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FDPS Gene

protein-coding   GIFtS: 69
GCID: GC01P155278

Farnesyl Diphosphate Synthase

  See FDPS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Farnesyl Diphosphate Synthase1 2 3     Farnesyl Pyrophosphate Synthase2
FPS2 3 5     Farnesyl Pyrophosphate Synthetase, Dimethylallyltranstransferase,
Geranyltranstransferase2
dimethylallyltranstransferase1 2     FPP Synthetase2
geranyltranstransferase1 2     Dimethylallyltranstransferase3
(2E,6E)-Farnesyl Diphosphate Synthase2 3     EC 2.5.1.13
FPP Synthase2 3     EC 2.5.1.103
Farnesyl Pyrophosphate Synthetase1     Geranyltranstransferase3
FPPS2     KIAA12933

External Ids:    HGNC: 36311   Entrez Gene: 22242   Ensembl: ENSG000001607527   OMIM: 1346295   UniProtKB: P143243   

Export aliases for FDPS gene to outside databases

Previous GC identifers: GC01P153136 GC01P151019 GC01P152056 GC01P152495 GC01P152091 GC01P153545 GC01P126640


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FDPS Gene:
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from
isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a
key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and
geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that
inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat
diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X.
Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Oct
2008)

GeneCards Summary for FDPS Gene:
FDPS (farnesyl diphosphate synthase) is a protein-coding gene. Diseases associated with FDPS include osteonecrosis of the jaw. GO annotations related to this gene include geranyltranstransferase activity and dimethylallyltranstransferase activity.

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324
Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a
precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and
ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the
sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl
pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FDPS gene promoter:
         SEF-1 (1)   NF-kappaB   NF-kappaB1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FDPS promoter sequence
   Search Chromatin IP Primers for FDPS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FDPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

FDPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDPS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155278:  view genomic region     (about GC identifiers)

Start:
155,278,539 bp from pter      End:
155,290,457 bp from pter
Size:
11,919 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324 (See protein sequence)
Recommended Name: Farnesyl pyrophosphate synthase  
Size: 419 amino acids; 48275 Da
Cofactor: Binds 3 magnesium ions per subunit
Subunit: Homodimer. Interacts with RSAD2. Interacts with HTLV-1 protein p13(II)
Sequence caution: Sequence=BAA03523.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for FDPS (see all 35):
1YQ7 (3D)        1YV5 (3D)        1ZW5 (3D)        2F7M (3D)        2F89 (3D)        2F8C (3D)    
Secondary accessions: D3DV91 E9PCI9 Q96G29
Alternative splicing: 2 isoforms:  P14324-1   P14324-2   

Explore the universe of human proteins at neXtProt for FDPS: NX_P14324

Explore proteomics data for FDPS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys80, Lys112, Lys123, Lys142, Lys187, Lys210, Lys332, Lys353, Lys359
  • Modification sites at PhosphoSitePlus

  • See FDPS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001129293.1  NP_001129294.1  NP_001229753.1  NP_001229754.1  NP_001995.1  

    ENSEMBL proteins: 
     ENSP00000357340   ENSP00000349078   ENSP00000391755  
    Reactome Protein details: P14324

    FDPS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FDPS
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FDPS
    GenScript Custom Purified and Recombinant Proteins Services for FDPS
    Novus Biologicals FDPS Proteins
    Novus Biologicals FDPS Lysates
    Sino Biological Recombinant Protein for FDPS
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FDPS

     
    Search eBioscience for Proteins for FDPS 

     
    antibodies-online proteins for FDPS (10 products) 

     
    antibodies-online peptides for FDPS

    FDPS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FDPS
    Browse R&D Systems for Antibodies
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    Novus Biologicals FDPS Antibodies
    Abcam antibodies for FDPS
    Cloud-Clone Corp. Antibodies for FDPS
    ThermoFisher Antibody for FDPS
    antibodies-online antibodies for FDPS (46 products) 

    FDPS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FDPS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FDPS
    Cloud-Clone Corp. CLIAs for FDPS
    Search eBioscience for ELISAs for FDPS 
    antibodies-online kits for FDPS (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: farnesyl diphosphate synthase
    Lanosterol biosynthesis pathway

