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FDPS Gene

protein-coding GIFtS: 66

GC01P153545

farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FPPS ^²
FPS ^², ³, ⁵
KIAA1293 ^³
OTTHUMP00000015807 ^²
OTTHUMP00000015808 ^²
dimethylallyltranstransferase ^²
geranyltranstransferase ^²

Descriptions
FPP synthetase ^², ³
Farnesyl diphosphate synthetase ^³
farnesyl diphosphate synthase ^²
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) ^²
farnesyl pyrophosphate synthetase ^²

External Ids
HGNC: 3631¹
Entrez Gene: 2224²
UniProtKB: P14324³
Ensembl: ENSG00000160752⁷

Search outside databases for aliases for FDPS gene

Previous GC identifers: GC01P153136 GC01P151019 GC01P152056 GC01P152495 GC01P152091

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FDPS:

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl

pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting

product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a

substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain

hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the

post-translational modifications of small GTPases and have been used to treat diseases related to

bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X.

Multiple transcript variants encoding different isoforms have been found for this gene.

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl

diphosphate (FPP), a precursor for several classes of essential metabolites including sterols,

dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation

and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with

the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant

geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FDPS gene

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22

FDPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P153545: (about GC identifiers)

Start:	153,545,331 bp from pter
End:	153,557,080 bp from pter
Size:	11,750 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324 (See protein sequence)

Recommended Name: Farnesyl pyrophosphate synthetase

Size: 419 amino acids; 48275 Da

Subunit: Homodimer. Interacts with RSAD2. Interacts with HTLV-1 protein p13(II)

Subcellular location: Cytoplasm

Caution: It is uncertain whether Met-1 or Met-67 is the initiator

PDB structures from and Proteopedia :

1YQ7 (3D)

1YV5 (3D)

1ZW5 (3D)

2F7M (3D)

2F89 (3D)

2F8C (3D)

2F8Z (3D)

2F92 (3D)

2F94 (3D)

2F9K (3D)

2OPM (3D)

2OPN (3D)

2QIS (3D)

2RAH (3D)

2VF6 (3D)

3B7L (3D)

3CP6 (3D)

Secondary accessions: Q96G29

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001129293.1 NP_001129294.1 NP_001995.1

ENSEMBL proteins:

ENSP00000357340 ENSP00000349078

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FDPS)
	Human Recombinant Proteins from Abnova (FDPS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for FDPS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FDPS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FDPS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FDPS)
	Novus Biologicals Antibody for FDPS

Assays for FDPS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14324

ProtoNet protein and cluster: P14324

1 Blocks protein family: IPB000092 Polyprenyl synthetase

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Similarity: Belongs to the FPP/GGPP synthetase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FDPS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002004

Applied Biosystems Silencer® siRNAs for FDPS

Sigma-Aldrich siRNA and siRNA Panels for FDPS

Sigma-Aldrich shRNA for FDPS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FDPS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135821
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135821
untagged cDNA clones in CMV expression vector (see all 4): AK022841

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001135821

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl

diphosphate (FPP), a precursor for several classes of essential metabolites including sterols,

dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation

and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with

the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant

geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

Catalytic activity: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl

diphosphate

Catalytic activity: Geranyl diphosphate + isopentenyl diphosphate = diphosphate +

trans,trans-farnesyl diphosphate

Enzyme regulation: Inactivated by interferon-induced RSAD2. This inactivation may result of

disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many

envelopped viruses need lipid rafts to bud efficiently out of the cell

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004161	dimethylallyltranstransferase activity	IEA	--
GO:0004337	geranyltranstransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for FDPS (Your Favorite Gene powered by Ingenuity)

Biosynthesis of Steroids

GeneDecks FDPS for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: FPPS_HUMAN, P14324

Pathway: Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and

isopentenyl-PP: step 1/1

Pathway: Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and

isopentenyl-PP: step 1/1

5/16 Interacting proteins for FDPS (ENSP00000357340³ P14324²) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²	MINT-2858967
FDFT1	ENSP00000220584³	STRING (score=.97)
IDI1	ENSP00000370748³	STRING (score=.958)
MVD	ENSP00000301012³	STRING (score=.947)
GGPS1	ENSP00000282841³	STRING (score=.944)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006695	cholesterol biosynthetic process	TAS	2690933
GO:0008299	isoprenoid biosynthetic process	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for FDPS available from Tocris Bioscience

Compound	Action	CAS number
Risedronate	Farnesyl diphosphate (FPP) synthase inhibitor	[105462-24-6]

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10 Novoseek chemical compound relationships for FDPS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
farnesyl diphosphate	97.47	130	11785983 (5), 10620343 (5), 11160603 (5), 1429508 (3) (see all 72)
isopentenyl diphosphate	86.86	8	11785983 (2), 11112517 (1), 10620343 (1), 8262934 (1) (see all 6)
mevalonate	79.46	12	11785983 (2), 16179378 (2), 11577991 (1), 16932286 (1) (see all 9)
squalene	72.39	4	11792726 (1), 8619637 (1), 11773414 (1), 9508001 (1)
sterol	69.15	7	9430668 (1), 15473864 (1), 8864955 (1), 10620343 (1) (see all 5)
3-hydroxy-3-methylglutaryl-coa	53.10	2	12754279 (1), 15967538 (1)
cholesterol	49.34	19	11577991 (1), 8086404 (1), 9430668 (1), 10946023 (1) (see all 14)
fatty acid	29.50	3	12754279 (1), 9508001 (1)
lipid	0.00	1	18175373 (1)
calcium	0.00	1	1346397 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FDPS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002004

