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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FDPS Gene

protein-coding GIFtS: 65
GCID: GC01P155278

farnesyl diphosphate synthase

Explore 25 diseases affiliated with
FDPS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Farnesyl Diphosphate Synthase¹ ² ³		FPP Synthetase²
FPS² ³ ⁵		Geranyltranstransferase³
(2E,6E)-Farnesyl Diphosphate Synthase² ³		Dimethylallyltranstransferase³
FPP Synthase² ³		EC 2.5.1.1³
FPPS²		EC 2.5.1.10³
Dimethylallyltranstransferase³		Geranyltranstransferase³
Farnesyl Pyrophosphate Synthase²		KIAA1293³
Farnesyl Pyrophosphate Synthetase, Dimethylallyltranstransferase, Geranyltranstransferase²

External Ids:	HGNC: 3631¹	Entrez Gene: 2224²	Ensembl: ENSG00000160752⁷	OMIM: 134629⁵	UniProtKB: P14324³

Export aliases for FDPS gene to outside databases

Previous GC identifers: GC01P153136 GC01P151019 GC01P152056 GC01P152495 GC01P152091 GC01P153545 GC01P126640

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FDPS:

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from

isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key

intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation,

and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the

post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption.

Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding

different isoforms have been found for this gene.(provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a

precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP

also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of

isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant

geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FDPS gene promoter:
SEF-1 (1) NF-kappaB NF-kappaB1 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FDPS promoter sequence

Search SABiosciences Chromatin IP Primers for FDPS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDPS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22

FDPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FDPS gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P155278: view genomic region (about GC identifiers)

Start:	155,278,539 bp from pter	End:	155,290,457 bp from pter
Size:	11,919 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324 (See protein sequence)

Recommended Name: Farnesyl pyrophosphate synthase

Size: 419 amino acids; 48275 Da

Cofactor: Binds 3 magnesium ions per subunit

Subunit: Homodimer. Interacts with RSAD2. Interacts with HTLV-1 protein p13(II)

Subcellular location: Cytoplasm

Caution: It is uncertain whether Met-1 or Met-67 is the initiator

Sequence caution: Sequence=AAA52423.1; Type=Erroneous initiation; Sequence=BAA03523.2; Type=Erroneous initiation;

6/32 PDB 3D structures from and Proteopedia for FDPS (see all 32):

1YQ7 (3D)

1YV5 (3D)

1ZW5 (3D)

2F7M (3D)

2F89 (3D)

2F8C (3D)

Secondary accessions: D3DV91 Q96G29

Explore the universe of human proteins at neXtProt for FDPS: NX_P14324

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14324

FDPS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001129293.1 NP_001129294.1 NP_001229753.1 NP_001229754.1 NP_001995.1

ENSEMBL proteins:

ENSP00000357340 ENSP00000349078 ENSP00000391755

Reactome Protein details: P14324
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): FDPS OriGene Custom Protein Services for FDPS
	GenScript Custom Purified and Recombinant Proteins Services for FDPS
	Novus Biologicals FDPS Proteins Novus Biologicals FDPS Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FDPS

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--

FDPS for ontologies About GeneDecksing

FDPS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FDPS
	Browse R&D Systems for Antibodies
	OriGene Antibodies: FDPS OriGene Custom Antibody Services for FDPS
	GenScript Custom Superior Antibodies Services for FDPS
	Novus Biologicals FDPS Antibodies
	Abcam antibodies for FDPS
	Uscn Antibodies for FDPS
	ThermoFisher Antibodies for FDPS

Assay Products for FDPS:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FDPS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FDPS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FDPS for domains About GeneDecksing