    2 InterPro protein domains:
     IPR000092 Polyprenyl_synt
     IPR008949 Terpenoid_synth

    Graphical View of Domain Structure for InterPro Entry P14324

    ProtoNet protein and cluster: P14324

    1 Blocks protein domain: IPB000092 Polyprenyl synthetase

    UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324
    Similarity: Belongs to the FPP/GGPP synthase family


    Find genes that share domains with FDPS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPPS_HUMAN, P14324
    Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a
    precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and
    ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the
    sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl
    pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
    Catalytic activity: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
    Catalytic activity: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
    Enzyme regulation: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid
    rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to
    bud efficiently out of the cell

         Enzyme Numbers (IUBMB): EC 2.5.1.101 EC 2.5.1.11

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004161dimethylallyltranstransferase activity IEA--
    GO:0004337geranyltranstransferase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FDPS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FDPS:
     Increased viability after born 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FDPS

    miRNA
    Products:
        
    miRTarBase miRNAs that target FDPS:
    hsa-let-7e-5p (MIRT051567), hsa-mir-30c-2-3p (MIRT038702)

    Block miRNA regulation of human, mouse, rat FDPS using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FDPS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FDPS
    Predesigned siRNA for gene silencing in human, mouse, rat FDPS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FDPS

    Clone
    Products:
         
    OriGene clones in human, mouse for FDPS (see all 17)
    OriGene ORF clones in mouse, rat for FDPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FDPS (NM_002004)
    Sino Biological Human cDNA Clone for FDPS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDPS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FDPS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDPS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FPPS_HUMAN, P14324: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion3
    extracellular2
    peroxisome2
    chloroplast1
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FDPS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FDPS About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1superpathway of cholesterol biosynthesis
    superpathway of cholesterol biosynthesis0.85
    Terpenoid backbone biosynthesis0.34
    Cholesterol biosynthesis0.85
    superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)0.00
    Cholesterol biosynthesis0.62
    trans, trans-farnesyl diphosphate biosynthesis0.00
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    SREBP signalling0.31
    Activation of Gene Expression by SREBP (SREBF)0.75
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Influenza A
    Influenza A0.34
    5HTLV-I infection
    HTLV-I infection


    Find genes that share SuperPaths with FDPS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for FDPS
        Cholesterol biosynthesis
    SREBP signalling
    trans, trans-farnesyl diphosphate biosynthesis
    superpathway of cholesterol biosynthesis
    superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)


    2 Reactome Pathways for FDPS
        Cholesterol biosynthesis
    Activation of gene expression by SREBF (SREBP)

    1 PharmGKB Pathway for FDPS
        Bisphosphonate Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for FDPS):
        Terpenoid backbone biosynthesis
    Metabolic pathways
    Influenza A
    HTLV-I infection

    UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324
    Pathway: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate
    and isopentenyl diphosphate: step 1/1
    Pathway: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl
    diphosphate and isopentenyl diphosphate: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Array including FDPS: 

              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FDPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FDPS (P143242, 3 ENSP000003490784) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2858967 I2D: score=3 STRING: ENSP00000244769
    ADCK3Q8NI603, ENSP000003557394I2D: score=1 STRING: ENSP00000355739
    ATAD2Q6PL183, ENSP000002873944I2D: score=1 STRING: ENSP00000287394
    EIF4ENIF1Q9NRA83, ENSP000003281034I2D: score=1 STRING: ENSP00000328103
    HMGCRP040353, ENSP000002879364I2D: score=1 STRING: ENSP00000287936
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006695cholesterol biosynthetic process TAS--
    GO:0008299isoprenoid biosynthetic process ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0033384geranyl diphosphate biosynthetic process IEA--

    Find genes that share ontologies with FDPS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FDPS (FPPS)

