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Aliases for FDPS Gene

Aliases for FDPS Gene

  • Farnesyl Diphosphate Synthase 2 3 4
  • Dimethylallyltranstransferase 2 3 4
  • Geranyltranstransferase 2 3 4
  • (2E,6E)-Farnesyl Diphosphate Synthase 3 4
  • FPP Synthase 3 4
  • FPS 3 4
  • Farnesyl Pyrophosphate Synthetase, Dimethylallyltranstransferase, Geranyltranstransferase 3
  • Farnesyl Pyrophosphate Synthetase 2
  • FPP Synthetase 3
  • EC 2.5.1.10 4
  • EC 2.5.1.1 4
  • KIAA1293 4
  • FPPS 3

External Ids for FDPS Gene

Previous GeneCards Identifiers for FDPS Gene

  • GC01P153136
  • GC01P151019
  • GC01P152056
  • GC01P152495
  • GC01P152091
  • GC01P153545
  • GC01P126640

Summaries for FDPS Gene

Entrez Gene Summary for FDPS Gene

  • This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

GeneCards Summary for FDPS Gene

FDPS (Farnesyl Diphosphate Synthase) is a Protein Coding gene. Diseases associated with FDPS include osteonecrosis of the jaw and prothrombin deficiency. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include poly(A) RNA binding and geranyltranstransferase activity.

UniProtKB/Swiss-Prot for FDPS Gene

  • Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDPS Gene

Genomics for FDPS Gene

Regulatory Elements for FDPS Gene

Genomic Location for FDPS Gene

Chromosome:
1
Start:
155,308,748 bp from pter
End:
155,320,666 bp from pter
Size:
11,919 bases
Orientation:
Plus strand

Genomic View for FDPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FDPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDPS Gene

Proteins for FDPS Gene

  • Protein details for FDPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14324-FPPS_HUMAN
    Recommended name:
    Farnesyl pyrophosphate synthase
    Protein Accession:
    P14324
    Secondary Accessions:
    • D3DV91
    • E9PCI9
    • Q96G29

    Protein attributes for FDPS Gene

    Size:
    419 amino acids
    Molecular mass:
    48275 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 3 Mg(2+) ions per subunit.;
    Quaternary structure:
    • Homodimer. Interacts with RSAD2. Interacts with HTLV-1 protein p13(II).
    SequenceCaution:
    • Sequence=BAA03523.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FDPS Gene

    Alternative splice isoforms for FDPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FDPS Gene

Proteomics data for FDPS Gene at MOPED

Post-translational modifications for FDPS Gene

  • Ubiquitination at Lys 112, Lys 142, Lys 187, Lys 210, Lys 332, Lys 353, and Lys 359
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FDPS

No data available for DME Specific Peptides for FDPS Gene

Domains & Families for FDPS Gene

Gene Families for FDPS Gene

Protein Domains for FDPS Gene

Suggested Antigen Peptide Sequences for FDPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14324

UniProtKB/Swiss-Prot:

FPPS_HUMAN :
  • Belongs to the FPP/GGPP synthase family.
Family:
  • Belongs to the FPP/GGPP synthase family.
genes like me logo Genes that share domains with FDPS: view

Function for FDPS Gene

Molecular function for FDPS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.
UniProtKB/Swiss-Prot Function:
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

Enzyme Numbers (IUBMB) for FDPS Gene

Gene Ontology (GO) - Molecular Function for FDPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004161 dimethylallyltranstransferase activity IBA --
GO:0004337 geranyltranstransferase activity IBA --
GO:0016740 transferase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FDPS: view
genes like me logo Genes that share phenotypes with FDPS: view

Animal Model Products

miRNA for FDPS Gene

miRTarBase miRNAs that target FDPS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDPS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FDPS Gene

Localization for FDPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDPS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FDPS Gene COMPARTMENTS Subcellular localization image for FDPS gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
peroxisome 2
chloroplast 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FDPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FDPS: view

Pathways & Interactions for FDPS Gene

genes like me logo Genes that share pathways with FDPS: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

UniProtKB/Swiss-Prot P14324-FPPS_HUMAN

  • Pathway: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1
  • Pathway: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1

Gene Ontology (GO) - Biological Process for FDPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0008299 isoprenoid biosynthetic process --
GO:0016032 viral process IEA --
GO:0033384 geranyl diphosphate biosynthetic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FDPS: view

No data available for SIGNOR curated interactions for FDPS Gene

Drugs & Compounds for FDPS Gene

(43) Drugs for FDPS Gene - From: IUPHAR, DGIdb, NovoSeek, ApexBio, DrugBank, HMDB, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zoledronate Approved Pharma Inhibition, Inhibitor, inhibitor, Target Osteoclast function modifiers (important in bone metastasis) 0
Alendronate Approved Pharma Inhibition, Inhibitor, inhibitor, Target Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 153
Risedronate Approved, Investigational Pharma Inhibition, Inhibitor, inhibitor, Target 0
Pamidronate Approved Pharma inhibitor, Target 42
Ibandronate Approved, Investigational Pharma inhibitor, Target 0

(9) Additional Compounds for FDPS Gene - From: NovoSeek, IUPHAR, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NE97221
Inhibition, Inhibitor
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
3-hydroxy-3-methylglutaryl-coa
  • (S)-3-hydroxy-3-methylglutaryl-CoA
  • (S)-3-hydroxy-3-methylglutaryl-Coenzyme A
  • 3-Hydroxy-3-methyl-Glutaryl-CoA
  • 3-Hydroxy-3-methyl-Glutaryl-Coenzyme A
  • 3-Hydroxy-3-methylglutaryl-CoA
1553-55-5
aspartate
Fatty acid
genes like me logo Genes that share compounds with FDPS: view

