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FDX1 Gene(Protein Coding)

Ferredoxin 1

GCID:
GC11P110429
GIFtS:
58
Genes Participants
UDN Logo

Aliases for FDX1 Gene

Aliases for FDX1 Gene

  • Ferredoxin 1 2 3 5
  • Adrenal Ferredoxin 3 4
  • Hepatoredoxin 3 4
  • ADX 3 4
  • Adrenodoxin, Mitochondrial 3
  • Mitochondrial Adrenodoxin 3
  • Ferredoxin-1 4
  • Adrenodoxin 2
  • LOH11CR1D 3
  • FDX 3

External Ids for FDX1 Gene

Previous HGNC Symbols for FDX1 Gene

  • FDX

Previous GeneCards Identifiers for FDX1 Gene

  • GC11P112572
  • GC11P111771
  • GC11P110334
  • GC11P109838
  • GC11P109805
  • GC11P106225

Summaries for FDX1 Gene

Entrez Gene Summary for FDX1 Gene

  • This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDX1 Gene

FDX1 (Ferredoxin 1) is a Protein Coding gene. Diseases associated with FDX1 include Cerebrotendinous Xanthomatosis and Vitamin D-Dependent Rickets, Type I. Among its related pathways are Cytochrome P450 - arranged by substrate type and Diseases of metabolism. GO annotations related to this gene include iron ion binding and iron-sulfur cluster binding. An important paralog of this gene is FDX2.

UniProtKB/Swiss-Prot for FDX1 Gene

  • Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.

Gene Wiki entry for FDX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDX1 Gene

Genomics for FDX1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FDX1 Gene

Enhancers for FDX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G110372 1.5 FANTOM5 Ensembl ENCODE 23 -55.9 -55882 3.2 TBP PKNOX1 TBL1XR1 NFIB WRNIP1 GATA2 CBX5 FOS RELB ETV6 FDX1 LOC105369486 ZC3H12C RDX PIR61577
GH11G110378 1.1 FANTOM5 ENCODE 30.7 -49.3 -49349 3.9 CTCF PKNOX1 TAL1 MAX RAD21 YY1 ZNF316 NCOR1 SMC3 FOS FDX1 LOC105369486 RDX PIR61577
GH11G110427 1.4 Ensembl ENCODE 19.8 +1.8 1769 7.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 FDX1 ENSG00000271584 ENSG00000271390 GC11P110684
GH11G110376 1.1 Ensembl ENCODE 22.1 -52.6 -52572 2.0 PKNOX1 FOXA2 ARID4B SIN3A RAD21 RFX5 YY1 ZNF143 ZNF654 NFYC FDX1 LOC105369486 PIR61577
GH11G110347 1.5 FANTOM5 Ensembl ENCODE 15.9 -81.1 -81079 3.3 HDGF TBP PKNOX1 TBL1XR1 BMI1 RAD21 ZBTB40 EGR1 RELB ETV6 FDX1 RDX ZC3H12C LOC105369486
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FDX1 on UCSC Golden Path with GeneCards custom track

Promoters for FDX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044710 917 2401 HDGF ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 SP3 SP5

Transcription factor binding sites by QIAGEN in the FDX1 gene promoter:

Genomic Location for FDX1 Gene

Chromosome:
11
Start:
110,429,883 bp from pter
End:
110,464,884 bp from pter
Size:
35,002 bases
Orientation:
Plus strand

Genomic View for FDX1 Gene

Genes around FDX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDX1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FDX1 Gene

Proteins for FDX1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FDX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10109-ADX_HUMAN
    Recommended name:
    Adrenodoxin, mitochondrial
    Protein Accession:
    P10109
    Secondary Accessions:
    • B0YJ14
    • Q53YD6

    Protein attributes for FDX1 Gene

    Size:
    184 amino acids
    Molecular mass:
    19393 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • Interacts with CYP11A1.

    Three dimensional structures from OCA and Proteopedia for FDX1 Gene

neXtProt entry for FDX1 Gene

Protein Expression for FDX1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FDX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDX1 Gene

Domains & Families for FDX1 Gene

Protein Domains for FDX1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FDX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10109

UniProtKB/Swiss-Prot:

ADX_HUMAN :
  • Belongs to the adrenodoxin/putidaredoxin family.
Family:
  • Belongs to the adrenodoxin/putidaredoxin family.
genes like me logo Genes that share domains with FDX1: view

No data available for Gene Families for FDX1 Gene

Function for FDX1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FDX1 Gene

GENATLAS Biochemistry:
ferredoxin,ion sulfur electron transport protein for mitochondrial P450s
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Redox potential: E(0) is -448 mV.;
UniProtKB/Swiss-Prot Function:
Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.