2 InterPro domains/families:

IPR000092 Polyprenyl_synt

IPR008949 Terpenoid_synth

Graphical View of Domain Structure for InterPro Entry P14324

ProtoNet protein and cluster: P14324

1 Blocks protein family: IPB000092 Polyprenyl synthetase

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Similarity: Belongs to the FPP/GGPP synthase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a

precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP

also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of

isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant

geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

Catalytic activity: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate

Catalytic activity: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate

Enzyme regulation: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts

at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud

efficiently out of the cell

Enzyme Numbers (IUBMB): EC 2.5.1.10¹ EC 2.5.1.1¹

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FDPS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDPS
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FDPS
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FDPS (see all 6) OriGene siRNA: FDPS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDPS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FDPS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDPS (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDPS (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FDPS (NM_002004)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDPS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDPS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FDPS
		Search LifeMap BioReagents cell lines for FDPS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FDPS

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004161	dimethylallyltranstransferase activity	IEA	--
GO:0004337	geranyltranstransferase activity	IEA	--
GO:0016740	transferase activity	--	--
GO:0046872	metal ion binding	IEA	--

FDPS for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FDPS:

Increased viability after born

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	1.00			SREBP signalling	0.46
	Activation of Gene Expression by SREBP (SREBF)	0.67

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Cholesterol biosynthesis

	Cholesterol biosynthesis	1.00			Cholesterol Biosynthesis	0.68
	superpathway of cholesterol biosynthesis	0.81

superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)

superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)

1.00

Terpenoid backbone biosynthesis

0.71

Bisphosphonate Pathway, Pharmacodynamics

Bisphosphonate Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 BioSystems Pathways for FDPS

	Cholesterol Biosynthesis
	SREBP signalling
	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	superpathway of cholesterol biosynthesis
	trans, trans-farnesyl diphosphate biosynthesis

5/6 Reactome Pathways for FDPS (see all 6)

	Metabolism
	Cholesterol biosynthesis
	Expression of Farnesyl Diphosphate Synthase (FDPS)
	Activation of Gene Expression by SREBP (SREBF)
	Metabolism of lipids and lipoproteins

1 PharmGKB Pathway for FDPS

Bisphosphonate Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for FDPS):

	Terpenoid backbone biosynthesis
	Metabolic pathways
	Influenza A

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Pathway: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and

isopentenyl diphosphate: step 1/1

Pathway: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate

and isopentenyl diphosphate: step 1/1

FDPS for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FDPS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/102 Interacting proteins for FDPS (P14324^{2, 3} ENSP00000349078⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 102)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²^,³, ENSP00000244769⁴	MINT-2858967 I2D: score=3 STRING: ENSP00000244769
ADCK3	Q8NI60³, ENSP00000355739⁴	I2D: score=1 STRING: ENSP00000355739
ATAD2	Q6PL18³, ENSP00000287394⁴	I2D: score=1 STRING: ENSP00000287394
EIF4ENIF1	Q9NRA8³, ENSP00000328103⁴	I2D: score=1 STRING: ENSP00000328103
FA2H	Q7L5A8³, ENSP00000219368⁴	I2D: score=1 STRING: ENSP00000219368

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006695	cholesterol biosynthetic process	TAS	--
GO:0008299	isoprenoid biosynthetic process	--	--
GO:0019048	virus-host interaction	IEA	--
GO:0033384	geranyl diphosphate biosynthetic process	IEA	--
GO:0044281	small molecule metabolic process	TAS	--

FDPS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FDPS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for FDPS available from Tocris Bioscience About this table

Compound	Action	CAS #
Risedronate	Farnesyl diphosphate (FPP) synthase inhibitor	[115436-72-1]
MK 217	Inhibitor of farnesyl diphosphate synthase (FPPS)	[121268-17-5]

6 HMDB Compounds for FDPS About this table

Compound	Synonyms	CAS #	PubMed Ids
Dimethylallylpyrophosphate	1,1-Dimethyl-4-phenylpiperazinium iodide (see all 24)	358-72-5	--
Farnesyl pyrophosphate	(2E,6E)-Farnesyl diphosphate (see all 15)	13058-04-3	--
Geranyl-PP	geranyl-PP (see all 9)	763-10-0	--
Isopentenyl pyrophosphate	3-Methyl-3-butenyl pyrophosphate (see all 13)	358-71-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