Sigma-Aldrich siRNA and siRNA Panels for FDPS

Sigma-Aldrich shRNA for FDPS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135821 NM_001135822 NM_002004

REFSEQ mRNAs for FDPS gene (3 alternative transcripts):

NM_001135821.1 NM_001135822.1 NM_002004.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135821 NM_001135822 NM_002004

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135821
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135821
                                 untagged cDNA clones in CMV expression vector (see all 4): AK022841

Additional cDNA sequence:

AK291084.1 BC010004.2 CR590457.1 CR596980.1 CR598280.1 CR599124.1 CR625993.1 D14697.1

J05262.1 M29863.1

24/60 DOTS entries (see all 60 ):

DT.100712134 DT.40235399 DT.85104788 DT.100639599 DT.95133952 DT.92468004 DT.100701015 DT.92467985

DT.92468021 DT.92467976 DT.100701014 DT.92468010 DT.100800090 DT.101985274 DT.95302259 DT.97862674

DT.121365043 DT.121365136 DT.100700983 DT.95144374 DT.121365069 DT.121365163 DT.100039672 DT.95146655

24/785 AceView cDNA sequences (see all 785 ):

CA428103 BQ055194 CB138402 BG697158 BE746682 BI092666 BQ642474 BQ053766

AL546559 BU845295 BG577339 AU076552 BU856435 BU844835 BQ643366 BQ058201

BE266727 BM449563 BQ062373 BU151518 AI304609 BG677725 BQ877451 BQ054349

highest scoring ESTs for FDPS:

D14697 AA078786 AA493524 AA507460 AA527362 AA634724 AA809315 AA877772 AA903007 AI066793

Unigene Cluster for FDPS:

Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)

Hs.335918 [show with all ESTs]

Unigene Representative Sequence: BM542682

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for FDPS (see all 23 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·
SP1:																	-		-		-		-		-		-		-						-				-		-		-
SP2:																	-		-		-		-		-		-								-				-		-		-
SP3:																	-		-		-		-		-		-		-		-		-		-				-		-		-
SP4:																	-		-		-		-												-				-		-		-
SP5:																							-		-		-								-				-		-		-

ExUns:	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b
SP1:							-
SP2:							-
SP3:							-
SP4:							-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for FDPS

2 Ensembl transcripts including schematic representations:

ENST00000368356 ENST00000356657

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FDPS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FDPS

¹ / ² / ³

3 probe-sets matching FDPS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37325_at²^{, 3}	U95-A	8	1.00	0.67	1.00	1.00	D14697	1.00	1.00	1.00	1
201275_at²^{, 3}	U133-A	7	1.00	0.77	--	--	NM_002004	0.60	1.00	0.82	1
201275_at²	U133Plus2	7	1.00	0.77	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAGGAATTG

SOURCE GeneReport for Unigene cluster: Hs.335918
Expression variation in blood from EXPOLDB for FDPS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FDPS gene from 5/22 species (see all 22 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FDPS¹	--	farnesyl diphosphate synthase (farnesyl pyrophosphate more	87.03(n) 87.35(a)	480129 XM_537252.2 XP_537252.2
chimpanzee (Pan troglodytes)	FDPS¹	--	farnesyl diphosphate synthase (farnesyl pyrophosphate more	99.76(n) 100(a)	457366 XM_001160109.1 XP_001160109.1
cow (Bos taurus)	FDPS¹	--	farnesyl diphosphate synthase (farnesyl pyrophosphate more	87.91(n) 88.67(a)	281156 NM_177497.2 NP_803463.1
rat (Rattus norvegicus)	Fdps¹	--	farnesyl diphosphate synthase (farnesyl pyrophosphate more	84.51(n) 85.27(a)	83791 NM_031840.1 NP_114028.1
mouse (Mus musculus)	Fdps^{1, 5}	3 (42.60 cM)⁵	farnesyl diphosphate synthetase^{1, 5}	85.08(n)¹ 84.42(a)¹	110196¹ NM_134469.3¹ NP_608219.1¹ AF309508⁵ AI256750⁵ (see all 18)