    6 HMDB Compounds for FDPS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylallylpyrophosphate1,1-Dimethyl-4-phenylpiperazinium iodide (see all 24)358-72-5--
    Farnesyl pyrophosphate(2E,6E)-Farnesyl diphosphate (see all 15)13058-04-3--
    Geranyl-PPgeranyl-PP (see all 9)763-10-0--
    Isopentenyl pyrophosphate3-Methyl-3-butenyl pyrophosphate (see all 13)358-71-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Selected DrugBank Compounds for FDPS (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PamidronateAcide pamidronique [INN-French] (see all 5)40391-99-9targetinhibitor11160603 15487700 10620343 12177810 11752352 15713990
    RisedronateNE-58095 (see all 3)105462-24-6targetinhibitor11160603 10620343 16835450 11752352 16006204 18056045
    AlendronateAcide Alendronique [INN-French] (see all 5)66376-36-1targetinhibitor11160603 10620343 17535895 11752352
    IbandronateIbandronate sodium (see all 4)114084-78-5targetinhibitor11160603 16892359 11752352 16932286
    ZoledronateZOL (see all 2)118072-93-8targetinhibitor11160603 17477829 17535895 11752352
    Dimethylallyl Diphosphate-- 358-72-5target--10592235
    FARNESYL DIPHOSPHATE-- --target--10592235
    GERANYLGERANYL DIPHOSPHATE-- --target--10592235
    Geranyl Diphosphate-- --target--10592235
    ISOPENTENYL PYROPHOSPHATE-- --target--10592235

    Selected IUPHAR Ligands for FDPS (farnesyl diphosphate synthase) (see all 22)    About this table
    LigandTypeActionAffinityPubmed IDs
    zoledronate
    InhibitorInhibition10.1518327899
    minodronic acid
    InhibitorInhibition8.5220394422
    [[(3-methylpyridin-2-yl)amino]methyl]phosphonic acid
    InhibitorInhibition8.2118327899
    risedronate
    InhibitorInhibition811160603
    NE97220
    InhibitorInhibition7.9218327899
    [1-fluoro-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
    InhibitorInhibition7.7917975902
    NE58043
    InhibitorInhibition7.4918327899
    NE97221
    InhibitorInhibition7.4118327899
    diphosphoric acid
    InhibitorInhibition7.3918327899
    alendronic acid
    InhibitorInhibition7.311160603

    Selected Novoseek inferred chemical compound relationships for FDPS gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    farnesyl diphosphate 97.5 141 11785983 (5), 10620343 (5), 11160603 (5), 1429508 (3) (see all 79)
    isopentenyl diphosphate 87.7 8 11785983 (2), 11112517 (1), 10620343 (1), 8262934 (1) (see all 6)
    dimethylallyl diphosphate 83.9 5 11112517 (1), 14672944 (1), 17963374 (1), 7858223 (1)
    mevalonate 82.9 13 11785983 (2), 16179378 (2), 11577991 (1), 16932286 (1) (see all 10)
    squalene 75.5 7 19885625 (1), 11792726 (1), 19680554 (1), 8619637 (1) (see all 6)
    pamidronate 74.8 4 15487700 (1), 10620343 (1), 18442135 (1)
    zoledronic acid 72.8 3 11160603 (1), 18494934 (1)
    risedronate 71.4 1 10620343 (1)
    sterol 70.4 8 9430668 (1), 15473864 (1), 19680554 (1), 8864955 (1) (see all 6)
    alendronate 65.3 6 10620343 (4), 11785983 (1)

    4 PharmGKB related drug/compound annotations for FDPS gene    About this table
    Drug/compound PharmGKB Annotation
    BisphosphonatesCA  
    alendronateCA  
    risedronateCA  
    zoledronateCA  



    Find genes that share compounds with FDPS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FDPS gene (5 alternative transcripts): 
    NM_001135821.1  NM_001135822.1  NM_001242824.1  NM_001242825.1  NM_002004.3  

    Unigene Cluster for FDPS:

    Farnesyl diphosphate synthase
    Hs.335918  [show with all ESTs]
    Unigene Representative Sequence: BM542682
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000468479 ENST00000461507 ENST00000467076 ENST00000368356(uc001fkc.2)
    ENST00000474345 ENST00000471117 ENST00000495308 ENST00000487002 ENST00000491013
    ENST00000356657(uc001fke.2) ENST00000465559 ENST00000470171 ENST00000489003
    ENST00000477057 ENST00000492887 ENST00000492244 ENST00000490140 ENST00000489324