10/11 DrugBank Compounds for FDPS (see all 11) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pamidronate	Acide pamidronique [INN-French] (see all 5)	40391-99-9	target	inhibitor	11160603 15487700 10620343 12177810 11752352 15713990
Risedronate	NE-58095 (see all 3)	105462-24-6	target	inhibitor	11160603 10620343 16835450 11752352 16006204 18056045
Alendronate	Acide Alendronique [INN-French] (see all 5)	66376-36-1	target	inhibitor	11160603 10620343 17535895 11752352
Ibandronate	Ibandronate sodium (see all 4)	114084-78-5	target	inhibitor	11160603 16892359 11752352 16932286
Zoledronate	ZOL (see all 2)	118072-93-8	target	inhibitor	11160603 17477829 17535895 11752352
Dimethylallyl Diphosphate	--	358-72-5	target	--	10592235
FARNESYL DIPHOSPHATE	--	--	target	--	10592235
GERANYLGERANYL DIPHOSPHATE	--	--	target	--	10592235
Geranyl Diphosphate	--	--	target	--	10592235
ISOPENTENYL PYROPHOSPHATE	--	--	target	--	10592235

10/17 Novoseek chemical compound relationships for FDPS gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
farnesyl diphosphate	97.5	141	11785983 (5), 10620343 (5), 11160603 (5), 1429508 (3) (see all 79)
isopentenyl diphosphate	87.7	8	11785983 (2), 11112517 (1), 10620343 (1), 8262934 (1) (see all 6)
dimethylallyl diphosphate	83.9	5	11112517 (1), 14672944 (1), 17963374 (1), 7858223 (1)
mevalonate	82.9	13	11785983 (2), 16179378 (2), 11577991 (1), 16932286 (1) (see all 10)
squalene	75.5	7	19885625 (1), 11792726 (1), 19680554 (1), 8619637 (1) (see all 6)
pamidronate	74.8	4	15487700 (1), 10620343 (1), 18442135 (1)
zoledronic acid	72.8	3	11160603 (1), 18494934 (1)
risedronate	71.4	1	10620343 (1)
sterol	70.4	8	9430668 (1), 15473864 (1), 19680554 (1), 8864955 (1) (see all 6)
alendronate	65.3	6	10620343 (4), 11785983 (1)

3 PharmGKB related drug/compound annotations for FDPS gene

Drug/compound	PharmGKB Annotation
Bisphosphonates	CA
alendronate	CA
risedronate	CA

About this table

Search CenterWatch for drugs/clinical trials and news about FDPS / FPPS

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FDPS gene (5 alternative transcripts):

NM_001135821.1 NM_001135822.1 NM_001242824.1 NM_001242825.1 NM_002004.3

Unigene Cluster for FDPS:

Farnesyl diphosphate synthase

Hs.335918 [show with all ESTs]

Unigene Representative Sequence: BM542682

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000468479 ENST00000461507 ENST00000467076 ENST00000368356(uc001fkc.2)

ENST00000474345 ENST00000471117 ENST00000495308 ENST00000487002 ENST00000491013

ENST00000356657(uc001fke.2) ENST00000465559 ENST00000470171 ENST00000489003

ENST00000477057 ENST00000492887 ENST00000492244 ENST00000490140 ENST00000489324

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FDPS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FDPS
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FDPS
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FDPS (see all 6) OriGene siRNA: FDPS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDPS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDPS (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDPS (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FDPS (NM_002004)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FDPS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDPS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FDPS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FDPS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDPS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDPS

Additional cDNA sequence:

AK291084.1 BC010004.2 D14697.1 J05262.1 M29863.1

24/59 DOTS entries (see all 59):