About this table Species with no ortholog for FDPS

ENSEMBL Gene Tree for FDPS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/65 NCBI SNPs in FDPS are shown (see all 65 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6672284^1,2	A,C	153544587(+)	`tctccC/Tgcctc`	1	--	ng5¹		0	--	--	--	--
	rs12033064^1,2	H	153544085(+)	`ccttgT/Cttagc`	1	--	ng5¹		4		EU EA WA	414
	rs12043597^1,2	H	153545065(+)	`CGGCAC/TTGACG`	1	--	ng5¹ tfbs³		4		EU EA WA	420
--	rs2148136^1,2	H	153548688(+)	`ATGCCA/GTTGGA`	3	I/V	mis¹ ese³		4		EU EA WA	406
--	rs11556432^1,2	H	153548734(+)	`ATTCCG/TGGAGC`	3	R/L	mis¹		4		EU EA WA	406
	rs11264359^1,2	A,C,F,H	153549453(+)	`GCAGAG/AATTGA`	1	--	int¹		8		EU EA WA	832
	rs2297480^1,2	A,C,F,H	153546106(-)	`ACCCCC/AGCCTT`	1	--	int¹		9		EA EU WA NA	2250
	rs11264360^1,2	A,C,H	153551210(+)	`TTTTTT/AAATTT`	1	--	int¹ trp³		2		EU WA	238
	rs17367421^1,2	F,H	153553865(+)	`TCTGAG/CCCAAA`	1	--	int¹		7		NA EU EA WA	562
--	rs10796941^1,2	A,C	153550885(+)	`CACCAC/TGCCTG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FDPS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134629

7 Novoseek disease relationships for FDPS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
monocytic leukemia	53.15	1	1968462 (1)
osteoporosis	47.73	1	17905588 (1)
bone diseases	33.36	1	17905588 (1)
response acute phase	28.10	2	17062705 (1), 16650801 (1)
cancer	2.20	2	14680449 (1)
tumors	0.00	2	15459425 (1), 18454049 (1)
metastasis	0.00	1	14680449 (1)

About this table

Human Genome Epidemiology Navigator: FDPS (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/90 PubMed articles for FDPS gene (see all 90 ):

Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3- hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester. (PubMed id 1968462)^{1, 2, 3, 4} Wilkin D.J.... Edwards P.A. (1990)
Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. (PubMed id 11773414)^{1, 3, 4} Lefebvre L.... Willems L. (2002)
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. (PubMed id 16684881)^{3, 4} Kavanagh K.L.... Oppermann U. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{3, 4} Nomura N....Tabata S. (1994)
Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells. (PubMed id 2690933)^{3, 4} Sheares B.T.... Karkas J.D. (1989)
Mitochondrial targeting of farnesyl diphosphate synthase is a widespread phenomenon in eukaryotes. (PubMed id 17198737)^{1, 3} Martin D....Belles X. (2007)
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. (PubMed id 11160603)^{1, 3} Dunford J.E....Rogers M.J. (2001)
Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. (PubMed id 11785983)^{1, 3} Thompson K....Rogers M.J. (2002)
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. (PubMed id 10620343)^{1, 3} Bergstrom J.D....Rodan G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2224	HGNC: 3631	AceView: FDPS	Ensembl:ENSG00000160752	euGenes: HUgn2224
ECgene: FDPS	H-InvDB: FDPS

(According to HUGE)
About This Section

HUGE: KIAA1293

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FDPS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FDPS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FDPS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FDPS		Antibodies for FDPS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FDPS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FDPS)
	Antibodies (FDPS)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FDPS)
	Antibodies (FDPS)

Search OriGene for FDPS

Tocris compounds for FDPS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FDPS

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FDPS Gene at Home site.
Version 2.41.1
server5.xennexinc.com

FDPS Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for FDPS

Summaries
for FDPS

Genomic Location
for FDPS

Proteins
for FDPS

Protein Domains/
Families
for FDPS

Gene Function
for FDPS

Pathways & Interactions
for FDPS

Drugs & Compounds
for FDPS

Transcripts
for FDPS

Expression
for FDPS

Orthologs
for FDPS

Paralogs
for FDPS

SNPs/Variants
for FDPS

Disorders & Mutations
for FDPS

Medical News
for FDPS

Publications
for FDPS

Search for FDPS

Genome Databases showing FDPS

Other Databases showing FDPS

Specialized Databases showing FDPS

Licensable Technologies
for FDPS

Services
for FDPS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FDPS Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor FDPS

Summariesfor FDPS

Genomic Locationfor FDPS

Proteinsfor FDPS

Protein Domains/Familiesfor FDPS

Gene Functionfor FDPS

Pathways & Interactionsfor FDPS

Drugs & Compoundsfor FDPS

Transcriptsfor FDPS

Expression for FDPS

Orthologsfor FDPS

Paralogsfor FDPS

SNPs/Variantsfor FDPS

Disorders & Mutationsfor FDPS

Medical Newsfor FDPS

Publicationsfor FDPS

Search for FDPS

Genome Databases showing FDPS

Other Databases showing FDPS

Specialized Databases showing FDPS

Licensable Technologiesfor FDPS

Servicesfor FDPS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FDPS

Summaries
for FDPS

Genomic Location
for FDPS

Proteins
for FDPS

Protein Domains/
Families
for FDPS

Gene Function
for FDPS

Pathways & Interactions
for FDPS

Drugs & Compounds
for FDPS

Transcripts
for FDPS

Expression
for FDPS

Orthologs
for FDPS

Paralogs
for FDPS

SNPs/Variants
for FDPS

Disorders & Mutations
for FDPS

Medical News
for FDPS

Publications
for FDPS

Licensable Technologies
for FDPS

Services
for FDPS