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FDPS
    Clone
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    OriGene clones in human, mouse for FDPS (see all 17)
    OriGene ORF clones in mouse, rat for FDPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FDPS (NM_002004)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDPS
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FDPS
      QuantiTect SYBR Green Assays in human, mouse, rat FDPS
      QuantiFast Probe-based Assays in human, mouse, rat FDPS

    Additional mRNA sequence: 

    AK291084.1 BC010004.2 D14697.1 J05262.1 M29863.1 

    Selected DOTS entries (see all 59):

    DT.100712134  DT.40235399  DT.100639599  DT.95133952  DT.85104788  DT.92468004  DT.100701015  DT.92467985 
    DT.92468021  DT.92467976  DT.100701014  DT.92468010  DT.100800090  DT.101985274  DT.95302259  DT.97862674 
    DT.121365043  DT.121365136  DT.100700983  DT.121365069  DT.121365163  DT.95144374  DT.100039672  DT.95146655 

    Selected AceView cDNA sequences (see all 785):

    BG387755 BU553603 BE743399 BU174823 BM464746 CB129640 BU149669 BQ430140 
    CB128814 BU629384 BU168409 CA428103 BG697322 CA417637 BG696284 BQ431665 
    BQ066601 BU521077 BQ679165 BQ682430 BE741495 BU174696 BE741165 BU502711 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FDPS (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
    SP1:                                                  -     -     -     -     -     -     -                 -           -     -     -                           
    SP2:                                                  -     -     -     -     -     -                       -           -     -     -                           
    SP3:                                                  -     -     -     -     -     -     -     -     -     -           -     -     -                           
    SP4:                                                  -     -     -     -                                   -           -     -     -                           
    SP5:                                                                    -     -     -                       -           -     -     -                           

    ExUns: 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:                    -                                       
    SP2:                    -                                       
    SP3:                    -                                       
    SP4:                    -                                       
    SP5:                    -                                       


    ECgene alternative splicing isoforms for FDPS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FDPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGAATTG
    FDPS Expression
    About this image


    FDPS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    FDPS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FDPS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335918
        Pathway & Disease-focused RT2 Profiler PCR Array including FDPS: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDPS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FDPS gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fdps1 , 5 farnesyl diphosphate synthetase1, 5 85.6(n)1
    83.77(a)1
      3 (39.01 cM)5
    1101961  NM_001253751.11  NP_001240680.11 
     890935925 
    chicken
    (Gallus gallus)
    Aves FDPS1 farnesyl diphosphate synthase (farnesyl pyrophosphate more 71.72(n)
    69.7(a)
      425061  XM_422855.4  XP_422855.3 
    lizard
    (Anolis carolinensis)
    Reptilia FDPS6
    farnesyl diphosphate synthase
    26(a)
    1 ↔ 1
    GL343519.1(250386-280030)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252572 Xenopus laevis transcribed sequence with moderate similarity more 77.2(n)    BJ058210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fdps1 farnesyl diphosphate synthase (farnesyl pyrophosphate more 62.49(n)
    63.25(a)
      552997  NM_001025471.1  NP_001020642.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fpps1 , 3 geranyltranstransferase3
    Farnesyl pyrophosphate synthase1
    46(a)3
    54.47(n)1
    46.9(a)1
      47F13
    362091  NM_058032.41  NP_477380.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R06C1.23 Polyprenyl synthetases 35(a)   I(11926080-11931962)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG20(YJL167W)4
    ERG201
    Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase more4
    ERG201
    52.66(n)1
    46.45(a)1
      10(105014-106072)4
    8532721, 4  NP_012368.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FPS21 FPS2 52.82(n)
    48.07(a)
      827430  NM_117823.3  NP_193452.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05434001 Os05g0543400 52.89(n)
    47.9(a)
      4339489  NM_001062739.1  NP_001056204.1 


    ENSEMBL Gene Tree for FDPS (if available)
    TreeFam Gene Tree for FDPS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FDPS gene

