, P10109
Function: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid
hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons
from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage

Gene Wiki entry for FDX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the FDX1 gene promoter:
         Sp1   Pbx1a   C/EBPalpha   GATA-1   FAC1   FOXJ2 (long isoform)   FOXO1a   FOXJ2   Pax-4a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FDX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FDX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

FDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDX1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P110334:  view genomic region     (about GC identifiers)

Start:
110,300,594 bp from pter      End:
110,335,605 bp from pter
Size:
35,012 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADX_HUMAN, P10109 (See protein sequence)
Recommended Name: Adrenodoxin, mitochondrial precursor  
Size: 184 amino acids; 19393 Da
Cofactor: Binds 1 2Fe-2S cluster
Subunit: Interacts with CYP11A1
5 PDB 3D structures from and Proteopedia for FDX1:
3N9Y (3D)        3N9Z (3D)        3NA0 (3D)        3NA1 (3D)        3P1M (3D)    
Secondary accessions: B0YJ14 Q53YD6

Explore the universe of human proteins at neXtProt for FDX1: NX_P10109

Explore proteomics data for FDX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FDX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004100.1  
    ENSEMBL proteins: 
     ENSP00000260270  
    Reactome Protein details: P10109

    FDX1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FDX1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012675 Beta-grasp_dom
     IPR001055 Adrenodoxin
     IPR018298 Adrenodoxin_Fe-S_BS
     IPR001041 2Fe-2S_ferredoxin-type

    Graphical View of Domain Structure for InterPro Entry P10109

    ProtoNet protein and cluster: P10109

    2 Blocks protein domains:
    IPB001041 Ferredoxin
    IPB001055 Adrenodoxin


    UniProtKB/Swiss-Prot: ADX_HUMAN, P10109
    Similarity: Belongs to the adrenodoxin/putidaredoxin family
    Similarity: Contains 1 2Fe-2S ferredoxin-type domain


    Find genes that share domains with FDX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADX_HUMAN, P10109
    Function: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid
    hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons
    from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage
    Biophysicochemical properties: Redox potential: E(0) is -448 mV;

         Genatlas biochemistry entry for FDX1:
    ferredoxin,ion sulfur electron transport protein for mitochondrial P450s

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding TAS2969697
    GO:0009055electron carrier activity IDA--
    GO:0051536iron-sulfur cluster binding ----
    GO:00515372 iron, 2 sulfur cluster binding IDA--
         
    Find genes that share ontologies with FDX1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FDX1

    miRNA
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    miRTarBase miRNAs that target FDX1:
    hsa-mir-455-3p (MIRT037813), hsa-mir-30a-5p (MIRT028451)

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    Selected qRT-PCR Assays for microRNAs that regulate FDX1 (see all 10):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3653 hsa-miR-944 hsa-miR-4282 hsa-miR-340 hsa-miR-3647-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFDX1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for FDX1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADX_HUMAN, P10109: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    endoplasmic reticulum1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with FDX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FDX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitochondrial Iron-Sulfur Cluster Biogenesis
    Mitochondrial Iron-Sulfur Cluster Biogenesis
    Electron Transport from NADPH to Ferredoxin0.00
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with FDX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for FDX1
        Mitochondrial iron-sulfur cluster biogenesis
    Electron transport from NADPH to Ferredoxin


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FDX1
    Interactions:

        GeneGlobe Interaction Network for FDX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FDX1 (P101093 ENSP000002602704) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP11B2P190993, ENSP000003258224I2D: score=1 STRING: ENSP00000325822
    CYP11A1P051083, ENSP000002680534I2D: score=2 STRING: ENSP00000268053
    CYCSP999993, ENSP000003077864I2D: score=1 STRING: ENSP00000307786
    FDXRP225703, ENSP000002931954I2D: score=1 STRING: ENSP00000293195
    NR4A2P433543I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006694steroid biosynthetic process IEA--
    GO:0008203cholesterol metabolic process IDA--
    GO:0042446hormone biosynthetic process IDA--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process IEA--

    Find genes that share ontologies with FDX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FDX1 (ADX)

    1 DrugBank Compound for FDX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Mitotane-- 53-19-0targetunknown11159707 3770229 9118466

    Selected Novoseek inferred chemical compound relationships for FDX1 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    putidaredoxin 79.8 5 10220356 (2), 9675270 (1), 10899784 (1)
    22r-hydroxycholesterol 79.6 3 8947841 (2), 2292341 (1)
    18-hydroxycorticosterone 75.1 2 10411633 (1), 10491169 (1)
    steroid 68.1 28 11841224 (2), 11053423 (1), 11726279 (1), 16137649 (1) (see all 16)
    iron-sulfur 67.2 15 11726279 (1), 17499976 (1), 8425475 (1), 8517924 (1) (see all 10)
    doca 64.7 1 18178501 (1)
    cholesterol 61.7 38 1425418 (2), 19317426 (2), 10103006 (2), 1793433 (1) (see all 25)
    nadph 56.4 34 2294024 (4), 2078639 (2), 15340917 (2), 8799343 (1) (see all 15)
    3beta-hydroxysteroid 54.5 6 2292341 (1), 16139340 (1), 9030872 (1), 12768545 (1)
    sterol 54.1 6 9790667 (1), 8950197 (1), 1661294 (1), 1425418 (1) (see all 6)



    Find genes that share compounds with FDX1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FDX1 gene: 
    NM_004109.4  

    Unigene Cluster for FDX1:

    Ferredoxin 1
    Hs.744  [show with all ESTs]
    Unigene Representative Sequence: NM_004109
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260270(uc001pkx.3)
    miRNA
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    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3653 hsa-miR-944 hsa-miR-4282 hsa-miR-340 hsa-miR-3647-3p hsa-miR-570
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    Additional mRNA sequence: 