Transcripts for FDPS Gene

Unigene Clusters for FDPS Gene

Farnesyl diphosphate synthase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDPS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDPS Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - -
SP10: - - -
SP11: - - - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - -
SP20: - - - - - -
SP21: - - - - - - -
SP22: - - - - - - - - - - - -
SP23: -

ExUns: 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for FDPS Gene

GeneLoc Exon Structure for
FDPS
ECgene alternative splicing isoforms for
FDPS

Expression for FDPS Gene

mRNA expression in normal human tissues for FDPS Gene

Protein differential expression in normal tissues from HIPED for FDPS Gene

This gene is overexpressed in Fetal testis (11.2) and Adrenal (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FDPS Gene



SOURCE GeneReport for Unigene cluster for FDPS Gene Hs.335918

genes like me logo Genes that share expression patterns with FDPS: view

Protein tissue co-expression partners for FDPS Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FDPS Gene

Orthologs for FDPS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FDPS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FDPS 35
  • 87.91 (n)
  • 88.67 (a)
-- 36
  • 85 (a)
OneToMany
FDPS 36
  • 37 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FDPS 35
  • 87.03 (n)
  • 87.35 (a)
FDPS 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fdps 35
  • 85.6 (n)
  • 83.77 (a)
Fdps 16
Fdps 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FDPS 35
  • 99.76 (n)
  • 100 (a)
FDPS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fdps 35
  • 84.51 (n)
  • 85.27 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves FDPS 35
  • 71.72 (n)
  • 69.7 (a)
FDPS 36
  • 6 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FDPS 36
  • 26 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fdps 35
  • 71.04 (n)
  • 68.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25257 35
zebrafish
(Danio rerio)
Actinopterygii fdps 35
  • 62.49 (n)
  • 63.25 (a)
fdps 36
  • 8 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fpps 37
  • 46 (a)
Fpps 35
  • 54.47 (n)
  • 46.9 (a)
Fpps 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007104 35
  • 54.13 (n)
  • 44.48 (a)
worm
(Caenorhabditis elegans)
Secernentea R06C1.2 37
  • 35 (a)
fdps-1 36
  • 32 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL122W 35
  • 56.51 (n)
  • 50 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A06732g 35
  • 51.75 (n)
  • 46.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG20 35
  • 52.66 (n)
  • 46.45 (a)
ERG20 36
  • 44 (a)
OneToOne
ERG20 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FPS2 35
  • 52.82 (n)
  • 48.07 (a)
rice
(Oryza sativa)
Liliopsida Os05g0543400 35
  • 52.89 (n)
  • 47.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01175 35
  • 58.63 (n)
  • 52.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fps1 35
  • 52.99 (n)
  • 52.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for FDPS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FDPS Gene

ENSEMBL:
Gene Tree for FDPS (if available)
TreeFam:
Gene Tree for FDPS (if available)

Paralogs for FDPS Gene

genes like me logo Genes that share paralogs with FDPS: view

No data available for Paralogs for FDPS Gene

Variants for FDPS Gene

Sequence variations from dbSNP and Humsavar for FDPS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2148136 -- 155,312,273(+) ATGCC(A/G)TTGGA reference, missense, utr-variant-5-prime
rs10458626 -- 155,311,898(+) AACCC(A/G)GAGAC intron-variant
rs11264359 -- 155,313,038(+) GCAGA(A/G)ATTGA intron-variant
rs11556432 -- 155,312,319(+) ATTCC(A/G/T)GGAGC missense, reference, utr-variant-5-prime
rs11556437 -- 155,312,333(+) TGGAG(C/T)CAAGG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FDPS Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv872457 CNV Loss 21882294
nsv831636 CNV Loss 17160897
esv33869 CNV Loss 17666407
nsv3032 CNV Insertion 18451855

Variation tolerance for FDPS Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDPS Gene

HapMap Linkage Disequilibrium report
FDPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDPS Gene

Disorders for FDPS Gene

MalaCards: The human disease database

(3) MalaCards diseases for FDPS Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
osteonecrosis of the jaw
prothrombin deficiency
  • hypoprothrombinemia
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
- elite association
Search FDPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for FDPS

Genetic Association Database (GAD)
FDPS
Human Genome Epidemiology (HuGE) Navigator
FDPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FDPS
genes like me logo Genes that share disorders with FDPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FDPS Gene

Publications for FDPS Gene

  1. Drug insight: Bisphosphonates for postmenopausal osteoporosis. (PMID: 16932286) Chapurlat R.D. … Delmas P.D. (Nat Clin Pract Endocrinol Metab 2006) 23 25 26 67
  2. Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy. (PMID: 15487700) Zhang P.L. … Brown R.E. (Ann. Clin. Lab. Sci. 2004) 23 25 26 67
  3. Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. (PMID: 15713990) Notarnicola M. … Caruso M.G. (Oncology 2004) 23 25 26 67
  4. The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. (PMID: 12177810) Riebeling C. … Geilen C.C. (Br. J. Cancer 2002) 23 25 26 67
  5. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. (PMID: 11160603) Dunford J.E. … Rogers M.J. (J. Pharmacol. Exp. Ther. 2001) 23 25 26 67

Products for FDPS Gene

Sources for FDPS Gene

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