Gene Ontology (GO) - Molecular Function for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding TAS 2969697
GO:0009055 electron carrier activity TAS,IDA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IDA 21636783
genes like me logo Genes that share ontologies with FDX1: view
genes like me logo Genes that share phenotypes with FDX1: view

Animal Models for FDX1 Gene

MGI Knock Outs for FDX1:
  • Fdx1 tm1b(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDX1 Gene

Localization for FDX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDX1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FDX1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,TAS --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FDX1: view

Pathways & Interactions for FDX1 Gene

genes like me logo Genes that share pathways with FDX1: view

Gene Ontology (GO) - Biological Process for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0008202 steroid metabolic process IEA --
GO:0008203 cholesterol metabolic process IEA,IDA 21636783
genes like me logo Genes that share ontologies with FDX1: view

No data available for SIGNOR curated interactions for FDX1 Gene

Drugs & Compounds for FDX1 Gene

Products:

  1. Drug

(19) Drugs for FDX1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitotane Approved Pharma Target, unknown 12

(19) Additional Compounds for FDX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FDX1: view

Transcripts for FDX1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FDX1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDX1 Gene

Ferredoxin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for FDX1 Gene

GeneLoc Exon Structure for
FDX1
ECgene alternative splicing isoforms for
FDX1

Expression for FDX1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FDX1 Gene

mRNA expression in normal human tissues for FDX1 Gene
mRNA expression by BioGPS for FDX1 GenemRNA expression by GTEx for FDX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FDX1 Gene

This gene is overexpressed in Adrenal Gland (x21.0).

Protein differential expression in normal tissues from HIPED for FDX1 Gene

This gene is overexpressed in Nasal epithelium (23.6), Adrenal (7.5), and Fetal testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FDX1 Gene



Protein tissue co-expression partners for FDX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FDX1 Gene:

FDX1

SOURCE GeneReport for Unigene cluster for FDX1 Gene:

Hs.744

mRNA Expression by UniProt/SwissProt for FDX1 Gene:

P10109-ADX_HUMAN
Tissue specificity: Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level).

Evidence on tissue expression from TISSUES for FDX1 Gene

  • Liver(4.5)
  • Lung(4.2)
  • Adrenal gland(3.9)
  • Nervous system(3.1)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with FDX1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FDX1 Gene

Orthologs for FDX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FDX1 34 35
  • 99.46 (n)
dog
(Canis familiaris)
 Mammalia FDX1 34 35
  • 84.18 (n)
rat
(Rattus norvegicus)
 Mammalia Fdx1 34
  • 77.9 (n)
cow
(Bos Taurus)
 Mammalia FDX1 34 35
  • 77.59 (n)
mouse
(Mus musculus)
 Mammalia Fdx1 34 16 35
  • 77.36 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia FDX1 35
  • 73 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia FDX1 35
  • 70 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FDX1 34 35
  • 76.25 (n)
lizard
(Anolis carolinensis)
 Reptilia FDX1 35
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fdx1 34
  • 72.18 (n)
Str.909 34
zebrafish
(Danio rerio)
 Actinopterygii fdx1 34 35
  • 69.05 (n)
Dr.13680 34
fruit fly
(Drosophila melanogaster)
 Insecta CG1319 34 35
  • 61.01 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003212 34
  • 52.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes YAH1 35
  • 32 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4213 35
  • 36 (a)
 OneToOne
Species where no ortholog for FDX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDX1 Gene

ENSEMBL:
Gene Tree for FDX1 (if available)
TreeFam:
Gene Tree for FDX1 (if available)

Paralogs for FDX1 Gene

Paralogs for FDX1 Gene

(1) SIMAP similar genes for FDX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FDX1 Gene

genes like me logo Genes that share paralogs with FDX1: view

Variants for FDX1 Gene

Sequence variations from dbSNP and Humsavar for FDX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000172871 -- 110,431,492(+) TAGTG(G/T)GTGCT intron-variant
rs1000207027 -- 110,441,830(+) TGTCT(C/T)CAGGG intron-variant
rs1000229516 -- 110,437,281(+) GAGCC(A/G)CCATG intron-variant
rs1000278190 -- 110,449,367(+) TTATT(A/G)TCTGT intron-variant
rs1000439221 -- 110,442,703(+) GACTT(C/T)GGACT intron-variant

Variation tolerance for FDX1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FDX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FDX1 Gene

Disorders for FDX1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FDX1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebrotendinous xanthomatosis
  • cholestanol storage disease
vitamin d-dependent rickets, type i
  • vitamin d-dependent rickets type i
adrenal insufficiency, congenital, with 46xy sex reversal, partial or complete
  • adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete
lipoid adrenal hyperplasia
  • lipoid congenital adrenal hyperplasia
congenital adrenal insufficiency
  • adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete
- elite association - COSMIC cancer census association via MalaCards
Search FDX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FDX1

Genetic Association Database (GAD)
FDX1
Human Genome Epidemiology (HuGE) Navigator
FDX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FDX1
genes like me logo Genes that share disorders with FDX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FDX1 Gene

Publications for FDX1 Gene

  1. Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode. (PMID: 12699818) Johnson D. … Martin L.L. (Bioelectrochemistry 2003) 3 4 22 64
  2. Molecular cloning and sequence analysis of human placental ferredoxin. (PMID: 2969697) Mittal S. … Vickery L.E. (Arch. Biochem. Biophys. 1988) 2 3 4 64
  3. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. (PMID: 21636783) Strushkevich N. … Park H.W. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X. … Bell D.A. (PLoS ONE 2010) 3 46 64

Products for FDX1 Gene

  • Addgene plasmids for FDX1

Sources for FDX1 Gene

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