    AB096243.1 BC010284.1 BC017063.1 BT006681.1 J03548.1 M18003.1 M34788.1 

    7 DOTS entries:

    DT.214815  DT.120754302  DT.100759997  DT.91979097  DT.100789367  DT.92415116  DT.92429110 

    Selected AceView cDNA sequences (see all 173):

    BM052958 AI383320 BC010284 CD672343 CA431948 F02515 CD678489 CR611214 
    NM_004109 AA774562 BX356421 BQ083897 BQ771695 CB529217 CR598979 BM675234 
    AV708401 BQ685101 CA394895 CR607314 AV704377 CR620794 AI620225 CD367282 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FDX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for FDX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FDX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAGTGGA
    FDX1 Expression
    About this image


    FDX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
     
     Adrenal Gland (Endocrine System)
    FDX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FDX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.744

    UniProtKB/Swiss-Prot: ADX_HUMAN, P10109
    Tissue specificity: Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at
    protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FDX1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fdx11 , 5 ferredoxin 11, 5 77.36(n)1
    77.72(a)1
      9 (28.62 cM)5
    141481  NM_007996.11  NP_032022.11 
     519433075 
    chicken
    (Gallus gallus)
    Aves FDX11 ferredoxin 1 76.25(n)
    79.31(a)
      373947  NM_001198668.1  NP_001185597.1 
    lizard
    (Anolis carolinensis)
    Reptilia FDX16
    ferredoxin 1
    68(a)
    1 ↔ 1
    3(186481958-186494838)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW646341.12   -- 79(n)    AW646341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136802 Transcribed sequence with weak similarity to protein more 74.34(n)    BQ617988.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13191 CG1319 61.01(n)
    63.39(a)
      38530  NM_139632.3  NP_647889.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAH16
    Ferredoxin of the mitochondrial matrix required fo...
    32(a)
    1 → many
    XVI(73363-73881) YPL252C


    ENSEMBL Gene Tree for FDX1 (if available)
    TreeFam Gene Tree for FDX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FDX1 gene
    FDX1L2  ENSG000001678072  
    1 SIMAP similar gene for FDX1 using alignment to 1 protein entry:     ADX_HUMAN:
    FDX1L

    Find genes that share paralogs with FDX1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for FDX1
    PGOHUM00000247519 PGOHUM00000239159 PGOHUM00000235571


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FDX1 (see all 809)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457160351,2
    --110298758(+) CTTGAC/GCTCAG 1 -- us2k10--------
    rs1142506321,2
    F--110299099(+) CATCAA/GTTTAT 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs171112071,2
    C,F,H--110299117(+) TATTTA/GTTAGA 1 -- us2k118Minor allele frequency- G:0.06NA NS EA CSA WA 1962
    rs1853227421,2
    --110299203(+) GTGTAC/TGAATA 1 -- us2k10--------
    rs37820531,2
    C,F,H--110299371(+) AAAAAA/CAAAAG 1 -- us2k18Minor allele frequency- C:0.41NS EA WA NA 816
    rs665254401,2
    C--110299371(-) CTTTTG/T/TT  
            
    TTTTT
    1 -- us2k11NA 2
    rs1905286921,2
    --110299431(+) CTGTGC/TCCTTC 1 -- us2k10--------
    rs37590181,2
    C,F,A,H--110299437(+) CCTTCG/ACAGCT 1 -- us2k118Minor allele frequency- A:0.17NS EA NA 2226
    rs735641211,2
    C--110299469(+) AACGAC/TTTGAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1489211511,2
    --110299506(+) TGCCAC/TTGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FDX1 (110300594 - 110335605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FDX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898391CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FDX1
    DNA2.0 Custom Variant and Variant Library Synthesis for FDX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103260    OMIM disorders: --

    4 diseases for FDX1:    
    About MalaCards
    vitamin d-dependent rickets type i    congenital adrenal insufficiency    lipoid adrenal hyperplasia    cerebrotendinous xanthomatosis

    3 diseases from the University of Copenhagen DISEASES database for FDX1:
    Cerebrotendinous xanthomatosis     Congenital adrenal insufficiency     Proliferative diabetic retinopathy

    Find genes that share disorders with FDX1           About GenesLikeMe

    2 Novoseek inferred disease relationships for FDX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xanthomatosis cerebrotendinous 68.9 1 8950197 (1)
    choriocarcinoma 32.4 1 1316854 (1)

    Genetic Association Database (GAD): FDX1
    Human Genome Epidemiology (HuGE) Navigator: FDX1 (4 documents)

    Export disorders for FDX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FDX1 gene, integrated from 10 sources (see all 168):
    (articles sorted by number of sources associating them with FDX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of human placental ferredoxin. (PubMed id 2969697)1, 2, 3 Mittal S.... Vickery L.E. (Arch. Biochem. Biophys. 1988)
    2. Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode. (PubMed id 12699818)1, 2, 9 Johnson D.... Martin L.L. (Bioelectrochemistry 2003)
    3. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. (PubMed id 21636783)1, 2 Strushkevich N....Park H.W. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. (PubMed id 20547883)1, 2 Sheftel A.D.... Lill R. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    8. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. 1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins. (PubMed id 1909889)1, 2 Skjeldal L.... Vickery L.E. (Biochemistry 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2230 HGNC: 3638 AceView: FDX1 Ensembl:ENSG00000137714 euGenes: HUgn2230
    ECgene: FDX1 H-InvDB: FDX1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FDX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FDX1 gene:
    Search GeneIP for patents involving FDX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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