DT.100712134 DT.40235399 DT.100639599 DT.95133952 DT.85104788 DT.92468004 DT.100701015 DT.92467985

DT.92468021 DT.92467976 DT.100701014 DT.92468010 DT.100800090 DT.101985274 DT.95302259 DT.97862674

DT.121365043 DT.121365136 DT.100700983 DT.121365069 DT.121365163 DT.95144374 DT.100039672 DT.95146655

24/785 AceView cDNA sequences (see all 785):

BG697322 BE884479 CB154126 CB144686 CB110271 CR599124 BQ686242 CR596980

BX366034 BQ924875 BF794626 BI257971 BG473101 BI092666 BE790907 BG675254

BQ650947 BG697666 CB145549 CB159101 BQ894303 BQ065158 BU686382 BP340053

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for FDPS (see all 23) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·
SP1:																	-		-		-		-		-		-		-						-				-		-		-
SP2:																	-		-		-		-		-		-								-				-		-		-
SP3:																	-		-		-		-		-		-		-		-		-		-				-		-		-
SP4:																	-		-		-		-												-				-		-		-
SP5:																							-		-		-								-				-		-		-

ExUns:	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b
SP1:							-
SP2:							-
SP3:							-
SP4:							-
SP5:							-

ECgene alternative splicing isoforms for FDPS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FDPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGAATTG

About this image

FDPS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Eye

Gut Tube

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

See FDPS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FDPS

SOURCE GeneReport for Unigene cluster: Hs.335918

SABiosciences Expression via Pathway-Focused PCR Array including FDPS:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FDPS gene from 9/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fdps^{1 , 5}	farnesyl diphosphate synthetase^{1, 5}	85.6(n)¹ 83.77(a)¹		3 (39.01 cM)⁵ 110196¹ NM_001253751.1¹ NP_001240680.1¹ 89093592⁵
chicken (Gallus gallus)	Aves	FDPS¹	farnesyl diphosphate synthase (farnesyl pyrophosphate more	71.72(n) 69.7(a)		425061 XM_422855.3 XP_422855.3
African clawed frog (Xenopus laevis)	Amphibia	Xl.25257²	Xenopus laevis transcribed sequence with moderate similarity more	77.2(n)		BJ058210.1
zebrafish (Danio rerio)	Actinopterygii	fdps¹	farnesyl diphosphate synthase (farnesyl pyrophosphate more	62.49(n) 63.25(a)		552997 NM_001025471.1 NP_001020642.1
fruit fly (Drosophila melanogaster)	Insecta	Fpps^{1 , 3}	geranyltranstransferase³ Farnesyl pyrophosphate synthase¹	46(a)³ 54.47(n)¹ 46.9(a)¹		47F1³ 36209¹ NM_058032.4¹ NP_477380.1¹
worm (Caenorhabditis elegans)	Secernentea	R06C1.2³	Polyprenyl synthetases	35(a)		I(11926080-11931962) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ERG20(YJL167W)⁴ ERG20¹	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase more⁴ Erg20p¹	51.86(n)¹ 45.59(a)¹		10(105014-106072)⁴ 853272^{1, 4} NP_012368.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	FPS2⁶ FPS1⁶	farnesyl diphosphate synthase 1	47(a) 43(a)	many → 1 many → 1	4(9648527-9650912) 5(19345173-19347629)
rice (Oryza sativa)	Liliopsida	Os04g0657100¹	hypothetical protein	50.74(n) 43.06(a)		4337260 NM_001060656.1 NP_001054121.1

ENSEMBL Gene Tree for FDPS (if available)
TreeFam Gene Tree for FDPS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FDPS gene

FDPS for paralogs About GeneDecksing

5/9 Pseudogenes.org Pseudogenes for FDPS (see all 9)
PGOHUM00000247804 PGOHUM00000246763 PGOHUM00000246765 PGOHUM00000247198 PGOHUM00000244411