    Find genes that share paralogs with FDPS           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for FDPS (see all 9)
    PGOHUM00000247804 PGOHUM00000246763 PGOHUM00000246765 PGOHUM00000247198 PGOHUM00000244411


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FDPS (see all 225)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827070531,2
    --155276649(+) CTTCTA/GGTGGG 4 -- us2k10--------
    rs1868437491,2
    --155276705(+) TGAGTA/GTTACA 5 -- us2k10--------
    rs2009139091,2
    C--155276939(+) ACCTC-/AGGTGAT 5 -- us2k10--------
    rs1446650991,2
    C--155276946(+) TGATCC/TGCCCA 5 -- us2k10--------
    rs1913268801,2
    --155276991(+) GAGCCA/CCTGCA 5 -- us2k10--------
    rs1485095451,2
    --155277004(+) CAGCCA/GTGTTT 5 -- us2k10--------
    rs1180056231,2
    C,F--155277078(+) ATACAC/TGGAAT 5 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1117754481,2
    C,F--155277180(+) ACTGGG/ATAGAA 5 -- us2k11Minor allele frequency- A:0.50WA 2
    rs780031151,2
    C,F--155277204(+) TACTGG/AACTGC 5 -- us2k11Minor allele frequency- A:0.15NA 120
    rs1121845081,2
    C,F--155277278(+) GTCATG/AAAGAC 5 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for FDPS (155278539 - 155290457 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FDPS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3032CNV Insertion18451855
    dgv3n68CNV Loss17160897
    nsv872457CNV Loss21882294
    nsv831636CNV Loss17160897
    esv33869CNV Loss17666407
    dgv132e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FDPS
    DNA2.0 Custom Variant and Variant Library Synthesis for FDPS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134629    OMIM disorders: --

    1 disease for FDPS:    
    About MalaCards
    osteonecrosis of the jaw

    3 diseases from the University of Copenhagen DISEASES database for FDPS:
    Disseminated intravascular coagulation     Osteoporosis     Chagas disease

    Find genes that share disorders with FDPS           About GenesLikeMe

    7 Novoseek inferred disease relationships for FDPS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis 52 1 17905588 (1)
    monocytic leukemia 51.7 1 1968462 (1)
    bone diseases 31 1 17905588 (1)
    response acute phase 26.4 2 17062705 (1), 16650801 (1)
    cancer 5.95 2 14680449 (1)
    metastasis 0 1 14680449 (1)
    tumors 0 2 15459425 (1), 18454049 (1)

    Genetic Association Database (GAD): FDPS
    Human Genome Epidemiology (HuGE) Navigator: FDPS (7 documents)

    Export disorders for FDPS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FDPS gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with FDPS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3- hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester. (PubMed id 1968462)1, 2, 3, 9 Wilkin D.J.... Edwards P.A. (J. Biol. Chem. 1990)
    2. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. (PubMed id 11160603)1, 7, 9 Dunford J.E....Rogers M.J. (J. Pharmacol. Exp. Ther. 2001)
    3. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. (PubMed id 10620343)1, 7, 9 Bergstrom J.D....Rodan G. (Arch. Biochem. Biophys. 2000)
    4. Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. (PubMed id 15713990)1, 7, 9 Notarnicola M....Caruso M.G. (Oncology 2004)
    5. Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. (PubMed id 11773414)1, 2, 9 Lefebvre L.... Willems L. (J. Virol. 2002)
    6. Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis. (PubMed id 18687167)1, 4, 9 Marini F....Brandi M.L. (Curr Med Res Opin 2008)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    9. Association study of cholesterol-related genes in Alzheimer's disease. (PubMed id 17387528)1, 4 Wollmer M.A....Papassotiropoulos A. (Neurogenetics 2007)
    10. Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. (PubMed id 16892359)2, 7 Rondeau J.-M....Jahnke W. (ChemMedChem 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2224 HGNC: 3631 AceView: FDPS Ensembl:ENSG00000160752 euGenes: HUgn2224
    ECgene: FDPS Kegg: 2224 H-InvDB: FDPS

    (According to HUGE)
    About This Section

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    HUGE: KIAA1293

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FDPS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FDPS gene:
    Search GeneIP for patents involving FDPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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