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182707053^1,2		--	155276649(+)	`CTTCTA/GGTGGG`	4	--	us2k¹		0	--	--	--	--
rs186843749^1,2		--	155276705(+)	`TGAGTA/GTTACA`	5	--	us2k¹		0	--	--	--	--
rs200913909^1,2		--	155276939(+)	`ACCTC-/AGGTGAT`	5	--	us2k¹		0	--	--	--	--
rs144665099^1,2		--	155276946(+)	`TGATCC/TGCCCA`	5	--	us2k¹		0	--	--	--	--
rs191326880^1,2		--	155276991(+)	`GAGCCA/CCTGCA`	5	--	us2k¹		0	--	--	--	--
rs148509545^1,2		--	155277004(+)	`CAGCCA/GTGTTT`	5	--	us2k¹		0	--	--	--	--
rs118005623^1,2	F,	--	155277078(+)	`ATACAC/TGGAAT`	5	--	us2k¹		1		EA	120
rs111775448^1,2	C,	--	155277180(+)	`ACTGGG/ATAGAA`	5	--	us2k¹		1		WA	2
rs78003115^1,2	F,	--	155277204(+)	`TACTGG/AACTGC`	5	--	us2k¹		1		NA	120
rs112184508^1,2	C,	--	155277278(+)	`GTCATG/AAAGAC`	5	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for FDPS (155278539 - 155290457 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FDPS
2 CNVs: 3315 6789

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FDPS for disorders           About GeneDecksing

OMIM gene information: 134629    OMIM disorders: --

20/25 diseases for FDPS (see all 25):    About MalaCards

disseminated intravascular coagulation human t-cell leukemia virus type 1 cholesterol monocytic leukemia

heart aneurysm follicular lymphoma osteoporosis t-cell leukemia

hepatoblastoma leukemia pheochromocytoma hepatocellular carcinoma

alzheimer's disease influenza colorectal cancer osteosarcoma

prostate cancer breast cancer glioblastoma ataxia

2 diseases from the University of Copenhagen DISEASES database for FDPS:

Disseminated intravascular coagulation Heart aneurysm

7 Novoseek disease relationships for FDPS gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoporosis	52	1	17905588 (1)
monocytic leukemia	51.7	1	1968462 (1)
bone diseases	31	1	17905588 (1)
response acute phase	26.4	2	17062705 (1), 16650801 (1)
cancer	5.95	2	14680449 (1)
metastasis	0	1	14680449 (1)
tumors	0	2	15459425 (1), 18454049 (1)

Human Genome Epidemiology (HuGE) Navigator: FDPS (7 documents)

Export disorders for FDPS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FDPS gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with FDPS)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3- hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester. (PubMed id 1968462)^{1, 2, 3, 9} Wilkin D.J.... Edwards P.A. (1990)
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. (PubMed id 11160603)^{1, 7, 9} Dunford J.E....Rogers M.J. (2001)
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. (PubMed id 10620343)^{1, 7, 9} Bergstrom J.D....Rodan G. (2000)
Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. (PubMed id 15713990)^{1, 7, 9} Notarnicola M....Caruso M.G. (2004)
Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. (PubMed id 11773414)^{1, 2, 9} Lefebvre L.... Willems L. (2002)
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. (PubMed id 16892359)^{2, 7} Rondeau J.-M....Jahnke W. (2006)
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. (PubMed id 16684881)^{1, 2} Kavanagh K.L.... Oppermann U. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{1, 2} Nomura N.... Tabata S. (1994)
Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells. (PubMed id 2690933)^{1, 2} Sheares B.T.... Karkas J.D. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2224	HGNC: 3631	AceView: FDPS	Ensembl:ENSG00000160752	euGenes: HUgn2224
ECgene: FDPS	Kegg: 2224	H-InvDB: FDPS

(According to HUGE)
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HUGE: KIAA1293

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FDPS	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FDPS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FDPS gene:
Search GeneIP for patents involving FDPS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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farnesyl diphosphate synthase

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